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https://www.readbyqxmd.com/read/28079027/the-properties-of-ultrapure-delafossite-metals
#1
A P Mackenzie
Although they were first synthesized in chemistry laboratories nearly fifty years ago, the physical properties of the metals PdCoO2, PtCoO2 and PdCrO2 have only more recently been studied in detail. The delafossite structure contains triangular co-ordinated atomic layers, and electrical transport in the delafossite metals is strongly 2D. Their most notable feature is their in-plane conductivity, which is amazingly high for oxide metals. At room temperature, the conductivity of non-magnetic PdCoO2 and PtCoO2 is higher per carrier than those of any alkali metal and even the most conductive elements, copper and silver...
January 12, 2017: Reports on Progress in Physics
https://www.readbyqxmd.com/read/28074876/scale-up-of-nature-s-tissue-weaving-algorithms-to-engineer-advanced-functional-materials
#2
Joanna L Ng, Lillian E Knothe, Renee M Whan, Ulf Knothe, Melissa L Knothe Tate
We are literally the stuff from which our tissue fabrics and their fibers are woven and spun. The arrangement of collagen, elastin and other structural proteins in space and time embodies our tissues and organs with amazing resilience and multifunctional smart properties. For example, the periosteum, a soft tissue sleeve that envelops all nonarticular bony surfaces of the body, comprises an inherently "smart" material that gives hard bones added strength under high impact loads. Yet a paucity of scalable bottom-up approaches stymies the harnessing of smart tissues' biological, mechanical and organizational detail to create advanced functional materials...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28069354/bufadienolides-from-amphibians-a-promising-source-of-anticancer-prototypes-for-radical-innovation-apoptosis-triggering-and-na-k-atpase-inhibition
#3
REVIEW
Lívia Queiroz de Sousa, Kátia da Conceição Machado, Samara Ferreira de Carvalho Oliveira, Lidiane da Silva Araújo, Evaldo Dos Santos Monção-Filho, Ana Amélia de Carvalho Melo-Cavalcante, Gerardo Magela Vieira-Júnior, Paulo Michel Pinheiro Ferreira
Amphibians present pharmacologically active aliphatic, aromatic and heterocyclic molecules in their skin as defense against microorganisms, predators and infections, such as steroids, alkaloids, biogenic amines, guanidine derivatives, proteins and peptides. Based on the discovered bioactive potential of bufadienolides, this work reviewed the contribution of amphibians, especially from members of Bufonidae family, as source of new cytotoxic and antitumor molecules, highlighting the mechanisms responsible for such amazing biological potentialities...
January 6, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28067063/screening-based-approaches-to-identify-small-molecules-that-inhibit-protein-protein-interactions
#4
Sehee Choi, Kang-Yell Choi
Protein-protein interactions (PPIs) are very attractive targets for drug development as they play important roles in regulating many aspects of pathophysiologies. It has recently been revealed that the functionally important region of most PPIs is small enough to be modulated by small molecules. Thus, many studies in this field have achieved amazing progress, together with diverse and advanced screening technologies. Areas covered: This article presents screening technologies to identify small molecule inhibitors of PPIs in addition to discussing the suitability of PPIs as molecular targets...
January 8, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28065782/4-hydroxynonenal-metabolites-and-adducts-in-pre-carcinogenic-conditions-and-cancer
#5
REVIEW
Françoise Guéraud
4-hydroxy-2-nonenal (HNE) is an amazing reactive compound, originating from lipid peroxidation within cells but also in food and considered as a "second messenger" of oxidative stress. Due to its chemical features, HNE is able to make covalent links with DNA, proteins and lipids. The aim of this review is to give a comprehensive summary of the chemical properties of HNE and of the consequences of its reactivity in relation to cancer development. The formation of exocyclic etheno-and propano-adducts and genotoxic effects are addressed...
January 5, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28048283/we-h-204-03-part-2-history-and-archives-resources-at-aip-for-aapm-and-its-members
#6
M Mueller
: "William D. Coolidge, Inventor of the Modern X-ray Tube" David J. Allard, M.S., CHP - Director, PA DEP Bureau of Radiation Protection William David Coolidge 1873-1975 was a research scientist and inventor of the modern X-ray tube. Besides Roentgen, with his 1895 discovery and subsequent studies of X-rays, perhaps no other individual contributed more to the advancement of X-ray technology than did Coolidge. He was born in Hudson, MA and received his Bachelor of Science degree from MIT in 1896...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047523/we-h-204-00-history-committee-symposium
#7
Michael Gossman
: "William D. Coolidge, Inventor of the Modern X-ray Tube" David J. Allard, M.S., CHP - Director, PA DEP Bureau of Radiation Protection William David Coolidge 1873-1975 was a research scientist and inventor of the modern X-ray tube. Besides Roentgen, with his 1895 discovery and subsequent studies of X-rays, perhaps no other individual contributed more to the advancement of X-ray technology than did Coolidge. He was born in Hudson, MA and received his Bachelor of Science degree from MIT in 1896...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046866/we-h-204-01-william-d-coolidge-inventor-of-the-modern-x-ray-tube
#8
D Allard
: "William D. Coolidge, Inventor of the Modern X-ray Tube" David J. Allard, M.S., CHP - Director, PA DEP Bureau of Radiation Protection William David Coolidge 1873-1975 was a research scientist and inventor of the modern X-ray tube. Besides Roentgen, with his 1895 discovery and subsequent studies of X-rays, perhaps no other individual contributed more to the advancement of X-ray technology than did Coolidge. He was born in Hudson, MA and received his Bachelor of Science degree from MIT in 1896...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046206/we-h-204-02-part-1-history-and-archives-resources-at-aip-for-aapm-and-its-members
#9
G Good
: "William D. Coolidge, Inventor of the Modern X-ray Tube" David J. Allard, M.S., CHP - Director, PA DEP Bureau of Radiation Protection William David Coolidge 1873-1975 was a research scientist and inventor of the modern X-ray tube. Besides Roentgen, with his 1895 discovery and subsequent studies of X-rays, perhaps no other individual contributed more to the advancement of X-ray technology than did Coolidge. He was born in Hudson, MA and received his Bachelor of Science degree from MIT in 1896...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28034412/does-adoption-of-electronic-health-records-improve-organizational-performances-of-hospital-surgical-units-results-from-the-french-e-si-preps-sips-study
#10
Morgane Plantier, Nathalie Havet, Thierry Durand, Nicolas Caquot, Camille Amaz, Irène Philip, Pierre Biron, Lionel Perrier
BACKGROUND: Electronic health records (EHR) are increasingly being adopted by healthcare systems worldwide. In France, the "Hôpital numérique 2012-2017" program was implemented as part of a strategic plan to modernize health information technology (HIT), including promotion of widespread EHR use. With significant upfront investment costs as well as ongoing operational expenses, it is important to assess this system in terms of its ability to result in improvements in hospital performances...
February 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28028843/epitaxial-growth-and-air-stability-of-monolayer-antimonene-on-pdte2
#11
Xu Wu, Yan Shao, Hang Liu, Zili Feng, Ye-Liang Wang, Jia-Tao Sun, Chen Liu, Jia-Ou Wang, Zhong-Liu Liu, Shi-Yu Zhu, Yu-Qi Wang, Shi-Xuan Du, You-Guo Shi, Kurash Ibrahim, Hong-Jun Gao
Monolayer antimonene is fabricated on PdTe2 by an epitaxial method. Monolayer antimonene is theoretically predicted to have a large bandgap for nanoelectronic devices. Air-exposure experiments indicate amazing chemical stability, which is great for device fabrication. A method to fabricate high-quality monolayer antimonene with several great properties for novel electronic and optoelectronic applications is provided.
December 28, 2016: Advanced Materials
https://www.readbyqxmd.com/read/28026067/fuel-free-synthetic-micro-nanomachines
#12
Tailin Xu, Wei Gao, Li-Ping Xu, Xueji Zhang, Shutao Wang
Inspired by the swimming of natural microorganisms, synthetic micro-/nanomachines, which convert energy into movement, are able to mimic the function of these amazing natural systems and help humanity by completing environmental and biological tasks. While offering autonomous propulsion, conventional micro-/nanomachines usually rely on the decomposition of external chemical fuels (e.g., H2 O2 ), which greatly hinders their applications in biologically relevant media. Recent developments have resulted in various micro-/nanomotors that can be powered by biocompatible fuels...
December 27, 2016: Advanced Materials
https://www.readbyqxmd.com/read/28018651/stability-in-skipping-gaits
#13
Emanuel Andrada, Roy Müller, Reinhard Blickhan
As an alternative to walking and running, humans are able to skip. However, adult humans avoid it. This fact seems to be related to the higher energetic costs associated with skipping. Still, children, some birds, lemurs and lizards use skipping gaits during daily locomotion. We combined experimental data on humans with numerical simulations to test whether stability and robustness motivate this choice. Parameters for modelling were obtained from 10 male subjects. They locomoted using unilateral skipping along a 12 m runway...
November 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/28009453/reassigning-stop-codons-via-translation-termination-how-a-few-eukaryotes-broke-the-dogma
#14
Elena Alkalaeva, Tatiana Mikhailova
The genetic code determines how amino acids are encoded within mRNA. It is universal among the vast majority of organisms, although several exceptions are known. Variant genetic codes are found in ciliates, mitochondria, and numerous other organisms. All revealed genetic codes (standard and variant) have at least one codon encoding a translation stop signal. However, recently two new genetic codes with a reassignment of all three stop codons were revealed in studies examining the protozoa transcriptomes. Here, we discuss this finding and the recent studies of variant genetic codes in eukaryotes...
December 23, 2016: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/27994124/major-evolutionary-transitions-and-innovations-the-tympanic-middle-ear
#15
REVIEW
Abigail S Tucker
One of the most amazing transitions and innovations during the evolution of mammals was the formation of a novel jaw joint and the incorporation of the original jaw joint into the middle ear to create the unique mammalian three bone/ossicle ear. In this review, we look at the key steps that led to this change and other unusual features of the middle ear and how developmental biology has been providing an understanding of the mechanisms involved. This starts with an overview of the tympanic (air-filled) middle ear, and how the ear drum (tympanic membrane) and the cavity itself form during development in amniotes...
February 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27988439/biomechanical-characterization-of-spider-webs
#16
Rakesh Das, Amit Kumar, Anurag Patel, Sahil Vijay, Shashank Saurabh, Navin Kumar
In light of recent focus on the behaviour of the natural structures for revolutionary technological growth, spider web seems to have seized considerable attention of product designer due to its amazing behaviour. In present work, mechanism behind the structural integrity of the spider web along with the materialistic analysis of its constituent silk threads has been extensively investigated. The nanoindentation tool both in static and dynamic mode has been utilized for complete analysis of the mechanical behaviour of the spiral and radial threads separately...
December 13, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27986547/the-evolutionary-origin-of-diversity-in-chagas-disease-vectors
#17
REVIEW
Silvia A Justi, Cleber Galvão
Chagas disease is amongst the ten most important neglected tropical diseases but knowledge on the diversification of its vectors, Triatominae (Hemiptera: Reduviidae), is very scarce. Most Triatominae species occur in the Americas, and are all considered potential vectors. Despite its amazing ecological vignette, there are remarkably few evolutionary studies of the whole subfamily, and only one genome sequence has been published. The young age of the subfamily, coupled with the high number of independent lineages, are intriguing, yet the lack of genome-wide data makes it a challenge to infer the phylogenetic relationships within Triatominae...
January 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/27984578/natural-products-mapping-an-amazing-thicket
#18
Mark E Horsman, Christopher N Boddy
No abstract text is available yet for this article.
December 16, 2016: Nature Chemical Biology
https://www.readbyqxmd.com/read/27978923/-current-status-of-the-treatment-of-drug-induced-liver-injury
#19
H Zhao, W Xie
In recent years, with the amazing increase in the number of prescription drugs and non-prescription drugs and the irrational use of Chinese herbal medicine and healthcare products, the incidence of drug-induced liver injury (DILI) has been increasing year by year; however, there is still a lack of effective therapeutic methods for DILI at present. Standard treatment based on timely diagnosis should be emphasized, and it is necessary to fully evaluate the severity of liver injury and primary disease, withdraw suspected drugs in time, and select appropriate drugs...
November 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/27976732/biological-characteristics-comparison-of-hbv-rta181t-mutants-with-truncated-or-substituted-hbsag-expression-in-vitro-and-in-vivo-model-systems
#20
Ling-Yun Zhou, En-Qiang Chen, Meng-Lan Wang, Lan-Lan Chen, Cui-Ping Liu, Fan Zeng, Hong Tang
The hepatitis B virus(HBV) polymerase rtA181T mutation is selected during long-term antiviral therapy. As the polymerase gene completely overlaps with the envelope (S) gene, HBV rtA181T mutation also carries sW172 mutations. In this study, we investigated whether there were biological differences between rtA181T/sW172* (coding truncated HBsAg) and rtA181T/sW172L (coding substituted HBsAg) mutants. In cell experiments, a slight decline of viral replication was observed in both two mutants as compared to wild-type strains, but the levels of supernatant HBsAg and HBV DNA in rtA181T/sW172* were significantly lower than those in rtA181T/sW172L transfected cells...
December 15, 2016: Scientific Reports
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