keyword
MENU ▼
Read by QxMD icon Read
search

Fluoride toxicity

keyword
https://www.readbyqxmd.com/read/28284958/risk-assessment-of-fluoride-exposure-in-drinking-water-of-tunisia
#1
Wiem Guissouma, Othman Hakami, Abdul Jabbar Al-Rajab, Jamila Tarhouni
The presence of fluoride in drinking water is known to reduce dental cavities among consumers, but an excessive intake of this anion might leads to dental and skeletal fluorosis. This study reports a complete survey of the fluoridated tap water taken from 100 water consumption points in Tunisia. The fluoride concentrations in tap water were between 0 and 2.4 mg L(-1). Risk assessment of Fluoride exposure was assessed depending on the age of consumers using a four-step method: hazard identification, toxicity reference values selection (TRVs), daily exposure assessment, and risk characterization...
March 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28266088/fluoride-or-and-aluminum-induced-toxicity-in-guinea-pig-teeth-with-the-low-expression-of-dentine-phosphoprotein
#2
Tianlong Han, Min Wang, Chunfang Cao, Huacheng Chen, Guanghe Zhang, Liping Wang, Jundong Wang
This study investigated the damage and expression of dentine phosphoprotein (DPP) in guinea pig teeth by the administration of fluoride (F) or/and aluminum (Al). Fifty-two guinea pigs were divided randomly into four groups (control, F, Al, and F+Al). F (150 mg NaF/L) or/and Al (300 mg AlCl3 /L) were added in their drinking water for 90 days. The levels of F ion, dentine sialophosphoprotein (DSPP) gene, and DPP protein in incisor and molar were determined, respectively. The results showed that the concentrations of F ion in F and F+Al groups were increased significantly...
March 7, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28261155/environmental-factors-impacting-bone-relevant-chemokines
#3
Justin T Smith, Andrew D Schneider, Karina M Katchko, Chawon Yun, Erin L Hsu
Chemokines play an important role in normal bone physiology and the pathophysiology of many bone diseases. The recent increased focus on the individual roles of this class of proteins in the context of bone has shown that members of the two major chemokine subfamilies-CC and CXC-support or promote the formation of new bone and the remodeling of existing bone in response to a myriad of stimuli. These chemotactic molecules are crucial in orchestrating appropriate cellular homing, osteoblastogenesis, and osteoclastogenesis during normal bone repair...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28258203/mechanism-of-single-and-double-sided-inhibition-of-dual-topology-fluoride-channels-by-synthetic-monobodies
#4
Daniel L Turman, Randy B Stockbridge
The Fluc family of proteins comprises small, electrodiffusive fluoride channels, which prevent accumulation of toxic F(-) ions in microorganisms. Recent crystal structures have confirmed their unusual architecture, in which a pair of antiparallel subunits convenes to form a dimer with a twofold symmetry axis parallel to the plane of the membrane. These structures have also revealed the interactions between Fluc channels and several different fibronectin domain monobodies that inhibit Fluc-mediated F(-) currents; in all structures, each channel binds to two monobodies symmetrically, one on either side of the membrane...
March 3, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28250714/the-effect-of-core-and-lanthanide-ion-dopants-in-sodium-fluoride-based-nanocrystals-on-phagocytic-activity-of-human-blood-leukocytes
#5
Bartlomiej Sojka, Aurelia Liskova, Miroslava Kuricova, Mateusz Banski, Jan Misiewicz, Maria Dusinska, Mira Horvathova, Silvia Ilavska, Michaela Szabova, Eva Rollerova, Artur Podhorodecki, Jana Tulinska
Sodium fluoride-based β-NaLnF4 nanoparticles (NPs) doped with lanthanide ions are promising materials for application as luminescent markers in bio-imaging. In this work, the effect of NPs doped with yttrium (Y), gadolinium (Gd), europium (Eu), thulium (Tm), ytterbium (Yb) and terbium (Tb) ions on phagocytic activity of monocytes and granulocytes and the respiratory burst was examined. The surface functionalization of <10-nm NPs was performed according to our variation of patent pending ligand exchange method that resulted in meso-2,3-dimercaptosuccinic acid (DMSA) molecules on their surface...
2017: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
https://www.readbyqxmd.com/read/28248532/trace-elements-have-beneficial-as-well-as-detrimental-effects-on-bone-homeostasis
#6
I Zofkova, M Davis, J Blahos
The protective role of nutrition factors such as calcium, vitamin D and vitamin K for the integrity of the skeleton is well understood. In addition, integrity of the skeleton is positively influenced by certain trace elements (e.g. zinc, copper, manganese, magnesium, iron, selenium, boron and fluoride) and negatively by others (lead, cadmium, cobalt). Deficiency or excess of these elements influence bone mass and bone quality in adulthood as well as in childhood and adolescence. However, some protective elements may become toxic under certain conditions, depending on dosage (serum concentration), duration of treatment and interactions among individual elements...
February 28, 2017: Physiological Research
https://www.readbyqxmd.com/read/28242422/toxicological-response-of-sprague-dawley-rats-from-inhalation-exposure-to-perfluorooctane-sulfonyl-fluoride-posf
#7
John L Butenhoff, Geary W Olsen, Sue Chang
Perfluorooctane sulfonyl fluoride (POSF) was a volatile starting material in the production of perfluorooctane sulfonate (PFOS), a stable surfactant that has been extensively studied due to its ubiquitous environmental distribution and slow clearance in humans. Because the inhalation toxicity of POSF on repeated exposure has not been previously reported, the current study evaluated the inhalation toxicity of POSF at 30, 100, and 300ppm (v/v) in rats for up to 13 weeks with a four-week recovery period. The extent of PFOS formation was also measured because POSF hydrolyzed to form PFOS...
February 27, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28223109/fluoride-exposure-abates-pro-inflammatory-response-and-induces-in%C3%A2-vivo-apoptosis-rendering-zebrafish-danio-rerio-susceptible-to-bacterial-infections
#8
Rashmi Singh, Preeti Khatri, Nidhi Srivastava, Shruti Jain, Vani Brahmachari, Asish Mukhopadhyay, Shibnath Mazumder
The present study describes the immunotoxic effect of chronic fluoride exposure on adult zebrafish (Danio rerio). Zebrafish were exposed to fluoride (71.12 mg/L; 1/10 LC50) for 30 d and the expression of selected genes studied. We observed significant elevation in the detoxification pathway gene cyp1a suggesting chronic exposure to non-lethal concentration of fluoride is indeed toxic to fish. Fluoride mediated pro-oxidative stress is implicated with the downregulation in superoxide dismutase 1 and 2 (sod1/2) genes...
February 20, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28196604/addition-of-bioactive-glass-to-glass-ionomer-cements-effect-on-the-physico-chemical-properties-and-biocompatibility
#9
T De Caluwé, C W J Vercruysse, I Ladik, R Convents, H Declercq, L C Martens, R M H Verbeeck
OBJECTIVES: Glass ionomer cements (GICs) are a subject of research because of their inferior mechanical properties, despite their advantages such as fluoride release and direct bonding to bone and teeth. Recent research aims to improve the bioactivity of the GICs and thereby improve mechanical properties on the long term. In this study, two types of bioactive glasses (BAG) (45S5F and CF9) are combined with GICs to evaluate the physico-chemical properties and biocompatibility of the BAG-GIC combinations...
February 10, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28196457/dermal-absorption-of-fumigant-gases-during-hazmat-incident-exposure-scenarios-methyl-bromide-sulfuryl-fluoride-and-chloropicrin
#10
Sharyn Gaskin, Linda Heath, Dino Pisaniello, John W Edwards, Michael Logan, Christina Baxter
Accidental or intentional releases of toxic gases or vapors are the most common occurrence in hazardous material (HAZMAT) incidents that result in human injuries. The most serious hazard from exposure to gases or vapors is via the respiratory system. Dermal uptake, as a secondary route, is still a concern, most acutely for the unprotected public. There is a limited evidence base describing skin absorption of toxic gases and vapors in HAZMAT exposure scenarios, which are relatively brief compared with traditional test periods for skin absorption studies...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28178594/the-effects-of-fluoride-based-fire-fighting-foams-on-soil-microbiota-activity-and-plant-growth-during-natural-attenuation-of-perfluorinated-compounds
#11
Renato Nallin Montagnolli, Paulo Renato Matos Lopes, Jaqueline Matos Cruz, Elis Marina Turini Claro, Gabriela Mercuri Quiterio, Ederio Dino Bidoia
The use of fluoride based foams increases the effectiveness of fire-fighting operations, but they are also accompanied by major drawbacks regarding environmental safety of perfluorinated compounds (PFCs). The main concern with PFCs release is due to their well-known persistence and bioaccumulative potential, as they have been detected in many environmental samples. There is a significant knowledge gap on PFC toxicity to plants, even though such data could be useful towards bioremediation procedures. It is consensus that a realistic assessment of fire-fighting foam toxicity should cover as many test organisms as possible, however, few studies combine the performance of ecotoxicological tests with a detailed study of microbial communities in soil contaminated with firefighting foams...
March 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28144801/a-brief-and-critical-review-on-hydrofluorosis-in-diverse-species-of-domestic-animals-in-india
#12
REVIEW
Shanti Lal Choubisa
India is one of the fluoride-endemic countries where the maximum numbers of ground or drinking water sources are naturally fluoridated. In India, a total of 23, out of 36 states and union territories have drinking water contaminated with fluoride in varying concentration. In the present scenario, especially in rural India, besides the surface waters (perennial ponds, dams, rivers, etc.), bore wells and hand pumps are the principal drinking water sources for domestic animals such as cattle (Bos taurus), water buffaloes (Bubalus bubalis), sheep (Ovis aries), goats (Capra hircus), horses (Equus caballus), donkeys (Equus asinus) and dromedary camels (Camelus dromedarius)...
January 31, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28073323/protective-effect-exerted-by-soil-phosphorus-on-soybean-subjected-to-arsenic-and-fluoride
#13
Carolina Bustingorri, Guillermo Noriega, Raúl S Lavado, Karina Balestrasse
Objetive: Arsenic (As) and fluoride (F) are found in groundwater and soils around the world, causing different problems to crops. Because these elements compete against phosphorus (P) in soils and plants, their relationship is complex. The aim of this work was to study the oxidative stress of soybean plants subjected to different concentrations of As and F, and the effect of P. METHODS: The following 10 treatments were carried out in each of two soils with different P content: three As levels (low 10 mg As kg(-1), medium 50 mg As kg(-1) and high 100 mg As kg(-1)), three F levels (low 160 mg F kg(-1), medium 250 mg F kg(-1) and high 500 mg F kg(-1)) and three As + F levels (same concentrations), and the control treatment (soil with the background As and F concentrations) Lipid peroxidation, chlorophyll, gluthatione contents and antioxidant enzymes activities were determination...
January 10, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28050995/anaemia-in-adolescent-girls-an-intervention-of-diet-editing-and-counselling
#14
Andezhath K Susheela, Rashmi Gupta, Nisith K Mondal
BACKGROUND: Though a major public health problem of nutritional anaemia in schoolchildren is being addressed by iron supplementation and/or fortified food, they continue to be anaemic. We aimed to study the effect of fluoride consumption on haemoglobin levels and whether elimination of fluoride from the diet would correct anaemia in children. METHODS: Two hundred and fifty adolescent girls, 10-17 years of age, from a government senior secondary girls school in East Delhi, participated in the programme...
July 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/28028786/determination-of-fluoride-in-organic-and-non-organic-wines
#15
Soraya Paz, Juan Ramón Jaudenes, Angel José Gutiérrez, Carmen Rubio, Arturo Hardisson, Consuelo Revert
Fluorine is an element of great importance to human health, as it is considered to be an essential element. However, both a deficiency and an excess, it can cause various problems. It is for this reason that values have been established regarding the recommended daily intake (RDI) and acceptable daily intake (ADI). The largest source of incorporation of fluoride is water, but it can be found in other foods and beverages, such as vegetables, tea, and wine. The aim of the study was to establish the fluoride concentration in organic and non-organic wines from different appellations of origin of the Canary Islands and mainland Spain, in order to assess the contribution of fluoride and toxic risk...
December 27, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/28012895/protocatechuic-acid-methyl-ester-ameliorates-fluoride-toxicity-in-a549-cells
#16
Jaishabanu Ameeramja, Ekambaram Perumal
The present study is aimed to determine the potential benefits of protocatechuic acid methyl ester (PCAME) against fluoride (F(-)) induced lung toxicity using A549 cells. The cells were treated with sodium fluoride (NaF) alone and in combination with PCAME for different time points (0-24 h) and evaluated for intracellular reactive oxygen species (ROS) production, F(-) content, oxidative stress markers, apoptosis and mRNA expression of redox signaling and inflammatory genes. The results shown that PCAME alleviates the toxic effects of F(-)via modulating its bioavailability, intracellular calcium level, mitochondrial membrane integrity and redox signaling in A549 cells...
December 22, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28009504/multifunctionalization-of-poly-vinylidene-fluoride-reactive-copolymer-blend-membranes-for-broad-spectrum-applications
#17
Dixit V Bhalani, Anupam Bera, Arvind K Singh Chandel, Sweta B Kumar, Suresh K Jewrajka
Simultaneous immobilization and cross-linking of antifouling/low toxic polymers, e.g., poly(ethylenimine) (PEI), dextran (Dex), agarose (Agr), poly(ethylene glycol) (PEG), PEI-Dex, and PEI-PEG conjugates, and stimuli-responsive copolymers on a porous membrane surface in mild reaction conditions is desirable for the enhancement of hydrophilicity, antifouling character, cytocompatibility, and inducing stimuli-responsive behavior. Grafting to technique is required since the precursors of most of these macromolecules are not amenable to surface-initiated polymerization...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28002795/sodium-fluoride-naf-causes-toxic-effects-on-splenic-development-in-mice
#18
Ping Kuang, Huidan Deng, Hengmin Cui, Lian Chen, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Ling Zhao
At present, very limited studies focus on the toxic effect of sodium fluoride (NaF) on splenic development of human and animals in vivo. This study was firstly designed to evaluate the toxic effects of NaF on the splenic development of mice in vivo by observing histopathological lesions, changes of splenic growth index (GI), T and B cells, immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM) contents, cytokine protein expression levels, and cell cycle and cyclins/cdks protein expression levels using the methods of pathology, flow cytometry (FCM), western blot (WB), and enzyme-linked immunosorbent assay (ELISA)...
December 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27990564/planarian-cholinesterase-in-vitro-characterization-of-an-evolutionarily-ancient-enzyme-to-study-organophosphorus-pesticide-toxicity-and-reactivation
#19
Danielle Hagstrom, Hideto Hirokawa, Limin Zhang, Zoran Radic, Palmer Taylor, Eva-Maria S Collins
The freshwater planarian Dugesia japonica has recently emerged as an animal model for developmental neurotoxicology and found to be sensitive to organophosphorus (OP) pesticides. While previous activity staining of D. japonica, which possess a discrete cholinergic nervous system, has shown acylthiocholine catalysis, it is unknown whether this is accomplished through an acetylcholinesterase (AChE), butyrylcholinesterase (BChE), or a hybrid esterase and how OP exposure affects esterase activity. Here, we show that the majority of D...
December 18, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27990445/voriconazole-induced-periostitis-enthesopathy-in-solid-organ-transplant-patients-case-reports
#20
Monica Sircar, Camille Kotton, David Wojciechowski, Kassem Safa, Hannah Gilligan, Eliot Heher, Winfred Williams, Ravi Thadhani, Nina Tolkoff-Rubin
BACKGROUND: Voriconazole is frequently used to treat fungal infections in solid organ transplant patients. Recently, there have been reports suggesting that prolonged voriconazole therapy may lead to periostitis. AIM: Here we present two cases of voriconazole-induced periostitis in solid organ transplant patients. CASE PRESENTATION: Voriconazole was given to two transplant patients-one with a liver transplant and the second with a heart transplant, to treat their fungal infections...
November 2016: Journal of biosciences and medicines
keyword
keyword
104369
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"