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Fluoride toxicity

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https://www.readbyqxmd.com/read/28523621/ecotoxicological-assessment-of-the-impact-of-fluoride-f-and-turbidity-on-the-freshwater-snail-physella-acuta-in-a-polluted-river-receiving-an-industrial-effluent
#1
Julio A Camargo, Álvaro Alonso
We carried out field studies and laboratory experiments to assess the impact of fluoride (F(-)) and turbidity on the freshwater snail Physella acuta in a polluted river receiving an industrial effluent (the middle Duraton River, Central Spain). Fluoride concentrations and turbidity levels significantly increased downstream from the industrial effluent (with the highest values being 0.6 mg F(-)/L and 55.2 nephelometric turbidity unit). In addition, higher deposition of fine inorganic matter was evident at polluted sampling sites...
May 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28494360/fluoride-induces-apoptosis-in-h9c2-cardiomyocytes-via-the-mitochondrial-pathway
#2
Xiaoyan Yan, Lu Wang, Xia Yang, Yulan Qiu, Xiaolin Tian, Yi Lv, Fengjie Tian, Guohua Song, Tong Wang
Numerous studies have shown that chronic excessive fluoride intake can adversely affect different organ systems. In particular, the cardiovascular system is susceptible to disruption by a high concentration of fluoride. The objectives of this study were to explore the mechanism of apoptosis by detecting the toxic effects of different concentrations of sodium fluoride (NaF) in H9c2 cells exposed for up to 96 h. NaF not only inhibited H9c2 cell proliferation but also induced apoptosis and morphological damage...
May 1, 2017: Chemosphere
https://www.readbyqxmd.com/read/28478709/elimination-of-ethanethiol-released-from-municipal-wastes-by-absorption-sequencing-electrochemical-oxidation
#3
Xiao Gong, Xu Yang, Haoyue Zheng, Zucheng Wu
As a typical municipal waste landfill gas, ethanethiol can become an air pollutant because of its low odor threshold concentration and toxicity to human beings. A hybrid process of absorption combined with electrochemical oxidation to degrade ethanethiol was investigated. The ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM]BF4) was employed as an absorbent to capture ethanethiol from the air stream. Electrochemical oxidation demonstrated that ethanethiol could be oxidized on a β-PbO2 anode modified with fluoride, while [BMIM]BF4 was used as an electrolyte...
May 7, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28472134/fluoride-export-fex-proteins-from-fungi-plants-and-animals-are-single-barreled-channels-containing-one-functional-and-one-vestigial-ion-pore
#4
Tetyana Berbasova, Sunitha Nallur, Taylor Sells, Kathryn D Smith, Patricia B Gordon, Susan Lori Tausta, Scott A Strobel
The fluoride export protein (FEX) in yeast and other fungi provides tolerance to fluoride (F-), an environmentally ubiquitous anion. FEX efficiently eliminates intracellular fluoride that otherwise would accumulate at toxic concentrations. The FEX homolog in bacteria, Fluc, is a 'double-barreled' channel formed by dimerization of two identical or similar subunits. FEX in yeast and other eukaryotes is a monomer resulting from covalent fusion of the two subunits. As a result, both potential fluoride pores are created from different parts of the same protein...
2017: PloS One
https://www.readbyqxmd.com/read/28463508/aggregation-and-dissociation-of-aqueous-al13-induced-by-fluoride-substitution
#5
Xiao Wang, Gong Zhang, Xiaoning Fu, Chengzhi Hu, Ruiping Liu, Huijuan Liu, Xiufang Xu, Jiuhui Qu
The ε-Keggin ion AlO4Al12(OH)24(H2O)12(7+) (ε-K Al13(7+)) is a double-edged sword, because it commonly acts as a toxic component toward aquatic organisms, but also is considered to be an effective coagulant. Gaining deep insight into the transformation of ε-K Al13(7+) in the presence of coexisting ligands would have significant implications for water environmental science, as well as for practical water purification. The aggregation and dissociation of aqueous Al13(7+) induced by fluoride (F(-)) substitution were herein investigated using nuclear magnetic resonance, electrospray ionization-mass spectrometry, and theoretical calculations...
May 10, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28462439/ameliorative-effect-of-ve-igf-i-and-hcg-on-the-fluoride-induced-testosterone-release-suppression-in-mice-leydig-cells
#6
Yuxiang Yu, Yongli Han, Ruiyan Niu, Jundong Wang, Ram Kumar Manthari, Mohammad Mehdi Ommati, Zilong Sun
Excessive consumption of fluoride (F) through drinking, eating, and/or environmental contaminants induces chronic toxicity known as fluorosis. Our previous research has shown that fluorosis was associated with male reproductive disorders. The current study is designed to explain the protective effect of vitamin E (VE), insulin-like growth factor-I (IGF-I), and human chorionic gonadotropin (hCG) against natrium fluoride (NaF)-induced alterations in isolated Leydig cells (LCs). These NaF-induced alterations include decreased cell proliferation, steroidogenesis, and relative gene expression...
May 1, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28455443/metalloriboswitches-rna-based-inorganic-ion-sensors-that-regulate-genes
#7
Joseph E Wedekind, Debapratim Dutta, Ivan A Belashov, Jermaine L Jenkins
Divalent ions fulfill essential cellular roles and are required for virulence by certain bacteria. Free intracellular Mg(2+) can approach 5 mM, but at this level, Mn(2+), Ni(2+), or Co(2+) can be growth-inhibitory, and Mg(2+)-fluoride is toxic. To maintain ion homeostasis, many bacteria have evolved ion sensors embedded in the 5'-leader sequences of mRNAs encoding ion uptake or efflux channels. Here, we review current insights into these "metalloriboswitches," emphasizing ion-specific binding by structured RNA aptamers and associated conformational changes in downstream signal sequences...
April 28, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28452774/electrochemical-oxidation-of-quinoline-aqueous-solution-on-%C3%AE-pbo2-anode-and-the-evolution-of-phytotoxicity-on-duckweed
#8
Xiangjuan Ma, Lixia Bian, Jingfeng Ding, Yaping Wu, Huilong Xia, Jionghui Li
Electrochemical oxidation of quinoline on a β-PbO2 electrode modified with fluoride resin and the comprehensive toxicity of intermediates formed during oxidation on duckweed were investigated in detail. The results showed that quinoline was initially hydroxylated at the C-2 and C-8 positions by hydroxyl radicals (·OH) electro-generated on a β-PbO2 anode, yielding 2(1H)-quinolinone and 8-hydroxyquinoline, then undergoing ring cleavage to form pyridine, nicotinic acid, pyridine-2-carboxaldehyde and acetophenone, which were ultimately converted to biodegradable organic acids...
April 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28451878/differential-expression-of-myocardial-heat-shock-proteins-in-rats-acutely-exposed-to-fluoride
#9
Lakshmikanthan Panneerselvam, Azhwar Raghunath, Ekambaram Perumal
Acute fluoride (F(-)) toxicity is known to cause severe cardiac complications and leads to sudden heart failure. Previously, we reported that increased myocardial oxidative damage, apoptosis, altered cytoskeleton and AMPK signaling proteins associated with energy deprivation in acute F(-) induced cardiac dysfunction. The present study was aimed to decipher the status of myocardial heat shock proteins (Hsps-Hsp27, Hsp32, Hsp40, Hsp60, Hsp70, Hsp90) and heat shock transcription factor 1 (Hsf1) in acute F(-)-intoxicated rats...
April 27, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28447695/phase-transformation-of-tio2-nanoparticles-by-femtosecond-laser-ablation-in-aqueous-solutions-and-deposition-on-conductive-substrates
#10
Paola Russo, Robert Liang, Rui Xiu He, Y Norman Zhou
Titanium dioxide (TiO2) is a wide bandgap semiconductor that is chemically stable, non-toxic, and economical compared to other semiconductors and has been implemented in a wide range of applications such as photocatalysis, photovoltaics, and memristors. In this work we studied the femtosecond laser ablation of titanium dioxide powders (P25) dispersed either in water or deposited onto a fluoride-doped tin oxide (FTO) substrate. The process was used as a route to induce the phase-transformation of TiO2 nanoparticles which was governed by laser parameters such as ablation time and power...
May 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28405851/fluoride-induces-neuroinflammation-and-alters-wnt-signaling-pathway-in-bv2-microglial-cells
#11
Rui Chen, Lian-Dong Zhao, Hong Liu, Hui-Hua Li, Chao Ren, Peng Zhang, Ke-Tai Guo, Hong-Xi Zhang, De-Qin Geng, Cai-Yi Zhang
Fluoride is a common element in nature and our daily life, and excessive intake of this element can cause fluorosis and irreversible brain damage. The toxic effects of fluoride on the central nervous system may be attributed to the release of inflammatory cytokines and ROS. GSK3β is a key protein that modulates NF-κB activity and inflammatory cytokine levels and plays an important role in the Wnt signaling pathway. In this study, we found that fluoride altered the inflammatory status and oxidative stress by inhibiting Wnt signaling pathway activity...
April 12, 2017: Inflammation
https://www.readbyqxmd.com/read/28402899/detection-of-cyanide-ions-in-aqueous-solutions-using-cost-effective-colorimetric-sensor
#12
P Madhusudhana Reddy, Shih-Rong Hsieh, Chi-Jung Chang, Jing-Yuan Kang
Cyanide (CN̄) is one of the most toxic material to the human and environment. It is very important to develop the diagnostic tools for the detection of CN̄ ions. Moreover, detection of the ions in an aqueous medium is a challenging task as water molecules interfere with the sensing mechanism. In this context, we prepared chemical sensor, S1, having anthraquinone as a signaling unit and thiourea as a binding site. This sensor exhibited distinct visual color and spectral changes in response to CN̄ ion over other testing anions in 50% aq...
April 3, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28395203/reliability-of-plant-root-comet-assay-in-comparison-with-human-leukocyte-comet-assay-for-assessment-environmental-genotoxic-agents
#13
Gabriela Barreto Dos Reis, Larissa Fonseca Andrade-Vieira, Isabella de Campos Moraes, Pedro Henrique Souza César, Silvana Marcussi, Lisete Chamma Davide
Comet assay is an efficient test to detect genotoxic compounds based on observation of DNA damage. The aim of this work was to compare the results obtained from the comet assay in two different type of cells extracted from the root tips from Lactuca sativa L. and human blood. For this, Spent Pot Liner (SPL), and its components (aluminum and fluoride) were applied as toxic agents. SPL is a solid waste generated in industry from the aluminum mining and processing with known toxicity. Three concentrations of all tested solutions were applied and the damages observed were compared to negative and positive controls...
August 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28390313/accumulation-and-interaction-of-fluoride-and-cadmium-in-the-soil-wheat-plant-system-from-the-wastewater-irrigated-soil-of-an-oasis-region-in-northwest-china
#14
Yepu Li, Shengli Wang, Daniel Prete, Suyin Xue, Zhongren Nan, Fei Zang, Qian Zhang
Contamination of agricultural soil with high concentrations of fluorine (F) and cadmium (Cd) have raised significant concerns regarding their impacts on human health but the relationship between F and Cd in soil-wheat plant system in an oasis region has not been investigated. This paper aims to study the accumulation and interaction of F and total Cd in the soil-wheat plant system while considering the potential risks of F and Cd to human health. Soil samples were collected from wastewater-irrigated oasis regions, Dongdagou and Xidagou...
October 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28386893/cheap-non-toxic-non-corrosive-method-of-glass-cleaning-evaluated-by-contact-angle-afm-and-sem-edx-measurements
#15
Tania Dey, Daragh Naughton
Glass surface cleaning is the very first step in advanced coating deposition and it also finds use in conserving museum objects. However, most of the wet chemical methods of glass cleaning use toxic and corrosive chemicals like concentrated sulfuric acid (H2SO4), piranha (a mixture of concentrated sulfuric acid and 30% hydrogen peroxide), and hydrogen fluoride (HF). On the other hand, most of the dry cleaning techniques like UV-ozone, plasma, and laser treatment require costly instruments. In this report, five eco-friendly wet chemical methods of glass cleaning were evaluated in terms of contact angle (measured by optical tensiometer), nano-scale surface roughness (measured by atomic force microscopy or AFM), and elemental composition (measured by energy dispersive x-ray spectroscopy or SEM-EDX)...
April 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28374970/human-bj-fibroblasts-is-an-alternative-to-mouse-balb-c-3t3-cells-in-in-vitro-neutral-red-uptake-assay
#16
Marika Mannerström, Tarja Toimela, Jertta-Riina Sarkanen, Tuula Heinonen
The OECD GD 129 BALB/c 3T3 Neutral Red Uptake (NRU) assay is a standardized test method for estimating starting dose for an acute oral systemic toxicity test in rodents. Mouse BALB/c 3T3 fibroblasts are the most commonly used cells in the NRU assay. We have previously transferred and validated BALB/c 3T3 NRU assay in our GLP laboratory. Subsequently, in order to obtain more human relevant cytotoxicity data, we performed an intra-laboratory validation using human BJ fibroblasts in the NRU assay instead of mouse BALB/c 3T3 fibroblasts...
April 4, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28374673/the-influence-of-sodium-fluoride-on-the-growth-of-ameloblasts-and-kidney-proximal-tubular-cells
#17
S Wahluyo, K Ismiyatin, B Purwanto, I S Mukono
Fluoride has toxic potential particularly for teeth, bones, and kidney. This study was aimed to investigate the NaF exposure effects on the growth of ameloblasts and kidney proximal tubular cells. Adult male healthy rats were used as experiment models, divided into control and NaF-induced groups. The expression of amelogenin, Bcl-2, and caspase-3 were significantly different in the control and NaF-induced group (P < 0.05). There was no correlation among these proteins in the control group but significant correlation in the NaF-induced group (r = 0...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28355051/mofabric-electrospun-nanofiber-mats-from-pvdf-uio-66-nh2-for-chemical-protection-and-decontamination
#18
Annie Xi Lu, Monica McEntee, Matthew A Browe, Morgan G Hall, Jared B DeCoste, Gregory W Peterson
Textiles capable of capture and detoxification of toxic chemicals, such as chemical-warfare agents (CWAs), are of high interest. Some metal-organic frameworks (MOFs) exhibit superior reactivity toward CWAs. However, it remains a challenge to integrate powder MOFs into engineered materials like textiles, while retaining functionalities like crystallinity, adsorptivity, and reactivity. Here, we present a simple method of electrospinning UiO-66-NH2, a zirconium MOF, with polyvinylidene fluoride (PVDF). The electrospun composite, which we refer to as "MOFabric", exhibits comparable crystal patterns, surface area, chlorine uptake, and simulant hydrolysis to powder UiO-66-NH2...
April 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28284958/risk-assessment-of-fluoride-exposure-in-drinking-water-of-tunisia
#19
Wiem Guissouma, Othman Hakami, Abdul Jabbar Al-Rajab, Jamila Tarhouni
The presence of fluoride in drinking water is known to reduce dental cavities among consumers, but an excessive intake of this anion might leads to dental and skeletal fluorosis. This study reports a complete survey of the fluoridated tap water taken from 100 water consumption points in Tunisia. The fluoride concentrations in tap water were between 0 and 2.4 mg L(-1). Risk assessment of Fluoride exposure was assessed depending on the age of consumers using a four-step method: hazard identification, toxicity reference values selection (TRVs), daily exposure assessment, and risk characterization...
March 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28266088/fluoride-or-and-aluminum-induced-toxicity-in-guinea-pig-teeth-with-the-low-expression-of-dentine-phosphoprotein
#20
Tianlong Han, Min Wang, Chunfang Cao, Huacheng Chen, Guanghe Zhang, Liping Wang, Jundong Wang
This study investigated the damage and expression of dentine phosphoprotein (DPP) in guinea pig teeth by the administration of fluoride (F) or/and aluminum (Al). Fifty-two guinea pigs were divided randomly into four groups (control, F, Al, and F+Al). F (150 mg NaF/L) or/and Al (300 mg AlCl3 /L) were added in their drinking water for 90 days. The levels of F ion, dentine sialophosphoprotein (DSPP) gene, and DPP protein in incisor and molar were determined, respectively. The results showed that the concentrations of F ion in F and F+Al groups were increased significantly...
March 7, 2017: Journal of Biochemical and Molecular Toxicology
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