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Fluoride toxicity

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https://www.readbyqxmd.com/read/28937959/prenatal-fluoride-exposure-and-cognitive-outcomes-in-children-at-4-and-6-12-years-of-age-in-mexico
#1
Morteza Bashash, Deena Thomas, Howard Hu, E Angeles Martinez-Mier, Brisa N Sanchez, Niladri Basu, Karen E Peterson, Adrienne S Ettinger, Robert Wright, Zhenzhen Zhang, Yun Liu, Lourdes Schnaas, Adriana Mercado-García, Martha María Téllez-Rojo, Mauricio Hernández-Avila
BACKGROUND: Some evidence suggests that fluoride may be neurotoxic to children. Few of the epidemiologic studies have been longitudinal, had individual measures of fluoride exposure, addressed the impact of prenatal exposures or involved more than 100 participants. OBJECTIVE: Our aim was to estimate the association of prenatal exposure to fluoride with offspring neurocognitive development. METHODS: We studied participants from the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) project...
September 19, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28927274/fluoride-induced-autophagy-via-the-regulation-of-mtor-phosphorylation-in-mice-leydig-cells
#2
Jianhai Zhang, Yuchen Zhu, Yan Shi, Yongli Han, Chen Liang, Zhiyuan Feng, Heping Zheng, Michelle Eng, Jundong Wang
Abstracts:Fluoride is known to impair testicular functions and decrease testosterone levels, yet the underlying mechanisms remain inconclusive. The objective of this study is to investigate the roles of autophagy in fluoride-induced male reproductive toxicity by both in vivo and in vitro Leydig cell models. Using Transmission Electron Microscopy (TEM) and Monodansylcadaverine (MDC) staining, we observed increasing numbers of autophagosomes in testicular tissue, especially in Leydig cells of fluoride-exposed mice...
September 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28918527/alterations-in-epididymal-proteomics-and-antioxidant-activity-of-mice-exposed-to-fluoride
#3
Zilong Sun, Sujuan Li, Yuxiang Yu, Hongyu Chen, Mohammad Mehdi Ommati, Ram Kumar Manthari, Ruiyan Niu, Jundong Wang
It is well known that high fluoride results in low fertility. Epididymis is the important place for spermatozoa maturation, which is essential for successful fertilization. In the previous studies, fluoride was reported to damage the epididymal structure of mouse and rabbit. However, the mechanism underlying sodium fluoride (NaF)-induced epididymal toxicity has not yet been well elucidated. The aim of this study is to explore the global protein alterations in epididymis of mice exposed to NaF using the iTRAQ technique...
September 16, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28913781/effects-of-fluoride-and-or-sulfur-dioxide-on-morphology-and-dna-integrity-in-rats-hepatic-tissue
#4
Chen Liang, Yan Gao, Yangfei Zhao, Ram Kumar Manthari, Junjie Ma, Ruiyan Niu, Jinming Wang, Jianhai Zhang, Jundong Wang
This study was aimed to evaluate the toxic effects of fluoride (F) and/or sulfur dioxide (SO2) on morphology and DNA integrity in liver of male rats. For this, 96 Wistar rats (12-week-old) were randomly divided into four groups after 1-week adaptive breeding: the control group, treated with deionized water; the NaF group, administered high F (100 mg NaF/L in the drinking water); the SO2 group, with sulfur dioxide in ambient air (15 ppm SO2, 4 h/day); and NaF + SO2 group, treated with high F and sulfur dioxide together for 8 consecutive weeks...
September 14, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28912098/melatonin-mediated-upregulation-of-sirt3-attenuates-sodium-fluoride-induced-hepatotoxicity-by-activating-the-mt1-pi3k-akt-pgc-1%C3%AE-signaling-pathway
#5
Chao Song, Jiamin Zhao, Beibei Fu, Dan Li, Tingchao Mao, Wei Peng, Haibo Wu, Yong Zhang
Mitochondrial reactive oxygen species (ROS) production has been implicated in the pathogenesis of fluoride toxicity in liver. Melatonin, an indolamine synthesized in the pineal gland, was previously shown to protect against sodium fluoride (NaF)-induced hepatotoxicity. This study investigated the protective effects of melatonin pretreatment on NaF-induced hepatotoxicity and elucidates the potential mechanism of melatonin-mediated protection. Reducing mitochondrial ROS by melatonin substantially attenuated NaF-induced NADPH oxidase 4 (Nox4) upregulation and cytotoxicity in L-02 cells...
September 11, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28894868/rare-earth-ions-enhanced-near-infrared-fluorescence-of-ag2s-quantum-dots-for-the-detection-of-fluoride-ions-in-living-cells
#6
Caiping Ding, Xuanyu Cao, Cuiling Zhang, Tangrong He, Nan Hua, Yuezhong Xian
In this work, a novel phenomenon was discovered that the fluorescence intensity of silver sulfide quantum dots (Ag2S QDs) could be enhanced in the presence of rare earth ions through aggregation-induced emission (AIE). Based on the strong coordination between rare earth ions and F(-), a facile and label-free strategy was developed for the detection of F(-) in living cells. Ag2S QDs were synthesized using 3-mercaptopropionic acid as sulfur source and stabilizer in aqueous solution. The near infrared (NIR) emitting QDs exhibited excellent photostalilty, high quantum yield and low toxic...
September 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28880551/cationic-poly-benzyl-ether-s-as-self-immolative-antimicrobial-polymers
#7
Cansu Ergene, Edmund F Palermo
Self-immolative polymers (SIMPs) are macromolecules that spontaneously undergo depolymerization into small molecules when triggered by specific external stimuli. We report here the first examples of antimicrobial SIMPs with potent, rapid, and broad-spectrum bactericidal activity. Their antibacterial and hemolytic activities were examined as a function of cationic functionality. Polymers bearing primary ammonium cationic groups showed more potent bactericidal activity against Escherichia coli, relative to tertiary and quaternary ammonium counterparts, whereas the quaternary ammonium polymers showed the lowest hemolytic toxicity...
September 22, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28867804/fviia-stf-and-thrombin-inhibitory-activities-of-compounds-isolated-from-microcystis-aeruginosa-k-139
#8
Andrea Roxanne J Anas, Akane Mori, Mineka Tone, Chiaki Naruse, Anna Nakajima, Hirohiko Asukabe, Yoshiaki Takaya, Susumu Y Imanishi, Tomoyasu Nishizawa, Makoto Shirai, Ken-Ichi Harada
The rise of bleeding and bleeding complications caused by oral anticoagulant use are serious problems nowadays. Strategies that block the initiation step in blood coagulation involving activated factor VII-tissue factor (fVIIa-TF) have been considered. This study explores toxic Microcystis aeruginosa K-139, from Lake Kasumigaura, Ibaraki, Japan, as a promising cyanobacterium for isolation of fVIIa-sTF inhibitors. M. aeruginosa K-139 underwent reversed-phase solid-phase extraction (ODS-SPE) from 20% MeOH to MeOH elution with 40%-MeOH increments, which afforded aeruginosin K-139 in the 60% MeOH fraction; micropeptin K-139 and microviridin B in the MeOH fraction...
August 30, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28864413/effect-of-sodium-fluoride-on-the-sperm-mitochondrial-dna-in-mice
#9
Zilong Sun, Xingchen Xue, Yuliang Zhang, Ruiyan Niu, Jundong Wang
Previous studies demonstrated that fluoride, as a widespread environmental pollutant, induced the reproductive toxicity at high dose. Besides the decrease of sperm characteristics like concentration, survival, and sperm motility, it was found that high fluoride induced the destructive mitochondrial ultrastructure and decreased ATP production from mitochondrial respiration. However, whether fluoride exposure can damage the mitochondrial DNA (mtDNA) of sperm is still unknown. In this study, 100 male mice were randomly divided into four groups 25 each, which were administrated with the distilled water containing 0, 25, 50 and 100 mg L(-1) NaF, respectively for 60 days...
August 30, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28855553/toxic-fluoride-gas-emissions-from-lithium-ion-battery-fires
#10
Fredrik Larsson, Petra Andersson, Per Blomqvist, Bengt-Erik Mellander
Lithium-ion battery fires generate intense heat and considerable amounts of gas and smoke. Although the emission of toxic gases can be a larger threat than the heat, the knowledge of such emissions is limited. This paper presents quantitative measurements of heat release and fluoride gas emissions during battery fires for seven different types of commercial lithium-ion batteries. The results have been validated using two independent measurement techniques and show that large amounts of hydrogen fluoride (HF) may be generated, ranging between 20 and 200 mg/Wh of nominal battery energy capacity...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28846973/developmental-fluoride-exposure-influenced-rat-s-splenic-development-and-cell-cycle-via-disruption-of-the-erk-signal-pathway
#11
Yanqin Ma, Kankan Zhang, Fengjun Ren, Jundong Wang
Excessive fluoride exposure has been reported to cause damage to spleen. Neonatal period is characterized by rapid proliferation and differentiation of lymphocyte in the spleen. Children may be more sensitive to the toxicity of fluoride compared to the adults. The aim of this study was to investigate the effects of postnatal exposure (from neonatal period to early adulthood) to fluoride on the development of spleen on a regular basis and the underlying signal pathway. Results showed a marked decrease in spleen weight index and altered morphology in the spleen of fluoride-treated group on PND-84, which reflected fluoride inhibition of the development of spleen...
August 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28843560/smartphone-coupled-handheld-array-reader-for-real-time-toxic-gas-detection
#12
Jasmine Pramila Devadhasan, Dami Kim, Do Young Lee, Sanghyo Kim
Smartphones and related accessories are rapidly expanding their applications in various fields. Herein we developed a smartphone coupled handheld array reader with the integration of complementary metal oxide (CMOS) image sensor for detecting various toxic gases by colorimetric monitoring approach. In this study, toxic gases such as hydrogen fluoride (HF), chlorine (Cl2), ammonia (NH3), and formaldehyde (CH2O) were detected using titanium nanoparticles (TiO2 NPs) blended poly (vinyl alcohol) (PVA) hydrogel test strips, which were patterned with chemically responsive dyes...
September 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28840484/pulmonary-fluorosis-a-review
#13
Jaishabanu Ameeramja, Ekambaram Perumal
The increased industrialization and improvised human lifestyle lead to a surge in environmental pollution nowadays. Even the chemicals which are known as prophylactic agents were currently liable to be toxic. One among them is inorganic fluoride whose wider application in numerous processes makes it as an inevitable environmental contaminant and industrial pollutant. Although the systemic toxicity of fluoride has been extensively studied, still there is lacuna in the field of pulmonary fluoride toxicity. Hence, we have focused on the molecular mechanism of action of fluoride compounds on pulmonary system...
August 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28812227/effects-of-fluoride-on-surface-structure-of-primary-culture-leydig-cells-in-mouse
#14
Jian Li, Yan Shi, Hua Fan, Yanyan Li, Yuchen Zhu, Xijun Lin, Jianhai Zhang
Fluoride (F) is known to induce reproduction toxicity, and the elucidation of its underlying mechanisms is an ongoing research. These findings aim to provide deeper insights into roles of soduim fluoride (NaF) in testis damage, which could contribute to a better understanding of fluoride-induced male reproductive toxicity. The Leydig cells were administrated by 0, 5, 10, and 20 mg/L NaF for 24 h, respectively. Scanning electron microscope was used to identify the change of surface structure in the Leydig cells...
August 15, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28792197/transparent-copper-loaded-chitosan-silica-antibacterial-coatings-with-long-term-efficacy
#15
Debirupa Mitra, Min Li, En-Tang Kang, Koon Gee Neoh
Bacteria-contaminated inanimate surfaces within hospitals and clinics result in transmission of pathogens via direct or indirect contact, leading to increased risk of healthcare-associated infections (HAI). The use of antibacterial coatings is a potential way of reducing the bacterial burden, but many surfaces such as instrument panels and monitors necessitate the coatings to be transparent while being highly antibacterial. In this work, silica nanoparticles (SiO2 NPs) were first grown over a layer of acrylated quaternized chitosan (AQCS) covalently immobilized on commercially available transparent poly(vinyl fluoride) (PVF) films...
August 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28792058/%C3%AE-dicyanovinyl-substituted-porphyrinogen-synthesis-a-reversible-sensor-for-picric-acid-among-explosives-and-a-unique-sensor-for-cyanide-and-fluoride-ions-by-switching-between-various-porphyrinoid-states
#16
Mandeep K Chahal, Muniappan Sankar
β-Dicyanovinyl substituted porphyrinogen (OxP-MN) was synthesized and utilized as a novel multifunctional sensor for the detection of biologically and environmentally important analytes. OxP-MN (1) acts as a selective and reversible probe for rapid colorimetric detection of picric acid (PA) among other nitroaromatics by switching between two porphyrinoid states. This system displayed a higher β2 value of 1.7 × 10(8) M(-2) and was able to detect PA down to 1.12 ppm (4.99 μM). β-Dicyanovinyl substituted porphyrinogen (OxP-MN) reported here contains a porphyrinogen anion binding site and a dicyanovinyl group as a cyanide-dependent reactive subunit...
September 12, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28754999/identification-of-an-operon-involved-in-fluoride-resistance-in-enterobacter-cloacae-frm
#17
Xiaoqing Liu, Jian Tian, Lihui Liu, Tao Zhu, Xiaoxia Yu, Xiaoyu Chu, Bin Yao, Ningfeng Wu, Yunliu Fan
Fluorine is ubiquitous and the most active non-metal element in nature. While many microorganisms have developed fluoride resistance as a result of the widespread and prolonged application of oral hygiene products, the mechanisms used by these organisms to overcome fluoride toxicity are incompletely understood. In this study, a fluoride-resistant strain, Enterobacter cloacae FRM, was identified which could grow well at a fluoride concentration of 4,000 mg/L. According to comparative genomics, transcriptome under fluoride stress, and sequence analyses of two fluoride-resistant fosmid clones, the genomic island GI3 was found to be important for fluoride resistance...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28748043/fluoride-resistance-in-streptococcus-mutans-a-mini-review
#18
REVIEW
Ying Liao, Bernd W Brandt, Jiyao Li, Wim Crielaard, Cor Van Loveren, Dong Mei Deng
For decades, fluoride has been used extensively as an anti-caries agent. It not only protects dental hard tissue, but also inhibits bacterial growth and metabolism. The antimicrobial action of fluoride is shown in three main aspects: the acidogenicity, acidurance, and adherence to the tooth surface. To counteract the toxic effect of fluoride, oral bacteria are able to develop resistance to fluoride through either phenotypic adaptation or genotypic changes. Strains that acquire fluoride resistance through the latter route show stable resistance and can usually resist much higher fluoride levels than the corresponding wild-type strain...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/28719589/an-excited-state-underlies-gene-regulation-of-a-transcriptional-riboswitch
#19
Bo Zhao, Sharon L Guffy, Benfeard Williams, Qi Zhang
Riboswitches control gene expression through ligand-dependent structural rearrangements of the sensing aptamer domain. However, we found that the Bacillus cereus fluoride riboswitch aptamer adopts identical tertiary structures in solution with and without ligand. Using chemical-exchange saturation transfer (CEST) NMR spectroscopy, we revealed that the structured ligand-free aptamer transiently accesses a low-populated (∼1%) and short-lived (∼3 ms) excited conformational state that unravels a conserved 'linchpin' base pair to signal transcription termination...
September 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28687488/rescuing-fluoride-induced-damages-in-liver-with-gamma-aminobutyric-acid
#20
Haoyue Yang, Ronge Xing, Song Liu, Huahua Yu, Pengcheng Li
Fluorine poisoning affects human health all over the world and an urgent task is to develop alleviative medicine to recover or ameliorate the damages to the body. Here we studied the effects of gamma-aminobutyric acid (GABA), a liver protector reported previously, on fluoride-induced damage in the mouse liver. Through microscope imaging of the liver tissue, TUNEL immunostaining, real-time RT-PCR, enzyme immunoassay and colorimetric method, we found that GABA supplementation prevented the metabolic toxicity caused by fluoride treatment in mice...
September 9, 2017: Biochemical and Biophysical Research Communications
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