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https://www.readbyqxmd.com/read/28222292/genomics-stentor-s-trumpet-sounds-anew
#1
Robert S Coyne
The amazing regenerative abilities of the giant ciliate Stentor coeruleus made it a favorite subject for classical embryologists. Now, its genome has been sequenced, enabling renewed experimental study and revealing unexpected surprises in mRNA splicing and the genetic code.
February 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28221040/magnetic-fullerene-dna-hyaluronic-acid-nanovehicles-with-magnetism-reduction-dual-responsive-triggered-release
#2
Ling Wang, Yitong Wang, Jingcheng Hao, Shuli Dong
We create the dual-responsive nanovehicle that can effectively combine and abundantly utilize magnetic and glutathione (GSH)-reductive triggers to control the drug delivery and achieve more intelligent and powerful targeting. In the nanovehicles, paramagnetic fullerene (C60@CTAF) was prepared via one-step modification of fullerene with magnetic surfactant CTAF by hydrophobic interaction for the first time. The perfect conjugation of C60 and CTAF increased the solubility or dispersity of fullerenes and qualify CTAF with more powerful assembly capability with DNA...
February 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28220454/the-remarkable-multivalency-of-the-hsp70-chaperones
#3
REVIEW
Erik R P Zuiderweg, Lawrence E Hightower, Jason E Gestwicki
Hsp70 proteins are key to maintaining intracellular protein homeostasis. To carry out this task, they employ a large number of cochaperones and adapter proteins. Here, we review what is known about the interaction between the chaperones and partners, with a strong slant toward structural biology. Hsp70s in general, and Hsc70 (HSPA8) in particular, display an amazing array of interfaces with their protein cofactors. We also review the known interactions between Hsp70s with lipids and with active compounds that may become leads toward Hsp70 modulation for treatment of a variety of diseases...
February 20, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28215087/microwave-initiated-facile-formation-of-ni3se4-nanoassemblies-for-enhanced-and-stable-water-splitting-in-neutral-and-alkaline-media
#4
Sengeni Anantharaj, Jeevarathinam Kennedy, Subrata Kundu
Molecular hydrogen (H2) generation through water splitting with minimum energy loss has become practically possible due to the recent evolution of high performance electrocatalysts. In this study, we had fabricated, evaluated and presented such a high performance catalyst which is the Ni3Se4 nanoassemblies that can efficiently catalyze water splitting in neutral and alkaline media. A hierarchical nanoassemblies of Ni3Se4 was fabricated by functionalizing the surface cleaned Ni foam using NaHSe solution as Se source with the assistance of microwave irradiation (300 W) for 3 min followed by 5 h of aging at room temperature (RT)...
February 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28214233/incorporation-of-arginine-mimetic-residue-into-peptides-for-recognition-of-double-stranded-nucleic-acid-structure-binding-and-aggregation-studies
#5
Mao Li, Marija Matković, Ivo Piantanida, Carsten Schmuck
An arginine mimetic, featuring a guanidiniocarbonypyrrol as artificial anion binding site (GCP), was introduced into short peptides to study their binding and aggregation with double stranded DNA and RNA. While the incorporation of this GCP modification did not significantly change the overall binding affinity for DNA/RNA, their interactions were more sensitive with respect to the type of polynucleotides. Peptide 4, with four GCP modifications, exhibited amazing fluorescent selectivity for AU- and (to a lesser extent) AT- sequences...
February 6, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28207255/supramolecular-complexation-of-carbon-nanostructures-by-crown-ethers
#6
Luis Moreira, Beatriz M Illescas, Nazario Martín
Since its discovery, crown ethers as well as the most recent carbon nanostructures, namely fullerenes, carbon nanotubes and graphene, have received a lot of attention from the chemical community. As a proof, these innovative chemical structures have gathered three Nobel Prizes in 1987, 1996 and 2010 corresponding to crown ethers, fullerenes and graphene, respectively. Merging these singular chemical structures has provided a wealth number of unprecedented supramolecular assemblies with new geometrical and electronic properties whose more representative examples have been presented in this synopsis organized according to the different nature of the carbon nanostructures...
February 16, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28195252/pathological-assessment-of-epilepsy-surgery-brain-tissue
#7
G Marucci, M Giulioni
Surgical resection represents a successful strategy to achieve seizure control in patients with drug resistant epilepsy. In the last years increasing importance has been recognized to pathological substrate for epilepsy classifications and for predicting seizure and neuropsychological outcome after surgery. The current histopathological classifications of epilepsy-associated abnormalities certainly represent an amazing effort to overcome the limits of the previous classifications and constitute a formidable tool in the management of patients after epilepsy surgery...
June 2016: Pathologica
https://www.readbyqxmd.com/read/28179913/potential-responses-of-vascular-plants-from-the-pristine-lost-world-of-the-neotropical-guayana-highlands-to-global-warming-review-and-new-perspectives
#8
REVIEW
Valentí Rull, Teresa Vegas-Vilarrúbia
The neotropical Guayana Highlands (GH) are one of the few remaining pristine environments on Earth, and they host amazing biodiversity with a high degree endemism, especially among vascular plants. Despite the lack of direct human disturbance, GH plants and their communities are threatened with extinction from habitat loss due to global warming (GW). Geographic information systems simulations involving the entire known vascular GH flora (>2430 species) predict potential GW-driven extinctions on the order of 80% by the end of this century, including nearly half of the endemic species...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28179395/molecular-physiology-of-freeze-tolerance-in-vertebrates
#9
REVIEW
Kenneth B Storey, Janet M Storey
Freeze tolerance is an amazing winter survival strategy used by various amphibians and reptiles living in seasonally cold environments. These animals may spend weeks or months with up to ∼65% of their total body water frozen as extracellular ice and no physiological vital signs, and yet after thawing they return to normal life within a few hours. Two main principles of animal freeze tolerance have received much attention: the production of high concentrations of organic osmolytes (glucose, glycerol, urea among amphibians) that protect the intracellular environment, and the control of ice within the body (the first putative ice-binding protein in a frog was recently identified), but many other strategies of biochemical adaptation also contribute to freezing survival...
April 2017: Physiological Reviews
https://www.readbyqxmd.com/read/28174563/metabolic-flexibility-of-yarrowia-lipolytica-growing-on-glycerol
#10
Michael Egermeier, Hannes Russmayer, Michael Sauer, Hans Marx
The yeast Yarrowia lipolytica is a fascinating microorganism with an amazing metabolic flexibility. This yeast grows very well on a wide variety of carbon sources from alkanes over lipids, to sugars and glycerol. Y. lipolytica accumulates a wide array of industrially relevant metabolites. It is very tolerant to many environmental factors, above all the pH value. It grows perfectly well over a wide pH range, but it has been described, that the pH has a decisive influence on the metabolite pattern accumulated by this yeast...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28171830/a-review-on-antioxidant-potential-of-bioactive-heterocycle-benzofuran-natural-and-synthetic-derivatives
#11
REVIEW
Karam Chand, Rajeshwari, Asha Hiremathad, Mahak Singh, M Amelia Santos, Rangappa S Keri
The majority of heterocycle compounds and typically common heterocycle fragments present in most pharmaceuticals currently marketed, alongside with their intrinsic versatility and unique physicochemical properties, have poised them as true cornerstones of medicinal chemistry. In this context, oxygen heterocycles exhibit diverse biological and pharmacological activities due in part to the similarities with many natural and synthetic molecules with known biological activity. Among oxygen containing heterocycles, benzofuran (synthetic and natural isolated) and its derivatives have attracted medicinal chemists and pharmacologists due to their pronounced biological activities and their potential applications as pharmacological agents such as antioxidant, antitumor, antiplatelet, antimalarial, antiinflammatory, antidepressant and anticonvulsant properties...
November 18, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28166601/mechanisms-of-cellular-activation-in-the-antiphospholipid-syndrome
#12
Nadine Müller-Calleja, Karl J Lackner
It is long known that antiphospholipid antibodies (aPL) induce proinflammatory and procoagulant cellular responses. The underlying signal transduction has been a major focus of research and is the topic of this review. An amazingly heterogeneous panel of signaling pathways has been described and it turns out that at least some of this heterogeneity can be explained by effects of distinct aPL species. On the one hand, there are antibodies against β2-glycoprotein I (β2GPI) which appear to exert their cellular effects only as a complex of β2GPI/anti-β2GPI...
February 6, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28165130/diastolic-function-deterioration-in-type-2-diabetes-mellitus-predictive-factors-over-a-3-year-follow-up
#13
Cyrille Bergerot, Einar Skulstad Davidsen, Camille Amaz, Hélène Thibault, Mikhail Altman, Amandine Bellaton, Philippe Moulin, Geneviève Derumeaux, Laura Ernande
No abstract text is available yet for this article.
February 6, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28157910/compressive-holography-algorithm-for-the-objects-composed-of-point-sources
#14
Jing Liu, Guoxian Zhang, Kai Zhao, Xiaoyu Jiang
A compressive holography algorithm is proposed for the objects composed of point sources in this work. The proposed algorithm is based on Gabor holography, an amazingly simple and effective encoder for compressed sensing. In the proposed algorithm, the three-dimensional sampling space is uniformly divided into a number of grids since the virtual object may appear anywhere in the sampling space. All the grids are mapped into an indication vector, which is sparse in nature considering that the number of grids occupied by the virtual object is far less than that of the whole sampling space...
January 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28157340/interplay-between-magnetism-superconductivity-and-orbital-order-in-5-pocket-model-for-iron-based-superconductors-parquet-renormalization-group-study
#15
Laura Classen, Rui-Qi Xing, Maxim Khodas, Andrey V Chubukov
We report the results of the parquet renormalization group (RG) analysis of the phase diagram of the most general 5-pocket model for Fe-based superconductors. We use as an input the orbital structure of excitations near the five pockets made out of d_{xz}, d_{yz}, and d_{xy} orbitals and argue that there are 40 different interactions between low-energy fermions in the orbital basis. All interactions flow under the RG, as one progressively integrates out fermions with higher energies. We find that the low-energy behavior is amazingly simple, despite the large number of interactions...
January 20, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28145167/-our-nurse-has-been-an-amazing-advocate-for-our-non-verbal-child
#16
(no author information available yet)
My son Conor is an 11-year-old boy with a rare genetic condition called Cornelia de Lange Syndrome and complex needs. We have encountered many medical and nursing staff on our journey, but learning disability community nurse Lisa Harris, who works for the Western Health and Social Care Trust in Derry, Northern Ireland, stands out.
February 1, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28137426/scientific-familial-lessons-in-ingestive-behavior-research-2016-alan-n-epstein-research-award
#17
REVIEW
Matthew R Hayes
While energy balance is under the control of the central nervous system (CNS), a major source of neural regulation for the behavioral, physiological and endocrine processes governing energy balance originates in the periphery. Indeed, the organs of the gastrointestinal (GI) tract, supporting organs of the peritoneal cavity and adipose tissue are the source of numerous neurotransmitter and neuroendocrine signals released from non-neuronal peripheral tissue that signal in a paracrine and endocrine fashion to regulate the physiological and behavioral processes that affect energy balance...
January 27, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28135603/development-of-a-novel-integrated-process-for-co-production-of-%C3%AE-galactosidase-and-ethanol-using-lactose-as-substrate
#18
Shengping You, Jianye Zhang, Qingdian Yin, Wei Qi, Rongxin Su, Zhimin He
A novel integrated process was developed successfully for co-production of β-galactosidase and ethanol using lactose as substrate, containing fermentation (Kluyveromyces lactis), isolation, permeabilization (a new recycling process) and spray drying. Firstly, a new fed-batch strategy optimized co-produced β-galactosidase at 105.91U/mL and ethanol at 32.16mg/mL, 4.40-fold and 10.82-fold increase over the results from initial conditions, respectively. Then a new mathematic model for the recycling permeabilization was established successfully...
January 12, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28135400/the-amazingly-rapid-birth-growth-and-maturing-of-digital-computer-modeling-in-hydrogeology
#19
Fred J Molz
No abstract text is available yet for this article.
January 30, 2017: Ground Water
https://www.readbyqxmd.com/read/28124155/exploiting-the-gastric-epithelial-barrier-helicobacter-pylori-s-attack-on-tight-and-adherens-junctions
#20
Steffen Backert, Thomas P Schmidt, Aileen Harrer, Silja Wessler
Highly organized intercellular tight and adherens junctions are crucial structural components for establishing and maintenance of epithelial barrier functions, which control the microbiota and protect against intruding pathogens in humans. Alterations in these complexes represent key events in the development and progression of multiple infectious diseases as well as various cancers. The gastric pathogen Helicobacter pylori exerts an amazing set of strategies to manipulate these epithelial cell-to-cell junctions, which are implicated in changing cell polarity, migration and invasive growth as well as pro-inflammatory and proliferative responses...
2017: Current Topics in Microbiology and Immunology
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