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Moaziz Sarfaraz, Rana Hasan Syeda
Levetiracetam and topiramate are newer anticonvulsants, which is why international data on overdoses of these drugs are lacking. Only a few mild adverse reactions have been noted. These anticonvulsants have been the drug of choice for neurologists. Despite their wide usage, there is a dearth of literature on symptoms and signs of their toxicity. Presented here is the case of a 21-year-old female who overdosed twice on levetiracetam and topiramate. The woman was admitted and discharged after the first overdose...
March 19, 2017: Drug Discoveries & Therapeutics
Wade R Roberts, Eric H Roalson
BACKGROUND: Flowers have an amazingly diverse display of colors and shapes, and these characteristics often vary significantly among closely related species. The evolution of diverse floral form can be thought of as an adaptive response to pollination and reproduction, but it can also be seen through the lens of morphological and developmental constraints. To explore these interactions, we use RNA-seq across species and development to investigate gene expression and sequence evolution as they relate to the evolution of the diverse flowers in a group of Neotropical plants native to Mexico-magic flowers (Achimenes, Gesneriaceae)...
March 20, 2017: BMC Genomics
Peter J Schwartz, Gaetano M De Ferrari, Luigi Pugliese
One hundred years have elapsed since Thomas Jonnesco performed the first left cardiac sympathetic denervation (LCSD) in a patient with unmanageable angina pectoris and ventricular tachyarrhythmias, and the progress in the field has surpassed imagination. Here we will review the historic basis of cardiac sympathectomy for the management of life-threatening arrhythmias and will then discuss the often forgotten critical experimental studies that provided the rationale for the amazing growth of its role in clinical management...
March 8, 2017: International Journal of Cardiology
Y Yang, G Ferreira, C L Teets, B A Corl, W E Thomason, C A Griffey
The objectives of this study were to evaluate production performance, milk fatty acid composition, and nutrient digestibility in high-producing dairy cows consuming diets containing corn and hull-less barley (cultivar Amaze 10) in different proportions as the grain source. Eight primiparous and 16 multiparous Holstein cows were assigned to 1 of 4 diets in a replicated 4 × 4 Latin square design with 21-d periods. Cows were fed once daily (1200 h) by means of a Calan gate system (American Calan Inc., Northwood, NH)...
March 16, 2017: Journal of Dairy Science
Gillian Murphy
To many of us in the field, working on Matrix Metalloproteinases (MMPs) has felt like riding a roller coaster, traveling through times of both excitement and despair. I was fortunate to join the ride when it was a mere carousel of three activities thought to target the proteins that comprise the extracellular matrix (ECM). New technologies brought the thrills of discovery, as we uncovered specific proteinase genes and defined specialised activities in different cellular processes. The MMPs and the sister families of 'A Disintegrin And Metalloproteinase' (ADAMs), ADAMs with ThromboSpondin domains (ADAM-TS) and Astacins are now recognised as key signalling 'scissors' that drive rapid changes in a plethora of cellular pathways...
March 15, 2017: Journal of Biological Chemistry
(no author information available yet)
Ten years ago, at the age of 40, I had a major stroke and lost my old life overnight. During my stay in hospital I was abused by healthcare staff.
March 15, 2017: Nursing Standard
Sergio Sánchez, Arnold L Demain
No abstract text is available yet for this article.
March 10, 2017: Biochemical Pharmacology
Hao Wang, Qiming Feng, Kun Liu, Zishun Li, Xuekun Tang, Guangze Li
A direct alkali-hydrothermal induced transformation process was adopted to prepare nepheline from raw kaolinite (shortened form RK in this paper) and NaOH solution in this paper. Structure and morphology characterizations of the synthetic product showed that the nepheline possessed high degree of crystallinity and uniform surface morphology. Specific surface area of nepheline is 18 m(2)/g, with a point of zero charge at around pH 5.0-5.5. The fluoride (F(-) ions) adsorption by the synthetic nepheline (shortened form SN in this paper) from aqueous solution was also investigated under different experimental conditions...
March 8, 2017: Journal of Environmental Management
Neelam Lohani, Rajeswari Raja Moganty
HMGB1 (High Mobility Group Box-1) is a very versatile highly abundant architectural protein that plays multiple roles in human health and diseases. Under physiological condition it serves an amazing assortment of roles in different compartments of cell. The reported high expression of HMGB1 in almost all types of human cancers and inflammatory diseases make it a critical molecular therapeutic target. In the present study we have mobilized a proximal twenty one bp nucleotide (21RY) which is in the promoter region (-55 to-75) of hmgb1 gene and targeted it with triplex forming oligonucleotide (TFO) in combination with two widely used chemotherapeutic drugs actinomycin (ACT) and adriamycin (ADM)...
February 13, 2017: Anti-cancer Agents in Medicinal Chemistry
Anurag Joshi, Ravi Kiran, Ash Narayan Sah
BACKGROUND: This paper studies the impact of musical religious songs (hymns) for managing stress of Indian Engineering students through Galvanic Skin Response (GSR). OBJECTIVE: The objective of the paper is to find out, whether listening to hymns is able to reduce the value of GSR. METHODS: Sample students were selected through initial screening and the students who reported high mental stress during the interview were selected for the main drills...
February 27, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
Sameer B Shah
Nerves in the mouth of the rorqual whale can double in length during feeding, without incurring damage. Several clever structural features underlie this amazing phenomenon. Such neuroprotective architectural strategies may be conserved, to a lesser extreme, across the organismal spectrum.
March 6, 2017: Current Biology: CB
Weiguang Ran, Lili Wang, Hongwei Xu, Xiaoying Kong, Yuwei Sun, Dan Qu, Jinsheng Shi
Zn2SiO4, Zn2GeO4, and CdAl2O4 possess high electron density in their six-membered-ring nanotunnels, manganese from MnO2 was successfully doped into them, and green or blue phosphors were produced in air. It is nanotunnel A with high electron density that induces active sites for the reduction of Mn(IV). Mn(IV) is captured and reduced to Mn(II) on active sites by seizing two electrons from native defect VO(×) (VO(×) + Mn(4+) → VO(··) + Mn(2+)). CdB4O7:0.02Mn(2+) was also synthesized from MnO2 or MnCO3 to confirm the role of nanotunnels...
March 7, 2017: Inorganic Chemistry
Anabela Ferro, Tânia Mestre, Patrícia Carneiro, Ivan Sahumbaiev, Raquel Seruca, João M Sanches
In the past decades, there has been an amazing progress in the understanding of the molecular mechanisms of the cell cycle. This has been possible largely due to a better conceptualization of the cycle itself, but also as a consequence of technological advances. Herein, we propose a new fluorescence image-based framework targeted at the identification and segmentation of stained nuclei with the purpose to determine DNA content in distinct cell cycle stages. The method is based on discriminative features, such as total intensity and area, retrieved from in situ stained nuclei by fluorescence microscopy, allowing the determination of the cell cycle phase of both single and sub-population of cells...
March 6, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
Igor Rudez
It was in the mid-nineties when a senior colleague of mine, Dr. Bojan Biocina, introduced me to something called "OpenHeart-L" on The Heart Surgery Forum website. Suddenly, a whole new world appeared in front of me! The possibility to communicate with colleagues from all around the globe was amazing. And not only that-one could ask anything, and there was always someone who had an answer, gave a piece of advice…what to do, what to was magic! The person responsible for this whole idea of sharing information and interactive communication was Mark Levinson...
February 24, 2017: Heart Surgery Forum
Katherine V Bankaitis
After a lifetime's work devoted to metastasis research, Dr. Sue Eccles recently retired. She was a founding member the Metastasis Research Society in 1984, and has served as Editor-In-Chief of Clinical and Experimental Metastasis from its inception until her retirement, an amazing 32 years of service. Dr. Kate Bakaitis recently talked with Dr. Eccles about her experiences, memories and advice for young investigators.
March 4, 2017: Clinical & Experimental Metastasis
Andrea Nevedal, Stewart Neufeld, Mark Luborsky, Andrea Sankar
This paper reports findings from a study that compared older (n = 21, ≥ age 50) and younger (n = 96, ≤ age 49) African Americans' stories (N = 117) of living with HIV/AIDS to determine how they make sense of the experience. The purpose was to: (1) identify and describe the cultural models African Americans use to inform their stories of living with HIV/AIDS, and (2) to compare older and younger adults' HIV stories. To characterize the cultural models engaged in the telling of these HIV stories, we conducted schema analysis...
March 3, 2017: Journal of Cross-cultural Gerontology
Cheng-Han Wu, Yu-Jen Chen, Mu-Hui Wang, Ling-Ling Chiou, Wen-Yih Isaac Tseng, Hsuan-Shu Lee
Axolotls have amazing ability to regenerate their lost limbs. Our previous works showed that after amputation the remnant muscle ends remained at their original location whilst sending satellite cells into the regenerating parts to develop into early muscle fibers in the late differentiation stage. The parental and the newly formed muscle fibers were not connected until very late stage. The present study used non-invasive diffusion tensor imaging (DTI) to monitor weekly axolotl upper arm muscles after amputation of their upper arms...
2017: PloS One
Chun Cao, Liling Wei, Gang Wang, Jianquan Shen
The exploration of highly active and cost-effective catalysts for the oxygen reduction reaction is vitally important to facilitate the improvement of metal-air batteries and fuel cells. Herein, super-active catalysts made from an interesting metal-polymer network (MPN) that consist of Fe-Nx-C, B-N and Fe3O4/Fe3C alloys were prepared via facile one-pot carbonization. The achieved catalysts possessed an amazing porous structure that was derived from the MPN with the assistance of a "bubble-template". Remarkably, the content of highly active Fe-Nx-C can be regulated by introducing graphene, and the ORR activity of the catalyst was enhanced dramatically with an increase in the Fe3O4/Fe3C alloy content...
February 28, 2017: Nanoscale
Thierry Moreno
Third-generation storage rings are massively evolving due to the very compact nature of the multi-bend achromat (MBA) lattice which allows amazing decreases of the horizontal electron beam emittance, but leaves very little place for infrared (IR) extraction mirrors to be placed, thus prohibiting traditional IR beamlines. In order to circumvent this apparent restriction, an optimized optical layout directly integrated inside a SOLEIL synchrotron dipole chamber that delivers intense and almost aberration-free beams in the near- to mid-IR domain (1-30 µm) is proposed and analyzed, and which can be integrated into space-restricted MBA rings...
March 1, 2017: Journal of Synchrotron Radiation
Achim Guckenberger, Stephan Gekle
Cell membranes are vital to shield a cell's interior from the environment. At the same time they determine to a large extent the cell's mechanical resistance to external forces. In recent years there has been considerable interest in the accurate computational modeling of such membranes, driven mainly by the amazing variety of shapes that red blood cells and model systems such as vesicles can assume in external flows. Given that the typical height of a membrane is only a few nanometers while the surface of the cell extends over many micrometers, physical modeling approaches mostly consider the interface as a two-dimensional elastic continuum...
February 27, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
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