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https://www.readbyqxmd.com/read/27913727/regulated-complex-assembly-safeguards-the-fidelity-of-sleeping-beauty-transposition
#1
Yongming Wang, Diana Pryputniewicz-Dobrinska, Enikö Éva Nagy, Christopher D Kaufman, Manvendra Singh, Steve Yant, Jichang Wang, Anna Dalda, Mark A Kay, Zoltán Ivics, Zsuzsanna Izsvák
The functional relevance of the inverted repeat structure (IR/DR) in a subgroup of the Tc1/mariner superfamily of transposons has been enigmatic. In contrast to mariner transposition, where a topological filter suppresses single-ended reactions, the IR/DR orchestrates a regulatory mechanism to enforce synapsis of the transposon ends before cleavage by the transposase occurs. This ordered assembly process shepherds primary transposase binding to the inner 12DRs (where cleavage does not occur), followed by capture of the 12DR of the other transposon end...
December 1, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27913701/considerations-and-challenges-in-the-icrp-dialogues
#2
T Hanzawa
'Yes I tried to explain, but residents couldn't understand …' This was the title of my presentation at the first International Commission on Radiological Protection (ICRP) dialogue seminar in November 2011 held at the Fukushima Prefectural Government office. The accident at Fukushima Daiichi nuclear power plant was triggered by the tsunami caused by the Great East Japan Earthquake of March 2011. Initially, it was thought that Date city, 50-60 km away from the accident, would be safe, but unfortunately this was not the case due to the direction of the wind at the time of the accident...
December 2, 2016: Annals of the ICRP
https://www.readbyqxmd.com/read/27913545/what-have-we-learned-from-large-population-studies-of-von-willebrand-disease
#3
Robert R Montgomery, Veronica H Flood
Von Willebrand factor (VWF) is a critical regulator of hemostatic processes, including collagen binding, platelet adhesion, and platelet aggregation. It also serves as a carrier protein to normalize plasma factor VIII synthesis, release, and survival. While VWF protein measurements by immunoassay are reasonably comparable between institutions, the measurement of VWF ristocetin cofactor activity (VWF:RCo) has significant variability. Other tests of VWF function, including collagen binding or platelet glycoprotein IIb-IIIa binding, are not universally available, yet these functional defects may cause major bleeding even with normal VWF antigen (VWF:Ag) and VWF:RCo assays...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27913190/synthesis-and-label-free-characterization-of-a-bimolecular-pna-homo-quadruplex
#4
Brunella Pinto, Giulia Rusciano, Stefano D'Errico, Nicola Borbone, Antonio Sasso, Vincenzo Piccialli, Luciano Mayol, Giorgia Oliviero, Gennaro Piccialli
BACKGROUND: G-quadruplex DNA is involved in many physiological and pathological processes. Both clinical and experimental studies on DNA G-quadruplexes are slowed down by their enzymatic instability. In this frame, more stable chemically modified analogs are needed. METHODS: The bis-end-linked-(gggt)2 PNA molecule (BEL-PNA) was synthesized using in solution and solid phase synthetic approaches. Quadruplex formation was assessed by circular dichroism (CD) and surface enhanced Raman scattering (SERS)...
November 29, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27911427/-modern-approach-to-early-diagnosis-and-pathogenetic-treatment-of-diabetic-retinopathy
#5
I V Vorob'eva
AIM: To improve the approach to pathogenetic treatment of diabetic retinopathy (DR) through early diagnosis and a new method for predicting disease progression. MATERIAL AND METHODS: The study enrolled 330 type 2 diabetes patients with DR (660 eyes), of whom women constituted 64.6%, men - 35.4%. The mean patient age was 62.3±2.3 years. Three groups were formed: the controls - 30 healthy volunteers (60 eyes) and 30 type 2 diabetes patients without ocular involvement (DR 0, 60 eyes); group 1 - 30 type 2 diabetes patients with DR I but no diabetic macular edema (DR I without DME, 60 eyes) that were treated with calcium dobesilate; group 2 - 240 type 2 diabetes patients, who had diabetic retinopathy of different stages (DR I, II, or III with DME, 480 eyes) and received laser retinal photocoagulation (LRP)...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27911418/synthesis-and-characterization-of-fe-doped-aluminosilicate-nanotubes-with-enhanced-electron-conductive-properties
#6
Ehsan Shafia, Serena Esposito, Elnaz Bahadori, Marco Armandi, Maela Manzoli, Barbara Bonelli
The goal of the protocol is to synthesize Fe-doped aluminosilicate nanotubes of the imogolite type with the formula (OH)3Al2-xFexO3SiOH. Doping with Fe aims at lowering the band gap of imogolite, an insulator with the chemical formula (OH)3Al2O3SiOH, and at modifying its adsorption properties towards azo-dyes, an important class of organic pollutants of both wastewater and groundwater. Fe-doped nanotubes are obtained in two ways: by direct synthesis, where FeCl3 is added to an aqueous mixture of the Si and Al precursors, and by post-synthesis loading, where preformed nanotubes are put in contact with a FeCl3•6H2O aqueous solution...
November 15, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27910908/larval-diet-affects-mosquito-development-and-permissiveness-to-plasmodium-infection
#7
Inbar Linenberg, George K Christophides, Mathilde Gendrin
The larval stages of malaria vector mosquitoes develop in water pools, feeding mostly on microorganisms and environmental detritus. Richness in the nutrient supply to larvae influences the development and metabolism of larvae and adults. Here, we investigated the effects of larval diet on the development, microbiota content and permissiveness to Plasmodium of Anopheles coluzzii. We tested three fish diets often used to rear mosquitoes in the laboratory, including two pelleted diets, Dr. Clarke's Pool Pellets and Nishikoi Fish Pellets, and one flaked diet, Tetramin Fish-Flakes...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910821/reply-to-comment-on-imaging-of-prompt-gamma-rays-emitted-during-delivery-of-clinical-proton-beams-with-a-compton-camera-feasibility-studies-for-range-verification
#8
Jerimy C Polf, Stephen Avery, Dennis S Mackin, Sam Beddar
A reply is provided to the points raised in the comment by Dr Sitek (2016 Phys. Med. Biol. 61 8941) on Polf et al (2015 Phys. Med. Biol. 60 7085).
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27910575/measurement-of-the-internal-magnetic-fluctuation-by-the-transport-of-runaways-on-j-text
#9
Z Y Chen, D W Huang, R H Tong, W Yan, Y N Wei, T K Ma, Z H Jiang, X Q Zhang, Z P Chen, Z J Yang, G Zhuang
The measurement of internal magnetic fluctuation is important for the study of transport in tokamak plasmas. The runaway electron transport induced by the sawtooth crash can be used to obtain the internal magnetic fluctuation. Inversed sawtooth-like activities on hard x-ray (HXR) fluxes following sawtooth activities were observed after the application of electrode biasing on J-TEXT tokamak. The runaway diffusion coefficient Dr is deduced to be about 30 m(2)/s according to the time delay of HXR flux peaks to the sawtooth crashes...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910236/ase-nsw-meeting-17-th-august-2016
#10
Dr Mehdi Rahimi
No abstract text is available yet for this article.
December 2016: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/27910207/editorial-comment-from-dr-ibrahim-to-testicular-sperm-extraction-for-patients-with-spinal-cord-injury-related-anejaculation-a-single-center-experience
#11
Emad Ibrahim
No abstract text is available yet for this article.
December 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27910085/sprint-fidelis-implantable-cardioverter-defibrillators-lead-patient-management-and-survival-single-center-study
#12
Marcin Grabowski, Jakub Kosma Rokicki, Sylwia Gajda, Łukasz Januszkiewicz, Andrzej Cacko, Przemysław Stolarz, Grzegorz Opolski
BACKGROUND: Over the last several years significant rises in the use of implanted cardioverter-defibrillators (ICD) have also resulted in a number of associated complications. This number includes lead failure. Sprint Fidelis ICD lead (SF) is regarded as a lead with elevated failure risk. Every center acting in accordance with the guidelines should observe patients more thoroughly especially with recalled leads and run a registry of their follow-up. The aim of the present research was to observe patients with SF leads (types 6948, 6949) from a single implantation center...
December 2, 2016: Cardiology Journal
https://www.readbyqxmd.com/read/27909878/new-associate-editor-prof-dr-j-sehouli-for-the-section-gynecologic-oncology
#13
Jalid Sehouli
No abstract text is available yet for this article.
December 1, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27909871/nap-interferes-with-hypoxia-inducible-factors-and-vegf-expression-in-retina-of-diabetic-rats
#14
Agata Grazia D'Amico, Grazia Maugeri, Claudio Bucolo, Salvatore Saccone, Concetta Federico, Sebastiano Cavallaro, Velia D'Agata
The retinal microvascular damage is a complication of diabetic retinopathy (DR). Hyperglycemia and hypoxia are responsible of aberrant vessel's proliferation. The cellular response to hypoxia is mediated through activation of hypoxia-inducible factors (HIFs). Among these, HIF-1α modulates expression of its target gene, VEGF, whose upregulation controls the angiogenic event during DR development. In a previous study, we have demonstrated that a small peptide, NAP, is able to protect retina from hyperglycemic insult...
December 1, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27909485/supraventricular-tachycardia-with-irregular-ventricular-atrial-intervals-and-ventriculo-atrial-block
#15
Prof Dr Murat Sucu, Prof Dr Vedat Davutoglu, Dr Esra Polat
The patient was a 68-year-old female with recurrent paroxysmal, regular narrow QRS complex tachycardia. We observed complete VA conduction block, during tachycardia in our patient. A characteristic feature of our patient is the noticeable irregular atrial and ventricular rates. We considered that possible mechanism of this tachycardia was atrioventricular nodal reentrant tachycardia (AVNRT) with retrograde complete type block in the upper common pathway.
February 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909484/lyme-arrhythmia-in-an-avid-golfer-a-diagnostic-challenge-and-a-therapeutic-dilemma
#16
Ujjwal Rastogi, Dr Nidhi Kumars
Lyme disease is a multisystem disorder affecting dermatologic, cardiac, nervous and musculoskeletal systems. Cardiac manifestations occur in about 5% of Lyme infections and stem from the involvement of the cardiac conduction system, resulting in varying degrees of sino-atrioventricular block. Occasionally, Lyme infection may also present with myopericarditis. Unlike isolated conduction node disease, myocardial involvement presents a great diagnostic and therapeutic dilemma for the physician. We report the case of a 68 year-old male cardiologist who presented with new onset exertional dyspnea and palpitations...
February 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909470/clinical-and-economic-implications-of-af-related-stroke
#17
REVIEW
Dr Ali N Ali, Dr Ahmed Abdelhafiz
A major cause of morbidity and mortality among patients with atrial fibrillation (AF) relates to the increased risk of stroke. The burden of illness that AF imparts on stroke is likely to increase with our aging populations and increasingly sophisticated cardiac monitoring techniques. Understanding the clinical and economic differences between AF related ischaemic stroke and non-AF related stroke is important if we are to improve future cost effectiveness analyses of potential preventative treatments, but also to help educate clinical and policy decision makers on use or availability of treatments to prevent AF related stroke...
February 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909469/value-of-the-wearable-cardioverter-defibrillator-wcd-as-a-bridging-therapy-before-implantation-of-a-cardioverter-defibrillator-icd
#18
REVIEW
Priv- Doz, Dr Johannes Sperzel
Wearable cardioverter defibrillators (WCD), initially available in 2002, have recently experienced more routine use in many institutions as a means of preventing sudden cardiac death (SCD) prior to implantable cardioverter defibrillator (ICD) evaluation or implantation. WCD differ from ICD by their noninvasive nature, making them well suited for patient populations who have a chance for significant cardiac recovery (such as after an acute myocardial infarction). Despite their noninvasive nature, WCD treatment of sustained ventricular tachyarrhythmias is highly successful...
February 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909146/dr-elsaman-et-al-reply
#19
Ahmed Elsaman, Ahmed Radwan, Walaa Mohammed, Sarah Ohrndorf
No abstract text is available yet for this article.
December 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27908554/apolipoprotein-a-i-and-b-and-subjective-global-assessment-relationship-can-reflect-lipid-defects-in-diabetic-retinopathy
#20
Yashodhara Sharma, Sandeep Saxena, Arvind Mishra, Anita Saxena, Shankar Madhav Natu
OBJECTIVE: Elevated lipid levels increase complications of diabetic retinopathy (DR). Uncontrolled diabetes increases these complications and causes unintentional weight loss, indicating an apparently normal body mass index (BMI). Thus, it is easy to assume that patients with DR and a normal BMI have optimal lipid status. Apolipoprotein (Apo) A-I and Apo B levels differentially indicate serum lipid status in DR. Subjective Global Assessment (SGA) scores are associated with DR status. If SGA scores and serum Apo A-I and B levels are found to be interrelated, their relationship can reflect lipid defects in patients with DR despite apparently normal BMI...
January 2017: Nutrition
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