keyword
MENU ▼
Read by QxMD icon Read
search

BMS

keyword
https://www.readbyqxmd.com/read/29158087/fabp4-induces-asthmatic-airway-epithelial-barrier-dysfunction-via-ros-activated-foxm1
#1
Gaohui Wu, Liteng Yang, Yi Xu, Xiaohong Jiang, Xiaomin Jiang, Lisha Huang, Ling Mao, Shaoxi Cai
Functional abnormal airway epithelial cells, along with activated inflammatory cells, resulting in chronic airway inflammation, are considered as the characteristic of asthma. Fatty Acid Binding Protein 4 (FABP4) takes part in glucose and lipid homeostasis, and also have an important role in allergic airway inflammation. However, whether FABP4 influence barrier function of airway epithelial cells is unknown. In vivo, a HDM-induced murine model of asthma was obtained to assessed airway inflammation and protein expression of E-cadherin and Forkhead Box M1 (FoxM1)...
November 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29157203/survival-time-following-resection-of-intracranial-metastases-from-nsclc-development-and-validation-of-a-novel-nomogram
#2
Xiaoyu Ji, Yingjie Zhuang, Xiangye Yin, Qiong Zhan, Xinli Zhou, Xiaohua Liang
BACKGROUND: Brain metastases (BM) from non-small cell lung cancer (NSCLC) are the most frequent intracranial tumors. To identify patients who might benefit from intracranial surgery, we compared the six existing prognostic indexes(PIs) and built a nomogram to predict the survival for NSCLC with BM before they intended to receive total intracranial resection in China. METHODS: First, clinical data of NSCLC presenting with BM were retrospectively reviewed. All of the patients had received total intracranial resection and were randomly distributed to developing cohort and validation cohort by 2:1...
November 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29156085/the-association-between-burning-mouth-syndrome-and-sleep-disturbance-a-case-control-multicentre-study
#3
D Adamo, A Sardella, E Varoni, C Lajolo, M Biasotto, G Ottaviani, P Vescovi, T Simonazzi, M Pentenero, M Ardore, F Spadari, G Bombeccari, L Montebugnoli, D B Gissi, G Campisi, V Panzarella, M Carbone, L Valpreda, M Giuliani, M Aria, L Lo Muzio, M D Mignogna
OBJECTIVES: To investigate the quality of sleep and the psychological profiles of a large cohort of Italian patients with burning mouth syndrome (BMS) and to clarify the relationships between these variables and pain. METHODS: In this case-control study, 200 patients with BMS versus an equal number of age and sex-matched healthy controls, recruited in 10 Universities, were enrolled. The Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Hamilton Rating Scale for Depression (HAM-D), Hamilton Rating Scale for Anxiety (HAM-A), Numeric Pain Intensity Scale (NRS) and Total Pain Rating Index (T-PRI) were administered...
November 20, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29155879/subtypes-of-breast-cancer-show-different-spatial-distributions-of-brain-metastases
#4
Sunghyon Kyeong, Yoon Jin Cha, Sung Gwe Ahn, Sang Hyun Suh, Eun Ju Son, Sung Jun Ahn
The aim of our study was to test the hypothesis that the spatial distribution of breast cancer brain metastases (BM) differ according to their biological subtypes. MR images of 100 patients with BM from primary breast cancer were retrospectively reviewed. Patients were divided according to the biological subtype of the primary tumor, (triple-negative: 24, HER2 positive: 48, luminal: 28). All images marked with BMs were standardized to the human brain MRI atlas provided by the Montreal Neurological Institute 152 database...
2017: PloS One
https://www.readbyqxmd.com/read/29155559/crafting-of-neuroprotective-octapeptide-from-taxol-binding-pocket-of-%C3%AE-tubulin
#5
Prasenjit Mondal, Gaurav Das, Juhee Khan, Krishnangsu Pradhan, Surajit Ghosh
Microtubules play crucial role in maintaining the shape and function of neurons. During progression of Alzheimer's disease (AD), severe destabilization of microtubule occurs, which leads to the permanent disruption of signal transduction process and memory loss. Thus, microtubule stabilization is one of the key requirements for the treatment of AD. Taxol, a microtubule stabilizing anti-cancer drug has been considered as potential anti-AD drug but never tested in AD patients, likely because of its' toxic nature and poor brain exposure...
November 20, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29147135/randomized-clinical-trial-efficacy-and-safety-of-plecanatide-in-the-treatment-of-chronic-idiopathic-constipation
#6
Michael DeMicco, Laura Barrow, Bernadette Hickey, Kunwar Shailubhai, Patrick Griffin
Background: Plecanatide, with the exception of a single amino acid replacement, is identical to human uroguanylin and is approved in the United States for adults with chronic idiopathic constipation (CIC). This double-blind, placebo-controlled, phase III study evaluated the efficacy and safety of plecanatide versus placebo in CIC. Methods: Adults meeting modified Rome III CIC criteria were randomized to plecanatide 3 mg (n = 443), 6 mg (n = 449), or placebo (n = 445)...
November 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29133594/competitive-kinase-enrichment-proteomics-reveals-that-abemaciclib-inhibits-gsk3%C3%AE-and-activates-wnt-signaling
#7
Emily M Cousins, Dennis Goldfarb, Feng Yan, Jose Roques, David B Darr, Gary L Johnson, Michael B Major
The cellular and organismal phenotypic response to a small-molecule kinase inhibitor is defined collectively by the inhibitor's targets and their functions. The selectivity of small-molecule kinase inhibitors is commonly determined in vitro, using purified kinases and substrates. Recently, competitive chemical proteomics has emerged as a complementary, unbiased, cell-based methodology to define the target landscape of kinase inhibitors. Here, we evaluated and optimized a competitive multiplexed inhibitor bead mass spectrometry (MIB/MS) platform using cell lysates, live cells, and treated mice...
November 13, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29127000/drug-delivery-systems-functionalized-with-bone-mineral-seeking-agents-for-bone-targeted-therapeutics
#8
REVIEW
S G Rotman, D W Grijpma, R G Richards, T F Moriarty, D Eglin, O Guillaume
No abstract text is available yet for this article.
November 8, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29107047/moisture-induced-amorphous-phase-separation-of-amorphous-solid-dispersions-molecular-mechanism-microstructure-and-its-impact-on-dissolution-performance
#9
Huijun Chen, Yipshu Pui, Chengyu Liu, Zhen Chen, Ching-Chiang Su, Michael Hageman, Munir Hussain, Roy Haskell, Kevin Stefanski, Kimberly Foster, Olafur Gudmundsson, Feng Qian
Amorphous phase separation (APS) is commonly observed in amorphous solid dispersions (ASD) when exposed to moisture. The objective of this study was to investigate: 1) the phase behavior of amorphous solid dispersions composed of a poorly water-soluble drug with extremely low crystallization propensity, BMS-817399, and PVP, following exposure to different relative humidity (RH), and 2) the impact of phase separation on the intrinsic dissolution rate of amorphous solid dispersion. Drug-polymer interaction was confirmed in ASDs at different drug loading using Infrared (IR) spectroscopy and water vapor sorption analysis...
October 26, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29102583/endothelial-barrier-protein-expression-in-biodegradable-polymer-sirolimus-eluting-versus-durable-polymer-everolimus-eluting-metallic-stents
#10
Hiroyoshi Mori, Qi Cheng, Christoph Lutter, Samantha Smith, Liang Guo, Matthew Kutyna, Sho Torii, Emanuel Harari, Eduardo Acampado, Michael Joner, Frank D Kolodgie, Renu Virmani, Aloke V Finn
OBJECTIVES: This study sought to investigate endothelial coverage and barrier protein expression following stent implantation. BACKGROUND: Biodegradable polymer drug-eluting stents (BP-DES) have been purported to have biological advantages in vessel healing versus durable polymer DES (DP-DES), although clinical trial data suggest equipoise. METHODS: Biodegradable polymer-sirolimus-eluting stents (BP-SES), durable polymer-everolimus-eluting stents (DP-EES), and bare-metal stents (BMS) were compared...
October 25, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29102568/mosaic-osteochondral-autograft-transplantation-versus-bone-marrow-stimulation-technique-as-a-concomitant-procedure-with-opening-wedge-high-tibial-osteotomy-for-spontaneous-osteonecrosis-of-the-medial-femoral-condyle
#11
Ken Kumagai, Yasushi Akamatsu, Hideo Kobayashi, Yoshihiro Kusayama, Tomoyuki Saito
PURPOSE: To evaluate the effects of osteochondral autograft transplantation (OAT) mosaicplasty as a concomitant procedure with opening-wedge valgus high tibial osteotomy (HTO) for spontaneous osteonecrosis of the medial femoral condyle (MFC) on clinical outcomes and cartilage status in comparison with bone marrow stimulation (BMS) by drilling, and to assess the relation between lesion size and postoperative cartilage status. METHODS: Fifty-eight patients with spontaneous osteonecrosis of the MFC were treated with opening-wedge HTO and a concomitant procedure of BMS (28 patients) or OAT (30 patients)...
November 1, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29102362/drug-eluting-stents-in-elderly-patients-with-coronary-artery-disease-senior-a-randomised-single-blind-trial
#12
Olivier Varenne, Stéphane Cook, Georgios Sideris, Sasko Kedev, Thomas Cuisset, Didier Carrié, Thomas Hovasse, Philippe Garot, Rami El Mahmoud, Christian Spaulding, Gérard Helft, José F Diaz Fernandez, Salvatore Brugaletta, Eduardo Pinar-Bermudez, Josepa Mauri Ferre, Philippe Commeau, Emmanuel Teiger, Kris Bogaerts, Manel Sabate, Marie-Claude Morice, Peter R Sinnaeve
BACKGROUND: Elderly patients regularly receive bare-metal stents (BMS) instead of drug-eluting stents (DES) to shorten the duration of double antiplatelet therapy (DAPT). The aim of this study was to compare outcomes between these two types of stents with a short duration of DAPT in such patients. METHODS: In this randomised single-blind trial, we recruited patients from 44 centres in nine countries. Patients were eligible if they were aged 75 years or older; had stable angina, silent ischaemia, or an acute coronary syndrome; and had at least one coronary artery with a stenosis of at least 70% (≥50% for the left main stem) deemed eligible for percutaneous coronary intervention (PCI)...
October 31, 2017: Lancet
https://www.readbyqxmd.com/read/29099049/receptors-for-insulin-like-growth-factor-2-and-androgens-as-therapeutic-targets-in-triple-negative-breast-cancer
#13
Nalo Hamilton, David Austin, Diana Márquez-Garbán, Rudy Sanchez, Brittney Chau, Kay Foos, Yanyuan Wu, Jaydutt Vadgama, Richard Pietras
Triple-negative breast cancer (TNBC) occurs in 10-15% of all breast cancer patients, yet it accounts for about half of all breast cancer deaths. There is an urgent need to identify new antitumor targets to provide additional treatment options for patients afflicted with this aggressive disease. Preclinical evidence suggests a critical role for insulin-like growth factor-2 (IGF2) and androgen receptor (AR) in regulating TNBC progression. To advance this work, a panel of TNBC cell lines was investigated with all cell lines showing significant expression of IGF2...
November 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29096944/an-in-vitro-inflammation-model-to-study-the-nrf2-and-nf-%C3%AE%C2%BAb-crosstalk-in-presence-of-ferulic-acid-as-modulator
#14
Nadia Lampiasi, Giovanna Montana
The aim of this study was to evaluate the crosstalk between Nrf2 and NF-κB signaling pathways and to explore the modulating activity actuated by ferulic acid. In the inflammation process, a key player is the nuclear factor-κB (NF-κB) transcription factor pathway. On the contrary, the activation of Nrf2 inhibits inflammation and impairs degenerative disease providing an interface between redox and anti-inflammatory responses. Recent studies have demonstrated that protein phosphorylation of IKK complex is a potential mechanism for the activation of both Nrf2 and NF-κB pathways...
October 27, 2017: Immunobiology
https://www.readbyqxmd.com/read/29095656/fabrication-of-eudragit-polymeric-nanoparticles-using-ultrasonic-nebulization-method-for-enhanced-oral-absorption-of-megestrol-acetate
#15
Seo Young Dai, Su-Eon Jin, Daehyun Kim, Don Haeng Lee, Su-Geun Yang
Megestrol acetate (MGA) is used as a progestagen to treat advanced cancers in the breast or uterus and anorexia-cachexia syndrome in cancer patients. Due to its low solubility (BCS class II), MGA bioavailability needs to be enhanced for efficacy and safety. We developed MGA-encapsulated Eudragit(®) L100 (EUD) nanoparticles (MGA-EUD (1:1) and MGA-EUD (2:1)) using an ultrasonic nebulization method. MGA-EUD (1:1) and MGA-EUD (2:1) consisted of MGA and EUD at the mass ratios of 1:1 and 2:1. Their physicochemical properties, i...
November 2, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29093678/immune-related-adverse-events-associated-with-anti-pd-1-pd-l1-treatment-for-malignancies-a-meta-analysis
#16
Peng-Fei Wang, Yang Chen, Si-Ying Song, Ting-Jian Wang, Wen-Jun Ji, Shou-Wei Li, Ning Liu, Chang-Xiang Yan
Background: Treatment of cancers with programmed cell death protein 1 (PD-1) pathway inhibitors can lead to immune-related adverse events (irAEs), which could be serious and even fetal. Therefore, clinicians should be aware of the characteristics of irAEs associated with the use of such drugs. Methods: The MEDLINE, EMBASE, and Cochrane databases were searched to find potential studies using the following strategies: anti-PD-1/PD-L1 treatment; irAEs; and cancer. R© package Meta was used to pool incidence. Results: Forty-six studies representing 12,808 oncologic patients treated with anti-PD-1/PD-L1 agents were included in the meta-analysis...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29080817/production-and-structural-characterization-of-exopolysaccharides-from-newly-isolated-probiotic-lactic-acid-bacteria
#17
Yousra Abid, Angela Casillo, Houda Gharsallah, Ichrak Joulak, Rosa Lanzetta, Maria Michela Corsaro, Hamadi Attia, Samia Azabou
In this work, four exopolysaccharide-producing lactic acid bacteria (LAB) strains, newly isolated from Tunisian spontaneously fermented foods and beverages, namely bovine and turkey meat sausages (BMS and TMS), date palm sap (DPS) and cow milk (CM), were identified as Leuconostoc citreum-BMS, Leuconostoc mesenteroides-TMS, Pediococcus pentosaceus-DPS and Leuconostoc pseudomesenteroides-CM, respectively. The isolated strains showed the ability to withstand simulated human gastrointestinal (GI) tract conditions (low pH, lysozyme, bile salts, pepsin and pancreatin) and showed high surface hydrophobicity (79-90%), besides their ability to act against Escherichia coli and Listeria monocytogenes and to produce exopolysaccharides (EPS)...
October 25, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29077405/discovery-of-a-parenteral-small-molecule-coagulation-factor-xia-inhibitor-clinical-candidate-bms-962212
#18
Donald J P Pinto, Michael J Orwat, Leon M Smith, Mimi L Quan, Patrick Y S Lam, Karen A Rossi, Atsu Apedo, Jeffrey M Bozarth, Yiming Wu, Joanna J Zheng, Baomin Xin, Nathalie Toussaint, Paul Stetsko, Olafur Gudmundsson, Brad Maxwell, Earl J Crain, Pancras C Wong, Zhen Lou, Timothy W Harper, Silvi A Chacko, Joseph E Myers, Steven Sheriff, Huiping Zhang, Xiaoping Hou, Arvind Mathur, Dietmar A Seiffert, Ruth R Wexler, Joseph M Luettgen, William R Ewing
Factor XIa (FXIa) is a blood coagulation enzyme that is involved in the amplification of thrombin generation. Mounting evidence suggests that direct inhibition of FXIa can block pathologic thrombus formation while preserving normal hemostasis. Preclinical studies using a variety of approaches to reduce FXIa activity, including direct inhibitors of FXIa, have demonstrated good antithrombotic efficacy without increasing bleeding. On the basis of this potential, we targeted our efforts at identifying potent inhibitors of FXIa with a focus on discovering an acute antithrombotic agent for use in a hospital setting...
November 17, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29074941/orofacial-pain-an-update-on-diagnosis-and-management
#19
S Ghurye, R McMillan
The diagnosis and management of orofacial pain may be challenging due to complex histories, pathophysiology and associated psychosocial co-morbidities such as depression and anxiety. Neuropathic facial pain conditions such as burning mouth syndrome (BMS), persistent idiopathic facial pain (PIFP), atypical odontalgia (AO) and trigeminal neuralgia (TN) require early recognition by primary care clinicians and referral to secondary care. Acute pain-related temporomandibular disorder (TMD) may be managed in the primary care setting, with identification of those at risk of developing chronic TMD receiving an early referral to secondary care...
December 2017: British Dental Journal
https://www.readbyqxmd.com/read/29074312/understanding-the-patient-experience-with-carcinoid-syndrome-exit-interviews-from-a-randomized-placebo-controlled-study-of-telotristat-ethyl
#20
Lowell Anthony, Claire Ervin, Pablo Lapuerta, Matthew H Kulke, Pamela Kunz, Emily Bergsland, Dieter Hörsch, David C Metz, Janice Pasieka, Nick Pavlakis, Marianne Pavel, Martyn Caplin, Kjell Öberg, John Ramage, Emily Evans, Qi Melissa Yang, Shanna Jackson, Karie Arnold, Linda Law, Dana B DiBenedetti
PURPOSE: Telotristat ethyl, an oral tryptophan hydroxylase inhibitor, is intended to treat carcinoid syndrome by reducing serotonin production. Telotristat ethyl was evaluated in TELESTAR, a Phase III study for patients who had carcinoid syndrome with at least 4 bowel movements (BMs) per day and who were receiving somatostatin analogue therapy. This interview substudy was conducted to provide insight into the patient experience in TELESTAR and to help understand whether reductions in BM frequency (the primary end point) and other symptoms were clinically meaningful...
October 23, 2017: Clinical Therapeutics
keyword
keyword
104376
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"