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Elaine Cole
'In the past when my dad was in hospital, I had been made to feel like an intruder without a valid opinion,' says Geraldine Strohm. 'I was amazed to hear that I could get help with the extortionate parking costs. That small gesture meant so much to me, as all thoughts of personal care went out of the window while I was trying to help keep dad alive.'
May 24, 2017: Nursing Standard
Hirofumi Yasumuro, Keisuke Sakurai, Fubito Toyama, Fumiaki Maruo, Chikafumi Chiba
The newt is an amazing four-limbed vertebrate that can regenerate various body parts including the retina. In this animal, when the neural retina (NR) is removed from the eye by surgery (retinectomy), both the NR and the retinal pigment epithelium (RPE) eventually regenerate through the process of reprogramming and proliferation of RPE cells. Thus far, we have pursued the onset mechanism of adult newt retinal regeneration. In this study, using an in vitro system, we found that both mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK and β-catenin were involved in cell cycle re-entry of RPE cells...
May 20, 2017: Biomedicines
Wendy S Barclay
Working in an area such as influenza is a free ticket into science communication, a pathway aided amply by the amazing evolutionary powers of the virus; regular outbreaks keep the media engaged and the audience keen. Everyone has heard of flu, and they probably already have an opinion: 'I don't take the vaccine, it gives me the flu anyway.' 'Didn't the government waste loads of money on that Tamiflu drug that doesn't work?' 'I've never had flu because I eat a banana every day and sleep with a boiled onion when I've sat next to someone on the train who was coughing...
May 23, 2017: Journal of General Virology
Ezra Gabbay, Klemens B Meyer
No abstract text is available yet for this article.
June 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Robert M Sade
Alexis Carrel and Charles Lindbergh were among the most famous international figures in the 20th century: Carrel, the surgeon-scientist who won a Nobel prize as a young surgeon, and Lindbergh, the aviator-engineer who pioneered aviation and promoted commercial flight throughout his life. Surprisingly, these two amazing individuals came together to collaborate on the early development of extracorporeal circulation. Their work was interrupted by the onset of World War II, which destroyed one of them and nearly destroyed the other...
June 2017: Annals of Thoracic Surgery
Yiran Kang, Xiao-Xi Li, Kyung-Bin Cho, Wei Sun, Chungu Xia, Wonwoo Nam, Yong Wang
Although nonheme iron(III)-iodosylarene complexes present amazing oxidative efficiency and selectivity, the nature of such complexes and related oxidation mechanism are still unsolved after decades of experimental efforts. Density functional calculations were employed to explore the structure-reactivity relationship of the iron(III)-iodosylbenzene complex [FeIII(tpena(-))(PhIO)](2+) (1) in thioanisole sulfoxidation. Our theoretical work revealed that complex 1 can evolve to two resonance valence-bond electronic structures (a high-valent iron-oxo species and a monomeric PhIO species) in thioanisole sulfoxidation to present different reaction mechanisms (the novel bond-cleavage coupled electron transfer mechanism or the direct oxygen-atom transfer mechanism) as a response to different substrate attack orientations...
May 19, 2017: Journal of the American Chemical Society
Bin Wang, Tarah N Sullivan
Keratinous materials, omnipresent as the hard and durable epidermal appendages of animals, are one of the toughest biological materials. They exhibit diverse morphologies and structures that serve a variety of amazing and inspiring mechanical functions. In this work, we provide a review of representative terrestrial, aerial and aquatic keratinous materials, pangolin scales, feather shafts and baleen plates, and correlate their hierarchical structures to respective functions of dermal armor, flight material and undersea filter...
May 8, 2017: Journal of the Mechanical Behavior of Biomedical Materials
David J Callans
Mark Josephson is without a doubt the most fascinating person I have ever met. I am proud to have had a close friendship with him and I miss him immensely. I have written in the past about his amazing academic contributions, but in a way I am relieved that this is not my topic today. I will instead talk about the unique aspects of his personality that allowed him to be a great leader in the field of electrophysiology and a powerful influence on the personal development of those of us who had the great good fortune of interacting with him closely...
April 2017: Arrhythmia & Electrophysiology Review
Weiqiang Chen, Saikat Bhaumik, Sjoerd A Veldhuis, Guichuan Xing, Qiang Xu, Michael Grätzel, Subodh Mhaisalkar, Nripan Mathews, Tze Chien Sum
Multiphoton absorption processes enable many technologically important applications, such as in vivo imaging, photodynamic therapy and optical limiting, and so on. Specifically, higher-order nonlinear absorption such as five-photon absorption offers significant advantages of greater spatial confinement, increased penetration depth, reduced autofluorescence, enhanced sensitivity and improved resolution over lower orders in bioimaging. Organic chromophores and conventional semiconductor nanocrystals are leaders in two-/three-photon absorption applications, but face considerable challenges from their small five-photon action cross-sections...
May 12, 2017: Nature Communications
Morgane Plantier, Nathalie Havet, Thierry Durand, Nicolas Caquot, Camille Amaz, Pierre Biron, Irène Philip, Lionel Perrier
BACKGROUND: Electronic health records (EHR) are increasingly being adopted by healthcare systems worldwide. In France, the "Hôpital numérique 2012-2017" program was implemented as part of a strategic plan to modernize health information technology (HIT), including the promotion of widespread EHR use. With significant upfront investment costs as well as ongoing operational expenses, it is important to assess this system in terms of its ability to result in improvements in hospital performances...
June 2017: International Journal of Medical Informatics
Han Wu, Yu-Qi Zhang, Min-Biao Hu, Li-Jun Ren, Yue Lin, Wei Wang
Clusters are an important class of nanoscale molecules or superatoms that exhibit an amazing diversity in structure, chemical composition, shape, and functionality. Assembling two types of clusters is creating emerging cluster-assembled materials (CAMs). In this paper, we report an effective approach to produce quasi two-dimensional (2D) CAMs of two types of spherelike clusters, polyhedral oligomeric silsesquioxanes (POSS), and polyoxometalates (POM). To avoid macrophase separation between the two clusters, they are covalently linked to form a POM-POSS cocluster with Janus characteristics and a dumbbell shape...
May 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Savita Devi, Naveen Kumar, Suman Kapila, Sanusi Bello Mada, Srinu Reddi, Rishika Vij, Rajeev Kapila
Oxidative stress is one of a critical pathogenic factor in the progression of aging and chronic diseases such as cancer, myocardial inflammation and diabetes. In the present scenario, peptides with short half life and more biological specificities are gaining much attention as prodrugs. Thus, the present investigation carried out to screen potential antioxidative peptide, VLPVPQK to cope with the cellular oxidative damage. Our results showed that treatment of rat fibroblast cells with 0.2mM H2O2 for 6h significantly declined different oxidative stress biomarkers such as SOD, CAT, GSH, and promoted LDH activity...
May 5, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
Yi Yang, Lingli Li, Litai Ma, Junfeng Zeng, Tingkui Wu, Hao Liu
RATIONALE: The zero-profile, standalone device (Zero-P, Synthes GmbH, Switzerland) has been reported to be an effective and safe treatment method with similar clinical outcomes compared with plate. Instrumental complications concerning Zero-P have been little reported. Considering the rarity, we present this amazing case to share with our spinal surgeons and instrument specialists. PATIENT CONCERNS: A 46-year-old man patient presented to our hospital with neck and shoulders pain for 23 years, numbness and weak-ness of right hand for 6 months...
May 2017: Medicine (Baltimore)
Maria Antonietta Zoroddu, Serenella Medici, Massimiliano Peana, Valeria Marina Nurchi, Joanna I Lachowicz, Max Costa
Tungsten or wolfram was regarded for many years as an enemy within the tin smelting and mining industry, because it conferred impurity or dirtiness in tin mining. However, later it was considered an amazing metal for its strength and flexibility, together with its diamond like hardness and its melting point which is the highest of any metal. It was first believed to be relatively inert and an only slightly toxic metal, beginning in the year 2000, the risk exerted by tungsten alloys, its dusts and particulates to induce cancer and several other adverse effects in animals as well as humans has been highlighted from in vitro and in vivo experiments...
April 27, 2017: Current Medicinal Chemistry
Samson O Obado, Mark C Field, Michael P Rout
The core architecture of the eukaryotic cell was established well over one billion years ago, and is largely retained in all extant lineages. However, eukaryotic cells also possess lineage-specific features, frequently keyed to specific functional requirements. One quintessential core eukaryotic structure is the nuclear pore complex (NPC), responsible for regulating exchange of macromolecules between the nucleus and cytoplasm as well as acting as a nuclear organizational hub. NPC architecture has been best documented in one eukaryotic supergroup, the Opisthokonts (e...
May 2, 2017: Nucleus
Daniel J Little, Dillon O Edwards, Milton R Smith, Thomas W Hamann
The electrolysis of ammonia (NH3), a potential carrier for hydrogen fuel, has only been studied in detail in systems employing expensive, noble metal anodes such as platinum, ruthenium, and iridium. For NH3 to serve as a practical hydrogen storage medium, the electrolysis process must be energy efficient, scalable, and inexpensive. Clearly, alternatives to precious metals would greatly reduce costs if the performance of less expensive, more abundant metals rivaled those of their expensive counterparts. In this regard, no metal is less expensive than iron...
May 3, 2017: ACS Applied Materials & Interfaces
Qingqing Li, Zhen Huang, Pengfei Guan, Rui Su, Qi Cao, Yimin Chao, Wei Shen, Junjie Guo, Hualong Xu, Renchao Che
Oxide materials with redox capability have attracted worldwide attentions in many applications. Introducing defects into crystal lattice is an effective method to modify and optimize redox capability of oxides as well as their catalytic performance. However, the relationship between intrinsic characteristics of defects and properties of oxides has been rarely reported. Herein, we report a facile strategy to introduce defects by doping a small amount of Ni atoms (∼1.8 at. %) into ceria lattice at atomic level through the effect of microstructure of crystal on the redox property of ceria...
May 3, 2017: ACS Applied Materials & Interfaces
Lisa M Fischer
No abstract text is available yet for this article.
May 2017: Annals of Emergency Medicine
Yongquan Qing, Chuanbo Hu, Chuanning Yang, Kai An, Fawei Tang, Junyang Tan, Changsheng Liu
Superhydrophobic surfaces with self-cleaning properties have been developed based on roughness on the micro- and nanometer scales and low-energy surfaces. However, such surfaces are fragile and stop functioning when exposed to oil. Addressing these challenges, here we show an ultrarobust self-cleaning surface fabricated by a process of metal electrodeposition of a rough structure that is subsequently coated with fluorinated metal-oxide nanoparticles. Scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, and X-ray diffraction were employed to characterize the surfaces...
May 2, 2017: ACS Applied Materials & Interfaces
Tian-Jia Jiang, Meng Yang, Shan-Shan Li, Ming-Jun Ma, Nan-Jing Zhao, Zheng Guo, Jin-Huai Liu, Xing-Jiu Huang
Traditional laser-induced breakdown spectroscopy (LIBS) always fails to directly detect target in aqueous solution due to rapid quenching of emitted light and adsorption of pulse energy by surrounding water. A method is proposed for the in situ underwater LIBS analysis of Cr(VI) in aqueous solution freed from the common problems mentioned above by combining a gas-assisted localized liquid discharge apparatus with electrosorption for the first time. In this approach, the introduction of the gas-assisted localized liquid discharge apparatus provides an instantaneous gaseous environment for underwater LIBS measurement (that is, the transfer of sampling matrix is not needed from aqueous solution to dry state)...
April 24, 2017: Analytical Chemistry
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