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Melatonin in children

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https://www.readbyqxmd.com/read/28921528/practitioner-review-treatment-of-chronic-insomnia-in-children-and-adolescents-with-neurodevelopmental-disabilities
#1
REVIEW
Oliviero Bruni, Marco Angriman, Fabrizio Calisti, Alessandro Comandini, Giovanna Esposito, Samuele Cortese, Raffaele Ferri
BACKGROUND: Sleep disturbances, in particular insomnia, represent a common problem in children with neurodevelopmental disabilities (NDDs). Currently, there are no approved medications for insomnia in children by the US Food and Drug Administration or European Medicines Agency and therefore they are prescribed off-label. We critically reviewed pediatric literature on drugs as well as nonpharmacological (behavioral) interventions used for sleep disturbances in children with NDDs. METHODS: PubMed, Ovid (including PsycINFO, Ovid MEDLINE(®) , and Embase), and Web of Knowledge databases were searched through February 12, 2017, with no language restrictions...
September 18, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28911277/analysis-of-different-melatonin-secretion-patterns-in-children-with-sleep-disorders-melatonin-secretion-patterns-in-children
#2
Ana Checa-Ros, Antonio Muñoz-Hoyos, Antonio Molina-Carballo, Antonio Muñoz-Gallego, Susana Narbona-Galdó, Antonio Jerez-Calero, María Del Carmen Augustín-Morales
The objective of this study was to analyze circadian patterns of urinary 6-sulphatoxymelatonin (aMT6s) excretion in children with primary sleep disorders in comparison with healthy controls. A total of 124 control children and 124 patients (aged 4-14 years) diagnosed with diverse primary sleep disorders were recruited. aMT6s concentrations were measured in diurnal and nocturnal urine, as well as in 24-hour urine. aMT6s levels were significantly higher and showed significantly more evident circadian variations in the control group ( P < ...
October 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28880375/melatonin-does-it-have-utility-in-the-treatment-of-hematologic-neoplasms
#3
REVIEW
Tian Li, Zhi Yang, Shuai Jiang, Wencheng Di, Zhiqiang Ma, Wei Hu, Fulin Chen, Russel J Reiter, Yang Yang
Melatonin, discovered in 1958 in the bovine pineal tissue, is an indoleamine that modulates circadian rhythms and has a wide variety of other functions. Hematologic neoplasms are the leading cause of death in children and adolescents throughout the world. Research has demonstrated that melatonin is a low-toxicity protective molecule against experimental hematological neoplasms, but the mechanisms remain poorly defined. Herein, we provide an introduction to hematologic neoplasms and melatonin, especially as they relate to the actions of melatonin on hematologic carcinogenesis...
September 7, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28874238/-off-label-prescription-of-psychopharmacological-drugs-for-children-and-adolescents
#4
Anne Katrine Pagsberg, Per Hove Thomsen
Despite regulatory initiatives, psychopharmacological treatment of adolescents is challenged by missing trial data on efficacy and safety. In Denmark, an estimated mean off-label prescription rate of 30-40% in clinical child- and adolescent mental health services has been found in recent studies. The lowest rates were found for drugs treating ADHD (2-3%), and the highest for antipsychotics (96%) and melatonin (100%). The use of melatonin is growing, while the use of other psychopharmacological drugs appears to be stabilizing or decreasing, in spite of an increased number of adolescents treated in Danish mental health services...
August 28, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28860773/can-melatonin-prevent-or-improve-metabolic-side-effects-during-antipsychotic-treatments
#5
Maria-Cristina Porfirio, Juliana Paula Gomes de Almeida, Maddalena Stornelli, Silvia Giovinazzo, Diane Purper-Ouakil, Gabriele Masi
In the last two decades, second-generation antipsychotics (SGAs) were more frequently used than typical antipsychotics for treating both psychotic and nonpsychotic psychiatric disorders in both children and adolescents, because of their lower risk of adverse neurological effects, that is, extrapyramidal symptoms. Recent studies have pointed out their effect on weight gain and increased visceral adiposity as they induce metabolic syndrome. Patients receiving SGAs often need to be treated with other substances to counteract metabolic side effects...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28740637/antipsychotic-induced-hyperprolactinemia-in-tourette-syndrome
#6
REVIEW
Judith J G Rath, Marlies E J Deen, Hessel van Houten, Sebastiaan F T M de Bruijn, Joop van Gerven, Dick Mul
For many years, Tourette syndrome (TS) was considered to be a rare disorder, but tics and TS are now recognized as fairly common childhood-onset conditions. Children and adolescents with TS are frequently treated with antipsychotics, either as monotherapy or in combination with psychostimulants, melatonin and selective serotonin reuptake inhibitors (SSRIs). Antipsychotics are most often used in schizophrenia and related psychotic disorders, and in these conditions hyperprolactinemia is one of the most common adverse effects associated with antipsychotics, occurring in 40-50% of patients...
July 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28735262/effectiveness-of-melatonin-in-treating-sleep-problems-in-children-with-intellectual-disability
#7
Irwin Gill, Jacqueline McBrien
No abstract text is available yet for this article.
July 22, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28723825/feasibility-of-conducting-autism-biomarker-research-in-the-clinical-setting
#8
Laura Sices, Katherine Pawlowski, Laura Farfel, Deirdre Phillips, Yamini Howe, David M Cochran, Roula Choueiri, Peter W Forbes, Stephanie J Brewster, Jean A Frazier, Ann Neumeyer, Carolyn Bridgemohan
OBJECTIVE: Recruitment and completion of research activities during regular clinical care has the potential to increase research participation in complex neurodevelopmental disorders. We evaluated the feasibility, and effect on clinical care, of conducting biomarker research within a subspecialty clinical visit for autism spectrum disorder (ASD). METHODS: Children, aged 5 to 10 years, were recruited by providers in ASD clinics at 5 institutions. Biomarkers collected were growth measurements, head circumference, neurologic and dysmorphology examinations, digit ratio (2D:4D) measurement, and platelet serotonin and urinary melatonin sulfate excretion levels...
September 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28540436/premedication-with-melatonin-vs-midazolam-efficacy-on-anxiety-and-compliance-in-paediatric-surgical-patients
#9
Pietro Impellizzeri, Enrica Vinci, Maria Cristina Gugliandolo, Francesca Cuzzocrea, Rosalba Larcan, Tiziana Russo, Maria Rosaria Gravina, Salvatore Arena, Gabriella D'Angelo, Eloisa Gitto, Angela Simona Montalto, Angela Alibrandi, Lucia Marseglia, Carmelo Romeo
Preoperative anxiety is a major problem in paediatric surgical patients. Melatonin has been used as a premedicant agent and data regarding effectiveness are controversial. The primary outcome of this randomized clinical trial was to evaluate the effectiveness of oral melatonin premedication, in comparison to midazolam, in reducing preoperative anxiety in children undergoing elective surgery. As secondary outcome, compliance to intravenous induction anaesthesia was assessed. There were 80 children undergoing surgery randomly assigned, 40 per group, to receive oral midazolam (0...
July 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28529525/melatonin-in-tuberous-sclerosis-complex-analysis-using-modern-mathematical-modeling-methods
#10
Justyna Paprocka, Marek Kijonka, Łukasz Boguszewicz, Maria Sokół
Purpose. The aim of the study was to assess melatonin secretion pattern in children with TSC and to compare it with the secretion patterns in children with and without epilepsy. Material and Methods. Melatonin secretion was measured every three hours using the RIA method in four children with recognized TSC. The parameters of the melatonin secretion models were interpreted and compared with those obtained for the patients with epilepsy (n = 76) and the children from the control, nonepileptic group (n = 36)...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28527085/the-use-of-nutraceutics-in-children-s-and-adolescent-s-headache
#11
R Sangermani, A Boncimino
Nutraceutics are the most used non-pharmacological remedies for migraine's prophylaxis in children and adolescents. Doctors interested in use of nutraceuticals for a complete treatment of children's headache should be adequately informed on this treatments' efficacy and safety. Actually there is a lack of official guidelines about use of nutraceuticals in migraine's prevention in children and adolescent and there are few studies with limited efficacy evidences. The most used nutraceuticals for adolescent's and children's headache prophylaxis are: magnesium, coenzyme Q10, riboflavin, butterbur, feverfew and melatonin...
May 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28505079/melatonin-secretion-is-increased-in-children-with-severe-traumatic-brain-injury
#12
Lucia Marseglia, Gabriella D'Angelo, Sara Manti, Immacolata Rulli, Vincenzo Salvo, Giuseppe Buonocore, Russel J Reiter, Eloisa Gitto
BACKGROUND: Traumatic brain injury (TBI) is a leading cause of death and disability in children. Oxidative stress plays a significant role in brain damage and melatonin exhibits both direct and indirect antioxidant effects. The primary aim of the present study was to evaluate serum melatonin levels in children with severe TBI in comparison to critically ill children admitted to the Pediatric Intensive Care Unit for conditions other than TBI. METHODS: Twenty-four children were evaluated, equally divided into severe TBI and no-TBI...
May 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28503116/melatonin-pharmacology-functions-and-therapeutic-benefits
#13
REVIEW
Sylvie Tordjman, Sylvie Chokron, Richard Delorme, Annaëlle Charrier, Eric Bellissant, Nemat Jaafari, Claire Fougerou
BACKGROUND: Melatonin synchronizes central but also peripheral oscillators (fetal adrenal gland, pancreas, liver, kidney, heart, lung, fat, gut, etc.), allowing temporal organization of biological functions through circadian rhythms (24-hour cycles) in relation to periodic environmental changes and therefore adaptation of the individual to his/her internal and external environment. Measures of melatonin are considered the best peripheral indices of human circadian timing based on an internal 24-hour clock...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28502070/sleep-in-children-with-autism-spectrum-disorder
#14
REVIEW
Margaret C Souders, Stefanie Zavodny, Whitney Eriksen, Rebecca Sinko, James Connell, Connor Kerns, Roseann Schaaf, Jennifer Pinto-Martin
The purposes of this paper are to provide an overview of the state of the science of sleep in children with autism spectrum disorder (ASD), present hypotheses for the high prevalence of insomnia in children with ASD, and present a practice pathway for promoting optimal sleep. Approximately two thirds of children with ASD have chronic insomnia, and to date, the strongest evidence on promoting sleep is for sleep education, environmental changes, behavioral interventions, and exogenous melatonin. The Sleep Committee of the Autism Treatment Network (ATN) developed a practice pathway, based on expert consensus, to capture best practices for screening, identification, and treatment for sleep problems in ASD in 2012...
June 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28449894/young-children-with-down-syndrome-show-normal-development-of-circadian-rhythms-but-poor-sleep-efficiency-a-cross-sectional-study-across-the-first-60-months-of-life
#15
Fabian Fernandez, Casandra C Nyhuis, Payal Anand, Bianca I Demara, Norman F Ruby, Goffredina Spanò, Caron Clark, Jamie O Edgin
OBJECTIVES: To evaluate sleep consolidation and circadian activity rhythms in infants and toddlers with Down syndrome (DS) under light and socially entrained conditions within a familiar setting. Given previous human and animal data suggesting intact circadian regulation of melatonin across the day and night, it was hypothesized that behavioral indices of circadian rhythmicity would likewise be intact in the sample with DS. METHODS: A cross-sectional study of 66 infants and young children with DS, aged 5-67 months, and 43 typically developing age-matched controls...
May 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28444684/-evaluation-and-treatment-of-sleep-problems-in-children-diagnosed-with-attention-deficit-hyperactivity-disorder-an-update-of-the-evidence
#16
REVIEW
M Chamorro, J P Lara, I Insa, M Espadas, J A Alda-Diez
INTRODUCTION: Attention deficit hyperactivity disorder (ADHD) affects approximately 5% of all children and adolescents, and these patients frequently suffer from sleep problems. The association between sleep disorders and ADHD, however, is multifaceted and complex. AIMS: To explore the relationship between sleep disorders and ADHD. DEVELOPMENT: Sleep problems in children with ADHD include altered sleep and specific disorders per se or that may be due to comorbid psychiatric disorders or to the stimulants they receive as treatment for their ADHD...
May 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28391425/safety-tolerability-and-efficacy-of-drugs-for-treating-behavioural-insomnia-in-children-with-attention-deficit-hyperactivity-disorder-a-systematic-review-with-methodological-quality-assessment
#17
REVIEW
Shweta Anand, Henry Tong, Frank M C Besag, Esther W Chan, Samuele Cortese, Ian C K Wong
OBJECTIVE: A large proportion of paediatric patients with attention-deficit/hyperactivity disorder (ADHD) have associated sleep problems which not only affect the child's wellbeing but also impact family functioning. Management of sleep problems is consequently an important aspect of overall ADHD management in paediatric patients. Although some drugs are being used off-label for the management of paediatric insomnia, there is scant clinical evidence supporting their use. Our aim was to identify and assess the quality of published studies reporting the safety, tolerability and efficacy of drugs used for treating behavioural insomnia in children with ADHD...
June 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28365219/study-of-the-efficacy-of-melatonin-for-auditory-brainstem-response-abr-testing-in-children
#18
L Casteil, A Viquesnel, V Favier, N Guignard, C Blanchet, M Mondain
STUDY OBJECTIVE: To evaluate the efficacy of oral melatonin to induce sedation (natural sleep) while measuring auditory brainstem responses (ABR) in children with suspected hearing loss by calculating the ABR success rate with the use of melatonin, the percentage of children in whom sleep was induced by melatonin and the time required to perform complete ABR testing. MATERIAL AND METHODS: Twenty-nine children aged 1 to 6 years were included in this prospective study...
March 29, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28364493/effects-of-melatonin-and-bright-light-treatment-in-childhood-chronic-sleep-onset-insomnia-with-late-melatonin-onset-a-randomized-controlled-study
#19
Annette van Maanen, Anne Marie Meijer, Marcel G Smits, Kristiaan B van der Heijden, Frans J Oort
Study Objectives: Chronic sleep onset insomnia with late melatonin onset is prevalent in childhood, and has negative daytime consequences. Melatonin treatment is known to be effective in treating these sleep problems. Bright light therapy might be an alternative treatment, with potential advantages over melatonin treatment. In this study, we compare the effects of melatonin and bright light treatment with a placebo condition in children with chronic sleep onset insomnia and late melatonin onset...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28331380/classical-conditioning-for-preserving-the-effects-of-short-melatonin-treatment-in-children-with-delayed-sleep-a-pilot-study
#20
Annette van Maanen, Anne Marie Meijer, Marcel G Smits, Frans J Oort
Melatonin treatment is effective in treating sleep onset problems in children with delayed melatonin onset, but effects usually disappear when treatment is discontinued. In this pilot study, we investigated whether classical conditioning might help in preserving treatment effects of melatonin in children with sleep onset problems, with and without comorbid attention deficit hyperactivity disorder (ADHD) or autism. After a baseline week, 16 children (mean age: 9.92 years, 31% ADHD/autism) received melatonin treatment for 3 weeks and then gradually discontinued the treatment...
2017: Nature and Science of Sleep
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