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Melatonin in children

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https://www.readbyqxmd.com/read/29766567/melatonin-attenuates-osteosarcoma-cell-invasion-by-suppression-of-c-c-motif-chemokine-ligand-24-through-inhibition-of-the-c-jun-n-terminal-kinase-pathway
#1
Ko-Hsiu Lu, Shih-Chi Su, Chiao-Wen Lin, Yi-Hsien Hsieh, Ya-Chiu Lin, Ming-Hsien Chien, Russel J Reiter, Shun-Fa Yang
Osteosarcoma, with its high metastatic potential, is the most prevalent malignant bone tumor in children and adolescents. Melatonin possesses multiple tumor-suppressing properties for a myriad of tumors, but little is known about the effects of melatonin on osteosarcoma metastasis. In this study, we demonstrated that melatonin elicited very low cytotoxicity and significantly inhibited cellular motility, migration, and invasion in human osteosarcoma U2OS and HOS cells. Moreover, using RNA sequencing technology, we revealed that melatonin repressed C-C motif chemokine ligand 24 (CCL24) gene expression in U2OS cells...
May 16, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29761771/-melatonin-for-children-with-insomnia
#2
Amalie Berring-Uldum, Nanette Marinette Monique Debes, Charlotte Reinhardt Pedersen, Helle Holst
Treatment for insomnia with melatonin (MT) in children and adolescents aged 0-17 years has doubled since 2011. The efficacy and safety profile for MT in children has not been determined. Recent clinical trials indicate, that MT only has a clinical effect on sleep latency, not on total sleep time. Furthermore, it has emerged, that proper sleep hygiene can cure the sleep problem in 50% of the children. Typically, the safety evaluation only entails an unclassified report of adverse events. Two long-term studies investigate and dispel the potential influence of MT on puberty...
May 7, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29720494/melatonin-for-the-management-of-sleep-problems-in-children-with-neurodevelopmental-disorders-a-systematic-review-and-meta-analysis
#3
Ibtihal Siddiq Abdelgadir, Morris A Gordon, Anthony K Akobeng
IMPORTANCE: Children with neurodevelopmental disorders have a higher prevalence of sleep disturbances. Currently there is variation in the use of melatonin; hence, an up-to-date systematic review is indicated to summarise the current available evidence. OBJECTIVE: To determine the efficacy and safety of melatonin as therapy for sleep problems in children with neurodevelopmental disorders. DATA SOURCES AND STUDY SELECTIONS: PubMed, Embase, the Cumulative Index to Nursing and Allied Health Literature and the Cochrane Central Register of Controlled Trials were searched from inception up to January 2018...
May 2, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29706928/repetitive-neonatal-erythropoietin-and-melatonin-combinatorial-treatment-provides-sustained-repair-of-functional-deficits-in-a-rat-model-of-cerebral-palsy
#4
Lauren L Jantzie, Akosua Y Oppong, Fatu S Conteh, Tracylyn R Yellowhair, Joshua Kim, Gabrielle Fink, Adam R Wolin, Frances J Northington, Shenandoah Robinson
Cerebral palsy (CP) is the leading cause of motor impairment for children worldwide and results from perinatal brain injury (PBI). To test novel therapeutics to mitigate deficits from PBI, we developed a rat model of extreme preterm birth (<28 weeks of gestation) that mimics dual intrauterine injury from placental underperfusion and chorioamnionitis. We hypothesized that a sustained postnatal treatment regimen that combines the endogenous neuroreparative agents erythropoietin (EPO) and melatonin (MLT) would mitigate molecular, sensorimotor, and cognitive abnormalities in adults rats following prenatal injury...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29693461/an-update-on-pharmacotherapy-of-autism-spectrum-disorder-in-children-and-adolescents
#5
Ritu Goel, Ji Su Hong, Robert L Findling, Na Young Ji
To date, no medication is proven to be effective in treating core symptoms of autism spectrum disorder (ASD). Psychotropic medications are widely used to target emotional and behavioural symptoms in ASD. This article reviewed evidence for pharmacotherapy, novel therapeutic agents, and Complementary and Alternative Medicine (CAM) in children and adolescents with ASD. Currently, only risperidone and aripiprazole have been approved by the US Food and Drug Administration (FDA) for treatment of irritability associated with ASD in children and adolescents...
April 25, 2018: International Review of Psychiatry
https://www.readbyqxmd.com/read/29656328/human-colostrum-action-against-giardia-lamblia-infection-influenced-by-hormones-and-advanced-maternal-age
#6
Queli Lisiane Castro Pereira, Cristiane de Castro Pernet Hara, Rubian Trindade Silva Fernandes, Danny Laura Gomes Fagundes, Aline do Carmo França-Botelho, Maria Aparecida Gomes, Eduardo Luzía França, Adenilda Cristina Honorio-França
Children are more susceptible to Giardia lamblia infection. Cells and hormones contained in human colostrum have an immunoprotective action against giardiasis, but the effects of advanced maternal age on these components are poorly understood. This study analyzed the colostrum of older women to determine melatonin and cortisol levels besides the participation of these hormones on the functional activity of phagocytes against G. lamblia. Colostrum samples were collected from younger (18 to 35 years old) and older (over 36 years old) lactating women...
April 14, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29609867/circadian-health-differs-between-boys-and-girls-as-assessed-by-non-invasive-tools-in-school-aged-children
#7
Gloria Maria Barraco, Nuria Martínez-Lozano, Claudia Vales-Villamarín, María Del Carmen Blaya, Rafael Rios, Juan Antonio Madrid, Paul Fardy, Marta Garaulet
BACKGROUND & AIMS: Assessment of circadian health is confined to adults. However, understanding circadian status of school-aged children is necessary due to its health implications. The aim was to develop 1) a protocol to assess circadian function in school-aged children by combining the best non-invasive tools previously validated in adults; 2) a score to capture circadian function in children including food timing. This protocol will allow to explore gender differences and to compare the circadian function of school-aged children with adults from the same Mediterranean area...
March 21, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29504270/sensitivity-of-the-circadian-system-to-evening-bright-light-in-preschool-age-children
#8
Lameese D Akacem, Kenneth P Wright, Monique K LeBourgeois
Although the light-induced melatonin suppression response is well characterized in adults, studies examining the dynamics of this effect in children are scarce. The purpose of this study was to quantify the magnitude of evening light-induced melatonin suppression in preschool-age children. Healthy children (n = 10; 7 females; 4.3 ± 1.1 years) participated in a 7-day protocol. On days 1-5, children followed a strict sleep schedule. On day 6, children entered a dim light environment (<15 lux) for 1-h before providing salivary samples every 20- to 30-min from the afternoon until 50-min after scheduled bedtime...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29501372/low-maternal-melatonin-level-increases-autism-spectrum-disorder-risk-in-children
#9
Wiebe Braam, Friederike Ehrhart, Anneke P H M Maas, Marcel G Smits, Leopold Curfs
BACKGROUND: It is assumed that autism spectrum disorder (ASD) is caused by a combination of de novo inherited variation and common variation as well as environmental factors. It often co-occurs with intellectual disability (ID). Almost eight hundred potential causative genetic variations have been found in ASD patients. However, not one of them is responsible for more than 1% of ASD cases. Low melatonin levels are a frequent finding in ASD patients. Melatonin levels are negatively correlated with severity of autistic impairments, it is important for normal neurodevelopment and is highly effective in protecting DNA from oxidative damage...
February 28, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29498667/long-term-melatonin-therapy-for-adolescents-and-young-adults-with-chronic-sleep-onset-insomnia-and-late-melatonin-onset-evaluation-of-sleep-quality-chronotype-and-lifestyle-factors-compared-to-age-related-randomly-selected-population-cohorts
#10
Tom C Zwart, Marcel G Smits, Toine C G Egberts, Carin M A Rademaker, Ingeborg M van Geijlswijk
The extent of continuance of melatonin therapy initiated in pre-pubertal children with chronic sleep onset insomnia (CSOI) was investigated in young adult life. Sleep timing, sleep quality, adverse events, reasons for cessation of therapy, and patient characteristics with regard to therapy regimen, chronotype and lifestyle factors possibly influencing sleeping behavior were assessed. With an online survey using questionnaires (Pittsburgh Sleep Quality Index, Insomnia Severity Index, Morningness-Eveningness Questionnaire, and Munich Chronotype Questionnaire), outcomes were measured and compared with age-related controls...
March 2, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29479245/training-knowledge-attitudes-and-practices-of-canadian-health-care-providers-regarding-sleep-and-sleep-disorders-in-children
#11
Reut Gruber, Evelyn Constantin, Jean Yves Frappier, Robert T Brouillette, Merrill S Wise
Background: Sleep disorders are prevalent in children and are associated with significant comorbidity. Objective: To assess the training, knowledge, attitudes and practices of Canadian health care providers (HCPs) regarding sleep disorders in children. Method: A 42-item survey, designed to collect information on frequency of paediatric sleep disorders-related screening and diagnosis, implementation of evidence-based interventions and related knowledge base, was completed by HCPs...
September 2017: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29404044/formulation-stability-testing-and-analytical-characterization-of-melatonin-based-preparation-for-clinical-trial
#12
Samira Filali, Charlotte Bergamelli, Mamadou Lamine Tall, Damien Salmon, Diane Laleye, Carole Dhelens, Elhadji Diouf, Christine Pivot, Fabrice Pirot
A new institutional clinical trial assessed the improvement of sleep disorders in 40 children with autism treated by immediate-release melatonin formulation in different regimens (0.5 mg, 2 mg, and 6 mg daily) for one month. The objectives of present study were to (i) prepare low-dose melatonin hard capsules for pediatric use controlled by two complementary methods and (ii) carry out a stability study in order to determine a use-by-date. Validation of preparation process was claimed as ascertained by mass uniformity of hard capsules...
August 2017: Journal of Pharmaceutical Analysis
https://www.readbyqxmd.com/read/29389748/clinical-trials-in-autism-spectrum-disorder-evidence-challenges-and-future-directions
#13
Evdokia Anagnostou
PURPOSE OF REVIEW: The purpose of this manuscript is to review the evidence generated by clinical trials of pharmaceuticals in autism spectrum disorder (ASD), describe challenges in the conduct of such trials, and discuss future directions RECENT FINDINGS: Clinical trials in ASD have produced several compounds to adequately support the pharmacological treatment of associated symptom domains: attention deficit hyperactivity disorder (methylphenidate, atomoxetine, and alpha agonists), irritability/aggression (risperidone and aripiprazole), sleep (melatonin), and weight gain associated with atypical antipsychotic use (metformin)...
April 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29379562/a-randomized-clinical-trial-comparing-the-efficacy-of-melatonin-and-amitriptyline-in-migraine-prophylaxis-of-children
#14
Razieh Fallah, Fatemeh Fazelishoroki, Leila Sekhavat
Objective: The aim of the present research was to compare the effectiveness and tolerability of melatonin and amitriptyline in pediatric migraine prevention. Materials & Methods: In a parallel single-blinded randomized clinical trial, 5-15 yr old children with diagnosis of migraine that preventive therapy was indicated in whom and were referred to Pediatric Neurology Clinic of Shahid Sadoughi Medical Sciences University, Yazd-Iran from 2013-2014, were randomly allocated to receive 1 mg/kg amitriptyline or 0...
2018: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29368957/sleep-circadian-rhythms-and-risk-across-health-domains-in-adolescents-with-an-evening-circadian-preference
#15
Michael R Dolsen, James K Wyatt, Allison G Harvey
Sleep and circadian rhythm changes during adolescence contribute to increased risk across emotional, behavioral, cognitive, social, and physical health domains. This study examines if sleep and dim light melatonin onset (DLMO) are related to greater risk in these 5 health domains. Participants were 163 (93 female, age = 14.7 years) adolescents with an evening circadian preference from a study funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Sleep and circadian measures included weekday total sleep time (TST), bedtime, and shut-eye time assessed via sleep diary, the Children's Morningness-Eveningness Preferences scale, and DLMO...
January 25, 2018: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29318587/new-perspectives-on-the-role-of-melatonin-in-human-sleep-circadian-rhythms-and-their-regulation
#16
REVIEW
Nava Zisapel
In mammals, a central circadian clock, located in the suprachiasmatic nuclei (SCN) of the hypothalamus, tunes the innate circadian physiological rhythms to the ambient 24 h light-dark cycle to invigorate and optimize the internal temporal order. The SCN-activated, light-inhibited production of melatonin conveys the message of darkness to the clock and induces night-state physiological functions, for example, sleep/wake blood pressure and metabolism. Clinically meaningful effects of melatonin treatment have been demonstrated in placebo-controlled trials in humans, particularly in disorders associated with diminished or misaligned melatonin rhythms, for example, circadian rhythm-related sleep disorders, jet lag and shift work, insomnia in children with neurodevelopmental disorders, poor (non-restorative) sleep quality, non-dipping nocturnal blood pressure (nocturnal hypertension) and Alzheimer's disease (AD)...
January 10, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29289963/treatment-guidelines-for-circadian-rhythm-sleep-wake-disorders-of-the-polish-sleep-research-society-and-the-section-of-biological-psychiatry-of-the-polish-psychiatric-association-part-ii-diagnosis-and-treatment
#17
REVIEW
Adam Wichniak, Konrad S Jankowski, Michał Skalski, Krystyna Skwarło-Sońta, Jolanta B Zawilska, Marcin Żarowski, Ewa Poradowska, Wojciech Jernajczyk
AIM: Circadian rhythm sleep-wake disorders (CRSWD) are a group of disorders, in which the timing of sleep and wakefulness significantly differs from a patient's expectations or socially acceptable times. The aimof the article is to present the current principles for the diagnosis and treatment of CRSWD in adults and children. METHOD: Guidelines proposed as CRSWD treatment standard are based on the recommendations from the scientific societies involved in the sleep research and medicine...
October 29, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29262470/-sleep-problems-and-the-association-with-the-levels-of-6-sulfatoxymelatonin-in-children-with-autism-spectrum-disorder
#18
P P Han, M Y Zou, X L Yang, X C Liu, S Liang, C H Sun, W Xia, L J Wu
Objective: To identify the prevalence of sleep problems in children with autism spectrum disorder (ASD) and to explore the association with the main melatonin metabolite, 6-sulfatoxymelatonin (6-SM). Method: This was a prospective case-control study. Children with ASD were recruited from Child Development and Behavioral Research Center (CDBRC) of the Harbin Medical University and Harbin Special Education School from October 2015 to April 2017 (ASD group) . Healthy controls were selected from five kindergartens and one primary school in Harbin by the stratified cluster random sampling (control group) ...
December 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29249068/melatonin-as-an-alternative-sedation-method-during-magnetic-resonance-imaging-in-preschool-children-with-musculoskeletal-problems
#19
Agneza Marija Pasini, Josip Marjanović, Goran Roić, Nikola Dukarić, Ana Tripalo Batoš, Zoran Bahtijarević, Alenka Gagro
Magnetic resonance imaging (MRI) in preschool children is often challenging due to excessive motion artifacts. Sedation or general anesthesia (GA) is commonly used to prevent children from moving in the MRI scanner, with increased risk for cardiopulmonary complications and requirement for skilled personnel. Herein, we investigated whether oral melatonin, a natural hormone implicated in circadian rhythm regulation, could be used as an alternative sedation method prior to the MRI in preschool children with musculoskeletal problems...
December 16, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29237331/autism-spectrum-disorder-consensus-guidelines-on-assessment-treatment-and-research-from-the-british-association-for-psychopharmacology
#20
Oliver D Howes, Maria Rogdaki, James L Findon, Robert H Wichers, Tony Charman, Bryan H King, Eva Loth, Gráinne M McAlonan, James T McCracken, Jeremy R Parr, Carol Povey, Paramala Santosh, Simon Wallace, Emily Simonoff, Declan G Murphy
An expert review of the aetiology, assessment, and treatment of autism spectrum disorder, and recommendations for diagnosis, management and service provision was coordinated by the British Association for Psychopharmacology, and evidence graded. The aetiology of autism spectrum disorder involves genetic and environmental contributions, and implicates a number of brain systems, in particular the gamma-aminobutyric acid, serotonergic and glutamatergic systems. The presentation of autism spectrum disorder varies widely and co-occurring health problems (in particular epilepsy, sleep disorders, anxiety, depression, attention deficit/hyperactivity disorder and irritability) are common...
January 2018: Journal of Psychopharmacology
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