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https://www.readbyqxmd.com/read/29125176/hplc-dad-esi-ms-ms-analysis-of-fruits-from-firmiana-simplex-l-and-evaluation-of-their-antioxidant-and-antigenotoxic-properties
#1
Mosad Ahmed Ghareeb, Tamer Mohamed, Amal Mohamed Saad, Laila Abdel-Ghany Refahy, Mansour Sobeh, Michael Wink
OBJECTIVES: The secondary metabolites of the fruits of Firmiana simplex (L.) were analysed by LC-DAD-ESI-MS/MS; furthermore, we evaluated their antioxidant and antigenotoxic properties. METHODS: The antioxidant activity was investigated using the 2,2'-diphenyl-1-picrylhydrazyl radical (DPPH), the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) and the ferric reducing antioxidant power (FRAP) assays. The antigenotoxic potential was determined via the comet assay...
November 10, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29104051/non-covalent-dna-binding-protein-interaction-dna-cleavage-and-cytotoxicity-of-cu-quamol-cl-%C3%A2-h2o
#2
Somasundaram Sangeetha, Mariappan Murali
A copper(II) complex [Cu(II)(quamol)Cl]·H2O, where H(quamol) is N-2-(quinolyl-methylidene)aminophenol, has been isolated. The solution structure of the complex has been assessed to be distorted square-planar. The complex displays a ligand field band in the visible region (608nm) and also show axial EPR spectrum in DMF at 77K with g||>g⊥ indicating a dx(2)-y(2) ground state. The g|| and A|| values of 2.265 and 153×10(-4)cm(-1), respectively, conform to a square-based CuN2OCl chromophore. The interaction of the complex with calf thymus (CT) DNA has been explored by using absorption (Kb=2...
November 2, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29080461/l-ascorbic-acid-2-glucoside-inhibits-helicobacter-pylori-induced-apoptosis-through-mitochondrial-pathway-in-gastric-epithelial-cells
#3
Xiong Chen, Rui Liu, Xiaoming Liu, Canxia Xu, Xiaoyan Wang
Helicobacter pylori (H. pylori) infection is the major cause for gastritis, peptic ulcer, and gastric cancer. Elevated oxidative stress, mitochondrial dysfunction and apoptotic death of gastric epithelial cells are typical hallmarks of H. pylori infection. Ascorbic Acid 2-Glucoside (AA2G) is a stable version of Vitamin C, that binds glucose to conventional vitamin C. AA2G has free radical scavenging activities and anti-apoptotic abilities. However, the protective effect of AA2G against H. pylori-infection in gastric epithelial cells is yet unknown...
October 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29079526/synergistic-enhancement-of-topotecan-induced-cell-death-by-ascorbic-acid-in-human-breast-mcf-7-tumor-cells
#4
Birandra K Sinha, Thomas J van 't Erve, Ashutosh Kumar, Carl D Bortner, Ann G Motten, Ronald P Mason
Topotecan, a derivative of camptothecin, is an important anticancer drug for the treatment of various human cancers in the clinic. While the principal mechanism of tumor cell killing by topotecan is due to its interactions with topoisomerase I, other mechanisms, e.g., oxidative stress induced by reactive free radicals, have also been proposed. However, very little is known about how topotecan induces free radical-dependent oxidative stress in tumor cells. In this report we describe the formation of a topotecan radical, catalyzed by a peroxidase-hydrogen peroxide system...
October 24, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29069637/redox-active-metals-and-h2o2-mediate-the-increased-efficacy-of-pharmacological-ascorbate-in-combination-with-gemcitabine-or-radiation-in-pre-clinical-sarcoma-models
#5
Joshua D Schoenfeld, Zita A Sibenaller, Kranti A Mapuskar, Megan D Bradley, Brett A Wagner, Garry R Buettner, Varun Monga, Mohammed Milhem, Douglas R Spitz, Bryan G Allen
Soft tissue sarcomas are a histologically heterogeneous group of rare mesenchymal cancers for which treatment options leading to increased overall survival have not improved in over two decades. The current study shows that pharmacological ascorbate (systemic high dose vitamin C achieving ≥ 20mM plasma levels) is a potentially efficacious and easily integrable addition to current standard of care treatment strategies in preclinical models of fibrosarcoma and liposarcoma both in vitro and in vivo. Furthermore, enhanced ascorbate-mediated toxicity and DNA damage in these sarcoma models were found to be dependent upon H2O2 and intracellular labile iron...
September 28, 2017: Redox Biology
https://www.readbyqxmd.com/read/29049940/photocatalytic-degradation-of-synthetic-food-dye-sunset-yellow-fcf-fd-c-yellow-no-6-by-ailanthus-excelsa-roxb-possessing-antioxidant-and-cytotoxic-activity
#6
Subramanyam Deepika, Rajendran Harishkumar, Murugesan Dinesh, Rajadurai Abarna, Moorthy Anbalagan, Selvaraj Mohana Roopan, Chinnadurai Immanuel Selvaraj
The purpose of our work is to identify the bioactive compounds of bark and leaves extract from Ailanthus excelsa Roxb. and to explore its effectiveness against synthetic food dye. The presence of primary and secondary metabolites was confirmed by carrying out phytochemicals analysis. With the prior knowledge accessible on the indispensable secondary metabolites holding antioxidant and cytotoxicity activity, the quantitative screening of total phenolic and flavonoid content in methanolic and aqueous extract of bark and leaves from Ailanthus excelsa were done...
October 12, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29040832/biological-evaluation-of-surface-modified-magnetic-nanoparticles-as-a-platform-for-colon-cancer-cell-theranostics
#7
Maksym Moskvin, Michal Babič, Salette Reis, M Margarida Cruz, Liliana P Ferreira, Maria Deus Carvalho, Sofia A Costa Lima, Daniel Horák
Magnetic nanoparticles offer multiple possibilities for biomedical applications. Besides their physico-chemical properties, nanoparticle-cellular interactions are determinant for biological safety. In this work, magnetic nanoparticles were synthesized by one-shot precipitation or two-step reaction and coated with biocompatible polymers, such as poly(l-lysine) and poly(N,N-dimethylacrylamide-co-acrylic acid), and carbohydrates, like l-ascorbic acid, d-galactose, d-mannose, and sucrose. The resulting magnetic nanoparticles were characterized by dynamic light scattering, FT-Raman spectroscopy, transmission electron microscopy, SQUID magnetometry, and Mössbauer spectroscopy...
October 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29017880/development-physicochemical-characterization-and-cytotoxicity-of-selenium-nanoparticles-stabilized-by-beta-lactoglobulin
#8
Jinglin Zhang, Zi Teng, Yang Yuan, Qing-Zhu Zeng, Zhiyuan Lou, Seong-Ho Lee, Qin Wang
Novel Selenium nanoparticles (SeNPs) were developed using beta-lactoglobulin (Blg) as a stabilizer in redox systems of selenite and ascorbic acid in this study. Particle size, morphology, stability, and in vitro biological activity of synthesized Blg stabilized selenium nanoparticles (Blg-SeNPs) were characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), ultraviolet-visible spectrophotometry (UV/Vis), and cell toxicity assays, respectively. Stabilizing mechanisms of Blg-SeNPs were investigated by Fourier-transform infrared spectroscopy (FTIR) and protein fluorescence probe...
October 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28987078/brief-report-stability-and-chemical-characteristics-of-injectable-ascorbic-acid-for-patients-with-cancer
#9
Daniel A Monti, Anthony J Bazzan, George Zabrecky, Andrew B Newberg
Context • Intravenous ascorbic acid (IVAA) has been used extensively as part of the management plan for cancer patients in various medical clinics throughout the United States. The current research team has evaluated its effectiveness in patients with cancer as part of an ongoing research program. However, no data are available that support the chemical stability of intravenously injectable ascorbic acid (AA) to ensure its safety and efficacy in that patient population. Its clinical use as well as its use in research conducted in US Food and Drug Administration-approved clinical trials require validation of its stability...
October 2, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28974112/concentration-does-matter-the-beneficial-and-potentially-harmful-effects-of-ascorbate-in-humans-and-plants
#10
Szilvia Zita Tóth, Tamás Lőrincz, András Szarka
SIGNIFICANCE: Ascorbate is an essential compound both in animals and plants, mostly due to its reducing properties, thereby playing a role in scavenging reactive oxygen species and acting as a cofactor in various enzymatic reactions. Recent Advances: Growing number of evidence show that excessive ascorbate accumulation may have negative effects on cellular functions both in humans and plants, inter alia it may negatively affect signaling mechanisms, cellular redox status and contribute to the production of reactive oxygen species via the Fenton reaction...
October 3, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28972460/tumor-regression-and-modulation-of-gene-expression-via-tumor-targeted-tocotrienol-niosomes
#11
Doryn Meam-Yee Tan, Ju-Yen Fu, Fu-Shun Wong, Hui-Meng Er, Yu-Sui Chen, Kalanithi Nesaretnam
AIM: To develop 6-O-palmitoyl-ascorbic acid-based niosomes targeted to transferrin receptor for intravenous administration of tocotrienols (T3) in breast cancer. MATERIALS & METHODS: Niosomes were prepared using film hydration and ultrasonication methods. Transferrin was coupled to the surface of niosomes via chemical linker. Nanovesicles were characterized for size, zeta potential, morphology, stability and biological efficacy. RESULTS: When evaluated in MDA-MB-231 cells, entrapment of T3 in niosomes caused 1...
October 2017: Nanomedicine
https://www.readbyqxmd.com/read/28964888/egfr-her2-target-based-molecular-docking-analysis-in-vitro-screening-of-2-4-5-trisubstituted-imidazole-derivatives-as-potential-anti-oxidant-and-cytotoxic-agents
#12
Ramu Guda, Girijesh Kumar, Rajashekar Korra, Siripireddy Balaji, Govindu Dayakar, Rambabu Palabindela, Prabhakar Myadaraveni, Narsimha Reddy Yellu, Mamatha Kasula
In our endeavor towards the development of potent molecules for cancer diseases, we have designed and synthesized a series of 2,4,5-trisubstituted imidazole derivatives (B1-B24) and characterized by using various spectroscopic techniques. All these compounds are further evaluated for their in vitro anti-cancer, anti-oxidant activities and molecular docking studies against EGFR, HER2 protein receptors. The in vitro anti-cancer activity analysis reveals that compounds B11 and B16 were found to be effective scaffolds against the tested human cancer cell lines IMR-32, A549 and HeLa...
September 18, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28958933/pyruvate-diminishes-the-cytotoxic-activity-of-ascorbic-acid-in-several-tumor-cell-lines-in%C3%A2-vitro
#13
Sandra Rodemeister, Katharina Hill
The anticancer potential of ascorbic acid (AA) has been controversially discussed for decades. Although the cytotoxic effect of pharmacologic concentrations of ascorbic acid has already been successfully demonstrated in numerous studies in vitro, it could not be verified to the same extent in vivo. We propose that the ubiquitous metabolite pyruvate diminishes the effect of AA by reacting with its presumable cytotoxic mediator hydrogen peroxide (H2O2). MTT assays confirm that co-incubation with 1.4 mM pyruvate abolishes the cytotoxic effect of pharmacologic concentrations of AA in all cancer cell lines tested (human melanoma (WM451-Lu), breast (MCF-7) and hypopharyngeal cancer cells (FaDu))...
November 25, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28955751/2-o-%C3%AE-d-glucopyranosyl-l-ascorbic-acid-as-an-antitumor-agent-for-infusion-therapy
#14
Kaori Miura, Akihiro Tai
Ascorbic acid (AA) has been reported as a treatment for cancer patients. Intravenous (iv) administration of high-dose AA increases plasma AA levels to pharmacologic concentrations and generates reactive oxygen species (ROS) to exert anti-tumor activity via enhancement of oxidative stress. However, AA is very unstable in aqueous solutions and it is impossible to preserve AA for a long period in a solution. 2-O-α-D-Glucopyranosyl-l-ascorbic acid (AA-2G), which is a glucoside derivative of AA, has been found to exhibit much higher stability than AA in aqueous solutions and it shows vitamin C activity after enzymatic hydrolysis to AA...
July 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28954710/mechanisms-of-anti-cancer-effects-of-ascorbate-cytotoxic-activity-and-epigenetic-modulation
#15
REVIEW
Domenico Mastrangelo, Elvira Pelosi, Germana Castelli, Francesco Lo-Coco, Ugo Testa
Vitamin C (Vit C or Ascorbate) is essential for many fundamental biochemical processes. Vit C is an essential nutrient with redox functions at normal physiologic concentrations. The main physiologic function of this vitamin is related to its capacity to act as a co-factor for a large family of enzymes, collectively known as Fe and 2-oxoglutarate-dependent dioxygenases. It also modulates epigenetic gene expression through the control of TET enzymes activity. Vit C also has several biological properties allowing to restore the deregulated epigenetic response observed in many tumors...
September 21, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28937732/reducing-agent-assisted-excessive-galvanic-replacement-mediated-seed-mediated-synthesis-of-porous-gold-nanoplates-and-highly-efficient-gene-thermo-cancer-therapy
#16
Seounghun Kang, Kyunglee Kang, Hyun Huh, Hyungjun Kim, Sung-Jin Chang, Tae Jung Park, Ki Soo Chang, Dal-Hee Min, Hongje Jang
Porous Au nanoplates (pAuNPs) were manufactured by a reducing agent-assisted galvanic replacement reaction on Ag nanoplates using a seed-mediated synthetic approach. Two core additives, poly(vinylpyrrolidone) and l-ascorbic acid, prevented fragmentation and proceeded secondary growth. By controlling the concentration of the additives and the amount of replacing ion AuCl4(-), various nanostructures including nanoplates with holes, nanoframes, porous nanoplates, and bumpy nanoparticles with unity and homogeneity were synthesized...
October 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28930270/protective-effects-of-six-selected-dietary-compounds-against-leptin-induced-proliferation-of-oestrogen-receptor-positive-mcf-7-breast-cancer-cells
#17
Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon, Sameera Ranganath Samarakoon, Ira Thabrew, E Dilip de Silva
BACKGROUND: Obesity is considered as one of the risk factors for breast cancer. Leptin has been found to be involved in breast cancer progression. Therefore, novel approaches to antagonize biological effects of leptin are much needed. The objective of this study was to evaluate the protective effects of six dietary compounds (quercetin, curcumin, gallic acid, epigallocatechin gallate (EGCG), ascorbic acid and catechin) and assess the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) in leptin-stimulated MCF-7 breast cancer cells in vitro...
July 26, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28919468/a-copper-based-enzyme-free-fluorescence-elisa-for-her2-detection
#18
Shiyu Tian, Ke Zeng, Aijun Yang, Qin Wang, Minghui Yang
We reported an enzyme-free ELISA to detect breast cancer biomarker human epidermal growth factor receptor 2 (HER2) in human serum samples. Instead of enzymes (such as horseradish peroxidase) used in traditional ELISA, CuO nanoparticles were utilized as the signal probe. Compared to traditional enzymes, CuO nanoparticles have the advantages of low cost and good stability. After dissolving CuO nanoparticles with acid, the Cu (II) ions generated catalyzed the reaction of o-phenylenediamine with ascorbic acid to produce fluorescent quinoxaline derivative molecules...
September 14, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28918353/antitumor-platinum-iv-derivatives-of-carboplatin-and-the-histone-deacetylase-inhibitor-4-phenylbutyric-acid
#19
Awatif Rashed Z Almotairy, Valentina Gandin, Liam Morrison, Cristina Marzano, Diego Montagner, Andrea Erxleben
Five new platinum(IV) derivatives of carboplatin each incorporating the histone deacetylase inhibitor 4-phenylbutyrate in axial position were synthesized and characterized by (1)H and (195)Pt NMR spectroscopy, electrospray ionization mass spectrometry and elemental analysis, namely cis,trans-[Pt(CBDCA)(NH3)2(PBA)(OH)] (1), cis,trans-[Pt(CBDCA)(NH3)2(PBA)2] (2), cis,trans-[Pt(CBDCA)(NH3)2(PBA)(bz)] (3), cis,trans-[Pt(CBDCA)(NH3)2(PBA)(suc)] (4) and cis,trans-[Pt(CBDCA)(NH3)2)(PBA)(ac)] (5) (PBA=4-phenylbutyrate, CBDCA=1,1-cyclobutane dicarboxylate, bz=benzoate, suc=succinate and ac=acetate)...
September 10, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28917640/biotinylated-platinum-iv-complexes-designed-to-target-cancer-cells
#20
Jian Zhao, Wuyang Hua, Gang Xu, Shaohua Gou
Three biotinylated platinum(IV) complexes (1-3) were designed and synthesized. The resulting platinum(IV) complexes exhibited effective cytotoxicity against the tested cancer cell lines, especially complex 1, which was 2.0-9.6-fold more potent than cisplatin. These complexes were found to be rapidly reduced to their activated platinum(II) counterparts by glutathione or ascorbic acid under biologically relevant condition. Additional molecular docking studies revealed that the biotin moieties of all Pt(IV) complexes can effectively bind with the streptavidin through the noncovalent interactions...
November 2017: Journal of Inorganic Biochemistry
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