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https://www.readbyqxmd.com/read/29318579/evaluation-of-icam-1-expression-and-vascular-changes-in-the-skin-of-patients-with-plaque-pustular-and-erythrodermic-psoriasis
#1
Aline L Bressan, Bruna L S Picciani, Luna Azulay-Abulafia, Anna K Fausto-Silva, Paula N Almeida, Karin S G Cunha, Eliane P Dias, Sueli Carneiro
BACKGROUND: Psoriasis is a chronic inflammatory disease. Pustular, erythrodermic, and extensive plaque psoriasis are responsible for systemic complications. Systemic capillary leak syndrome is the complication with greater progression to death and occurs due to vascular changes. PURPOSE: The aim of this study was to evaluate vascular changes through the expression of CD34 and ICAM-1 in plaque, pustular, and erythrodermic psoriasis. METHODS: The sample consisted of seven patients with erythrodermic psoriasis, 24 with moderate-severe plaque psoriasis, 14 with mild plaque psoriasis and 13 with pustular psoriasis...
January 10, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29311041/5-fluorouracil-chemowraps-for-the-treatment-of-multiple-actinic-keratoses
#2
Lucie Peuvrel, Mélanie Saint-Jean, Gaëlle Quereux, Anabelle Brocard, Marie Le Moigne, Cécile Frénard, Amir Khammari, Brigitte Dreno
Few satisfactory treatment options are available for widespread areas affected by multiple actinic keratoses (AKs). Our primary objective was to assess the response rate to weekly 5-fluorouracil (5-FU) chemowraps on widespread AK lesions, and secondarily to assess tolerability, the percentage of patients with recurrence and time to recurrence, the response rate for patients with associated Bowen's disease (BD), and the percentage of squamous cell carcinomas (SCCs) identified after treatment. We conducted an open study which included all the patients who had been treated with weekly 5-FU chemowraps in our department over the course of five years for areas of widespread AKs...
December 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29291224/association-of-two-clusters-of-orf-virus-isolates-in-outbreaks-of-infection-in-goat-in-the-central-anatolian-region-of-turkey
#3
Murat Şevik
Orf virus (ORFV) is the etiological agent of contagious pustular dermatitis and can cause skin disease in sheep and goats. In this study, two outbreaks of ORFV infection in goats in the Central Anatolian region of Turkey were investigated. Samples were collected from 1- to 4-month-old kids (n = 9) in two different flocks in the Aksaray and Konya Provinces during the months of March and May 2016. The presence of ORFV in suspected samples was confirmed by PCR using primers specific to envelope gene (B2L). The analysis of the B2L gene sequences revealed that the nucleotide homology between the two isolates in the present study was 100%, whereas the similarity with Parapoxvirus isolates from different regions ranged from 83...
September 2017: Virusdisease
https://www.readbyqxmd.com/read/29288651/unopposed-il-36-activity-promotes-clonal-cd4-t-cell-responses-with-il-17a-production-in-generalized-pustular-psoriasis
#4
Akiko Arakawa, Sigrid Vollmer, Petra Besgen, Adrian Galinski, Burkhard Summer, Yoshio Kawakami, Andreas Wollenberg, Klaus Dornmair, Michael Spannagl, Thomas Ruzicka, Peter Thomas, Jörg C Prinz
Generalized pustular psoriasis (GPP) is the most severe psoriasis variant. Mutations in the IL-36 antagonist IL36RN, in CARD14 or AP1S3 provide genetic evidence for autoinflammatory aetiology but cannot explain its pathogenesis completely. Here we demonstrate that unopposed IL-36 signalling promotes antigen-driven and likely pathogenic T-helper 17 (Th17) responses in GPP. We observed that CD4+ T cells in blood and skin lesions of GPP patients were characterized by intense hyperproliferation, production of the GPP key mediator, IL-17A, and highly restricted T-cell receptor (TCR) repertoires with identical T-cell clones in blood and skin lesions indicating antigen-driven T-cell expansions...
December 27, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29277927/legionella-feeleii-an-unusual-organism-associated-with-cutaneous-infection-in-an-immunocompromised-patient
#5
S Verykiou, C Goodhead, G Parry, S Meggitt
We report a 23-year-old immunocompromised woman who, following cardiac transplantation, presented with an unusual cutaneous eruption. She developed a widespread pustular rash, systemic symptoms and a high temperature with raised inflammatory markers. The diagnosis was reached when a skin biopsy was cultured onto Legionella agar (buffered charcoal yeast extract) and Legionella feeleii was isolated. The patient was treated with 6 weeks of moxifloxacin and her cutaneous lesions gradually resolved. Cutaneous Legionella infections are uncommon and usually affect immunocompromised patients...
December 26, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29249124/histopathological-aspects-of-psoriasis-and-its-uncommon-variants
#6
Caterina Ferreli, Anna L Pinna, Luca Pilloni, Carlo F Tomasini, Franco Rongioletti
Psoriasis is a chronic complex multisystem, inflammatory, skin disorder that causes vasodilatation and hyperproliferation of keratinocytes, whose clinical expression includes a thickened, erythematous skin, often covered with silver grey scales. Psoriasis is a unique disease where both autoimmune and autoinflammatory responses coexist and the balance between the two components is essential in determining its clinical and histopathological presentation. Adaptive immune responses prevail in chronic plaque psoriasis while innate and autoinflammatory responses predominate in pustular psoriasis...
December 15, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29245497/a-new-species-of-direct-developing-frog-of-the-genus-i-pristimantis-i-anura-terrarana-craugastoridae-from-cordillera-del-c%C3%A3-ndor-ecuador-with-comments-on-threats-to-the-anuran-fauna-of-the-region
#7
Jorge H Valencia, Manuel R Dueñas, Paul Székely, Diego Batallas, Francisco Pulluquitín, Santiago R Ron
A new frog in the genus Pristimantis is described from a cloud forest on the western flanks of the Cordillera del Cóndor and eastern Andean slopes in the province of Zamora Chinchipe, southeastern of Ecuador. We inferred its phylogenetic position using DNA sequences of mitochondrial and nuclear genes. The new species is strongly supported as part of a clade that includes P. ardalonychus, P. cajamarcensis, P. ceuthospilus, P. chalceus, P. minutulus, P. luteolateralis, P. parvillus, P. ockendeni, P. unistrigatus, and P...
November 24, 2017: Zootaxa
https://www.readbyqxmd.com/read/29236848/histopatology-of-the-reproductive-tract-of-nellore-pubertal-heifers-with-genital-ureaplasmosis
#8
Regiani Pôrto, Benedito Oliveira Filho, Henrique Ferraz, Luciano Caixeta, Marco Antonio Viu, Maria Lúcia Gambarini
In order to study and characterize the lesions in the reproductive tract of Nellore heifers naturally infected with Ureaplasma diversum and presenting granular vulvovaginitis syndrome (GVS), fragments of uterine tube, uterus, cervix, vagina and vulva of 20 animals were evaluated. The macroscopic lesions of the vulvovaginal mucosa were classified in scores of "1" mild, until "4", severe inflammation and pustular or necrotic lesions. The histopathological evaluation was performed using scores of "1" to "4", according to the inflammatory alterations...
December 7, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29232032/erosive-pustular-dermatosis-of-the-scalp-reappraisal-of-an-underrecognized-entity
#9
REVIEW
Michael Wilk, Bettina G Zelger, Undine Hauser, Reinhard Höpfl, Bernhard Zelger
Erosive pustular dermatosis of the scalp (EPDS) is an inflammatory dermatosis of unknown etiology. Herein, we present a review of the disease and report our own clinical and histopathological experience in eleven patients. EPDS tends to spontaneously affect bald areas of the scalp in elderly individuals. A history of previous surgery at the same site - as observed in four of our patients - is common. Coronary artery disease, cerebrovascular insult, arterial hypertension, diabetes mellitus, and severe cases of cancer were frequent comorbidities...
December 12, 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29230387/hyperpigmentation-of-the-hard-palate-mucosa-in-a-patient-with-chronic-myeloid-leukaemia-taking-imatinib
#10
Gian Paolo Bombeccari, Umberto Garagiola, Francesco Pallotti, Margherita Rossi, Massimo Porrini, Aldo Bruno Giannì, Francesco Spadari
Background: Imatinib mesylate is an inhibitor of the tyrosine kinase Bcr-Abl and a first-line treatment for Philadelphia chromosome-positive chronic myeloid leukaemia (CML). Dermatological side effects include superficial oedema, pustular eruption, lichenoid reactions, erythroderma, and skin rash. Depigmentation of the skin and/or mucosa is uncommon, and hyperpigmentation is rare. Case presentation: We present the case of a 63-year-old Caucasian male with widespread hyperpigmentation of the hard palate associated with a 9-year history of imatinib therapy to treat CML...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29226159/immunohistopathological-findings-of-severe-cutaneous-adverse-drug-reactions
#11
REVIEW
Mari Orime
Diagnosis of severe cutaneous adverse drug reactions should involve immunohistopathological examination, which gives insight into the pathomechanisms of these disorders. The characteristic histological findings of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) provide conclusive evidence demonstrating that SJS/TEN can be distinguished from EM. Established SJS/TEN shows full-thickness, extensive keratinocyte necrosis that develops into subepidermal bullae. Drug-induced hypersensitivity syndrome (DIHS) and exanthema in drug reaction with eosinophilia and systemic symptoms (DRESS) each display a variety of histopathological findings, which may partly correlate with the clinical manifestations...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29215143/generalized-pustular-psoriasis-in-a-92-year-old-man-with-a-homozygous-nonsense-mutation-in-il36rn
#12
Yoshitaka Ueda, Mayumi Komine, Koji Kamiya, Hidetoshi Tsuda, Takeo Maekawa, Satoru Murata, Mamitaro Ohtsuki
A 92-year-old man developed an erythematous eruption on the trunk and extremities with numerous pustules accompanied by fever. He had never experienced pustular eruption or been diagnosed with psoriasis previously. Skin biopsy revealed Kogoj's spongiform pustule, and he was diagnosed with generalized pustular psoriasis (GPP). Genomic DNA was extracted from his peripheral blood and the sequence of IL36RN gene was analyzed, which revealed a p.Arg10X homozygous mutation. Several cases of elderly-onset GPP have been reported, however, this is the oldest case of GPP...
December 7, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29193195/presence-of-stratum-corneum-serum-in-non-palmoplantar-psoriasis
#13
Sunisha Chahal, Ben Tallon
BACKGROUND: Psoriasis is a common, chronic skin eruption characterized by abnormal hyperproliferation of the epidermis. When assessing psoriasis histologically, it is historically considered a "dry" disease, with significant amounts of serum not expected within lesional stratum corneum. However, this specific feature is not often mentioned within the literature. A retrospective study was undertaken to assess prevalence of serum within stratum corneum in cases of non-palmoplantar psoriasis...
November 28, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29191346/neutrophilic-dermatoses-kids-are-not-just-little-people
#14
Grace L Lee, Amy Y-Y Chen
Neutrophilic dermatoses are a group of inflammatory skin disorders characterized by an overactive innate immune system with dysregulation of neutrophils without underlying infectious etiology. The major representative conditions discussed are Sweet syndrome; pyoderma gangrenosum; neutrophilic eccrine hidradenitis; palmoplantar eccrine hidradenitis; subcorneal pustular dermatoses; bowel-associated dermatosis arthritis syndrome; and synovitis, acne, pustulosis, hyperostosis, and osteitis. We will also discuss other neutrophilic conditions present almost exclusively in the pediatric population, including congenital erosive and vesicular dermatosis with reticulated supple scarring and the recently described group of autoinflammatory diseases...
November 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/29186260/acute-generalized-exanthematous-pustulosis-induced-by-hydroxychloroquine-a-case-with-atypical-clinical-presentation
#15
Hatice Duman, Ilteris Oguz Topal, Emek Kocaturk, Kubra Cure, Ilknur Mansuroglu
Acute generalized exanthematous pustulosis is a rare drug-induced eruption that is characterized by acute, nonfollicular sterile pustules on an erythematous and edematous base. The most frequently implicated drugs are beta-lactam antibiotics. Hydroxychloroquine has been widely used to treat dermatologic and rheumatologic diseases and has been reported as a rare cause of acute generalized exanthematous pustulosis. A 42-year-old female presented with pustular lesions on the skin surface with erythema, facial edema, and occasional atypical target-like lesions after 21 days of treatment with 200mg/day hydroxychloroquine for rheumatoid arthritis, diagnosed one month previously...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29186241/clinical-features-of-von-zumbusch-type-of-generalized-pustular-psoriasis-in-children-a-retrospective-study-of-26-patients-in-southwestern-china
#16
Qian Wang, Wei Liu, Lixia Zhang
BACKGROUND: Von Zumbusch type of generalized pustular psoriasis is a rare variant of psoriasis in children. It can occur in patients with or without psoriasis vulgaris. OBJECTIVE: The aim of the study was to discuss the precipitating factors, clinical manifestations, laboratory data and therapy of von Zumbusch type of generalized pustular psoriasis in children from southwestern China and to improve the diagnosis and treatment level. METHODS: A retrospective analysis was conducted for inpatients aged 14 years old or less with von Zumbusch type of generalized pustular psoriasis in our department from 2005 to 2014...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29177142/highly-resistant-acrodermatitis-continua-of-hallopeau-and-pustular-psoriasis
#17
John W Frew, Dedee F Murrell
No abstract text is available yet for this article.
October 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29168210/abrupt-generalized-pustules-in-patients-with-rheumatoid-arthritis-and-interstitial-lung-disease
#18
Wei Deng, Chaoyang Miao, Xiaoyan Zhang
We report a case of a 30-year-old Chinese woman with rheumatoid arthritis and interstitial lung disease who abruptly developed generalized pustules and a high fever for 10 days. She had been taking oral prednisone, iguratimod and total glucosides of peony regularly for 5 months prior. In addition, she had taken metronidazole for 3 days 20 days prior which she had used before with no adverse reaction. She had no history of similar lesions and psoriasis. A biopsy of a pustule on the back showed spongiform pustule of Kogoj...
November 23, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29153035/an-unusual-presentation-of-pseudocowpox-associated-with-an-outbreak-of-pustular-ulcerative-vulvovaginitis-in-a-swedish-dairy-herd
#19
Gunilla Blomqvist, Karin Ullman, Thomas Segall, Elenor Hauzenberger, Lena Renström, Karin Persson-Waller, Mikael Leijon, Jean-Francois Valarcher
Species Pseudocowpox virus (PCPV; family Poxviridae) is known to cause pustular cutaneous disease in cattle. We describe an outbreak of pseudocowpox with an unusual clinical picture in a free-stall dairy herd of ~80 cows. Approximately 90% of the cows had vesicles, erosions, papules, and scabs on the vulva and vaginal mucosa. Histologic analysis of biopsy tissues indicated a primary, although not specified, viral infection. Transmission electron microscopy revealed parapoxvirus particles in both tissue and vesicular materials...
November 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29143230/the-efficacy-of-biologic-therapy-for-the-management-of-palmoplantar-psoriasis-and-palmoplantar-pustulosis-a-systematic-review
#20
REVIEW
Isabelle M Sanchez, Eric Sorenson, Ethan Levin, Wilson Liao
INTRODUCTION: Palmoplantar psoriasis (PP) and palmoplantar pustulosis (PPP) are diseases affecting the hands and/or feet that can cause marked physical discomfort and functional disability. The tumor necrosis factor-alpha antagonists adalimumab, etanercept, and infliximab, the interleukin (IL)-17A inhibitors ixekizumab and secukinumab, and the IL-23 or IL-12/IL-23 inhibitors guselkumab and ustekinumab have been well studied for the treatment of moderate to severe plaque psoriasis. Less is known about the efficacy and safety of these agents for the treatment of PP (hyperkeratotic and pustular forms) and PPP...
December 2017: Dermatology and Therapy
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