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https://www.readbyqxmd.com/read/29778695/corticosteroids-and-perinatal-hypoxic-ischemic-brain-injury
#1
REVIEW
Katherine R Concepcion, Lubo Zhang
Perinatal hypoxic-ischemic (HI) brain injury is the major cause of neonatal mortality and severe long-term neurological morbidity. Yet, the effective therapeutic interventions currently available are extremely limited. Corticosteroids act on both mineralocorticoid (MR) and glucocorticoid (GR) receptors and modulate inflammation and apoptosis in the brain. Neuroinflammatory response to acute cerebral HI is a major contributor to the pathophysiology of perinatal brain injury. Here, we give an overview of current knowledge of corticosteroid-mediated modulations of inflammation and apoptosis in the neonatal brain, focusing on key regulatory cells of the innate and adaptive immune response...
May 17, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29778184/interaction-of-prrs-virus-with-bone-marrow-monocyte-subsets
#2
Teresa Fernández-Caballero, Belén Álvarez, Fernando Alonso, Concepción Revilla, Javier Martínez-Lobo, Cinta Prieto, Ángel Ezquerra, Javier Domínguez
PRRSV can replicate for months in lymphoid organs leading to persistent host infections. Porcine bone marrow comprises two major monocyte subsets, one of which expresses CD163 and CD169, two receptors involved in the entry of PRRSV in macrophages. In this study, we investigate the permissiveness of these subsets to PRRSV infection. PRRSV replicates efficiently in BM CD163+ monocytes reaching titers similar to those obtained in alveolar macrophages, but with a delayed kinetics. Infection of BM CD163- monocytes was variable and yielded lower titers...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29774836/pulmonary-infections-with-nontuberculous-mycobacteria-catalonia-spain-1994-2014
#3
Miguel Santin, Irene Barrabeig, Pierre Malchair, Lucia Gonzalez-Luquero, Miguel A Benitez, Josefina Sabria, Merce Palau-Benavent, Concepcion Cañete, Joan A Lloret-Queraltó, Maria D Grijota-Camino, Jordi Dorca, Fernando Alcaide
In Spain, systematic reporting of pulmonary infections with nontuberculous mycobacteria is not mandatory. Therefore, to determine trends, we retrospectively identified cases for January 1994-December 2014 in Catalonia. Over the 21 years, prevalence increased and was associated with being male. Mycobacterium avium complex and M. abscessus prevalence increased; M. kansasii prevalence decreased.
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29770691/digestibility-of-poly-phenols-and-antioxidant-activity-in-raw-and-cooked-cactus-cladodes-opuntia-ficus-indica
#4
Elsy De Santiago, Gema Pereira Caro, Jose-Manuel Moreno Rojas, Concepcion Cid, M Paz De Peña
This study aims to investigate whether heat treatment applied to cactus cladodes influences on the bioaccessibility of their (poly)phenolic compounds after simulated gastric and intestinal digestion. A total of 45 (poly)phenols were identified and quantified in raw and cooked cactus cladodes by UHPLC-PDA-HR-MS. Both flavonoids (60-68% total), mainly isorhamnetin derivatives, and phenolic acids (32-40%) with eucomic acids as the predominant ones, significantly (p<0.05) increased with microwaving and griddling processes...
May 17, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29767194/qm-mm-simulations-identify-the-determinants-of-catalytic-activity-differences-between-type-ii-dehydroquinase-enzymes
#5
Emilio Lence, Marc W van der Kamp, Concepción González-Bello, Adrian J Mulholland
Type II dehydroquinase enzymes (DHQ2), recognized targets for antibiotic drug discovery, show significantly different activities dependent on the species: DHQ2 from Mycobacterium tuberculosis (MtDHQ2) and Helicobacter pylori (HpDHQ2) show a 50-fold difference in catalytic efficiency. Revealing the determinants of this activity difference is important for our understanding of biological catalysis and further offers the potential to contribute to tailoring specificity in drug design. Molecular dynamics simulations using a quantum mechanics/molecular mechanics potential, with correlated ab initio single point corrections, identify and quantify the subtle determinants of the experimentally observed difference in efficiency...
May 16, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29763781/inhibition-of-vegf-gene-expression-in-osteoblast-cells-by-different-nsaids
#6
Francisco Javier Manzano-Moreno, Victor Javier Costela-Ruiz, Lucía Melguizo-Rodríguez, Rebeca Illescas-Montes, Olga García-Martínez, Concepción Ruiz, Javier Ramos-Torrecillas
OBJECTIVE: To determine the effect of different nonsteroidal anti-inflammatory drugs (NSAIDs) on vascular endothelial growth factor (VEGF) gene expression in two osteoblast cell populations. DESIGN: Osteoblasts obtained by primary culture (HOp) and human osteosarcoma cell line MG63 (MG-63), which were treated with 10 μM doses of acetaminophen, indomethacin, ketoprofen, diclofenac, ibuprofen, ketorolac, naproxen or piroxicam. At 24 h of treatment, their gene expression of VEGF was evaluated by real-time polymerase chain reaction (RT-PCR) and compared with the expression in untreated cells (control group)...
May 9, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29751214/a-study-of-the-properties-reactivity-and-anticancer-activity-of-novel-n-methylated-3-thiazolyl-or-3-thienyl-carbazoles-and-their-pd-ii-and-pt-ii-complexes
#7
Marta Reig, Ramón Bosque, Mercè Font-Bardía, Carme Calvis, Ramon Messeguer, Laura Baldomà, Josefa Badía, Dolores Velasco, Concepción López
No abstract text is available yet for this article.
March 15, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29750791/impact-of-benznidazole-treatment-on-the-functional-response-of-trypanosoma-cruzi-antigen-specific-cd4-cd8-t-cells-in-chronic-chagas-disease-patients
#8
Elena Pérez-Antón, Adriana Egui, M Carmen Thomas, Concepción J Puerta, John Mario González, Adriana Cuéllar, Manuel Segovia, Manuel Carlos López
BACKGROUND: Chagas disease is caused by Trypanosoma cruzi. The persistence of the parasite is associated with the disease chronicity and the impairment of the cellular immune response. It has been reported that the CD4+CD8+ T cell population expands in chronic Chagas disease patients. Few studies have focused on this subset of cells, and very little is known about the impact of antiparasitic treatment on this population. METHODOLOGY: Thirty-eight chronic Chagas disease patients (20 asymptomatic and 18 symptomatic) and twelve healthy controls were enrolled in this study...
May 11, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29747579/burnout-syndrome-and-its-prevalence-in-primary-care-nursing-a-systematic-review-and-meta-analysis
#9
Carolina S Monsalve-Reyes, Concepción San Luis-Costas, Jose L Gómez-Urquiza, Luis Albendín-García, Raimundo Aguayo, Guillermo A Cañadas-De la Fuente
BACKGROUND: burnout syndrome is a significant problem in nursing professionals. Although, the unit where nurses work may influence burnout development. Nurses that work in primary care units may be at higher risk of burnout. The aim of the study was to estimate the prevalence of emotional exhaustion, depersonalization and low personal accomplishment in primary care nurses. METHODS: We performed a meta-analysis. We searched Pubmed, CINAHL, Scopus, Scielo, Proquest, CUIDEN and LILACS databases up to September 2017 to identify cross-sectional studies assessing primary care nurses' burnout with the Maslach Burnout Inventory were included...
May 10, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29745885/explorative-analyses-of-protein-biomarkers-in-patients-with-early-rheumatoid-arthritis-achieving-sustained-drug-free-remission-after-treatment-with-tocilizumab-or-methotrexate-based-strategies-from-transcriptomics-to-proteomics
#10
Xavier M Teitsma, Johannes W G Jacobs, Arno N Concepcion, Attila Pethö-Schramm, Michelle E A Borm, Jacob M van Laar, Johannes W J Bijlsma, Floris P J G Lafeber
OBJECTIVES: Previously, we identified networks of co-expressed genes related to achieving sustained drug-free remission (sDFR). The aim of the present exploratory analysis was to identify inflammatory proteins associated with achieving sDFR and their enriched biological pathways, and compare these pathways with those found in the previous transcriptomic analyses. METHODS: Serum samples were used from 60 patients who participated in the U-Act-Early trial and were treated-to-target with tocilizumab plus methotrexate, or tocilizumab or methotrexate; 37 achieved sDFR (≥3 months drug-free) and 23 did not (controls)...
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29743809/evaluation-of-regulatory-immune-response-in-skin-lesions-of-patients-affected-by-nonulcerated-or-atypical-cutaneous-leishmaniasis-in-honduras-central-america
#11
Gabriela Venicia Araujo Flores, Carmen Maria Sandoval Pacheco, Thaise Yumie Tomokane, Wilfredo Sosa Ochoa, Concepción Zúniga Valeriano, Claudia Maria Castro Gomes, Carlos Eduardo Pereira Corbett, Marcia Dalastra Laurenti
In Honduras, Leishmania (L.) infantum chagasi causes both visceral leishmaniasis (LV) and nonulcerated or atypical cutaneous leishmaniasis (NUCL). NUCL is characterized by mononuclear inflammatory infiltration of the dermis, composed mainly of lymphocytes followed by macrophages with discrete parasitism. Considering that little is known about the pathogenesis of NUCL, the aim of this study was to evaluate the regulatory response in situ in skin lesions of patients affected by NUCL. Biopsies ( n = 20) from human cutaneous nonulcerative lesions were collected and processed by usual histological techniques...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29739067/fasting-glycemia-as-screening-tool-to-rule-out-gestational-diabetes-in-low-risk-population
#12
Jose-Maria Maesa, Patricia Fernandez-Riejos, Victor Sanchez-Margalet, Concepcion Gonzalez-Rodriguez
BACKGROUND: The use of a glucose challenge test as the universal screening for gestational diabetes is common in many countries. This test represents significant costs for laboratories and inconveniences for the patients, who have to wait for one hour and, very often, feel discomfort and nausea. In this work we propose the use of fasting glycemia, in a population with low prevalence of gestational diabetes as a pre-screening test that would avoid the oral glucose overload in those pregnant women with low risk of gestational diabetes...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29736745/activation-of-the-cannabinoid-type-2-receptor-by-a-novel-indazole-derivative-normalizes-the-survival-pattern-of-lymphoblasts-from-patients-with-late-onset-alzheimer-s-disease
#13
Patricia Del Cerro, Carolina Alquézar, Fernando Bartolomé, Pedro González-Naranjo, Concepción Pérez, Eva Carro, Juan A Páez, Nuria E Campillo, Ángeles Martín-Requero
BACKGROUND: Alzheimer's disease is a multifactorial disorder for which there is no disease-modifying treatment yet. CB2 receptors have emerged as a promising therapeutic target for Alzheimer's disease because they are expressed in neuronal and glial cells and their activation has no psychoactive effects. OBJECTIVE: The aim of this study was to investigate whether activation of the CB2 receptor would restore the aberrant enhanced proliferative activity characteristic of immortalized lymphocytes from patients with late-onset Alzheimer's disease...
May 7, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29733059/citotoxicidad-de-soluciones-recomendadas-para-el-almacenamiento-de-dientes-avulsionados-en-cultivo-con-c%C3%A3-lulas-del-ligamento-periodontal
#14
Galia Cruz-Durán, Raúl Ortiz-Daza Raúl, Jacinto Armando Díaz-Acevedo, Benjamín Sánchez-Trocino, Ma Concepción Arenas-Arrocena, René García-Contreras
Introducción: El medio de almacenamiento de los dientes avulsionados hasta su reimplante es vital para conservar los fibroblastos del ligamento periodontal humano (HPLF). Objetivo: Comparar el efecto citotóxico para conservar los HPLF de la leche y la solución isotónica para almacenamiento de dientes avulsionados. Método: Se realizó subcultivo de fibroblastos del ligamento periodontal con una densidad de 1:2 (3 × 105 células/mL), que fueron incubados por 48 horas...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29731180/validation-of-the-electronic-prescription-as-a-method-for-measuring-treatment-adherence-in-hypertension
#15
Emilio Márquez-Contreras, Lourdes de López García-Ramos, Nieves Martell-Claros, Vicente F Gil-Guillen, Sara Márquez-Rivero, Elena Pérez-López, Maria Angeles Garrido-Lopez, Celia Farauste, Adriana López-Pineda, José Joaquin Casado-Martinez, Domingo Orozco-Beltran, Jose A Quesada, Concepción Carratalá-Munuera
OBJECTIVE: To validate electronic prescriptions (e-prescriptions) as a method for measuring treatment adherence in patients with hypertension. METHODS: This prospective study initially included 120 patients treated for hypertension in primary care centers. Adherence was measured using the gold standard, the medication event monitoring system (MEMS), versus the index test, the e-prescription program, at baseline and at 6, 12, 18 and 24 months. We calculated the adherence rate using the MEMS and the medication possession ratio (MPR) for the e-prescriptions...
April 23, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/29726087/asthma-and-allergic-rhinitis-associate-with-the-rs2229542-variant-that-induces-a-p-lys90glu-mutation-and-compromises-akr1b1-protein-levels
#16
Elena García-Martín, Francisco J Sánchez-Gómez, Gemma Amo, Jesús García Menaya, Concepción Cordobés, Pedro Ayuso, M Carmen Plaza Serón, Miguel Blanca, Paloma Campo, Gara Esguevillas, María A Pajares, José A G Agúndez, Dolores Pérez-Sala
Asthma and rhinitis are two of the main clinical manifestations of allergy, in which increased reactive oxygen or electrophilic species can play a pathogenic role. Aldose reductase (AKR1B1) is involved in aldehyde detoxification and redox balance. Recent evidence from animal models points to a role of AKR1B1 in asthma and rhinitis, but its involvement in human allergy has not been addressed. Here, the putative association of allergic rhinitis and asthma with AKR1B1 variants has been explored by analysis of single-strand variants on the AKR1B1 gene sequence in 526 healthy subjects and 515 patients with allergic rhinitis, 366 of whom also had asthma...
May 3, 2018: Human Mutation
https://www.readbyqxmd.com/read/29722474/identification-of-the-critical-isthmus-of-a-reentrant-ventricular-tachycardia-at-a-glance
#17
Concepción Alonso-Martín, Enrique Rodríguez, José M Guerra, Xavier Viñolas
No abstract text is available yet for this article.
May 3, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29722267/recommendations-to-report-and-interpret-hla-genetic-findings-in-coeliac-disease
#18
Concepción Núñez, José Antonio Garrote, Eduardo Arranz, José Ramón Bilbao, Fernando Fernández Bañares, Juana Jiménez, Teresa Perucho, Eva Ruiz Casares, Félix Sánchez-Valverde, Nacho Serrano
Coeliac disease (CD) is a chronic autoimmune enteropathy triggered by gluten and related prolamines in genetically predisposed individuals. Although CD is a polygenic disease, there is a strong association with genes of the human leukocyte antigen (HLA) region. Most patients present the HLA-DQ2 heterodimer, specifically the DQ2.5 isoform, which is present in around 90-96% of patients of European ancestry.
May 3, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29721765/a-survey-of-perceptions-attitudes-knowledge-and-practices-of-medical-oncologists-about-cancer-pain-management-in-spain
#19
Jesús García-Mata, Cecilio Álamo, Javier de Castro, Jorge Contreras, Rafael Gálvez, Carlos Jara, Antonio Llombart, Concepción Pérez, Pedro Sánchez, Susana Traseira, Juan-Jesús Cruz
PURPOSE: To monitor oncologists' perspective on cancer pain management. METHODS: An anonymized survey was conducted in two waves. First, over a convenience sample of oncologists known to be particularly concerned with the management of pain. Second, using a random sample of oncologists. RESULTS: In total, 73 and 82 oncologists participated in the first and second wave, respectively. Many oncologists reported to have good knowledge of analgesic drugs (95...
May 2, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29709013/prevalence-of-and-risk-factors-for-low-bone-mineral-density-in-spanish-treated-hiv-infected-patients
#20
Miguel Cervero, Rafael Torres, Jose Luís Agud, Victoria Alcázar, Juan José Jusdado, Concepción García-Lacalle, Santiago Moreno
OBJECTIVES: Several studies have involved antiretroviral therapy in the pathogenesis of low bone mineral density (BMD), while others have not confirmed this association. In this study we analyze the impact of HIV status, traditional risk factors and antiretroviral therapy in BMD in an HIV-infected population living in Madrid. MATERIAL AND METHODS: We performed a cross-sectional analysis of 107 individuals infected with HIV and exposed to antiretroviral treatment to estimate the prevalence of decreased BMD...
2018: PloS One
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