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Gallstones Disease

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https://www.readbyqxmd.com/read/28722105/hepatic-cxcl16-is-increased-in-gallstone-accompanied-with-liver-injury
#1
Saisai Zhang, Wei Zhang, Lihua Shi, Anqi Xie, Yihui Shao, Yanna Ye, Xuebo Pan, Zhuofeng Lin, Xiaokun Li, Yi Zhang
BACKGROUND AND AIMS: The current study aimed to investigate the relationship between circulating Soluble C-X-C chemokine ligand 16 (CXCL16) levels and clinical characteristics of gallstone. METHODS: 93 subjects including 53 subjects with gallstone, 25 subjects with non-alcoholic fatty liver disease (NAFLD) and 40 control subjects were recruited. All gallstone subjects underwent ultrasounds to confirm the gallstone patients. Serum CXCL16 levels and other clinical and biochemical parameters in all subjects were obtained based on standard clinical examination methods...
July 19, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28712690/gallstone-disease-optimal-timing-of-treatment
#2
Philipp-Robert Scherber, Frank Lammert, Matthias Glanemann
No abstract text is available yet for this article.
July 13, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28705411/erratum-to-recurrence-of-gallstone-disease-following-non-surgical-treatment-of-acute-cholecystitis-in-the-elderly-population-medclin-barc-148-12-2017-569-572
#3
Ismael Mora-Guzmán, José Luis Muñoz de Nova, Elena Martín-Pérez
No abstract text is available yet for this article.
August 10, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28695432/gallbladder-polypoid-lesions-what-are-they-and-how-should-they-be-treated-a-single-center-experience-based-on-1446-cholecystectomy-patients
#4
Anan Xu, Yu Zhang, Hai Hu, Gang Zhao, Jinli Cai, Anhua Huang
BACKGROUND AND AIM: Gallbladder polypoid-lesions (GPs) are commonly seen on ultrasonography (USG), but several aspects of this problem are ill-defined. This study aimed to analyze clinic and pathologic characteristics of 1446 USG-detected GPs, identify predictive factors for cholesterol lesions and malignancy, and provide comments and recommendations on specific aspects of GPs. METHODS: We retrospectively analyzed clinic files of 1446 patients who underwent cholecystectomy for USG-detected GPs between 2008 and 2015 in Gallbladder Diseases Center, East Hospital of Tongji University...
July 10, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28669532/intraoperative-cholangiography-during-cholecystectomy-among-hospitalized-medicare-beneficiaries-with-non-neoplastic-biliary-disease
#5
Elizabeth J Lilley, John W Scott, Wei Jiang, Anna Krasnova, Nikhila Raol, Navin Changoor, Ali Salim, Adil H Haider, Joel S Weissman, Eric B Schneider, Zara Cooper
BACKGROUND: Prior studies of Medicare beneficiaries with both neoplastic and non-neoplastic indications for cholecystectomy demonstrated a reduced risk of common bile duct (CBD) injury when intraoperative cholangiography (IOC) was used. We sought to determine the association between IOC and CBD injury during inpatient cholecystectomy for non-neoplastic biliary disease and compare survival among those with or without CBD injury. METHODS: Retrospective study of patients ≥66 who underwent inpatient cholecystectomy (2005-2010) for gallstones, cholecystitis, cholangitis, or gallbladder obstruction...
June 23, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28666456/effect-of-cholecystectomy-on-hepatic-fat-accumulation-and-insulin-resistance-in-non-obese-hispanic-patients-a-pilot-study
#6
Víctor Cortés, Nicolás Quezada, Sergio Uribe, Marco Arrese, Flavio Nervi
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. Experimental studies have shown that cholecystectomy (XGB) increases hepatic fat content in mice and appears associated to NAFLD in large retrospective population-based studies. The aim of this study was to prospectively assess the effects of XGB on hepatic fat content (HFC) and insulin resistance (IR) in non-obese, middle aged Hispanic subjects. METHODS: Twenty-six gallstone patients undergoing elective XGB and 16 control subjects with normal livers and gallbladders at ultrasonography were prospectively followed 24 months for changes in HFC and IR...
June 30, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28660886/gallstone-disease-associated-with-increased-risk-of-arterial-stiffness-in-a-taiwanese-population
#7
J-Y Wang, F-H Lu, Z-J Sun, J-S Wu, Y-C Yang, C-T Lee, C-J Chang
Arterial stiffness has similar risk factors to gallstone disease (GSD). However, there are few studies on the association between arterial stiffness and GSD. The aim of this study was to determine the relationship between arterial stiffness and GSD in a Taiwanese population. We enroled 6211 subjects from a health examination centre after excluding those who received medications for diabetes, hypertension and hyperlipidemia or had a history of cardiovascular disease, cerebrovascular disease, cancer, cholecystectomy or ankle-brachial index of ⩽ 0...
June 29, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28658178/liver-cirrhosis-a-risk-factor-for-gallstone-disease-in-chronic-hepatitis-c-patients-in-china
#8
Xu Li, Zhongfeng Wang, Le Wang, Meng Pan, Pujun Gao
We investigated the possible link between liver cirrhosis and gallstone risk in chronic hepatitis C (CHC) patients in China.To analyze the association between liver cirrhosis and gallstone development, we compared outcomes of 133 Chinese CHC patients with gallstones and an age-, sex-, and hepatitis C virus RNA level-matched control group of 431 CHC patients without gallstones.We found that liver cirrhosis was more prevalent in gallstone patients (40.6%) than in the control group (24.4%). Logistic regression analyses adjusting for demographic features and other gallstone risk factors revealed that liver cirrhosis increased the risk of gallstone development 2-fold (adjusted odds ratio [AOR]: 2...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28655415/molecular-signature-of-active-fibrogenesis-prevails-in-biliary-atresia-after-successful-portoenterostomy
#9
Anna Kerola, Hanna Lampela, Jouko Lohi, Päivi Heikkilä, Annika Mutanen, Hannu Jalanko, Mikko P Pakarinen
BACKGROUND: In biliary atresia mechanisms of progressive liver injury leading to need of liver transplantation after successful portoenterostomy remain unknown. A better understanding is a prerequisite for development of novel therapies to extend native liver survival, and we aimed to unravel molecular characteristics of liver injury after successful portoenterostomy. METHODS: Liver biopsies obtained from 28 biliary atresia children during successful portoenterostomy and at median age 3...
June 24, 2017: Surgery
https://www.readbyqxmd.com/read/28651227/double-cystic-duct-preoperatively-diagnosed-and-successfully-treated-with-laparoscopic-cholecystectomy-a-case-report
#10
Atsushi Fujii, Masatsugu Hiraki, Noriyuki Egawa, Hiroshi Kono, Takao Ide, Junichi Nojiri, Junji Ueda, Hiroyuki Irie, Hirokazu Noshiro
INTRODUCTION: A single gallbladder with a double cystic duct is a very rare finding. In addition, few cases with this rare condition are preoperatively diagnosed. However, the preoperative confirmation or suspicion of this rare condition could facilitate safe laparoscopic cholecystectomy, which is a minimally invasive therapeutic modality for gallbladder disease. We herein present a case of gallstone disease in a patient with a double cystic duct who was preoperatively diagnosed and successfully treated with laparoscopic cholecystectomy...
June 13, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28648518/selective-inhibition-of-bet-proteins-reduces-pancreatic-damage-and-systemic-inflammation-in-bile-acid-and-fatty-acid-ethyl-ester-but-not-caerulein-induced-acute-pancreatitis-in-mice
#11
Wei Huang, Andrea C Haynes, Rajarshi Mukherjee, Li Wen, Diane Latawiec, Alexei V Tepikin, David N Criddle, Rab K Prinjha, Nicholas Smithers, Robert Sutton
OBJECTIVES: To evaluate the therapeutic potential of I-BET-762, an inhibitor of the bromodomain and extra-terminal (BET) protein family, in experimental acute pancreatitis (AP). METHODS: AP was induced in mice by retrograde infusion of taurolithocholic acid sulphate into the biliopancreatic duct (TLCS-AP) or two intraperitoneal (i.p.) injections of ethanol and palmitoleic acid 1 h apart (FAEE-AP) or 12 hourly i.p. injections of caerulein (CER-AP). In all treatment groups, I-BET-762 (30 mg/kg, i...
June 10, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28643979/-acute-pancreatitis-new-aspects-for-the-management
#12
Olivier Windisch, Toni Raffoul, Catrina Hansen, Jean-Louis Frossard, Philippe Morel, Léo Bühler
Acute pancreatitis is a frequent disease, with a simple course in 80 % of the cases but a high morbidity and mortality in its severe form. Biliary origin and alcohol represent 80 % of the etiologies. Except endoscopic removal of gallstone for biliary origin, treatment remains symptomatic and focuses on fluid resuscitation, effective antalgia and adapted management of nutrition. This article focuses on the novelties introduced by the revision of the Classification of Atlanta in 2012 and details current guidelines for the management of the disease...
June 14, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28638830/abdominal-hernias-giant-colon-diverticulum-gist-intestinal-pneumatosis-colon-ischemia-cold-intussusception-gallstone-ileus-and-foreign-bodies-our-experience-and-literature-review-of-incidental-gastrointestinal-mdct-findings
#13
REVIEW
G Di Grezia, G Gatta, R Rella, D Donatello, G Falco, R Grassi, R Grassi
Incidental gastrointestinal findings are commonly detected on MDCT exams performed for various medical indications. This review describes the radiological MDCT spectrum of appearances already present in the past literature and in today's experience of several gastrointestinal acute conditions such as abdominal hernia, giant colon diverticulum, GIST, intestinal pneumatosis, colon ischemia, cold intussusception, gallstone ileus, and foreign bodies which can require medical and surgical intervention or clinical follow-up...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28634841/patient-related-risk-factors-for-postoperative-infection-after-cholecystectomy
#14
Gona Jaafar, Folke Hammarqvist, Lars Enochsson, Gabriel Sandblom
BACKGROUND: The impact of patient-related risk factors on the incidence of postoperative infection after cholecystectomy is relatively unknown. AIM: The aim of this study was to explore potential patient-related risk factors for surgical site infection (SSI) and septicaemia following cholecystectomy. MATERIALS AND METHODS: All cholecystectomies registered in the Swedish national population-based register for Gallstone Surgery and Endoscopic Retrograde Cholangiopancreatography (GallRiks) 2006-2014 were identified...
June 20, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28625681/variation-of-calcium-copper-and-iron-levels-in-serum-bile-and-stone-samples-of-patients-having-different-types-of-gallstone-a-comparative-study
#15
Mustafa Khan, Tasneem Gul Kazi, Hassan Imran Afridi, Sirajuddin, Muhammad Bilal, Asma Akhtar, Sabir Khan, Salma Kadar
BACKGROUND: Epidemiological data among the human population has shown a significantly increased incidence of gallstone (GS) disease worldwide. It was studied that some essential (calcium) and transition elements (iron and copper) in bile play an important role in the development of GS. METHOD: The estimation of calcium, copper and iron were carried out in the serum, gall bladder bile and different types of GS (cholesterol, mixed and pigmented) of 172 patients, age ranged 20-55years...
June 15, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28625150/update-on-the-molecular-mechanisms-underlying-the-effect-of-cholecystokinin-and-cholecystokinin-1-receptor-on-the-formation-of-cholesterol-gallstones
#16
Helen H Wang, Piero Portincasa, David Q-H Wang
Cholecystokinin (CCK) is an important neuro-intestinal peptide hormone produced by the enteroendocrine I-cells in the upper part of small intestine. Protein- and fat-enriched food plays an important role in triggering CCK secretion from the intestine. Carbohydrates stimulate only small amounts of CCK release. The CCK-1 receptor (CCK-1R) is largely localized in the gallbladder, sphincter of Oddi, pancreas, small intestine, gastric mucosa, and pyloric sphincter, where it is responsible for CCK to regulate multiple digestive processes including gallbladder contraction, pancreatic secretion, small intestinal transit, and gastric emptying...
June 19, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28614581/clinical-biochemical-and-genetic-characterization-of-north-american-patients-with-erythropoietic-protoporphyria-and-x-linked-protoporphyria
#17
Manisha Balwani, Hetanshi Naik, Karl E Anderson, D Montgomery Bissell, Joseph Bloomer, Herbert L Bonkovsky, John D Phillips, Jessica R Overbey, Bruce Wang, Ashwani K Singal, Lawrence U Liu, Robert J Desnick
Importance: Autosomal recessive erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) are rare photodermatoses presenting with variable degrees of painful phototoxicity that markedly affects quality of life. The clinical variability, determinants of severity, and genotype/phenotype correlations of these diseases are not well characterized. Objective: To describe the baseline clinical characteristics, genotypes, and determinants of disease severity in a large patient cohort with EPP or XLP...
June 14, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28611560/gallstone-ileus-caused-by-cholecystocolonic-fistula-and-gallstone-impaction-in-the-sigmoid-colon-review-of-the-literature-and-novel-surgical-treatment-with-trephine-loop-colostomy
#18
James W O'Brien, Lucy-Anne Webb, Luke Evans, Chris Speakman, Irshad Shaikh
Gallstone ileus is an uncommon cause of intestinal obstruction and occurs following the formation of a cholecystoenteric fistula, permitting passage of gallstones into the gastrointestinal tract. Impaction of a gallstone in the sigmoid colon is rare and is usually at sites of previous colonic disease. Definitive management can be challenging due to the advanced age and co-morbidity usually seen in this group of patients. We describe a patient successfully managed with on-table endoscopy and, under local anaesthetic, the formation of a left iliac fossa trephine loop colostomy, permitting an enterolithotomy to deliver the stone whilst accommodating for severe pre-existing distal sigmoid diverticular disease...
January 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28604381/miniinvasive-surgical-interventions-in-management-of-cholelithiasis-a-retrospective-study
#19
Mamuka R Gurgenidze, Merab A Kiladze, Zurab A Beriashvili, Teimuraz U Tabucadze, Giorgi A Datuashvili
The aim of the present study is to analyze outcomes after laparoscopic cholecystectomy (LC) and minilaparotomy cholecystectomy (MC) for gallstone disease and determine the algorithm of treatment for different groups of patients according to the age, severity of disease and comorbid conditions. This is a multicenter retrospective review of 2997 patients who underwent LC or MC between January 1, 2002 and December 31, 2008. The patients were categorized into LC (1479) and MC (1518) groups. When preoperative examination data were not reliable, we performed abdominal wall lifting with the retractors to visualise abdominal cavity with laparoscope during minilaparotomy...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28599581/changing-management-of-gallstone-related-disease-in-pregnancy-a-retrospective-cohort-analysis
#20
Jonas Hedström, Johan Nilsson, Roland Andersson, Bodil Andersson
OBJECTIVES: Gallstone-related disease is the second most common non-obstetric cause, following appendicitis, for acute abdomen in pregnancy. This study aimed to investigate treatment strategies, changes over time and outcome. MATERIALS AND METHODS: All consecutive patients with symptomatic gallstone-related disease during pregnancy admitted to Skane University hospital in Lund and Malmö 2001-2015 were analysed retrospectively. Information regarding the patient, pregnancy and fetus/child was recorded...
June 9, 2017: Scandinavian Journal of Gastroenterology
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