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Fluoride toxicity

Joanna A Ruszkiewicz, Adi Pinkas, Mahfuzur R Miah, Rebecca L Weitz, Michael J A Lawes, Ayodele J Akinyemi, Omamuyovwi M Ijomone, Michael Aschner
Due to many advantages Caenorhabditis elegans (C. elegans) has become a preferred model of choice in many fields, including neurodevelopmental toxicity studies. This review discusses the benefits of using C. elegans as an alternative to mammalian systems and gives examples of the uses of the nematode in evaluating the effects of major known neurodevelopmental toxins, including manganese, mercury, lead, fluoride, arsenic and organophosphorus pesticides. Reviewed data indicates numerous similarities with mammals in response to these toxins...
March 14, 2018: Toxicology and Applied Pharmacology
İlkay Aydogan, Mehmet Akif Karslı, Mehmet Başalan, Ebru Yıldırım, Miyase Çınar, Gökhan Şen, Tugce Sümer
We evaluated the effects of dietary epigallocatechin gallate (EGCG) on the performance, biochemical parameters, and liver histopathology of fluoride-intoxicated broiler chickens. In total, 160 1-day-old male broiler chicks (Ross PM3 strain) were collected and assigned to four groups (40 animals each), with four replicates. The control group received a basal diet; the F group received 800 mg/kg fluoride; the EGCG group received 400 mg/kg EGCG; and the EGCG+F group received 400 mg/kg EGCG and 800 mg/kg fluoride...
March 16, 2018: Biological Trace Element Research
Ane Urtiaga, Alvaro Soriano, Jordi Carrillo-Abad
The concerns about the undesired impacts on human health and the environment of long chain perfluorinated alkyl substances (PFASs) have driven industrial initiatives to replace PFASs by shorter chain fluorinated homologues. 6:2 fluorotelomer sulfonic acid (6:2 FTSA) is applied as alternative to PFOS in metal plating and fluoropolymer manufacture. This study reports the electrochemical treatment of aqueous 6:2 FTSA solutions on microcrystalline BDD anodes. Bench scale batch experiments were performed, focused on assessing the effect of the electrolyte and the applied current density (5-600 A m-2 ) on the removal of 6:2 FTSA, the reduction of total organic carbon (TOC) and the fluoride release...
March 7, 2018: Chemosphere
Chunxia Li, Lili Xu, Zihua Liu, Zhengquan Li, Zewei Quan, Abdulaziz A Al Kheraif, Jun Lin
The design and fabrication of rare earth upconversion nanoparticle (UCNP)-based nanomedical platforms have evoked increasing interest. However, their bio-safety is always the most worrisome problem. Most nanoparticles can accumulate in the internal organs, leading to acute toxicity, a long-term inflammatory response, or even fibrosis and cancer. In contrast, ultrasmall (sub-10 nm) nanoparticles have minimal safety risk because they can escape from macrophages, pass biological barriers, and be easily degraded or excreted from the body...
March 12, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Jaishabanu Ameeramja, Ekambaram Perumal
Fluorosis (fluoride toxicity) seems to be reduced by plant secondary metabolites. Tamarind seed coat extract (TSCE), a mixture of procyanidins and polyphenols, possesses numerous pharmacological activities. Regardless of its beneficial properties, the underlying molecular mechanism against chronic fluorosis in vivo is not known. Hence, the present study is aimed to investigate the efficacy of TSCE against fluoride (F- )-induced pulmonary toxicity in rats. Female Wistar rats were randomly divided into four groups and treated with NaF (300 ppm in drinking water) and TSCE (100 mg/kg/bw by oral intubation) alone and in combination daily for 30 days...
March 5, 2018: Inflammation
Harikrishna Kommidi, Umberto Tosi, Uday B Maachani, Hua Guo, Christopher S Marnell, Benedict Law, Mark M Souweidane, Richard Ting
Histone deacetylase (HDAC) inhibition is becoming an increasingly popular approach to treat cancer, as HDAC overexpression is common in many malignancies. The blood-brain barrier (BBB) prevents systemically delivered drugs from reaching brain at effective concentration, making small-molecule-HDAC inhibition in brain tumors particularly challenging. To circumvent the BBB, novel routes for administering therapeutics are being considered in the clinic, and a need exists for drugs whose deliveries can be directly imaged, so that effective delivery across the BBB can be monitored...
February 8, 2018: ACS Medicinal Chemistry Letters
Sebastien Perbet, Daniel Bourdeaux, Alexandre Lenoire, Claire Biboulet, Bruno Pereira, Malha Sadoune, Benoit Plaud, Jean-Marie Launay, Jean-Etienne Bazin, Valerie Sautou, Alexandre Mebazaa, Pascal Houze, Jean-Michel Constantin, Matthieu Legrand
BACKGROUND: Sevoflurane has anti-inflammatory proprieties and short lasting effects making it of interest for procedural sedation in critically ill patients. We evaluated the pharmacokinetics of sevoflurane and metabolites in severely ill burn patients and controls. The secondary objective was to assess potential kidney injury. METHODS: prospective interventional study in a burn and a surgical intensive care unit 24 mechanically ventilated critically ill patients (12 burns, 12 controls) were included,...
February 15, 2018: Anaesthesia, Critical Care & Pain Medicine
Aline Salgado Dionizio, Carina Guimarães Souza Melo, Isabela Tomazini Sabino-Arias, Talita Mendes Silva Ventura, Aline Lima Leite, Sara Raquel Garcia Souza, Erika Xavier Santos, Alessandro Domingues Heubel, Juliana Gadelha Souza, Juliana Vanessa Colombo Martins Perles, Jacqueline Nelisis Zanoni, Marília Afonso Rabelo Buzalaf
Gastrointestinal symptoms are the first signs of fluoride (F) toxicity. In the present study, the jejunum of rats chronically exposed to F was evaluated by proteomics, as well as by morphological analysis. Wistar rats received water containing 0, 10 or 50 mgF/L during 30 days. HuC/D, neuronal Nitric Oxide (nNOS), Vasoactive Intestinal Peptide (VIP), Calcitonin Gene Related Peptide (CGRP), and Substance P (SP) were detected in the myenteric plexus of the jejunum by immunofluorescence. The density of nNOS-IR neurons was significantly decreased (compared to both control and 10 mgF/L groups), while the VIP-IR varicosities were significantly increased (compared to control) in the group treated with the highest F concentration...
February 16, 2018: Scientific Reports
Nikolay A Ogurtsov, Valery N Bliznyuk, Andrii V Mamykin, Oleksandr L Kukla, Yuri P Piryatinski, Alexander A Pud
We report significant improvements in the structure and electronic properties of a poly(3-alkylthiophene) representative, namely poly(3-methylthiophene) (P3MT), when it is synthesized in the presence of submicron electroactive poly(vinylidene fluoride) (PVDF) particles. The applied template oxidative synthesis leads to the formation of the PVDF/P3MT composite consisting of core-shell particles. The shells are constituted with a monolayer of 20-40 nm nanoparticles of the doped P3MT (P3MT-Cl) precipitated at the surface of the spherical PVDF cores...
February 15, 2018: Physical Chemistry Chemical Physics: PCCP
J A Quadri, S Sarwar, A Sinha, M Kalaivani, A K Dinda, A Bagga, T S Roy, T K Das, A Shariff
The susceptibility of the kidneys to fluoride toxicity can largely be attributed to its anatomy and function. As the filtrate moves along the complex tubular structure of each nephron, it is concentrated in the proximal and distal tubules and collecting duct. It has been frequently observed that the children suffering from renal impairments also have some symptoms of dental and skeletal fluorosis. The findings suggest that fluoride somehow interferes with renal anatomy and physiology, which may lead to renal pathogenesis...
January 1, 2018: Human & Experimental Toxicology
Ji Young Song, Kyoung-Sook Jeong, Kyeong-Sook Choi, Min-Gi Kim, Yeon-Soon Ahn
The extent and severity of the psychological effects following chemical release disasters have not been widely reported. The aim of this study was to examine the prevalence of hydrogen fluoride (HF)-related posttraumatic stress disorder (PTSD) and to identify associated psychological risk factors. On September 2012, an estimated 8 to 12 tons of HF gas, which dissolves in air moisture to form droplets of corrosive hydrofluoric acid, escaped from an industrial complex in Gumi, South Korea. Ten months later, structured questionnaires that included items from the Impacts of Event Scale (revised Korean version) as well as questions about demographic and psychological risk factors related to PTSD were distributed to workers in the affected area...
February 1, 2018: Workplace Health & Safety
Huan Zuo, Liang Chen, Ming Kong, Lipeng Qiu, Peng Lü, Peng Wu, Yanhua Yang, Keping Chen
Accumulation of excess fluoride in the environment poses serious health risks to plants, animals, and humans. This endangers human health, affects organism growth and development, and negatively impacts the food chain, thereby affecting ecological balance. In recent years, numerous studies focused on the molecular mechanisms associated with fluoride toxicity. These studies have demonstrated that fluoride can induce oxidative stress, regulate intracellular redox homeostasis, and lead to mitochondrial damage, endoplasmic reticulum stress and alter gene expression...
February 9, 2018: Life Sciences
Tássia F D Castro, Isadora M Paiva, Aline F S Carvalho, Isadora L Assis, Marcel J Palmieri, Larissa F Andrade-Vieira, Silvana Marcussi, Luis D Solis-Murgas
Spent pot liner (SPL) is a solid waste generated during the primary smelting of aluminum, and its toxicity is attributed to the presence of fluoride, cyanide, and aluminum salts, which can be leached into aquatic ecosystems. Since the effects of this waste on aquatic life forms have not yet been investigated, the objective of our study was to evaluate the toxicity of simulated leachates of SPL on zebrafish (Danio rerio). Animals were exposed to 0 (control), 0.32, 0.64, or 0.95 g L-1 of SPL for 24, 72, and 96 h, and genotoxicity was accessed through micronucleus and comet assays...
February 9, 2018: Environmental Science and Pollution Research International
Wenchao Tang, Yuanyuan Xiao, Guannan Li, Xi Zheng, Yaru Yin, Lingyan Wang, Yong Zhu
Fluorine is an essential element, but excessive fluoride can cause serious effects on the respiratory, digestive, and reproductive systems. Fluorine has been suggested to cause reproductive toxicity in vertebrates, but its potential to reproductively affect invertebrates remains unknown. In the present study, the lepidopteran model insect Bombyx mori was used to assess the reproductive toxicity of NaF. The underlying molecular mechanisms were explored by RNA sequencing, and we investigated the testes transcriptomic profile of B...
February 6, 2018: Ecotoxicology and Environmental Safety
Huan Zuo, Liang Chen, Ming Kong, Yanhua Yang, Peng Lü, Lipeng Qiu, Qiang Wang, Shangshang Ma, Keping Chen
Accumulation of excess fluoride has a destructive effect on the environment, endangering human health, affecting organism growth and development, and leading to damage to the biological chain, thereby affecting ecological environment balance. In recent years, numerous studies focused on the molecular mechanisms associated with fluoride toxicity; however, fluoride-toxicity mechanisms in insect cells remain unclear. This study explored the toxic impact of sodium fluoride (NaF) on Spodoptera frugiperda 9 (Sf9) insect cells...
February 2, 2018: Environmental Pollution
Yi-Ying Zhao, Qiang Chu, Xu-Er Shi, Xiao-Dong Zheng, Xiao-Ting Shen, Yan-Zhen Zhang
To address the controversial issue of the toxicity of dental alloys and silver nanoparticles in medical applications, an in vivo-like LO2 3-D model was constructed within polyvinylidene fluoride hollow fiber materials to mimic the microenvironment of liver tissue. The use of microscopy methods and the measurement of liver-specific functions optimized the model for best cell performances and also proved the superiority of the 3-D LO2 model when compared with the traditional monolayer model. Toxicity tests were conducted using the newly constructed model, finding that four dental castings coated with silver nanoparticles were toxic to human hepatocytes after cell viability assays...
2018: Journal of Zhejiang University. Science. B
Daniel L Turman, Abraham Z Cheloff, Alexis D Corrado, Jacob T Nathanson, Christopher Miller
Fluoride ion channels of the Fluc family selectively export F- ions to rescue unicellular organisms from acute F- toxicity. Crystal structures of bacterial Fluc channels in complex with synthetic monobodies, fibronectin-derived soluble β-sandwich fold proteins, show 2-fold symmetric homodimers with an antiparallel transmembrane topology. Monobodies also block Fluc F- current via a pore blocking mechanism. However, little is known about the energetic contributions of individual monobody residues to the affinity of the monobody-channel complex or whether the structural paratope corresponds to functional reality...
February 2, 2018: Biochemistry
Shweta Sharma, Puneet Parashar, Subhasini Sharma, Kanta Prasad Sharma
Plant species rich in antioxidants (vitamins, flavonoids, lignans, and carotenoids) have been explored for complementary therapy of chronic diseases (cancers, coronary heart disease) and mitigation of pollutant toxicity. This article investigates their ameliorative role on selective hematological and serum biochemical parameters in fluoride-exposed (190 mg/kg body weight) Swiss albino mice pretreated with the antioxidant-rich diet supplements tomato puree (with and without peels), spirulina (cyanobacteria), and lycopene (present in tomato) for 45 days prior to entry into experimental protocol...
January 16, 2018: Journal of Dietary Supplements
Amir Mirzaei, Laleh Yerushalmi, Zhi Chen, Fariborz Haghighat, Jianbo Guo
The presence of antibiotics in water bodies has received increasing attention since they are continuously introduced and detected in the environment and may cause unpredictable environmental hazards and risks. The photocatalytic degradation of sulfamethoxazole (SMX) by ZnO in the presence of fluoride ions (F-ZnO) was evaluated. The effects of operating parameters on the efficiency of SMX removal were investigated by using response surface methodology (RSM). Under the optimum condition, i.e. photocatalyst dosage = 1...
January 11, 2018: Water Research
M M Patil, Bhavana B Lakhkar, Shailaja S Patil
Fluoride was identified to have caries preventive properties and was widely used for fluoridation of water since 1940, especially in developed countries. After this there was sudden increase in the use of fluorides in food items and in oral medicinal products like toothpastes and mouth washes. Inadvertent use of above has lead to increase in fluorosis as a public health problem. In many places high fluorides are naturally present in earth crust leading to high water fluoride content increasing the risk of fluorosis...
January 3, 2018: Indian Journal of Pediatrics
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