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Stroke Medicine

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https://www.readbyqxmd.com/read/29778312/biomarker-signatures-of-sickle-cell-disease-severity
#1
Mengtian Du, Sarah Van Ness, Victor Gordeuk, Sayed M Nouraie, Sergei Nekhai, Mark Gladwin, Martin H Steinberg, Paola Sebastiani
Identifying sickle cell disease patients at high risk of complications could lead to personalized treatment and better prognosis but despite many advances prediction of the clinical course of these patients remains elusive. We propose a system-type approach to discover profiles of multiple, common biomarkers that correlate with morbidity and mortality in sickle cell disease. We used cluster analysis to discover 17 signatures of 17 common circulating biomarkers in 2320 participants of the Cooperative Study of Sickle Cell Disease, and evaluated the association of these signatures with risk for stroke, pain, leg ulceration, acute chest syndrome, avascular necrosis, seizure, death, and trend of fetal hemoglobin and hemolysis using longitudinally collected data...
May 16, 2018: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/29777510/clopidogrel-pharmacogenetics-in-iranian-patients-undergoing-percutaneous-coronary-intervention
#2
Nejat Mahdieh, Ahmad Rabbani, Ata Firouzi, Ali Zahedmehr, Maryam Hoseinimoghaddam, Sedigheh Saeidi, Hamidreza Sanati, Hosseinali Basiri, Feridoun Noohi, Bahareh Rabbani, Majid Maleki
Clopidogrel is used in patients with coronary syndromes and at risk of thrombotic events or receiving percutaneous coronary intervention (PCI) for reducing heart attack and stroke. Here we present genotype and phenotype study of Iranian patients undergoing PCI treated with clopidogrel during a 6-month period of follow-up; common variants of CYP2C19, CYP3A5, CYP3A4, and ABCB1 genes were determined as well as the patients' cardiovascular outcomes to find out the effect of these variants individually and in combination...
May 18, 2018: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29773912/development-and-evaluation-of-a-novel-system-for-inducing-orthostatic-challenge-by-tilt-tests-and-lower-body-negative-pressure
#3
Łukasz Dziuda, Mariusz Krej, Maciej Śmietanowski, Aleksander Sobotnicki, Mariusz Sobiech, Piotr Kwaśny, Anna Brzozowska, Paulina Baran, Krzysztof Kowalczuk, Franciszek W Skibniewski
Lower body negative pressure (LBNP) is a method derived from space medicine, which in recent years has been increasingly used by clinicians to assess the efficiency of the cardiovascular regulatory mechanisms. LBNP with combined tilt testing is considered as an effective form of training to prevent orthostatic intolerance. We have developed a prototype system comprising a tilt table and LBNP chamber, and tested it in the context of the feasibility of the device for assessing the pilots' efficiency. The table allows for controlled tilting in the range from -45 to +80° at the maximum change rate of 45°/s...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768250/metabolic-regulation-of-synaptic-activity
#4
Sergei V Fedorovich, Tatyana V Waseem
Brain tissue is bioenergetically expensive. In humans, it composes approximately 2% of body weight and accounts for approximately 20% of calorie consumption. The brain consumes energy mostly for ion and neurotransmitter transport, a process that occurs primarily in synapses. Therefore, synapses are expensive for any living creature who has brain. In many brain diseases, synapses are damaged earlier than neurons start dying. Synapses may be considered as vulnerable sites on a neuron. Ischemic stroke, an acute disturbance of blood flow in the brain, is an example of a metabolic disease that affects synapses...
May 16, 2018: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29765502/the-phenolic-components-of-gastrodia-elata-improve-prognosis-in-rats-after-cerebral-ischemia-reperfusion-by-enhancing-the-endogenous-antioxidant-mechanisms
#5
Anhuan Shi, Jianming Xiang, Fangyan He, Yanping Zhu, Gongbei Zhu, Yuhan Lin, Ningna Zhou
Pharmacological or spontaneous thrombolysis in ischemic stroke triggers an outbreak of reactive oxygen species and results in neuron death. Nrf2-mediated antioxidation in cells has been proved as a pivotal target for neuroprotection. This research reports that phenolic components of Gastrodia elata Blume (PCGE), a traditional Chinese medicine, can alleviate the pathological lesions in the penumbra and hippocampus by increasing the survival of neurons and astrocytes and improve neurofunction and cognition after reperfusion in a rat model of middle cerebral artery occlusion...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29764541/-tianjin-characteristics-of-integrated-traditional-chinese-and-western-medicine-in-first-aid-medical-system
#6
Zhijun Li
Tianjin, as the earliest city to open up, the exchange of Chinese and Western cultures also started earlier. Therefore, today's emergency medicine system with integrated features of Chinese and Western medicine is formed. Professor Wang Jinda, who works in Tianjin First Center Hospital, makes the theory of "treating bronchitis and treating diseases" and "three methods of three syndromes" for the treatment of severe diseases such as sepsis. The surgical aspect is the treatment of acute abdomen with the combination of Chinese and Western medicine which is proposed by Academician Wu Xianzhong who worked in Tianjin Nankai Hospital...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29758340/traditional-mongolian-medicine-eerdun-wurile-improves-stroke-recovery-through-regulation-of-gene-expression-in-rat-brain
#7
Saren Gaowa, Narisi Bao, Man Da, Qiburi Qiburi, Tsogzolmaa Ganbold, Lu Chen, Altanzul Altangerel, Temuqile Temuqile, Huricha Baigude
ETHNOPHARMACOLOGICAL RELEVANCE: Eerdun Wurile (EW) is one of the key Mongolian medicines for treatment of neurological and cardiological disorders. EW is ranked most regularly used Mongolian medicine in clinic. Components of EW which mainly originate from natural products are well defined and are unique to Mongolian medicine. AIM OF THE STUDY: Although the recipe of EW contains known neuroactive chemicals originated from plants, its mechanism of action has never been elucidated at molecular level...
May 11, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29755228/effect-of-1-week-yoga-based-residential-program-on-cardiovascular-variables-of-hypertensive-patients-a-comparative-study
#8
Kashinath G Metri, Balaram Pradhan, Amit Singh, H R Nagendra
Introduction: Hypertension (HTN) is an important public health concern and a leading cause of morbidity and mortality worldwide. Yoga is a form of mind-body medicine shown to be effective in controlling blood pressure (BP) and reduces cardiac risk factors in HTN. Integrated approach of Yoga therapy (IAYT) is a residential yoga-based lifestyle intervention proven to be beneficial in several health conditions. Aim: To study the efficacy of 1 week of residential IAYT intervention on cardiovascular parameters in hypertensive patients...
May 2018: International Journal of Yoga
https://www.readbyqxmd.com/read/29752869/allogeneic-umbilical-cord-blood-infusion-for-adults-with-ischemic-stroke-clinical-outcomes-from-a-phase-1-safety-study
#9
Daniel T Laskowitz, Ellen R Bennett, Rebecca J Durham, John J Volpi, Jonathan R Wiese, Michael Frankel, Elizabeth Shpall, Jeffry M Wilson, Jesse Troy, Joanne Kurtzberg
Stroke is a major cause of death and long-term disability, affecting one in six people worldwide. The only currently available approved pharmacological treatment for ischemic stroke is tissue plasminogen activator; however, relatively few patients are eligible for this therapy. We hypothesized that intravenous (IV) infusion of banked unrelated allogeneic umbilical cord blood (UCB) would improve functional outcomes in patients with ischemic stroke. To investigate this, we conducted a phase 1 open-label trial to assess the safety and feasibility of a single IV infusion of non-human leukocyte antigen (HLA) matched, ABO matched, unrelated allogeneic UCB into adult stroke patients...
May 12, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29748641/xiaoshuan-enteric-coated-capsule-alleviates-cognitive-impairment-by-enhancing-hippocampal-glucose-metabolism-hemodynamics-and-neuroplasticity-of-rat-with-chronic-cerebral-hypoperfusion
#10
Man-Zhong Li, Yi Zhang, Hai-Yan Zou, Ya-Li Wang, Brian-Chi Yan Cheng, Lei Wang, Qiu-Xia Zhang, Jian-Feng Lei, Hui Zhao
Chronic cerebral hypoperfusion (CCH) is identified as a critical risk factor of dementia in patients with cerebrovascular disease. Xiaoshuan enteric-coated capsule (XSECC) is a compound Chinese medicine approved by Chinese State Food and Drug Administration for promoting brain remodeling and plasticity after stroke. The present study aimed to explore the potential of XSECC to improve cognitive function after CCH and further investigate the underlying mechanisms. CCH was induced by bilateral common carotid artery occlusion (BCCAO) in rats...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29747670/the-efficacy-and-safety-of-jiedu-tongluo-granules-for-treating-post-stroke-depression-with-qi-deficiency-and-blood-stasis-syndrome-study-protocol-for-a-randomized-controlled-trial
#11
Ai-Mei Zhao, Wen-Ran Qiu, Li-Jun Mao, Jun-Guo Ren, Li Xu, Ming-Jiang Yao, Kellie Bilinksi, Dennis Chang, Jian-Xun Liu
BACKGROUND: Post-stroke depression (PSD) is the most common psychiatric complication after a stroke. The most frequently used antidepressants are selective serotonin receptor inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), however, these exhibit a series of side effects. Traditional Chinese medicine has been used to treat PSD with few side effects. The aim of this study is to evaluate the efficacy and safety of Jiedu Tongluo granules for treating PSD with qi deficiency and blood stasis syndrome...
May 10, 2018: Trials
https://www.readbyqxmd.com/read/29746193/chronic-obstructive-pulmonary-disease-and-stroke
#12
Alexandru Corlateanu, Serghei Covantev, Alexander G Mathioudakis, Victor Botnaru, Mario Cazzola, Nikolaos Siafakas
Chronic obstructive pulmonary disease (COPD) is currently the fourth leading cause of death in the world and its incidence and prevalence is on the rise. It is evident that COPD is linked to cardiovascular disease. In the last years, several studies demonstrated that COPD may also be a risk factor for stroke, another major cause of death worldwide. Taking in consideration that COPD has multiple comorbidities it is hard to say whether COPD is an independent risk factor for stroke or it is due to confounding effect...
May 10, 2018: COPD
https://www.readbyqxmd.com/read/29745441/appropriateness-of-oral-anticoagulant-therapy-prescription-and-its-associated-factors-in-hospitalized-older-people-with-atrial-fibrillation
#13
Carlotta Franchi, Stefania Antoniazzi, Marco Proietti, Alessandro Nobili, Pier Mannuccio Mannucci
BACKGROUND: Oral anticoagulants (OACs) are effective in preventing stroke in older people with atrial fibrillation (AF). Despite this, they are often underused in this at particularly high risk population. OBJECTIVES: To assess the appropriateness of OAC prescription and its associated factors in hospitalized patients aged 65 years or older. METHODS: Data were obtained from the retrospective phase of SIM-AF study, held in 32 Italian internal medicine and geriatric wards...
May 10, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29743322/protocol-for-a-randomised-controlled-trial-to-evaluate-the-effectiveness-of-the-care-for-stroke-intervention-in-india-a-smartphone-enabled-carer-supported-educational-intervention-for-management-of-disabilities-following-stroke
#14
K Sureshkumar, G V S Murthy, Hannah Kuper
INTRODUCTION: The rising prevalence of stroke and stroke-related disability witnessed globally over the past decades may cause an overwhelming demand for rehabilitation services. This situation is of concern for low-income and middle-income countries like India where the resources for rehabilitation are often limited. Recently, a smartphone-enabled carer-supported educational intervention for management of physical disabilities following stroke was developed in India. It was found to be feasible and acceptable, but evidence of effectiveness is lacking...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29742586/long-term-survival-of-young-patients-surviving-icu-admission-with-severe-sepsis
#15
Heba Abu-Kaf, Yuval Mizrakli, Victor Novack, Jacob Dreiher
OBJECTIVES: Sepsis remains a disease with a high mortality rate. The study goal was to assess long-term survival of severe sepsis in young patients. DESIGN: Retrospective cohort study. SETTING: Patients admitted with sepsis to ICUs in seven tertiary hospitals between 2003 and 2011. PATIENTS: A total of 409 patients less than 45 years who survived to hospital discharge were age and sex matched with 818 patients with infectious disease without sepsis selected from internal medicine or surgical department admissions...
May 7, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29742480/clinical-benefits-and-pharmacology-of-scutellarin-a-comprehensive-review
#16
REVIEW
Liping Wang, Qiang Ma
Stroke and myocardial infarction are among the most common causes of mortality and disability in the world. The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. The current drug therapy of choice is to timely resupply the blood to the ischemic tissue; but reperfusion may introduce additional harm to the tissue through a process known as ischemia/reperfusion injury...
May 6, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29739913/longitudinal-change-of-perceived-salt-intake-and-stroke-risk-in-a-chinese-population
#17
Yun Li, Zhe Huang, Cheng Jin, Aijun Xing, Yesong Liu, Chunmei Huangfu, Alice H Lichtenstein, Katherine L Tucker, Shouling Wu, Xiang Gao
BACKGROUND AND PURPOSE: Data for a relationship between salt intake and stroke have been inconsistent. This inconstancy could be because of the majority of studies evaluated salt intake at a single time point, which may be insufficient to accurately characterize salt intake throughout the observation period. METHODS: Included were 77 605 participants from the Kailuan study. We assessed perceived salt intake via questionnaire in 2006, 2008, and 2010. Salt intake trajectories from 2006 to 2010 were identified using latent mixture models...
May 8, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29738616/commentary-2018-stroke-guidelines
#18
Andrew D Perron
I read with interest (and some degree of disappointment) the new 2018 Stroke Guidelines published in January of this year that are labeled prominently "Endorsed by SAEM".1 To be clear, my disappointment has nothing to do with the use of tPA in acute ischemic stroke (I am happy to let others lead that charge). I am an admitted agnostic when it comes to the use of tPA (it helps some, it harms others, and we need to be really smart in its use to maximize the former and minimize the latter). Rather, it was notable to me that while the new guidelines touch a large number of specialties (Internal Medicine, Pharmacy, Nutrition, Rehabilitation, Radiology, Neurology, and Interventionalists to name a few), only one specialty merited a new Level 1A recommendation for targeted education This article is protected by copyright...
May 8, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29729639/method-development-and-application-for-multi-component-quantification-in-rats-after-oral-administration-of-longxuetongluo-capsule-by-uhplc-ms-ms
#19
Jing Sun, Huixia Huo, Yuelin Song, Jiao Zheng, Yunfang Zhao, Wenzhe Huang, Yonghua Wang, Jingbo Zhu, Pengfei Tu, Jun Li
Although wide applications towards ischemic stroke in clinic, the therapeutic materials of Longxuetongluo Capsule (LTC) that is composed of total phenolic extract of Chinese dragon's blood, are still largely unclear. Exposure pattern characterization of those drug-derived components in vivo, notably in circulation system has been recommended as a viable approach to disclose the effective components of a given herbal medicine. Herein, we aimed to develop a robust method being capable of multi-component quantification in either rat plasma or tissues following oral administration of LTC, and to clarify the kinetic profiles of 11 primary drug-derived phenolic derivatives...
April 22, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29729175/-the-correlation-between-body-composition-and-the-functional-state-of-cardiovascular-system-in-young-men-in-dependence-on-the-hemodynamics-types
#20
Marianna I Nemesh, Oksana P Kentesh, Olga S Palamarchuk, Olga E Kostenchak, Volodymyr P Feketa
OBJECTIVE: Introduction: The problem with overweight and the methods of antropomorphology analysis of the human body is actual in preventive medicine. The latest researches have shown doubt about the objectivity of the BMI for analysis the physical condition. As a result, scientists have presented new methods to analyse the human body. The aim: To find the correlation between the indices of body composition and functional condition of the cardiovascular system. PATIENTS AND METHODS: Materials and methods: The subject of this study were 48 young men with age from 18 to 25...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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