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https://www.readbyqxmd.com/read/28109276/introduction-of-microsystems-in-a-level-3-neonatal-intensive-care-unit-an-interprofessional-approach
#1
Salhab El Helou, Samira Samiee-Zafarghandy, Gerhard Fusch, Muzafar Gani Abdul Wahab, Lynda Aliberti, Ahmad Bakry, Deborah Barnard, Joanne Doucette, Enas El Gouhary, Michael Marrin, Carrie-Lynn Meyer, Amit Mukerji, Anne Nwebube, David Pogorzelski, Edward Pugh, Karen Schattauer, Jay Shah, Sandesh Shivananda, Sumesh Thomas, Jennifer Twiss, Connie Williams, Sourabh Dutta, Christoph Fusch
BACKGROUND: Growth of neonatal intensive care units in number and size has raised questions towards ability to maintain continuity and quality of care. Structural organization of intensive care units is known as a key element for maintaining the quality of care of these fragile patients. The reconstruction of megaunits of intensive care to smaller care units within a single operational service might help with provision of safe and effective care. METHODS/DESIGN: The clinical team and patient distribution lay out, admission and discharge criteria and interdisciplinary round model was reorganized to follow the microstructure philosophy...
January 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28108880/unusual-signal-patterns-of-break-apart-fish-probes-used-in-the-diagnosis-of-soft-tissue-sarcomas
#2
Gergő Papp, Dóra Mihály, Zoltán Sápi
Break-apart FISH probes are the most popular and reliable type of FISH probes used to confirm certain pathological diagnoses. The interpretation is usually easy, however, in some instances it is not so unequivocal. Our aim was to reveal and elucidate the problems occurring in the process of evaluation of the break-apart probe results. Altogether 301 soft tissue sarcomas with confirmed molecular tests using break-apart probes were assessed to reveal the frequency and type of unusual signal pattern. Among 89 synovial sarcoma (SS18) 11%, 12 alveolar rhabdomyosarcoma (FOXO1) 50%, 53 myxoid liposarcoma (DDIT3) 7...
January 20, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28106140/gradient-hierarchic-aligned-porosity-sioc-ceramics
#3
Cekdar Vakifahmetoglu, Damla Zeydanli, Murilo Daniel de Mello Innocentini, Fernanda Dos Santos Ribeiro, Paulo Renato Orlandi Lasso, Gian Domenico Soraru
This work describes a simple technique to produce porous ceramics with aligned porosity having very high permeability and specific surface area. SiOC-based compositions were processed from blends of three types of preceramic polymer and a catalyst, followed by curing and pyrolysis. The heating applied from the bottom of molds promoted the nucleation, expansion and rising of gas bubbles, and the creation of a ceramic matrix with axially oriented channels interconnected by small round pores. The samples were analyzed by SEM, tomography, BET, water immersion porosimetry and permeation to gas flow...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28104901/reliability-of-a-clinical-reasoning-viva-assessment-in-an-australian-pre-professional-osteopathy-program-based-on-generalizability-theory
#4
Brett Vaughan, Paul Orrock, Sandra Grace
Clinical reasoning is situation-dependent and case-specific therefore assessment across different patient presentations is warranted. The present study aims to know if reliability of multi-station case-based viva assessment of clinical reasoning in an Australian pre-registration osteopathy program based on generalizability theory. Students (year 4 and 5) and examiners were recruited from the osteopathy program at Southern Cross University, Lismore, Australia. The study took place on a single day in the student teaching clinic...
January 20, 2017: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/28104730/the-effect-of-family-presence-on-rounding-duration-in-the-picu
#5
Priya R Gupta, R Serene Perkins, Rebecca L Hascall, Carolyn F Shelak, Shaban Demirel, Mark T Buchholz
BACKGROUND AND OBJECTIVE: The incorporation of family-centered rounds has become standard in PICUs across the United States. We compared rounding times in our institution, with and without family members present, to determine the effect on total rounding time and work flow. METHODS: This observational study of a convenience sample was conducted over a 17-month period (May 2014-October 2015), accounting for typical seasonal variation in the PICU. The individual patient rounding times for 2657 encounters were recorded...
January 19, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28103871/a-descriptive-survey-study-of-violence-management-and-priorities-among-psychiatric-staff-in-mental-health-services-across-seventeen-european-countries
#6
Seamus Cowman, Anna Björkdahl, Eric Clarke, Georgina Gethin, Jim Maguire
BACKGROUND: In mental health services what is commonplace across international frontiers is that to prevent aggressive patients from harming themselves, other patients or staff, coercive measures and foremost, violence management strategies are required. There is no agreement, recommendations or direction from the EU on which measures of coercion should be practiced across EU countries, and there is no overall one best practice approach. METHODS: The project was conceived through an expert group, the European Violence in Psychiatry Research Group (EViPRG)...
January 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28094588/mechanisms-and-regulation-of-dna-replication-initiation-in-eukaryotes
#7
Matthew W Parker, Michael R Botchan, James M Berger
Cellular DNA replication is initiated through the action of multiprotein complexes that recognize replication start sites in the chromosome (termed origins) and facilitate duplex DNA melting within these regions. In a typical cell cycle, initiation occurs only once per origin and each round of replication is tightly coupled to cell division. To avoid aberrant origin firing and re-replication, eukaryotes tightly regulate two events in the initiation process: loading of the replicative helicase, MCM2-7, onto chromatin by the origin recognition complex (ORC), and subsequent activation of the helicase by its incorporation into a complex known as the CMG...
January 17, 2017: Critical Reviews in Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28089972/a-preliminary-core-domain-set-for-clinical-trials-of-shoulder-disorders-a-report-from-the-omeract-2016-shoulder-core-outcome-set-special-interest-group
#8
Rachelle Buchbinder, Matthew J Page, Hsiaomin Huang, Arianne P Verhagen, Dorcas Beaton, Christian Kopkow, Mario Lenza, Nitin B Jain, Bethan Richards, Pamela Richards, Marieke Voshaar, Danielle van der Windt, Joel J Gagnier
OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) Shoulder Core Outcome Set Special Interest Group (SIG) was established to develop a core outcome set (COS) for clinical trials of shoulder disorders. METHODS: In preparation for OMERACT 2016, we systematically examined all outcome domains and measurement instruments reported in 409 randomized trials of interventions for shoulder disorders published between 1954 and 2015. Informed by these data, we conducted an international Delphi consensus study including shoulder trial experts, clinicians, and patients to identify key domains that should be included in a shoulder disorder COS...
January 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28088047/sliding-doors-did-drama-based-inter-professional-education-improve-the-tensions-round-person-centred-nursing-and-social-care-delivery-for-people-with-dementia-a-mixed-method-exploratory-study
#9
Lindsay Dingwall, Jane Fenton, Timothy B Kelly, John Lee
This educational intervention takes place when the population of older people with dementia is increasing. Health and Social care professionals must work jointly in increasingly complex contexts. Negative attitudes towards older people are cited as a contributor to poor care delivery, including the use of dismissive and/or patronising language, failing to meet fundamental needs and afford choice. 'Sliding Doors to Personal Futures' is a joint, drama-based, educational initiative between NHS Education Scotland and the Scottish Social Services Council, delivered using interprofessional education (IPE) towards encouraging person-centred health and social care...
December 21, 2016: Nurse Education Today
https://www.readbyqxmd.com/read/28080182/multi-professional-perspectives-on-adolescent-and-young-adult-oncology-across-europe-an-e-delphi-survey
#10
Simon A Pini, Faith Gibson, Lorna A Fern, Sue J Morgan, Robert S Phillips, Dan P Stark
The aims of this article are to describe the ongoing development of adolescent and young adult (AYA) cancer services within the European Union (EU), and to develop consensus on key areas within the field. This survey used an e-Delphi design. An initial survey was distributed via email to professionals working in Europe. A snowball sampling technique was used to promote distribution. Consensus was sought over three rounds from October 2012 to April 2015. Consensus was defined as >80% agreement ("agree" or "strongly agree")...
January 12, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28078889/quantification-of-free-polyelectrolytes-present-in-colloidal-suspension-revealing-a-source-of-toxic-responses-for-polyelectrolyte-wrapped-gold-nanoparticles
#11
Tian A Qiu, Marco D Torelli, Ariane M Vartanian, Nathan B Rackstraw, Joseph T Buchman, Lisa M Jacob, Catherine J Murphy, Robert J Hamers, Christy L Haynes
Polyelectrolyte (PE) wrapping of colloidal nanoparticles (NPs) is a standard method to control NP surface chemistry and charge. Because excess polyelectrolytes are usually employed in the surface modification process, it is critical to evaluate different purification strategies to obtain a clean final product and thus avoid ambiguities in the source of effects on biological systems. In this work, 4 nm diameter gold nanoparticles (AuNPs) were wrapped with 15 kDa poly(allylamine hydrochloride) (PAH), and three purification strategies were applied: (a) diafiltration or either (b) one round or (c) two rounds of centrifugation...
January 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28077563/the-bioc-biogrid-corpus-full-text-articles-annotated-for-curation-of-protein-protein-and-genetic-interactions
#12
Rezarta Islamaj Doğan, Sun Kim, Andrew Chatr-Aryamontri, Christie S Chang, Rose Oughtred, Jennifer Rust, W John Wilbur, Donald C Comeau, Kara Dolinski, Mike Tyers
A great deal of information on the molecular genetics and biochemistry of model organisms has been reported in the scientific literature. However, this data is typically described in free text form and is not readily amenable to computational analyses. To this end, the BioGRID database systematically curates the biomedical literature for genetic and protein interaction data. This data is provided in a standardized computationally tractable format and includes structured annotation of experimental evidence. BioGRID curation necessarily involves substantial human effort by expert curators who must read each publication to extract the relevant information...
2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/28074221/exploring-the-thermostable-properties-of-halohydrin-dehalogenase-from-agrobacterium-radiobacter-ad1-by-a-combinatorial-directed-evolution-strategy
#13
Zhiyun Wu, Wenfeng Deng, Yapei Tong, Qian Liao, Dongmin Xin, Huashun Yu, Juan Feng, Lixia Tang
As a crucial factor for biocatalysts, protein thermostability often arises from a combination of factors that are often difficult to rationalize. In this work, the thermostable nature of halohydrin dehalogenase from Agrobacterium radiobacter AD1 (HheC) was systematically explored using a combinatorial directed evolution approach. For this, a mutagenesis library of HheC mutants was first constructed using error-prone PCR with low mutagenesis frequency. After screening approximately 2000 colonies, six mutants with eight mutation sites were obtained...
January 10, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28074173/radiological-clinical-trials-proposal-of-a-problem-finding-questionnaire-to-improve-study-success
#14
Francesca Valdora, Bianca Bignotti, Massimo Calabrese, Nehmat Houssami, Alberto Tagliafico
AIM: To develop a survey to help define the main problems in radiological clinical trials. METHODS: Since 2006, we have managed seven different radiological clinical trials recruiting patients in academic and non-academic centres. We developed a preliminary questionnaire using a four-round Delphi approach to identify problems occurring in radiological clinical trials run at our centre. We investigated the recruitment experience, involvement of all multi-disciplinary team members and main obstacles to completing the projects...
December 26, 2016: World Journal of Methodology
https://www.readbyqxmd.com/read/28072818/glucose-abl1-tor-signaling-modulates-cell-cycle-tuning-to-control-terminal-appressorial-cell-differentiation
#15
Margarita Marroquin-Guzman, Guangchao Sun, Richard A Wilson
The conserved target of rapamycin (TOR) pathway integrates growth and development with available nutrients, but how cellular glucose controls TOR function and signaling is poorly understood. Here, we provide functional evidence from the devastating rice blast fungus Magnaporthe oryzae that glucose can mediate TOR activity via the product of a novel carbon-responsive gene, ABL1, in order to tune cell cycle progression during infection-related development. Under nutrient-free conditions, wild type (WT) M. oryzae strains form terminal plant-infecting cells (appressoria) at the tips of germ tubes emerging from three-celled spores (conidia)...
January 10, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28071867/identifying-effective-nurse-led-care-transition-interventions-for-older-adults-with-complex-needs-using-a-structured-expert-panel
#16
Lianne Jeffs, Kerry Kuluski, Madelyn Law, Marianne Saragosa, Sherry Espin, Ella Ferris, Jane Merkley, Brenda Dusek, Monika Kastner, Chaim M Bell
BACKGROUND: Nursing plays a central role in facilitating care transitions for complex older adults, yet there is no consensus of the components of nurse-led care transitions interventions to facilitate high quality care transitions among complex older adults. A structured expert panel was established with the purpose of identifying effective nurse-led care transition interventions. METHODS: A modified Delphi consensus technique based on the RAND method was employed...
January 10, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28069627/what-aspects-of-intentional-rounding-work-in-hospital-wards-for-whom-and-in-what-circumstances-a-realist-evaluation-protocol
#17
Ruth Harris, Sarah Sims, Ros Levenson, Stephen Gourlay, Fiona Ross Cbe, Nigel Davies, Sally Brearley, Giampiero Favato, Robert Grant
INTRODUCTION: Intentional rounding (IR) is a structured process whereby nurses in hospitals carry out regular checks, usually hourly, with individual patients using a standardised protocol to address issues of positioning, pain, personal needs and placement of items. The widespread implementation of IR across the UK has been driven by the recommendations of the Francis Inquiry although empirical evidence of its effectiveness is poor. This paper presents a protocol of a multimethod study using a realist evaluation approach to investigate the impact and effectiveness of IR in hospital wards on the organisation, delivery and experience of care from the perspective of patients, their family members and staff...
January 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28069045/improving-nursing-home-care-through-feedback-on-performance-data-inform-protocol-for-a-cluster-randomized-trial
#18
Matthias Hoben, Peter G Norton, Liane R Ginsburg, Ruth A Anderson, Greta G Cummings, Holly J Lanham, Janet E Squires, Deanne Taylor, Adrian S Wagg, Carole A Estabrooks
BACKGROUND: Audit and feedback is effective in improving the quality of care. However, methods and results of international studies are heterogeneous, and studies have been criticized for a lack of systematic use of theory. In TREC (Translating Research in Elder Care), a longitudinal health services research program, we collect comprehensive data from care providers and residents in Canadian nursing homes to improve quality of care and life of residents, and quality of worklife of caregivers...
January 10, 2017: Trials
https://www.readbyqxmd.com/read/28065486/biologic-disease-modifying-antirheumatic-drug-attributes-in-the-first-lines-of-treatment-of-rheumatoid-arthritis-2015-acordar-project
#19
Santiago Muñoz-Fernández, María Sagrario Bustabad Reyes, Jaime Calvo Alén, Manuel Castaño Sánchez, Eugenio Chamizo Carmona, Héctor Corominas, Nagore Fernández-Llanio Comella, María Cristina Hidalgo Calleja, José Javier Pérez Venegas, José Manuel Rodríguez Heredia, Susana María Romero Yuste, Virginia Ruiz-Esquide Torino
OBJECTIVE: To date, between 17% and 35% of patients with rheumatoid arthritis (RA) do not respond as expected to the initial biological therapy. The objective of this project is to recognize and weigh the attributes of biologic DMARD (bDMARD) to identify the most appropriate for each case, in the first lines of treatment of RA (after inadequate response to at least one synthetic DMARD or previous bDMARD). METHODS: To recognize the possible attributes that could define the bDMARD, we performed a systematic search of the literature that recognized the possible attributes involving general aspects, pharmacology, efficacy, safety, management, and cost...
January 3, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28064168/the-competencies-of-registered-nurses-working-in-care-homes-a-modified-delphi-study
#20
Miriam Ruth Stanyon, Sarah Elizabeth Goldberg, Anita Astle, Amanda Griffiths, Adam Lee Gordon
BACKGROUND: registered Nurses (RNs) working in UK care homes receive most of their training in acute hospitals. At present the role of care home nursing is underdeveloped and it is seen as a low status career. We describe here research to define core competencies for RNs working in UK care homes. METHODS: a two-stage process was adopted. A systematic literature review and focus groups with stakeholders provided an initial list of competencies. The competency list was modified over three rounds of a Delphi process with a multi-disciplinary expert panel of 28 members...
January 6, 2017: Age and Ageing
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