Abby Olsen, Joseph Locascio, Idil Tuncali, Nada Laroussi, Elena Abatzis, Polina Kamenskaya, Yuliya Kuras, Tom Yi, Aleks Videnovic, Michael Hayes, Gary Ho, Jordan Paulson, Vikram Khurana, Todd Herrington, Bradley Hyman, Dennis Selkoe, John Growdon, Stephen Gomperts, Trond Riise, Michael Schwarzschild, Albert Hung, Anne Wills, Clemens Scherzer
BACKGROUND: Associations between phenotypic traits, environmental exposures, and Parkinson's disease have largely been evaluated one-by-one, piecemeal, and pre-selections. A comprehensive picture of comorbidities, phenotypes, exposures, and polypharmacy characterizing the complexity and heterogeneity of real-world patients presenting to academic movement disorders clinics in the US is missing. OBJECTIVES: To portrait the complexity of features associated with patients with Parkinson's disease in a study of 933 cases and 291 controls enrolled in the Harvard Biomarkers Study...
December 22, 2023: Research Square