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Tian-Jia Jiang, Meng Yang, Shan-Shan Li, Ming-Jun Ma, Nan-Jing Zhao, Zheng Guo, Jinhuai Liu, Xing-Jiu Huang
Traditional laser induced breakdown spectroscopy (LIBS) always fails to directly detect target in aqueous solution due to rapid quenching of emitted light and adsorption of pulse energy by surrounding water. A method is proposed for the in-situ underwater LIBS analysis of Cr(VI) in aqueous solution freed from the common problems mentioned above by combining gas-assisted localized liquid discharge apparatus with electrosorption for the first time. In this approach, the introduction of gas-assisted localized liquid discharge apparatus provides an instantaneous gaseous environment for underwater LIBS measurement (That is, the transfer of sampling matrix is not needed from aqueous solution to dry state)...
April 12, 2017: Analytical Chemistry
Kareem Salhiyyah, Ahmed Ashoub, Paul Diprose, Clifford Barlow
This text describe through images, how a knife is retrieved from the superior mediastinum.
April 2017: Annals of Cardiac Anaesthesia
Mariam Gaid, Eline Biedermann, Jendrik Füller, Paul Haas, Sönke Behrends, Rainer Krull, Stephan Scholl, Ute Wittstock, Christel Müller-Goymann, Ludger Beerhues
Hyperforin is a major active constituent of Hypericum perforatum (St. John's wort). It has amazing pharmacological activities, such as antidepressant properties, but it is labile and difficult to synthesize. Its sensitivity and lipophilicity are challenges for processing and formulation. Its chemical complexity provokes approaches of biotechnological production and modification. Dedifferentiated H. perforatum cell cultures lack appropriate storage sites and hence appreciable hyperforin levels. Shoot cultures are capable of forming hyperforin but less suitable for biomass up-scaling in bioreactors...
April 1, 2017: European Journal of Pharmaceutics and Biopharmaceutics
Minoru Takasato, Melissa H Little
An organoid can be defined as a three-dimensional organ-like structure formed from organ-specific progenitor cells. Organ progenitor cells were empirically found to self-organize three-dimensional tissues when they were aggregated and cultivated in vitro. While this nature power of progenitor cells has an amazing potential to recreate artificial organs in vitro, there had been difficulty to apply this technology to human organs due to the inaccessibility to human progenitor cells until human-induced pluripotent stem cell (hiPSC) was invented by Takahashi and Yamanaka in 2007...
2017: Methods in Molecular Biology
Lichun Peng, Pu Zhang, Yaqin Chai, Ruo Yuan
Herein, a dual microRNA (miRNA)-powered bi-directional DNA walking machine with precise control was developed to fabricate an enzyme-free biosensor on the basic of distance-based electrochemiluminescence (ECL) energy transfer for multiple detection of miRNAs. By using miRNA-21 as the driving force, the DNA walker could move forth along the track and generated quenching of ECL response due to the proximity between Au nanoparticles (AuNPs) and Mn2+ doped CdS nanocrystals (CdS:Mn NCs) film as the ECL emitters, realizing ultrasensitive determination of miRNA-21...
March 29, 2017: Analytical Chemistry
G M Maciel, R S Almeida, J P R da Rocha, V Andaló, G R Marquez, N C Santos, R R Finzi
The mini tomato production has expanded, becoming an amazing alternative for enterprise. Despite all commercial potential, the cultivation has the occurrence of pests as main obstacle during the crop development. Nowadays, there are no researches that aimed obtaining genotypes with high acylsugar content, capable of providing a broad-spectrum resistance to pests. This study aimed the selection of mini tomato genotypes, with high acylsugar content, and checking the resistance level to the silverleaf whitefly [Bemisia tabaci (Gennadius)] and to the two-spotted spider mites (Tetranychus urticae Koch)...
March 22, 2017: Genetics and Molecular Research: GMR
Moaziz Sarfaraz, Rana Hasan Syeda
Levetiracetam and topiramate are newer anticonvulsants, which is why international data on overdoses of these drugs are lacking. Only a few mild adverse reactions have been noted. These anticonvulsants have been the drug of choice for neurologists. Despite their wide usage, there is a dearth of literature on symptoms and signs of their toxicity. Presented here is the case of a 21-year-old female who overdosed twice on levetiracetam and topiramate. The woman was admitted and discharged after the first overdose...
March 19, 2017: Drug Discoveries & Therapeutics
Wade R Roberts, Eric H Roalson
BACKGROUND: Flowers have an amazingly diverse display of colors and shapes, and these characteristics often vary significantly among closely related species. The evolution of diverse floral form can be thought of as an adaptive response to pollination and reproduction, but it can also be seen through the lens of morphological and developmental constraints. To explore these interactions, we use RNA-seq across species and development to investigate gene expression and sequence evolution as they relate to the evolution of the diverse flowers in a group of Neotropical plants native to Mexico-magic flowers (Achimenes, Gesneriaceae)...
March 20, 2017: BMC Genomics
Peter J Schwartz, Gaetano M De Ferrari, Luigi Pugliese
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at
March 8, 2017: International Journal of Cardiology
Y Yang, G Ferreira, C L Teets, B A Corl, W E Thomason, C A Griffey
The objectives of this study were to evaluate production performance, milk fatty acid composition, and nutrient digestibility in high-producing dairy cows consuming diets containing corn and hull-less barley (cultivar Amaze 10) in different proportions as the grain source. Eight primiparous and 16 multiparous Holstein cows were assigned to 1 of 4 diets in a replicated 4 × 4 Latin square design with 21-d periods. Cows were fed once daily (1200 h) by means of a Calan gate system (American Calan Inc., Northwood, NH)...
May 2017: Journal of Dairy Science
Gillian Murphy
To many of us in the field, working on Matrix Metalloproteinases (MMPs) has felt like riding a roller coaster, traveling through times of both excitement and despair. I was fortunate to join the ride when it was a mere carousel of three activities thought to target the proteins that comprise the extracellular matrix (ECM). New technologies brought the thrills of discovery, as we uncovered specific proteinase genes and defined specialised activities in different cellular processes. The MMPs and the sister families of 'A Disintegrin And Metalloproteinase' (ADAMs), ADAMs with ThromboSpondin domains (ADAM-TS) and Astacins are now recognised as key signalling 'scissors' that drive rapid changes in a plethora of cellular pathways...
March 15, 2017: Journal of Biological Chemistry
(no author information available yet)
Ten years ago, at the age of 40, I had a major stroke and lost my old life overnight. During my stay in hospital I was abused by healthcare staff.
March 15, 2017: Nursing Standard
Sergio Sánchez, Arnold L Demain
No abstract text is available yet for this article.
March 10, 2017: Biochemical Pharmacology
Hao Wang, Qiming Feng, Kun Liu, Zishun Li, Xuekun Tang, Guangze Li
A direct alkali-hydrothermal induced transformation process was adopted to prepare nepheline from raw kaolinite (shortened form RK in this paper) and NaOH solution in this paper. Structure and morphology characterizations of the synthetic product showed that the nepheline possessed high degree of crystallinity and uniform surface morphology. Specific surface area of nepheline is 18 m(2)/g, with a point of zero charge at around pH 5.0-5.5. The fluoride (F(-) ions) adsorption by the synthetic nepheline (shortened form SN in this paper) from aqueous solution was also investigated under different experimental conditions...
March 8, 2017: Journal of Environmental Management
Neelam Lohani, Rajeswari Raja Moganty
HMGB1 (High Mobility Group Box-1) is a very versatile highly abundant architectural protein that plays multiple roles in human health and diseases. Under physiological condition it serves an amazing assortment of roles in different compartments of cell. The reported high expression of HMGB1 in almost all types of human cancers and inflammatory diseases make it a critical molecular therapeutic target. In the present study we have mobilized a proximal twenty one bp nucleotide (21RY) which is in the promoter region (-55 to-75) of hmgb1 gene and targeted it with triplex forming oligonucleotide (TFO) in combination with two widely used chemotherapeutic drugs actinomycin (ACT) and adriamycin (ADM)...
February 13, 2017: Anti-cancer Agents in Medicinal Chemistry
Anurag Joshi, Ravi Kiran, Ash Narayan Sah
BACKGROUND: This paper studies the impact of musical religious songs (hymns) for managing stress of Indian Engineering students through Galvanic Skin Response (GSR). OBJECTIVE: The objective of the paper is to find out, whether listening to hymns is able to reduce the value of GSR. METHODS: Sample students were selected through initial screening and the students who reported high mental stress during the interview were selected for the main drills...
February 27, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
Sameer B Shah
Nerves in the mouth of the rorqual whale can double in length during feeding, without incurring damage. Several clever structural features underlie this amazing phenomenon. Such neuroprotective architectural strategies may be conserved, to a lesser extreme, across the organismal spectrum.
March 6, 2017: Current Biology: CB
Weiguang Ran, Lili Wang, Hongwei Xu, Xiaoying Kong, Yuwei Sun, Dan Qu, Jinsheng Shi
Zn2SiO4, Zn2GeO4, and CdAl2O4 possess high electron density in their six-membered-ring nanotunnels, manganese from MnO2 was successfully doped into them, and green or blue phosphors were produced in air. It is nanotunnel A with high electron density that induces active sites for the reduction of Mn(IV). Mn(IV) is captured and reduced to Mn(II) on active sites by seizing two electrons from native defect VO(×) (VO(×) + Mn(4+) → VO(··) + Mn(2+)). CdB4O7:0.02Mn(2+) was also synthesized from MnO2 or MnCO3 to confirm the role of nanotunnels...
March 7, 2017: Inorganic Chemistry
Anabela Ferro, Tânia Mestre, Patrícia Carneiro, Ivan Sahumbaiev, Raquel Seruca, João M Sanches
In the past decades, there has been an amazing progress in the understanding of the molecular mechanisms of the cell cycle. This has been possible largely due to a better conceptualization of the cycle itself, but also as a consequence of technological advances. Herein, we propose a new fluorescence image-based framework targeted at the identification and segmentation of stained nuclei with the purpose to determine DNA content in distinct cell cycle stages. The method is based on discriminative features, such as total intensity and area, retrieved from in situ stained nuclei by fluorescence microscopy, allowing the determination of the cell cycle phase of both single and sub-population of cells...
March 6, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
Igor Rudez
It was in the mid-nineties when a senior colleague of mine, Dr. Bojan Biocina, introduced me to something called "OpenHeart-L" on The Heart Surgery Forum website. Suddenly, a whole new world appeared in front of me! The possibility to communicate with colleagues from all around the globe was amazing. And not only that-one could ask anything, and there was always someone who had an answer, gave a piece of advice…what to do, what to was magic! The person responsible for this whole idea of sharing information and interactive communication was Mark Levinson...
February 24, 2017: Heart Surgery Forum
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