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https://www.readbyqxmd.com/read/28534863/the-clinical-course-of-patients-with-preschool-manifestation-of-type-1-diabetes-is-independent-of-the-hla-dr-dq-genotype
#1
Christina Reinauer, Joachim Rosenbauer, Christina Bächle, Christian Herder, Michael Roden, Sian Ellard, Elisa De Franco, Beate Karges, Reinhard W Holl, Jürgen Enczmann, Thomas Meissner
INTRODUCTION: Major histocompatibility complex class II genes are considered major genetic risk factors for autoimmune diabetes. We analysed Human Leukocyte Antigen (HLA) DR and DQ haplotypes in a cohort with early-onset (age < 5 years), long term type 1 diabetes (T1D) and explored their influence on clinical and laboratory parameters. METHODS: Intermediate resolution HLA-DRB1, DQA1 and DQB1 typing was performed in 233 samples from the German Paediatric Diabetes Biobank and compared with a local control cohort of 19,544 cases...
May 19, 2017: Genes
https://www.readbyqxmd.com/read/28534786/evolutionary-computing-enriched-computer-aided-diagnosis-system-for-diabetic-retinopathy-a-survey
#2
Romany Mansour
The alterations caused due to diabetes mellitus results into significant micro-vasculature that eventually causes diabetic retinopathy (DR) that keeps on increasing as per time and eventually causes complete vision loss. Identifying subtle variations in morphological changes in retinal blood vessels, optic disk, exudates, micro-aneurysms, hemorrhage etc is complicate and requires robust computer aided diagnosis (CAD) system so as to enable earlier and efficient DR diagnosis practices. In majority of the existing CAD systems, the need of functional enhancement has been realized time by time to ensure accurate and time efficient DR...
May 17, 2017: IEEE Reviews in Biomedical Engineering
https://www.readbyqxmd.com/read/28534764/traveling-to-angola-to-validate-a-paper-based-sickle-cell-disease-test
#3
Nathaniel Z Piety
When I started graduate school, I had no idea that it would take me halfway around the world to a small clinic in Cabinda, Angola, but I'm glad that it did. Since 2011, I have been a part of the team of engineers and clinicians, led by Dr. Sergey Shevkoplyas, working to develop a simple, low-cost, paper-based test for sickle cell disease-a common inherited blood disorder that is most prevalent in sub-Saharan Africa (Figure S1).
May 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28534639/asymmetric-synthesis-of-functionalized-tricyclic-chromanes-via-an-organocatalytic-triple-domino-reaction
#4
Mukesh Kumar, Pankaj Chauhan, Arto Valkonen, Kari Rissanen, Dieter Enders
A highly stereoselective triple domino reaction for the synthesis of functionalized tricyclic chromane scaffolds has been developed. A secondary amine-catalyzed domino Michael/Michael/aldol condensation reaction between aliphatic aldehydes, nitro-chromenes, and α,β-unsaturated aldehydes leads to the formation of synthetically important tricyclic chromanes bearing four contiguous stereogenic centers including a tetrasubstituted carbon in good yields (20-66%) and excellent stereoselectivities (>20:1 dr and >99% ee)...
May 23, 2017: Organic Letters
https://www.readbyqxmd.com/read/28533307/sox11-promotes-tumor-protective-microenvironment-interactions-through-cxcr4-and-fak-regulation-in-mantle-cell-lymphoma
#5
Patricia Balsas, Jara Palomero, Álvaro Eguileor, Marta Leonor Rodriguez, Maria Carmela Vegliante, Ester Planas-Rigol, Marta Sureda-Gómez, Maria C Cid, Elias Campo, Virginia Amador
SOX11 overexpression in Mantle Cell Lymphoma (MCL) has been associated with more aggresive behavior and worse outcome. However, SOX11 oncogenic pathways driving MCL tumor progression are poorly known. Here, we demonstrate that SOX11 binds to regulatory regions of two important genes for microenvironment-signals in cancer, (C-X-C motif) chemokine receptor 4 (CXCR4) and PTK2 (encoding for focal adhesion kinase (FAK)). Moreover, SOX11-positive xenograft and human primary MCL tumors overexpress cell migration and stromal stimulation gene signatures compared to their SOX11-negative counterparts...
May 22, 2017: Blood
https://www.readbyqxmd.com/read/28533296/glp-1r-as-a-target-for-the-treatment-of-diabetic-retinopathy-friend-or-foe
#6
Rafael Simó, Cristina Hernández
Glucagon-like peptide 1 receptor (GLP-1R) agonists are increasingly being used as treatment for type 2 diabetes. Since the U.S. Food and Drug Administration published recommendations about the cardiovascular safety of new antidiabetes therapies for treating type 2 diabetes in 2008, the results of two outstanding clinical trials using GLP-1R agonists addressing this issue (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results-A Long Term Evaluation [LEADER] and Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 Diabetes [SUSTAIN-6]) have been published...
June 2017: Diabetes
https://www.readbyqxmd.com/read/28533056/white-matter-damage-after-traumatic-brain-injury-a-role-for-damage-associated-molecular-patterns
#7
REVIEW
Molly Braun, Kumar Vaibhav, Nancy M Saad, Sumbul Fatima, John R Vender, Babak Baban, Md Nasrul Hoda, Krishnan M Dhandapani
Traumatic brain injury (TBI) is a leading cause of mortality and long-term morbidity worldwide. Despite decades of pre-clinical investigation, therapeutic strategies focused on acute neuroprotection failed to improve TBI outcomes. This lack of translational success has necessitated a reassessment of the optimal targets for intervention, including a heightened focus on secondary injury mechanisms. Chronic immune activation correlates with progressive neurodegeneration for decades after TBI; however, significant challenges remain in functionally and mechanistically defining immune activation after TBI...
May 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28532883/a-critical-overview-of-the-current-myofascial-pain-literature-march-2017
#8
REVIEW
Jan Dommerholt, Rob Grieve, Todd Hooks, Michelle Finnegan
After two years of having contributed to this overview series of articles, we sadly say goodbye to Dr. Rob Grieve. We would like to thank Dr. Grieve for his insightful contributions and analyses of the myofascial pain literature. Dr. Grieve would have preferred to continue, but his many university and research responsibilities had to take priority. We are looking forward to reviewing his future research endeavors in this article. We are pleased that Dr. Li-Wei Chou, MD, PhD has agreed to replace Dr. Grieve and join our team...
April 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28532613/the-practice-of-evidence-based-medicine-involves-the-care-of-whole-persons
#9
W Scott Richardson
In this issue of the Journal, Dr. Fava posits that evidence-based medicine (EBM) was bound to fail. I share some of the concerns he expresses, yet I see more reasons for optimism. Having been on rounds with both Drs. Engel and Sackett, I reckon they would have agreed more than they disagreed. Their central teaching was the compassionate and well-informed care of sick persons. The model that emerged from these rounds was that patient care could be both person-centered and evidence-based, that clinical judgment was essential to both, and the decisions could and should be shared...
April 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28531813/immunomodulatory-function-of-whole-human-umbilical-cord-derived-mesenchymal-stem-cells
#10
Hao Zhang, Yanling Tao, Haihui Liu, Saisai Ren, Bin Zhang, Hu Chen
Bone marrow derived mesenchymal stem cells (MSCs) play a critical role in immune modulation. However, immunomodulatory function of whole human umbilical cord derived mesenchymal stem cells (UC-MSCs) remains unclear. In this study, UC-MSCs were separated from whole umbilical cord using a single enzyme digestion. UC-MSCs (CD73(+), CD90(+), CD105(+), and CD34(-), CD45(-), HLA-DR(-)) were differentiated into adipocytes, osteocytes and chondrocytes in vitro under specific stimulatory environments. UC-MSCs suppressed umbilical cord blood lymphocyte proliferation stimulated by mitogen, and ELISA showed that the secretion of INF-γ was downregulated, and the secretion of IL-4 was upregulated, with CD8(+) T cells markedly decreased and CD4(+) T cells changed lightly...
May 19, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28530302/a-dynamic-kinetic-asymmetric-transfer-hydrogenation-cyclization-tandem-reaction-an-easy-access-to-chiral-3-4-dihydro-2h-pyran-carbonitriles
#11
Dongsong Zheng, Qiankun Zhao, Xiaoying Hu, Tanyu Cheng, Guohua Liu, Wei Wang
A chiral (mesitylene)RuCl(monosulfonated diamine) catalysed dynamic kinetic resolution (DKR)-asymmetric transfer hydrogenation (ATH) process is developed for highly enantio- (up to 99% ee) and diastereo- (up to 98 : 2 dr) selective reduction of challenging racemic α-aryl-γ-keto malononitriles. A spontaneous cyclization reaction of the hydrogenation products delivers a cascade process for efficient synthesis of useful enantioenriched 3,4-dihydro-2H-pyran-carbonitriles.
May 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28529935/modified-fisher-method-for-unilateral-cleft-lip-report-of-cases
#12
Hui Young Kim, Joonhyoung Park, Ming-Chih Chang, In Seok Song, Byoung Moo Seo
BACKGROUND: Rehabilitation of normal function and form is essential in cleft lip repair. In 2005, Dr. David M. Fisher introduced an innovative method, named "an anatomical subunit approximation technique" in unilateral cleft lip repair. According to this method, circumferential incision along the columella on cleft side of the medial flap is continued to the planned top of the Cupid's bow in straight manner, which runs parallel to the unaffected philtral ridge. Usually, small inlet incision is needed to lengthen the medial flap...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28529511/characterization-of-cd4-t-cell-epitopes-of-infliximab-and-rituximab-identified-from-healthy-donors
#13
Moustafa Hamze, Sylvain Meunier, Anette Karle, Abdelaziz Gdoura, Amélie Goudet, Natacha Szely, Marc Pallardy, Franck Carbonnel, Sebastian Spindeldreher, Xavier Mariette, Corinne Miceli-Richard, Bernard Maillère
The chimeric antibodies anti-CD20 rituximab (Rtx) and anti-TNFα infliximab (Ifx) induce antidrug antibodies (ADAs) in many patients with inflammatory diseases. Because of the key role of CD4 T lymphocytes in the initiation of antibody responses, we localized the CD4 T cell epitopes of Rtx and Ifx. With the perspective to anticipate immunogenicity of therapeutic antibodies, identification of the CD4 T cell epitopes was performed using cells collected in healthy donors. Nine T cell epitopes were identified in the variable chains of both antibodies by deriving CD4 T cell lines raised against either Rtx or Ifx...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28529251/image-quality-and-clinical-usefulness-of-ray-summation-image-reconstructed-from-ct-data-compared-with-digital-radiography
#14
Shogo Suzuki, Katsuhiro Ichikawa, Shigeru Tamaki
Ray-summation (raysum) images reconstructed from computed tomography (CT) volume data resemble digital radiography (DR) images. Therefore, they have a potential to be used instead of DR images.The aim of this study was to compare the physical image quality evaluated by signal-difference-to-noise ratio (SDNR) and clinical usefulness between raysum and DR images. We employed an oval water phantom simulating adult abdomen for image quality measurement. Raysum images were reconstructed from CT volume data using an assumed x-ray quality of 70 keV...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/28529237/-i-life-in-the-year-6000-i-by-santiago-ram%C3%A3-n-y-cajal-a-translation-of-an-unpublished-vacation-story
#15
Andrew W Perez
In 2006, Laura Otis provided the first English translation of five short stories written by the Spanish artist, neuroscientist, and histologist Santiago Ramón y Cajal. These stories, originally published in 1905 by Cajal under the pseudonym "Dr. Bacteria," are called "Cuentos de vacaciones: narraciones seudocientíficas" or "Vacation Stories: Pseudoscientific Tales." In 1973, a version of Cajal's manuscript "La vida en el año 6000" (Life in the year 6000) was revealed. It had remained in manuscript form since the mid-1880s and appears to be a draft of one of Cajal's unpublished "Cuentos de vacaciones...
2017: Literature and Medicine
https://www.readbyqxmd.com/read/28529157/protective-treatments-and-their-target-retinal-ganglion-cells-in-diabetic-retinopathy
#16
REVIEW
Jing Zhang, Rong Liu, Hong-Yu Kuang, Xin-Yuan Gao, Hao-Ling Liu
Diabetic retinopathy(DR)is one of the complications of diabetes which could cause severe vision loss. Retinal ganglion cell(RGC)injury has been confirmed prior to micro-vascular damage. Over the past few decades, a number of animal and clinical studies have confirmed that RGC impairment leads to an early deterioration of vision in DR. Inhibition of aldose reductase (AR), advanced glycation end product (AGE), oxidative stress, glutamate toxicity, and an inflammatory response may play important roles in protecting RGCs in DR...
May 18, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28528684/clinical-studies-in-humans-targeting-the-various-components-of-the-igf-system-show-lack-of-efficacy-in-the-treatment-of-cancer
#17
REVIEW
Anastassios Philippou, Panagiotis F Christopoulos, Dr Michael Koutsilieris
The insulin-like growth factors (IGFs) system regulates cell growth, differentiation and energy metabolism and plays crucial role in the regulation of key aspects of tumor biology, such as cancer cell growth, survival, transformation and invasion. The current focus for cancer therapeutic approaches have shifted from the conventional treatments towards the targeted therapies and the IGF system has gained a great interest as anti-cancer therapy. The proliferative, anti-apoptotic and transformation effects of IGFs are mainly triggered by the ligation of the type I IGF receptor (IGF-IR)...
April 2017: Mutation Research
https://www.readbyqxmd.com/read/28528461/novel-imaging-using-a-touchless-display-for-computer-assisted-hepato-biliary-surgery
#18
Yukio Oshiro, Kenoki Ohuchida, Toshiyuki Okada, Makoto Hashizume, Nobuhiro Ohkohchi
PURPOSE: We developed a touchless display system that allows the user to control the medical imaging software via hand gestures in the air. We conducted this study to verify the effectiveness of this novel touchless display system as a tool for assisting with surgical imaging. METHODS: The patient's computed tomography (CT) data are generally observed on a display during surgery. The "Dr. aeroTAP" touchless display system was developed to generate virtual mouse events based on the position of one hand...
May 20, 2017: Surgery Today
https://www.readbyqxmd.com/read/28528120/objective-evaluation-of-corneal-and-lens-clarity-in-children-with-type-1-diabetes-mellitus
#19
Kemal Tekin, Merve Inanc, Erdal Kurnaz, Elvan Bayramoglu, Emre Aydemir, Mustafa Koc, Zehra Aycan
PURPOSE: To investigate whether abnormal glucose metabolism and duration of diabetes mellitus (DM) affected the corneal and lens clarity in children with well-controlled Type 1 DM and to compare the results obtained with those in healthy children. DESIGN: Cross-sectional prospective study. METHODS: This multicenter study enrolled 56 patients with DM and 51 control subjects. The duration of DM and the glycosylated hemoglobin (HbA1c) levels of the patients in the DM group were recorded...
May 17, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28528079/the-lateral-habenula-and-the-serotonergic-system
#20
REVIEW
Martin Metzger, Debora Bueno, Leandro B Lima
The habenula (Hb) is an epithalamic structure differentiated into two nuclear complexes, medial (MHb) and lateral habenula (LHb). After decades of relative neglect, interest in the Hb resurged when it was demonstrated that LHb neurons play a key role in encoding disappointments and expectation of punishments. Consistent with such a role, the LHb has been implicated in a broad array of functions and pathologic conditions, notably in mechanisms of stress and pain, as well as in the pathophysiology of mood disorders...
May 17, 2017: Pharmacology, Biochemistry, and Behavior
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