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pancreas ductal cancer biopsy

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https://www.readbyqxmd.com/read/28750659/alliance-for-clinical-trials-in-oncology-alliance-trial-a021501-preoperative-extended-chemotherapy-vs-chemotherapy-plus-hypofractionated-radiation-therapy-for-borderline-resectable-adenocarcinoma-of-the-head-of-the-pancreas
#1
Matthew H G Katz, Fang-Shu Ou, Joseph M Herman, Syed A Ahmad, Brian Wolpin, Robert Marsh, Spencer Behr, Qian Shi, Michael Chuong, Lawrence H Schwartz, Wendy Frankel, Eric Collisson, Eugene J Koay, JoLeen M Hubbard, James L Leenstra, Jeffrey Meyerhardt, Eileen O'Reilly
BACKGROUND: Borderline resectable pancreatic cancers infiltrate into adjacent vascular structures to an extent that makes an R0 resection unlikely when pancreatectomy is performed de novo. In a pilot study, Alliance for Clinical Trials in Oncology Trial A021101, the median survival of patients who received chemotherapy and radiation prior to anticipated pancreatectomy was 22 months, and 64% of operations achieved an R0 resection. However, the individual contributions of preoperative chemotherapy and radiation therapy to therapeutic outcome remain poorly defined...
July 27, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28720843/clinical-study-of-genomic-drivers-in-pancreatic-ductal-adenocarcinoma
#2
Michael T Barrett, Ray Deiotte, Elizabeth Lenkiewicz, Smriti Malasi, Tara Holley, Lisa Evers, Richard G Posner, Timothy Jones, Haiyong Han, Mark Sausen, Victor E Velculescu, Jeffrey Drebin, Peter O'Dwyer, Gayle Jameson, Ramesh K Ramanathan, Daniel D Von Hoff
BACKGROUND: Pancreatic ductal adenocarcinoma (PDA) is a lethal cancer with complex genomes and dense fibrotic stroma. This study was designed to identify clinically relevant somatic aberrations in pancreatic cancer genomes of patients with primary and metastatic disease enrolled and treated in two clinical trials. METHODS: Tumour nuclei were flow sorted prior to whole genome copy number variant (CNV) analysis. Targeted or whole exome sequencing was performed on most samples...
August 8, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28693147/pancreatic-intraductal-tubulopapillary-neoplasm-with-associated-invasive-cancer-successfully-treated-by-total-pancreatectomy-a-case-report
#3
Yuji Fujimoto, Yoshito Tomimaru, Hiromi Tamura, Kozo Noguchi, Hirotsugu Nagase, Atsushi Hamabe, Masashi Hirota, Kazuteru Oshima, Tsukasa Tanida, Tomono Kawase, Shunji Morita, Hiroshi Imamura, Takashi Iwazawa, Kenzo Akagi, Masashi Yamamoto, Tsutomu Nishida, Shiro Adachi, Keizo Dono
A 74-year-old male was admitted to Departments of Surgery, Toyonaka Municipal Hospital (Osaka, Japan) for treatment of a pancreatic tumor. Contrast enhanced computed tomography (CT) revealed a mass with small cystic lesions in the pancreatic head and body. Fluorodeoxyglucose-positron emission tomography/CT revealed an abnormal uptake of fluorodeoxyglucose, corresponding to the mass lesions. Upper gastrointestinal endoscopy revealed rough mucosa near the opening of the accessory pancreatic duct, and the mucosa biopsy exhibited adenocarcinoma with no mucin observed...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28373919/complete-response-after-treatment-with-neoadjuvant-chemoradiation-with-prolonged-chemotherapy-for-locally-advanced-unresectable-adenocarcinoma-of-the-pancreas
#4
Tiffany A Pompa, William F Morano, Chetan Jeurkar, Hui Li, Suganthi Soundararajan, Jaganmohan Poli, Wilbur B Bowne, Michael Styler
Surgery is the only chance for cure in pancreatic ductal adenocarcinoma. In unresectable, locally advanced pancreatic cancer (LAPC), the National Comprehensive Cancer Network (NCCN) suggests chemotherapy and consideration for radiation in cases of unresectable LAPC. Here we present a rare case of unresectable LAPC with a complete histopathological response after chemoradiation followed by surgical resection. A 54-year-old female presented to our clinic in December 2013 with complaints of abdominal pain and 30-pound weight loss...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28133200/-a-case-of-synchronous-double-cancers-of-the-liver-and-pancreas-treated-using-pancreaticoduodenectomy-and-liver-resection
#5
Yasuji Hashimoto, Yo Sasaki, Shigekazu Yokoyama, Yoko Yamamoto, Shintaro Michishita, Hajime Hirose, Kenichi Nagai, Tomohiro Maniwa, Yoshihito Ide, Jin Matsuyama, Masashi Takeda, Takashi Morimoto, Yukio Fukushima, Ken Kodama
A 50-year-old woman had a 12mm liver tumor at segment 4 and was diagnosed with hemangioma. Two years later, the liver tumor had grown to 27mm in diameter, and a new pancreatic tumor was detected using CT examination. The pancreatic tumor was suspected of being pancreatic carcinoma, based on the results of endoscopic-ultrasound-guided fine-needlebiopsy( EUS-FNA)of the pancreas. The liver tumor was diagnosed as adenocarcinoma using liver biopsy. Because of its slow growth and the solitary liver tumor, synchronous pancreatic cancer and intrahepatic cancer were suspected...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28125707/digital-pcr-improves-mutation-analysis-in-pancreas-fine-needle-aspiration-biopsy-specimens
#6
Shonan Sho, Colin M Court, Stephen Kim, David R Braxton, Shuang Hou, V Raman Muthusamy, Rabindra R Watson, Alireza Sedarat, Hsian-Rong Tseng, James S Tomlinson
Applications of precision oncology strategies rely on accurate tumor genotyping from clinically available specimens. Fine needle aspirations (FNA) are frequently obtained in cancer management and often represent the only source of tumor tissues for patients with metastatic or locally advanced diseases. However, FNAs obtained from pancreas ductal adenocarcinoma (PDAC) are often limited in cellularity and/or tumor cell purity, precluding accurate tumor genotyping in many cases. Digital PCR (dPCR) is a technology with exceptional sensitivity and low DNA template requirement, characteristics that are necessary for analyzing PDAC FNA samples...
2017: PloS One
https://www.readbyqxmd.com/read/28121262/detection-of-mutant-kras-and-tp53-dna-in-circulating-exosomes-from-healthy-individuals-and-patients-with-pancreatic-cancer
#7
Sujuan Yang, Sara P Y Che, Paul Kurywchak, Jena L Tavormina, Liv B Gansmo, Pedro Correa de Sampaio, Michael Tachezy, Maximilian Bockhorn, Florian Gebauer, Amanda R Haltom, Sonia A Melo, Valerie S LeBleu, Raghu Kalluri
Pancreatic cancer presents with a dismal mortality rate and is in urgent need of methods for early detection with potential for timely intervention. All living cells, including cancer cells, generate exosomes. We previously discovered double stranded genomic DNA in exosomes derived from the circulation of pancreatic cancer patients, which enabled the detection of prevalent mutations associated with the disease. Here, we report a proof-of-concept study that demonstrates the potential clinical utility of circulating exosomal DNA for identification of KRAS(G)(12)(D) and TP53(R)(273)(H) mutations in patients with pancreas-associated pathologies, including pancreatic ductal adenocarcinoma (PDAC), chronic pancreatitis (CP) and intraductal papillary mucinous neoplasm (IPMN), and in healthy human subjects...
March 4, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28114893/a-case-of-multicentric-pancreatic-mixed-acinar-ductal-carcinoma-diagnosed-by-a-yogurt-like-cell-clump-flowing-from-the-papilla-of-vater
#8
Yoshihiro Kishida, Hiroyuki Matsubayashi, Keiko Sasaki, Shinsaku Honda, Sunao Uemura, Katsuhiko Uesaka, Akiko Todaka, Hiroyuki Ono
BACKGROUND: Histological confirmation is needed when the pancreatic lesions is uncertain for neoplastic or nonneoplastic. Current case with multicentric pancreatic carcinomas showing indefinite clinical images was successfully diagnosed by a biopsy of a novel object expelled from the papilla. CASE PRESENTATION: A 71-year-old male was referred because of elevated serum pancreatic enzymes. Computed tomography revealed an unclear low-density area in the pancreatic body without evidence of tumor and mild dilation of the upstream main pancreatic duct (MPD)...
January 23, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/26805359/-three-resected-cases-of-metachronous-pancreatic-cancer-successfully-treated-with-repeated-pancreatectomy
#9
Kozo Noguchi, Yoshito Tomimaru, Hidetoshi Eguchi, Hisataka Ogawa, Daisaku Yamada, Akira Tomokuni, Takehiro Noda, Tadafumi Asaoka, Hiroshi Wada, Koichi Kawamoto, Kunihito Goto, Shigeru Marubashi, Hiroaki Nagano, Masaki Mori, Yuichiro Doki
Repeated pancreatectomy for metachronous pancreatic cancer has rarely been reported. We report 3 cases with metachronous pancreatic ductal carcinoma that developed after pancreatectomy for the first pancreatic cancer. They were successfully resected by removal of the remnant pancreas. In all 3 cases, the cancers in the remnant pancreas were treated with repeated pancreatectomy. The histological margin of the first pancreatic resection was cancer-free in all the cases. Furthermore, the second cancer tissue contained carcinoma lesions in situ adjacent to invasive ductal carcinoma...
November 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/26504042/gene-expression-of-col11a1-is-a-marker-not-only-for-pancreas-carcinoma-but-also-for-adenocarcinoma-of-the-papilla-of-vater-discriminating-between-carcinoma-and-chronic-pancreatitis
#10
COMPARATIVE STUDY
Robert Kleinert, Klaus Prenzel, Nikolas Stoecklein, Hakan Alakus, Elfriede Bollschweiler, Arnulf Hölscher, Ute Warnecke-Eberz
AIM: For tumors of the periampullary region clinical differentiation between primary and tumor-associated pancreatitis might be difficult. Early diagnosis of these malignancies is essential, as they present with early invasion of surrounding tissue thus limiting therapeutic options. Using molecular markers, the preoperative diagnosis (EUS-guided needle biopsy, brush biopsy pancreatic duct) could be optimized and surgical therapy potentially adapted. Alpha1 (XI) collagen Col11A1 is essential for the extracellular matrix and normal skeletal development and has been associated with carcinogenesis...
November 2015: Anticancer Research
https://www.readbyqxmd.com/read/26463029/-value-of-intraoperative-fine-needle-aspiration-cytology-in-the-diagnosis-of-pancreatic-cancer
#11
Xu Che, Zhihui Zhang, Yantao Tian, Jianwei Zhang, Yingtai Chen, Chengfeng Wang
OBJECTIVE: To evaluate the value of intraoperative fine needle aspiration cytology (IFNAC) examination in the diagnosis of pancreatic lesions. METHODS: The clinicopathological data of 491 patients with pancreatic lesions treated in our hospital from May 1998 to June 2013 were retrospectively analyzed. Their clinical features, IFNAC findings, pathological results after IFNAC examination and related complications were summarized. The factors affecting the aspiration biopsy accuracy were analyzed using logistic regression and multi factor analysis...
May 2015: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/26087782/synchronous-pancreatic-ductal-adenocarcinomas-diagnosed-by-endoscopic-ultrasound-guided-fine-needle-biopsy
#12
Hyeon Jeong Goong, Jong Ho Moon, Hyun Jong Choi, Yun Nah Lee, Moon Han Choi, Hee Kyung Kim, Tae Hoon Lee, Sang-Woo Cha
Cases of pancreatic ductal adenocarcinoma with multiple masses accompanying underlying pancreatic diseases, such as intraductal papillary mucinous neoplasm, have been reported. However, synchronous invasion without underlying pancreatic disease is very rare. A 61-year-old female with abdominal discomfort and jaundice was admitted to our hospital. Abdominal computed tomography (CT) revealed cancer of the pancreatic head with direct invasion of the duodenal loop and common bile duct. However, positron emission tomography-CT showed an increased standardized uptake value (SUV) in the pancreatic head and tail...
September 23, 2015: Gut and Liver
https://www.readbyqxmd.com/read/26034375/metastasized-pancreatic-carcinoma-with-neoadjuvant-folfirinox-therapy-and-r0-resection
#13
Sophie Schneitler, Patric Kröpil, Jasmin Riemer, Gerald Antoch, Wolfram Trudo Knoefel, Dieter Häussinger, Dirk Graf
Patients with metastasized carcinoma of the pancreas have a very poor prognosis, and long-term survival cannot be expected. This case report describes two patients with an initial diagnosis of metastatic pancreatic cancer, both with hepatic metastases and one with an additional peritoneal carcinomatosis. Initially, both patients were treated intravenously with the FOLFIRINOX chemotherapy regimen, consisting of 5-FU, folinic acid, irinotecan and oxaliplatin. Surprisingly, the FOLFIRINOX treatment resulted in complete resolution of the hepatic metastases in both patients, with no lesions detectable by computed tomography scan...
May 28, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25938853/early-detection-of-sporadic-pancreatic-cancer-strategic-map-for-innovation-a-white-paper
#14
Barbara J Kenner, Suresh T Chari, Deborah F Cleeter, Vay Liang W Go
Innovation leading to significant advances in research and subsequent translation to clinical practice is urgently necessary in early detection of sporadic pancreatic cancer. Addressing this need, the Early Detection of Sporadic Pancreatic Cancer Summit Conference was conducted by Kenner Family Research Fund in conjunction with the 2014 American Pancreatic Association and Japan Pancreas Society Meeting. International interdisciplinary scientific representatives engaged in strategic facilitated conversations based on distinct areas of inquiry: Case for Early Detection: Definitions, Detection, Survival, and Challenges; Biomarkers for Early Detection; Imaging; and Collaborative Studies...
July 2015: Pancreas
https://www.readbyqxmd.com/read/25931254/early-detection-of-sporadic-pancreatic-cancer-summative-review
#15
REVIEW
Suresh T Chari, Kimberly Kelly, Michael A Hollingsworth, Sarah P Thayer, David A Ahlquist, Dana K Andersen, Surinder K Batra, Teresa A Brentnall, Marcia Canto, Deborah F Cleeter, Matthew A Firpo, Sanjiv Sam Gambhir, Vay Liang W Go, O Joe Hines, Barbara J Kenner, David S Klimstra, Markus M Lerch, Michael J Levy, Anirban Maitra, Sean J Mulvihill, Gloria M Petersen, Andrew D Rhim, Diane M Simeone, Sudhir Srivastava, Masao Tanaka, Aaron I Vinik, David Wong
Pancreatic cancer (PC) is estimated to become the second leading cause of cancer death in the United States by 2020. Early detection is the key to improving survival in PC. Addressing this urgent need, the Kenner Family Research Fund conducted the inaugural Early Detection of Sporadic Pancreatic Cancer Summit Conference in 2014 in conjunction with the 45th Anniversary Meeting of the American Pancreatic Association and Japan Pancreas Society. This seminal convening of international representatives from science, practice, and clinical research was designed to facilitate challenging interdisciplinary conversations to generate innovative ideas leading to the creation of a defined collaborative strategic pathway for the future of the field...
July 2015: Pancreas
https://www.readbyqxmd.com/read/25896973/precision-medicine-for-advanced-pancreas-cancer-the-individualized-molecular-pancreatic-cancer-therapy-impact-trial
#16
RANDOMIZED CONTROLLED TRIAL
Lorraine A Chantrill, Adnan M Nagrial, Clare Watson, Amber L Johns, Mona Martyn-Smith, Skye Simpson, Scott Mead, Marc D Jones, Jaswinder S Samra, Anthony J Gill, Nicole Watson, Venessa T Chin, Jeremy L Humphris, Angela Chou, Belinda Brown, Adrienne Morey, Marina Pajic, Sean M Grimmond, David K Chang, David Thomas, Lucille Sebastian, Katrin Sjoquist, Sonia Yip, Nick Pavlakis, Ray Asghari, Sandra Harvey, Peter Grimison, John Simes, Andrew V Biankin
PURPOSE: Personalized medicine strategies using genomic profiling are particularly pertinent for pancreas cancer. The Individualized Molecular Pancreatic Cancer Therapy (IMPaCT) trial was initially designed to exploit results from genome sequencing of pancreatic cancer under the auspices of the International Cancer Genome Consortium (ICGC) in Australia. Sequencing revealed small subsets of patients with aberrations in their tumor genome that could be targeted with currently available therapies...
May 1, 2015: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/25759555/pancreatic-intraductal-papillary-mucinous-neoplasm-in-a-patient-with-lynch-syndrome
#17
Meghan R Flanagan, Arjun Jayaraj, Wei Xiong, Matthew M Yeh, Wendy H Raskind, Venu G Pillarisetty
Intraductal papillary mucinous neoplasm (IPMN) is a mucin-producing epithelial neoplasm that carries a risk of progression to invasive pancreatic ductal adenocarcinoma. Lynch syndrome is an autosomal dominant condition caused by germline mutations in mismatch repair genes such as MSH2 that lead to microsatellite instability and increased risk of tumor formation. Although families with Lynch syndrome have an increased risk of pancreatic cancer, a clear connection between Lynch syndrome and IPMN has not been drawn...
March 7, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25557080/organoid-models-of-human-and-mouse-ductal-pancreatic-cancer
#18
Sylvia F Boj, Chang-Il Hwang, Lindsey A Baker, Iok In Christine Chio, Dannielle D Engle, Vincenzo Corbo, Myrthe Jager, Mariano Ponz-Sarvise, Hervé Tiriac, Mona S Spector, Ana Gracanin, Tobiloba Oni, Kenneth H Yu, Ruben van Boxtel, Meritxell Huch, Keith D Rivera, John P Wilson, Michael E Feigin, Daniel Öhlund, Abram Handly-Santana, Christine M Ardito-Abraham, Michael Ludwig, Ela Elyada, Brinda Alagesan, Giulia Biffi, Georgi N Yordanov, Bethany Delcuze, Brianna Creighton, Kevin Wright, Youngkyu Park, Folkert H M Morsink, I Quintus Molenaar, Inne H Borel Rinkes, Edwin Cuppen, Yuan Hao, Ying Jin, Isaac J Nijman, Christine Iacobuzio-Donahue, Steven D Leach, Darryl J Pappin, Molly Hammell, David S Klimstra, Olca Basturk, Ralph H Hruban, George Johan Offerhaus, Robert G J Vries, Hans Clevers, David A Tuveson
Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited response to treatment. Tractable methods to identify and interrogate pathways involved in pancreatic tumorigenesis are urgently needed. We established organoid models from normal and neoplastic murine and human pancreas tissues. Pancreatic organoids can be rapidly generated from resected tumors and biopsies, survive cryopreservation, and exhibit ductal- and disease-stage-specific characteristics. Orthotopically transplanted neoplastic organoids recapitulate the full spectrum of tumor development by forming early-grade neoplasms that progress to locally invasive and metastatic carcinomas...
January 15, 2015: Cell
https://www.readbyqxmd.com/read/25334660/a-rare-case-of-pulmonary-lymphangitic-carcinomatosis-as-primary-manifestation-in-a-patient-with-metastatic-pancreatic-cancer
#19
Nabamita Bisen, Vikram Bisen, Subhraleena Das, Robert Lenox
SESSION TITLE: Cancer Case Report Posters ISESSION TYPE: Affiliate Case Report PosterPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Pulmonary lymphangitic carcinomatosis (PLC) is a rare metastatic lung disease, characterized by infiltration of the pulmonary lymphatic system by tumor cells. We present a case where lymphangitic spread in lungs manifesting as dyspnea and cough, was the primary presentation in a patient with metastatic pancreatic cancer. CASE PRESENTATION: A 61 y...
October 1, 2014: Chest
https://www.readbyqxmd.com/read/25275504/further-characterization-of-hdac-and-sirt-gene-expression-patterns-in-pancreatic-cancer-and-their-relation-to-disease-outcome
#20
Mehdi Ouaïssi, Françoise Silvy, Céline Loncle, Diva Ferraz da Silva, Carla Martins Abreu, Emmanuelle Martinez, Patrick Berthézene, Sophie Cadra, Yves Patrice Le Treut, Jean Hardwigsen, Bernard Sastre, Igor Sielezneff, Liliane Benkoel, Jean Delgrande, Ali Ouaissi, Juan Iovanna, Dominique Lombardo, Eric Mas
Ductal adenocarcinoma of the pancreas is ranking 4 for patient' death from malignant disease in Western countries, with no satisfactory treatment. We re-examined more precisely the histone deacetylases (HDAC) and Sirtuin (SIRT) gene expression patterns in pancreatic cancer with more pancreatic tumors and normal tissues. We also examined the possible relationship between HDAC gene expression levels and long term disease outcome. Moreover, we have evaluated by using an in vitro model system of human pancreatic tumor cell line whether HDAC7 knockdown may affect the cell behavior...
2014: PloS One
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