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https://www.readbyqxmd.com/read/28546269/towards-an-expert-consensus-to-delineate-a-clinical-syndrome-of-chronic-breathlessness
#1
Miriam J Johnson, Janelle Yorke, John Hansen-Flaschen, Robert Lansing, Magnus Ekström, Thomas Similowski, David C Currow
Breathlessness that persists despite treatment for the underlying conditions is debilitating. Identifying this discrete entity as a clinical syndrome should raise awareness amongst patients, clinicians, service providers, researchers and research funders.Using the Delphi method, questions and statements were generated via expert group consultations and one-to-one interviews (n=17). These were subsequently circulated in three survey rounds (n=34, n=25, n=31) to an extended international group from various settings (clinical and laboratory; hospital, hospice and community) and working within the basic sciences and clinical specialties...
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28543269/building-expert-agreement-on-the-importance-and-feasibility-of-workplace-health-promotion-interventions-for-nurses-and-midwives-a-modified-delphi-consultation
#2
Lin Perry, Rachel Nicholls, Christine Duffield, Robyn Gallagher
AIM: To use a Delphi panel to determine the relative importance and feasibility of workplace health promotion interventions to promote and support the health of the Australian nursing and midwifery workforce BACKGROUND: The nursing workforce experiences rates of ill health above that of other workforces yet there is little investment in workplace health promotion. DESIGN: The study used a modified Delphi design conducted between September - November 2015. METHODS: Eleven of 19 purposively selected expert panellists discussed, rated and provided feedback through two rounds of an electronic questionnaire about the relative importance and feasibility of 46 workplace health promotion interventions and processes for nurses and midwives...
May 24, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28542562/identification-and-characteristics-of-extracellular-vesicles-from-bovine-blastocysts-produced-in-vitro
#3
Edwin A Mellisho, Alejandra E Velásquez, María J Nuñez, Joel G Cabezas, Juan A Cueto, Claudio Fader, Fidel O Castro, Lleretny Rodríguez-Álvarez
Extracellular vesicles (EVs) have been identified within different body fluids and cell culture media. However, there is very little information on the secretion of these vesicles during early embryonic development. The aims of this work were first to demonstrate the secretion of extracellular vesicles by pre-implantation bovine embryos and second to identify and characterize the population of EVs secreted by bovine blastocysts during the period from day seven to nine of embryo culture and its correlation with further embryo development up to day 11...
2017: PloS One
https://www.readbyqxmd.com/read/28542172/ecosystem-sentinels-for-climate-change-evidence-of-wetland-cover-changes-over-the-last-30-years-in-the-tropical-andes
#4
Olivier Dangles, Antoine Rabatel, Martin Kraemer, Gabriel Zeballos, Alvaro Soruco, Dean Jacobsen, Fabien Anthelme
While the impacts of climate change on individual species and communities have been well documented there is little evidence on climate-mediated changes for entire ecosystems. Pristine alpine environments can provide unique insights into natural, physical and ecological response to climate change yet broad scale and long-term studies on these potential 'ecosystem sentinels' are scarce. We addressed this issue by examining cover changes of 1689 high-elevation wetlands (temporarily or perennial water-saturated grounds) in the Bolivian Cordillera Real, a region that has experienced significant warming and glacier melting over the last 30 years...
2017: PloS One
https://www.readbyqxmd.com/read/28533184/multi-institutional-development-of-a-mastoidectomy-performance-evaluation-instrument
#5
Thomas Kerwin, Brad Hittle, Don Stredney, Paul De Boeck, Gregory Wiet
OBJECTIVE: A method for rating surgical performance of a mastoidectomy procedure that is shown to apply universally across teaching institutions has not yet been devised. This work describes the development of a rating instrument created from a multi-institutional consortium. DESIGN: Using a participatory design and a modified Delphi approach, a multi-institutional group of expert otologists constructed a 15-element task-based checklist for evaluating mastoidectomy performance...
May 20, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28532845/characterization-of-undifferentiated-spermatogonia-and-the-spermatogonial-niche-in-the-lambari-fish-astyanax-altiparanae
#6
Marília de Paiva Camargo, Mônica Cassel, Lázaro Wender Oliveira de Jesus, Rafael Henrique Nóbrega, Maria Inês Borella
Undifferentiated type A spermatogonia are the foundation of fish spermatogenesis. This cell population includes the spermatogonial stem cell population, which is able to either self-renew or differentiate into cells that will generate the male gamete - the spermatozoa. Spermatogonia stem cells are located in a specific region of the testes known as the spermatogonial niche, which regulates spermatogonial stem cell function. This study characterizes undifferentiated type A spermatogonia and their S-phase label-retaining cell properties in Astyanax altiparanae testes...
July 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28532440/uptake-of-hiv-testing-in-burkina-faso-an-assessment-of-individual-and-community-level-determinants
#7
Fati Kirakoya-Samadoulougou, Kévin Jean, Mathieu Maheu-Giroux
BACKGROUND: Previous studies have highlighted a range of individual determinants associated with HIV testing but few have assessed the role of contextual factors. The objective of this paper is to examine the influence of both individual and community-level determinants of HIV testing uptake in Burkina Faso. METHODS: Using nationally representative cross-sectional data from the 2010 Demographic and Health Survey, the determinants of lifetime HIV testing were examined for sexually active women (n = 14,656) and men (n = 5680) using modified Poisson regression models...
May 22, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28530537/aspergillus-fischeri-mediated-biosynthesis-of-gold-nanoparticles-and-their-beneficially-comparative-effect-on-normal-and-cancer-cell-lines
#8
Kangkana Banerjee, Ravishankar Rai Vittal
Background Along with the intensified use of metal nanoparticles, growing concern of their adverse outcome on human health has also expanded, indicating that this work is an integral part of nanobioscience study. Objective The aim of this study was to evaluate varied effect of biosynthesized gold nanoparticles (AuNPs) on normal and cancerous mammalian cells. Methods AuNP synthesized and characterized by different characterization methods, here are produced by specifically isolated Aspergillus species, which is hardly explored in precious scientific findings...
May 22, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28528878/occupational-prognosis-factors-for-ulnar-nerve-entrapment-at-the-elbow-a-systematic-review
#9
M Fadel, R Lancigu, G Raimbeau, Y Roquelaure, A Descatha
Although ulnar nerve entrapment is the second most common entrapment neuropathy, there is a dearth of studies identifying occupational prognosis factors. We carried out a systematic review of the occupational prognosis factors for ulnar nerve entrapment in order to identify professions at risks and allow better follow-up for their workers. Using the key words, "ulnar OR cubital", "neuropathy OR tunnel", and "work OR occupational" without limitations, original prospective studies were selected from four databases (PubMed, Embase, Web of Science, Cochrane Library) after two rounds (valid design, valid prognosis outcome reported, valid work exposure)...
May 18, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28526055/developing-a-proxy-version-of-the-adult-social-care-outcome-toolkit-ascot
#10
Stacey Rand, James Caiels, Grace Collins, Julien Forder
BACKGROUND: Social care-related quality of life is a key outcome indicator used in the evaluation of social care interventions and policy. It is not, however, always possible to collect quality of life data by self-report even with adaptations for people with cognitive or communication impairments. A new proxy-report version of the Adult Social Care Outcomes Toolkit (ASCOT) measure of social care-related quality of life was developed to address the issues of wider inclusion of people with cognitive or communication difficulties who may otherwise be systematically excluded...
May 19, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28525510/zika-virus-obstetric-and-pediatric-anesthesia-considerations
#11
Jacqueline L Tutiven, Benjamin T Pruden, James S Banks, Mario Stevenson, David J Birnbach
As of November 2016, the Florida Department of Health (FDH) and the Centers for Disease Control and Prevention have confirmed more than 4000 travel-related Zika virus (ZIKV) infections in the United States with >700 of those in Florida. There have been 139 cases of locally acquired infection, all occurring in Miami, Florida. Within the US territories (eg, Puerto Rico, US Virgin Islands), >30,000 cases of ZIKV infection have been reported. The projected number of individuals at risk for ZIKV infection in the Caribbean and Latin America approximates 5 million...
June 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28512714/comparison-of-the-diagnostic-accuracy-of-pet-mri-to-pet-ct-acquired-fdg-brain-exams-for-seizure-focus-detection-a-prospective-study
#12
Michael J Paldino, Erica Yang, Jeremy Y Jones, Nadia Mahmood, Andrew Sher, Wei Zhang, Shireen Hayatghaibi, Ramkumar Krishnamurthy, Victor Seghers
BACKGROUND: There is great interest in positron emission tomography (PET)/magnetic resonance (MR) as a clinical tool due to its capacity to provide diverse diagnostic information in a single exam. OBJECTIVE: The goal of this exam is to compare the diagnostic accuracy of PET/MR-acquired [F-18]2-fluoro-2-deoxyglucose (FDG) brain exams to that of PET/CT with respect to identifying seizure foci in children with localization-related epilepsy. MATERIALS AND METHODS: Institutional Review Board approval and informed consent were obtained for this Health Insurance Portability and Accountability Act-compliant, prospective study...
May 16, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28510459/efficient-round-trip-time-optimization-for-replica-exchange-enveloping-distribution-sampling-re-eds
#13
Dominik Sidler, Michael Cristòfol-Clough, Sereina Riniker
Replica-exchange enveloping distribution sampling (RE-EDS) allows the efficient estimation of free-energy differences between multiple end-states from a single molecular dynamics (MD) simulation. In EDS, a reference state is sampled, which can be tuned by two types of parameters, i.e., smoothness parameters(s) and energy offsets, such that all end-states are sufficiently sampled. However, the choice of these parameters is not trivial. Replica exchange (RE) or parallel tempering is a widely applied technique to enhance sampling...
May 26, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28509821/minimum-information-for-studies-evaluating-biologics-in-orthopaedics-mibo-platelet-rich-plasma-and-mesenchymal-stem-cells
#14
Iain R Murray, Andrew G Geeslin, Ewan B Goudie, Frank A Petrigliano, Robert F LaPrade
BACKGROUND: A comprehensive approach to the evaluation of biologic therapies for musculoskeletal conditions is required to guide appropriate future use. Clinical studies evaluating platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) are limited by inadequate reporting of scientific details critical to outcome. We developed minimum reporting requirements for clinical studies evaluating PRP and MSCs using Delphi consensus methods. METHODS: The need for consensus on the minimum reporting requirements for studies evaluating biologics was identified at the American Academy of Orthopaedic Surgeons/Orthopaedic Research Society (AAOS/ORS) Biologic Treatments for Orthopaedic Injuries Symposium in 2015 and the American Orthopaedic Society for Sports Medicine (AOSSM) Biologic Treatments for Sports Injuries II Think Tank in 2015...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28497692/molecular-iodine-mediated-%C3%AE-c-h-oxidation-of-pyrrolidines-to-n-o-acetals-synthesis-of-%C3%A2-preussin-by-late-stage-2-5-difunctionalizations-of-pyrrolidine
#15
Hao-Jie Rong, Jun-Jun Yao, Ji-Kun Li, Jin Qu
We previously reported an iterative synthesis of unsymmetrical 2,5-disubstituted pyrrolidines from pyrrolidine by two rounds of redox-triggered α-C-H functionalization. Although this approach can be used to introduce substituents at the 2- and 5-positions, it is lengthy because the redox auxiliary must be removed and then reinstalled. Therefore, we sought to develop a method to oxidize 2-functionalized pyrrolidine to cyclic N,O-acetal which could then react with a nucleophile for introduction of the 5-substituent...
May 18, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28495353/identifying-patient-related-information-problems-a-study-of-information-use-by-patient-care-teams-during-morning-rounds
#16
Alison R Murphy, Madhu C Reddy
OBJECTIVE: This study identifies the types of patient-related information problems (PIPs) that patient-care teams encounter during morning rounds, and how those PIPs are identified and managed. PIPs are any issues related to patient information (e.g., wrong, missing, incomplete information) that affect the patient-care team's ability to perform their work. Not addressing PIPs can lead to workflow challenges, delayed patient-care decisions, and negative impacts to the patient. MATERIALS AND METHODS: We employed qualitative data collection methods by shadowing patient-care teams during 29 morning rounds resulting in 155h of observation...
June 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28494215/potential-ultrastructure-predicting-factors-for-hepatocellular-carcinoma-in-hcv-infected-patients
#17
Soheir S Mansy, Eman El-Ahwany, Soheir Mahmoud, Sara Hassan, Mohammed I Seleem, Amr Abdelaal, Ahmed H Helmy, Mona K Zoheiry, Ahmed S AbdelFattah, Moataz H Hassanein
Hepatitis C virus represents one of the rising causes of hepatocellular carcinoma (HCC). Although the early diagnosis of HCC is vital for successful curative treatment, the majority of lesions are diagnosed in an irredeemable phase. This work deals with a comparative ultrastructural study of experimentally gradually induced HCC, surgically resected HCC, and potential premalignant lesions from HCV-infected patients, with the prospect to detect cellular criteria denoting premalignant transformation. Among the main detected pathological changes which are postulated to precede frank HCC: failure of normal hepatocyte regeneration with star shape clonal fragmentation, frequent elucidation of hepatic progenitor cells and Hering canals, hepatocytes of different electron density loaded with small sized rounded monotonous mitochondria, increase junctional complexes bordering bile canaliculi and in between hepatocyte membranes, abundant cellular proteinaceous material with hypertrophied or vesiculated rough endoplasmic reticulum (RER), sequestrated nucleus with proteinaceous granular material or hypertrophied RER, formation of lipolysosomes, large autophagosomes, and micro-vesicular fat deposition...
May 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28487723/genome-silencing-and-elimination-insights-from-a-selfish-b-chromosome
#18
REVIEW
John C Aldrich, Patrick M Ferree
B chromosomes are non-essential components of numerous plant and animal genomes. Because many of these "extra" chromosomes enhance their own transmission in ways that are detrimental to the rest of the genome, they can be thought of as genome parasites. An extreme example is a paternally inherited B chromosome known as paternal sex ratio (PSR), which is found in natural populations of the jewel wasp Nasonia vitripennis. In order to ensure its own propagation, PSR severely biases the wasp sex ratio by converting diploid female-destined embryos into transmitting haploid males...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28486554/calculated-thickness-dependent-plasmonic-properties-of-gold-nanobars-in-the-visible-to-near-infrared-light-regime
#19
Pijush K Ghosh, Desalegn T Debu, David A French, Joseph B Herzog
Metallic, especially gold, nanostructures exhibit plasmonic behavior in the visible to near-infrared light range. In this study, we investigate optical enhancement and absorption of gold nanobars with different thicknesses for transverse and longitudinal polarizations using finite element method simulations. This study also reports on the discrepancy in the resonance wavelengths and optical enhancement of the sharp-corner and round-corner nanobars of constant length 100 nm and width 60 nm. The result shows that resonance amplitude and wavelength have strong dependences on the thickness of the nanostructure as well as the sharpness of the corners, which is significant since actual fabricated structure often have rounded corners...
2017: PloS One
https://www.readbyqxmd.com/read/28481780/round-window-application-of-an-active-middle-ear-implant-a-comparison-with-hearing-aid-usage-in-japan
#20
Satoshi Iwasaki, Shin-Ichi Usami, Haruo Takahashi, Yukihiko Kanda, Tetsuya Tono, Katsumi Doi, Kozo Kumakawa, Kiyofumi Gyo, Yasushi Naito, Sho Kanzaki, Noboru Yamanaka, Kimitaka Kaga
OBJECTIVE: To report on the safety and efficacy of an investigational active middle ear implant (AMEI) in Japan, and to compare results to preoperative results with a hearing aid. DESIGN: Prospective study conducted in Japan in which 23 Japanese-speaking adults suffering from conductive or mixed hearing loss received a VIBRANT SOUNDBRIDGE with implantation at the round window. Postoperative thresholds, speech perception results (word recognition scores, speech reception thresholds, signal-to-noise ratio [SNR]), and quality of life questionnaires at 20 weeks were compared with preoperative results with all patients receiving the same, best available hearing aid (HA)...
May 5, 2017: Otology & Neurotology
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