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https://www.readbyqxmd.com/read/28063630/clinical-profiles-of-pediatric-patients-with-gpp-alone-and-with-different-il36rn-genotypes
#1
Yirong Wang, Ruhong Cheng, Zhiyong Lu, Yifeng Guo, Ming Yan, Jianying Liang, Peichen Huang, Ming Li, Zhirong Yao
BACKGROUND: IL36RN mutation has been identified as one pathogenesis of generalized pustular psoriasis, but the existence of GPP patients without mutation makes this controversial. OBJECTIVE: Our study aimed at assessing the differences in clinical profiles of children with GPP, with and without IL36RN mutation. METHODS: An ambispective case series study involved review of the records of 66 childhood patients with pediatric-onset GPP and without previous psoriasis vulgaris...
December 13, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28043870/il-1-and-il-36-are-dominant-cytokines-in-generalized-pustular-psoriasis
#2
Andrew Johnston, Xianying Xing, Liza Wolterink, Drew H Barnes, ZhiQiang Yin, Laura Reingold, J Michelle Kahlenberg, Paul W Harms, Johann E Gudjonsson
BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, debilitating, and often life-threatening inflammatory disease characterized by episodic infiltration of neutrophils into the skin, pustule development, and systemic inflammation, which can manifest in the presence or absence of chronic plaque psoriasis (PV). Current treatments are unsatisfactory warranting a better understanding of GPP pathogenesis. OBJECTIVE: To understand better the disease mechanism of GPP to allow improved targeted therapies...
December 30, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28000249/amicrobial-pustulosis-of-the-folds-report-of-4-cases
#3
Michael Z Wang, Michael J Camilleri, Ruifeng Guo, Carilyn N Wieland
Amicrobial pustulosis of the folds (APF) is a rare disease characterized by aseptic pustular lesions involving cutaneous folds, typically occurring in the context of an autoimmune disorder. We present 4 patients with APF, focusing on clinical and histopathologic characteristics to improve the recognition of this entity. All 4 patients had intertriginous and extra-intertriginous involvement. Common histopathologic features of skin biopsies in these patients were intracorneal, subcorneal, intraepidermal, perivascular, perifollicular, and interstitial neutrophilic inflammation...
December 21, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27998165/neutrophilic-dermatosis-of-dorsal-hands-and-legs
#4
Elham Behrangi, Abbas Rasi, Bahamin Attar, Zahra Azizian
We present a case of neutrophilic dermatosis of dorsal hands (NDDH), with lesions on the dorsal part of the hands with pustular features and histologic picture of vasculitis.This case highlights the notion that low dose oral steroid can offer a useful first therapeutic option for NDDH. Interstingly, in this case, a few additional lesions were located on the legs, making it different from some previously described cases of NDDH. As with other authors, we believe that this recently described neutrophilic dermatosis is a localized and acral variant of SS...
December 2016: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/27997815/annular-pustular-psoriasis-in-a-14-month-old-girl-a-therapeutic-challenge
#5
Victoria Haug, Sandrine Benoit, Michael Wohlleben, Henning Hamm
: Annular pustular psoriasis (annular PP) is a rare but severe variant of psoriasis which may even occur in early childhood. At this age therapeutic options are limited and medication issues can be challenging. We report clinical features, diagnostic findings and treatment of an 11-month-old girl with annular PP. Oral acitretin therapy was initiated at 0.9 mg/kg/d and gradually tapered after complete resolution in the subsequent 10 months without relapse. CONCLUSION: Acitretin proved to be a highly effective therapeutic option in an infant with annular PP...
December 20, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27990381/psoriasis-epidemiology-clinical-features-co-morbidities-and-clinical-scoring
#6
Sunil Dogra, Rahul Mahajan
On the basis of current evidence derived from hospital-based studies, mostly from North India, the prevalence of psoriasis in adults varies from 0.44 to 2.8%, with a much lower prevalence in children. The peak age at onset in adults is in the third and fourth decade of life, with a slight male preponderance. It is recommended that population-based large epidemiologic studies should be undertaken in different parts of the country for estimating the correct prevalence of psoriasis in general population. Chronic plaque-type psoriasis is the most common morphologic presentation of psoriasis, accounting for more than 90% of all cases...
November 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27981221/successful-use-of-secukinumab-in-pustular-psoriasis
#7
Jensen Yeung, Venus Valbuena
No abstract text is available yet for this article.
November 2016: JAAD Case Reports
https://www.readbyqxmd.com/read/27976437/monitoring-structural-changes-in-demodex-mites-under-topical-ivermectin-in-rosacea-by-means-of-reflectance-confocal-microscopy-a-case-series
#8
LETTER
C Ruini, E Sattler, D Hartmann, M Reinholz, T Ruzicka, T von Braunmühl
No abstract text is available yet for this article.
December 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27939314/17-th-century-variola-virus-reveals-the-recent-history-of-smallpox
#9
Ana T Duggan, Maria F Perdomo, Dario Piombino-Mascali, Stephanie Marciniak, Debi Poinar, Matthew V Emery, Jan P Buchmann, Sebastian Duchêne, Rimantas Jankauskas, Margaret Humphreys, G Brian Golding, John Southon, Alison Devault, Jean-Marie Rouillard, Jason W Sahl, Olivier Dutour, Klaus Hedman, Antti Sajantila, Geoffrey L Smith, Edward C Holmes, Hendrik N Poinar
Smallpox holds a unique position in the history of medicine. It was the first disease for which a vaccine was developed and remains the only human disease eradicated by vaccination. Although there have been claims of smallpox in Egypt, India, and China dating back millennia [1-4], the timescale of emergence of the causative agent, variola virus (VARV), and how it evolved in the context of increasingly widespread immunization, have proven controversial [4-9]. In particular, some molecular-clock-based studies have suggested that key events in VARV evolution only occurred during the last two centuries [4-6] and hence in apparent conflict with anecdotal historical reports, although it is difficult to distinguish smallpox from other pustular rashes by description alone...
December 19, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27938808/palmoplantar-psoriasis
#10
Burhan Engin, Özge Aşkın, Yalçın Tüzün
Palmoplantar psoriasis refers to a localized psoriasis variant. The disease can be associated with many clinical forms, including predominantly pustular lesions to thick scaly, hyperkeratotic plaques, or an overlapping of both of them. Palmoplantar psoriasis accounts for 3-4% of all psoriasis cases in most studies. Although it is localized only on the palms and the soles, the fissures, the hardening of the tissue, and hyperkeratosis affect daily routine activities. Taking the body surface area as a measure of severity can sometimes be misleading...
January 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/27936239/a-broad-spectrum-chemokine-binding-protein-of-bovine-papular-stomatitis-virus-inhibits-neutrophil-and-monocyte-infiltration-in-inflammatory-and-wound-models-of-mouse-skin
#11
Saeed Sharif, Yoshio Nakatani, Lyn Wise, Michael Corbett, Nicola C Real, Gabriella S Stuart, Zabeen Lateef, Kurt Krause, Andrew A Mercer, Stephen B Fleming
Bovine papular stomatitis virus (BPSV) is a Parapoxvirus that induces acute pustular skin lesions in cattle and is transmissible to humans. Previous studies have shown that BPSV encodes a distinctive chemokine-binding protein (CBP). Chemokines are critically involved in the trafficking of immune cells to sites of inflammation and infected tissue, suggesting that the CBP plays a role in immune evasion by preventing immune cells reaching sites of infection. We hypothesised that the BPSV-CBP binds a wide range of inflammatory chemokines particularly those involved in BPSV skin infection, and inhibits the recruitment of immune cells from the blood into inflamed skin...
2016: PloS One
https://www.readbyqxmd.com/read/27915962/generalized-pustular-psoriasis-von-zumbusch-type-following-renal-transplant-a-case-report
#12
Georgia Dedemadi, Maria Koukoulaki, Vassileios Vougas, Constantinos Noutsis, Aikaterini Pantelidaki, Spiros Drakopoulos
Generalized pustular psoriasis appears as an uncommon variant form of psoriasis consisting of widespread pustules on an erythematous background (von Zumbusch). A 39-year-old male patient with a history of plaque psoriasis since the age of 9 who had an acute relapse of generalized pustular psoriasis 12 days following a successful renal transplantation is presented. Despite administered immunosuppression for transplantation, the addition of cyclosporine and methotrexate did not reverse the ongoing process of disease and the patient died on the 57th posttransplant day due to multiorgan failure subsequent to severe bone marrow suppression...
December 2, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27904292/a-case-of-acrodermatitis-continua-accompanying-with-osteolysis-and-atrophy-of-the-distal-phalanx-that-evoluted-into-generalized-pustular-psoriasis
#13
Kyung Ho Kim, Hong Lim Kim, Hyun Yi Suh, Jae Wook Jeon, Ji Young Ahn, Mi Youn Park, Jai Il Youn
No abstract text is available yet for this article.
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27900482/mutations-in-il36rn-are-associated-with-geographic-tongue
#14
Jianying Liang, Peichen Huang, Huaguo Li, Jia Zhang, Cheng Ni, Yirong Wang, Jinwen Shen, Chunxiao Li, Lu Kang, Jie Chen, Hui Zhang, Zhen Wang, Zhen Zhang, Ming Li, Zhirong Yao
Geographic tongue (GT) is a benign inflammatory disorder of unknown etiology. Epidemiology and histopathology in previous studies found that generalized pustular psoriasis (GPP) is a factor associated with GT, but the molecular mechanism remains obscure. To investigate the mechanism of GT, with and without GPP, three cohorts were recruited to conduct genotyping of IL36RN, which is the causative gene of GPP. In a family spanning three generations and diagnosed with only GT ("GT alone"), GT was caused by the c...
November 29, 2016: Human Genetics
https://www.readbyqxmd.com/read/27896279/a-case-of-relapsing-polyarthritis-associated-with-hidradenitis-suppurativa-case-report-and-review-of-literature
#15
Avinash Adiga, John Pixley
Hidradenitis suppurativa (HS) is a chronic, inflammatory follicular skin disease with recurrent skin nodules, sinus tracts, and scarring. We observed a case of HS associated with relapsing polyarthritis. On presentation the patient had a flare of polyarthritis with an increase in the number and size of pustular nodules. He has had similar episodes 1 to 2 times yearly subsiding with antibiotic treatment. Radiographs revealed erosions and demineralization. Symptoms improved following institution of anti-inflammatory and antibiotic therapy...
October 2016: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/27891724/establishing-a-canine-superficial-pyoderma-model
#16
W Bäumer, P Bizikova, M Jacob, K E Linder
AIMS: Pyoderma, predominantly associated with Staphylococcus pseudintermedius, is a common skin infection of dogs that typically requires long-lasting treatments, complicated by increasing antimicrobial resistance. To investigate new treatment strategies, we aimed at establishing a dog model of pyoderma that closely mimics the natural disease. METHODS AND RESULTS: We inoculated six laboratory beagles with a methicillin-susceptible strain of S. pseudintermedius. One millilitre of approximately 10(7) , 10(8) , 10(9) CFU per ml was topically applied onto clipped and tape stripped area of dog skin, which was then treated with a dermaroller (microneedle size: 500 μm) immediately after administration...
November 27, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27884600/six-transmembrane-epithelial-antigens-of-the-prostate-comprise-a-novel-inflammatory-nexus-in-patients-with-pustular-skin-disorders
#17
Yun Liang, Xianying Xing, Maria A Beamer, William R Swindell, Mrinal K Sarkar, Liza Wolterink Roberts, John J Voorhees, J Michelle Kahlenberg, Paul W Harms, Andrew Johnston, Johann E Gudjonsson
BACKGROUND: Pustular skin disorders are a category of difficult-to-treat and potentially life-threatening conditions that involve the appearance of neutrophil-rich pustules. The molecular basis of most pustular skin conditions has remained unknown. OBJECTIVE: We sought to investigate the molecular basis of 3 pustular skin disorders: generalized pustular psoriasis (GPP), palmoplantar pustulosis (PPP), and acute generalized exanthematous pustulosis (AGEP). METHODS: Microarray analyses were performed to profile genome-wide gene expression of skin biopsy specimens obtained from patients with GPP, PPP, or AGEP and healthy control subjects...
November 21, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27882662/painful-pustular-groin-eruption-in-a-teenage-boy
#18
Rachel Laarman, Kimberly A Horii
No abstract text is available yet for this article.
November 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27882586/efficacy-and-safety-of-dose-escalation-of-infliximab-therapy-in-japanese-patients-with-psoriasis-results-of-the-spread-study
#19
Hideshi Torii, Masayuki Nakano, Toshiro Yano, Kazuoki Kondo, Hidemi Nakagawa
Although infliximab is approved for psoriasis, its efficacy is reduced over time in some patients. The aim of this phase III trial is to evaluate efficacy and safety of infliximab dose escalation in Japanese psoriasis patients with loss of efficacy to standard-dose therapy. Patients with plaque psoriasis, psoriatic arthritis, pustular psoriasis or psoriatic erythroderma who showed loss of efficacy to standard-dose therapy received infliximab dose escalation (10 mg/kg every 8 weeks) from weeks 0 to 32. Loss of efficacy was defined as not maintaining 50% reduction in the Psoriasis Area and Severity Index (PASI 50) after achieving PASI 75...
November 24, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27881938/are-interleukin-15-and-22-a-new-pathogenic-factor-in-pustular-palmoplantar-psoriasis
#20
Aleksandra Lesiak, Igor Bednarski, Marta Pałczyńska, Ewelina Kumiszcza, Marzena Kraska-Gacka, Anna Woźniacka, Joanna Narbutt
INTRODUCTION: Pustular palmoplantar psoriasis (PPP) is a rare type of psoriasis affecting mainly distal parts of the limbs. Despite numerous theories about etiology of PPP, the pathogenesis still remains unclear. Recent data indicate that interleukin (IL)-15, IL-17 and IL-22 enhance a proinflammatory response in certain skin inflammatory diseases such as psoriasis and atopic dermatitis. There is also evidence that anti-endomysial (anti-EMA) and anti-gliadin (AGA) antibodies are engaged in PPP development...
October 2016: Postȩpy Dermatologii i Alergologii
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