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https://www.readbyqxmd.com/read/28912831/genome-sequencing-and-transcriptome-analysis-of-trichoderma-reesei-qm9978-strain-reveals-a-distal-chromosome-translocation-to-be-responsible-for-loss-of-vib1-expression-and-loss-of-cellulase-induction
#1
Christa Ivanova, Jonas Ramoni, Thiziri Aouam, Alexa Frischmann, Bernhard Seiboth, Scott E Baker, Stéphane Le Crom, Sophie Lemoine, Antoine Margeot, Frédérique Bidard
BACKGROUND: The hydrolysis of biomass to simple sugars used for the production of biofuels in biorefineries requires the action of cellulolytic enzyme mixtures. During the last 50 years, the ascomycete Trichoderma reesei, the main source of industrial cellulase and hemicellulase cocktails, has been subjected to several rounds of classical mutagenesis with the aim to obtain higher production levels. During these random genetic events, strains unable to produce cellulases were generated...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28911198/loss-of-native-%C3%AE-synuclein-multimerization-by-strategically-mutating-its-amphipathic-helix-causes-abnormal-vesicle-interactions-in-neuronal-cells
#2
Ulf Dettmer, Nagendran Ramalingam, Victoria E von Saucken, Tae-Eun Kim, Andrew J Newman, Elizabeth Terry-Kantor, Silke Nuber, Maria Ericsson, Saranna Fanning, Tim Bartels, Susan Lindquist, Oren A Levy, Dennis Selkoe
α-Synuclein (αS) forms round cytoplasmic inclusions in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Evidence suggests a physiological function of αS in vesicle trafficking and release. In contrast to earlier tenets, recent work indicates that αS normally exists in cells in a dynamic equilibrium between monomers and tetramers/multimers. We engineered αS mutants incapable of multimerization, leading to excess monomers at vesicle membranes. By EM, such mutants induced prominent vesicle clustering, leading to round cytoplasmic inclusions...
September 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28902768/economic-and-clinical-outcomes-resulting-from-the-stage-4-chronic-kidney-disease-case-management-quality-improvement-initiative
#3
Beverly Everett, Liana D Castel, Matthew McGinnis, Amy Beresky, Rudolph C Cane, Tasha Cooper, Rajesh K Davda, Donna Farmer, Stella M John, Denise L Sollars, John F Rausch
PURPOSE OF STUDY: Chronic kidney disease (CKD) is a costly and burdensome public health concern. The goal of this study was to evaluate the impact on outcomes and utilization of a pilot program to identify and engage beneficiaries with CKD at risk for progression from Stage 4 to Stage 5. PRIMARY PRACTICE SETTINGS: A quality improvement initiative was conducted to assess the impact of case management on costs and outcomes among 7,720 Cigna commercial medical beneficiaries with Stage 4 CKD enrolled in the United States between January 2012 and October 2012...
September 11, 2017: Professional Case Management
https://www.readbyqxmd.com/read/28902008/fibrous-catalyst-enhanced-acanthamoeba-disinfection-by-hydrogen-peroxide
#4
Simon Kilvington, Lynn Winterton
SIGNIFICANCE: Hydrogen peroxide (H2O2) disinfection systems are contact-lens-patient problem solvers. The current one-step, criterion-standard version has been widely used since the mid-1980s, without any significant improvement. This work identifies a potential next-generation, one-step H2O2, not based on the solution formulation but rather on a case-based peroxide catalyst. PURPOSE: One-step H2O2 systems are widely used for contact lens disinfection. However, antimicrobial efficacy can be limited because of the rapid neutralization of the peroxide from the catalytic component of the systems...
September 9, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28900069/current-issues-and-improvement-of-the-korea-dental-hygienist-national-licensing-examination-a-dental-hygienists-expert-delphi-survey
#5
Yoon-Sook Hwang, Hyun-Sook Kang, Soo-Hwa Kim, Hee-Jung Moon, Sun-Mi Lee, Jae-Yeon Jung, Su-Jeong Hwang, Jung-Eun Ha
Purpose: This study aimed to investigate the current issue and improvement issue of the Korea Dental Hygienist National Licensing Examination (KDHNLE) through expert Delphi survey. Methods: Delphi survey was conducted from May through August, 2016 in Korea. This Delphi survey included 20 persons who represent dental hygiene (seven groups of dental hygiene-related organizations). Delphi survey was applied as 3 round questionnaire surveys though e-mail regarding the issues and solutions of the KDHNLE...
September 13, 2017: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/28893473/data-and-product-needs-for-influenza-immunization-programs-in-low-and-middle-income-countries-rationale-and-main-conclusions-of-the-who-preferred-product-characteristics-for-next-generation-influenza-vaccines
#6
Kathleen M Neuzil, Joseph S Bresee, Fernando de la Hoz, Kari Johansen, Ruth A Karron, Anand Krishnan, Shabir A Madhi, Punam Mangtani, David J Spiro, Justin R Ortiz
In 2017, WHO convened a working group of global experts to develop the Preferred Product Characteristics (PPC) for Next-Generation Influenza Vaccines. PPCs are intended to encourage innovation in vaccine development. They describe WHO preferences for parameters of vaccines, in particular their indications, target groups, implementation strategies, and clinical data needed for assessment of safety and efficacy. PPCs are shaped by the global unmet public health need in a priority disease area for which WHO encourages vaccine development...
September 8, 2017: Vaccine
https://www.readbyqxmd.com/read/28890830/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-combined-with-two-stage-hepatectomy-for-multiple-and-bilobar-desmoplastic-small-round-cell-tumor-liver-metastases
#7
Alejandro Cracco, Mayank Roy, Conrad H Simpfendorfer
Desmoplastic small round cell tumor (DSRCT) is a rare mesenchymal tumor usually affecting young patients. Local dissemination is common, and liver is the most common site for extraperitoneal metastases. Multimodal management has been shown to be the most effective treatment. Some authors consider liver metastases especially bi-lobar disease as a contraindication for surgical resection. We present a case of a DSRCT with bi-lobar metastases in an adult patient who underwent multi-modal management along with hepatectomy...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28887786/assessing-psycho-social-barriers-to-rehabilitation-in-injured-workers-with-chronic-musculoskeletal-pain-development-and-item-properties-of-the-yellow-flag-questionnaire-yfq
#8
Cornelia Rolli Salathé, Maurizio Alen Trippolini, Livio Claudio Terribilini, Michael Oliveri, Achim Elfering
Purpose To develop a multidimensional scale to asses psychosocial beliefs-the Yellow Flag Questionnaire (YFQ)-aimed at guiding interventions for workers with chronic musculoskeletal (MSK) pain. Methods Phase 1 consisted of item selection based on literature search, item development and expert consensus rounds. In phase 2, items were reduced with calculating a quality-score per item, using structure equation modeling and confirmatory factor analysis on data from 666 workers. In phase 3, Cronbach's α, and Pearson correlations coefficients were computed to compare YFQ with disability, anxiety, depression and self-efficacy and the YFQ score based on data from 253 injured workers...
September 8, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/28882107/statistical-classifiers-for-diagnosing-disease-from-immune-repertoires-a-case-study-using-multiple-sclerosis
#9
Jared Ostmeyer, Scott Christley, William H Rounds, Inimary Toby, Benjamin M Greenberg, Nancy L Monson, Lindsay G Cowell
BACKGROUND: Deep sequencing of lymphocyte receptor repertoires has made it possible to comprehensively profile the clonal composition of lymphocyte populations. This opens the door for novel approaches to diagnose and prognosticate diseases with a driving immune component by identifying repertoire sequence patterns associated with clinical phenotypes. Indeed, recent studies support the feasibility of this, demonstrating an association between repertoire-level summary statistics (e.g., diversity) and patient outcomes for several diseases...
September 7, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28880614/professional-and-political-reflections-on-the-grand-round-a-critical-case-study
#10
Dan Cooper, Dave Mercer
This case study presents a critical reflective account of a change to working practices in one NHS Trust. To promote quality care and effective clinical decision making, a 'grand round' was introduced in the orthopaedic department. Implementation presented frustrations and challenges for members of the multidisciplinary team. These are explored using transformative learning and critical reflection, enabling connections to be made between micro-level interactions of clinical care and macro-level structures that frame healthcare services...
September 7, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28879825/changes-in-consumption-of-food-away-from-home-and-intakes-of-energy-and-other-nutrients-among-us-working-age-adults-2005-2014
#11
Jessica E Todd
OBJECTIVE: To document changes in consumption of food away from home (FAFH) and intakes of selected nutrients by working-age adults between 2005-06 and 2013-14, covering the most recent recessionary period and recovery. DESIGN: Means were compared across survey rounds relative to 2005-06. Multivariate regression was used to account for changes in demographic characteristics over time. SETTING: National Health and Nutrition Examination Survey (NHANES), 2005-2014...
September 7, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28877728/we-need-support-a-delphi-study-about-desirable-support-during-the-first-year-in-the-emergency-medical-service
#12
Anna Hörberg, Maria Jirwe, Susanne Kalén, Veronica Vicente, Veronica Lindström
BACKGROUND: New and inexperienced emergency medical service (EMS) professionals lack important experience. To prevent medical errors and improve retention there is an urgent need to identify ways to support new professionals during their first year in the EMS. METHODS: A purposeful sample and snowball technique was used and generated a panel of 32 registered nurses with 12-48 months of EMS experience. A Delphi technique in four rounds was used. Telephone interviews were undertaken in round one to identify what desirable support professionals new to the EMS desire during their first year...
September 6, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28877619/-that-was-a-good-shift
#13
Anya Johnson, Helena Nguyen, Sharon K Parker, Markus Groth, Steven Coote, Lin Perry, Bruce Way
Purpose The purpose of this paper is to investigate a boundary spanning, interprofessional collaboration between advanced practice nurses (APNs) and junior doctors to support junior doctors' learning and improve patient management during the overtime shift. Design/methodology/approach A mixed methods evaluation of an intervention in an adult tertiary referral hospital, to enhance interprofessional collaboration on overtime shifts. Phase 1 compared tasks and ward rounds on 86 intervention shifts with 106 "regular" shifts, and examined the effect on junior doctor patient management testing a model using regression techniques...
June 19, 2017: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/28876478/achieving-consensus-on-principles-of-good-practice-for-school-health-in-independent-schools-a-delphi-study
#14
Miguel G Marshall, John P Allegrante
BACKGROUND: Although the 8 components of the coordinated school health (CSH) framework have been implemented to various degrees in the nation's public schools, principles of good practice (PGPs) to guide health promotion efforts in independent schools do not exist. The purpose of this study was to generate PGPs and rate their feasibility of implementation. METHODS: A modified Delphi process was used to generate PGPs for school health in independent schools and develop consensus regarding their feasibility of implementation...
October 2017: Journal of School Health
https://www.readbyqxmd.com/read/28875359/volatile-chemical-emission-as-a-weapon-of-rearguard-action-a-game-theoretic-model-of-contest-behavior
#15
Mike Mesterton-Gibbons, Yao Dai, Marlène Goubault, Ian C W Hardy
We use a game-theoretic model to explore whether volatile chemical (spiroacetal) emissions can serve as a weapon of rearguard action. Our basic model explores whether such emissions serve as a means of temporary withdrawal, preventing the winner of the current round of a contest from translating its victory into permanent possession of a contested resource. A variant of this model explores an alternative possibility, namely, that such emissions serve as a means of permanent retreat, attempting to prevent a winner from inflicting costs on a fleeing loser...
September 5, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28873784/development-of-national-guidelines-for-the-ground-rules-to-lending-assistive-technology-devices-in-finland
#16
Anne Kanto-Ronkanen, Markku Hupli, Hanna Nyfors
Central Hospital Districts (CHD) in Finland provide most of the Assistive Technology Device Services (ATDS). ATDSs have been developing their work and unifying their practices regionally. Each of these 20 CHDs have their own guidelines for the ground rules for lending assistive technology devices. These ground rules include principles of ATD Services and lending rules for different device groups classified by ISO 9999 standard. There has been a growing pressure to unify the practices of ATDS nationally, because of a growing need for devices and economy...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28872620/electron-beam-welding-of-in792-ds-effects-of-pass-speed-and-pwht-on-microstructure-and-hardness
#17
Giuliano Angella, Giuseppe Barbieri, Riccardo Donnini, Roberto Montanari, Maria Richetta, Alessandra Varone
Electron Beam (EB) welding has been used to realize seams on 2 mm-thick plates of directionally solidified (DS) IN792 superalloy. The first part of this work evidenced the importance of pre-heating the workpiece to avoid the formation of long cracks in the seam. The comparison of different pre-heating temperatures (PHT) and pass speeds (v) allowed the identification of optimal process parameters, namely PHT = 300 °C and v = 2.5 m/min. The microstructural features of the melted zone (MZ); the heat affected zone (HAZ), and base material (BM) were investigated by optical microscopy (OM), scanning electron microscopy (SEM), energy dispersion spectroscopy (EDS), electron back-scattered diffraction (EBSD), X-ray diffraction (XRD), and micro-hardness tests...
September 5, 2017: Materials
https://www.readbyqxmd.com/read/28870259/rdfio-extending-semantic-mediawiki-for-interoperable-biomedical-data-management
#18
Samuel Lampa, Egon Willighagen, Pekka Kohonen, Ali King, Denny Vrandečić, Roland Grafström, Ola Spjuth
BACKGROUND: Biological sciences are characterised not only by an increasing amount but also the extreme complexity of its data. This stresses the need for efficient ways of integrating these data in a coherent description of biological systems. In many cases, biological data needs organization before integration. This is not seldom a collaborative effort, and it is thus important that tools for data integration support a collaborative way of working. Wiki systems with support for structured semantic data authoring, such as Semantic MediaWiki, provide a powerful solution for collaborative editing of data combined with machine-readability, so that data can be handled in an automated fashion in any downstream analyses...
September 4, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28869639/analysis-of-the-influence-of-the-transducer-and-its-coupling-layer-on-round-window-stimulation
#19
Houguang Liu, Dan Xu, Jianhua Yang, Shanguo Yang, Gang Cheng, Xinsheng Huang
PURPOSE: In this work, a finite element study is proposed to evaluate the effects of the transducer and its coupling layer on the performance of round window (RW) stimulation. METHODS: Based on a set of micro-computer tomography images of a healthy adult's right ear and reverse engineering technique, a coupled finite-element model of the human ear and the transducer was constructed and verified. Then, the effect of the cross-section of the transducer, the elastic modulus of the coupling layer, the mass of the transducer, and the preload of the transducer were studied...
2017: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/28864437/organizational-factors-associated-with-perceived-quality-of-patient-care-in-closed-intensive-care-units
#20
Nathalie McIntosh, Eva Oppel, David Mohr, Mark Meterko
BACKGROUND: Improving patient care quality in intensive care units is increasingly important as intensive care unit services account for a growing proportion of hospital services. Organizational factors associated with quality of patient care in such units have been identified; however, most were examined in isolation, making it difficult to assess the relative importance of each. Furthermore, though most intensive care units now use a closed model, little research has been done in this specific context...
September 2017: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
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