Yuxiang Liang, Ying Wang, Xiao Zhang, Shanshan Jin, Yuqian Guo, Zhaowei Yu, Xinrui Xu, Qizhi Shuai, Zihan Feng, Binghong Chen, Ting Liang, Ruifang Ao, Jianting Li, Juan Zhang, Rui Cao, Hong Zhao, Zhaoyang Chen, Zhizhen Liu, Jun Xie
Neural tube defects (NTDs) represent a developmental disorder of the nervous system that can lead to significant disability in children and impose substantial social burdens. Valproic acid (VPA), a widely prescribed first-line antiepileptic drug for epilepsy and various neurological conditions, has been associated with a 4-fold increase in the risk of NTDs when used during pregnancy. Consequently, urgent efforts are required to identify innovative prevention and treatment approaches for VPA-induced NTDs. Studies have demonstrated that the disruption in the delicate balance between cell proliferation and apoptosis is a crucial factor contributing to NTDs induced by VPA...
December 7, 2023: Acta Biochimica et Biophysica Sinica