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https://www.readbyqxmd.com/read/28334353/suppression-of-v1-feedback-produces-a-shift-in-the-topographic-representation-of-receptive-fields-of-lgn-cells-by-unmasking-latent-retinal-drives
#1
Jordi Aguila, F Javier Cudeiro, Casto Rivadulla
In awake monkeys, we used repetitive transcranial magnetic stimulation (rTMS) to focally inactivate visual cortex while measuring the responsiveness of parvocellular lateral geniculate nucleus (LGN) neurons. Effects were noted in 64/75 neurons, and could be divided into 2 main groups: (1) for 39 neurons, visual responsiveness decreased and visual latency increased without apparent shift in receptive field (RF) position and (2) a second group (n = 25, 33% of the recorded cells) whose excitability was not compromised, but whose RF position shifted an average of 4...
March 18, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28331874/the-importance-of-constructive-feedback-implications-of-top-down-regulation-in-the-development-of-neural-circuits
#2
Andrew D Thompson, Chinfei Chen
Neural circuits in sensory pathways develop through a general strategy of overproduction of synapses followed by activity-driven pruning to fine-tune connectivity for optimal function. The early visual pathway, consisting of the retina → visual thalamus → primary visual cortex, has served for decades as a powerful model system for probing the mechanisms and logic of this process. In addition to these feedforward projections, the early visual pathway also includes a substantial feedback component in the form of corticothalamic projections from the deepest layer of primary visual cortex...
2017: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/28327348/know-thy-agency-in-predictive-coding-meta-monitoring-over-forward-modeling
#3
Tomohisa Asai
Though the computation of agency is thought to be based on prediction error, it is important for us to grasp our own reliability of that detected error. Here, the current study shows that we have a meta-monitoring ability over our own forward model, where the accuracy of motor prediction and therefore of the felt agency are implicitly evaluated. Healthy participants (N=105) conducted a simple motor control task and SELF or OTHER visual feedback was given. The relationship between the accuracy and confidence in a mismatch detection task and in a self-other attribution task was examined...
March 16, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28326432/harnessing-scientific-literature-reports-for-pharmacovigilance-prototype-software-analytical-tool-development-and-usability-testing
#4
Alfred Sorbello, Anna Ripple, Joseph Tonning, Monica Munoz, Rashedul Hasan, Thomas Ly, Henry Francis, Olivier Bodenreider
OBJECTIVES: We seek to develop a prototype software analytical tool to augment FDA regulatory reviewers' capacity to harness scientific literature reports in PubMed/MEDLINE for pharmacovigilance and adverse drug event (ADE) safety signal detection. We also aim to gather feedback through usability testing to assess design, performance, and user satisfaction with the tool. METHODS: A prototype, open source, web-based, software analytical tool generated statistical disproportionality data mining signal scores and dynamic visual analytics for ADE safety signal detection and management...
March 22, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28324753/error-augmentation-feedback-for-lateral-weight-shifting
#5
Kevin O'Brien, Charles R Crowell, James Schmiedeler
This study examines the effect of error augmentation of center of pressure (CoP) visual feedback on the performance of a lateral weight shifting task. Error augmentation emphasizes deviations from a standard CoP trajectory generated from existing data of over 2000 weight shifts collected with young, healthy subjects. Thirty-six subjects completed nine lateral weight shifting sessions, of which four were training sessions between each of the five testing sessions. Half of the subjects received error augmentation feedback during the training sessions, while the other half received the unaltered, control feedback...
March 6, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28323444/evaluating-driver-drowsiness-countermeasures
#6
John G Gaspar, Timothy L Brown, Chris W Schwarz, John D Lee, Julie Kang, James S Higgins
Objective Driver drowsiness contributes to a substantial number of fatal and non-fatal crashes, with recent estimates attributing up to 21% of fatal crashes to drowsiness. This paper describes recent NHTSA research on in-vehicle drowsiness countermeasures. Recent advances in technology and state detection algorithms have shown success in detecting drowsiness using a variety of data sources, including camera-based eye tracking, steering wheel position, yaw rate, and vehicle lane position. However, detection is just the first step in reducing drowsy driving crashes...
March 21, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28322127/video-assisted-septoplasty
#7
Akram Rahal, Marie-Pierre Charron
Teaching and learning septoplasty is challenging due to the limited and intermittent visualization of the surgical site by the resident and the mentor. Our objective was to develop and test the surgical tools required to achieve optimal visualization of the surgical field during septal surgery without having to modify the way conventional septoplasty is performed. A flexible high-definition endoscope is mounted on a modified 50-mm nasal speculum. This allows real-time visualization of all steps of the surgery on the video monitor...
February 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28320425/patient-compliance-with-touchdown-weight-bearing-after-microfracture-treatment-of-talar-osteochondral-lesions
#8
Gökhan Polat, Gökhan Karademir, Ekin Akalan, Mehmet Aşık, Mehmet Erdil
BACKGROUND: The aim of this study was to prospectively evaluate the compliance of our patients with a touchdown weight bearing (without supporting any weight on the affected side by only touching the plantar aspect of the foot to the ground to maintain balance to protect the affected side from mechanical loading) postoperative rehabilitation protocol after treatment of talar osteochondral lesion (TOL). METHODS: Fourteen patients, who had been treated with arthroscopic debridement and microfracture, were followed prospectively...
March 20, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28319608/cerebellar-granule-cells-acquire-a-widespread-predictive-feedback-signal-during-motor-learning
#9
Andrea Giovannucci, Aleksandra Badura, Ben Deverett, Farzaneh Najafi, Talmo D Pereira, Zhenyu Gao, Ilker Ozden, Alexander D Kloth, Eftychios Pnevmatikakis, Liam Paninski, Chris I De Zeeuw, Javier F Medina, Samuel S-H Wang
Cerebellar granule cells, which constitute half the brain's neurons, supply Purkinje cells with contextual information necessary for motor learning, but how they encode this information is unknown. Here we show, using two-photon microscopy to track neural activity over multiple days of cerebellum-dependent eyeblink conditioning in mice, that granule cell populations acquire a dense representation of the anticipatory eyelid movement. Initially, granule cells responded to neutral visual and somatosensory stimuli as well as periorbital airpuffs used for training...
March 20, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28315946/changing-the-size-of-a-mirror-reflected-hand-moderates-the-experience-of-embodiment-but-not-proprioceptive-drift-a-repeated-measures-study-on-healthy-human-participants
#10
Priscilla G Wittkopf, Donna M Lloyd, Mark I Johnson
Mirror visual feedback is used for reducing pain and visually distorting the size of the reflection may improve efficacy. The findings of studies investigating size distortion are inconsistent. The influence of the size of the reflected hand on embodiment of the mirror reflection is not known. The aim of this study was to compare the effect of magnifying and minifying mirror reflections of the hand on embodiment measured using an eight-item questionnaire and on proprioceptive drift. During the experiment, participants (n = 45) placed their right hand behind a mirror and their left hand in front of a mirror...
March 18, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28314817/fef-controlled-alpha-delay-activity-precedes-stimulus-induced-gamma-band-activity-in-visual-cortex
#11
Tzvetan Popov, Sabine Kastner, Ole Jensen
Recent findings in the visual system of non-human primates have demonstrated an important role of gamma band activity (40 - 100 Hz) in the feed-forward flow of sensory information, whereas feedback control appears to be dynamically established by oscillations in the alpha (8 - 13 Hz) and beta bands (13 - 18 Hz) (van Kerkoerle et al., 2014; Bastos et al., 2015). It is not clear, however, how alpha oscillations are controlled and how they interact with the flow of visual information mediated by gamma band activity...
March 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28314520/interaction-between-postural-asymmetry-and-visual-feedback-effects-in-undisturbed-upright-stance-control-in-healthy-adults
#12
Patrice R Rougier, Samir Boudrahem
OBJECTIVES: The technique of additional visual feedback has been shown to significantly decrease the center of pressure (CP) displacements of a standing subject. Body-weight asymmetry is known to increase postural instability due to difficulties in coordinating the reaction forces exerted under each foot and is often a cardinal feature of various neurological and traumatic diseases. To examine the possible interactions between additional visual feedback and body-weight asymmetry effects, healthy adults were recruited in a protocol with and without additional visual feedback, with different levels of body-weight asymmetry...
March 14, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28304373/anticipatory-action-planning-in-blind-and-sighted-individuals
#13
Andrea Cavallo, Caterina Ansuini, Monica Gori, Carla Tinti, Alessia Tonelli, Cristina Becchio
Several studies on visually guided reach-to-grasp movements have documented that how objects are grasped differs depending on the actions one intends to perform subsequently. However, no previous study has examined whether this differential grasping may also occur without visual input. In this study, we used motion capture technology to investigate the influence of visual feedback and prior visual experience on the modulation of kinematics by intention in sighted (in both full-vision and no-vision conditions), early-blind and late-blind participants...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28303262/parallel-specification-of-visuomotor-feedback-gains-during-bimanual-reaching-to-independent-goals
#14
Anouk J de Brouwer, Tayler Jarvis, Jason P Gallivan, J Randall Flanagan
During goal-directed reaching, rapid visuomotor feedback processes enable the human motor system to quickly correct for errors in the trajectory of the hand that arise from motor noise and, in some cases, external perturbations. To date, these visuomotor responses, the gain of which is sensitive to features of the task and environment, have primarily been examined in the context of unimanual reaching movements toward a single target. However, many natural tasks involve moving both hands together, often to separate targets, such that errors can occur in parallel and at different spatial locations...
March 2017: ENeuro
https://www.readbyqxmd.com/read/28303261/long-lasting-visuo-vestibular-mismatch-in-freely-behaving-mice-reduces-the-vestibulo-ocular-reflex-and-leads-to-neural-changes-in-the-direct-vestibular-pathway
#15
Julie Carcaud, Filipa França de Barros, Erwin Idoux, Daniel Eugène, Lionel Reveret, Lee E Moore, Pierre-Paul Vidal, Mathieu Beraneck
Calibration of the vestibulo-ocular reflex (VOR) depends on the presence of visual feedback. However, the cellular mechanisms associated with VOR modifications at the level of the brainstem remain largely unknown. A new protocol was designed to expose freely behaving mice to a visuo-vestibular mismatch during a 2-week period. This protocol induced a 50% reduction of the VOR. In vivo pharmacological experiments demonstrated that the VOR reduction depends on changes located outside the flocculus/paraflocculus complex...
January 2017: ENeuro
https://www.readbyqxmd.com/read/28302678/bright-flash-response-recovery-of-mammalian-rods-in-vivo-is-rate-limited-by-rgs9
#16
Gabriel Peinado Allina, Christopher Fortenbach, Franklin Naarendorp, Owen P Gross, Edward N Pugh, Marie E Burns
The temporal resolution of scotopic vision is thought to be constrained by the signaling kinetics of retinal rods, which use a highly amplified G-protein cascade to transduce absorbed photons into changes in membrane potential. Much is known about the biochemical mechanisms that determine the kinetics of rod responses ex vivo, but the rate-limiting mechanisms in vivo are unknown. Using paired flash electroretinograms with improved signal-to-noise, we have recorded the amplitude and kinetics of rod responses to a wide range of flash strengths from living mice...
March 16, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28300635/motor-output-oscillations-with-magnification-of-visual-feedback-in-older-adults
#17
Seoung Hoon Park, MinHyuk Kwon, Evangelos A Christou
Magnification of task visual feedback increases force variability in older adults. Although the increased force variability with magnified visual feedback in older adults relates to the amplification of oscillations in force below 0.5Hz, the related frequency modulation in muscle activity remains unknown. The purpose of this study, therefore, was to characterize the oscillations in muscle activity that contribute to the amplification of force variability with magnified visual feedback in older adults. Fifteen older adults (76...
March 11, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28298764/postoperative-sore-throat-prevention-in-ambulatory-surgery-a-comparison-between-preoperative-aspirin-and-magnesium-sulfate-gargle-a-prospective-randomized-double-blind-study
#18
Surajit Chattopadhyay, Anjan Das, Sabyasachi Nandy, Sandip RoyBasunia, Tapobrata Mitra, Partha Sarathi Halder, Subinay Chhaule, Subrata Kumar Mandal
BACKGROUND: Postoperative sore throat (POST) frequently hampers the positive feedback of ambulatory surgery in spite of so many measures. This study was carried out to compare the efficacy of preoperative magnesium sulfate and aspirin gargle in preventing POST after ambulatory surgery. MATERIALS AND METHODS: It was a prospective, randomized, and double-blinded study. Fifty-six adult patients of either sex, aged 25-50, of American Society of Anesthesiologists physical status I-II, scheduled for day care surgery, were randomly allocated to Group A ([n = 28] receiving aspirin gargle [325 mg tablet]) and Group M ([n = 28] receiving magnesium sulfate [20 mg/kg] gargle)...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28293760/effects-of-partial-absence-of-visual-feedback-information-on-gait-symmetry
#19
Seung-Jae Kim, Marie Aimee Kayitesi, Amy Chan, Kimberli Graham
The incorporation of real-time visual feedback during gait rehabilitation can improve the efficacy of training. Our prior work demonstrated that the imposed distortion of simple visual feedback information of step lengths entails an unintentional adaptive process in the subjects' spatial gait pattern, thereby suggesting the important role of implicit learning in the context of gait rehabilitation that employs visual feedback. The purpose of this study was to investigate whether the removal of a portion of visual feedback information-after it had initially been provided-had any impact on gait symmetry...
March 14, 2017: Applied Psychophysiology and Biofeedback
https://www.readbyqxmd.com/read/28290066/can-communicating-personalised-disease-risk-promote-healthy-behaviour-change-a-systematic-review-of-systematic-reviews
#20
David P French, Elaine Cameron, Jack S Benton, Christi Deaton, Michelle Harvie
BACKGROUND: The assessment and communication of disease risk that is personalised to the individual is widespread in healthcare contexts. Despite several systematic reviews of RCTs, it is unclear under what circumstances that personalised risk estimates promotes change in four key health-related behaviours: smoking, physical activity, diet and alcohol consumption. PURPOSE: The present research aims to systematically identify, evaluate and synthesise the findings of existing systematic reviews...
March 13, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
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