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https://www.readbyqxmd.com/read/28210483/intra-peritoneal-leiomyoma-of-the-round-ligament-in-a-patient-with-mayer-rokitansky-k%C3%A3-ster-hauser-mrkh-syndrome
#1
G Salem Wehbe, R Bitar, T Zreik, M Samaha, C Walter, Z Sleiman
BACKGROUND: The occurrence of an extra-uterine leiomyoma, arising from the intra-peritoneal portion of the round ligament in a lady with Müllerian agenesis diagnosed at the age of forty is extremely rare. We report a case of this rare combination in a Middle Eastern woman. CASE: A 40 years old lady, primarily amenorrheic, presented to our clinic for an infertility consultation. The work- up showed features suggestive of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome with a leiomyoma arising from the intra-peritoneal part of the round ligament...
December 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/28207748/nucleotide-pools-dictate-the-identity-and-frequency-of-ribonucleotide-incorporation-in-mitochondrial-dna
#2
Anna-Karin Berglund, Clara Navarrete, Martin K M Engqvist, Emily Hoberg, Zsolt Szilagyi, Robert W Taylor, Claes M Gustafsson, Maria Falkenberg, Anders R Clausen
Previous work has demonstrated the presence of ribonucleotides in human mitochondrial DNA (mtDNA) and in the present study we use a genome-wide approach to precisely map the location of these. We find that ribonucleotides are distributed evenly between the heavy- and light-strand of mtDNA. The relative levels of incorporated ribonucleotides reflect that DNA polymerase γ discriminates the four ribonucleotides differentially during DNA synthesis. The observed pattern is also dependent on the mitochondrial deoxyribonucleotide (dNTP) pools and disease-causing mutations that change these pools alter both the absolute and relative levels of incorporated ribonucleotides...
February 16, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28202375/generation-and-characterization-of-west-nile-pseudo-infectious-reporter-virus-for-antiviral-screening
#3
Hong-Lei Zhang, Han-Qing Ye, Cheng-Lin Deng, Si-Qing Liu, Pei-Yong Shi, Cheng-Feng Qin, Zhi-Ming Yuan, Bo Zhang
West Nile virus (WNV), a mosquito-borne flavivirus, is an important neurotropic human pathogen. As a biosafety level-3 (BSL-3) agent, WNV is strictly to BSL-3 laboratories for experimentations, thus greatly hindering the development of vaccine and antiviral drug. Here, we developed a novel pseudo-infectious WNV reporter virus expressing the Gaussia luciferase (Gluc). A stable 293TNS1 cell line expressing NS1 was selected for trans-supplying NS1 protein to support the replication of WNV-ΔNS1 virus and WNV-ΔNS1-Gluc reporter virus with large-fragment deletion of NS1...
February 12, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28198079/nurses-perceptions-of-barriers-to-implementing-family-centered-care-in-a-pediatric-setting-a-qualitative-study
#4
Handan Boztepe, Gizem Kerimoğlu Yıldız
PURPOSE: This was a qualitative study conducted to explore the views of nurses regarding the practice of family-centered care (FCC). DESIGN AND METHODS: Eighteen nurses working in different units of a children's hospital in Turkey were included in the study. In-depth interviews were conducted with the nurses to obtain detailed information about their perspectives on FCC activities. RESULTS: Two main themes emerged from the data, each with subthemes...
February 15, 2017: Journal for Specialists in Pediatric Nursing: JSPN
https://www.readbyqxmd.com/read/28192906/coupling-high-throughput-microfluidics-and-small-angle-x-ray-scattering-to-study-protein-crystallization-from-solution
#5
Nhat Pham, Dimitri Radajewski, Adam Round, Martha Brennich, Petra Pernot, Béatrice Biscans, Françoise Bonneté, Sébastien Teychené
In this work, we propose the combination of small-angle X-ray scattering (SAXS) and high throughput, droplet based microfluidics as a powerful tool to investigate macromolecular interactions, directly related to protein solubility. For this purpose, a robust and low cost microfluidic platform was fabricated for achieving the mixing of proteins, crystallization reagents, and buffer in nanoliter volumes and the subsequent generation of nanodroplets by means of a two phase flow. The protein samples are compartmentalized inside droplets, each one acting as an isolated microreactor...
February 8, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28191378/mediterranean-spotted-fever-a-rare-non-endemic-disease-in-the-usa
#6
Joshua Brad Oaks, Glenmore Lasam, Gina LaCapra
We report a case of a 43-year-old Israeli male who presented with an intermittent fever associated with a gradual appearance of diffusely scattered erythematous non-pruritic maculopapular lesions, generalized body malaise, muscle aches, and distal extremity weakness. He works in the Israeli military and has been exposed to dogs that are used to search for people in tunnels and claimed that he had removed ticks from the dogs. In the hospital, he presented with fever, a diffuse maculopapular rash, and an isolated round black eschar...
January 12, 2017: Curēus
https://www.readbyqxmd.com/read/28185593/decentralization-and-health-system-performance-a-focused-review-of-dimensions-difficulties-and-derivatives-in-india
#7
REVIEW
Bhuputra Panda, Harshad P Thakur
INTRODUCTION: One of the principal goals of any health care system is to improve health through the provision of clinical and public health services. Decentralization as a reform measure aims to improve inputs, management processes and health outcomes, and has political, administrative and financial connotations. It is argued that the robustness of a health system in achieving desirable outcomes is contingent upon the width and depth of 'decision space' at the local level. Studies have used different approaches to examine one or more facets of decentralization and its effect on health system functioning; however, lack of consensus on an acceptable framework is a critical gap in determining its quantum and quality...
October 31, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/28182467/characteristics-of-adults-with-psychiatric-disabilities-participating-in-the-federal-disability-programs
#8
Gina A Livermore, Maura Bardos
OBJECTIVE: We use nationally representative data on working-age recipients of Social Security Disability Insurance (SSDI) and Supplemental Security Income (SSI) to profile beneficiaries with psychiatric disabilities and compare them with beneficiaries eligible for SSDI and SSI on the basis of other health conditions. METHOD: Using data from 4 National Beneficiary Survey rounds, we conducted descriptive analyses of the personal and health characteristics and employment experiences of beneficiaries with and without psychiatric disabilities...
February 9, 2017: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/28181310/localization-of-orexin-b-and-receptor-2-for-orexins-in-testicular-cytotypes-of-the-camelid-alpaca-vicugna-pacos
#9
G Liguori, C Squillacioti, L Assisi, N Mirabella, E Langella, A Costagliola, A Vittoria
The orexins A (OxA) and B (OxB) are two hypothalamic peptides involved in many physiological functions of the mammalian body. They act through the binding of two G-coupled receptors named receptor 1 (OX1 ) and receptor 2 (OX2 ) for orexins. The first receptor is specific for OxA, while the second binds both the substances with equal affinity. The orexins and the relative receptors have been traced by means of different techniques also at the periphery of the body and particularly in the adrenals, and in gastrointestinal and genital organs...
February 8, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28179716/a-modified-delphi-process-to-define-competencies-for-assessment-leads-supporting-a-doctor-of-pharmacy-program
#10
Kristin K Janke, Katherine A Kelley, Burgunda V Sweet, Sarah E Kuba
Objective. To define the competencies for individuals designated as assessment leads in colleges and schools of pharmacy. Methods. Twenty-three assessment experts in pharmacy participated in a modified Delphi process to describe competencies for an assessment lead, defined as the individual responsible for curricular assessment and assessment-related to doctor of pharmacy program accreditation. Round 1 asked open-ended questions about knowledge, skills, and attitudes. Round 2 grouped responses for comment and rating for consensus, which was prospectively set at 80%...
December 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28178911/bringing-mini-chalk-talks-to-the-bedside-to-enhance-clinical-teaching
#11
Michael B Pitt, Jay D Orlander
: Chalk talks - where the teacher is equipped solely with a writing utensil and a writing surface - have been used for centuries, yet little has been written about strategies for their use in medical education. Structured education proximal to patient encounters (during rounds, at the bedside, or in between patients in clinic) maximizes the opportunities for clinical learning. This paper presents a strategy to bring mini-chalk talks (MCTs) to the bedside as a practical way to provide relevant clinical teaching by visually framing teachable moments...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28174202/ethics-rounds-ethical-concerns-when-minors-act-as-standardised-patients
#12
Erwin Jiayuan Khoo, Robert D Schremmer, Douglas S Diekema, John D Lantos
When minors are asked to assist medical educators by acting as standardized patients (SPs), there is a potential for the minors to be exploited. Minors deserve protection from exploitation. Such protection has been written into regulations governing medical research and into child labor laws. But there are no similar guidelines for minors' work in medical education. This article addresses the question of whether there should be rules. Should minors be required to give their informed consent or assent? Are there certain practices that could cause harm for the children who become SPs? We present a controversial case and ask a number of experts to consider the ethical issues that arise when minors are asked to act as SPs in medical education...
February 7, 2017: Pediatrics
https://www.readbyqxmd.com/read/28168570/early-enteral-nutrition-in-critically-ill-patients-esicm-clinical-practice-guidelines
#13
REVIEW
Annika Reintam Blaser, Joel Starkopf, Waleed Alhazzani, Mette M Berger, Michael P Casaer, Adam M Deane, Sonja Fruhwald, Michael Hiesmayr, Carole Ichai, Stephan M Jakob, Cecilia I Loudet, Manu L N G Malbrain, Juan C Montejo González, Catherine Paugam-Burtz, Martijn Poeze, Jean-Charles Preiser, Pierre Singer, Arthur R H van Zanten, Jan De Waele, Julia Wendon, Jan Wernerman, Tony Whitehouse, Alexander Wilmer, Heleen M Oudemans-van Straaten
PURPOSE: To provide evidence-based guidelines for early enteral nutrition (EEN) during critical illness. METHODS: We aimed to compare EEN vs. early parenteral nutrition (PN) and vs. delayed EN. We defined "early" EN as EN started within 48 h independent of type or amount. We listed, a priori, conditions in which EN is often delayed, and performed systematic reviews in 24 such subtopics. If sufficient evidence was available, we performed meta-analyses; if not, we qualitatively summarized the evidence and based our recommendations on expert opinion...
February 6, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28164385/learning-to-prescribe-through-co-working-junior-doctors-pharmacists-and-consultants
#14
Christy Noble, Stephen Billett
CONTEXT: Learning to prescribe is challenging for junior doctors. Significant efforts have been made to improve prescribing education, especially in view of the high rates of prescribing errors made by junior doctors. However, considerations of educational options often overlook the fact that learning to prescribe and prescribing practices rely on practice-based interactions with informed practitioners, such as pharmacists and consultants. Pharmacists have long made important contributions to developing prescribing capacities...
February 6, 2017: Medical Education
https://www.readbyqxmd.com/read/28163784/feasibility-of-co2-mitigation-and-carbohydrate-production-by-microalga-scenedesmus-obliquus-cnw-n-used-for-bioethanol-fermentation-under-outdoor-conditions-effects-of-seasonal-changes
#15
Shih-Hsin Ho, Yi-Di Chen, Ching-Yu Chang, Yen-Ying Lai, Chun-Yen Chen, Akihiko Kondo, Nan-Qi Ren, Jo-Shu Chang
BACKGROUND: Although outdoor cultivation systems have been widely used for mass production of microalgae at a relatively low cost, there are still limited efforts on outdoor cultivation of carbohydrate-rich microalgae that were further used as feedstock for fermentative bioethanol production. In particular, the effects of seasonal changes on cell growth, CO2 fixation, and carbohydrate production of the microalgae have not been well investigated. RESULTS: This work demonstrates the feasibility of using outdoor tubular photobioreactors (PBR) for whole-year-round cultivation of a carbohydrate-rich microalga Scenedesmus obliquus CNW-N in southern Taiwan...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28160624/murine-models-of-germinal-center-derived-lymphomas
#16
REVIEW
Parham Ramezani-Rad, Robert C Rickert
The germinal center (GC) reaction is an adaptive immune response to select B cells bearing high-affinity B cell receptors (BCRs) to undergo further differentiation into antibody-producing cells or memory B cells. To drive affinity maturation, (GC) B cells undergo rounds of hypermutation and rapid proliferation, which can enhance susceptibility to malignant transformation. Lymphomas frequently originate from GC B cells, but the etiology for most lymphoma subtypes is unknown. Work in the past decade has more fully documented the mutational landscape in lymphomas, but the impact of these genomic lesions is often difficult to ascertain...
February 1, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28160321/how-family-interactions-about-lifestyle-changes-affect-adolescents-possibilities-for-maintaining-weight-loss-after-a-weight-loss-intervention-a-longitudinal-qualitative-interview-study
#17
Marianne Eg, Kirsten Frederiksen, Marianne Vamosi, Vibeke Lorentzen
AIM: This study aims to examine how family interactions related to lifestyle changes influence adolescents' potential for maintaining weight loss after participating in a weight-loss treatment programme. BACKGROUND: Obesity among adolescents is a large and complex health problem worldwide. Family support is crucial if adolescents are to benefit from weight-loss intervention. DESIGN: Qualitative research interviews with families who participated in a weight-loss programme...
February 3, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28153857/development-validity-and-reliability-testing-of-the-east-midlands-evaluation-tool-emet-for-measuring-impacts-on-trainees-confidence-and-competence-following-end-of-life-care-training
#18
B Whittaker, R Parry, L Bird, S Watson, C Faull
OBJECTIVES: To develop, test and validate a versatile questionnaire, the East Midlands Evaluation Tool (EMET), for measuring effects of end of life care training events on trainees' self-reported confidence and competence. METHODS: A paper-based questionnaire was designed on the basis of the English Department of Health's core competences for end of life care, with sections for completion pretraining, immediately post-training and also for longer term follow-up...
February 2, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28152967/enhancing-a-culture-of-patient-safety-in-an-oncologic-hospital-setting
#19
Shannon Bristow
: 135 Background: Patient safety is a priority for all hospitals and staff members. With approx. 1:10 hospitalized patients experiencing an adverse event(1), healthcare lags behind other industries with regards to safety. Oncology patients have an increased risk of adverse events due to an immunocompromised status, coupled with complex treatments. Cancer Treatment Centers of America at Eastern Regional Medical Center (ERMC) recognized the need to heighten patient safety while maintaining a positive patient experience...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152941/transforming-a-unit-s-culture-to-improve-clinical-outcomes
#20
Theresa Woodrum, Michael Romano
: 243 Background: Leadership identified an unhealthy work environment existed in our Oncology Hematology Special Care Unit (OHSCU). This was evidenced by increased turnover, low National Database of Nursing Quality Indicators (NDNQI), and nurse sensitive quality indicator scores. In the fall of 2014 changes were made to the unit with a goal of creating within the unit a culture of clinical excellence, engagement, professionalism, accountability, and improve staff satisfaction. METHODS: Leadership met to define the future state of the unit and develop a vision statement...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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