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https://www.readbyqxmd.com/read/28919734/usefulness-of-the-desaturation-distance-ratio-from-the-six-minute-walk-test-for-patients-with-copd
#1
Yukari Fujimoto, Yutaro Oki, Masahiro Kaneko, Hideki Sakai, Shogo Misu, Takumi Yamaguchi, Yuji Mitani, Hisafumi Yasuda, Akira Ishikawa
PURPOSE: A straightforward, noninvasive method is needed to assess emphysema and pulmonary hypertension (PH) in COPD patients. The desaturation-distance ratio (DDR) is an index derived from the distance traveled and level of desaturation during a six-minute walk test (6MWT); it has previously been shown to be associated with percentage of forced expiratory volume in the first second of expiration (%FEV1.0) and percentage of diffusion capacity of the lung for carbon monoxide (%DLCO). The aim of this study was to examine the associations between DDR and emphysema and PH...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28919050/disease-and-treatment-factors-associated-with-lower-quality-of-life-scores-in-adults-with-multiple-endocrine-neoplasia-type-i
#2
Sneha Goswami, Benjamin J Peipert, Irene Helenowski, Susan E Yount, Cord Sturgeon
BACKGROUND: Physical and psychosocial morbidity of multiple endocrine neoplasia type-1 is ill-defined. How disease and treatment-related factors relate to patient-reported outcomes including health-related quality of life is unknown. We hypothesized that disease and treatment burden negatively impacts health-related quality of life in adults with multiple endocrine neoplasia type-1. METHODS: Adults (≥18 years) with multiple endocrine neoplasia type-1 completed an online survey of demographics, disease features, treatments, and Patient-Reported Outcomes Measurement Information System 29-item profile measure, and scores were compared with normative US data...
September 14, 2017: Surgery
https://www.readbyqxmd.com/read/28918645/increasing-availability-of-exposure-therapy-through-intensive-group-treatment-for-childhood-anxiety-and-ocd
#3
Stephen P H Whiteside, Julie E Dammann, Michael S Tiede, Bridget K Biggs, Andrea Hillson Jensen
Archival data were used to examine the feasibility of a 5-day, clinic-based, intensive exposure-based cognitive-behavioral group therapy for childhood anxiety disorders (CADs) and obsessive-compulsive disorder (OCD). Participants were 143 children (82 girls) aged 6 to 19 years ( M = 13.93 years, SD = 2.9 years) with CADs or OCD (or both) in 28 consecutive groups. Repeated-measures ANOVA in the subsample ( n = 57) with complete treatment data indicated positive change on all variables from pretreatment to posttreatment with few differences between CADs and OCD patients...
September 1, 2017: Behavior Modification
https://www.readbyqxmd.com/read/28916510/outcomes-of-telemedicine-video-conferencing-clinic-versus-in-person-clinic-follow-up-for-implantable-cardioverter-defibrillator-recipients
#4
Khidir Dalouk, Nainesh Gandhi, Peter Jessel, Karen MacMurdy, Ignatius Gerardo Zarraga, Michael Lasarev, Merritt Raitt
BACKGROUND: Implantable cardioverter-defibrillator (ICD) recipients require close follow-up that can be difficult for patients who have to travel long distances for clinic follow-up. We aimed to compare clinical outcomes between ICD patients followed-up in a telemedicine video-conferencing clinic (TMVC) and a conventional in-person clinic (CIC). We hypothesized that outcomes of patients followed in the TMVC are noninferior to the CIC. METHODS AND RESULTS: This retrospective study compares time to first appropriate ICD therapy, time to first inappropriate ICD therapy, time to first shock, and overall survival in patients followed in TMVC compared with CIC between 2001 and 2016...
September 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28916400/assessing-changes-in-the-activity-levels-of-breast-cancer-patients-during-radiation-therapy
#5
Colin E Champ, Nitin Ohri, Rainer J Klement, Matthew Cantor, Sushil Beriwal, Scott M Glaser, Ryan P Smith
BACKGROUND: Radiation therapy (RT) is often delivered after lumpectomy for women with breast cancer. A common perceived side effect of RT is fatigue, yet its exact effect on activity levels and sleep is unknown. In this study we analyzed the change in activity levels and sleep using an activity tracking device before, during, and after RT for women with early stage breast cancer and ductal carcinoma in situ who underwent adjuvant RT. PATIENTS AND METHODS: After institutional review board approval, activity levels were quantified before, during, and after RT with measurements of steps, miles walked, calories burned, and sleep metrics in 10 women fitted with activity trackers...
August 24, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28912012/the-effects-of-aerobic-exercise-on-depression-like-anxiety-like-and-cognition-like-behaviours-over-the-healthy-adult-lifespan-of-c57bl-6-mice
#6
Julie A Morgan, Gaurav Singhal, Frances Corrigan, Emily J Jaehne, Magdalene C Jawahar, Bernhard T Baune
Preclinical studies have demonstrated exercise improves various types of behaviours such as anxiety-like, depression-like, and cognition-like behaviours. However, these findings were largely conducted in studies utilising short-term exercise protocols, and the effects of lifetime exercise on these behaviours remain unknown. This study investigates the behavioural effects of lifetime exercise in normal healthy aging C57BL/6 mice over the adult lifespan. 12 week-old C57BL/6 mice were randomly assigned to voluntary wheel running or non-exercise (control) groups...
September 11, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28910302/a-look-back-on-how-far-to-walk-systematic-review-and-meta-analysis-of-physical-access-to-skilled-care-for-childbirth-in-sub-saharan-africa
#7
Kerry L M Wong, Lenka Benova, Oona M R Campbell
OBJECTIVES: To (i) summarize the methods undertaken to measure physical accessibility as the spatial separation between women and health services, and (ii) establish the extent to which distance to skilled care for childbirth affects utilization in Sub-Saharan Africa. METHOD: We defined spatial separation as the distance/travel time between women and skilled care services. The use of skilled care at birth referred to either the location or attendant of childbirth...
2017: PloS One
https://www.readbyqxmd.com/read/28898595/hematological-analysis-of-the-ascidian-botrylloides-leachii-savigny-1816-during-whole-body-regeneration
#8
Simon Blanchoud, Lisa Zondag, Miles D Lamare, Megan J Wilson
Whole-body regeneration (WBR)-the formation of an entire adult from only a small fragment of its own tissue-is extremely rare among chordates. Exceptionally, in the colonial ascidian Botrylloides leachii (Savigny, 1816) a fully functional adult is formed from their common vascular system after ablation of all adults from the colony in just 10 d, thanks to their high blastogenetic potential. While previous studies have identified key genetic markers and morphological changes, no study has yet focused on the hematological aspects of regeneration despite the major involvement of the remaining vascular system and the contained hemocytes in this process...
June 2017: Biological Bulletin
https://www.readbyqxmd.com/read/28891535/doppler-sonographic-evaluation-of-venogenic-extremity-swellings-analysis-of-170-patients-from-kano-nigeria
#9
A Ismail, A M Tabari, K Isyaku
INTRODUCTION: Deep venous thrombosis (DVT) is a serious problem that can potentially lead to many complications including life-threatening pulmonary arterial thrombosis. Screening and confirmation of the diagnosis are critical in the care of this condition. OBJECTIVES: The objective of this study was to evaluate the role of Doppler sonography in diagnosing DVT and to illustrate the pattern in 170 suspected cases from our local environment. MATERIALS AND METHODS: This study was conducted at our department over 18 months...
August 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28890389/motor-function-deficits-in-the-12-month-old-female-5xfad-mouse-model-of-alzheimer-s-disease
#10
T P O'Leary, A Robertson, P H Chipman, V F Rafuse, R E Brown
Motor problems occur early in some patients with Alzheimer's disease (AD) and as the disease progresses many patients develop motor dysfunction. Motor dysfunction has been reported in some mouse models of AD, including the 5xFAD mouse, thus this model may be particularly useful for studying motor dysfunction in AD. In order to determine the extent of motor dysfunction in these mice, we tested 11-13 month old female 5xFAD and wildtype (WT) control mice in a battery of motor behaviour tasks. The 5xFAD mice showed hind limb clasping, weighed less and had slower righting reflexes than WT mice...
September 7, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28888421/neural-crest-and-cancer-divergent-travelers-on-similar-paths
#11
REVIEW
Kristin L Gallik, Randall W Treffy, Lynne M Nacke, Kamil Ahsan, Manuel Rocha, Abigail Green-Saxena, Ankur Saxena
Neural crest cells are multipotent progenitors that dynamically interpret diverse microenvironments to migrate significant distances as a loosely associated collective and contribute to many tissues in the developing vertebrate embryo. Uncovering details of neural crest migration has helped to inform a general understanding of collective cell migration, including that which occurs during cancer metastasis. Here, we discuss several commonalities and differences of neural crest and cancer cell migration and behavior...
September 6, 2017: Mechanisms of Development
https://www.readbyqxmd.com/read/28887973/controlled-release-of-a-hydrophilic-drug-from-electrospun-amyloid-like-protein-blend-nanofibers
#12
Gözde Kabay, Ahmet Ersin Meydan, Gizem Kaleli Can, Ceylan Demirci, Mehmet Mutlu
In this study, a controlled drug release platform, amyloid-like bovine serum albumin (AL-BSA) with ampicillin sodium salt (amp), was developed. To develop this platform, 5%, 10%, and 20% (w/w) ratios of amp:BSA were used with electrospinning to prepare nanofibers with average diameters of 132±69, 159±60, and 179±42nm, respectively. Fourier transform infrared spectroscopy demonstrated that AL-BSA could entrap large amounts of drug inside the nanofibers, which was attributed to the antimicrobial activity of the released drug against Escherichia coli and Staphylococcus aureus...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28887470/direct-measurement-of-individual-phonon-lifetimes-in-the-clathrate-compound-ba7-81ge40-67au5-33
#13
Pierre-François Lory, Stéphane Pailhès, Valentina M Giordano, Holger Euchner, Hong Duong Nguyen, Reiner Ramlau, Horst Borrmann, Marcus Schmidt, Michael Baitinger, Matthias Ikeda, Petr Tomeš, Marek Mihalkovič, Céline Allio, Mark Robert Johnson, Helmut Schober, Yvan Sidis, Frédéric Bourdarot, Louis Pierre Regnault, Jacques Ollivier, Silke Paschen, Yuri Grin, Marc de Boissieu
Engineering lattice thermal conductivity requires to control the heat carried by atomic vibration waves, the phonons. The key parameter for quantifying it is the phonon lifetime, limiting the travelling distance, whose determination is however at the limits of instrumental capabilities. Here, we show the achievement of a direct quantitative measurement of phonon lifetimes in a single crystal of the clathrate Ba7.81Ge40.67Au5.33, renowned for its puzzling 'glass-like' thermal conductivity. Surprisingly, thermal transport is dominated by acoustic phonons with long lifetimes, travelling over distances of 10 to 100 nm as their wave-vector goes from 0...
September 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28886977/an-optimization-model-for-collection-haul-transfer-treatment-and-disposal-of-infectious-medical-waste-application-to-a-greek-region
#14
Gerasimos Mantzaras, Evangelos A Voudrias
The objective of this work was to develop an optimization model to minimize the cost of a collection, haul, transfer, treatment and disposal system for infectious medical waste (IMW). The model calculates the optimum locations of the treatment facilities and transfer stations, their design capacities (t/d), the number and capacities of all waste collection, transport and transfer vehicles and their optimum transport path and the minimum IMW management system cost. Waste production nodes (hospitals, healthcare centers, peripheral health offices, private clinics and physicians in private practice) and their IMW production rates were specified and used as model inputs...
September 5, 2017: Waste Management
https://www.readbyqxmd.com/read/28885499/a-concentric-neighborhoods-solution-to-disparity-in-liver-access-that-contains-current-unos-districts
#15
Sanjay Mehrotra, Vikram Kilambi, Kevin Bui, Richard Gilroy, Sophoclis P Alexopoulos, David S Goldberg, Daniela P Ladner, Goran B Klintmalm
BACKGROUND: Policymakers are deliberating reforms to reduce geographic disparity in liver allocation. Public comments and the UNOS Liver and Intestinal Committee have expressed interest in refining the neighborhoods approach. Share 35 and Share 15 policies affect geographic disparity. METHODS: We construct concentric neighborhoods superimposing the current 11 regions. Employing concepts from concentric circles, we construct neighborhoods for each DSA that consider all DSAs within 400, 500, or 600 miles as neighbors...
September 6, 2017: Transplantation
https://www.readbyqxmd.com/read/28882993/the-condensin-complex-is-a-mechanochemical-motor-that-translocates-along-dna
#16
Tsuyoshi Terakawa, Shveta Bisht, Jorine M Eeftens, Cees Dekker, Christian H Haering, Eric C Greene
Condensin plays crucial roles in chromosome organization and compaction, but the mechanistic basis for its functions remains obscure. Here, we use single-molecule imaging to demonstrate that Saccharomyces cerevisiae condensin is a molecular motor capable of ATP hydrolysis-dependent translocation along double-stranded DNA. Condensin's translocation activity is rapid and highly processive, with individual complexes traveling an average distance of ≥10 kilobases at a velocity of ~60 base pairs per second. Our results suggest that condensin may take steps comparable in length to its ~50-nanometer coiled-coil subunits, suggestive of a translocation mechanism that is distinct from any reported DNA motor protein...
September 7, 2017: Science
https://www.readbyqxmd.com/read/28882593/real-time-subpixel-accuracy-tracking-of-single-mitochondria-in-neurons-reveals-heterogeneous-mitochondrial-motion
#17
Adolfo Alsina, Wu Ming Lai, Wai Kin Wong, Xianan Qin, Min Zhang, Hyokeun Park
Mitochondria are essential for cellular survival and function. In neurons, mitochondria are transported to various subcellular regions as needed. Thus, defects in the axonal transport of mitochondria are related to the pathogenesis of neurodegenerative diseases, and the movement of mitochondria has been the subject of intense research. However, the inability to accurately track mitochondria with subpixel accuracy has hindered this research. Here, we report an automated method for tracking mitochondria based on the center of fluorescence...
September 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28882273/school-transportation-mode-by-distance-between-home-and-school-united-states-consumerstyles-2012
#18
Laurie F Beck, Daniel D Nguyen
INTRODUCTION: Motor-vehicle crashes are a leading cause of death among children in the United States, and almost one-fourth of all trips by school-aged children are trips to and from school. This study sought to determine how children (5-18years) travel to and from school and, among those living ≤1mile of school, to explore the role of school bus service eligibility on school travel mode. METHODS: We used national 2012 survey data to determine prevalence of usual school travel mode, stratified by distance from school...
September 2017: Journal of Safety Research
https://www.readbyqxmd.com/read/28879832/supermarket-access-transport-mode-and-bmi-the-potential-for-urban-design-and-planning-policy-across-socio-economic-areas
#19
Maureen Murphy, Mohammad Javad Koohsari, Hannah Badland, Billie Giles-Corti
OBJECTIVE: To investigate dietary intake, BMI and supermarket access at varying geographic scales and transport modes across areas of socio-economic disadvantage, and to evaluate the implementation of an urban planning policy that provides guidance on spatial access to supermarkets. DESIGN: Cross-sectional study used generalised estimating equations to investigate associations between supermarket density and proximity, vegetable and fruit intake and BMI at five geographic scales representing distances people travel to purchase food by varying transport modes...
September 7, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28879151/programmatic-implications-of-implementing-the-relational-algebraic-capacitated-location-racl-algorithm-outcomes-on-the-allocation-of-laboratory-sites-test-volumes-platform-distribution-and-space-requirements
#20
Naseem Cassim, Honora Smith, Lindi M Coetzee, Deborah K Glencross
INTRODUCTION: CD4 testing in South Africa is based on an integrated tiered service delivery model that matches testing demand with capacity. The National Health Laboratory Service has predominantly implemented laboratory-based CD4 testing. Coverage gaps, over-/under-capacitation and optimal placement of point-of-care (POC) testing sites need investigation. OBJECTIVES: We assessed the impact of relational algebraic capacitated location (RACL) algorithm outcomes on the allocation of laboratory and POC testing sites...
2017: African Journal of Laboratory Medicine
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