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Gallstones Disease

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https://www.readbyqxmd.com/read/27905020/laparoscopic-versus-open-cholecystectomy-a-cost-effectiveness-analysis-at-rwanda-military-hospital
#1
Allison Silverstein, Ainhoa Costas-Chavarri, Mussa R Gakwaya, Joseph Lule, Swagoto Mukhopadhyay, John G Meara, Mark G Shrime
BACKGROUND: Laparoscopic cholecystectomy is first-line treatment for uncomplicated gallstone disease in high-income countries due to benefits such as shorter hospital stays, reduced morbidity, more rapid return to work, and lower mortality as well-being considered cost-effective. However, there persists a lack of uptake in low- and middle-income countries. Thus, there is a need to evaluate laparoscopic cholecystectomy in comparison with an open approach in these settings. METHODS: A cost-effectiveness analysis was performed to evaluate laparoscopic and open cholecystectomies at Rwanda Military Hospital (RMH), a tertiary care referral hospital in Rwanda...
November 30, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27904310/laparoscopic-cholecystectomy-in-patients-with-history-of-gastrectomy
#2
Ming-Jie Zhang, Qiang Yan, Guo-Lei Zhang, Si-Yu Zhou, Wen-Bin Yuan, Hua-Ping Shen
BACKGROUND AND OBJECTIVES: Patients with previous gastrectomy have an increased incidence of gallstones and gallbladder morbidity requiring surgery. We investigated the possible risk factors that contribute to severe gallbladder disease in patients with previous gastrectomy and the role of laparoscopic cholecystectomy (LC) in the treatment of these patients. METHODS: In this retrospective study, we reviewed a database of patients who underwent LC in our hospital during the period January 1, 2010, through May 1, 2015...
October 2016: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/27896385/pictorial-review-the-pearls-and-pitfalls-of-the-radiological-manifestations-of-gallstone-ileus
#3
REVIEW
Phei Shan Chuah, John Curtis, Nikhil Misra, Dina Hikmat, Sumita Chawla
We present a pictorial review of a range of typical and atypical cases of gallstone ileus (GI), across a wide range of imaging modalities. GI is a complication of gallstone disease causing mechanical intestinal obstruction due to impaction of gallstone in the gastrointestinal tract. The spectrum of presentation can vary enormously, and we highlight the importance of accurate imaging diagnosis of GI especially early use of computed tomography. This will lead to timely and appropriate surgical intervention with the potential avoidance of unnecessary outcomes...
November 28, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27893641/routine-surveillance-cholangiography-following-percutaneous-cholecystostomy-delays-drain-removal-and-cholecystectomy
#4
Tyler J Loftus, Scott C Brakenridge, Frederick A Moore, Camille G Dessaigne, George A Sarosi, William J Zingarelli, Janeen R Jordan, Chasen A Croft, R Stephen Smith, Philip A Efron, Alicia M Mohr
INTRODUCTION: Percutaneous cholecystostomy (PC) is often performed for patients with acute cholecystitis who are at high risk for operative morbidity and mortality. However, the necessity for routine cholangiography following PC remains unclear. We hypothesized that routine surveillance cholangiography (RSC) following PC would provide no benefit compared to on-demand cholangiography (ODC) triggered by signs or symptoms of biliary pathology. METHODS: We performed a three-year retrospective cohort analysis of patients managed with PC for acute cholecystitis at two tertiary care hospitals...
November 23, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27890867/obesity-related-digestive-diseases-and-their-pathophysiology
#5
REVIEW
Su Youn Nam
Obesity is a growing medical and public health problem worldwide. Many digestive diseases are related to obesity. In this article, the current state of our knowledge of obesity-related digestive diseases, their pathogenesis, and the medical and metabolic consequences of weight reduction are discussed. Obesity-related digestive diseases include gastroesophageal reflux disease, Barrett's esophagus, esophageal cancer, colon polyp and cancer, nonalcoholic fatty liver disease, hepatitis C-related disease, hepatocellular carcinoma, gallstone, cholangiocarcinoma, and pancreatic cancer...
November 29, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27885290/effectiveness-of-spinal-anaesthesia-versus-general-anaesthesia-for-open-cholecystectomy
#6
R B Kuju, Y Dongol, R Verma
BACKGROUND: Cholecystectomy is performed either as an open or a laparascopic route. Despite of a number of peri-operative and post-operative benefits of laparascopic cholecystectomy, the traditional and invasive open cholecystectomy is still in frequent practice for various reasons. Though general anaesthesia is regarded as the gold standard anaesthetic technique, alternatives to it such as spinal anaesthesia, with its advantages, outweighs general anaesthesia. Spinal anaesthesia, therefore, could be a safe and effective anaesthetic procedure over general anaesthesia for open cholecystectomy...
May 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27881673/sortilin-1-modulates-hepatic-cholesterol-lipotoxicity-in-mice-via-functional-interaction-with-liver-carboxylesterase-1
#7
Jibiao Li, Yifeng Wang, David Matye, Hemantkumar Chavan, Partha Krishnamurthy, Feng Li, Tiangang Li
Liver plays a key role in cholesterol metabolism. Impaired hepatic cholesterol homeostasis causes intracellular free cholesterol accumulation and hepatocyte injury. Sortilin 1 (Sort1) is an intracellular lysosomal trafficking receptor that was recently identified by GWAS as a novel regulator of cholesterol metabolism in humans. Here we report that Sort1 deficiency protected against cholesterol accumulation-induced liver injury and inflammation in mice. Using LC-MS/MS based proteomics approach, we identified liver carboxyesterase 1 (CES1) as a novel Sort1 interacting protein...
November 23, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27855456/-gallstones-causes-and-consequences
#8
Katharina C Grotemeyer, Frank Lammert
Gallstones and their complications are one of most frequent gastroenterological diseases leading to hospital admission in Europe. Cholesterol stones are the most common; except of few patients there is a direct link to lifestyle. Obesity, diabetes and insufficient physical activity represent the major risk factors. Abdominal ultrasound is the gold standard for detection of gallstones. ERCP is indicated only in the therapeutic setting. In case of symptomatic gallbladder stones as well as bile duct stones, cholecystectomy is necessary...
November 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27834026/timing-of-cholecystectomy-following-endoscopic-sphincterotomy-a-population-based-study
#9
Brett D Mador, Avery B Nathens, Wei Xiong, O Neely M Panton, S Morad Hameed
BACKGROUND: Choledocholithiasis is commonly treated initially with endoscopic sphincterotomy, followed by cholecystectomy to definitively address the underlying problem of cholelithiasis. While the benefits of early cholecystectomy have been realized in other populations, the preferred timing for this subset of patients is less well established. We performed a large, population-based analysis to determine the frequency, benefits, and practice variance in regard to early cholecystectomy on a provincial level...
November 11, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27832205/gallstones-a-worldwide-multifaceted-disease-and-its-correlations-with-gallbladder-carcinoma
#10
Raj Kumar Sharma, Kanchan Sonkar, Neeraj Sinha, Pradeep Rebala, Ahmad Ebrah Albani, Anu Behari, Duvvuri Nageshwar Reddy, Alvina Farooqui, Vinay Kumar Kapoor
BACKGROUND: Gallstones (GS) associated diseases are among the most recurrent and frequent diseases delineated in India and United Arab Emirates. Several reports suggest that the association of GS with gallbladder cancer (GBC) is very high in Northern part of India; however, its occurrence in UAE and Southern part of India is notably low. Therefore, in the present study, we aimed to perform compositional analysis of GS in three different geographical areas by Solid State Nuclear Magnetic Resonance and Fourier Transformed Infrared spectroscopy...
2016: PloS One
https://www.readbyqxmd.com/read/27830040/incidental-non-benign-gallbladder-histopathology-after-cholecystectomy-in-an-united-kingdom-population-need-for-routine-histological-analysis
#11
Krashna Patel, Khaled Dajani, Satheesh Iype, Nikolaos A Chatzizacharias, Saranya Vickramarajah, Prateush Singh, Susan Davies, Rebecca Brais, Siong S Liau, Simon Harper, Asif Jah, Raaj K Praseedom, Emmanuel L Huguet
AIM: To analyse the range of histopathology detected in the largest published United Kingdom series of cholecystectomy specimens and to evaluate the rational for selective histopathological analysis. METHODS: Incidental gallbladder malignancy is rare in the United Kingdom with recent literature supporting selective histological assessment of gallbladders after routine cholecystectomy. All cholecystectomy gallbladder specimens examined by the histopathology department at our hospital during a five year period between March 2008 and March 2013 were retrospectively analysed...
October 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27822917/phosphorylation-and-subcellular-localization-of-na-h-exchanger-isoform-3-nhe3-are-associated-with-altered-gallbladder-absorptive-function-after-formation-of-cholesterol-gallstones
#12
Yongsheng Chen, Shuodong Wu, Yu Tian, Jing Kong
Na(+)/H(+) exchanger isoform 3 (NHE3) dysfunction is thought to contribute to the altered gallbladder absorption that occurs in cholesterol gallstone disease, but the mechanism is unknown. The current study was undertaken to examine the expression, phosphorylation, and subcellular localization of NHE3 in gallbladder epithelium cells (GBECs) of male C57BL/6 mice on a control or lithogenic diet. Thirty-six 8-week-old male C57BL/6 mice were randomly assigned to receive a high cholesterol diet or a regular diet for 8 weeks...
November 7, 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27820614/nonfasting-mild-to-moderate-hypertriglyceridemia-and-risk-of-acute-pancreatitis
#13
Simon B Pedersen, Anne Langsted, Børge G Nordestgaard
Importance: Severe hypertriglyceridemia is associated with increased risk of acute pancreatitis. However, the threshold above which triglycerides are associated with acute pancreatitis is unclear. Objective: To test the hypothesis that nonfasting mild-to-moderate hypertriglyceridemia (177-885 mg/dL; 2-10 mmol/L) is also associated with acute pancreatitis. Design, Setting, and Participants: This prospective cohort study examines individuals from the Copenhagen General Population Study in 2003 to 2015 and the Copenhagen City Heart Study initiated in 1976 to 1978 with follow-up examinations in 1981 to1983, 1991 to 1994, and in 2001 to 2003...
November 7, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27815564/gallstone-disease-and-mortality-a-cohort-study
#14
Daniel Mønsted Shabanzadeh, Lars Tue Sørensen, Torben Jørgensen
OBJECTIVES: The objective of this cohort study was to determine whether subjects with gallstone disease identified by screening of a general population had increased overall mortality when compared to gallstone-free participants and to explore causes of death. METHODS: The study population (N = 5928) was examined 1982-1992 and included an abdominal ultrasound examination to assess gallstone status, a physical examination, blood samples, and a questionnaire about medical history...
November 4, 2016: International Journal of Public Health
https://www.readbyqxmd.com/read/27812789/serum-plant-sterols-associate-with-gallstone-disease-independent-of-weight-loss-and-non-alcoholic-fatty-liver-disease
#15
Pirjo Käkelä, Ville Männistö, Imre Ilves, Maija Vaittinen, Milla-Maria Tauriainen, Matti Eskelinen, Helena Gylling, Hannu Paajanen, Jussi Pihlajamäki
BACKGROUND: Gallstone disease (GD) has been associated with low serum levels of plant sterols. We evaluated the impact of laparoscopic Roux-en-Y gastric bypass (LRYGB) and non-alcoholic fatty liver disease (NAFLD) on the association of GD with low levels of serum plant sterols. METHODS: Two hundred forty-two consecutive morbidly obese patients were recruited to this prospective study. Histological analysis of liver biopsy to diagnose NAFLD was performed. Bile sample was taken during the LRYGB...
November 3, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27806539/the-prevalence-and-risk-factors-of-gallstone-among-adults-in-karachi-south-pakistan-a-population-based-study
#16
Muhammad Bilal, Abdul Haseeb, Muhammad Saad, Muhammad Ahsan, Madiha Raza, Aafia Ahmed, Waqas Shahnawaz, Bilal Ahmed, Vanita Motiani
INTRODUCTION: The present study was aimed to determine the prevalence and risk factors of GSD among a sample of general population in Karachi, South Pakistan. METHODOLOGY: A multistage random sampling method was employed on 30 clusters, where 60 subjects of age>=25 years were randomly recruited from the study population from June 2013 till March 2015. Finally, data was analyzed and logistic regression models were used to find the correlation between selected variables and gallstone disease...
August 10, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27797031/-gallstone-disease-update-2016
#17
REVIEW
Michael Sackmann
No abstract text is available yet for this article.
November 2016: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/27796881/telocytes-new-players-in-gallstone-disease
#18
Artur Pasternak, Krzysztof Gil, Andrzej Matyja
Cholesterol gallstone disease is highly prevalent in Western countries, particularly in women and some specific ethnic groups. The mechanisms behind the formation of gallstones are not clearly understood, but gallbladder dysmotility seems to be a key factor that triggers the precipitation of cholesterol microcrystals from supersaturated lithogenic bile.Given that newly described interstitial cells, telocytes, are present in the gallbladder and they are located in close vicinity of smooth muscle cell and neural fibers possibly interfering with gallbladder motility or contractility, authors are trying to summarize the current knowledge on the role of telocytes with respect to disturbed gallbladder function in gallstone disease...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27782959/predictive-serum-markers-of-gallstone-disease-gazing-into-a-crystal-ball
#19
Marcin Krawczyk, Piero Portincasa, Frank Lammert
No abstract text is available yet for this article.
October 25, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27782193/lipocalin-2-lcn2-is-a-promising-target-for-cholangiocarcinoma-treatment-and-bile-lcn2-level-is-a-potential-cholangiocarcinoma-diagnostic-marker
#20
Kun-Chun Chiang, Ta-Sen Yeh, Ren-Chin Wu, Jong-Hwei S Pang, Chi-Tung Cheng, Shang-Yu Wang, Horng-Heng Juang, Chun-Nan Yeh
Cholangiocarcinoma (CCA) is a devastating disease due to resistance to traditional chemotherapies and radiotherapies. New therapeutic strategies against CCA are urgently needed. This study investigated the role of lipocalin-2 (LCN2) in human cholangiocarcinoma as a potential therapeutic target and diagnostic marker. So far, the role of LCN2 in cancer is still controversial and studies regarding the role of LCN2 in CCA are limited. LCN2 knockdown inhibited CCA cell growth in vitro and in vivo through induction of cell cycle arrest at G0/G1 phases and decreased metastatic potential due to repression of epithelial-mesenchymal transition (EMT)...
October 26, 2016: Scientific Reports
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