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https://www.readbyqxmd.com/read/28339474/a-decrease-in-intact-parathyroid-hormone-ipth-levels-is-associated-with-higher-mortality-in-prevalent-hemodialysis-patients
#1
Ricardo Villa-Bellosta, Laura Rodriguez-Osorio, Sebastian Mas, Younes Abadi, Mercedes Rubert, Concepción de la Piedra, Carolina Gracia-Iguacel, Ignacio Mahillo, Alberto Ortiz, Jesús Egido, Emilio González-Parra
BACKGROUND: The mortality of dialysis patients is 10- to 100-fold higher than in the general population. Baseline serum PTH levels, and more recently, changes in serum PTH levels (ΔPTH) over time, have been associated to mortality in dialysis patients. METHODS: We explored the relationship between ΔPTH over 1 year with mortality over the next year in a prospective cohort of 115 prevalent hemodialysis patients from a single center that had median baseline iPTH levels within guideline recommendations...
2017: PloS One
https://www.readbyqxmd.com/read/28336266/progesterone-and-estradiol-profiles-in-different-reproductive-stages-of-captive-collared-peccary-pecari-tajacu-females-assessed-by-fecal-metabolites
#2
Concepción Ahuja-Aguirre, Lorena López-deBuen, Susana Rojas-Maya, Bertha C Hernández-Cruz
The study determined the fecal progesterone and estradiol profiles in different reproductive stages of captive collared peccary (Pecari tajacu) females from eastern Mexico. Fifteen adult females were included. At the start of the study the females were either pregnant (early, mid, or late pregnancy), lactating, or non-lactating of unknown pregnancy status. Feces from each female were collected once a week during nine consecutive months to determine concentrations of fecal progesterone and estradiol metabolites using ELISA...
March 18, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28327792/vegetation-loss-and-the-2016-oropouche-fever-outbreak-in-peru
#3
Daniel Romero-Alvarez, Luis E Escobar
BACKGROUND: Oropouche virus causes Oropouche fever, an arboviral disease transmitted mainly by midges of the genus Culicoides and Culex mosquitoes. Clinical presentation of Oropouche fever in humans includes fever, headache, rash, myalgia, and in rare cases spontaneous bleeding and aseptic meningitis. Landscape change has been proposed as a driver of Oropouche fever emergence. OBJECTIVE: To investigate the landscape epidemiology of the Oropouche fever outbreak that began in April 2016 in Cusco, Peru...
April 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28323636/ultrasmall-water-dispersible-tween80-modified-yb-er-nagd-wo-sub-4-sub-sub-2-sub-nanoparticles-with-record-upconversion-ratiometric-thermal-sensitivity-and-their-internalization-by-mesenchymal-stem-cells
#4
Concepcion Cascales, Carlos Paino, Eulalia Bazán, Carlos Zaldo
This work presents the synthesis by coprecipitation of diamond shaped Yb:Er:NaGd(WO<sub>4</sub>)<sub>2</sub> crystalline nanoparticles (NPs) with diagonal dimensions in the 5-7 nm × 10-12 nm range which have been modified with TWEEN80 for their dispersion in water, and their interaction with mesenchymal stem cells (MSCs) proposed as cellular NP vehicles. These NPs belong to a large family of tetragonal Yb:Er:NaT(XO<sub>4</sub>)<sub>2</sub> (T=Y, La, Gd, Lu; X= Mo, W) compounds with green (<sup>2</sup>H<sub>11/2</sub>+<sup>4</sup>S<sub>3/2</sub>→<sup>4</sup>I<sub>15/2</sub>) Er-related upconversion (UC) efficiency comparable to that of Yb:Er:β-NaYF<sub>4</sub> reference compound, but with a ratiometric thermal sensitivity (S) 2...
March 21, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28320556/-organization-and-preservation-of-the-collection-of-pathogenic-and-fungal-symbionts-of-insects-and-other-arthropods-from-cepave-conicet-unlp-la-plata-argentina
#5
Alejandra Concepción Gutierrez, Julieta Tornesello-Galván, Romina Guadalupe Manfrino, Marcela Hipperdinger, Marianel Falvo, Celeste D'Alessandro, Claudia Cristina López Lastra
The collection of fungal pathogens and symbionts of insects and other arthropods of the Centro de Estudios Parasitológicos y de Vectores, La Plata, Argentina, is unique because it preserves in vivo and in vitro cultures of fungal pathogens. This culture collection is open for research, teaching, consulting services, and strain deposit. It contains 421 strains belonging to 23 genera (16 Ascomycota, 4 Entomophthoromycotina, 2 Glomeromycota and 1 Oomycota), and the cultures are preserved by different methods such as cryopreservation in freezer at -20°C and -70°C, paper, distilled water and lyophilization...
March 17, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28302580/the-role-of-therapeutic-layering-in-optimizing-treatment-for-patients-with-castration-resistant-prostate-cancer-radar-ii
#6
E David Crawford, Daniel P Petrylak, Neal Shore, Fred Saad, Susan F Slovin, Nicholas J Vogelzang, Thomas E Keane, Phillip J Koo, Leonard G Gomella, Joe M O'Sullivan, Bertrand Tombal, Raoul S Concepcion, Paul Sieber, Nelson N Stone, Steven E Finkelstein, Evan Y Yu
OBJECTIVE: To offer recommendations on identification of disease progression, treatment management strategies, and suggestions on timing of initiating and discontinuing specific CRPC treatments. MATERIALS AND METHODS: The RADAR II [Prostate Cancer Radiographic Assessments for Detection of Advanced Recurrence] Working Group convened to provide guidance on sequencing, combination, or layering of approved treatments for mCRPC based on available data and clinical experience...
March 13, 2017: Urology
https://www.readbyqxmd.com/read/28291668/under-utilization-of-taps-in-intensive-care-unit-as-a-cause-of-reservoirs-of-nonfermenting-gram-negative-bacilli
#7
Gonzalo de-Las-Casas-Cámara, María Dolores Martín-Ríos, Maria Isabel Adillo-Montero, María Carmen Muñoz-Egea, Javier Zapardiel-Ferrero, Concepción Pérez-Jorge Peremarch
INTRODUCTION: The under-utilisation of taps is associated with the generation of reservoirs of non-fermenting gram-negative bacilli with the ability to disseminate. We describe the detection and approach of the problem in an ICU. METHODS: Observational descriptive study in an ICU with individual cubicles with their own sink. We collected clinical samples from patients and environmental samples from tap aerators and reviewed the unit's hygiene measures. RESULTS: We detected four cases due to Chryseobacterium indologenes, one to Elizabethkingia meningoseptica and another to Pseudomonas aeruginosa; they were identified both in clinical and the environmental samples...
March 10, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28286296/snowy-cotyledon-2-promotes-chloroplast-development-and-has-a-role-in-leaf-variegation-in-both-lotus-japonicus-and-arabidopsis-thaliana
#8
Nicola Zagari, Omar Sandoval-Ibañez, Niels Sandal, Junyi Su, Manuel Rodriguez-Concepcion, Jens Stougaard, Mathias Pribil, Dario Leister, Pablo Pulido
Plants contain various factors that transiently interact with subunits or intermediates of the thylakoid multiprotein complexes, promoting their stable association and integration. Hence, assembly factors are essential for chloroplast development and the transition from heterotrophic to phototrophic growth. Snowy cotyledon 2 (SCO2) is a DNAJ-like protein involved in thylakoid membrane biogenesis, and it interacts with the light-harvesting chlorophyll-binding protein LHCB1. In Arabidopsis thaliana, SCO2 function was described to be restricted to cotyledons, but here we show that in Lotus japonicus absence of SCO2 results not only in paler cotyledons but also in variegated true leaves...
March 9, 2017: Molecular Plant
https://www.readbyqxmd.com/read/28284772/development-of-a-checklist-for-patients-with-axial-spondyloarthritis-and-psoriatic-arthritis-in-daily-practice-only-tools-project
#9
Raquel Almodovar, Juan C Torre Alonso, Enrique Batlle, Concepción Castillo, Eduardo Collantes-Estevez, Eugenio de Miguel, Senén González, Jordi Gratacós, Azucena Hernández, Xavier Juanola, Luis F Linares, Manuel J Moreno, Mireia Moreno, Victoria Navarro-Compán, Carlos Rodríguez Lozano, Jesus Sanz, Agustí Sellas, Estíbaliz Loza, Pedro Zarco
OBJECTIVE: To standardize clinical evaluation of patients with axial spondyloarthritis (SpA) and psoriatic arthritis (PsA) using a checklist. METHODS: Qualitative study that included: 1) nominal group (18 experts); 2) literature reviews of measures used in the assessment of patients with axial SpA or PsA; and 3) focus groups, one with rheumatologists and another with patients, organized to become familiar with their opinion on medical assistance. Taking this into account, the experts selected the measures to be included in the checklist based on their relevance, feasibility, and the outcome type...
March 8, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28280303/in-silico-discovery-and-in-vitro-activity-of-inhibitors-against-mycobacterium-tuberculosis-7-8-diaminopelargonic-acid-synthase-mtb-bioa
#10
Junie B Billones, Maria Constancia O Carrillo, Voltaire G Organo, Jamie Bernadette A Sy, Nina Abigail B Clavio, Stephani Joy Y Macalino, Inno A Emnacen, Alexandra P Lee, Paul Kenny L Ko, Gisela P Concepcion
Computer-aided drug discovery and development approaches such as virtual screening, molecular docking, and in silico drug property calculations have been utilized in this effort to discover new lead compounds against tuberculosis. The enzyme 7,8-diaminopelargonic acid aminotransferase (BioA) in Mycobacterium tuberculosis (Mtb), primarily involved in the lipid biosynthesis pathway, was chosen as the drug target due to the fact that humans are not capable of synthesizing biotin endogenously. The computational screening of 4...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28278193/a-bcr-abl1-cutoff-of-1-5-at-3-months-determined-by-the-genexpert-system-predicts-an-optimal-response-in-patients-with-chronic-myeloid-leukemia
#11
Valentín García-Gutiérrez, María T Gómez-Casares, José M Puerta, Juan M Alonso-Domínguez, Santiago Osorio, Juan C Hernández-Boluda, Rosa Collado, María J Ramírez, Fátima Ibáñez, María L Martín, Juan D Rodríguez-Gambarte, Carolina Martínez-Laperche, Montse Gómez, Dolly V Fiallo, Sara Redondo, Alicia Rodríguez, Concepción Ruiz-Nuño, Juan L Steegmann, Antonio Jiménez-Velasco
In chronic myeloid leukemia (CML) patients, 3-month BCR-ABL1 levels have consistently been correlated with further outcomes. Monitoring molecular responses in CML using the GeneXpert (Cepheid) platform has shown an optimal correlation with standardized RQ-PCR (IS) when measuring BCR-ABL1 levels lower than 10%, as it is not accurate for values over 10%. The aim of the present study was to determine the predictive molecular value at three months on different outcome variables using the Xpert BCR-ABL1 MonitorTM assay (Xpert BCR-ABL1)...
2017: PloS One
https://www.readbyqxmd.com/read/28278165/indomethacin-counteracts-the-effects-of-chronic-social-defeat-stress-on-emotional-but-not-recognition-memory-in-mice
#12
Aránzazu Duque, Concepción Vinader-Caerols, Santiago Monleón
We have previously observed the impairing effects of chronic social defeat stress (CSDS) on emotional memory in mice. Given the relation between stress and inflammatory processes, we sought to study the effectiveness of the anti-inflammatory indomethacin in reversing the detrimental effects of CSDS on emotional memory in mice. The effects of CSDS and indomethacin on recognition memory were also evaluated. Male CD1 mice were randomly divided into four groups: non-stressed + saline (NS+SAL); non-stressed + indomethacin (NS+IND); stressed + saline (S+SAL); and stressed + indomethacin (S+IND)...
2017: PloS One
https://www.readbyqxmd.com/read/28278036/emission-factors-of-particulate-matter-polycyclic-aromatic-hydrocarbons-and-levoglucosan-from-wood-combustion-in-south-central-chile
#13
Jorge Jimenez, Oscar Farias, Roberto Quiroz, Jorge Yañez
In south central Chile, wood stoves have been identified as an important source of air pollution in populated areas. Eucalyptus (eucalyptus globulus), Chilean oak (nothofagus oblique) and mimosa (acacia dealbata) were burned in a single chamber slow combustion wood stove at a controlled testing facility located at the University of Concepción, Chile. 2.7-3.1 kg of firewood were combusted in each experiment while continuously monitoring temperature, exhaust gases, burn rate, and collecting particulate matter samples in Teflon filters under isokinetic conditions for polycyclic aromatic hydrocarbons and levoglucosan analyses...
February 22, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28277974/both-hsp70-chaperone-and-clp-protease-plastidial-systems-are-required-for-protection-against-oxidative-stress
#14
Pablo Pulido, Ernesto Llamas, Manuel Rodriguez-Concepcion
Environmental stress conditions such as high light, extreme temperatures, salinity or drought trigger oxidative stress and eventually protein misfolding in plants. In chloroplasts, chaperone systems refold proteins after stress, while proteases degrade misfolded and aggregated proteins that cannot be refolded. We observed that reduced activity of chloroplast Hsp70 chaperone or Clp protease systems both prevented growth of Arabidopsis thaliana seedlings after treatment with the oxidative agent methyl viologen...
February 14, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28277866/treatment-for-chronic-low-back-pain-the-focus-should-change-to-multimodal-management-that-reflects-the-underlying-pain-mechanisms
#15
Gerhard Müller-Schwefe, Bart Morlion, Karsten Ahlbeck, Eli Alon, Stefano Coaccioli, Flaminia Coluzzi, Frank Huygen, Wolfgang Jaksch, Eija Kalso, Magdalena Kocot-Kępska, Hans-Georg Kress, Ana Cristina Mangas, Cesar Margarit Ferri, Philippe Mavrocordatos, Andrew Nicolaou, Concepción Pérez Hernández, Joseph Pergolizzi, Michael Schäfer, Patrick Sichère
Chronic low back pain: Chronic pain is the most common cause for people to utilize healthcare resources and has a considerable impact upon patients' lives. The most prevalent chronic pain condition is chronic low back pain (CLBP). CLBP may be nociceptive or neuropathic, or may incorporate both components. The presence of a neuropathic component is associated with more intense pain of longer duration, and a higher prevalence of co-morbidities. However, many physicians' knowledge of chronic pain mechanisms is currently limited and there are no universally accepted treatment guidelines, so the condition is not particularly well managed...
March 22, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28264907/increased-pilus-production-conferred-by-a-naturally-occurring-mutation-alters-host-pathogen-interaction-in-favor-of-carriage-in-streptococcus-pyogenes
#16
Anthony R Flores, Randall J Olsen, Concepcion Cantu, Kyler B Pallister, Fermin E Guerra, Jovanka M Voyich, James M Musser
Studies of the human pathogen group A Streptococcus (GAS) define the carrier phenotype as increased ability to adhere to and persist on epithelial surfaces and decreased ability to cause disease. We tested the hypothesis that a single amino acid change (Arg135Gly) in a highly conserved sensor kinase (LiaS) of a poorly defined GAS regulatory system contributes to a carrier phenotype through increased pilus production. When introduced into an emm serotype-matched invasive strain, the carrier allele (liaS(R135G)) recapitulated a carrier phenotype defined by increased ability to adhere to mucosal surfaces and decreased ability to cause disease...
March 6, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28264770/comparative-effect-of-zno-nps-zno-bulk-and-znso4-in-the-antioxidant-defences-of-two-plant-species-growing-in-two-agricultural-soils-under-greenhouse-conditions
#17
Concepción García-Gómez, Ana Obrador, Demetrio González, Mar Babín, María Dolores Fernández
The present study has investigated the toxicity of ZnO NPs to bean (Phaseolus vulgaris) and tomato (Solanum lycopersicon) crops grown to maturity under greenhouse conditions using an acidic (soil pH5.4) and a calcareous soil (soil pH8.3). The potentially available Zn in the soils and the Zn accumulation in the leaves from NPs applied to the soil (3, 20 and 225mgZnkg(-1)) and changes in the chlorophylls, carotenoids and oxidative stress biomarkers were measured at 15, 30, 60 and 90days and compared with those caused by bulk ZnO and ZnSO4...
March 3, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28264302/updated-list-of-bumblebees-hymenoptera-apidae-from-the-spanish-pyrenees-with-notes-on-their-decline-and-conservation-status
#18
Concepción Ornosa, Félix Torres, Pilar DE LA Rúa
The Pyrenees, where Euro-Siberian, Mediterranean and alpine faunas join together, have a large biodiversity of bumblebees. We compiled historical literature records of bumblebee species from the Spanish Pyrenees, and then compared these to contemporary surveys to assess trends in elevational distribution. Twenty-eight species (including thirty-five subspecies) were found in the contemporary survey. Nine species and two subspecies previously present were not detected, some included on the Spanish Red List. With the exception of a few species, a reduction of the altitudinal range and an orophilous tendency was observed at both upper and lower elevational levels, suggesting an upward trend towards better-preserved high areas...
February 26, 2017: Zootaxa
https://www.readbyqxmd.com/read/28258194/antiparasitic-treatment-induces-an-improved-cd8-t-cell-response-in-chronic-chagasic-patients
#19
Jose Mateus, Elena Pérez-Antón, Paola Lasso, Adriana Egui, Nubia Roa, Bartolomé Carrilero, John M González, M Carmen Thomas, Concepción J Puerta, Manuel C López, Adriana Cuéllar
Chagas disease is a chronic infection caused by Trypanosoma cruzi, an intracellular protozoan parasite. Chronic chagasic patients (CCPs) have dysfunctional CD8(+) T cells that are characterized by impaired cytokine production, high coexpression of inhibitory receptors, and advanced cellular differentiation. Most patients diagnosed in the chronic phase of Chagas disease already exhibit heart involvement, and there is no vaccination that protects against the disease. Antiparasitic treatment is controversial as to its indication for this stage of the disease...
March 3, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28257495/correction-an-increase-in-visceral-fat-is-associated-with-a-decrease-in-the-taste-and-olfactory-capacity
#20
Jose Carlos Fernandez-Garcia, Juan Alcaide, Concepcion Santiago-Fernandez, M M Roca-Rodriguez, Zaida Aguera, Rosa Baños, Cristina Botella, Rafael de la Torre, Jose M Fernandez-Real, Gema Fruhbeck, Javier Gomez-Ambrosi, Susana Jimenez-Murcia, Jose M Menchon, Felipe F Casanueva, Fernando Fernandez-Aranda, Francisco J Tinahones, Lourdes Garrido-Sanchez
[This corrects the article DOI: 10.1371/journal.pone.0171204.].
2017: PloS One
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