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Fluoride toxicity

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https://www.readbyqxmd.com/read/29331911/enhanced-photocatalytic-degradation-of-sulfamethoxazole-by-zinc-oxide-photocatalyst-in-the-presence-of-fluoride-ions-optimization-of-parameters-and-toxicological-evaluation
#1
Amir Mirzaei, Laleh Yerushalmi, Zhi Chen, Fariborz Haghighat, Jianbo Guo
The presence of antibiotics in water bodies has received increasing attention since they are continuously introduced and detected in the environment and may cause unpredictable environmental hazards and risks. The photocatalytic degradation of sulfamethoxazole (SMX) by ZnO in the presence of fluoride ions (F-ZnO) was evaluated. The effects of operating parameters on the efficiency of SMX removal were investigated by using response surface methodology (RSM). Under the optimum condition, i.e. photocatalyst dosage = 1...
January 11, 2018: Water Research
https://www.readbyqxmd.com/read/29297143/curse-of-fluorosis
#2
REVIEW
M M Patil, Bhavana B Lakhkar, Shailaja S Patil
Fluoride was identified to have caries preventive properties and was widely used for fluoridation of water since 1940, especially in developed countries. After this there was sudden increase in the use of fluorides in food items and in oral medicinal products like toothpastes and mouth washes. Inadvertent use of above has lead to increase in fluorosis as a public health problem. In many places high fluorides are naturally present in earth crust leading to high water fluoride content increasing the risk of fluorosis...
January 3, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29297101/contrasting-growth-properties-of-nocardioides-js614-on-threedifferent-vinyl-halides
#3
Anne E Taylor, Peter J Bottomley, Lewis Semprini
Ethene (ETH)-grown inocula of Nocardioides JS614 grow on vinyl chloride (VC), vinyl fluoride (VF), or vinyl bromide (VB) as the sole carbon and energy source, with faster growth rates and higher cell yields on VC and VF than on VB. However, whereas acetate-grown inocula of JS614 grow on VC and VF after a lag period, growth on VB did not occur unless supplemental ethene oxide (EtO) was present in the medium. Despite inferior growth on VB, the maximum rate of VB consumption by ETH-grown cells was ~ 50% greater than the rates of VC and VF consumption, but Br- release during VB consumption was non-stoichiometric with VB consumption (~ 66%) compared to 100% release of Cl- and F- during VC and VF consumption...
January 3, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29278284/co-exposure-to-fluoride-and-sulfur-dioxide-on-histological-alteration-and-dna-damage-in-rat-brain
#4
Chong Wang, Chen Liang, Junjie Ma, Ram Kumar Manthari, Ruiyan Niu, Jinming Wang, Jundong Wang, Jianhai Zhang
Fluoride (F) and sulfur dioxide (SO2 ) are the two common environmental contaminants that are associated with neurotoxicity. The present study was conducted to explore individual and combined exposure effects of F and SO2 on histological alteration and DNA damage in rat brain. For this, male Wistar albino rats were exposed to sodium fluoride (100 mg/L NaF) and sulfur dioxide (39.3 mg/m3 ) individually and in combination for 8 weeks. Histological alteration in brain is evaluated by hematoxylin-eosin staining, showed shrunken neurons, darkly stained small nucleus and decreased cell numbers in F and SO2 exposed groups...
December 26, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29275851/biocompatibility-and-osteogenic-calcification-potential-of-casein-phosphopeptide-amorphous-calcium-phosphate-fluoride
#5
Alaa E Dawood, David J Manton, Peter Parashos, Rebecca H Wong, William Singleton, James A Holden, Neil M O'Brien-Simpson, Eric C Reynolds
INTRODUCTION: Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and CPP-ACP with fluoride (CPP-ACFP) have been shown to provide bioavailable ions to promote mineralization. Hence, the aim of this study was to evaluate the materials' biocompatibility and osteogenic/calcification potential for endodontic applications. METHODS: Human and mouse osteoblast-like and fibroblast-like cell lines were incubated with 0.05%-3.0% w/v CPP-ACP and CPP-ACFP, and toxicity, proliferation, alkaline phosphatase, interleukin (IL)-1α, and IL-6 production, collagen type I, osteocalcin, and osteopontin production, and mineralization/calcification were determined...
December 21, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29273675/vitamin-e-and-lycopene-reduce-coal-burning-fluorosis-induced-spermatogenic-cell-apoptosis-via-oxidative-stress-mediated-jnk-and-erk-signaling-pathways
#6
Yuan Tian, Yuehai Xiao, Bolin Wang, Chao Sun, Kaifa Tang, Fa Sun
Although fluoride has been widely used in toothpaste, mouthwash, and drinking water to prevent dental caries, the excessive intake of fluoride can cause fluorosis which is associated with dental, skeletal, and soft tissue fluorosis. Recent evidences have drawn the attention to its adverse effects on male reproductive system that include spermatogenesis defect, sperm count loss, and sperm maturation impairment. Fluoride induces oxidative stress through the activation of mitogen activated protein kinase (MAPK) cascade which can lead to cell apoptosis...
December 22, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29248268/trifluoroacetic-acid-three-times-the-fluoride-three-times-the-toxicity
#7
Christie Sun, Bryan Corbett
Trifluoroacetic acid (TFAA) is a carboxylic acid, similar to acetic acid, used industrially and in laboratories. There is a paucity of data regarding exposure and the concern is that toxicity may mimic that of hydrofluoric acid (HF), causing electrolyte abnormalities, dysrhythmia, and cardiac arrest. We report a case of a 27-year-old male that presents with a dermal exposure to TFAA. His exam was remarkable for a 4% body surface area partial thickness burn to the right forearm. There were no initial electrolyte abnormalities or dysrhythmias and the patient was admitted to telemetry monitoring overnight...
December 12, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29237131/adverse-effects-of-silver-diamine-fluoride-treatment-among-preschool-children
#8
D Duangthip, M H T Fung, M C M Wong, C H Chu, E C M Lo
This randomized clinical trial aimed to compare the adverse effects and parental satisfaction following the different regimes of silver diamine fluoride (SDF) treatment among preschool children. A total of 888 preschool children who had active dentin caries received different SDF application regimes: group 1, 12% SDF applied annually; group 2, 12% SDF applied semiannually; group 3, 38% SDF applied annually; and group 4, 38% SDF applied semiannually. Information on adverse effects-including tooth or gum pain, gum swelling, gum bleaching, and systemic toxicity-was collected through a parent-reported questionnaire within 1 wk after every SDF or placebo application...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29227109/fast-and-environmentally-friendly-microfluidic-technique-for-the-fabrication-of-polymer-microspheres
#9
Yanlin Zhang, Robert W Cattrall, Spas D Kolev
This paper reports on a novel microfluidic technique for the fabrication of microspheres of synthetic polymers including poly(vinyl chloride) (PVC), poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP), poly(lactic acid) (PLA), and polystyrene (PS). The polymers are dissolved in tetrahydrofuran (THF) and the method is based on the diminished solubility of THF in a 20% (w/v) NaCl solution which allows the formation of droplets of the polymer solution. These polymer solution droplets are generated in a microfluidic system and their desolvation is accomplished within seconds by allowing the droplets to rise by buoyancy through a NaCl solution with a concentration lower than 15%...
December 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29215057/mechanochemical-mineralization-of-very-persistent-fluorocarbon-surfactants-%C3%A2-6-2-fluorotelomer-sulfonate-6-2fts-as-an-example
#10
Mengnan Lu, Giovanni Cagnetta, Kunlun Zhang, Jun Huang, Gang Yu
Fluorinated organic chemicals have a wide variety of industrial and consumer applications. For long time perfluorooctane sulfonate and perfluorooctanoic acid have been used as precursors for manufacture of such chemicals. However, these C8 chain compounds have been demonstrated to be toxic, persistent, and bioaccumulative, thus inducing their phase-out. Currently, C6 telomer based fluorocarbon surfactants are considered better alternatives to C8 products because of their low bioaccumulability. But, their high persistency suggests that in the near future their concentrations will increase in the environment and in industrial waste...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29213094/sodium-fluoride-exposure-exerts-toxic-effects-on-porcine-oocyte-maturation
#11
Shuang Liang, Zheng-Wen Nie, Minghui Zhao, Ying-Jie Niu, Kyung-Tae Shin, Xiang-Shun Cui
Excessive long-term fluoride intake is associated with several health problems, including infertility. However, limited information is available on the toxic effects of fluoride exposure on the female reproductive system, especially oocyte maturation. In this study, we investigated the toxic effect of sodium fluoride (NaF) exposure on porcine oocyte maturation and its possible underlying mechanisms. Our results showed that NaF exposure during porcine oocyte maturation inhibited cumulus cell expansion and impaired polar body extrusion...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29185024/sirt1-overexpression-suppresses-fluoride-induced-p53-acetylation-to-alleviate-fluoride-toxicity-in-ameloblasts-responsible-for-enamel-formation
#12
Maiko Suzuki, Atsushi Ikeda, John D Bartlett
Low-dose fluoride is an effective caries prophylactic, but high-dose fluoride is an environmental health hazard that causes skeletal and dental fluorosis. Treatments to prevent fluorosis and the molecular pathways responsive to fluoride exposure remain to be elucidated. Previously we showed that fluoride activates SIRT1 as an adaptive response to protect cells. Here, we demonstrate that fluoride induced p53 acetylation (Ac-p53) [Lys379], which is a SIRT1 deacetylation target, in ameloblast-derived LS8 cells in vitro and in enamel organ in vivo...
November 28, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29178720/lipopolysaccharide-and-lipoteichoic-acid-binding-by-antimicrobials-used-in-oral-care-formulations
#13
John Christian Haught, Sancai Xie, Ben Circello, Cheryl S Tansky, Deepa Khambe, Yiping Sun, Yakang Lin, Koti Sreekrishna, Malgorzata Klukowska, Tom Huggins, Donald J White
PURPOSE: To study the reactivity of lipopolysaccharide (LPS) and lipoteichoic acid (LTA) with the cationically charged agents cetylpyridinium chloride, stannous fluoride, and the non-cationic agent triclosan. We also assessed the effect of these agents to inhibit LPS and LTA binding to cellular Toll-like Receptors (TLRs) in vitro. METHODS: The ability of these antimicrobials to bind with LPS and/or LTA was assessed in both the Limulus amebocyte lysate and BODIPY-TR-cadaverine dye assays...
December 2016: American Journal of Dentistry
https://www.readbyqxmd.com/read/29156736/effects-of-sodium-fluoride-on-blood-cellular-and-humoral-immunity-in-mice
#14
Hongrui Guo, Ping Kuang, Qin Luo, Hengmin Cui, Huidan Deng, Huan Liu, Yujiao Lu, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao
Exposure to high fluorine can cause toxicity in human and animals. Currently, there are no systematic studies on effects of high fluorine on blood cellular immunity and humoral immunity in mice. We evaluated the alterations of blood cellular immunity and humoral immunity in mice by using flow cytometry and ELISA. In the cellular immunity, we found that sodium fluoride (NaF) in excess of 12 mg/Kg resulted in a significant decrease in the percentages of CD3(+), CD3(+)CD4(+), CD3(+)CD8(+) T lymphocytes in the peripheral blood...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29131611/synthesis-and-in-vitro-evaluation-of-monodisperse-amino-functional-polyester-dendrimers-with-rapid-degradability-and-antibacterial-properties
#15
Patrik Stenström, Erik Hjorth, Yuning Zhang, Oliver C J Andrén, Simon Guette-Marquet, Marianne Schultzberg, Michael Malkoch
Amine functional polymers, especially cationically charged, are interesting biomacromolecules for several reasons, including easy cell membrane entrance, their ability to escape endosomes through the proton sponge effect, spontaneous complexation and delivery of drugs and siRNA, and simple functionalization in aqueous solutions. Dendrimers, a subclass of precision polymers, are monodisperse and exhibit a large and exact number of peripheral end groups in relation to their size and have shown promise in drug delivery, biomedical imaging and as antiviral agents...
November 22, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29113434/similar-active-sites-and-mechanisms-do-not-lead-to-cross-promiscuity-in-organophosphate-hydrolysis-implications-for-biotherapeutic-engineering
#16
Miha Purg, Mikael Elias, Shina Caroline Lynn Kamerlin
Organophosphate hydrolases are proficient catalysts of the breakdown of neurotoxic organophosphates, and have great potential as both biotherapeutics for treating acute organophosphate toxicity, and as bioremediation agents. Yet proficient organophosphatases such as serum paraoxonase 1 (PON1) and the organophosphate-hydrolyzing lactonase SsoPox are unable to hydrolyze organophosphates with challenging leaving groups such as diisopropyl fluorophosphate (DFP) or venomous agent X (VX), creating a major challenge for enzyme design...
November 7, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29093461/in-vivo-like-3-d-model-for-sodium-nitrite-and-acrylamide-induced-hepatotoxicity-tests-utilizing-hepg2-cells-entrapped-in-micro-hollow-fibers
#17
Qiang Chu, Yiying Zhao, Xuer Shi, Wen Han, Yanzhen Zhang, Xiaodong Zheng, Jing Zhu
To address the need for a high throughput toxicity test in the modern food industry, an in vivo-like 3-D cell model was constructed in this study to provide an alternative to controversial long-term animal models and to improve the sensitivity and accuracy of the traditional monolayer model. The model formed cell cylindroids within polyvinylidene fluoride (PVDF) hollow fibers and therefore mimicked the microenvironment of liver tissue. Microscopy methods were used, and liver-specific functions were measured to demonstrate the superiority of the model compared to the monolayer model, as well as to optimize the model for best cell performances...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29091818/fluoride-a-review-of-pre-clinical-and-clinical-studies
#18
REVIEW
Divya Sharma, Aarti Singh, Kanika Verma, Sarvesh Paliwal, Swapnil Sharma, Jaya Dwivedi
Fluoride is ubiquitous in environment and profound in bones, teeth and calcified tissues of human body. Fluoride has been the topic of regular discussion and investigations. Besides its toxicity, fluoride has also been examined for its beneficial effects like prevention and treatment of tooth decay, microbial infection, inflammation, cancer, occurrence of renal stone and many more. Since last many decades, several efforts have been made at pre-clinical and clinical level to understand role of fluoride in biological system...
October 24, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29066833/effects-of-the-discharge-of-uranium-mining-effluents-on-the-water-quality-of-the-reservoir-an-integrative-chemical-and-ecotoxicological-assessment
#19
Carla Rolim Ferrari, Heliana de Azevedo Franco do Nascimento, Suzelei Rodgher, Tito Almeida, Armando Luiz Bruschi, Marcos Roberto Lopes do Nascimento, Rodrigo Leandro Bonifácio
The water quality of the Antas reservoir, under the influence of treated effluents from a uranium mining area Ore Treatment Unit (UTM) with acid mine drainage, was investigated. Samples were collected every 3 months from the Antas reservoir (CAB, P41-E and P14) and from the UTM (P41-S). Chemical and acute 48 h toxicity tests using Ceriodaphnia silvestrii and Daphnia magna analyses were carried out to determine the potential environmental risks due to discharging the uranium mine effluents into this reservoir...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29048704/hydroxyapatite-decreases-cytotoxicity-of-a-glass-ionomer-cement-by-calcium-fluoride-uptake-in-vitro
#20
Casiano Del Angel-Mosqueda, Rene Hernandez-Delgadillo, Osvelia E Rodríguez-Luis, María T Ramírez-Rodríguez, Silvia Munguía-Moreno, Norma V Zavala-Alonso, Juan M Solís-Soto, María A A Nakagoshi-Cepeda, Rosa I Sánchez-Nájera, Sergio E Nakagoshi-Cepeda, Claudio Cabral-Romero
BACKGROUND: Glass ionomer cements (GICs) are widely used in dentistry because of their remineralizing and cariostatic potential induced by fluoride. In vitro studies have reported cell toxicity triggered by GICs; however, the influence of hydroxyapatite (HAp) must be considered. The aim of this study was to evaluate the effect of HAp in decreasing the cytotoxicity of the GIC 3M Vitrebond in vitro. METHODS: Samples of 3M Vitrebond (powder, liquid and light-cured) were incubated in Dulbecco's modified Eagle's medium-Ham's F12 (DMEM-F12) for 24 hours at 37°C...
October 14, 2017: Journal of Applied Biomaterials & Functional Materials
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