keyword
MENU ▼
Read by QxMD icon Read
search

cardiac troponin T

keyword
https://www.readbyqxmd.com/read/29448046/diurnal-variation-in-admission-troponin-concentrations-in-patients-with-chest-pain-in-the-emergency-department
#1
Andreas Roos, Martin J Holzmann
BACKGROUND: Recent studies have suggested that there may be large diurnal variation in cardiac troponin T (cTnT) concentrations measured with a high sensitive assay. OBJECTIVE: To investigate if clinically relevant diurnal variation in cTnT concentrations is present in patients with chest pain in the emergency department (ED). METHODS: We included all patients with chest pain, but no myocardial infarction (MI), and no other acute condition that may affect troponin concentrations in the ED at Karolinska University Hospital, Stockholm, Sweden, 2011-2014...
February 12, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29447786/high-sensitivity-cardiac-troponin-t-left-ventricular-function-and-outcome-in-non-st-elevation-acute-coronary-syndrome
#2
K M Eggers, T Jernberg, B Lindahl
BACKGROUND: Cardiac troponin (cTn) levels reflect infarct size and depressed left ventricular ejection fraction (LVEF) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). However, there is very limited information on whether cTn measured with a high-sensitivity (hs) assay would provide incremental prognostic information to the LVEF in NSTE-ACS patients. METHODS: This was a registry-based study (SWEDEHEART registry) investigating 20,652 NSTE-ACS patients with available information on hs-cTnT (highest level recorded during the hospitalization) and the LVEF estimated using echocardiography...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29447379/acute-exercise-is-not-cardioprotective-and-may-induce-apoptotic-signalling-in-heart-surgery-a-randomized-controlled-trial
#3
Benedikte T Smenes, Fredrik H Bækkerud, Katrine H Slagsvold, Erlend Hassel, Martin Wohlwend, Maria Pinho, Morten Høydal, Ulrik Wisløff, Øivind Rognmo, Alexander Wahba
OBJECTIVES: During open-heart surgery, the myocardium experiences ischaemia-reperfusion injury. A single bout of moderate, 30-min exercise induces preconditioning and protects the heart from ischaemia-reperfusion injury in rats, but this has never been investigated in humans. We aimed to investigate whether 1 bout of moderate exercise 24 h prior to surgery protects against mitochondrial and cardiac damage. METHODS: Patients scheduled for elective coronary artery bypass were eligible for this pilot study...
February 13, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29445833/functionalized-au-ag-au-nanoparticles-as-an-optical-and-sers-dual-probe-for-lateral-flow-sensing
#4
Tingting Bai, Meng Wang, Min Cao, Juan Zhang, Kangzhen Zhang, Ping Zhou, Zhengxia Liu, Ying Liu, Zhirui Guo, Xiang Lu
Lateral flow assay strips (LFASs) with Au nanoparticles (NPs) have been widely used as a probe for biomarkers in point-of-care testing; however, there still remain challenges in detection sensitivity and quantitative analysis. In this study, we developed a surface-enhanced Raman scattering (SERS)-based LFAS for quantitative analysis of a biomarker in the low concentration range. Moreover, apart from conventional Au NPs, three other types of citrate-capped Au-Ag bimetallic NPs: Au core with Ag shell NPs (Au@Ag NPs), rattle-like Au core in Ag-Au shell NPs (Au@Ag-Au NPs) and Ag-Au NPs were prepared and functionalized, and their solution-based SERS activities were comprehensively studied by experimental measurement and theoretical analysis...
February 14, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29437906/cardiac-troponin-for-predicting-all-cause-mortality-in-patients-with-acute-ischemic-stroke-a-meta-analysis
#5
Yu Fan, Menglin Jiang, Dandan Gong, Changfeng Man, Yuehua Chen
Cardiac troponins are specific biomarkers of cardiac injury. However, the prognostic usefulness of cardiac troponin in patients with acute ischemic stroke is still controversial. The objective of this meta-analysis was to investigate the association of cardiac troponin elevation with all-cause mortality in patients with acute ischemic stroke. PubMed and Embase databases were searched for relevant studies up to April 31, 2017. All observational studies reporting an association of baseline cardiac troponin-T (cTnT) or troponin-I (cTnI) elevation with all-cause mortality risk in patients with acute ischemic stroke were included...
February 5, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29437599/-malignant-left-ventricular-hypertrophy-identifies-subjects-at-high-risk-for-progression-to-asymptomatic-left-ventricular-dysfunction-heart-failure-and-death-mesa-multi-ethnic-study-of-atherosclerosis
#6
Matthew N Peters, Stephen L Seliger, Robert H Christenson, Susie N Hong-Zohlman, Lori B Daniels, Joao A C Lima, James A de Lemos, Ian J Neeland, Christopher R deFilippi
BACKGROUND: As heart failure (HF)-associated morbidity and mortality continue to escalate, enhanced focus on prevention is increasingly important. "Malignant" left ventricular (LV) hypertrophy (LVH): LVH combined with an elevated cardiac biomarker reflecting either injury (high-sensitivity cardiac troponin T), or strain (amino-terminal pro-B-type natriuretic peptide) has predicted accelerated progression to HF. We sought to determine whether malignant LVH identified community-dwelling adults initially free of cardiovascular disease at high risk of asymptomatic decline in LV ejection fraction or a clinical cardiovascular event...
February 8, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29434803/clinical-value-of-cardiac-color-ultrasound-and-cardiac-troponin-t-combined-with-dynamic-electrocardiogram-in-treatment-of-acute-pulmonary-embolism
#7
Hongjun Li, Lixin Kang, Yongqiang Sun
The clinical value of cardiac color ultrasound and cardiac troponin T (cTnT) combined with dynamic electrocardiogram in evaluating the treatment effect on acute pulmonary embolism (APE) was investigated. Ninety-eight patients with APE treated in Jinan Zhangqiu District Hospital of TCM from March 2016 to February 2017 were selected, and they were examined via the cardiac color ultrasound, cTnT and dynamic electrocardiogram to evaluate the clinical value in the treatment of pulmonary embolism. Electrocardiogram showed that there was no significant difference in the poor prognosis rate between right ventricular strain group and non-right ventricular strain group (P>0...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434760/gambogic-acid-exerts-cardioprotective-effects-in-a-rat-model-of-acute-myocardial-infarction-through-inhibition-of-inflammation-inos-and-nf-%C3%AE%C2%BAb-p38-pathway
#8
Duan Na, Hou Aijie, Luan Bo, Miao Zhilin, Yuan Long
Gamboge, the dried resin secreted by Garcinia maingayii (gambogic tree), was previously demonstrated to exert anti-inflammatory effects. The present study examined the effects of gambogic acid, the major active constituent of gamboge, on myocardial infarction (MI) and inflammation in a rat model and explored the possible underlying mechanisms. The results demonstrated that gambogic acid inhibited the ratio of heart weight to body weight and myocardial damage (via lactate dehydrogenase and cardiac troponin T) in rats with MI...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434124/the-usefulness-and-limitations-of-point-of-care-cardiac-troponin-measurement-in-the-emergency-department
#9
Kenichiro Suzuki, Kimiaki Komukai, Kotaro Nakata, Renshi Kan, Yuhei Oi, Eri Muto, Yusuke Kashiwagi, Mitsutoshi Tominaga, Satoru Miyanaga, Tetsuya Ishikawa, Kenji Okuno, Masahiko Uzura, Michihiro Yoshimura
Objective This study was carried out to examine the usefulness of point-of-care (POC) cardiac troponin in diagnosing acute coronary syndrome (ACS) and to understand the limitations of a POC cardiac troponin I/T-based diagnoses. Methods Patients whose cardiac troponin levels were measured in the emergency department using a POC system (AQT System; Radiometer, Tokyo, Japan) between January and December 2016 were retrospectively examined (N=1449). Patients who were < 20 years of age or who were admitted with cardiopulmonary arrest were excluded...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29432376/complementary-diagnostic-value-of-heart-type-fatty-acid-binding-protein-in-early-detection-of-acute-myocardial-infarction
#10
Maryam Sotoudeh Anvari, Mahsa Karimi, Akbar Shafiee, Mohammadali Boroumand, Ali Bozorgi, Reza Sedaghat, Arash Jalali
BACKGROUND: Heart-type fatty acid-binding protein (H-FABP) is a novel biomarker for myocardial injury. We compared the use of H-FABP with serum levels of cardiac troponin-T (cTnT) and creatine kinase-MB (CK-MB) in the diagnosis of patients suspicious to acute myocardial infarction (AMI). METHODS: From October 2013 to December 2014, 182 consecutive patients suspicious to acute coronary syndrome were enrolled in this study, who presented within the past 6 hours from the onset of symptoms...
March 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29432370/experiences-of-a-one-hour-algorithm-in-chest-pain-patients-with-a-nonelevated-troponin-t-at-presentation
#11
Anna Pettersson, Lina Ljung, Caroline Johansson, Umut Heilborn, Tomas Jernberg, Mats Frick, Kai M Eggers, Bertil Lindahl, Rikard Linder, Arne Martinsson, Per Svensson
BACKGROUND: We aimed to evaluate the use of a 1-hour measurement of high-sensitivity cardiac troponin T (hs-cTnT) in an emergency department (ED) population of chest pain patients with a nonelevated baseline hs-cTnT and to examine the prevalence of early dynamic changes in hs-cTnT and the association with admission rate, diagnosis, and outcome. METHODS: All patients with a chief complaint of chest pain presenting to the ED of Karolinska University Hospital, Solna, Sweden, from December 2014 to September 2015 who had a baseline hs-cTnT of ≤14 ng/L and a second value obtained within >30 to ≤90 minutes were followed for 30 days regarding admission, readmission, myocardial infarction (MI), and death...
March 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29430404/spectrum-of-cardiac-manifestations-and-its-relationship-to-outcomes-in-patients-admitted-with-scrub-typhus-infection
#12
Gunasekaran Karthik, Thomas Isaiah Sudarsan, John Victor Peter, Thambu Sudarsanam, George M Varghese, Paul Kundavaram, Sowmya Sathyendra, Ramya Iyyadurai, Kishore Pichamuthu
AIM: To study the spectrum of cardiac manifestations in scrub typhus infection and assess its relationship to outcomes. METHODS: Demographic data, electrocardiographic (ECG) changes, left ventricular (LV) systolic and diastolic function, myocardial injury (defined as troponin T > 14 pg/mL), and pericardial effusion were documented. Myocarditis was diagnosed when myocardial injury was associated with global LV systolic dysfunction. The relationship between myocarditis and outcomes was assessed using logistic regression analysis and expressed as odds ratio (OR) with 95%CI...
February 4, 2018: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29429038/pharmacodynamic-modeling-of-cardiac-biomarkers-in-breast-cancer-patients-treated-with-anthracycline-and-trastuzumab-regimens
#13
Aurelia H M de Vries Schultink, Annelies H Boekhout, Jourik A Gietema, Artur M Burylo, Thomas P C Dorlo, J G Coen van Hasselt, Jan H M Schellens, Alwin D R Huitema
Trastuzumab is associated with cardiotoxicity, manifesting as a decrease of the left-ventricular ejection fraction (LVEF). Administration of anthracyclines prior to trastuzumab increases risk of cardiotoxicity. High-sensitive troponin T and N-terminal-pro-brain natriuretic peptide (NT-proBNP) are molecular markers that may allow earlier detection of drug-induced cardiotoxicity. In this analysis we aimed to quantify the kinetics and exposure-response relationships of LVEF, troponin T and NT-proBNP measurements, in patients receiving anthracycline and trastuzumab...
February 10, 2018: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/29428559/elevated-il-27-in-patients-with-acute-coronary-syndrome-is-associated-with-adverse-ventricular-remodeling-and-increased-risk-of-recurrent-myocardial-infarction-and-cardiovascular-death
#14
Helena Grufman, Troels Yndigegn, Isabel Gonçalves, Jan Nilsson, Alexandru Schiopu
BACKGROUND AND AIMS: IL-27 is an immunoregulatory cytokine belonging to the IL-6/IL-12 family that was found to be elevated in acute coronary syndrome (ACS) patients. We investigated whether IL-27 is related to post-ischemic cardiac remodeling and long-term prognosis in this patient group. METHODS: We included 524 ACS patients, defined as acute myocardial infarction (AMI) or unstable angina (UA). A subgroup of 107 patients donated blood samples 6 weeks after the index event, and underwent a follow-up echocardiographical examination at 1 year...
February 7, 2018: Cytokine
https://www.readbyqxmd.com/read/29414095/cardiac-troponin-t-capture-and-detection-in-real-time-via-epitope-imprinted-polymer-and-optical-biosensing
#15
P Palladino, M Minunni, S Scarano
Millions of premature deaths per year from cardiovascular diseases represent a global threat urging governments to increase global initiatives, as advised by World Health Organization. In particular, together with prevention and management of risk factors, the development of portable platforms for early diagnosis of cardiovascular disorders appears a fundamental task to carry out. Contemporary assays demonstrated very good accuracy for diagnosis of acute myocardial infarction (AMI), but they are based on expensive and fragile capture antibodies...
February 1, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29412738/reciprocity-of-action-of-increasing-oct4-and-repressing-p53-in-transdifferentiation-of-mouse-embryonic-fibroblasts-into-cardiac-myocytes
#16
Hongran Wang, Shuying Zhao, Michelle Barton, Todd Rosengart, Austin J Cooney
p53 is a barrier to somatic cell reprogramming. Deletion or transient suppression of p53 increases the efficiency of reprogramming of somatic cells into induced pluripotent stem cells. Whether p53 represents an obstacle to a similar process transdifferentiation of somatic cells is unknown. However, it is predicted that inhibition of p53 would promote transdifferentiation of fibroblasts into cardiomyocytes. In this study, the effect of p53 on the capacity of cardiogenic transdifferentiation is evaluated using p53 wild-type (p53+/+), p53 heterozygous mutant (p53+/-), and p53 homozygous mutant (p53-/-) mouse embryonic fibroblasts (MEFs)...
February 2018: Cellular Reprogramming
https://www.readbyqxmd.com/read/29407114/objectively-measured-physical-activity-and-cardiac-biomarkers-a-cross-sectional-population-based-study-in-older-men
#17
Tessa J Parsons, Claudio Sartini, Paul Welsh, Naveed Sattar, Sarah Ash, Lucy T Lennon, S Goya Wannamethee, I-Min Lee, Peter H Whincup, Barbara J Jefferis
BACKGROUND: N-terminal pro-brain natriuretic peptide (NT-proBNP) and high sensitivity Troponin T (hsTnT) are markers of cardiac injury used in diagnosis of heart failure and myocardial infarction respectively, and associated with increased risk of cardiovascular disease. Since physical activity is protective against cardiovascular disease and heart failure, we investigated whether higher levels of physical activity, and less sedentary behaviour were associated with lower NT-proBNP and hsTnT...
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29406178/high-sensitivity-cardiac-troponin-t-in-young-healthy-adults-undergoing-non-cardiac-surgery
#18
A Duma, C Wagner, M Titz, M Maleczek, M Hüpfl, V B Weihs, E Samaha, H Herkner, T Szekeres, M Mittlboeck, M G Scott, A S Jaffe, P Nagele
BACKGROUND: It is unclear if isolated postoperative cardiac-troponin elevation, often referred to as myocardial injury, represents a pathological event, as control studies in otherwise healthy adults are lacking. METHODS: In this single-centre prospective observational cohort study, serial high-sensitivity cardiac troponin T (hscTnT) plasma concentrations were obtained from young, healthy adults undergoing elective orthopaedic surgery at three time points: before operation, 2-6 h, and 18-30 h after surgery...
February 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29403612/evaluation-of-cardiac-functions-in-children-with-duchenne-muscular-dystrophy-a-prospective-case-control-study
#19
Abdelrahim Abdrabou Sadek, Shaimaa Mohamed Mahmoud, Mohammed Abd El-Aal, Ahmed Ahmed Allam, Walaa Ibrahim Abd El-Halim
Background: Duchenne muscular dystrophy (DMD) is the most common childhood form of muscular dystrophy. The incidence of cardiomyopathy in DMD increases with age, so its early detection is important because institution of cardioprotective medical therapies may slow adverse remodeling and attenuate heart failure symptoms in these patients. Objective: To assess the cardiac functions in children clinically suspected to have DMD. Methods: Over a one-year period, 28 male children aged from 3 to 18 years old, who met the criteria for diagnosis of DMD compared to 47 healthy controls children, were approached to participate in the study...
November 2017: Electronic Physician
https://www.readbyqxmd.com/read/29402414/camkii-mediated-phosphorylation-of-ryr2-plays-a-crucial-role-in-aberrant-ca2-release-as-an-arrhythmogenic-substrate-in-cardiac-troponin-t-related-familial-hypertrophic-cardiomyopathy
#20
Shinichi Okuda, Yoko Sufu-Shimizu, Takayoshi Kato, Masakazu Fukuda, Shigehiko Nishimura, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, Sachio Morimoto, Masafumi Yano
AIMS: Cardiac Troponin T (TnT) mutation-linked familial hypertrophic cardiomyopathy (FHC) is known to cause sudden cardiac death at a young age. Here, we investigated the role of the Ca2+ release channel of the cardiac sarcoplasmic reticulum (SR), ryanodine receptor (RyR2), in the pathogenic mechanism of lethal arrhythmia in FHC-related TnT-mutated transgenic mice (TG; TnT-delta160E). METHODS AND RESULTS: In TG cardiomyocytes, the Ca2+ spark frequency (SpF) was much higher than that in non-TG cardiomyocytes...
January 31, 2018: Biochemical and Biophysical Research Communications
keyword
keyword
104395
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"