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Fluoride toxicity

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https://www.readbyqxmd.com/read/28073323/protective-effect-exerted-by-soil-phosphorus-on-soybean-subjected-to-arsenic-and-fluoride
#1
Carolina Bustingorri, Guillermo Noriega, Raúl S Lavado, Karina Balestrasse
: Objetive: Arsenic (As) and fluoride (F) are found in groundwater and soils around the world, causing different problems to crops. Because these elements compete against phosphorus (P) in soils and plants, their relationship is complex. The aim of this work was to study the oxidative stress of soybean plants subjected to different concentrations of As and F, and the effect of P. METHODS: The following 10 treatments were carried out in each of two soils with different P content: three As levels (low 10 mg As kg(-1), medium 50 mg As kg(-1) and high 100 mg As kg(-1)), three F levels (low 160 mg F kg(-1), medium 250 mg F kg(-1) and high 500 mg F kg(-1)) and three As + F levels (same concentrations), and the control treatment (soil with the background As and F concentrations) Lipid peroxidation, chlorophyll, gluthatione contents and antioxidant enzymes activities were determination...
January 10, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28050995/anaemia-in-adolescent-girls-an-intervention-of-diet-editing-and-counselling
#2
Andezhath K Susheela, Rashmi Gupta, Nisith K Mondal
BACKGROUND: Though a major public health problem of nutritional anaemia in schoolchildren is being addressed by iron supplementation and/or fortified food, they continue to be anaemic. We aimed to study the effect of fluoride consumption on haemoglobin levels and whether elimination of fluoride from the diet would correct anaemia in children. METHODS: Two hundred and fifty adolescent girls, 10-17 years of age, from a government senior secondary girls school in East Delhi, participated in the programme...
July 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/28028786/determination-of-fluoride-in-organic-and-non-organic-wines
#3
Soraya Paz, Juan Ramón Jaudenes, Angel José Gutiérrez, Carmen Rubio, Arturo Hardisson, Consuelo Revert
Fluorine is an element of great importance to human health, as it is considered to be an essential element. However, both a deficiency and an excess, it can cause various problems. It is for this reason that values have been established regarding the recommended daily intake (RDI) and acceptable daily intake (ADI). The largest source of incorporation of fluoride is water, but it can be found in other foods and beverages, such as vegetables, tea, and wine. The aim of the study was to establish the fluoride concentration in organic and non-organic wines from different appellations of origin of the Canary Islands and mainland Spain, in order to assess the contribution of fluoride and toxic risk...
December 27, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/28012895/protocatechuic-acid-methyl-ester-ameliorates-fluoride-toxicity-in-a549-cells
#4
Jaishabanu Ameeramja, Ekambaram Perumal
The present study is aimed to determine the potential benefits of protocatechuic acid methyl ester (PCAME) against fluoride (F(-)) induced lung toxicity using A549 cells. The cells were treated with sodium fluoride (NaF) alone and in combination with PCAME for different time points (0-24 h) and evaluated for intracellular reactive oxygen species (ROS) production, F(-) content, oxidative stress markers, apoptosis and mRNA expression of redox signaling and inflammatory genes. The results shown that PCAME alleviates the toxic effects of F(-)via modulating its bioavailability, intracellular calcium level, mitochondrial membrane integrity and redox signaling in A549 cells...
December 22, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28009504/multifunctionalization-of-poly-vinylidene-fluoride-reactive-copolymer-blend-membranes-for-broad-spectrum-applications
#5
Dixit V Bhalani, Anupam Bera, Arvind K Singh Chandel, Sweta B Kumar, Suresh K Jewrajka
Simultaneous immobilization and cross-linking of antifouling/low toxic polymers, e.g., poly(ethylenimine) (PEI), dextran (Dex), agarose (Agr), poly(ethylene glycol) (PEG), PEI-Dex, and PEI-PEG conjugates, and stimuli-responsive copolymers on a porous membrane surface in mild reaction conditions is desirable for the enhancement of hydrophilicity, antifouling character, cytocompatibility, and inducing stimuli-responsive behavior. Grafting to technique is required since the precursors of most of these macromolecules are not amenable to surface-initiated polymerization...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28002795/sodium-fluoride-naf-causes-toxic-effects-on-splenic-development-in-mice
#6
Ping Kuang, Huidan Deng, Hengmin Cui, Lian Chen, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Ling Zhao
At present, very limited studies focus on the toxic effect of sodium fluoride (NaF) on splenic development of human and animals in vivo. This study was firstly designed to evaluate the toxic effects of NaF on the splenic development of mice in vivo by observing histopathological lesions, changes of splenic growth index (GI), T and B cells, immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM) contents, cytokine protein expression levels, and cell cycle and cyclins/cdks protein expression levels using the methods of pathology, flow cytometry (FCM), western blot (WB), and enzyme-linked immunosorbent assay (ELISA)...
December 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27990564/planarian-cholinesterase-in-vitro-characterization-of-an-evolutionarily-ancient-enzyme-to-study-organophosphorus-pesticide-toxicity-and-reactivation
#7
Danielle Hagstrom, Hideto Hirokawa, Limin Zhang, Zoran Radic, Palmer Taylor, Eva-Maria S Collins
The freshwater planarian Dugesia japonica has recently emerged as an animal model for developmental neurotoxicology and found to be sensitive to organophosphorus (OP) pesticides. While previous activity staining of D. japonica, which possess a discrete cholinergic nervous system, has shown acylthiocholine catalysis, it is unknown whether this is accomplished through an acetylcholinesterase (AChE), butyrylcholinesterase (BChE), or a hybrid esterase and how OP exposure affects esterase activity. Here, we show that the majority of D...
December 18, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27990445/voriconazole-induced-periostitis-enthesopathy-in-solid-organ-transplant-patients-case-reports
#8
Monica Sircar, Camille Kotton, David Wojciechowski, Kassem Safa, Hannah Gilligan, Eliot Heher, Winfred Williams, Ravi Thadhani, Nina Tolkoff-Rubin
BACKGROUND: Voriconazole is frequently used to treat fungal infections in solid organ transplant patients. Recently, there have been reports suggesting that prolonged voriconazole therapy may lead to periostitis. AIM: Here we present two cases of voriconazole-induced periostitis in solid organ transplant patients. CASE PRESENTATION: Voriconazole was given to two transplant patients-one with a liver transplant and the second with a heart transplant, to treat their fungal infections...
November 2016: Journal of biosciences and medicines
https://www.readbyqxmd.com/read/27917370/multiple-myeloma-like-spinal-mri-findings-in-skeletal-fluorosis-an-unusual-presentation-of-fluoride-toxicity-in-human
#9
Javed Ahsan Quadri, Mohd Meraj Alam, Saba Sarwar, Ashraf Ghanai, A Shariff, Taposh K Das
Endemic fluorosis is a worldwide environmental problem due to excessive fluoride, commonly due to increased drinking water fluoride levels but sometimes due to other sources such as food with high fluoride content. In India, 21 of the 35 states are known to have health problems associated with fluoride toxicity. The present report is a case of a 50-year-old female who was seen with progressive spinal complications and a MRI of the spine suggestive of multiple myeloma. The MRI of the lumbosacral spine showed a diffuse and heterogeneous marrow signal of the lower dorsal and lumbosacral vertebrae...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27876966/evaluation-of-sodium-fluoride-toxicity-in-schistosoma-infected-snails-assessment-of-antioxidants-antiapoptotic-hypoprotein-and-hypocholesterol-activities
#10
Khaled M M Koriem, Radziyah B Shamsuri, Asliza M Ubaidillah
The snails' tissues represents an intermediate or secondary host for Schistosoma sporocysts where, germ cells within the secondary sporocyst begin to divide to produce thousands of cercariae capable of infecting humans. The aim of the study was to evaluate the toxicity of sodium fluoride in Schistosoma snails' tissue homogenates. A total number of 264 different Schistosoma snails were collected from eight drainage water resources and divided into control uninfected and infected snails; where infected snails divided into four group; the first group without any treatment while second, third and fourth groups immersed in 25, 50 and 100 mg sodium fluoride/L during the period of 4 weeks then the snails' hemolymph and tissue homogenates were prepared to evaluate the snail' tissue antioxidants, protein content, lipid profile and apoptosis...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27871895/protective-effect-of-lycopene-on-fluoride-induced-ameloblasts-apoptosis-and-dental-fluorosis-through-oxidative-stress-mediated-caspase-pathways
#11
Weishan Li, Binghua Jiang, Xianglin Cao, Yongjiang Xie, Ting Huang
Fluoride is an environmental toxicant and induces dental fluorosis and oxidative stress. Lycopene (LYC) is an effective antioxidant that is reported to attenuate fluoride toxicity. To determine the effects of LYC on sodium fluoride (NaF) -induced teeth and ameloblasts toxicity, rats were treated with NaF (10 mg/kg) and/or LYC (10 mg/kg) by orally administration for 5 weeks; ameloblasts were treated with NaF (5 mM) and/or LYC (2 μM) for 6 h. We found that the concentrations of fluoride, malondialdehyde (MDA) and reactive oxygen species (ROS), gene expressions and activities of Caspase-9 and Caspase-3, and the gene expressions of Bax were significantly decreased, while the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPX), the gene expression of Bcl-2 were significantly increased in the LYC + NaF-treated rats group; concentrations of MDA and ROS, gene expressions and activities of Caspase-9 and Caspase-3, and the gene expression of Bax, and ameloblasts apoptosis rate were significantly decreased, while the activities of SOD and GPX, the gene expression of Bcl-2 were significantly increased in the LYC + NaF-treated ameloblasts group...
January 5, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27862939/cell-cycle-arrest-and-gene-expression-profiling-of-testis-in-mice-exposed-to-fluoride
#12
Kai Su, Zilong Sun, Ruiyan Niu, Ying Lei, Jing Cheng, Jundong Wang
Exposure to fluoride results in low reproductive capacity; however, the mechanism underlying the impact of fluoride on male productive system still remains obscure. To assess the potential toxicity in testis of mice administrated with fluoride, global genome microarray and real-time PCR were performed to detect and identify the altered transcriptions. The results revealed that 763 differentially expressed genes were identified, including 330 up-regulated and 433 down-regulated genes, which were involved in spermatogenesis, apoptosis, DNA damage, DNA replication, and cell differentiation...
November 14, 2016: Environmental Toxicology
https://www.readbyqxmd.com/read/27858711/cholinesterase-inhibitor-therapy-in-alzheimer-s-disease-the-limits-and-tolerability-of-irreversible-cns-selective-acetylcholinesterase-inhibition-in-primates
#13
Donald E Moss, Ruth G Perez, Haruo Kobayashi
Irreversible acetylcholinesterase (AChE) inhibition accumulates to high levels in the central nervous system (CNS) because AChE turnover in the brain is much slower than in peripheral tissues. As expected from this CNS selectivity, the irreversible AChE inhibitor methanesulfonyl fluoride (MSF) produces significant cognitive improvement in Alzheimer's disease patients without the gastrointestinal toxicity that plagues other AChE inhibitors. However, without dose-limiting gastrointestinal toxicity, one shortcoming of the prior human studies of MSF is that the upper limits of CNS AChE inhibition that might be tolerated could not be tested...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27854046/fluoride-exposure-aggravates-the-testicular-damage-and-sperm-quality-in-diabetic-mice-protective-role-of-ginseng-and-banaba
#14
Saumya Sm, P Mahaboob Basha
Fluoride toxicity is known to pose infertility in fluoride-intoxicated animals as well as in people residing in fluoride endemic zones. The present study addresses the degree of impairments caused due to co-exposure of high fluoride toxicity in diabetic mice. Swiss mice, Mus musculus, were subjected to fluoride toxicity by providing fluoride-supplemented drinking water (600 ppm NaF) for a period of 30 days after the confirmation of streptozotocin-induced diabetes(STZ, 50 mg/kgbw). Consequently, aggravated hyperglycemia and tissue fluoride accumulation were witnessed in fluoride-intoxicated diabetic mice; later, these toxicated mice were treated with ginseng extract (GE) and banaba leaf extract, (BLE) at dose of 150 mg/kgbw/day alone and in combination for 15 and 30-day duration to check the efficacy of phytoextracts in reversing the toxicity...
November 16, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27843247/comparative-evaluation-of-remineralizing-potential-of-three-pediatric-dentifrices
#15
REVIEW
Ashna Kapoor, K R Indushekar, Bhavna G Saraf, Neha Sheoran, Divesh Sardana
INTRODUCTION: Dentifrices are available in different formulations and more commonly a single dentifrice is used by whole family; be it an adult or child. However, concerns over high fluoride in pediatric formulations coupled with inability of the children to spit have led to recommendations to minimize fluoride ingestion during toothbrushing by using a small amount of toothpaste by children and incorporating minimal quantity of fluoride in the toothpastes. Literature is scarce on the remineralization potential of popularly known Indian pediatric dentifrices; hence, pediatric dentifrices containing lesser concentration of fluoride have been marketed relatively recently for the benefit of children without posing a threat of chronic fluoride toxicity at the same time...
July 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27814553/effect-of-fluoride-on-the-cell-viability-cell-organelle-potential-and%C3%A2-photosynthetic-capacity-of-freshwater-and-soil-algae
#16
Yooeun Chae, Dokyung Kim, Youn-Joo An
Although fluoride occurs naturally in the environment, excessive amounts of fluoride in freshwater and terrestrial ecosystems can be harmful. We evaluated the toxicity of fluoride compounds on the growth, viability, and photosynthetic capacity of freshwater (Chlamydomonas reinhardtii and Pseudokirchneriella subcapitata) and terrestrial (Chlorococcum infusionum) algae. To measure algal growth inhibition, a flow cytometric method was adopted (i.e., cell size, granularity, and auto-fluorescence measurements), and algal yield was calculated to assess cell viability...
December 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27810507/effect-of-fe-ii-ce-iii-dosage-ratio-on-the-structure-and-anion-adsorptive-removal-of-hydrothermally-precipitated-composites-insights-from-exafs-xanes-xrd-and-ftir
#17
Natalia Chubar, Vasyl Gerda, Dipanjan Banerjee, Ganna Yablokova
In this work, we present material chemistry in the hydrothermal synthesis of new complex structure materials based on various dosage ratios of Fe and Ce (1:0, 2:1, 1:1, 1:2, 0:1), characterize them by the relevant methods that allow characterization of both crystalline and amorphous phases and correlate their structure/surface properties with the adsorptive performance of the five toxic anions. The applied synthesis conditions resulted in the formation of different compounds of Fe and Ce components. The Fe-component was dominated by various phases of Fe hydrous oxides, whereas the Ce-component was composed of various phases of Ce carbonates...
February 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27787813/the-influence-of-fluorine-on-the-disturbances-of-homeostasis-in-the-central-nervous-system
#18
REVIEW
K Dec, A Łukomska, D Maciejewska, K Jakubczyk, I Baranowska-Bosiacka, D Chlubek, A Wąsik, I Gutowska
Fluorides occur naturally in the environment, the daily exposure of human organism to fluorine mainly depends on the intake of this element with drinking water and it is connected with the geographical region. In some countries, we can observe the endemic fluorosis-the damage of hard and soft tissues caused by the excessive intake of fluorine. Recent studies showed that fluorine is toxic to the central nervous system (CNS). There are several known mechanisms which lead to structural brain damage caused by the excessive intake of fluorine...
October 27, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27766093/isolation-and-characterization-of-gut-bacterial-proteases-involved-in-inducing-pathogenicity-of-bacillus-thuringiensis-toxin-in-cotton-bollworm-helicoverpa-armigera
#19
Visweshwar Regode, Sreeramulu Kuruba, Akbar S Mohammad, Hari C Sharma
Bacillus thuringiensis toxin proteins are deployed in transgenic plants for pest management. The present studies were aimed at characterization of gut bacterial proteases involved in activation of inactive Cry1Ac protoxin (pro-Cry1Ac) to active toxin in Helicoverpa armigera. Bacterial strains were isolated from H. armigera midgut and screened for their proteolytic activation toward pro-Cry1Ac. Among 12 gut bacterial isolates seven isolates showed proteolytic activity, and proteases from three isolates (IVS1, IVS2, and IVS3) were found to be involved in the proteolytic conversion of pro-Cry1Ac into active toxin...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27754647/ammonium-fluoride-mediated-synthesis-of-anhydrous-metal-fluoride-mesoporous-carbon-nanocomposites-for-high-performance-lithium-ion-battery-cathodes
#20
Jinyoung Chun, Changshin Jo, Sunhye Sahgong, Min Gyu Kim, Eunho Lim, Dong Hyeon Kim, Jongkook Hwang, Eunae Kang, Keun Ah Ryu, Yoon Seok Jung, Youngsik Kim, Jinwoo Lee
Metal fluorides (MFx) are one of the most attractive cathode candidates for Li ion batteries (LIBs) due to their high conversion potentials with large capacities. However, only a limited number of synthetic methods, generally involving highly toxic or inaccessible reagents, currently exist, which has made it difficult to produce well-designed nanostructures suitable for cathodes; consequently, harnessing their potential cathodic properties has been a challenge. Herein, we report a new bottom-up synthetic method utilizing ammonium fluoride (NH4F) for the preparation of anhydrous MFx (CuF2, FeF3, and CoF2)/mesoporous carbon (MSU-F-C) nanocomposites, whereby a series of metal precursor nanoparticles preconfined in mesoporous carbon were readily converted to anhydrous MFx through simple heat treatment with NH4F under solventless conditions...
December 28, 2016: ACS Applied Materials & Interfaces
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