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Marcela Martínez Bascuñán, Carolina Rojas Quezada
Accessibility models in transport geography based on geographic information systems have proven to be an effective method in determining spatial inequalities associated with public health. This work aims to model the spatial accessibility from populated areas within the Concepción metropolitan area (CMA), the second largest city in Chile. The city's public hospital network is taken into consideration with special reference to socio-regional inequalities. The use of geographically weighted regression (GWR) and ordinary least squares (OLS) for modelling accessibility with socioeconomic and transport variables is proposed...
November 22, 2016: Geospatial Health
Concepcion Perez-Jorge, Maria-Angeles Arenas, Ana Conde, Juan-Manuel Hernández-Lopez, Juan-Jose de Damborenea, Steve Fisher, Alessandra M Agostinho Hunt, Jaime Esteban, Garth James
Orthopaedic device-related infections are closely linked to biofilm formation on the surfaces of these devices. Several modified titanium (Ti-6Al-4V) surfaces doped with fluorine were studied in order to evaluate the influence of these modifications on biofilm formation by Gram-positive and Gram-negative bacteria as well as a yeast. The biofilm studies were performed according to the standard test method approved by ASTM (Designation: E2196-12) using the Rotating Disk Reactor. Four types of Ti-6Al-4V samples were tested; chemically polished (CP), two types of nanostructures containing fluorine, nanoporous (NP) and nanotubular (NT), and non-nanostructured fluorine containing samples (fluoride barrier layers, FBL)...
January 2017: Journal of Materials Science. Materials in Medicine
Diego Rivera, Alonso Verde, Concepción Obón, Francisco Alcaraz, Candelaria Moreno, Teresa Egea, José Fajardo, José Antonio Palazón, Arturo Valdés, Maria Adele Signorini, Piero Bruschi
ETHNOPHARMACOLOGICAL RELEVANCE: This paper has two overarching aims: (1) presenting the results of studying the Albacete tariff of medicines of 1526 and (2) broadly analyzing the origin and influences of medicinal traditional knowledge in the region of Albacete, Spain. We use historical and modern literature that may have influenced this knowledge. Our primary goal was to determine the ingredients used in the pharmacy in the 16th century CE in Albacete through the analysis of the tariff, and our secondary goal was to investigate until when ingredients and uses present in pharmacy and herbals persisted in later periods...
November 25, 2016: Journal of Ethnopharmacology
Irene Cañamares Orbis, Javier Saez de la Fuente, Ismael Escobar Rodriguez, Concepción Esteban Alba, Ana Such Díaz, Ismael Escobar Rodríguez
BACKGROUND AND OBJECTIVE: To learn about and analyze the self-reported treatment experience of HCV patients who started treatment with direct acting antivirals agents (DAA), at a real-time, proactive and integrated into the pharmaceutical care healthcare process, using a prospective questionnaire completed by patients as clinical tool. MATERIAL AND METHODS: Observational and cross-sectional study conducted between April (start of the National Strategic Plan) and December 2015 in the Outpatient Pharmacy Service...
November 1, 2016: Farmacia Hospitalaria
María Fernández-Marcos, Bénédicte Desvoyes, Concepción Manzano, Louisa M Liberman, Philip N Benfey, Juan C Del Pozo, Crisanto Gutierrez
Root branching in plants relies on the de novo formation of lateral roots. These are initiated from founder cells, triggering new formative divisions that generate lateral root primordia (LRP). The LRP size and shape depends on the balance between positive and negative signals that control cell proliferation. The mechanisms controlling proliferation potential of LRP cells remains poorly understood. We found that Arabidopsis thaliana MYB36, which have been previously shown to regulate genes required for Casparian strip formation and the transition from proliferation to differentiation in the primary root, plays a new role in controlling LRP development at later stages...
January 2017: New Phytologist
María Remedios Sánchez-García, Marina Moreno-Rodríguez, César Hueso-Montoro, Concepción Campos-Calderón, Ana Varella-Safont, Rafael Montoya-Juárez
AIM: To identify the facilitators and barriers experienced by professional related to end of life care in nursing homes. DESIGN: Descriptive qualitative research with phenomenological orientation, through content analysis. PLACEMENT: Nursing Homes at Primary Care District in Granada (Spain). PARTICIPANTS: Fifteen clinical professionals with, at least 6 months of experience in nursing homes, without specific background in palliative care...
November 24, 2016: Atencion Primaria
Macario Osorio-Concepción, Gema Rosa Cristóbal Mondragón, Braulio Gutiérrez-Medina, Sergio Casas-Flores
: Fungal blue-light photoreceptors have been proposed as integrators of light and oxidative stress. However, additional elements participating in the integrative pathway remain to be identified. In Trichoderma atroviride, the blue-light receptor proteins BLR-1 and -2 are known to regulate gene transcription, mycelial growth and asexual development upon illumination, and recent global transcriptional analysis revealed that the histone deacetylase encoding gene hda-2 is induced by light...
November 18, 2016: Applied and Environmental Microbiology
Sara Salehi Hammerstad, Mihaela Stefan, Jason Blackard, Randall P Owen, Hanna J Lee, Erlinda Concepcion, Zhengzi Yi, Weijia Zhang, Yaron Tomer
CONTEXT: Thyroiditis is one of the most common extra hepatic manifestations of hepatitis C virus infection. By binding to surface cell receptor CD81, hepatitis C envelop glycoprotein E2 mediates entry of HCV into cells. Studies have shown that different viral proteins may individually induce host responses to infection. We hypothesized that HCV E2 protein binding to CD81 expressed on thyroid cells activates a cascade of inflammatory responses that can trigger autoimmune thyroiditis in susceptible individuals...
November 18, 2016: Journal of Clinical Endocrinology and Metabolism
Avelino Corma, Juan Diego Vidal, Maria Jose Climent, Patricia Concepcion, Sara Iborra
N-substituted-5-methyl-2-pyrrolidones have been prepared in one pot process starting from ethyl levulinate and nitro compounds and in the presence of nanosized platinum based catalyst. Pt supported on TiO2 nanotubes (Pt/TiO2-NT) catalyzes the synthesis of N-substituted-5-methyl-2-pyrrolidones through a cascade process which involves the reduction of nitro compounds, formation of the intermediary imine, hydrogenation and subsequent cyclization. A bifunctional metal-acid system works for the process. Pt on TiO2 gives lower catalytic activity than Pt/TiO2-NT due to the strong adsorption of nitro compounds during the first reaction step that poisons the acidic sites and strongly decreases the rate of amination and cyclization steps...
November 8, 2016: ChemSusChem
Javier Cañueto, Ester Cardeñoso-Álvarez, Adriana Cosano-Quero, Ángel Santos-Briz, Emilia Fernández-López, Jesús Pérez-Losada, Concepción Román-Curto
BACKGROUND: Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and can be both locally invasive and metastatic at distant sites. While research efforts have been made to predict poor outcome of CSCC, there is a lack of knowledge regarding molecular markers. PODOPLANIN has been associated with poor outcome in several types of cancer including CSCC, but this is controversial and only a few studies have evaluated the prognostic implications of Podoplanin in the development of this tumor...
November 10, 2016: Journal of Cutaneous Pathology
Keiichiro Suzuki, Yuji Tsunekawa, Reyna Hernandez-Benitez, Jun Wu, Jie Zhu, Euiseok J Kim, Fumiyuki Hatanaka, Mako Yamamoto, Toshikazu Araoka, Zhe Li, Masakazu Kurita, Tomoaki Hishida, Mo Li, Emi Aizawa, Shicheng Guo, Song Chen, April Goebl, Rupa Devi Soligalla, Jing Qu, Tingshuai Jiang, Xin Fu, Maryam Jafari, Concepcion Rodriguez Esteban, W Travis Berggren, Jeronimo Lajara, Estrella Nuñez-Delicado, Pedro Guillen, Josep M Campistol, Fumio Matsuzaki, Guang-Hui Liu, Pierre Magistretti, Kun Zhang, Edward M Callaway, Kang Zhang, Juan Carlos Izpisua Belmonte
Targeted genome editing via engineered nucleases is an exciting area of biomedical research and holds potential for clinical applications. Despite rapid advances in the field, in vivo targeted transgene integration is still infeasible because current tools are inefficient, especially for non-dividing cells, which compose most adult tissues. This poses a barrier for uncovering fundamental biological principles and developing treatments for a broad range of genetic disorders. Based on clustered regularly interspaced short palindromic repeat/Cas9 (CRISPR/Cas9) technology, here we devise a homology-independent targeted integration (HITI) strategy, which allows for robust DNA knock-in in both dividing and non-dividing cells in vitro and, more importantly, in vivo (for example, in neurons of postnatal mammals)...
December 1, 2016: Nature
Claude Robert, Concepción S Wilson, Richard B Lipton, Charles-Daniel Arreto
AIM: This study charts the growth of the scientific journal literature on headache for 30+ years (1983-2014). METHODS: Using the Web of Science, articles published in four two-year periods (1983-1984, 1993-1994, 2003-2004, 2013-2014) from journals indexed in the Science Citation Index Expanded database were retrieved and analyzed. RESULTS: From 1983-1984 to 2013-2014, the scientific literature on headache increased nearly fourfold (3.8) from 468 to 1776 articles; the number of participating countries more than doubled (26 to 67); and the two most prolific countries in each period were the USA and Italy...
November 11, 2016: Cephalalgia: An International Journal of Headache
Erika Rodríguez-Martínez, Concepcion Nava-Ruiz, Elsa Escamilla-Chimal, Gabino Borgonio-Perez, Selva Rivas-Arancibia
The chronic exposure to low doses of ozone, like in environmental pollution, leads to a state of oxidative stress, which has been proposed to contribute to neurodegenerative disorders, including Alzheimer's disease (AD). It induces an increase of calcium in the endoplasmic reticulum (ER), which produces ER stress. On the other hand, different studies show that, in diseases such as Alzheimer's, there exist disturbances in protein folding where ER plays an important role. The objective of this study was to evaluate the state of chronic oxidative stress on ER stress and its relationship with apoptotic death in the hippocampus of rats exposed to low doses of ozone...
2016: Frontiers in Aging Neuroscience
Domingo Orozco-Beltrán, Eva Sánchez, Alejandro Garrido, José Antonio Quesada, M Concepción Carratalá-Munuera, Vicente F Gil-Guillén
INTRODUCTION AND OBJECTIVES: Diabetes mellitus (DM) is a leading causes of death, mainly due to cardiovascular complications. The aim of this study was to describe DM mortality in Spain from 1998 to 2013 and to compare it between distinct provinces. METHODS: Ecological time-trend study. Data sources consisted of the population register and the death rate figures, by cause of death, from Spain's National Statistics Institute. Rates were age-standardized by the direct method...
November 4, 2016: Revista Española de Cardiología
Irene Gavilanes-Terán, Janneth Jara-Samaniego, Julio Idrovo-Novillo, Ma Angeles Bustamante, Ma Dolores Pérez-Murcia, Aurelia Pérez-Espinosa, Marga López, Concepción Paredes
This work was conducted in order to investigate the possibility of using different agroindustrial composts in the production of horticultural seedlings, thereby replacing part of the peat in the growing media. Three vegetable species differing in salt sensitivity - tomato (Solanum lycopersicum L. var. Malpica) (the least sensitive), courgette (Cucurbita pepo L. var. Mastil F1) (moderately sensitive) and pepper (Capsicum annuum L. var. Largo de Reus Pairal) (the most sensitive) - were grown in nine media containing three composts, prepared by co-composting vegetable waste (flower, broccoli or tomato waste) with laying hen manure and sawdust, as well as peat in various ratios...
November 1, 2016: Journal of Environmental Management
Dahyann Araya-Muñoz, Marc J Metzger, Neil Stuart, A Meriwether W Wilson, Danilo Carvajal
Even though most cities are exposed to more than one hazard, local planners and decision-makers still have a limited understanding of the exposure and sensitivity to and the spatial distribution of hazards. We examine the impact of multiple hazards in the Concepción Metropolitan Area (CMA), Chile. A flexible methodology based on spatial fuzzy logic modelling was developed to explore the impact of weather-related hazards, including coastal flooding, fluvial flooding, water scarcity, heat stress, and wildfire...
October 27, 2016: Science of the Total Environment
Javier Escalada, Domingo Orozco-Beltran, Carlos Morillas, Fernando Alvarez-Guisasola, Fernando Gomez-Peralta, Manel Mata-Cases, Rafael Palomares, Rosario Iglesias, Concepción Carratalá-Munuera
AIMS: To describe the views of healthcare providers about starting insulin in patients with type 2 diabetes and to determine the specific factors that contribute to delay insulin initiation. METHODS: Two-phases observational descriptive study. In the quantitative phase we conducted a cross-sectional survey of a sample of 380 healthcare professionals (general practitioners (GPs), endocrinologists, internists and nurses). In the qualitative phase, a discussion group reviewed the results of the survey to propose solutions...
October 14, 2016: Diabetes Research and Clinical Practice
Concepción Violán, Néker Bejarano-Rivera, Quintí Foguet-Boreu, Albert Roso Llorach, Mariona Pons-Vigués, Miguel Martin Mateo, Enriqueta Pujol-Ribera
BACKGROUND: Cardiovascular diseases are highly represented in multimorbidity patterns. Nevertheless, few studies have analysed the burden of these diseases in the population with multimorbidity. The objective of this study was to identify and describe the cardiovascular diseases among the patients with multimorbidity. METHODS: We designed a cross-sectional study in patients ≥19 years old assigned to 251 primary health care centres in Catalonia, Spain. The main outcome was cardiovascular morbidity burden, defined as the presence of one or more of 24 chronic cardiovascular diseases in multimorbid patients (≥2 chronic conditions)...
November 3, 2016: BMC Family Practice
Javier Troyano, Josefina Perles, Pilar Amo-Ochoa, Jose Ignacio Martínez, Maria Concepción Gimeno, Vanesa Fernández-Moreira, Félix Zamora, Salomé Delgado
Solvothermal reactions between copper(I) halides and 4-mercaptophenol give rise to the formation of three coordination polymers with general formula [Cu3 X(HT)2 ]n (X=Cl, 1; Br, 2; and I, 3). The structures of these coordination polymers have been determined by X-ray diffraction at both room- and low temperature (110 K), showing a general shortening in Cu-S, Cu-X and Cu-Cu bond lengths at low temperatures. 1 and 2 are isostructural, consisting of layers in which the halogen ligands act as μ3 -bridges joining two Cu1 and one Cu2 atoms whereas in 3 the iodine ligands is as μ4 -mode but the layers are quasi-isostructural with 1 or 2...
November 3, 2016: Chemistry: a European Journal
Concepción Padilla, Julia Mayas, Soledad Ballesteros, Pilar Andrés
Despite the evidence revealing benefits of chronic cardiovascular exercise on executive functions, little research has been conducted on long-term memory. We aimed to investigate the effect of physical exercise on implicit and explicit memory when attention was modulated at encoding in two groups of active and sedentary participants. With this purpose, attention was manipulated in a similar way in the implicit and explicit memory tasks by presenting picture outlines of two familiar objects, one in blue and the other in green, and participants were asked to pay attention only to one of them...
November 2, 2016: Memory
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