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pancreas ductal cancer biopsy

Kozo Noguchi, Yoshito Tomimaru, Hidetoshi Eguchi, Hisataka Ogawa, Daisaku Yamada, Akira Tomokuni, Takehiro Noda, Tadafumi Asaoka, Hiroshi Wada, Koichi Kawamoto, Kunihito Goto, Shigeru Marubashi, Hiroaki Nagano, Masaki Mori, Yuichiro Doki
Repeated pancreatectomy for metachronous pancreatic cancer has rarely been reported. We report 3 cases with metachronous pancreatic ductal carcinoma that developed after pancreatectomy for the first pancreatic cancer. They were successfully resected by removal of the remnant pancreas. In all 3 cases, the cancers in the remnant pancreas were treated with repeated pancreatectomy. The histological margin of the first pancreatic resection was cancer-free in all the cases. Furthermore, the second cancer tissue contained carcinoma lesions in situ adjacent to invasive ductal carcinoma...
November 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Robert Kleinert, Klaus Prenzel, Nikolas Stoecklein, Hakan Alakus, Elfriede Bollschweiler, Arnulf Hölscher, Ute Warnecke-Eberz
AIM: For tumors of the periampullary region clinical differentiation between primary and tumor-associated pancreatitis might be difficult. Early diagnosis of these malignancies is essential, as they present with early invasion of surrounding tissue thus limiting therapeutic options. Using molecular markers, the preoperative diagnosis (EUS-guided needle biopsy, brush biopsy pancreatic duct) could be optimized and surgical therapy potentially adapted. Alpha1 (XI) collagen Col11A1 is essential for the extracellular matrix and normal skeletal development and has been associated with carcinogenesis...
November 2015: Anticancer Research
Xu Che, Zhihui Zhang, Yantao Tian, Jianwei Zhang, Yingtai Chen, Chengfeng Wang
OBJECTIVE: To evaluate the value of intraoperative fine needle aspiration cytology (IFNAC) examination in the diagnosis of pancreatic lesions. METHODS: The clinicopathological data of 491 patients with pancreatic lesions treated in our hospital from May 1998 to June 2013 were retrospectively analyzed. Their clinical features, IFNAC findings, pathological results after IFNAC examination and related complications were summarized. The factors affecting the aspiration biopsy accuracy were analyzed using logistic regression and multi factor analysis...
May 2015: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Hyeon Jeong Goong, Jong Ho Moon, Hyun Jong Choi, Yun Nah Lee, Moon Han Choi, Hee Kyung Kim, Tae Hoon Lee, Sang-Woo Cha
Cases of pancreatic ductal adenocarcinoma with multiple masses accompanying underlying pancreatic diseases, such as intraductal papillary mucinous neoplasm, have been reported. However, synchronous invasion without underlying pancreatic disease is very rare. A 61-year-old female with abdominal discomfort and jaundice was admitted to our hospital. Abdominal computed tomography (CT) revealed cancer of the pancreatic head with direct invasion of the duodenal loop and common bile duct. However, positron emission tomography-CT showed an increased standardized uptake value (SUV) in the pancreatic head and tail...
September 23, 2015: Gut and Liver
Sophie Schneitler, Patric Kröpil, Jasmin Riemer, Gerald Antoch, Wolfram Trudo Knoefel, Dieter Häussinger, Dirk Graf
Patients with metastasized carcinoma of the pancreas have a very poor prognosis, and long-term survival cannot be expected. This case report describes two patients with an initial diagnosis of metastatic pancreatic cancer, both with hepatic metastases and one with an additional peritoneal carcinomatosis. Initially, both patients were treated intravenously with the FOLFIRINOX chemotherapy regimen, consisting of 5-FU, folinic acid, irinotecan and oxaliplatin. Surprisingly, the FOLFIRINOX treatment resulted in complete resolution of the hepatic metastases in both patients, with no lesions detectable by computed tomography scan...
May 28, 2015: World Journal of Gastroenterology: WJG
Barbara J Kenner, Suresh T Chari, Deborah F Cleeter, Vay Liang W Go
Innovation leading to significant advances in research and subsequent translation to clinical practice is urgently necessary in early detection of sporadic pancreatic cancer. Addressing this need, the Early Detection of Sporadic Pancreatic Cancer Summit Conference was conducted by Kenner Family Research Fund in conjunction with the 2014 American Pancreatic Association and Japan Pancreas Society Meeting. International interdisciplinary scientific representatives engaged in strategic facilitated conversations based on distinct areas of inquiry: Case for Early Detection: Definitions, Detection, Survival, and Challenges; Biomarkers for Early Detection; Imaging; and Collaborative Studies...
July 2015: Pancreas
Suresh T Chari, Kimberly Kelly, Michael A Hollingsworth, Sarah P Thayer, David A Ahlquist, Dana K Andersen, Surinder K Batra, Teresa A Brentnall, Marcia Canto, Deborah F Cleeter, Matthew A Firpo, Sanjiv Sam Gambhir, Vay Liang W Go, O Joe Hines, Barbara J Kenner, David S Klimstra, Markus M Lerch, Michael J Levy, Anirban Maitra, Sean J Mulvihill, Gloria M Petersen, Andrew D Rhim, Diane M Simeone, Sudhir Srivastava, Masao Tanaka, Aaron I Vinik, David Wong
Pancreatic cancer (PC) is estimated to become the second leading cause of cancer death in the United States by 2020. Early detection is the key to improving survival in PC. Addressing this urgent need, the Kenner Family Research Fund conducted the inaugural Early Detection of Sporadic Pancreatic Cancer Summit Conference in 2014 in conjunction with the 45th Anniversary Meeting of the American Pancreatic Association and Japan Pancreas Society. This seminal convening of international representatives from science, practice, and clinical research was designed to facilitate challenging interdisciplinary conversations to generate innovative ideas leading to the creation of a defined collaborative strategic pathway for the future of the field...
July 2015: Pancreas
Lorraine A Chantrill, Adnan M Nagrial, Clare Watson, Amber L Johns, Mona Martyn-Smith, Skye Simpson, Scott Mead, Marc D Jones, Jaswinder S Samra, Anthony J Gill, Nicole Watson, Venessa T Chin, Jeremy L Humphris, Angela Chou, Belinda Brown, Adrienne Morey, Marina Pajic, Sean M Grimmond, David K Chang, David Thomas, Lucille Sebastian, Katrin Sjoquist, Sonia Yip, Nick Pavlakis, Ray Asghari, Sandra Harvey, Peter Grimison, John Simes, Andrew V Biankin
PURPOSE: Personalized medicine strategies using genomic profiling are particularly pertinent for pancreas cancer. The Individualized Molecular Pancreatic Cancer Therapy (IMPaCT) trial was initially designed to exploit results from genome sequencing of pancreatic cancer under the auspices of the International Cancer Genome Consortium (ICGC) in Australia. Sequencing revealed small subsets of patients with aberrations in their tumor genome that could be targeted with currently available therapies...
May 1, 2015: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Meghan R Flanagan, Arjun Jayaraj, Wei Xiong, Matthew M Yeh, Wendy H Raskind, Venu G Pillarisetty
Intraductal papillary mucinous neoplasm (IPMN) is a mucin-producing epithelial neoplasm that carries a risk of progression to invasive pancreatic ductal adenocarcinoma. Lynch syndrome is an autosomal dominant condition caused by germline mutations in mismatch repair genes such as MSH2 that lead to microsatellite instability and increased risk of tumor formation. Although families with Lynch syndrome have an increased risk of pancreatic cancer, a clear connection between Lynch syndrome and IPMN has not been drawn...
March 7, 2015: World Journal of Gastroenterology: WJG
Sylvia F Boj, Chang-Il Hwang, Lindsey A Baker, Iok In Christine Chio, Dannielle D Engle, Vincenzo Corbo, Myrthe Jager, Mariano Ponz-Sarvise, Hervé Tiriac, Mona S Spector, Ana Gracanin, Tobiloba Oni, Kenneth H Yu, Ruben van Boxtel, Meritxell Huch, Keith D Rivera, John P Wilson, Michael E Feigin, Daniel Öhlund, Abram Handly-Santana, Christine M Ardito-Abraham, Michael Ludwig, Ela Elyada, Brinda Alagesan, Giulia Biffi, Georgi N Yordanov, Bethany Delcuze, Brianna Creighton, Kevin Wright, Youngkyu Park, Folkert H M Morsink, I Quintus Molenaar, Inne H Borel Rinkes, Edwin Cuppen, Yuan Hao, Ying Jin, Isaac J Nijman, Christine Iacobuzio-Donahue, Steven D Leach, Darryl J Pappin, Molly Hammell, David S Klimstra, Olca Basturk, Ralph H Hruban, George Johan Offerhaus, Robert G J Vries, Hans Clevers, David A Tuveson
Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited response to treatment. Tractable methods to identify and interrogate pathways involved in pancreatic tumorigenesis are urgently needed. We established organoid models from normal and neoplastic murine and human pancreas tissues. Pancreatic organoids can be rapidly generated from resected tumors and biopsies, survive cryopreservation, and exhibit ductal- and disease-stage-specific characteristics. Orthotopically transplanted neoplastic organoids recapitulate the full spectrum of tumor development by forming early-grade neoplasms that progress to locally invasive and metastatic carcinomas...
January 15, 2015: Cell
Nabamita Bisen, Vikram Bisen, Subhraleena Das, Robert Lenox
SESSION TITLE: Cancer Case Report Posters ISESSION TYPE: Affiliate Case Report PosterPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Pulmonary lymphangitic carcinomatosis (PLC) is a rare metastatic lung disease, characterized by infiltration of the pulmonary lymphatic system by tumor cells. We present a case where lymphangitic spread in lungs manifesting as dyspnea and cough, was the primary presentation in a patient with metastatic pancreatic cancer. CASE PRESENTATION: A 61 y...
October 1, 2014: Chest
Mehdi Ouaïssi, Françoise Silvy, Céline Loncle, Diva Ferraz da Silva, Carla Martins Abreu, Emmanuelle Martinez, Patrick Berthézene, Sophie Cadra, Yves Patrice Le Treut, Jean Hardwigsen, Bernard Sastre, Igor Sielezneff, Liliane Benkoel, Jean Delgrande, Ali Ouaissi, Juan Iovanna, Dominique Lombardo, Eric Mas
Ductal adenocarcinoma of the pancreas is ranking 4 for patient' death from malignant disease in Western countries, with no satisfactory treatment. We re-examined more precisely the histone deacetylases (HDAC) and Sirtuin (SIRT) gene expression patterns in pancreatic cancer with more pancreatic tumors and normal tissues. We also examined the possible relationship between HDAC gene expression levels and long term disease outcome. Moreover, we have evaluated by using an in vitro model system of human pancreatic tumor cell line whether HDAC7 knockdown may affect the cell behavior...
2014: PloS One
Joal D Beane, Kayla F Griffin, Elliot B Levy, Prakash Pandalai, Bradford Wood, Nadine Abi-Jaoudeh, Tatiana Beresnev, Yvonne Shutack, Carole C Webb, Itzhak Avital, Udo Rudloff
BACKGROUND: Regional chemotherapy is used successfully in the treatment of both primary and secondary malignancies, in particular of the peritoneal surface and the liver, and is currently explored as an attractive approach for patients with locally advanced pancreatic ductal adenocarcinoma. To establish the feasibility and toxicity of regional intra-arterial gemcitabine delivered as a 24-h continuous infusion to the pancreas as a novel treatment option for patients with locally advanced PDAC a phase I clinical trial was conducted...
February 2015: Investigational New Drugs
Alan S Wang, Alessia Lodi, Lee B Rivera, Jose L Izquierdo-Garcia, Matthew A Firpo, Sean J Mulvihill, Margaret A Tempero, Gabriele Bergers, Sabrina M Ronen
The prognosis for patients with pancreatic cancer is extremely poor, as evidenced by the disease's five-year survival rate of ~5%. New approaches are therefore urgently needed to improve detection, treatment, and monitoring of pancreatic cancer. MRS-detectable metabolic changes provide useful biomarkers for tumor detection and response-monitoring in other cancers. The goal of this study was to identify MRS-detectable biomarkers of pancreatic cancer that could enhance currently available imaging approaches. We used (1) H high-resolution magic angle spinning MRS to probe metabolite levels in pancreatic tissue samples from mouse models and patients...
November 2014: NMR in Biomedicine
Javier Freire, Saioa Domínguez-Hormaetxe, Saray Pereda, Ana De Juan, Alfonso Vega, Laureano Simón, Javier Gómez-Román
Accurate diagnosis of invasive breast lesions, when analyzed by Core Needle Biopsy, may suppose a major challenge for the pathologist. Various markers of invasiveness such as laminin, S-100 protein, P63 or calponin have been described; however, none of them is completely reliable. The use of a specific marker of the infiltrating tumor microenvironment seems vital to support the diagnosis of invasive against in situ lesions. At this point, Collagen, type XI, alpha 1 (COL11A1), might be helpful since it has been described to be associated to cancer associated fibroblasts in other tumors such as lung, pancreas or colorectal...
December 2014: Pathology, Research and Practice
Min Jung Park, Young Kon Kim, Seo-youn Choi, Hyunchul Rhim, Won Jae Lee, Dongil Choi
PURPOSE: To evaluate the benefit of adding diffusion-weighted ( DW diffusion weighted ) imaging to conventional magnetic resonance (MR) imaging in the preoperative detection of small pancreatic adenocarcinoma (≤ 3.0 cm). MATERIALS AND METHODS: The institutional review board approved this retrospective study and waived the requirement for informed consent. This study included 83 patients (56 men, 27 women) with surgically confirmed pancreatic adenocarcinoma of 3...
November 2014: Radiology
Eun Sun Lee, Jeong Min Lee
Pancreatic cancer (PC) remains one of the deadliest cancers worldwide, and has a poor, five-year survival rate of 5%. Although complete surgical resection is the only curative therapy for pancreatic cancer, less than 20% of newly-diagnosed patients undergo surgical resection with a curative intent. Due to the lack of early symptoms and the tendency of pancreatic adenocarcinoma to invade adjacent structures or to metastasize at an early stage, many patients with pancreatic cancer already have advanced disease at the time of their diagnosis and, therefore, there is a high mortality rate...
June 28, 2014: World Journal of Gastroenterology: WJG
C De Angelis, S F Manfrè, R Pellicano
Endoscopic ultrasound (EUS) is a technique that combines the potential of endoscopy, which enables the visual examination of the mucosal surface of any gastrointestinal (GI) tract, with ultrasonography. Despite diagnostic and therapeutic advance, pancreatic cancer (PC), in particular ductal adenocarcinoma, remains the most deadly of all GI malignancies, with a 5-years survival rate less than 1.8%. Moreover its incidence appears to be increasing and most patients present with advanced cancer either locally or with metastatic spread...
April 2014: Minerva Medica
Katherine Y Fan, Avani S Dholakia, Aaron T Wild, Zheng Su, Amy Hacker-Prietz, Rachit Kumar, Mary Hodgin, Charles C Hsu, Dung T Le, Ana De Jesus-Acosta, Luis A Diaz, Daniel A Laheru, Ralph H Hruban, Elliot K Fishman, Todd D Brown, Timothy M Pawlik, Christopher L Wolfgang, Phuoc T Tran, Joseph M Herman
An association between diabetes mellitus and pancreatic ductal adenocarcinoma (PDA) has long been recognized. This article assesses the effect of the baseline hemoglobin-A1c (HbA1c) value on the clinical outcomes of patients with PDA. HbA1c values were prospectively collected on 656 consecutive patients presenting to a pancreas multidisciplinary cancer clinic from 2009 to 2012. Patients were diagnosed with benign pancreatic disease (BPD) or biopsy-confirmed resectable (R), borderline/locally advanced (BL), or metastatic (M) PDA...
January 2014: Journal of the National Comprehensive Cancer Network: JNCCN
Jon C Henry, Claudio Bassi, Francesco Giovinazzo, Mark Bloomston
INTRODUCTION: Prognostication for cystic neoplasms of the pancreas continues to evolve. Beyond simple size and cystic fluid CEA determination, microRNA (miRNA) detection holds great promise as molecular diagnostics for cancer risk. In this study, we sought to identify miRNAs that could predict malignant potential of pancreatic cystic lesions. METHODS: RNA was harvested from the pancreatic duct aspirate of 72 cystic neoplasms of the pancreas. Samples with adequate RNA concentration (≥ 3 ng/μL) were selected for qRTPCR profiling using assays to 379 of the most common miRNAs...
December 2013: Annals of Surgical Oncology
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