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https://www.readbyqxmd.com/read/28440189/better-predictive-value-of-cancer-antigen125-ca125-as-biomarker-in-ovary-and-breast-tumors-and-its-correlation-with-the-histopathological-type-grade-of-the-disease
#1
Aarifa Nazmeen, Smarajit Maiti, Kusumita Mandal, Samir K Roy, Tamal Kanti Ghosh, Nirmalya K Sinha, Kamalika Mandal
BACKGROUND: Both ovarian/breast cancers are the most prevalent hormone-associated gynecological-cancers, where uncontrolled cellular proliferations/genetic-errors are noticed. The cancer-antigen125 (CA125), which we assessed presently is an important biomarker in the early detection/monitoring of this disease-pathogenesis. METHODS: Serum/tissue CA125 was measured by solid-phase-Enzyme-linked-immunosorbent-assay in women with ovarian/breast tumors of different types (epithelial/non-epithelial; benign/borderline/malignant)/stages...
April 24, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28439706/cks1bp7-a-pseudogene-of-cks1b-is-co-amplified-with-igf1r-in-breast-cancers
#2
Yansong Liu, Wei Wang, Yan Li, Feifei Sun, Jiaxiang Lin, Li Li
Pseudogenes have been reported to exhibit functional roles. Amplification or overexpression of CDC28 protein kinase regulatory subunit 1B (CKS1B) was found in various human cancers. But it was known little about CKS1B pseudogene 7 (CKS1BP7), a pseudogene sharing considerable sequence identity with CKS1B. The aim of this study was to evaluate copy number alterations (CNAs) of CKS1BP7 and address its potential roles in breast cancer. We detected copy numbers of CKS1BP7 and insulin-like growth factor 1 receptor (IGF1R) using quantitative multi-gene fluorescence in situ hybridization (QM-FISH) technique, compared their status in both invasive carcinoma and ductal carcinoma in situ (DCIS) components within the same tumors, and investigated the associations of CNAs with tumor features and patients outcomes...
April 24, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28430808/quantification-of-hypoxia-related-gene-expression-as-a-potential-approach-for-clinical-outcome-prediction-in-breast-cancer
#3
Abderrahim El Guerrab, Anne Cayre, Fabrice Kwiatkowski, Maud Privat, Jean-Marc Rossignol, Fabrice Rossignol, Frédérique Penault-Llorca, Yves-Jean Bignon
Breast cancers are solid tumors frequently characterized by regions with low oxygen concentrations. Cellular adaptations to hypoxia are mainly determined by "hypoxia inducible factors" that mediate transcriptional modifications involved in drug resistance and tumor progression leading to metastasis and relapse occurrence. In this study, we investigated the prognostic value of hypoxia-related gene expression in breast cancer. A systematic review was conducted to select a set of 45 genes involved in hypoxia signaling pathways and breast tumor progression...
2017: PloS One
https://www.readbyqxmd.com/read/28428927/limitations-of-personalized-medicine-and-gene-assays-for-breast-cancer
#4
David Tiberi, Laura Masucci, Daniel Shedid, Isabelle Roy, Toni Vu, Erica Patocskai, André Robidoux, Philip Wong
Adjuvant systemic treatments reduce the risk of breast cancer recurrence following the local treatment of primary stage I-III breast cancers. For patients with hormone-positive breast cancers receiving hormonal therapy, the risk of distant recurrence is under 20% and therefore, many patients may potentially be spared of chemotherapy. Consequently, several molecular signatures based on gene expression were developed to better determine which breast cancer patients would benefit from chemotherapy. We present the case of a 62-year-old woman diagnosed with an early stage hormone receptor-positive breast cancer that was treated with a partial mastectomy...
March 17, 2017: Curēus
https://www.readbyqxmd.com/read/28428107/clinicopathologic-factors-associated-with-survival-in-patients-with-breast-cancer-brain-metastasis
#5
Rong Li, Kui Zhang, Gene P Siegal, Shi Wei
Brain metastasis from breast cancer generally represents a catastrophic event yet demonstrates substantial biological heterogeneity. There have been limited studies solely focusing on the prognosis of patients with such metastasis. In this study, we carried out a comprehensive analysis in 108 consecutive patients with breast cancer brain metastases between 1997 and 2012 to further define clinicopathologic factors associated with early onset of brain metastasis and survival outcomes after development of them...
April 17, 2017: Human Pathology
https://www.readbyqxmd.com/read/28427436/a-3d-in-vitro-model-of-the-human-breast-duct-a-method-to-unravel-myoepithelial-luminal-interactions-in-the-progression-of-breast-cancer
#6
Edward P Carter, James A Gopsill, Jennifer J Gomm, J Louise Jones, Richard P Grose
BACKGROUND: 3D modelling fulfils a critical role in research, allowing for complex cell behaviour and interactions to be studied in physiomimetic conditions. With tissue banks becoming established for a number of cancers, researchers now have access to primary patient cells, providing the perfect building blocks to recreate and interrogate intricate cellular systems in the laboratory. The ducts of the human breast are composed of an inner layer of luminal cells supported by an outer layer of myoepithelial cells...
April 21, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28425973/edim-tktl1-apo10-blood-test-an-innate-immune-system-based-liquid-biopsy-for-the-early-detection-characterization-and-targeted-treatment-of-cancer
#7
REVIEW
Johannes F Coy
Epitope detection in monocytes (EDIM) represents a liquid biopsy exploiting the innate immune system. Activated monocytes (macrophages) phagocytose unwanted cells/cell fragments from the whole body including solid tissues. As they return to the blood, macrophages can be used for a non-invasive detection of biomarkers, thereby providing high sensitivity and specificity, because the intracellular presence of biomarkers is due to an innate immune response. Flow cytometry analysis of blood enables the detection of macrophages and phagocytosed intracellular biomarkers...
April 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28422879/the-clinicopathological-features-of-second-primary-cancer-in-patients-with-prior-breast-cancer
#8
YiHui Liu, ChunHui Dong, Ling Chen
Nowadays, the risk of developing second primary cancers among women diagnosed with prior breast cancer represents a public health issue worldwide.Twenty-eight cases of the primary breast cancer with the multiple primary cancers (MPC) between 2008 and 2015 at our hospital were retrospectively analyzed in regards to age of patients, family history, interval time of the 2 cancers, and survival time of these patients.A total 28 cases were analyzed, at the mean age of 44.57 years at the diagnosis of the first primary cancer...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28420584/neuroendocrine-carcinoma-of-the-breast-with-endobronchial-metastases-and-syndrome-of-inappropriate-antidiuretic-hormone-secretion
#9
Anaum Maqsood, Thaer Khoury, Prasanna Kumar, Antonios Papanicolau-Sengos, Amy P Early
No abstract text is available yet for this article.
March 21, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28419815/diagnostic-performance-of-and-breast-tissue-changes-at-early-breast-mr-imaging-surveillance-in-women-after-breast-conservation-therapy
#10
Eun Jeong Kim, Bong Joo Kang, Sung Hun Kim, In Kyung Youn, Ji Eun Baek, Hyun Sil Lee
Purpose To investigate the diagnostic performance and tissue changes in early (1 year or less) breast magnetic resonance (MR) imaging surveillance in women who underwent breast conservation therapy for breast cancer. Materials and Methods This prospective study was approved by the institutional review board, and written informed consent was obtained. Between April 2014 and June 2016, 414 women (mean age, 51.5 years; range, 21-81 years) who underwent 422 early surveillance breast MR imaging examinations (median, 6...
April 18, 2017: Radiology
https://www.readbyqxmd.com/read/28418164/molecular-subtyping-of-mammary-like-adenocarcinoma-of-the-vulva-shows-molecular-similarity-to-breast-carcinomas
#11
Basile Tessier-Cloutier, Karama Asleh-Aburaya, Varsha Shah, W Glenn McCluggage, Anna Tinker, C Blake Gilks
AIMS: Mammary-like adenocarcinoma (MLA) of the vulva is thought to be derived from vulvar mammary-like glands. We characterized a series of MLA using an immunohistochemical algorithm that identifies the major molecular subtypes of breast cancer. METHODS AND RESULTS: Seven cases of vulval MLA were stained for ER, PR, HER2, Ki-67, EGFR, CK5, nestin and INPP4b. 17 cases of vulval extramammary Paget disease (EMPD), 7 with invasion, were studied for comparison. The median age of patients with MLA was 72 years...
April 18, 2017: Histopathology
https://www.readbyqxmd.com/read/28415667/effect-of-radiotherapy-after-breast-conserving-surgery-in-older-patients-with-early-breast-cancer-and-breast-ductal-carcinoma-in-situ-a-meta-analysis
#12
Xuan-Zhang Huang, You Chen, Wen-Jun Chen, Xi Zhang, Cong-Cong Wu, Chao-Ying Zhang, Shuang-Shuang Sun, Jian Wu
BACKGROUND: There are no consistent agreements on whether radiotherapy after breast-conserving surgery (BCS) could provide local control and survival benefit for older patients with early breast cancer or breast ductal carcinoma in situ (DCIS). The present study aimed to evaluate the efficacy of radiotherapy after BCS in older patients with early breast cancer or DCIS. RESULTS: Radiotherapy could reduce the risk of local relapse in older patients with early breast cancer...
March 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28405082/primary-small-cell-carcinoma-of-the-breast
#13
Benjamin Raber, Tuoc Dao, Evan Howard, Arthur Bredeweg
Early diagnosis of rare breast cancers is expected to occur more frequently as screening compliance improves and diagnostic modalities become more sensitive. Well-defined treatment algorithms exist for the management of ductal and lobular carcinomas; however, less information is available to guide the treatment of atypical breast cancers. This case report describes a 38-year-old African American woman with primary small cell carcinoma of the breast and her treatment.
April 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28402908/current-treatment-trends-and-the-need-for-better-predictive-tools-in-the-management-of-ductal-carcinoma-in-situ-of-the-breast
#14
REVIEW
Carlos Martínez-Pérez, Arran K Turnbull, Gregory E Ekatah, Laura M Arthur, Andrew H Sims, Jeremy S Thomas, J Michael Dixon
Ductal carcinoma in situ (DCIS) of the breast represents a group of heterogeneous non-invasive lesions the incidence of which has risen dramatically since the advent of mammography screening. In this review we summarise current treatment trends and up-to-date results from clinical trials studying surgery and adjuvant therapy alternatives, including the recent consensus on excision margin width and its role in decision-making for post-excision radiotherapy. The main challenge in the clinical management of DCIS continues to be the tailoring of treatment to individual risk, in order to avoid the over-treatment of low-risk lesions or under-treatment of DCIS with higher risk of recurring or progressing into invasion...
March 31, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28401771/preoperative-magnetic-resonance-imaging-in-patients-with-stage-i-invasive-ductal-breast-cancer-a-prospective-randomized-study
#15
N Brück, I Koskivuo, P Boström, J Saunavaara, R Aaltonen, R Parkkola
BACKGROUND AND AIMS: Preoperative magnetic resonance imaging has become an important complementary imaging technique in patients with breast cancer, providing additional information for preoperative local staging. Magnetic resonance imaging is recommended selectively in lobular breast cancer and in patients with dense breast tissue in the case when mammography and ultrasound fail to fully evaluate the lesion, but the routine use of magnetic resonance imaging in all patients with invasive ductal carcinoma is controversial...
April 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/28397580/the-clinical-application-of-mastectomy-with-single-incision-followed-by-immediate-laparoscopic-assisted-breast-reconstruction-with-latissimus-dorsi-muscle-flap
#16
Huozhong Yuan, Donghua Xie, Xigang Xiao, Xingwei Huang
OBJECTIVE: To explore the clinical application of mastectomy with single incision followed by immediate laparoscopic-assisted breast reconstruction with latissimus dorsi muscle flap. METHODS: Fifteen women with primary early breast cancer, 3 women with breast ductal carcinoma in situ, and 7 women with severe plasma cell mastitis were treated with partial mastectomy or total mastectomy, sentinel lymph node biopsy, or axillary lymph node dissection through a breast lateral transverse incision...
April 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28396790/paul-of-aegina-ca-625-690-ad-an-early-description-of-a-rare-basal-cell-carcinoma-of-the-breast
#17
Gregory Tsoucalas, Markos Sgantzos
Basal cell carcinoma of the breast is a rare type of skin cancer. A probable case reported c.650AD is described with very similar localized symptoms. Understanding its emergence and evolution could improve diagnosis and treatment.
April 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28396716/tumor-reactive-stroma-in-cholangiocarcinoma-the-fuel-behind-cancer-aggressiveness
#18
EDITORIAL
Simone Brivio, Massimiliano Cadamuro, Mario Strazzabosco, Luca Fabris
Cholangiocarcinoma (CCA) is a highly aggressive epithelial malignancy still carrying a dismal prognosis, owing to early lymph node metastatic dissemination and striking resistance to conventional chemotherapy. Although mechanisms underpinning CCA progression are still a conundrum, it is now increasingly recognized that the desmoplastic microenvironment developing in conjunction with biliary carcinogenesis, recently renamed tumor reactive stroma (TRS), behaves as a paramount tumor-promoting driver. Indeed, once being recruited, activated and dangerously co-opted by neoplastic cells, the cellular components of the TRS (myofibroblasts, macrophages, endothelial cells and mesenchymal stem cells) continuously rekindle malignancy by secreting a huge variety of soluble factors (cyto/chemokines, growth factors, morphogens and proteinases)...
March 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28396252/tea-phytochemicals-for-breast-cancer-prevention-and-intervention-from-bench-to-bedside-and-beyond
#19
REVIEW
Dona Sinha, Jaydip Biswas, Seyed Mohammad Nabavi, Anupam Bishayee
The National Cancer Institute of the United States had projected breast cancer as one of the topmost prevalent malignancies of 2016. It was estimated that in 2016, 246,660 new cases of invasive breast cancer were expected to be diagnosed in women in the US, along with 61,000 new cases of non-invasive (in situ) breast cancer. The heterogeneity of breast cancer accounts for its differential molecular subtyping. Recent incorporation of high throughput approaches helps early prognosis of breast cancer, but recurrence of the disease stands to be one of the most daunting fact behind non-availability of third line treatment...
April 7, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28390123/metastatic-carcinoma-of-the-oral-region-an-analysis-of-21-cases
#20
Y-H Lee, J-I Lee
BACKGROUND: Metastatic carcinoma to the jaws and oral region are very rare, representing less than 1% of all oral tumors. Unfortunately, oral metastasis is usually manifestation of an advanced stage of primary cancer, and indicates widespread disease and poor prognosis. MATERIAL AND METHODS: In this retrospective study, a total of 2039 patients with history of oral malignant tumor between 1980 and 2012 at Seoul National University Dental Hospital were evaluated...
April 8, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
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