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https://www.readbyqxmd.com/read/29161518/sexual-functioning-in-experienced-meditators
#1
Ms Iulia Dascalu, Dr Lori A Brotto
Given evidence of the benefits of mindfulness for women's sexual difficulties, we investigated the relationship between meditation experience and women's sexual function. Women (n = 451) answered online survey questions about meditation experience, sexual function and desire, interoceptive awareness, health and mood. Women who meditated scored higher than non-meditators on measures of sexual function and desire, however there was no significant correlation between frequency/length of meditation experience and either of these domains...
November 21, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/29161450/response-to-letter-by-dr-champion
#2
Nancy Dawson
No abstract text is available yet for this article.
November 17, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29161438/response-to-letter-to-editor-from-dr-o-m-p-jolobe
#3
H Matsuura, Y Yamaji
No abstract text is available yet for this article.
October 30, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29161345/an-interview-with-dr-sudhansu-k-dey
#4
Romana A Nowak
No abstract text is available yet for this article.
November 17, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29161267/sugar-industry-sponsorship-of-germ-free-rodent-studies-linking-sucrose-to-hyperlipidemia-and-cancer-an-historical-analysis-of-internal-documents
#5
Cristin E Kearns, Dorie Apollonio, Stanton A Glantz
In 1965, the Sugar Research Foundation (SRF) secretly funded a review in the New England Journal of Medicine that discounted evidence linking sucrose consumption to blood lipid levels and hence coronary heart disease (CHD). SRF subsequently funded animal research to evaluate sucrose's CHD risks. The objective of this study was to examine the planning, funding, and internal evaluation of an SRF-funded research project titled "Project 259: Dietary Carbohydrate and Blood Lipids in Germ-Free Rats," led by Dr. W...
November 2017: PLoS Biology
https://www.readbyqxmd.com/read/29161036/visible-light-activated-asymmetric-%C3%AE-c-h-functionalization-of-acceptor-substituted-ketones-with-1-2-dicarbonyl-compounds
#6
Jiajia Ma, Anthony R Rosales, Xiaoqiang Huang, Klaus Harms, Radostan Riedel, Olaf Wiest, Eric Meggers
We report a visible-light-activated asymmetric β-C(sp(3))-H functionalization of 2-acyl imidazoles and 2-acylpyridines with 1,2-dicarbonyl compounds (typically α-ketoesters) catalyzed by a tailored stereogenic-at-rhodium Lewis acid catalyst. The C-C bond formation products are obtained in high yields (up to 99%) and with excellent stereoselectivities (up to >20:1 dr and up to >99% ee). Experimental and computational studies support a mechanism in which a photoactivated Rh-enolate transfers a single electron to the 1,2-dicarbonyl compound followed by proton transfer and a subsequent stereocontrolled radical-radical recombination...
November 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29160569/reconstruction-of-bladder-function-and-prevention-of-renal-deterioration-by-means-of-end-to-side-neurorrhaphy-in-rats-with-neurogenic-bladder
#7
Yun Long Li, Jian Jun Wen, Yi Bo Wen, Xiang Fei He, Jun Wei Wu, Yan Wei Li, Zhong Jiang Han, Jin Jin Feng, Shao Hua Yan, Shou Lin Li, John Pfa Heesakkers, Wan Sheng Gao, Jian Guo Wen
AIMS: To investigate the feasibility of restoring bladder function and prevention of renal deterioration by neurorrhaphy in rats with neurogenic bladder (NB). METHODS: Forty-two rats were assigned to the end-to-side nerve coaptation group (ECG, n = 16), no nerve coaptation group (NCG, n = 16), and control group (CG, n = 10). In the ECG, the left ventral root (VR) and dorsal root (DR) of L6 and S1 were transected, and the distal stump of L6VR was sutured to the lateral face of L4VR...
November 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29159688/correction-to-sphenopalatine-ganglion-block-in-the-management-of-chronic-headaches
#8
Jeffrey Mojica, Bi Mo, Andrew Ng
The original version of this article contains an error in an author's first name. The spelling of Dr. Mojica's first name should read "Jeffrey" instead of "Jeffery."
November 20, 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29159448/laudation-for-dr-alexander-berghaus
#9
H M T Foda
No abstract text is available yet for this article.
November 20, 2017: HNO
https://www.readbyqxmd.com/read/29158134/the-inflammasome-pathway-is-amplified-and-perpetuated-in-an-autocrine-manner-through-connexin43-hemichannel-mediated-atp-release
#10
Odunayo O Mugisho, Colin R Green, Dan T Kho, Jie Zhang, E Scott Graham, Monica L Acosta, Ilva D Rupenthal
BACKGROUND: Connexin43 hemichannels have been implicated in many inflammatory diseases including diabetic retinopathy (DR). Particularly, hemichannel-mediated ATP release has been associated with inflammasome pathway activation. Using an in vitro cell culture model, we evaluated hemichannel roles in response to inflammatory cytokines under high glucose (HG) conditions and propose a mechanism by which a connexin43 hemichannel-mediated autocrine ATP feedback loop augments chronic inflammatory disease...
November 17, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29158005/1-25-oh-2d3-induced-apoptosis-of-human-hepatocellular-carcinoma-cells-in-vitro-and-inhibited-their-growth-in-a-nude-mouse-xenograft-model-by-regulating-histone-deacetylase-2
#11
Jian Huang, Guozhen Yang, Yunzhu Huang, Shu Zhang
The aim of this study was to evaluate the effects of 1,25(OH)2D3 on the apoptosis of human hepatocellular carcinoma (HCC) cells. The effects of 1,25(OH)2D3 on the proliferation and apoptosis of human HCC cells by regulating histone deacetylase 2 (HDAC2) were assessed by MTT assay and flow cytometry. The effects of 1,25(OH)2D3 on the expressions of related proteins in the apoptosis pathway by regulating HDAC2 as well as the mechanism were studied by Western blot and quantitative real-time PCR. A nude mouse model of HCC xenograft was established...
November 17, 2017: Biochimie
https://www.readbyqxmd.com/read/29157445/an-ensemble-deep-learning-based-approach-for-red-lesion-detection-in-fundus-images
#12
José Ignacio Orlando, Elena Prokofyeva, Mariana Del Fresno, Matthew B Blaschko
BACKGROUND AND OBJECTIVES: Diabetic retinopathy (DR) is one of the leading causes of preventable blindness in the world. Its earliest sign are red lesions, a general term that groups both microaneurysms (MAs) and hemorrhages (HEs). In daily clinical practice, these lesions are manually detected by physicians using fundus photographs. However, this task is tedious and time consuming, and requires an intensive effort due to the small size of the lesions and their lack of contrast. Computer-assisted diagnosis of DR based on red lesion detection is being actively explored due to its improvement effects both in clinicians consistency and accuracy...
January 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29157346/dr-sherman-vinograd-and-his-contributions-to-the-skylab-medical-program
#13
Mark R Campbell
No abstract text is available yet for this article.
December 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29157080/secretory-autophagy-holds-the-key-to-lysozyme-secretion-during-bacterial-infection-of-the-intestine
#14
Elizabeth Delorme-Axford, Daniel J Klionsky
In 2013, Dr. Lora Hooper and colleagues described the induction of antibacterial macroautophagy/autophagy in intestinal epithelial cells as a cytoprotective host defense mechanism against invading Salmonella enterica serovar Typhimurium (S. Typhimurium). Canonical autophagy functions in a primarily degradative capacity to safeguard cells and ensure survival during stress conditions, including pathogen infection. In contrast, secretory autophagy has emerged as an alternative nondegradative mechanism for cellular trafficking and unconventional protein secretion...
November 20, 2017: Autophagy
https://www.readbyqxmd.com/read/29157077/how-does-early-maternal-separation-and-chronic-stress-in-adult-rats-affect-the-immunoreactivity-of-serotonergic-neurons-within-the-dorsal-raphe-nucleus
#15
Antonella Pollano, Verónica Trujillo, Marta M Suárez
Vulnerability to emotional disorders like depression derives from interactions between early and late environments, including stressful conditions. The serotonin (5HT) system is strongly affected by stress and chronic unpredictable stress can alter the 5HT system. We evaluated the distribution of active serotonergic neurons in the dorsal raphe nucleus (DR) through immunohistochemistry in maternally separated and chronically stressed rats treated with an antidepressant, tianeptine, whose mechanism of action is still under review...
November 20, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29156889/chemotherapy-induced-oral-mucositis-prevention-is-possible
#16
E Una Cidon
BACKGROUND: Oral mucositis (OM) is an inflammation of the oral mucosa which occurs in 20-40% of patients receiving conventional chemotherapy (CM). Many different substances have been used separately to treat or prevent OM but no standard procedure has been settled as definitive. We conducted a prospective study to examine whether rinses with a mixture of soluble prednisolone, nystatin and salt water applied before the expected OM appears, would reduce the incidence of grade 2-3 OM in subsequent cycles of CM...
November 3, 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29156536/a-review-on-exudates-detection-methods-for-diabetic-retinopathy
#17
REVIEW
Shilpa Joshi, P T Karule
The presence of exudates on the retina is the most characteristic symptom of diabetic retinopathy. As exudates are among early clinical signs of DR, their detection would be an essential asset to the mass screening task and serve as an important step towards automatic grading and monitoring of the disease. Reliable identification and classification of exudates are of inherent interest in an automated diabetic retinopathy screening system. Here we review the numerous early studies that used for automatic exudates detection with the aim of providing decision support in addition to reducing the workload of an ophthalmologist...
November 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29155071/structural-rearrangements-of-the-rna-polymerase-iii-machinery-during-trna-transcription-initiation
#18
REVIEW
Ewan Phillip Ramsay, Alessandro Vannini
RNA polymerase III catalyses the synthesis of tRNAs in eukaryotic organisms. Through combined biochemical and structural characterisation, multiple auxiliary factors have been identified alongside RNA Polymerase III as critical in both facilitating and regulating transcription. Together, this machinery forms dynamic multi-protein complexes at tRNA genes which are required for polymerase recruitment, DNA opening and initiation and elongation of the tRNA transcripts. Central to the function of these complexes is their ability to undergo multiple conformational changes and rearrangements that regulate each step...
November 15, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29155023/therapy-related-myeloid-neoplasm-in-an-18-year-old-boy-with-b-lymphoblastic-leukemia
#19
Xin Qing, Eduard Panosyan, ChangjunYue, Ping Ji, Moran Gotesman, Samuel French, Junchao Cai
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. Acute myeloid leukemia or myelodysplastic syndrome during the course of ALL is a rare entity. Some of these cases are therapy-related while the others occur due to lineage switch. The correct diagnosis relies on comparing the immunophenotypes and cytogenetic/molecular alterations of the myeloid neoplasm and the ALL. We present the clinical, pathologic and cytogenetic features of a case of an 18-year-old male with prior treatment for B-lymphoblastic leukemia (B-ALL) who developed therapy-related myeloid neoplasm (t-MN) 4-5years after his initial diagnosis of B-ALL...
November 16, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29154404/diabetes-news
#20
Ann M Carracher, Payal H Marathe, Kelly L Close
The 20th annual Diabetes Canada Professional Conference took place in November 2017 in Edmonton, Alberta, Canada, featuring Dr Daniel Drucker on 30 years of incretin biology research and Dr David Matthews on implications of the Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes (CANVAS) trial,(1) among other sessions.
November 20, 2017: Journal of Diabetes
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