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Photodynamic therapy

Elisabetta Sorbellini, Mariangela Rucco, Fabio Rinaldi
Benefit deriving from the use of light is known since ancient time, but, only in the last decades of twentieth century, we witnessed the rapid expansion of knowledge and techniques. Light-emitted diode (LED)-based devices represent the emerging and safest tool for the treatment of many conditions such as skin inflammatory conditions, aging, and disorders linked to hair growth. The present work reviews the current knowledge about LED-based therapeutic approaches in different skin and hair disorders. LED therapy represents the emerging and safest tool for the treatment of many conditions such as skin inflammatory conditions, aging, and disorders linked to hair growth...
July 14, 2018: Lasers in Medical Science
Wei Deng, Wenjie Chen, Sandhya Clement, Anna Guller, Zhenjun Zhao, Alexander Engel, Ewa M Goldys
Liposomes have been well established as an effective drug delivery system, due to simplicity of their preparation and unique characteristics. However conventional liposomes are unsuitable for the on-demand content release, which limits their therapeutic utility. Here we report X-ray-triggerable liposomes incorporating gold nanoparticles and photosensitizer verteporfin. The 6 MeV X-ray radiation induces verteporfin to produce singlet oxygen, which destabilises the liposomal membrane and causes the release of cargos from the liposomal cavity...
July 13, 2018: Nature Communications
Hasan Hoseinpour Jajarm, Reza Asadi, Erfan Bardideh, Hooman Shafaee, Yeganeh Khazaei, Maryam Emadzadeh
BACKGROUND: Oral lichen planus (OLP) is a chronic immune-mediated disorder that inflicts oral mucosa in 0.5-2% of the population. Surgery, photodynamic therapy, laser therapy and most commonly pharmacological therapy (like corticosteroids) has been used for treating OLP. New phototherapy approaches have been shown to have positive effects on treating some oral lesions and the aim of our study was to assess the effects of different phototherapy treatments on OLP. METHODS: We conducted a comprehensive electronic search using the determined search strategy in MEDLINE, EMBASE and CENTRAL electronic databases...
July 10, 2018: Photodiagnosis and Photodynamic Therapy
Zhikuan Chen, Lanlan Liu, Ruijing Liang, Zhenyu Luo, Huamei He, Zhihao Wu, Hao Tian, Mingbin Zheng, Yifan Ma, Lintao Cai
An ideal cancer therapeutic strategy is expected to possess potent ability that not only can ablate primary tumor, but also can prevent the distance metastasis and relapse. In this study, human serum albumin was hybridized with hemoglobin by intermolecular disulfide bonds to develop a hybrid protein oxygen nanocarrier with chlorine e6 encapsulated (C@HPOC) for oxygen self-sufficient photodynamic therapy (PDT). C@HPOC realized the tumor-targeted co-delivery of photosensitizer and oxygen, which remarkably relieved tumor hypoxia...
July 13, 2018: ACS Nano
Qianyu Zhang, Libo Li
Photodynamic therapy (PDT) has attracted widespread attention in recent years as a non-invasive and highly selective approach for cancer treatment. PDT involves the activation of a photosensitizer by an appropriate wavelength of light, generating transient levels of reactive oxygen species (ROS). However, the utilization of PDT against deep tumors has been greatly limited by insufficient luminous flux and the occurrence of peripheral tissue damage. Therefore, experts have begun to explore whether the combination of PDT with other treatments can improve its efficacy...
May 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Chendong Ji, Qin Gao, Xinghua Dong, Wenyan Yin, Zhanjun Gu, Zhihua Gan, Yuliang Zhao, Meizhen Yin
Fluorescent dyes with multi-functionality are of great interest for photo-based cancer theranostics. However, their low singlet oxygen quantum yield impedes their potential applications for photodynamic therapy (PDT). Herein, we report a molecular self-assembly strategy for the nanodrug with a remarkably enhanced photodynamic effect based on a dye-chemodrug conjugate. The self-assembled nanodrug possesses an increased intersystem crossing rate due to the aggregation of dye, leading to a distinct singlet oxygen quantum yield (Φ(1O2))...
July 12, 2018: Angewandte Chemie
Katriann Arja, Mathias Elgland, Hanna Appelqvist, Peter Konradsson, Mikael Lindgren, K Peter R Nilsson
Small molecules with modalities for a variety of imaging techniques as well as therapeutic activity are essential, as such molecules render opportunities to simultaneously conduct diagnosis and targeted therapy, so called theranostics. In this regard, glycoporphyrins have proven useful as theranostic agents towards cancer, as well as noncancerous conditions. Herein, the synthesis and characterization of heterobifunctional glycoconjugated porphyrins with two different sugar moieties, a common monosaccharide at three sites, and a 2-fluoro-2-deoxy glucose (FDG) moiety at the fourth site are presented...
July 2018: ChemistryOpen
Katriann Arja, Mathias Elgland, Hanna Appelqvist, Peter Konradsson, Mikael Lindgren, K Peter R Nilsson
Invited for this month's cover picture is the group of Professor Peter Nilsson at the Department of Physics, Chemistry and Biology at Linköping University (Sweden). The cover picture shows a fluoro-glycoporphyrin that selectively targets cancer cells. The selectivity towards cancer cells are afforded due to proper functionalization of the porphyrin scaffold with specific carbohydrates, and the cancer cells can be visualized because of the intrinsic fluorescence from the porphyrin. The molecule also exhibits properties for photodynamic therapy and the incorporation of fluorine, in the form of 2-fluoro-2-deoxy glucose (FDG), offers the possibility to apply these compounds as 18F positron emission tomography (PET) tracers...
July 2018: ChemistryOpen
Eleftherios I Agorogiannis, Ian A Pearce, Sohraab Yadav, David G Parry, Nicholas A V Beare
PURPOSE: To describe treatment outcomes in a cohort of Caucasian patients with polypoidal choroidal vasculopathy (PCV). METHODS: Clinical charts from 48 eyes of 45 Caucasian patients with PCV were retrospectively reviewed. All cases were diagnosed with indocyanine green angiography. Best corrected visual acuity (BCVA) and optical coherence tomography (OCT) imaging were analyzed at baseline and final follow-up. RESULTS: Eyes were treated with a combination of verteporfin photodynamic therapy (PDT) and anti-vascular endothelial growth factor (VEGF) (n = 24), or PDT monotherapy (n = 9), or anti-VEGF monotherapy (n = 8), or no treatment (n = 7)...
July 12, 2018: Eye
Jingyao Sun, Semen Kormakov, Ying Liu, Yao Huang, Daming Wu, Zhaogang Yang
Photodynamic therapy (PDT) is able to non-invasively treat and diagnose various cancers and nonmalignant diseases by combining light, oxygen, and photosensitizers (PSs). However, the application of PDT is hindered by poor water solubility and limited light-penetration depth of the currently available photosensitizers (PSs). Water solubility of PSs is crucial for designing pharmaceutical formulation and administration routes. Wavelength of light source at visible range normally has therapeutic depth less than 1 mm...
July 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Fangyuan Li, Yang Du, Jianan Liu, Heng Sun, Jin Wang, Ruiqing Li, Dokyoon Kim, Taeghwan Hyeon, Daishun Ling
Upconversion nanoparticle (UCNP)-mediated photodynamic therapy has shown great effectiveness in increasing the tissue-penetration depth of light to combat deep-seated tumors. However, the inevitable phototoxicity to normal tissues resulting from the lack of tumor selectivity remains as a major challenge. Here, the development of tumor-pH-sensitive photodynamic nanoagents (PPNs) comprised of self-assembled photosensitizers grafted pH-responsive polymeric ligands and UCNPs is reported. Under neutral pH conditions, photosensitizers aggregated in the PPNs are self-quenched; however, upon entry into a tumor microenvironment with lower pH, the PPNs not only exhibit enhanced tumor-cell internalization due to charge reversal but also are further disassembled into well-dispersed nanoparticles in the endo/lysosomes of tumor cells, enabling the efficient activation of photosensitizers...
July 12, 2018: Advanced Materials
Mubarak A AlAmri, Hachemi Kadri, Mark Jeeves, Luke J Alderwick, Youcef Mehellou
SPAK and OSR1 are two serine/threonine protein kinases that play important key roles in regulating ion homeostasis. Various SPAK and OSR1 mouse models exhibited reduced blood pressure. Herein, we report the discovery of Verteporfin, a photosensitizing agent used in photodynamic therapy, as a potent inhibitor of SPAK and OSR1 kinases. We show that Verteporfin binds the kinase domains of SPAK and OSR1 and inhibit their catalytic activity in an ATP-independent manner. In cells, Verteporfin was able to suppress the phosphorylation of the ion co-transporter NKCC1, a downstream physiological substrate of SPAK and OSR1 kinases...
July 12, 2018: Chembiochem: a European Journal of Chemical Biology
Qiguang Zang, Jiayi Yu, Wenbin Yu, Jun Qian, Rongrong Hu, Ben Zhong Tang
Photodynamic therapy has proved to be an effective strategy for cancer therapy, and advanced photosensitizers for image-guided photodynamic therapy require biocompatibility, intense absorption, high ROS generation efficiency, phototoxicity, low irradiation power density and efficient emission. In this work, four red emissive azabenzanthrone derivatives have been designed and synthesized, which generally exhibit efficient aggregated state emission. Through structural optimization, 3-diphenylamino-11-azabenzanthrone was found to show satisfactory photo-induced ROS generation and high emission efficiency in the aggregated state...
June 21, 2018: Chemical Science
Xiaoqing Hu, Ying-Ying Huang, Yuguang Wang, Xiaoyuan Wang, Michael R Hamblin
Biofilm describes a microbially-derived sessile community in which microbial cells are firmly attached to the substratum and embedded in extracellular polymeric matrix. Microbial biofilms account for up to 80% of all bacterial and fungal infections in humans. Biofilm-associated pathogens are particularly resistant to antibiotic treatment, and thus novel antibiofilm approaches needed to be developed. Antimicrobial Photodynamic therapy (aPDT) had been recently proposed to combat clinically relevant biofilms such as dental biofilms, ventilator associated pneumonia, chronic wound infections, oral candidiasis, and chronic rhinosinusitis...
2018: Frontiers in Microbiology
Gihan Mahmoud, Jarmila Jedelská, Samia Mohamed Omar, Boris Strehlow, Marc Schneider, Udo Bakowsky
Photodynamic therapy (PDT) that involves ergonomically delivered light in the presence of archetypical photosensitizer such as Protoporphyrin IX (PpIX) is a time-honored missile strategy in cancer therapeutics. Yet, the premature release of PpIX is one of the most abundant dilemma encounters the therapeutic outcomes of PDT due to associated toxicity and redistribution to serum proteins. In this study, ultrastable tetraether lipids (TELs) based liposomes were developed. PpIX molecules were identified to reside physically in the monolayer; thereby the inherent π-π stacking that leads to aggregation of PpIX in aqueous milieu was dramatically improved...
November 2018: Drug Delivery
Yun Wu, Peiru Wang, Linglin Zhang, Bo Wang, Xiuli Wang
BACKGROUND: Bowen's disease (BD) is treated effectively with 5-aminolevulinic acid (ALA)-photodynamic therapy (ALA-PDT). Plum-blossom needling (PBN) may enhance topical drug delivery. OBJECTIVE: To compare the effects of and adverse reactions to PBN and ALA-PDT of BD with those associated with ALA-PDT alone. MATERIALS AND METHODS: Forty-three lesions from 24 patients were randomly assigned to 2 groups. The PBN-ALA-PDT group underwent vertical skin tapping with PBN before applying 10% ALA cream and narrow-band light-emitting diode irradiation (λ = 633 ± 10 nm; 100-200 J/cm)...
July 9, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
C Nicklas, R Rubio, C Cárdenas, A Hasson
BACKGROUND: Although progress has been made in the study of photodynamic therapy for acne, studies using current recommended therapies as active comparators are lacking. METHODS: Randomized, controlled trial involving 46 patients with moderate inflammatory facial acne, 23 patients received two sessions of PDT separated by 2 weeks (ALA20% incubated 1.5 hours before red light irradiation with 37J/cm2 fluence) and 23 patients received doxycycline 100mg/day plus adapalene gel 0...
July 11, 2018: Photodermatology, Photoimmunology & Photomedicine
Sadao Kaneko, Shin Fujimoto, Hideshi Yamaguchi, Toru Yamauchi, Tetsuya Yoshimoto, Koichi Tokuda
Recently, the clinical applications of photodynamic therapy (PDT) in the management of malignant brain tumors have attracted significant attention. Meta-analysis of the observational studies on this treatment in high-grade gliomas (Eljamel, 2010) included more than 1,000 patients and reported median survival in cases of newly diagnosed and recurrent glioblastoma multiforme (GBM) of 16.1 and 10.3 months, respectively. In some series, increase in the long-term survival rates was also observed. Few controlled trials demonstrated statistically significant impact of PDT on prolongation of survival in patients with GBM in comparison to conventional management...
2018: Progress in Neurological Surgery
Takahiro Fujishiro, Naosuke Nonoguchi, Marat Pavliukov, Naoki Ohmura, Yangtae Park, Yoshinaga Kajimoto, Toshihisa Ishikawa, Ichiro Nakano, Toshihiko Kuroiwa
BACKGROUND: Glioblastoma (GBM) is a highly malignant lethal brain cancer. Accumulated evidence suggests that elevated resistance of GBM to both chemo- and radio-therapy is, at least in part, due to the presence of a small population of glioma stem cells (GSC). In the present study, we aimed to determine the sensitivity of GSCs to 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT). METHODS: For this purpose, we established GSC-enriched cell cultures (termed glioma stem-like cells or GSLCs) from A172 human GBM cell line...
July 7, 2018: Photodiagnosis and Photodynamic Therapy
Okhil Kumar Nag, Jawad Naciri, Jeffrey S Erickson, Eunkeu Oh, James B Delehanty
Current challenges in photodynamic therapy (PDT) include both the targeted delivery of the photosensitizer (PS) to the desired cellular location and the maintenance of PS efficacy. Zinc phthalocyanine (ZnPc), a macrocyclic porphyrin and a potent PS for PDT, undergoes photoexcitation to generate reactive singlet oxygen that kills cells efficiently, particularly when delivered to the plasma membrane. Like other commonly-employed PS, ZnPc is highly hydrophobic and prone to self-aggregation in aqueous biological media...
July 10, 2018: Bioconjugate Chemistry
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