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https://www.readbyqxmd.com/read/29778842/curcumin-attenuates-sepsis-induced-acute-organ-dysfunction-by-preventing-inflammation-and-enhancing-the-suppressive-function-of-tregs
#1
Longwang Chen, Yang Lu, Linjun Zhao, Lili Hu, Qiaomeng Qiu, Zhuoling Zhang, Mengfang Li, Guangliang Hong, Bing Wu, Guangju Zhao, Zhongqiu Lu
Sepsis is characterized by the extensive release of cytokines and other mediators. It results in a dysregulated immune response and can lead to organ damage and death. Curcumin has anti-inflammatory properties and immunoregulation functions in various disorders such as sepsis, cancer, rheumatoid arthritis, cardiovascular diseases, lung fibrosis, gallstone formation, and diabetes. This paper investigates the effects of curcumin on immune status and inflammatory response in mice subjected to cecal ligation and puncture (CLP)...
May 17, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29773783/cholesteryl-ester-storage-disease-fatal-outcome-without-causal-therapy-in-a-female-patient-with-the-preventable-sequelae-of-progressive-liver-disease-after-many-years-of-mild-symptoms
#2
Ali Canbay, Meike N Müller, Stathis Philippou, Guido Gerken, Andreas Tromm
BACKGROUND Cholesteryl ester storage disease (CESD), also known as lysosomal acid lipase deficiency (LAL-D), is a rare autosomal-recessive inheritable lysosomal storage disease. Since 2015, a causal treatment with sebelipase alfa, which replaces the missing LAL enzyme, has been approved. We report a fatal course of LAL-D in a female patient. CASE REPORT In 1979, CESD was first diagnosed in a 13-year-old female with marked hepatomegaly. At that time, no specific treatment for CESD was available and the spontaneous course of the disease had to be awaited...
May 18, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29772027/association-between-different-combination-of-measures-for-obesity-and-new-onset-gallstone-disease
#3
Tong Liu, Wanchao Wang, Yannan Ji, Yiming Wang, Xining Liu, Liying Cao, Siqing Liu
BACKGROUND: Body mass index(BMI) is a calculation index of general obesity. Waist circumference(WC) is a measure of body-fat distribution and always used to estimate abdominal obesity. An important trait of general obesity and abdominal obesity is their propensity to coexist. Using one single measure of obesity could not estimate persons at risk for GSD precisely. OBJECTIVES: This study aimed to compare the predictive values of various combination of measures for obesity(BMI, WC, waist to hip ratio) for new-onset GSD...
2018: PloS One
https://www.readbyqxmd.com/read/29770794/ursodeoxycholic-acid-protects-interstitial-cajal-like-cells-in-the-gallbladder-from-undergoing-apoptosis-by-inhibiting-tnf-%C3%AE-expression
#4
Jiang-Fan Wan, Shi-Feng Chu, Xin Zhou, Yue-Ting Li, Wen-Bin He, Feng Tan, Piao Luo, Qi-di Ai, Qi Wang, Nai-Hong Chen
Hypomotility is a common symptom of gallstone disease, which is accompanied by a loss of interstitial Cajal-like cells (ICLCs) in the gallbladder. Ursodeoxycholic acid (UDCA) is widely used in treating gallstone disease, and has shown anti-apoptotic and anti-inflammatory effects apart from its ability to dissolve gallstones. In this study, we investigated the anti-apoptotic and anti-inflammatory effects of UDCA on ICLCs in guinea pigs with gallstones. Guinea pigs were fed a high-cholesterol diet for 8 weeks to induce the formation of gallstones...
May 17, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29764733/genetic-polymorphism-of-sterol-transporters-in-children-with-future-gallstones
#5
Markku J Nissinen, Niina Pitkänen, Piia Simonen, Helena Gylling, Jorma Viikari, Olli Raitakari, Terho Lehtimäki, Markus Juonala, Mikko P Pakarinen
BACKGROUND & AIMS: Gallstone disease is related to hypersecretion of cholesterol in bile, and low serum phytosterol levels. We examined how genetic polymorphisms of sterol transporters affect childhood cholesterol metabolism trait predicting adult gallstone disease. PATIENTS AND METHODS: In retrospective controlled study, we determined D19H polymorphism of ABCG8 gene, genetic variation at Niemann-Pick C1-like 1 (NPC1L1) gene locus (rs41279633, rs17655652, rs2072183, rs217434 and rs2073548), and serum cholesterol, noncholesterol sterols and lipids in children affected by gallstones decades later (n = 66) and controls (n = 126)...
April 26, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29758389/gallbladder-perforation-into-the-greater-omentum-following-sleeve-gastrectomy-a-case-report-study
#6
Suhaib J S Ahmad, Sherif M Hakky, Douglas McWhinnie, Claire J Stocker, Peter Thomas, Sami Ahmad
INTRODUCTION: Obesity is considered a major risk factor for gallstone formation and is important due to its increasing prevalence worldwide. Many studies have reported an increased incidence of gallstone formation following bariatric surgery. This report documents a rare case of a complicated cholecystitis following sleeve gastrectomy and describes our management of the case and the management options for gallbladder disease in bariatric patients. PRESENTATION OF CASE: A 60-year-old male was diagnosed with asymptomatic cholelithiasis at the time of sleeve gastrectomy for obesity treatment...
May 9, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29739280/abdominal-pain-after-roux-en-y-gastric-bypass-for-morbid-obesity
#7
Tom Mala, Ingvild Høgestøl
BACKGROUND AND AIMS: Roux-en-Y gastric bypass is widely used as treatment of morbid obesity. Weight loss, effects on obesity-related co-morbidities and quality of life are well documented post Roux-en-Y gastric bypass. Other outcome measures are less well studied. This review explores aspects of prevalence, diagnostic evaluations, etiology, and treatment of abdominal pain specific to Roux-en-Y gastric bypass. METHODS: The review is based on PubMed searches and clinical experience with Roux-en-Y gastric bypass...
May 1, 2018: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29728459/abcg5-and-abcg8-more-than-a-defense-against-xenosterols
#8
Shailendra B Patel, Gregory Graf, Ryan Temel
The elucidation of the molecular basis of the rare disease Sitosterolemia has revolutionized our mechanistic understanding of how dietary sterols are excreted and how cholesterol is eliminated from the body. Two proteins ABCG5 and ABCG8, encoded by the Sitosterolemia locus, work as obligate dimers to pump sterols out of hepatocytes and enterocytes. ABCG5/ABCG8 are key in regulating whole-body sterol trafficking, by eliminating sterols via the biliary tree, as well as the intestinal tract. Importantly, these transporters keep xenosterols from accumulating in the body...
May 4, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29703854/evaluation-of-plasma-microrna-122-high-mobility-group-box-1-and-keratin-18-concentrations-to-stratify-acute-gallstone-disease-a-pilot-observational-cohort-study-in-an-emergency-general-surgery-unit
#9
Francesca Th'ng, Bastiaan Vliegenthart, Jonathan D Lea, Daniel J Antoine, James W Dear, Damian J Mole
OBJECTIVE: To obtain pilot data to evaluate the discriminatory power of biomarkers microRNA-122 (miR-122), high-mobility group box 1 (HMGB1), full-length keratin-18 (flk-18) and caspase-cleaved keratin-18 (cck-18) in plasma to identify potential biliary complications that may require acute intervention. DESIGN: An observational biomarker cohort pilot study. SETTING: In a Scottish University teaching hospital for 12 months beginning on 3 September 2014...
April 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29696323/routine-pathology-and-postoperative-follow-up-are-not-cost-effective-in-cholecystectomy-for-benign-gallbladder-disease
#10
Pim B Olthof, Madelon J H Metman, Ronald R de Krijger, Joris J Scheepers, Daphne Roos, Jan Willem T Dekker
INTRODUCTION: The incidence of gallstone disease is increasing and represents a strain on healthcare systems worldwide. Following cholecystectomy, gallbladder specimens are generally submitted for histopathologic examination and the diagnostic yield of this strategy remains questionable. This study aimed to evaluate the usefulness of routine pathologic examination of the gallbladder specimens and investigate the results of routine postoperative follow-up visits. METHODS: All cholecystectomies performed between January 2011 and July 2017 at a single center were evaluated...
April 25, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29682244/is-there-a-correlation-between-helicobacter-pylori-and-enterohepatic-helicobacter-species-and-gallstone-cholecystitis
#11
Seyed Masih Fatemi, Abbas Doosti, Dariush Shokri, Sadegh Ghorbani-Dalini, Morteza Molazadeh, Hossein Tavakoli, Mohammad Minakari, Hamid Tavakkoli
BACKGROUND Cholecystitis is a common surgical condition. Recently, several authors have reported that DNA of bile tolerant Helicobacter spp. has been found in the human bile colonizing the biliary tract. The aim of this study was to evaluate the association between the presence of Helicobacter spp. and gallstone cholecystitis. METHODS In this case-control study, gallstones, bile, and gallbladder mucosa were collected from 25 patients without gallstone disease, 24 with acute cholecystitis, and 28 with chronic cholecystitis...
January 2018: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29671893/gallstone-disease-and-increased-risk-of-mortality-two-large-prospective-studies-in-us-men-and-women
#12
Yan Zheng, Min Xu, Yoriko Heianza, Wenjie Ma, Tiange Wang, Dianjianyi Sun, Christine M Albert, Frank B Hu, Kathryn M Rexrode, Jo Ann E Manson, Lu Qi
BACKGROUND AND AIM: Gallstone disease has been related to a higher prevalence and incidence of chronic conditions, such as dyslipidemia, obesity, and cardiovascular disease (CVD). However, limited data are available regarding whether gallstone disease is related to mortality. METHODS: We examined the relationship of a history of gallstone disease and risk of death, using Cox proportional hazards regression analysis, among 86,030 women from the Nurses' Health Study and 43,949 men from the Health Professionals Follow-up Study...
April 19, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29671891/the-association-of-circulating-inflammation-proteins-and-gallstone-disease
#13
Zhiwei Liu, Troy J Kemp, Yu-Tang Gao, Amanda Corbel, Emma E McGee, Bingsheng Wang, Ming-Chang Shen, Asif Rashid, Ann W Hsing, Allan Hildesheim, Ruth M Pfeiffer, Ligia A Pinto, Jill Koshiol
BACKGROUND: Inflammation plays a role in the development of both gallstones and gallbladder cancer; however, few studies have investigated the association of circulating inflammation proteins with risk of gallstones. METHODS: We measured 13 cytokines (including 10 interleukins), that have been associated with cancer in serum samples collected from 150 gallstone patients and 149 population-based controls from Shanghai, China, in 1997-2001. We estimated the associations of each cytokine, categorized into quartiles and coded as a trend, with risk of gallstones using logistic regression models adjusted for potential confounders...
April 19, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29662003/ppar-agonists-and-metabolic-syndrome-an-established-role
#14
REVIEW
Margherita Botta, Matteo Audano, Amirhossein Sahebkar, Cesare R Sirtori, Nico Mitro, Massimiliano Ruscica
Therapeutic approaches to metabolic syndrome (MetS) are numerous and may target lipoproteins, blood pressure or anthropometric indices. Peroxisome proliferator-activated receptors (PPARs) are involved in the metabolic regulation of lipid and lipoprotein levels, i.e., triglycerides (TGs), blood glucose, and abdominal adiposity. PPARs may be classified into the α, β/δ and γ subtypes. The PPAR-α agonists, mainly fibrates (including newer molecules such as pemafibrate) and omega-3 fatty acids, are powerful TG-lowering agents...
April 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29660323/nationwide-trends-in-acute-and-chronic-pancreatitis-among-privately-insured-children-and-non-elderly-adults-in-the-united-states-2007-2014
#15
Zachary M Sellers, Donna MacIsaac, Helen Yu, Melody Dehghan, Ke-You Zhang, Rachel Bensen, Jessie J Wong, Cindy Kin, K T Park
BACKGROUND & AIMS: Epidemiologic analyses of acute and chronic pancreatitis (AP and CP) provide insight into causes and strategies for prevention, and affect allocation of resources to its study and treatment. We sought to determine current and accurate incidences of AP and CP, along with the prevalence of CP, in children and adults in the United States. METHODS: We collected data from the Truven MarketScan Research Databases of commercial inpatient and outpatient insurance claims in the United States from 2007 through 2014 (patients 0-64 years old)...
April 13, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29623887/clinical-and-biological-study-of-the-31-cases-of-gallstones
#16
Tayssir Nasri, Abderraouf Cherif, Youssef Gharbi, Ilhem Hellara, Mohamed Zili, Fadoua Neffati, Mohamed Fadhel Najjar
This study reports the clinical and biological signs, as well as the morphological aspect and the chemical composition of the calculus during the biliary stones. The study population consisted of 31 patients with an average age of 49 years (30 women and one man) with biliary lithiasis and who had cholecystectomy. Hepatic colic and epigastralgia were the most evocative clinical signs. The calculus were pigmentary (n=6), cholesterolic and mostly single (n=18), and mixed (n=6) and one infectious multiple lithiasis...
April 1, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29617471/hypophosphatemic-rickets-case-report
#17
Marta Liliane de Almeida Maia, Ana Lucia Santos Abreu, Paulo Cesar Koch Nogueira, Maria Luiza Dautro Moreira do Val, João Tomas de Abreu Carvalhaes, Maria Cristina de Andrade
OBJECTIVE: Early diagnosis and immediate treatment of hypophosphatemic rickets is of utmost importance as it may prevent subsequent sequelae. This report aims at warning pediatricians to consider the presence of the disease. CASE DESCRIPTION: Description of the metabolic profile, creatinine clearance, nutritional status, weight and body structure of a patient who presented the clinical-laboratorial characteristics of hypophosphatemic rickets and was followed in an outpatient clinic for tubulopathies over the period of 12 months...
March 29, 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29560600/prevalence-of-cardiovascular-dysfunction-and-its-association-with-outcome-in-patients-with-acute-pancreatitis
#18
Raghavendra Prasada, Narendra Dhaka, Ajay Bahl, Thakur Deen Yadav, Rakesh Kochhar
BACKGROUND: Organ failure (OF) is the most important predictor of outcome in severe acute pancreatitis (SAP). Cardiovascular failure (CVSF) occurs in a variable proportion of patients with SAP. We aimed to study myocardial dysfunction in acute pancreatitis (AP) and its impact on the outcome. METHODS: In this prospective study between January 2011 and July 2012, consecutive eligible patients of AP were enrolled. Myocardial function was assessed by measuring CK-MB (creatine phosphokinase isoenzyme) and echocardiography at admission...
March 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29554539/circulating-inflammatory-proteins-and-gallbladder-cancer-potential-for-risk-stratification-to-improve-prioritization-for-cholecystectomy-in-high-risk-regions
#19
Jill Koshiol, Yu-Tang Gao, Amanda Corbel, Troy J Kemp, Ming-Chang Shen, Allan Hildesheim, Ann W Hsing, Asif Rashid, Bingsheng Wang, Ruth M Pfeiffer, Ligia A Pinto
BACKGROUND: Inflammatory proteins could help identify individuals most likely to have gallbladder cancer (GBC) among those waiting for cholecystectomy. METHODS: We analyzed 49 circulating inflammation-related proteins in 144 patients with GBC and 150 patients with gallstones. We calculated age- and sex-adjusted odds ratios (ORs) and 95% CIs for protein quantiles and GBC versus gallstones. Using proteins associated with early GBC (stage 1-2) that were selected in stepwise logistic regression, we created an inflammation score and explored the potential utility for risk stratification...
March 16, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29545607/hepatitis-c-virus-infection-increases-risk-of-gallstone-disease-in-elderly-chinese-patients-with-chronic-liver-disease
#20
Xu Li, Pujun Gao
We investigated possible links between the etiology of liver disease and gallstone risk in Chinese patients with chronic liver disease (CLD). We compared the outcomes of 267 Chinese CLD patients with gallstones and those of a control group of 1,015 CLD patients without gallstones. Logistic regression analyses adjusting for demographic features and other gallstone risk factors revealed that liver cirrhosis increased the risk of gallstone development twofold [adjusted odds ratio (AOR); 95% confidence interval (95% CI): 2...
March 15, 2018: Scientific Reports
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