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https://www.readbyqxmd.com/read/29143230/the-efficacy-of-biologic-therapy-for-the-management-of-palmoplantar-psoriasis-and-palmoplantar-pustulosis-a-systematic-review
#1
REVIEW
Isabelle M Sanchez, Eric Sorenson, Ethan Levin, Wilson Liao
INTRODUCTION: Palmoplantar psoriasis (PP) and palmoplantar pustulosis (PPP) are diseases affecting the hands and/or feet that can cause marked physical discomfort and functional disability. The tumor necrosis factor-alpha antagonists adalimumab, etanercept, and infliximab, the interleukin (IL)-17A inhibitors ixekizumab and secukinumab, and the IL-23 or IL-12/IL-23 inhibitors guselkumab and ustekinumab have been well studied for the treatment of moderate to severe plaque psoriasis. Less is known about the efficacy and safety of these agents for the treatment of PP (hyperkeratotic and pustular forms) and PPP...
November 15, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29140836/pyoderma-gangrenosum-a-critical-appraisal
#2
Eran Shavit, Afsaneh Alavi, R Gary Sibbald
GENERAL PURPOSE: To provide information about pyoderma gangrenosum (PG), including pathophysiology, diagnostic criteria, and treatment. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After participating in this educational activity, the participant should be better able to: ABSTRACT: Pyoderma gangrenosum (PG) is an uncommon cutaneous disease, presenting with recurrent painful ulcerations most commonly on the lower extremities...
December 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29136067/vesiculobullous-and-pustular-diseases-in-newborns
#3
Kate E Oberlin
This article exhibits the most common presentations of vesiculobullous diseases in newborns and reviews the clinical characteristics unique to each diagnosis. Furthermore, a schematic for the workup of neonatal vesicular disorders is presented to empower dermatology residents to execute accurate diagnoses and maximize patient care.
October 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29131037/paradoxical-reactions-anti-tumor-necrosis-factor-alpha-agents-ustekinumab-secukinumab-ixekizumab-and-others
#4
Lluís Puig
Paradoxical reactions during treatment with a biologic agent can be defined as the appearance or exacerbation of a pathological condition that usually responds to this class of drug while treating a patient for another condition, which usually remains under control (even though there may be a change in morphology or phenotype). Paradoxical reactions were initially described as isolated case reports or case series in patients treated with anti-tumor necrosis factor (TNF) α agents, first in inflammatory rheumatic diseases, later in psoriasis and inflammatory bowel disease...
2018: Current Problems in Dermatology
https://www.readbyqxmd.com/read/29121139/atypical-fibroxanthoma-arising-within-erosive-pustular-dermatosis-of-the-scalp
#5
Jeffrey D Cizenski, Ramsay S Farah
We describe a painful atypical fibroxanthoma (AFX) arising in a setting of erosive pustular dermatosis of the scalp. Complete excision was curative and also was associated with resolution of pain and clearance of the erosive pustular dermatosis of the scalp. We review the diagnosis and management of AFX and discuss the role of actinic damage in this process.
September 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29119028/erosive-pustular-dermatosis-of-the-scalp-with-urate-like-crystals
#6
Patrick O Emanuel, Sharad P Paul
Follicular urate-like crystals were first described in Necrotizing Infundibular Crystalline Folliculitis (NICF), a rare cutaneous disorder with multiple waxy folliculocentric papules. Similar crystal accumulation may be seen within follicular infundibulae as an incidental finding. We describe a case showing identical crystals occurring within the horn-like crusts of a patient with erosive pustular dermatosis of the scalp (EPDS), a condition which due to its presentation can often be mistaken for nonmelanoma skin cancer...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29118470/diagnostic-utility-and-pitfalls-of-tzanck-smear-cytology-in-diagnosis-of-various-cutaneous-lesions
#7
Hemlata Panwar, Deepti Joshi, Garima Goel, Dinesh Asati, Kaushik Majumdar, Neelkamal Kapoor
Aims: Tzanck smear is an old but useful test for diagnosis of cutaneous dermatoses. The aim of this study was to highlight the potential usefulness and diagnostic pitfalls of Tzanck smear for diagnosis of cutaneous dermatoses and infections. Materials and Methods: This hospital based cross-sectional study was carried out on all Tzanck smears received for a period of twenty months (January 2014-August 2015). The smears were assessed to establish the utility of Tzanck smears in corroborating or excluding a diagnosis of immunobullous lesion or herpetic infection...
October 2017: Journal of Cytology
https://www.readbyqxmd.com/read/29115687/epidemiological-survey-from-2009-to-2012-of-psoriatic-patients-in-japanese-society-for-psoriasis-research
#8
Toshihiro Ito, Hidetoshi Takahashi, Akira Kawada, Hajime Iizuka, Hidemi Nakagawa
Since 1982, the Japanese Society for Psoriasis Research has conducted annual epidemiological surveys of patients with psoriasis. Kawada et al. have reported data for 1982-2001 and Takahashi et al. have reported data for 2002-2008. The present study evaluated 9290 psoriatic cases according to age and sex (2009-2012). The male : female ratio was 2.08:1 (6281 male patients [67.6%] to 3009 female patients [32.4%]). The most prevalent type was psoriasis vulgaris (85.6% of all cases), which was followed by psoriasis arthropathica (6...
November 8, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29098909/efficacy-and-safety-of-acitretin-monotherapy-in-children-with-pustular-psoriasis-results-from-15-cases-and-a-literature-review
#9
Pingjiao Chen, Changxing Li, Rujun Xue, Huiheng Chen, Xin Tian, Kang Zeng, Xibao Zhang, Jingyao Liang
BACKGROUND: There is a few evidence-based information regarding the efficacy and safety of acitretin treatment in children with pustular psoriasis (PP). OBJECTIVE: This study aimed to provide an additional evidence for this field. METHODS: A retrospective study was undertaken for 15 children with PP, received acitretin in doses of 0.6-1.0 mg/kg/day for 4-6 weeks, the transition dose in 0.2-0.4mg/kg/day for 4-6 weeks and maintenance dose of 0...
November 3, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29050452/erosive-pustular-dermatosis-of-the-leg-an-uncommon-entity
#10
Alessandro Pileri, Cosimo Misciali, Carlotta Baraldi, Andrea Sechi, Mario Faenza, Pier A Fanti, Andrea Stella, Annalisa Patrizi
No abstract text is available yet for this article.
December 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29049442/pustular-eruption-in-a-patient-with-cancer-treated-with-complementary-and-alternative-medicine
#11
Josh A Hammel, John C Selby
No abstract text is available yet for this article.
October 11, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29047148/epidemiological-survey-of-patients-with-psoriasis-in-matsumoto-city-nagano-prefecture-japan
#12
Eisaku Ogawa, Ryuhei Okuyama, Tomoko Seki, Aya Kobayashi, Naoki Oiso, Masahiko Muto, Hidemi Nakagawa, Akira Kawada
A local epidemiological survey of psoriasis was conducted from 19 February to 30 June 2016 in Matsumoto city, Nagano Prefecture, Japan. Patients were predominantly male (268 cases, 71.5% males vs 107 cases, 28.5% females). We estimated that the prevalence of psoriasis was 0.097% in the Matsumoto area. The clinical types of psoriasis identified were psoriasis vulgaris (90.7%), psoriatic arthritis (5.9%), pustular psoriasis (2.1%), guttate psoriasis (1.0%) and psoriatic erythroderma (0.3%). The topical therapeutic agents included corticosteroids (84...
October 19, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29034454/successful-treatment-of-sapho-syndrome-with-apremilast
#13
S Adamo, J Nilsson, A Krebs, U Steiner, A Cozzio, L E French, A G A Kolios
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a rare disease with inflammatory osteoarticular and skin involvement. The pathogenesis of SAPHO syndrome remains unclear, but evidence suggests it may be an autoinflammatory disease triggered upon exposure to infectious agents in genetically predisposed individuals. Induction of the IL-23/Th17 axis as well as neutrophil activation seem to play a key role, and therapies targeting these immunological pathways, including TNF-inhibitors, ustekinumab, secukinumab and the IL-1 inhibitor anakinra are potential treatment options that need further investigation...
October 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29034298/generalized-pustular-psoriasis-treated-with-apremilast-in-a-patient-with-multiple-medical-comorbidities
#14
Caleb Jeon, Mio Nakamura, Sahil Sekhon, Di Yan, Jashin J Wu, Wilson Liao, Tina Bhutani
No abstract text is available yet for this article.
November 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/29027743/generalized-pustular-psoriasis-triggered-by-zika-virus-infection
#15
A E Paniz Mondolfi, M Hernandez Perez, G Blohm, M Marquez, A Mogollon Mendoza, C E Hernandez-Pereira, M A Escalona, A Lodeiro Colatosti, J Rothe DeArocha, A J Rodriguez Morales
Zika virus is an emerging arbovirus, which is expanding in epidemic proportions through tropical and subtropical areas of the world. Although Zika is linked to a number of congenital and neurological complications, there is scarce knowledge on the impact of ZIKV infection in human skin. We report the case of a 68-year old woman who presented with generalized pustular psoriasis after a preceding and otherwise uneventful episode of ZIKV infection. Based on recent experimental data on the biology of ZIKV infection in the cutaneous environment, we speculate that ZIKV may have directly triggered the development of generalized pustular psoriasis by stimulation of keratinocyte-derived mediators of inflammation and a polyfunctional T-cell driven immune reaction in the cutaneous milieu...
October 13, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29023827/tnf%C3%AE-and-il-17a-are-differentially-expressed-in-psoriasis-like-vs-eczema-like-drug-reactions-to-tnf%C3%AE-antagonists
#16
C Deubelbeiss, A G A Kolios, L E French, N Yawalkar, W Kempf, K Kerl, B Meier, F Anzengruber, A A Navarini
BACKGROUND: Tumor necrosis factor α (TNFα) blocking drugs are in use for a wide range of autoimmune disorders. In up to 5% of patients, this class of drugs produces puzzling cutaneous side effects that are the subject of this investigation, namely psoriasiform and eczema-like skin inflammation. These side effects can occur after any time of treatment and regardless of the underlying disorders. The exact pathophysiology is as yet unknown. METHODS: 33 patients (19 female, average age 52 years) who had a cutaneous reaction to infliximab, adalimumab or etanercept were included...
October 10, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28984691/intracorneal-pustular-drug-eruption-a-novel-cutaneous-adverse-event-in-anti-programmed-cell-death-1-patients-that-highlights-the-effect-of-anti-programmed-cell-death-1-in-neutrophils
#17
Cathy Yunjia Zhao, Germana Consuegra, Shaun Chou, Pablo Fernández-Peñas
The introduction of anti-programmed cell death-1 (anti-PD1) monoclonal antibodies has revolutionized the treatment of various advanced malignancies. Despite its efficacy, anti-PD1 therapy is accompanied by a variety of cutaneous adverse events. A 79-year-old man developed erythematous scaly plaques and pustules of the forehead, legs and arms after four cycles of nivolumab infusions every 2 weeks. Histology showed intracorneal pustules with dermal neutrophils and eosinophils. He was treated successfully with topical corticosteroids without discontinuation of nivolumab...
December 2017: Melanoma Research
https://www.readbyqxmd.com/read/28983976/an-unresponsive-progressive-pustular-and-crusting-dermatitis-with-acantholysis-in-nine-cats
#18
Catherine A Outerbridge, Verena K Affolter, Leslie A Lyons, Samantha L Crothers, Andrea T H Lam, Terri E Bonenberger, Peter J Ihrke, Stephen D White
BACKGROUND: Between 2000 and 2012, nine cats were examined with a visually distinctive, progressive crusting dermatitis that was poorly responsive to all attempted therapies. OBJECTIVES: Documentation of clinical and histopathological findings of this disease. ANIMALS: Nine privately owned cats. METHODS: Retrospective study. RESULTS: Eight neutered males and one (presumably spayed) female ranging in age from two to eight years, presented for a progressive, well-demarcated, crusting dermatitis with variable pruritus of 1...
October 6, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28979866/cutaneous-manifestations-of-chikungunya-fever-observations-from-an-outbreak-at-a-tertiary-care-hospital-in-southeast-rajasthan-india
#19
Ramesh Kumar, Manoj K Sharma, Suresh K Jain, Sumit K Yadav, Anil K Singhal
BACKGROUND: Chikungunya fever is caused by chikungunya virus which is transmitted by the bite of infected Aedes aegypti and A. albopictus mosquitoes. AIMS: To study the various mucocutaneous manifestations in suspected cases of chikungunya fever. MATERIALS AND METHODS: The patients who attended our outpatient department from July 2016 to October 2016 and fulfilled the criteria for "suspect cases" of chikungunya infection stipulated by the National Institute of Communicable Diseases, Directorate General of Health Services, Government of India, were included in the study prospectively...
September 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28979621/recurrent-impetigo-herpetiformis-case-report
#20
Emmanuel Wekesa Wamalwa
Impetigo herpetiformis (pustular psoriasis of pregnancy) is a rare dermatosis of pregnancy that typically starts in the 2(nd) half of pregnancy and resolves postpartum. It may recur in subsequent pregnancies. I present a case of 23 year old female gravida 4 para 3 with recurrent impetigo herpetiformis at 26 weeks gestation. She presented with a one month history of pustular lesions which responded to treatment with prednisone. She delivered at term with a favourable outcome. The disease resolved one month postpartum...
2017: Pan African Medical Journal
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