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Fluoride toxicity

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https://www.readbyqxmd.com/read/27876966/evaluation-of-sodium-fluoride-toxicity-in-schistosoma-infected-snails-assessment-of-antioxidants-antiapoptotic-hypoprotein-and-hypocholesterol-activities
#1
Khaled M M Koriem, Radziyah B Shamsuri, Asliza M Ubaidillah
The snails' tissues represents an intermediate or secondary host for Schistosoma sporocysts where, germ cells within the secondary sporocyst begin to divide to produce thousands of cercariae capable of infecting humans. The aim of the study was to evaluate the toxicity of sodium fluoride in Schistosoma snails' tissue homogenates. A total number of 264 different Schistosoma snails were collected from eight drainage water resources and divided into control uninfected and infected snails; where infected snails divided into four group; the first group without any treatment while second, third and fourth groups immersed in 25, 50 and 100 mg sodium fluoride/L during the period of 4 weeks then the snails' hemolymph and tissue homogenates were prepared to evaluate the snail' tissue antioxidants, protein content, lipid profile and apoptosis...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27871895/protective-effect-of-lycopene-on-fluoride-induced-ameloblasts-apoptosis-and-dental-fluorosis-through-oxidative-stress-mediated-caspase-pathways
#2
Weishan Li, Binghua Jiang, Xianglin Cao, Yongjiang Xie, Ting Huang
Fluoride is an environmental toxicant and induces dental fluorosis and oxidative stress. Lycopene (LYC) is an effective antioxidant that is reported to attenuate fluoride toxicity. To determine the effects of LYC on sodium fluoride (NaF) -induced teeth and ameloblasts toxicity, rats were treated with NaF (10 mg/kg) and/or LYC (10 mg/kg) by orally administration for 5 weeks; ameloblasts were treated with NaF (5 mM) and/or LYC (2 μM) for 6 h. We found that the concentrations of fluoride, malondialdehyde (MDA) and reactive oxygen species (ROS), gene expressions and activities of Caspase-9 and Caspase-3, and the gene expressions of Bax were significantly decreased, while the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPX), the gene expression of Bcl-2 were significantly increased in the LYC + NaF-treated rats group; concentrations of MDA and ROS, gene expressions and activities of Caspase-9 and Caspase-3, and the gene expression of Bax, and ameloblasts apoptosis rate were significantly decreased, while the activities of SOD and GPX, the gene expression of Bcl-2 were significantly increased in the LYC + NaF-treated ameloblasts group...
November 18, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27862939/cell-cycle-arrest-and-gene-expression-profiling-of-testis-in-mice-exposed-to-fluoride
#3
Kai Su, Zilong Sun, Ruiyan Niu, Ying Lei, Jing Cheng, Jundong Wang
Exposure to fluoride results in low reproductive capacity; however, the mechanism underlying the impact of fluoride on male productive system still remains obscure. To assess the potential toxicity in testis of mice administrated with fluoride, global genome microarray and real-time PCR were performed to detect and identify the altered transcriptions. The results revealed that 763 differentially expressed genes were identified, including 330 up-regulated and 433 down-regulated genes, which were involved in spermatogenesis, apoptosis, DNA damage, DNA replication, and cell differentiation...
November 14, 2016: Environmental Toxicology
https://www.readbyqxmd.com/read/27858711/cholinesterase-inhibitor-therapy-in-alzheimer-s-disease-the-limits-and-tolerability-of-irreversible-cns-selective-acetylcholinesterase-inhibition-in-primates
#4
Donald E Moss, Ruth G Perez, Haruo Kobayashi
Irreversible acetylcholinesterase (AChE) inhibition accumulates to high levels in the central nervous system (CNS) because AChE turnover in the brain is much slower than in peripheral tissues. As expected from this CNS selectivity, the irreversible AChE inhibitor methanesulfonyl fluoride (MSF) produces significant cognitive improvement in Alzheimer's disease patients without the gastrointestinal toxicity that plagues other AChE inhibitors. However, without dose-limiting gastrointestinal toxicity, one shortcoming of the prior human studies of MSF is that the upper limits of CNS AChE inhibition that might be tolerated could not be tested...
November 14, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27854046/fluoride-exposure-aggravates-the-testicular-damage-and-sperm-quality-in-diabetic-mice-protective-role-of-ginseng-and-banaba
#5
Saumya Sm, P Mahaboob Basha
Fluoride toxicity is known to pose infertility in fluoride-intoxicated animals as well as in people residing in fluoride endemic zones. The present study addresses the degree of impairments caused due to co-exposure of high fluoride toxicity in diabetic mice. Swiss mice, Mus musculus, were subjected to fluoride toxicity by providing fluoride-supplemented drinking water (600 ppm NaF) for a period of 30 days after the confirmation of streptozotocin-induced diabetes(STZ, 50 mg/kgbw). Consequently, aggravated hyperglycemia and tissue fluoride accumulation were witnessed in fluoride-intoxicated diabetic mice; later, these toxicated mice were treated with ginseng extract (GE) and banaba leaf extract, (BLE) at dose of 150 mg/kgbw/day alone and in combination for 15 and 30-day duration to check the efficacy of phytoextracts in reversing the toxicity...
November 16, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27843247/comparative-evaluation-of-remineralizing-potential-of-three-pediatric-dentifrices
#6
REVIEW
Ashna Kapoor, K R Indushekar, Bhavna G Saraf, Neha Sheoran, Divesh Sardana
INTRODUCTION: Dentifrices are available in different formulations and more commonly a single dentifrice is used by whole family; be it an adult or child. However, concerns over high fluoride in pediatric formulations coupled with inability of the children to spit have led to recommendations to minimize fluoride ingestion during toothbrushing by using a small amount of toothpaste by children and incorporating minimal quantity of fluoride in the toothpastes. Literature is scarce on the remineralization potential of popularly known Indian pediatric dentifrices; hence, pediatric dentifrices containing lesser concentration of fluoride have been marketed relatively recently for the benefit of children without posing a threat of chronic fluoride toxicity at the same time...
July 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27814553/effect-of-fluoride-on-the-cell-viability-cell-organelle-potential-and%C3%A2-photosynthetic-capacity-of-freshwater-and-soil-algae
#7
Yooeun Chae, Dokyung Kim, Youn-Joo An
Although fluoride occurs naturally in the environment, excessive amounts of fluoride in freshwater and terrestrial ecosystems can be harmful. We evaluated the toxicity of fluoride compounds on the growth, viability, and photosynthetic capacity of freshwater (Chlamydomonas reinhardtii and Pseudokirchneriella subcapitata) and terrestrial (Chlorococcum infusionum) algae. To measure algal growth inhibition, a flow cytometric method was adopted (i.e., cell size, granularity, and auto-fluorescence measurements), and algal yield was calculated to assess cell viability...
October 28, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27810507/effect-of-fe-ii-ce-iii-dosage-ratio-on-the-structure-and-anion-adsorptive-removal-of-hydrothermally-precipitated-composites-insights-from-exafs-xanes-xrd-and-ftir
#8
Natalia Chubar, Vasyl Gerda, Dipanjan Banerjee, Ganna Yablokova
In this work, we present material chemistry in the hydrothermal synthesis of new complex structure materials based on various dosage ratios of Fe and Ce (1:0, 2:1, 1:1, 1:2, 0:1), characterize them by the relevant methods that allow characterization of both crystalline and amorphous phases and correlate their structure/surface properties with the adsorptive performance of the five toxic anions. The applied synthesis conditions resulted in the formation of different compounds of Fe and Ce components. The Fe-component was dominated by various phases of Fe hydrous oxides, whereas the Ce-component was composed of various phases of Ce carbonates...
October 24, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27787813/the-influence-of-fluorine-on-the-disturbances-of-homeostasis-in-the-central-nervous-system
#9
REVIEW
K Dec, A Łukomska, D Maciejewska, K Jakubczyk, I Baranowska-Bosiacka, D Chlubek, A Wąsik, I Gutowska
Fluorides occur naturally in the environment, the daily exposure of human organism to fluorine mainly depends on the intake of this element with drinking water and it is connected with the geographical region. In some countries, we can observe the endemic fluorosis-the damage of hard and soft tissues caused by the excessive intake of fluorine. Recent studies showed that fluorine is toxic to the central nervous system (CNS). There are several known mechanisms which lead to structural brain damage caused by the excessive intake of fluorine...
October 27, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27766093/isolation-and-characterization-of-gut-bacterial-proteases-involved-in-inducing-pathogenicity-of-bacillus-thuringiensis-toxin-in-cotton-bollworm-helicoverpa-armigera
#10
Visweshwar Regode, Sreeramulu Kuruba, Akbar S Mohammad, Hari C Sharma
Bacillus thuringiensis toxin proteins are deployed in transgenic plants for pest management. The present studies were aimed at characterization of gut bacterial proteases involved in activation of inactive Cry1Ac protoxin (pro-Cry1Ac) to active toxin in Helicoverpa armigera. Bacterial strains were isolated from H. armigera midgut and screened for their proteolytic activation toward pro-Cry1Ac. Among 12 gut bacterial isolates seven isolates showed proteolytic activity, and proteases from three isolates (IVS1, IVS2, and IVS3) were found to be involved in the proteolytic conversion of pro-Cry1Ac into active toxin...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27754647/ammonium-fluoride-mediated-synthesis-of-anhydrous-metal-fluoride-mesoporous-carbon-nanocomposites-for-high-performance-lithium-ion-battery-cathodes
#11
Jinyoung Chun, Changshin Jo, Sunhye Sahgong, Min Gyu Kim, Eunho Lim, Dong Hyeon Kim, Jongkook Hwang, Eunae Kang, Keun Ah Ryu, Yoon Seok Jung, Youngsik Kim, Jinwoo Lee
Metal fluorides (MFx) are one of the most attractive cathode candidates for Li-ion batteries (LIBs) due to their high conversion potentials with large capacities. However, only a limited number of synthetic method, generally involving highly toxic or inaccessible reagents, currently exist, which has made it difficult to produce well-designed nanostructures suitable for cathodes; consequently, harnessing their potential cathodic properties has been a challenge. Herein, we report a new bottom-up synthetic method utilizing ammonium fluoride (NH4F) for the preparation of anhydrous MFx(CuF2, FeF3, and CoF2)/mesoporous carbon(MSU-F-C) nanocomposites, whereby a series of metal precursor nanoparticles pre-confined in mesoporous carbon were readily converted to anhydrous MFx through simple heat treatment with NH4F under solventless conditions...
October 18, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27750169/arsenic-and-fluoride-induce-apoptosis-inflammation-and-oxidative-stress-in-cultured-human-umbilical-vein-endothelial-cells
#12
Yanqin Ma, Zhenhua Ma, Shuqin Yin, Xiaoyan Yan, Jundong Wang
Excessive amount of inorganic arsenic (iAs) and fluoride (F) coexist in drinking water in many regions, which is associated with high risk of vascular diseases. However, the underlying mechanisms are not well studied. The present study was to evaluate the effects of iAs and F individual or combined exposure on endothelial activation and apoptosis in vitro. Primary human umbilical vein endothelial cells (HUVECs) were exposed to 5 μM As2O3 and/or 1 mM NaF. Changes in endothelial cell apoptosis, inflammation, oxidative stress and nitric oxide (NO) production were analyzed...
October 14, 2016: Chemosphere
https://www.readbyqxmd.com/read/27700992/toxicity-assessment-of-sodium-fluoride-in-drosophila-melanogaster-after-chronic-sub-lethal-exposure
#13
Moumita Dutta, Prem Rajak, Salma Khatun, Sumedha Roy
Sodium fluoride (NaF), one of the most frequently used fluoride compound is composed of Na(+) and F(-). Apart from its use in water fluoridation, NaF also acts as a major component for different dental products like toothpastes, gels and mouth rinses etc. The present study was carried out to explore the toxic impact of chronic NaF exposure on a non-target organism, Drosophila melanogaster. The larvae exposed to different concentrations of NaF through food showed a significant increase in HSP70 expression both qualitatively and quantitatively...
January 2017: Chemosphere
https://www.readbyqxmd.com/read/27690006/itraq-based-proteomics-analysis-of-serum-proteins-in-wistar-rats-treated-with-sodium-fluoride-insight-into-the-potential-mechanism-and-candidate-biomarkers-of-fluorosis
#14
Yan Wei, Beibei Zeng, Hua Zhang, Cheng Chen, Yanli Wu, Nanlan Wang, Yanqiu Wu, Liming Shen
Fluorosis induced by exposure to high level fluoride is quite widespread in the world. The manifestations of fluorosis include dental mottling, bone damage, and impaired malfunction of soft tissues. However, the molecular mechanism of fluorosis has not been clarified until now. To explore the underlying mechanisms of fluorosis and screen out serum biomarkers, we carried out a quantitative proteomics study to identify differentially expressed serum proteins in Wistar rats treated with sodium fluoride (NaF) by using a proteomics approach of isobaric tagging for relative and absolute quantitation (iTRAQ)...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27687764/role-of-spirulina-in-mitigating-hemato-toxicity-in-swiss-albino-mice-exposed-to-aluminum-and-aluminum-fluoride
#15
Shweta Sharma, K P Sharma, Subhasini Sharma
Aluminum is ingested through foods, water, air, and even drugs. Its intake is potentiated further through foods and tea prepared in aluminum utensils and Al salt added in the drinking water for removal of suspended impurities and also fluoride in the affected areas. The ameliorating role of a blue green alga Spirulina is well documented to various pollutants in the animal models. We, therefore, examined its protective role (230 mg/kg body weight) on the hematology of male Swiss albino mice treated with aluminum (sub-acute = 78...
September 29, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27681108/the-effect-of-the-number-of-alkyl-substituents-on-imidazolium-ionic-liquids-phytotoxicity-and-oxidative-stress-in-spring-barley-and-common-radish-seedlings
#16
Robert Biczak, Barbara Pawłowska, Arkadiusz Telesiński, Wojciech Ciesielski
Increasing amounts of two ILs: 1-butyl-3-methylimidazolium hexafluorophosphate [BMIM][PF6] and 1-butyl-2,3-dimethylimidazolium hexafluorophosphate [BMMIM][PF6], were introduced to soil in which spring barley (Hordeum vulgare) and common radish (Raphanus sativus L. subvar. radicula Pers.) seedlings were cultivated, in order to evaluate the phytotoxicity of ionic liquids with imidazolium cation with two or three alkyl substituents attached. The results of the study i.e. the inhibition of the length of plants and their roots, as well as the yield of fresh weight of plants, clearly showed that differences in the number of substituents did not affect the toxicity of these ILs...
December 2016: Chemosphere
https://www.readbyqxmd.com/read/27664006/choline-supplementation-alleviates-fluoride-induced-testicular-toxicity-by-restoring-the-ngf-and-mek-expression-in-mice
#17
Jianhai Zhang, Yufang Zhang, Chen Liang, Nasui Wang, Heping Zheng, Jundong Wang
Fluoride is known to cause male reproductive toxicity, and the elucidation of its underlying mechanisms is an ongoing research focus in reproductive toxicology and epidemiology. Choline, an essential nutrient, has been extensively studied for its benefits in nervous system yet was rarely discussed for its prospective effect in male reproductive system. This study aims to explore the potential protective role of choline against NaF-induced male reproductive toxicity via MAPK pathway. The male mice were administrated by 150mg/L NaF in drinking water, 5...
November 1, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27661093/tailoring-water-resistant-and-breathable-performance-of-polyacrylonitrile-nanofibrous-membranes-modified-by-polydimethylsiloxane
#18
Junlu Sheng, Min Zhang, Yue Xu, Jianyong Yu, Bin Ding
The demand of water-resistant and breathable materials applied to a separation medium and protective garments is steadily increasing. Typical approaches to obtain these functional materials are based on hydrophobic agents and porous substrates with small fiber diameter, tiny pore, and high porosity. However, a fluorinated hydrophobic finishing agent usually employed in providing effective waterproofness is limited with respect to their environmental persistence and toxic potential. Herein, with the aim to keep a balance between the water-resistance and breathability as well as mechanical properties, we fabricate a novel fluoride-free functional membrane by electrospun polyacrylonitrile (PAN) nanofibers modified with polydimethylsiloxane (PDMS)...
October 12, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27645723/collecting-quality-infrared-spectra-from-microscopic-samples-of-suspicious-powders-in-a-sealed-cell
#19
Brooke W Kammrath, Pauline E Leary, John A Reffner
The infrared (IR) microspectroscopical analysis of samples within a sealed-cell containing barium fluoride is a critical need when identifying toxic agents or suspicious powders of unidentified composition. The dispersive nature of barium fluoride is well understood and experimental conditions can be easily adjusted during reflection-absorption measurements to account for differences in focus between the visible and IR regions of the spectrum. In most instances, the ability to collect a viable spectrum is possible when using the sealed cell regardless of whether visible or IR focus is optimized...
September 19, 2016: Applied Spectroscopy
https://www.readbyqxmd.com/read/27642129/antimicrobial-and-cytotoxicity-evaluation-of-colloidal-chitosan-silver-nanoparticles-fluoride-nanocomposites
#20
Priscila L L Freire, Allan J R Albuquerque, Isabela A P Farias, Teresinha Gonçalves da Silva, Jaciana Santos Aguiar, André Galembeck, Miguel A P Flores, Fabio C Sampaio, Thayza Christina Montenegro Stamford, Aronita Rosenblatt
The present study aimed to evaluate the antimicrobial activity and cytotoxicity of colloidal chitosan - silver nanoparticle - fluoride nanocomposites (CChAgNpFNc), with different silver nanoparticle shapes and sizes. The syntheses of CChAgNpFNc were performed with silver nitrate added to a chitosan solution, addition of a sodium borohydride solution and solid sodium fluoride. Solution of ascorbic acid was added to synthesize larger silver nanoparticles. CChAgNpFNc obtained: S1- 100% spherical, 8.7±3.1nm; S2- 97% spherical, 15...
September 15, 2016: International Journal of Biological Macromolecules
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