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https://www.readbyqxmd.com/read/28938529/defining-a-therapeutic-window-for-kinase-inhibitors-in-leukemia-to-avoid-neutropenia
#1
Kate McArthur, Akshay A D'Cruz, David Segal, Kurt Lackovic, Andrew F Wilks, Joanne A O'Donnell, Cameron J Nowell, Motti Gerlic, David C S Huang, Christopher J Burns, Ben A Croker
Neutropenia represents one of the major dose-limiting toxicities of many current cancer therapies. To circumvent the off-target effects of cytotoxic chemotherapeutics, kinase inhibitors are increasingly being used as an adjunct therapy to target leukemia. In this study, we conducted a screen of leukemic cell lines in parallel with primary neutrophils to identify kinase inhibitors with the capacity to induce apoptosis of myeloid and lymphoid cell lines whilst sparing primary mouse and human neutrophils. We have utilized a high-throughput live cell imaging platform to demonstrate that cytotoxic drugs have limited effects on neutrophil viability but are toxic to hematopoietic progenitor cells, with the exception of the topoisomerase I inhibitor SN-38...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28935472/treatment-of-superficial-femoral-artery%C3%A2-restenosis
#2
Andrew J Miller, Edwin A Takahashi, William S Harmsen, Kristin C Mara, Sanjay Misra
PURPOSE: To determine the predictors of restenosis, major adverse limb events (MALEs), postoperative death (POD), and all-cause mortality after repeat endovascular treatment of superficial femoral artery (SFA) restenosis. MATERIALS AND METHODS: This was a retrospective review of 440 patients with 518 SFA lesions who were treated between January 2002 and October 2011. Ninety-six limbs were treated for restenosis with bare metal stents (BMSs) or percutaneous transluminal angioplasty (PTA), of which 28 limbs developed another restenosis requiring a third procedure...
September 19, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28932557/correlation-between-egfr-mutation-status-and-the-incidence-of-brain-metastases-in-patients-with-non-small-cell-lung-cancer
#3
Lina Li, Shuimei Luo, Heng Lin, Haitao Yang, Huijuan Chen, Ziyuan Liao, Wanzun Lin, Weili Zheng, Xianhe Xie
BACKGROUND: Lung cancer is the leading cause of cancer-related death worldwide. Numerous studies have been performed to investigate the correlation between epidermal growth factor receptor (EGFR) mutation status and the incidence of brain metastases (BMs) in patients with non-small cell lung cancer (NSCLC), however, the outcomes were inconsistent. Thus, we performed this study to establish the role of EGFR mutation status in BMs. METHODS: Electronic databases PubMed, Embase, Cochrane Library, CBM, WanFang, CNKI were searched to identify relevant trials...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28931359/bms-statement-on-custom-compounded-bioidentical-hormones
#4
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Post Reproductive Health
https://www.readbyqxmd.com/read/28930758/changes-in-basic-movement-ability-and-activities-of-daily-living-after-hip-fractures-correlation-between-basic-movement-scale-and-motor-functional-independence-measure-scores
#5
Shogo Toyama, Koshiro Sawada, Keiichiro Ueshima, Yasuo Mikami, Isamu Mori, Kiyoshi Takamuku, Tai Takahashi, Toshikazu Kubo
OBJECTIVE: The aim of this study was to examine the correlation between basic movement ability and activities of daily living (ADL) in elderly patients after hip fracture surgery and predict ADL outcomes from changes in basic movement ability. DESIGN: Fifty-four patients receiving rehabilitation after hip fracture surgery were collected prospectively. Ambulatory ability was evaluated using a Basic Movement Scale (BMS), and ADL was evaluated using the motor subscale of the Functional Independence Measure (motor-FIM)...
September 19, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28916026/a-diagnostic-and-therapeutic-approach-to-primary-burning-mouth-syndrome
#6
Siamak Moghadam-Kia, Nasim Fazel
Primary burning mouth syndrome (BMS) is an oral mucosal disorder that is characterized by a chronic and often debilitating intraoral burning sensation for which no localized or systemic cause can be found. BMS most commonly affects postmenopausal women. The pathophysiology of primary BMS is not well understood. Diagnosing BMS can prove to be challenging. BMS patients can also pose a therapeutic challenge to clinicians who are consulted to evaluate these patients. Most commonly used therapies include tricyclic antidepressants, α-lipoic acid, clonazepam, and cognitive-behavioral therapy...
September 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28915686/evaluation-on-efficacy-and-safety-of-the-addition-of-x-knife-therapy-to-gefitinib-in-nsclc-patients-with-symptomatic-brain-metastases
#7
Linbo Cai, Xiaoguang Qiu, Haihong Yang, Mingyao Lai, Changguo Shan, Weiping Hong, Juan Li, Longhui Luo, Ping Zhang, Lichao Wang
BACKGROUND: Stereotactic radiosurgery (SRS) is a widely used therapy for brain metastases(BMs) in Non-small cell lung cancer(NSCLC). However, its role in symptomatic patients with EGFR mutation remains unclear. We have retrospectively reviewed the clinical data of patients with symptomatic BMs whom received SRS as a salvage approach and concurrent gifitinib therapy. METHODS: Seven patients with primary NSCLC, symptomatic BMs, and EGFR mutation were identified in a retrospective review of patients treated with SRS using X-knife at Guangdong 999 Brain Hospital between 1 January 2012 and 31 August 2014...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915510/drug-eluting-vs-bare-metal-stents-in-patients-with-chronic-kidney-disease-and-coronary-artery-disease-insights-from-a-systematic-review-and-meta-analysis
#8
Alexander Volodarskiy, Sunil Kumar, Radoslaw Pracon, Mandeep Sidhu, Evgeny Kretov, Tomasz Mazurek, Olga Bockeria, Upendra Kaul, Sripal Bangalore
BACKGROUND: Most drug-eluting stent (DES) trials have excluded patients with chronic kidney disease (CKD). The efficacy of DES implantation in patients with CKD is therefore not known. OBJECTIVES: To evaluate the outcomes with DES vs bare-metal stent (BMS) implantation in patients with CKD. METHODS AND RESULTS: MEDLINE, EMBASE, and CENTRAL were searched for studies including at least 100 patients with CKD (estimated glomerular filtration rate ≤60 mL/min/1...
September 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28913600/a-multilayer-biomaterial-for-osteochondral-regeneration-shows-superiority-vs-microfractures-for-the-treatment-of-osteochondral-lesions-in-a-multicentre-randomized-trial-at-2-years
#9
Elizaveta Kon, Giuseppe Filardo, Mats Brittberg, Maurizio Busacca, Vincenzo Condello, Lars Engebretsen, Stefan Marlovits, Philipp Niemeyer, Patrik Platzer, Michael Posthumus, Peter Verdonk, Renè Verdonk, Jan Victor, Willem van der Merwe, Wojciech Widuchowski, Claudio Zorzi, Maurilio Marcacci
PURPOSE: The increasing awareness on the role of subchondral bone in the etiopathology of articular surface lesions led to the development of osteochondral scaffolds. While safety and promising results have been suggested, there are no trials proving the real potential of the osteochondral regenerative approach. Aim was to assess the benefit provided by a nanostructured collagen-hydroxyapatite (coll-HA) multilayer scaffold for the treatment of chondral and osteochondral knee lesions. METHODS: In this multicentre randomized controlled clinical trial, 100 patients affected by symptomatic chondral and osteochondral lesions were treated and evaluated for up to 2 years (51 study group and 49 control group)...
September 14, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28904298/usefulness-of-urinary-biomarkers-for-nephrotoxicity-in-cynomolgus-monkeys-treated-with-gentamicin-cisplatin-and-puromycin-aminonucleoside
#10
Hiroshi Uchino, Junko Fujishima, Kaori Fukuoka, Teppei Iwakiri, Akira Kamikuri, Hidenori Maeda, Kazuhiro Nakama
The objective of this study was to investigate the availability of novel urinary biomarkers (BMs) such as total protein, albumin, β2-microglobulin, clusterin, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL) for the detection of acute nephrotoxicity in cynomolgus monkeys. Animals (total 9 males/3 groups) were administered gentamicin (GM) subcutaneously at 40 mg/kg for 7 days, cisplatin (CDDP) intravenously at 3 mg/kg once and puromycin aminonucleoside (PAN) intravenously at 20 mg/kg for 7 days...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28895026/growth-arrest-specific-protein-7-regulates-the-murine-m1-alveolar-macrophage-polarization
#11
Qian Xu, Xiaofan Liu, Xinyuan Wang, Yuanqi Hua, Xiaoying Wang, Junli Chen, Jingyu Li, Yi Wang, Tobias Stoeger, Shanze Chen, Ning Huang
Growth arrest-specific gene 7 (Gas7) is preferentially expressed in terminally differentiated brain cells and plays a crucial role during neuronal development and neurite outgrowth. Apart from that, Gas7 was found to be abundantly expressed in immune cells like murine macrophage without knowing the actual roles in immune reaction. By using the Illumina microarray analysis, we observed a clear induction of Gas7 but no other Gas family members in murine M1-polarized alveolar macrophage, which was further confirmed by RT-qPCR, Western blotting, and immunostaining analysis, suggesting a likelihood that Gas7 may participate in murine alveolar macrophage polarization...
September 11, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28891471/polymer-free-drug-coated-coronary-stents-are-cost-effective-in-patients-at-high-bleeding-risk-economic-evaluation-of-the-leaders-free-trial
#12
Antoine Filipovic-Pierucci, Isabelle Durand-Zaleski, Thibault Butel, Samantha Greene, Thomas Hovasse, Andres Iñiguez, Marco Stefano Nazzaro, Keith G Oldroyd, Suneel Talwar, Gert Richardt, Ute Windhovel, Philip Urban, Marie-Claude Morice
AIMS: In patients at high risk of bleeding who undergo PCI the biolimus A9 polymer-free drug coated stent (DCS) has superior efficacy and safety compared to a bare metal stent (BMS). We estimated the cost effectiveness of DCS vs. BMS. METHODS AND RESULTS: The Leaders FREE-based economic evaluation estimated service use and quality of life data collected prospectively. The entire trial population was analysed using cost-weights from England, France, Germany, Italy, Scotland and Spain...
September 12, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28888408/atrial-fibrillation-and-stent-selection-bare-metal-vs-drug-eluting-from-medicare-claims
#13
Greg Dadekian, Aaron V Kaplan, Chiang-Hua Chang, Nancy E Morden
In treating coronary artery disease, many factors influence the choice of bare metal stent (BMS) or drug-eluting stent (DES), including bleed risk and suitability for prolonged dual antiplatelet therapy. Atrial fibrillation (AF) further complicates this choice, due to common use of anticoagulation. We examined stent selection in the United States by AF status and across academic medical centers (AMCs) to explore how cardiologists are managing this complex choice. Using a 100% Medicare denominator file and associated claims (2008 to 2012), we identified patients over age 65 receiving inpatient coronary artery stents...
August 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28886701/the-loss-of-function-disease-mutation-g301r-in-the-na-k-atpase-%C3%AE-2-isoform-decreases-lesion-volume-and-improves-functional-outcome-after-acute-spinal-cord-injury-in-mice
#14
Ditte Gry Ellman, Toke Jost Isaksen, Minna Christiansen Lund, Safinaz Dursun, Martin Wirenfeldt, Louise Helskov Jørgensen, Karin Lykke-Hartmann, Kate Lykke Lambertsen
BACKGROUND: The Na(+)/K(+)-ATPases are transmembrane ion pumps important for maintenance of ion gradients across the plasma membrane that serve to support multiple cellular functions, such as membrane potentials, regulation of cellular volume and pH, and co-transport of signaling transmitters in all animal cells. The α2Na(+)/K(+)-ATPase subunit isoform is predominantly expressed in astrocytes, which us the sharp Na(+)-gradient maintained by the sodium pump necessary for astroglial metabolism...
September 8, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28884860/pharmacological-treatment-of-oro-facial-pain-health-technology-assessment-including-a-systematic-review-with-network-meta-analysis
#15
REVIEW
B Häggman-Henrikson, P Alstergren, T Davidson, E D Högestätt, P Östlund, S Tranaeus, S Vitols, T List
This health technology assessment evaluated the efficacy of pharmacological treatment in patients with oro-facial pain. Randomised controlled trials were included if they reported pharmacological treatment in patients ≥18 years with chronic (≥3 months) oro-facial pain. Patients were divided into subgroups: TMD-muscle [temporomandibular disorders (TMD) mainly associated with myalgia]; TMD-joint (TMD mainly associated with temporomandibular joint pain); and burning mouth syndrome (BMS). The primary outcome was pain intensity reduction after pharmacological treatment...
October 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28877441/development-of-large-scale-synthesis-of-tetrahydropyran-glycine-a-precursor-to-the-hcv-ns5a-inhibitor-bms-986097
#16
Arvind Mathur, Bei Wang, Daniel Smith, Jianqing Li, Joseph Pawluczyk, Jung-Hui Sun, Michael Kwok Wong, Subramaniam Krishnananthan, Dauh-Rurng Wu, Dawn Sun, Peng Li, Shiuhang Yip, Bang-Chi Cheng, Phil S Baran, Qi Chen, Omar D Lopez, Zhong Yong, John A Bender, Van N Nguyen, Jeffrey L Romine, Denis R St Laurent, Gan Wang, John F Kadow, Nicholas A Meanwell, Makonen Belema, Rulin Zhao
An efficient large scale synthesis of acid 1, a penultimate precursor to the HCV NS5A inhibitor BMS-986097, along with the final API step are described. Three routes were devised for the synthesis of 1 at the various stages of the program. The 3rd generation route, the one that proved scalable and is the main subject of this manuscript, features a one step Michael addition of t-butyl 2-((diphenylmethylene)amino)acetate 24 to (E)-benzyl 4-(1-hydroxycyclopropyl)but-2-enoate 28 followed by cyclization and chiral separation to form 27c, the core skeleton of cap piece 1...
September 6, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28871997/single-fraction-stereotactic-radiosurgery-srs-alone-versus-surgical-resection-and-srs-for-large-brain-metastases-a-multi-institutional-analysis
#17
Roshan S Prabhu, Robert H Press, Kirtesh R Patel, Danielle M Boselli, James T Symanowski, Scott P Lankford, Robert J McCammon, Benjamin J Moeller, John H Heinzerling, Carolina E Fasola, Anthony L Asher, Ashley L Sumrall, Zachary S Buchwald, Walter J Curran, Hui-Kuo G Shu, Ian Crocker, Stuart H Burri
PURPOSE: Stereotactic radiosurgery (SRS) dose is limited by brain metastasis (BM) size. The study goal was to retrospectively determine whether there is a benefit for intracranial outcomes and overall survival (OS) for gross total resection with single-fraction SRS versus SRS alone for patients with large BMs. METHODS AND MATERIALS: A large BM was defined as ≥4 cm(3) (2 cm in diameter) prior to the study. We reviewed the records of consecutive patients treated with single-fraction SRS alone or surgery with preoperative or postoperative SRS between 2005 and 2013 from 2 institutions...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28870640/ivus-findings-in-late-and-very-late-stent-thrombosis-a-comparison-between-bare-metal-and-drug-eluting-stents
#18
Lara Fuentes, Josep Gómez-Lara, Neus Salvatella, Nieves Gonzalo, Felipe Hernández-Hernández, Eduard Fernández-Nofrerias, Ángel Sánchez-Recalde, Fernando Alfonso, Rafael Romaguera, José Luis Ferreiro, Gerard Roura, Luis Teruel, Montserrat Gracida, Ana Lucrecia Marcano, Joan-Antoni Gómez-Hospital, Ángel Cequier
INTRODUCTION AND OBJECTIVES: Stent thrombosis (ST) is a life-threatening complication after stent implantation. Intravascular ultrasound is able to discern most causes of ST. The aim of this study was to compare intravascular ultrasound findings between bare-metal stents (BMS) and drug-eluting stents (DES) in patients with late (31 days to 1 year) or very late ST (> 1 year). METHODS: Of 250 consecutive patients with late or very late ST in 7 Spanish institutions, 114 patients (45...
September 1, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28866036/bioresorbable-vascular-scaffolds-for-patients-with-in-stent-restenosis-the-ribs-vi-study
#19
Fernando Alfonso, Javier Cuesta, María José Pérez-Vizcayno, Bruno García Del Blanco, José Ramón Rumoroso, Francisco Bosa, Armando Pérez de Prado, Mónica Masotti, Raul Moreno, Angel Cequier, Hipólito Gutiérrez, Arturo García Touchard, José Ramón López-Mínguez, Javier Zueco, Vicens Martí, Maite Velázquez, César Morís, Teresa Bastante, Marcos García-Guimaraes, Fernando Rivero, Cristina Fernández
OBJECTIVES: This study sought to assess the value of bioresorbable vascular scaffolds (BVS) in patients with in-stent restenosis (ISR). BACKGROUND: Currently both drug-eluting stents (DES) and drug-eluting balloons (DEB) are recommended in patients with ISR. However, the value of BVS in this setting remains unclear. METHODS: RIBS VI was a prospective multicenter study (19 Spanish sites) that included 141 patients treated with BVS for either bare-metal stent (BMS) ISR or DES-ISR...
August 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28865897/bare-metal-versus-drug-eluting-stents-for-st-segment-elevation-myocardial-infarction-in-the-total-trial
#20
Shahar Lavi, Javaid Iqbal, John A Cairns, Warren J Cantor, Asim N Cheema, Raul Moreno, Brandi Meeks, Robert C Welsh, Sasko Kedev, Saqib Chowdhary, Goran Stankovic, J D Schwalm, Yan Liu, Sanjit S Jolly, Vladimír Džavík
BACKGROUND: The safety and efficacy of drug eluting stents (DES) in the setting of ST elevation myocardial infarction (STEMI) is not well established. METHODS: In the TOTAL trial, patients presenting with STEMI were randomized to routine thrombectomy versus PCI alone. In this post-hoc analysis, propensity matching was used to assess relative safety and efficacy according to type of stent used. RESULTS: Each propensity-matched cohort included 2313 patients...
June 29, 2017: International Journal of Cardiology
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