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Photodynamic therapy

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https://www.readbyqxmd.com/read/28933857/giant-enhancement-of-cathodoluminescence-of-monolayer-transitional-metal-dichalcogenides-semiconductors
#1
Shoujun Zheng, Jinkyu So, Fucai Liu, Zheng Liu, Nikolay I Zheludev, Hong Jin Fan
Monolayer two-dimensional transitional metal dichalcogenides, such as MoS2, WS2 and WSe2, are direct band gap semiconductors with large exciton binding energy. They attract growing attentions for opto-electronic applications including solar cells, photo-detectors, light-emitting diodes and photo-transistors, capacitive energy storage, photodynamic cancer therapy and sensing on flexible platforms. While light-induced luminescence has been widely studied, luminescence induced by injection of free electrons could promise another important applications of these new materials...
September 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/28933502/synthesis-and-evaluation-of-new-5-aminolevulinic-acid-derivatives-as-prodrugs-of-protoporphyrin-for-photodynamic-therapy
#2
Wei Zhu, Ying-Hua Gao, Chun-Hong Song, Zhi-Bin Lu, Tabbisa Namulinda, Yi-Ping Han, Yi-Jia Yan, Lai-Xing Wang, Zhi-Long Chen
Protoporphyrin IX (PpIX) is used as a photosensitizer in the photodynamic diagnosis (PDD) and photodynamic therapy (PDT) of cancer and is synthesized intracellularly from 5-aminolevulinic acid (5-ALA) precursors. Thirteen novel 5-ALA derivatives were designed and synthesized appropriately with tailored hydrophilicity and lipophilicity. The generation of PpIX was detected and their antitumor activity in vitro and in vivo was also investigated. It was shown that compounds 9b-c, 11b-c and 13a displayed a characteristic long wavelength absorption peak at 593 nm after 5 h incubation in mice fibrosarcoma S180 cells...
September 21, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28933294/biodegradable-black-phosphorus-based-nanomaterials-in-biomedicine-theranostic-applications
#3
Zhen Wang, Zhiming Liu, Chengkang Su, Biwen Yang, Xixi Fei, Yi Li, Yuqing Hou, Henan Zhao, Yanxian Guo, Zhengfei Zhuang, Huiqing Zhong, Zhouyi Guo
Ascribe to the unique two-dimensional planar nanostructure with exceptional physical and chemical properties, black phosphorous (BP) as the emerging inorganic two-dimensional nanomaterial with high biocompatibility and degradability has been becoming one of the most promising materials of great potentials in biomedicine. The exfoliated BP sheets possess ultra-high surface area available for valid bio-conjugation and molecular loading for chemotherapy. Utilizing the intrinsic near-infrared optical absorbance, BP-based photothermal therapy in vivo, photodynamic therapy and biomedical imaging has been realized, achieving unprecedented anti-tumor therapeutic efficacy in animal experiments...
September 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28933283/organic-nanotheranostics-for-photoacoustic-imaging-guided-phototherapy
#4
Houjuan Zhu, Chen Xie, Peng Chen, Kanyi Pu
Phototherapies including photothermal therapy (PTT) and photodynamic therapy (PDT) have emerged as one of the avant-garde strategies for cancer treatment. Photoacoustic (PA) imaging is a new hybrid imaging modality that shows great promise for real-time in vivo monitoring of biological processes with deep tissue penetration and high spatial resolution. To enhance therapeutic efficiency and reduce side effects, it is necessary to explore the combination of cancer therapy and diagnosis. Nanotheranostics composed of PTT/PDT and PA imaging are emerging to provide unprecedented advantages in accelerating cancer theranostics...
September 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28932570/the-technique-of-endoscopic-airway-tumor-treatment
#5
REVIEW
Simone Scarlata, Lello Fuso, Gabriele Lucantoni, Francesco Varone, Daniele Magnini, Raffaele Antonelli Incalzi, Gianni Galluccio
More than half of primary lung cancers are not resectable at diagnosis and 40% of deaths may be secondary to loco-regional disease. Many of these patients suffer from symptoms related to airways obstruction. Indications for therapeutic endoscopic treatment are palliation of dyspnea and other obstructive symptoms in advanced cancerous lesions and cure of early lung cancer. Bronchoscopic management is also indicated for all those patients suffering from benign or minimally invasive neoplasm who are not suitable for surgery due to their clinical conditions...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932569/endobronchial-ultrasound-guidance-for-interstitial-photodynamic-therapy-of-locally-advanced-lung-cancer-a-new-interventional-concept
#6
Kassem Harris, Emily Oakley, David Bellnier, Gal Shafirstein
Recent advances in interventional pulmonology led to a significant expansion of the diagnostic and therapeutic role of endobronchial ultrasound. In this paper, we describe a new concept for using endobronchial ultrasound to guide interstitial photodynamic therapy (PDT). For this purpose, we conducted in vitro and in vivo experiments using a phantom and animal models, respectively. A new 0.5 mm optical fiber, with cylindrical diffuser end, was used to deliver the therapeutic light through the 21-gauge endobronchial ultrasound needle...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28927532/beyond-mouse-cancer-models-three-dimensional-human-relevant-in-vitro-and-non-mammalian-in-vivo-models-for-photodynamic-therapy
#7
REVIEW
Malgorzata Kucinska, Marek Murias, Patrycja Nowak-Sliwinska
The proper design of experiments is a critical step for each study in order to obtain reproducible and reliable data. Taking into account constant competitiveness in the quickly developing biomedical sciences and the availability of sophisticated techniques, the choice and establishment of an experimental model system are essential for a successful research project. Currently, various sophisticated in vitro and in vivo models are being designed and developed in order to replace the use of mammalian models to investigate the mechanisms of action, activity and properties of novel compounds or treatment modalities...
July 2017: Mutation Research
https://www.readbyqxmd.com/read/28926732/multifunctional-mesoporous-zro2-encapsulated-upconversion-nanoparticles-for-mild-nir-light-activated-synergistic-cancer-therapy
#8
Lili Feng, Shili Gai, Fei He, Yunlu Dai, Chongna Zhong, Piaoping Yang, Jun Lin
Desirable nanosystem that could not only deliver drugs safely and effectively into tumor sites, but also be expected to serve as photosensitizer to realize the photodynamic therapeutic function, would be of great significance in the synergistic cancer therapy. To perform this task, a multifunctional nanosystem has been developed for markedly enhanced cancer therapeutic efficacy by loading chemotherapy agent (doxorubicin hydrochloride, DOX) and photosensitive drug chlorin e6 (Ce6) into the channels of mesoporous zirconium dioxide (ZrO2) layer which coats on Nd(3+)-doped upconversion nanoparticles (UCNPs)...
September 13, 2017: Biomaterials
https://www.readbyqxmd.com/read/28925941/cold-atmospheric-plasma-in-the-treatment-of-osteosarcoma
#9
REVIEW
Denis Gümbel, Sander Bekeschus, Nadine Gelbrich, Matthias Napp, Axel Ekkernkamp, Axel Kramer, Matthias B Stope
Human osteosarcoma (OS) is the most common primary malignant bone tumor occurring most commonly in adolescents and young adults. Major improvements in disease-free survival have been achieved by implementing a combination therapy consisting of radical surgical resection of the tumor and systemic multi-agent chemotherapy. However, long-term survival remains poor, so novel targeted therapies to improve outcomes for patients with osteosarcoma remains an area of active research. This includes immunotherapy, photodynamic therapy, or treatment with nanoparticles...
September 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28924442/laser-induced-choroidal-neovascularizations-clinical-study-of-3-cases
#10
Wipada Laovirojjanakul, Thuss Sanguansak, Yosanan Yospaiboon, Supat Sinawat, Suthasinee Sinawat
BACKGROUND: We report 3 patients with laser-induced choroidal neovascularization (CNV). METHOD: Retrospective, observational case series. Medical charts and photographs were reviewed. RESULTS: Two patients with central serous chorioretinopathy who developed iatrogenic CNV after focal laser photocoagulation were treated with intravitreal ranibizumab injections. One patient with CNV secondary to thermal laser photocoagulation for diabetic macular edema was treated with photodynamic therapy (PDT)...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28924376/verteporfin-inhibits-cell-proliferation-and-induces-apoptosis-in-human-leukemia-nb4-cells-without-light-activation
#11
Min Chen, Liang Zhong, Shi-Fei Yao, Yi Zhao, Lu Liu, Lian-Wen Li, Ting Xu, Liu-Gen Gan, Chun-Lan Xiao, Zhi-Ling Shan, Bei-Zhong Liu
Background and Aims: Verteporfin (VP), clinically used in photodynamic therapy for neovascular macular degeneration, has recently been proven a suppressor of yes-associated protein (YAP) and has shown potential in anticancer treatment. However, its anti-human leukemia effects in NB4 cells remain unclear. In this study, we investigated the effects of VP on proliferation and apoptosis in human leukemia NB4 cells. Methods: NB4 cells were treated with VP for 24 h. The effects of VP on cell proliferation were determined using a Cell-Counting Kit-8 assay (CCK-8) assay and colony forming assay...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28923402/synergistic-chemo-photodynamic-therapy-by-big-small-combo-nanoparticles-sequential-release-system
#12
Li Fan, Saisai Zhao, Xin Jin, Yongsheng Zhang, Chaojun Song, Hong Wu
Chemo-photodynamic combination has been manifested great potential for synergistic cancer therapy. Moreover, the synergistic efficacy could be significantly enhanced by well designed sequential release manner of photosensitizers (PSs). Here we propose a "Big & small combo nanoparticles (NPbig&small)" system for double loading PSs methylene blue (MB) and single absorbing chemotherapeutics drug Gemcitabine hydrochloride (GM(.)HCl). The "grown-in" MB from NPbig&small show two-peak sequential release profile, significantly improve the absorbed chemo therapeutic efficacy of GM(...
September 15, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28919756/polymeric-mixed-micelles-loaded-mitoxantrone-for-overcoming-multidrug-resistance-in-breast-cancer-via-photodynamic-therapy
#13
Zeyong Li, Yuee Cai, Yiqiao Zhao, Hua Yu, Haiyu Zhou, Meiwan Chen
Mitoxantrone (MIT) is an anticancer agent with photosensitive properties that is commonly used in various cancers. Multidrug resistance (MDR) effect has been an obstacle to using MIT for cancer therapy. Photochemical internalization, on account of photodynamic therapy, has been applied to improve the therapeutic effect of cancers with MDR effect. In this study, an MIT-poly(ε-caprolactone)-pluronic F68-poly(ε-caprolactone)/poly(d,l-lactide-co-glycolide)-poly(ethylene glycol)-poly(d,l-lactide-co-glycolide) (MIT-PFP/PPP) mixed micelles system was applied to reverse the effect of MDR in MCF-7/ADR cells via photochemical reaction when exposed to near-infrared light...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28919324/pretreatment-of-skin-using-an-abrasive-skin-preparation-pad-a-microneedling-device-or-iontophoresis-improves-absorption-of-methyl-aminolevulinate-in-ex-vivo-human-skin
#14
Hanan Osman-Ponchet, Alexandre Gaborit, Karine Sevin, Christophe Bianchi, Jean-Michel Linget, Claire E Wilson, Guy Bouvier
BACKGROUND: Pretreatment of skin to remove scales/crusts and roughen the surface is essential to enhance the penetration of topically applied methyl aminolevulinate (MAL) prior to photodynamic therapy and to permit daylight to access all parts of the skin lesions. Numerous procedures of skin preparation are currently available. This study compared the in vitro penetration of MAL into ex vivo human skin pretreated with skin preparation pad abrasion or a microneedling device, and evaluated the effectiveness of an iontophoretic device in delivering MAL into ex vivo human skin...
September 12, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28918670/ph-sensitive-metal-phenolic-network-capsules-for-targeted-photodynamic-therapy-against-cancer-cells
#15
Yuanqing Wei, Zhenzhen Wei, Peicheng Luo, Wei Wei, Songqin Liu
Photodynamic therapy (PDT) is an effective and promising method for cancer treatment, which is proposed for more than one century. However, the specific delivery of photosensitizer to target carcinoma cells to reduce the side effect is still a great challenge. This work provides a strategy to deliver photosensitizers to cancer cells by utilizing pH-sensitive polyethylene glycol metal-phenolic network (PEG-MPN) capsules to encapsulate haematoporphyrin monomethyl ether (HMME). With the assistance of folic acid (FA), HMME-doped PEG-MPN capsules (MPN@HMMEs) accumulate in carcinoma cells selectively followed by releasing HMME in the lysosomes because of the physiologically relevant acidic pH environment...
September 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28918177/photodynamic-therapy-in-oral-potentially-malignant-disorders-critical-literature-review-of-existing-protocols
#16
REVIEW
Jéssica Araújo Figueira, Vanessa Cristina Veltrini
INTRODUCTION: Oral cancer is a serious public health issue. Apart from its high rate of prevalence, incidence and mortality, it can often result in more complex and expensive treatment when diagnosed late. Potentially malignant disorders (PMDs) can precede oral cancer, and are usually treated by surgical excision. However, in many cases patients are elderly and multiple interventions may be required. Photodynamic therapy (PDT) is a simple alternative, which has been successfully used in the treatment of oral PMDs...
September 13, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28916656/chemotherapy-induced-macrophage-infiltration-into-tumors-enhances-nanographene-based-photodynamic-therapy
#17
Yang Zhao, Chenran Zhang, Liquan Gao, Xinhe Yu, Jianhao Lai, Dehua Lu, Rui Bao, Yanpu Wang, Bing Jia, Fan Wang, Zhaofei Liu
Increased recruitment of tumor-associated macrophages (TAM) to tumors following chemotherapy promotes tumor resistance and recurrence and correlates with poor prognosis. TAM depletion suppresses tumor growth, but is not highly effective due to the effects of tumorigenic mediators from other stromal sources. Here we report that adoptive macrophage transfer led to a dramatically enhanced photodynamic therapy (PDT) effect of 2-(1-hexyloxyethyl)-2-devinyl pyropheophor-bide-alpha (HPPH)-coated polyethylene glycosylated nanographene oxide [GO(HPPH)-PEG] by increasing its tumor accumulation...
September 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28916141/in-vivo-multimodal-tumor-imaging-and-photodynamic-therapy-with-novel-theranostic-agents-based-on-the-porphyrazine-framework-chelated-gadolinium-iii-cation
#18
Diana V Yuzhakova, Svetlana A Lermontova, Ilya S Grigoryev, Maria S Muravieva, Alena I Gavrina, Marina V Shirmanova, Irina V Balalaeva, Larisa G Klapshina, Elena V Zagaynova
BACKGROUND: A promising strategy for cancer diagnosis and therapy is the development of an agent for multimodal imaging and treatment. In the present paper we report on two novel multifunctional agents prepared on the porphyrazine pigment platform using a gadolinium (III) cation chelated by red-fluorescent tetrapyrrole macrocycles (GdPz1 and GdPz2). METHODS: Spectral and magnetic properties of the compounds were analyzed. Monitoring of GdPz1 and GdPz2 accumulation in the murine colon carcinoma CT26 was performed in vivo using fluorescence imaging and MRI...
September 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28915492/enhancement-of-5-aminolevulinic-acid-phototoxicity-by-encapsulation-in-polysaccharides-based-nanocomplexes-for-photodynamic-therapy-application
#19
Antonio Di Martino, Alena Pavelkova, Pavel S Postnikov, Vladimir Sedlarik
Polysaccharides based nanocomplexes have been developed for encapsulation, controlled delivery and to enhance the phototoxicity of the photosensitizer 5-aminolevulinic acid for application in photodynamic therapy. The nanocomplexes were prepared by coacervation in a solvent free environment using chitosan as polycation while alginic and polygalacturonic acid as polyanions. The complexes showed average dimension in the range 90-120nm, good stability in simulated physiological media and high drug encapsulation efficiency, up to 800μg per mg of carrier...
August 8, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28915410/aiegens-for-biological-process-monitoring-and-disease-theranostics
#20
REVIEW
Xinggui Gu, Ryan T K Kwok, Jacky W Y Lam, Ben Zhong Tang
Biological processes are of great significance for the normal physiological functions of living organisms and closely related to the health. Monitoring of biological processes and diagnosis of diseases based on fluorescent techniques would provide comprehensive insight into mechanism of life and pathogenesis of diseases, precisely guiding therapeutic effect in theranostics. It largely relied on fluorophores with the properties of excellent photostability, large Stokes shift, high signal-to-noise ratio and free of aggregation-caused quenching (ACQ) effect...
September 4, 2017: Biomaterials
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