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Fluoride toxicity

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https://www.readbyqxmd.com/read/28719589/an-excited-state-underlies-gene-regulation-of-a-transcriptional-riboswitch
#1
Bo Zhao, Sharon L Guffy, Benfeard Williams, Qi Zhang
Riboswitches control gene expression through ligand-dependent structural rearrangements of the sensing aptamer domain. However, we found that the Bacillus cereus fluoride riboswitch aptamer adopts identical tertiary structures in solution with and without ligand. Using chemical-exchange saturation transfer (CEST) NMR spectroscopy, we revealed that the structured ligand-free aptamer transiently accesses a low-populated (∼1%) and short-lived (∼3 ms) excited conformational state that unravels a conserved 'linchpin' base pair to signal transcription termination...
July 17, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28687488/rescuing-fluoride-induced-damages-in-liver-with-gamma-aminobutyric-acid
#2
Haoyue Yang, Ronge Xing, Song Liu, Huahua Yu, Pengcheng Li
Fluorine poisoning affects human health all over the world and an urgent task is to develop alleviative medicine to recover or ameliorate the damages to the body. Here we studied the effects of gamma-aminobutyric acid (GABA), a liver protector reported previously, on fluoride-induced damage in the mouse liver. Through microscope imaging of the liver tissue, TUNEL immunostaining, real-time RT-PCR, enzyme immunoassay and colorimetric method, we found that GABA supplementation prevented the metabolic toxicity caused by fluoride treatment in mice...
July 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28674607/fluoroacetate-in-plants-a-review-of-its-distribution-toxicity-to-livestock-and-microbial-detoxification
#3
REVIEW
Lex Ee Xiang Leong, Shahjalal Khan, Carl K Davis, Stuart E Denman, Chris S McSweeney
Fluoroacetate producing plants grow worldwide and it is believed they produce this toxic compound as a defence mechanism against grazing by herbivores. Ingestion by livestock often results in fatal poisonings, which causes significant economic problems to commercial farmers in many countries such as Australia, Brazil and South Africa. Several approaches have been adopted to protect livestock from the toxicity with limited success including fencing, toxic plant eradication and agents that bind the toxin. Genetically modified bacteria capable of degrading fluoroacetate have been able to protect ruminants from fluoroacetate toxicity under experimental conditions but concerns over the release of these microbes into the environment have prevented the application of this technology...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28672688/fluoride-exposure-changed-the-structure-and-the-expressions-of-hsp-related-genes-in-testes-of-pubertal-rats
#4
Yangfei Zhao, Jun Zhao, Jinming Wang, Jundong Wang
Previous studies have indicated that fluoride exposure damaged the male reproductive function; however, the cellular mechanism of fluoride-induced testicular toxicity is still unclear. In this study, twenty-two female pregnant Wistar rats were allotted randomly to two groups: control (deionized water) and sodium fluoride (NaF, contain F(-): 67.86 mg/L) groups. After delivery, the dosage was continued for 15 weeks for puppies. Twelve rats in each group were tested at 6 and 9 (pubertal); 12 and 15 (mature) weeks of age...
June 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28654759/taurine-reverses-sodium-fluoride-mediated-increase-in-inflammation-caspase-3-activity-and-oxidative-damage-along-the-brain-pituitary-gonadal-axis-in-male-rats
#5
Isaac A Adedara, Bolanle F Olabiyi, TeminiJesu D Ojuade, Umar F Idris, Esther M Onibiyo, Ebenezer O Farombi
Excessive exposure to fluoride is associated with male reproductive dysfunction in humans and animals. Taurine (2-aminoethane sulfonic acid) is a free intracellular β-amino acid with antioxidant, anti-inflammatory, and neuroprotective properties. However, the effect of taurine on fluoride-induced reproductive toxicity has not been reported. The present study investigated the influence of taurine on sodium fluoride (NaF)-induced functional changes along the brain-pituitary-gonadal axis in male rats. NaF was administered singly in drinking water at 15 mg·L(-1) alone or orally co-administered by gavage with taurine at 100 and 200 mg·(kg body mass)(-1) for 45 consecutive days...
June 27, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28648730/removal-of-cu-ii-ions-from-contaminated-waters-using-a-conducting-microfiltration-membrane
#6
Xueye Wang, Zhiwei Wang, Haiqin Chen, Zhichao Wu
Efficient removal of toxic metals using low-pressure membrane processes from contaminated waters is an important but challenging task. In the present work, a conducting microfiltration membrane prepared by embedding a stainless steel mesh in the active layer of a polyvinylidene fluoride membrane is developed to remove Cu(II) ions from contaminated waters. Results showed that the conducting membrane had favorable electrochemical properties and stability as cathode. Batch tests showed that Cu(II) removal efficiency increased with the increase of voltages and leveled off with the further enhancement of electric field...
June 19, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28643283/role-of-cation-structure-in-the-phytotoxicity-of-ionic-liquids-growth-inhibition-and-oxidative-stress-in-spring-barley-and-common-radish
#7
Robert Biczak, Barbara Pawłowska, Arkadiusz Telesiński, Janusz Kapuśniak
The present study determines the influence of three ionic liquids (ILs) containing cations with diversified structure on the growth and development of spring barley seedlings and common radish leaves. Increasing amounts of 1-butyl-1-methylpyrrolidinium hexafluorophosphate [Pyrrol][PF6], 1-butyl-1-methylpiperidinium hexafluorophosphate [Piper][PF6], and 1-butyl-4-methylpyridinium hexafluorophosphate [Pyrid][PF6] were added to the soil on which both plants were cultivated. The results of this studies showed that the applied ILs were highly toxic for plants, demonstrated by the inhibition of length of plant shoots and roots, decrease of fresh mass, and increase of dry weight content...
June 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28638415/corrigendum-to-physiologic-conditions-affect-toxicity-of-ingested-industrial-fluoride
#8
Richard Sauerheber
[This corrects the article DOI: 10.1155/2013/439490.].
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28636233/green-synthesis-of-small-nanoparticles-of-a2sif6-a-li-cs-using-ionic-liquids-as-solvent-and-fluorine-source-a-novel-simple-approach-without-hf
#9
Jacob Olchowka, Markus Suta, Claudia Wickleder
In this communication, nanoparticles of the fluoridosilicates A2SiF6 (A= Li, Na, K, Rb, Cs), which are extremely promising host lattices for future LEDs, are presented for the first time. The preparation method we introduces here is a very simple and energy and time saving one, moreover the usage of toxic HF or elemental fluorine is avoided. In detail, the ionic liquid [Bmim]PF6 was used both as solvent and fluoride source in an ionothermally assisted microwave synthesis. The small size of the so obtained nanoparticles is of huge relevance for their applications as thin films or coverage of surfaces for, e...
June 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28626624/biocompatibility-and-in-vivo-operation-of-implantable-mesoporous-pvdf-based-nanogenerators
#10
Yanhao Yu, Haiyan Sun, Hakan Orbay, Feng Chen, Christopher G England, Weibo Cai, Xudong Wang
The rapid developments of implantable biomedical electronics give rise to the motivation of exploring efficient and durable self-powered charging system. In this paper, we report a mesoporous polyvinylidene fluoride (PVDF)-based implantable piezoelectric nanogenerator (NG) for in vivo biomechanical energy harvesting. The NG was built with a sponge-like mesoporous PVDF film and encapsulated by polydimethylsiloxane (PDMS). After embedding this NG into rodents, a Voc of ~200 mV was produced from the gentle movement of rodent muscle...
September 2016: Nano Energy
https://www.readbyqxmd.com/read/28622605/flexible-nanofilms-coated-with-aligned-piezoelectric-microfibers-preserve-the-contractility-of-cardiomyocytes
#11
P José Gouveia, S Rosa, L Ricotti, B Abecasis, H V Almeida, L Monteiro, J Nunes, F Sofia Carvalho, M Serra, S Luchkin, A Leonidovitch Kholkin, P Marques Alves, P Jorge Oliveira, R Carvalho, A Menciassi, R Pires das Neves, L Silva Ferreira
The use of engineered cardiac tissue for high-throughput drug screening/toxicology assessment remains largely unexplored. Here we propose a scaffold that mimics aspects of cardiac extracellular matrix while preserving the contractility of cardiomyocytes. The scaffold is based on a poly(caprolactone) (PCL) nanofilm with magnetic properties (MNF, standing for magnetic nanofilm) coated with a layer of piezoelectric (PIEZO) microfibers of poly(vinylidene fluoride-trifluoroethylene) (MNF+PIEZO). The nanofilm creates a flexible support for cell contraction and the aligned PIEZO microfibers deposited on top of the nanofilm creates conditions for cell alignment and electrical stimulation of the seeded cells...
September 2017: Biomaterials
https://www.readbyqxmd.com/read/28604070/effect-of-fluoride-on-photosynthetic-pigment-content-and-antioxidant-system-of-hydrilla-verticillata
#12
Jingqing Gao, Chun Liu, Jingshen Zhang, Songfeng Zhu, Yu Shen, Ruiqin Zhang
Fluoride can either inhibit or enhance the growth of aquatic macrophytes, depending upon fluoride concentration and exposure time. To investigate fluoride toxicity, the submerged plant Hydrilla verticillata was treated with various concentrations of fluoride (F) (0, 10, 20 and 40 mg/L) for different lengths of time (7, 14, 21 and 28 days). At exposure to 10 mg/L F, the content of chlorophyll, protein and carbohydrates content increased in leaves of H. verticillata and the activity of guaiacol peroxidase (POD) and superoxide dismutase (SOD) slightly increased in plants compared with the control...
June 12, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28603418/vesicular-melatonin-efficiently-downregulates-sodium-fluoride-induced-rat-hepato-and-broncho-tnf-%C3%AE-tgf-%C3%AE-expressions-and-associated-oxidative-injury-a-comparative-study-of-liposomal-and-nanoencapsulated-forms
#13
Suvomoy Sana, Swarupa Ghosh, Nirmalendu Das, Sibani Sarkar, Ardhendu Kumar Mandal
The importance of fluoride as a natural and industrial toxicant is recognized worldwide. We evaluated the regulating role and biological effect of vesicular (liposomal and nanoencapsulated) melatonin (N-acetyl-5-methoxytryptamine) for drug delivery and controlled release on the depletion of inflammatory mediators, as well as oxidative damage in sodium fluoride (NaF)-treated lungs and liver. Hepatic and bronchial damage was induced in Swiss albino rats with a single acute ingestion of NaF (48 mg/kg body weight, oral gavage)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28579140/alteration-of-paraoxonase-arylesterase-and-lactonase-activities-in-people-around-fluoride-endemic-area-of-tamil-nadu-india
#14
Mani Arulkumar, Raji Vijayan, Sakayanathan Penislusshiyan, Palanivel Sathishkumar, Jayaraman Angayarkanni, Thayumanavan Palvannan
BACKGROUND: Toxicity due to excess fluoride concentration in drinking water is of great concern in people who rely only on the ground water as their water source in many region of the world. METHODS: We collected samples and examined the toxicity of fluoride in a population residing at Salem, Dharmapuri and Krishnagiri districts of Tamil Nadu, India and measured HDL bound enzyme (PON1), erythrocyte membrane bound enzymes (acetylcholinesterase, AChE) and adenosine 5' triphosphatase (ATPases), plasma enzyme (butyrylcholinesterase, BChE) and rate limiting enzyme in heme biosynthesis (delta aminolevulinic acid dehydratase, δ-ALAD) activities...
June 1, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28553235/4-phenylbutyrate-mitigates-fluoride-induced-cytotoxicity-in-alc-cells
#15
Maiko Suzuki, Eric T Everett, Gary M Whitford, John D Bartlett
Chronic fluoride over-exposure during pre-eruptive enamel development can cause dental fluorosis. Severe dental fluorosis is characterized by porous, soft enamel that is vulnerable to erosion and decay. The prevalence of dental fluorosis among the population in the USA, India and China is increasing. Other than avoiding excessive intake, treatments to prevent dental fluorosis remain unknown. We previously reported that high-dose fluoride induces endoplasmic reticulum (ER) stress and oxidative stress in ameloblasts...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28537079/green-water-dispersible-photoluminescent-on-off-on-probe-for-selective-detection-of-fluoride-ions
#16
Pallavi Singhal, Bal Govind Vats, Sanjay K Jha, Suman Neogy
Considering the high toxicity and widespread availability of fluoride ions in different environmental matrices, it is imperative to design a probe for its detection. In view of this, a selective fluorescent on-off-on probe based on carbon quantum dots (CQDs) and Eu(3+) has been designed. We have synthesized water-soluble carboxylic acid-functionalized CQDs and monitored their interaction with Eu(3+). Luminescence quenching in the CQD emission was observed (switch-off) on adding Eu(3+) ions. We investigate the reason for this luminescence quenching using time-resolved emission and high-resolution transmission electron microscopy (HRTEM) studies and observed that both electron transfer from CQDs to Eu(3+) and aggregation of CQDs are responsible for the luminescence quenching...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28535068/conformal-lithium-fluoride-protection-layer-on-three-dimensional-lithium-by-nonhazardous-gaseous-reagent-freon
#17
Dingchang Lin, Yayuan Liu, Wei Chen, Guangmin Zhou, Kai Liu, Bruce Dunn, Yi Cui
Research on lithium (Li) metal chemistry has been rapidly gaining momentum nowadays not only because of the appealing high theoretical capacity, but also its indispensable role in the next-generation Li-S and Li-air batteries. However, two root problems of Li metal, namely high reactivity and infinite relative volume change during cycling, bring about numerous other challenges that impede its practical applications. In the past, extensive studies have targeted these two root causes by either improving interfacial stability or constructing a stable host...
June 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/28523621/ecotoxicological-assessment-of-the-impact-of-fluoride-f-and-turbidity-on-the-freshwater-snail-physella-acuta-in-a-polluted-river-receiving-an-industrial-effluent
#18
Julio A Camargo, Álvaro Alonso
We carried out field studies and laboratory experiments to assess the impact of fluoride (F(-)) and turbidity on the freshwater snail Physella acuta in a polluted river receiving an industrial effluent (the middle Duraton River, Central Spain). Fluoride concentrations and turbidity levels significantly increased downstream from the industrial effluent (with the highest values being 0.6 mg F(-)/L and 55.2 nephelometric turbidity unit). In addition, higher deposition of fine inorganic matter was evident at polluted sampling sites...
May 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28494360/fluoride-induces-apoptosis-in-h9c2-cardiomyocytes-via-the-mitochondrial-pathway
#19
Xiaoyan Yan, Lu Wang, Xia Yang, Yulan Qiu, Xiaolin Tian, Yi Lv, Fengjie Tian, Guohua Song, Tong Wang
Numerous studies have shown that chronic excessive fluoride intake can adversely affect different organ systems. In particular, the cardiovascular system is susceptible to disruption by a high concentration of fluoride. The objectives of this study were to explore the mechanism of apoptosis by detecting the toxic effects of different concentrations of sodium fluoride (NaF) in H9c2 cells exposed for up to 96 h. NaF not only inhibited H9c2 cell proliferation but also induced apoptosis and morphological damage...
May 1, 2017: Chemosphere
https://www.readbyqxmd.com/read/28478709/elimination-of-ethanethiol-released-from-municipal-wastes-by-absorption-sequencing-electrochemical-oxidation
#20
Xiao Gong, Xu Yang, Haoyue Zheng, Zucheng Wu
As a typical municipal waste landfill gas, ethanethiol can become an air pollutant because of its low odor threshold concentration and toxicity to human beings. A hybrid process of absorption combined with electrochemical oxidation to degrade ethanethiol was investigated. The ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM]BF4) was employed as an absorbent to capture ethanethiol from the air stream. Electrochemical oxidation demonstrated that ethanethiol could be oxidized on a β-PbO2 anode modified with fluoride, while [BMIM]BF4 was used as an electrolyte...
May 7, 2017: Environmental Technology
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