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https://www.readbyqxmd.com/read/28548144/metal-free-spin-and-spin-gapless-semiconducting-heterobilayers-monolayer-boron-carbonitrides-on-hexagonal-boron-nitride
#1
Hongzhe Pan, Hongyu Zhang, Yuanyuan Sun, Yingchun Ding, Jie Chen, Youwei Du, Nujiang Tang
The interfaces between monolayer boron carbonitrides and hexagonal boron nitride (h-BN) play an important role in their practical applications. Herein, we respectively investigate the structural and electronic properties of two metal-free heterobilayers constructed by vertically stacking two-dimensional (2D) spintronic materials (B4CN3 and B3CN4) on a h-BN monolayer from the viewpoints of lattice match and lattice mismatch models using density functional calculations. It is found that both B4CN3 and B3CN4 monolayers can be stably adsorbed on the h-BN monolayer due to the van der Waals interactions...
May 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28544361/drug-coated-balloons-for-the-treatment-of-in-stent-restenosis-in-diabetic-patients-a-review-of-currently-available-scientific-data
#2
Alberto Minacapelli, Davide Piraino, Dario Buccheri, Bernardo Cortese
After the introduction of drug eluting stent (DES) the rate of in-stent restenosis (ISR) has decreased if compared to the BMS era; however, treatment of patients with ISR remained a major issue for the interventional cardiologist. DES has been largely used with good results also as second layer for the treatment of ISR, but the overall percentage of patients suffering from restenosis still remains high, especially in some subgroups of patients as ones with diabetes mellitus (DM). In this clinical scenario, drug coated balloon (DCB) has been gaining an important role for the treatment of ISR...
May 22, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28537398/discovery-of-clinical-candidate-2-2s-6s-2-phenyl-6-hydroxyadamantan-2-yl-1-3-hydroxyazetidin-1-yl-ethanone-bms-816336-an-orally-active-novel-selective-11%C3%AE-hydroxysteroid-dehydrogenase-type-1-inhibitor
#3
Xiang-Yang Ye, Stephanie Y Chen, Shung Wu, David S Yoon, Haixia Wang, Zhenqiu Hong, Stepen P O'Connor, Jun Li, James J Li, Lawrence L Kennedy, Steven J Walker, Akbar Nayeem, Steven Sheriff, Daniel M Camac, Vidyhashankar Ramamurthy, Paul E Morin, Rachel Zebo, Joseph R Taylor, Nathan N Morgan, Randolph P Ponticiello, Thomas Harrity, Atsu Apedo, Rajasree Golla, Ramakrishna Seethala, Mengmeng Wang, Timothy W Harper, Bogdan G Sleczka, Bin He, Mark Kirby, David K Leahy, Jianqing Li, Ronald L Hanson, Zhiwei Guo, Yi-Xin Li, John D DiMarco, Raymond Scaringe, Brad D Maxwell, Frederick Moulin, Joel C Barrish, David A Gordon, Jeffrey A Robl
BMS-816336 (6n-2), a hydroxyl-substituted adamantyl acetamide, has been identified as a novel, potent inhibitor against human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme (IC50 3.0 nM) with >10000 fold selectivity over human 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). BMS-816336 exhibits a robust acute pharmacodynamic effects in cynomolgus monkeys (ED50 0.13 mpk) and in DIO mice. It is orally bioavailable (%F ranges from 20-72% in preclinical species) and has a predicted pharmacokinetic profile of a high peak to trough ratio and short half-life in humans...
May 24, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28534603/biomarkers-for-psoriasis-skin-lesions
#4
Angelo M D'Erme, Francesca Papadia, Joerg Wenzel, Thomas Bieber, Marco Romanelli, Andrea Chiricozzi
Psoriasis is a common, chronic skin disease, whose diagnosis is based mainly on clinical features but, in some cases, can be difficult. As the exact diagnosis of psoriasis and the differential diagnosis with other diseases is crucial for the diagnosis and the therapeutic choice, several studies investigated the relevance of some genes and proteins as potential specific skin biomarkers. Despite a large number of studies, none of them has been tested in large studies and thus achieved regulatory approval and clinical application...
May 23, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28530331/-burning-mouth-syndrome-a-flame-hard-to-extinguish
#5
REVIEW
Mordechai Findler, Eli Michaeli, Yaron Haviv
Burning mouth syndrome (BMS) is a common condition that mostly affects elderly women. This symptom presents as a severe chronic burning sensation affecting the oral cavity and especially the dorsum of the tongue and its lateral aspects. Mouth burning sensation can result from an idiopathic primary condition or evolve from a secondary problem. The difficulty in reaching a correct diagnosis and especially to determining an appropriate treatment leads to considerable dissatisfaction among patients. In this paper we review the causes and the characteristics of the primary and secondary forms of the syndrome, the means of diagnosis and known treatment options...
August 2016: Harefuah
https://www.readbyqxmd.com/read/28529095/understanding-operator-stent-choice-in-the-catheterization-laboratory-using-a-pre-procedure-survey-opportunities-for-quality-improvement
#6
Matthew J Chung, Jonathan D Hansen, Ryan D Schulteis, Joel C Boggan, W Schuyler Jones, Thomas J Povsic, Susan Roberts, Mitchell W Krucoff, Sunil V Rao
OBJECTIVES: We sought to characterize how the perceived risk of early dual antiplatelet therapy (DAPT) discontinuation is incorporated into operator decision-making regarding stent choice, using a simple pre-procedure survey screening for clinical variables that may lead to early DAPT discontinuation. BACKGROUND: Understanding which factors influence operator decision-making regarding stent choice during percutaneous coronary intervention (PCI) could help identify areas for quality improvement...
May 8, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28503977/emerging-treatments-for-ulcerative-colitis-a-systematic-review
#7
Damianos G Kokkinidis, Eftychia E Bosdelekidou, Sotiria Maria Iliopoulou, Alexandros G Tassos, Pavlos T Texakalidis, Konstantinos P Economopoulos, Antonis A Kousoulis
OBJECTIVES: Various investigational medicinal products have been developed for ulcerative colitis (UC). Our aim was to systematically evaluate novel pharmacological therapeutic agents for the treatment of UC. MATERIAL AND METHODS: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations were followed. A search of the medical literature was conducted in the MEDLINE database for original research papers published between 01 January 2010 and 31 October 2014...
May 14, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28498399/dual-inhibition-of-igf1r-and-er-enhances-response-to-trastuzumab-in-her2-positive-breast-cancer-cells
#8
Martina S J McDermott, Alexandra Canonici, Laura Ivers, Brigid C Browne, Stephen F Madden, Neil A O'Brien, John Crown, Norma O'Donovan
Although HER2 targeted therapies have improved prognosis for HER2 positive breast cancer, HER2 positive cancers which co-express ER have poorer response rates to standard HER2 targeted therapies, combined with chemotherapy, than HER2 positive/ER negative breast cancer. Administration of hormone therapy concurrently with chemotherapy and HER2 targeted therapy is generally not recommended. Using publically available gene expression datasets we found that high expression of IGF1R is associated with shorter disease-free survival in patients whose tumors are ER positive and HER2 positive...
April 26, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28489156/impact-of-free-thyroxine-levels-and-other-clinical-factors-on-bare-metal-stent-restenosis
#9
Uğur Canpolat, Osman Turak, Fırat Özcan, Fatih Öksüz, Mehmet Ali Mendi, Çağrı Yayla, Sinan Aydoğdu
Objective: Thyroid hormones have both direct and indirect effects on thermogenesis such as modulating vascular smooth muscle cell proliferation. However, the influence of more subtle changes in thyroid hormones on coronary atherosclerosis remains a matter of speculation. Smooth muscle cells play a crucial role in the pathogenesis of in-stent restenosis (ISR). However, the relationship between free thyroxine (fT4) and ISR has not been studied. In the present study, we aimed to assess the role of preprocedural serum fT4 level on the development of ISR in patients undergoing coronary bare metal stent (BMS) implantation...
March 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28488405/dollars-and-stents-a-brave-new-world
#10
EDITORIAL
Sandeep K Krishnan, Larry S Dean
Reimbursement in the healthcare system is shifting from pure volume to a mixed volume/value-based metric. Using complex statistical modeling to adjust for unknowns, the study provides real world data that the use of Co-Cr EES is more cost effective than BMS assuming that clinicians select clopidogrel for P2Y12 inhibition. More cost-effectiveness analyses should be conducted to guide the use of ever costlier novel medical devices and drugs.
May 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28487283/bile-acids-deoxycholic-acid-and-ursodeoxycholic-acid-differentially-regulate-human-%C3%AE-defensin-1-and-2-secretion-by-colonic-epithelial-cells
#11
Natalia K Lajczak, Vinciane Saint-Criq, Aoife M O'Dwyer, Alessia Perino, Luciano Adorini, Kristina Schoonjans, Stephen J Keely
Bile acids and epithelial-derived human β-defensins (HβDs) are known to be important factors in the regulation of colonic mucosal barrier function and inflammation. We hypothesized that bile acids regulate colonic HβD expression and aimed to test this by investigating the effects of deoxycholic acid (DCA) and ursodeoxycholic acid on the expression and release of HβD1 and HβD2 from colonic epithelial cells and mucosal tissues. DCA (10-150 µM) stimulated the release of both HβD1 and HβD2 from epithelial cell monolayers and human colonic mucosal tissue in vitro In contrast, ursodeoxycholic acid (50-200 µM) inhibited both basal and DCA-induced defensin release...
May 9, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28487112/outcomes-of-self-expanding-ptfe-covered-stent-versus-bare-metal-stent-for-chronic-iliac-artery-occlusion-in-matched-cohorts-using-propensity-score-modelling
#12
M Piazza, F Squizzato, A Dall'Antonia, S Lepidi, M Menegolo, F Grego, M Antonello
OBJECTIVES: The aim was to compare outcomes of self expanding PTFE covered stents (CSs) with bare metal stents (BMSs) in the treatment of iliac artery occlusions (IAOs). METHODS: Between January 2009 and December 2015, 128 iliac arteries were stented for IAO. A CS was implanted in 78 iliac arteries (61%) and a BMS in 50 (49%). After propensity score matching, 94 limbs were selected and underwent stenting (47 for each group). Thirty day outcomes and midterm patency were compared; follow-up results were analysed with Kaplan-Meier curves...
May 6, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28485182/a-quantitative-angiographic-comparison-of-restenotic-tissue-following-placement-of-drug-eluting-stents-and-bare-metal-stents-in-symptomatic-patients-with-femoropopliteal-disease
#13
Gary M Ansel, Michael R Jaff, Jeffrey J Popma, Anthony J Battisti, Aaron E Lottes, Paul Harnish, Michael D Dake
PURPOSE: To evaluate the patterns of in-stent restenosis (ISR) within femoropopliteal bare metal stents (BMS) and drug-eluting stents (DES) as determined by quantitative angiographic analysis. METHODS: Utilizing results from independent core laboratory angiographic imaging analysis, quantitative assessment of the restenotic tissue burden was evaluated in 33 patients with symptomatic femoropopliteal ISR, including 20 lesions in 19 patients (mean age 71.5±8.1 years; 11 men) treated with DES and 14 lesions in 14 patients (mean age 70...
May 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28485052/evaluation-of-the-thermal-property-of-bovine-intramuscular-adipose-tissue-using-differential-scanning-calorimetry
#14
Noriyuki Kimura, Nana Nishimura, Nagako Iwama, Yoshito Aihara, Yasuki Ogawa, Yuji Miyaguchi
The thermal property of bovine intramuscular adipose tissue (IAT) was evaluated using differential scanning calorimetry (DSC) and compared with the melting point temperature (MP) of the fat extract of IAT, which was measured using the slip point method. The beef samples were classified according to the beef marbling score (BMS). Beef with a high BMS contained less protein than that with middle or low BMS. Beef with a high BMS contained significantly more fat than that with a low BMS (P < 0.05). The endothermic point temperature (EP) of IAT, measured by DSC, was significantly higher than the MP of IAT fat (P < 0...
May 8, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28484288/association-between-vegf-gene-polymorphisms-and-in-stent-restenosis-after-coronary-intervention-treated-with-bare-metal-stent
#15
Zsolt Bagyura, Loretta Kiss, Kristóf Hirschberg, Balázs Berta, Gábor Széplaki, Árpád Lux, Zsolt Szelid, Pál Soós, Béla Merkely
Background. In-stent restenosis (ISR) is the gradual narrowing of the vessel lumen after coronary stent implantation due to the increase in vascular smooth muscle cell proliferation. Vascular endothelial growth factor (VEGF) protein plays an important role in this process. Our aim was to analyze the association of single nucleotide polymorphisms of the VEGF gene (rs2010963 and rs6999447) with the occurrence of ISR after coronary artery bare metal stent (BMS) implantation. Methods. 205 patients with a history of BMS implantation and a repeated coronarography were prospectively enrolled...
2017: Disease Markers
https://www.readbyqxmd.com/read/28483656/two-year-gender-differences-in-satisfaction-with-appearance-after-burn-injury-and-prediction-of-five-year-depression-a-latent-growth-curve-approach
#16
Nour Al Ghriwati, Megan Sutter, Bradford S Pierce, Paul B Perrin, Shelley A Wiechman, Jeffrey C Schneider
OBJECTIVE: To use latent growth curve and longitudinal structural equation modeling to examine the two-year trajectory of satisfaction with appearance in adults with burn injury and that trajectory's effect on depression five years after burn injury. DESIGN: Data were collected at discharge after burn injury hospitalization, six months, one year, two years, and five years post-discharge. SETTING: The Burn Model System (BMS) program consisted of a data center and five participating burn centers...
May 5, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28480650/comparison-of-drug-eluting-balloon-followed-by-bare-metal-stent-with-drug-eluting-stent-for-treatment-of-de-novo-lesions-randomized-controlled-single-center-clinical-trial
#17
In Ho Chae, Chang Hwan Yoon, Jin Joo Park, Il Young Oh, Jung Won Suh, Young Seok Cho, Tae Jin Youn, Dong Ju Choi
The combined use of a drug-eluting balloon (DEB) and a bare metal stent (BMS) for the treatment of de novo non-small vessel coronary artery diseases (CAD) remains to be evaluated. We investigated the efficacy of a sequential treatment using a DEB together with a BMS implantation in comparison to a zotarolimus-eluting stent (ZES). This study was a prospective, randomized, open-label study. We designed it to demonstrate the non-inferiority of a sequential treatment using a DEB first followed by a BMS (DEB + BMS) compared with the use of a ZES...
June 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28479462/iliac-artery-stenting-combined-with-ipsilateral-open-femoro-popliteal-revascularization-and-its-effect-on-bypass-patency
#18
Michele Piazza, Francesco Squizzato, Sandro Lepidi, Mirko Menegolo, Franco Grego, Michele Antonello
OBJECTIVES: In cases of multilevel obstructive atherosclerotic disease, hybrid procedures of concomitant iliac artery stenting and femoro-popliteal bypass (IS-FPB) may represent a valid approach, but results are still unclear. The aim was to evaluate early and long-term outcomes of concurrent IS-FPB. METHODS: This retrospective study included 75 patients (76 limbs) treated with concomitant IS-FPB between January 2010 and June 2016. All patients were prospectively enrolled in a dedicated database...
May 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28473243/pain-relieving-effects-of-clonazepam-and-amitriptyline-in-burning-mouth-syndrome-a-retrospective-study
#19
M Fenelon, E Quinque, E Arrive, S Catros, J C Fricain
This retrospective study aimed to evaluate the efficacy of clonazepam and amitriptyline in the treatment of burning mouth syndrome (BMS). A single-centre retrospective cohort study was performed among patients diagnosed with BMS. Either clonazepam or amitriptyline was administered. Patients were asked to evaluate their pain using a 10-point verbal numerical scale (VNS) at baseline, and at 6 weeks and 3 months of treatment. Mean pain-relief values were assessed according to the treatment received using the Kruskal-Wallis test...
May 1, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28455207/role-of-regional-absorption-and-gastrointestinal-motility-on-variability-in-oral-drug-absorption-of-a-model-drug
#20
Ajit S Narang, Anand Balakrishnan, John Morrison, Jinjiang Li, Jennifer Wang, Huidong Gu, Katrina Taylor, Kenneth Santone, Jon Ehrmann, Sophie Beyer, Xujin Lu, Rod Ketner, Jennifer Pizzano, Tami Orcutt, Eric Shields, Heidi Dulac, Sharon Aborn, Margaret Batchelder, Kimberley Lentz
Variability in oral absorption in pre-clinical species makes human dose projection challenging. In this study, we investigated the mechanistic basis of variability in oral absorption of a model hydrophobic compound with pH-dependent solubility, BMS-955829, after oral dosing in rats, dogs, and cynomolgus monkeys. The contribution of regional absorption to pharmacokinetic variability was assessed in ported monkeys by direct drug intraduodenal and intraileal administration. The effect of BMS-955829 on gastric emptying and intestinal motility was investigated by radiography after co-administration of barium...
April 25, 2017: European Journal of Pharmaceutics and Biopharmaceutics
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