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https://www.readbyqxmd.com/read/28434111/idh-mutation-and-1p19q-codeletion-distinguish-two-radiological-patterns-of-diffuse-low-grade-gliomas
#1
Amélie Darlix, Jérémy Deverdun, Nicolas Menjot de Champfleur, Florence Castan, Sonia Zouaoui, Valérie Rigau, Michel Fabbro, Yordanka Yordanova, Emmanuelle Le Bars, Luc Bauchet, Catherine Gozé, Hugues Duffau
Diffuse low-grade gliomas (DLGG) prognosis is variable, depending on several factors, including the isocitrate dehydrogenase (IDH) mutation and the 1p19q codeletion. A few studies suggested associations between these parameters and tumor radiological characteristics including topography. Our aim was analyzing the correlations between the IDH and 1p19q statuses and the tumor intracerebral distribution (at the lobar and voxel levels), volume, and borders. We conducted a retrospective, monocentric study on a consecutive series of 198 DLGG patients...
April 22, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28434051/evidence-of-a-link-between-fever-and-microscopic-hematuria-in-children
#2
Rama Schwartz, Rotem Distal, Arthur Shapiro, Yehezkel Waisman
Despite the common conception that febrile illnesses are associated with microscopic hematuria in children, a review of the literature failed to disclose supportive evidence. The aim of this study was to evaluate this relationship. Background data were collected for a convenience sample of children aged 4-18 years who presented to the emergency department (ED) of a tertiary pediatric medical center. Vital signs were measured and a midstream urine specimen was collected. Specimens positive for the presence of blood (>5 erythrocytes/μl; Combur 10 Test Strips) were examined microscopically...
April 22, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28434016/chronic-rhinosinusitis-and-mood-disturbance
#3
S E Erskine, C Hopkins, A Clark, S Anari, A Robertson, S Sunkaraneni, J A Wilson, J Beezhold, C M Philpott
BACKGROUND: This study is part of the Chronic Rhinosinusitis Epidemiology Study (CRES). The overarching aim is to determine factors that influence the onset and severity of chronic rhinosinusitis (CRS). The aim of this analysis is to determine whether those with CRS are more likely to report psychiatric morbidity and in particular mood disturbance compared with healthy controls. METHODS: CRES consists of a study-specific questionnaire regarding demographic and socioeconomic factors and past medical history as well as a nasal symptom score (SNOT-22) and SF-36 (QoL - quality of life tool)...
April 23, 2017: Rhinology
https://www.readbyqxmd.com/read/28433894/a-functional-snp-mcp-1-2518a-g-predispose-to-renal-disorder-in-indian-systemic-lupus-erythematosus-patients
#4
Vinod D Umare, Vandana D Pradhan, Anjali G Rajadhyaksha, Kanjaksha Ghosh, Anita H Nadkarni
Systemic Lupus Erythematosus (SLE) is a clinically heterogeneous chronic, inflammatory autoimmune disorder that affects multiple organs where exact etiology of the disease is not yet clearly understood. Various evidences suggest that genetic polymorphisms in inflammatory mediators like cytokines and chemokines may influence development of the disease. Here, we investigated whether functional polymorphism at the Monocyte Chemoattractant Protein-1 (MCP-1) regulatory region associates with disease phenotype in Indian SLE patients...
April 20, 2017: Cytokine
https://www.readbyqxmd.com/read/28433848/instrumented-circumferential-fusion-in-two-stages-for-instable-lumbar-fracture-long-term-results-of-a-series-of-74-patients-on-sagittal-balance-and-functional-outcomes
#5
Mourad Ould-Slimane, Camille Damade, Guillaume Lonjon, André Gilibert, Jérôme Cochereau, Rémi Gauthé, Nicolas Lonjon
AIM: To report the radiological and functional results of a multicentre, prospective case series of patients with comminuted lumbar fractures treated with two-stage circumferential arthrodesis. METHODS: A multicentre, prospective case series of 74 patients with comminuted lumbar fractures was analyzed. The strategy entailed initial posterior osteosynthesis then physical replacement with an expandable titanium cage filled with autologous bone, via retroperitoneal lumbotomy...
April 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28433825/a-distributed-framework-for-health-information-exchange-using-smartphone-technologies
#6
Mohamed Abdulnabi, Ahmed Al-Haiqi, Mlm Kiah, A A Zaidan, B B Zaidan, Muzammil Hussein
Nationwide health information exchange (NHIE) continues to be a persistent concern for government agencies, despite the many efforts and the conceived benefits of sharing patient data among healthcare providers. Difficulties in ensuring global connectivity, interoperability, and concerns on security have always hampered the government from successfully deploying NHIE. By looking at NHIE from a fresh perspective and bearing in mind the pervasiveness and power of modern mobile platforms, this paper proposes a new approach to NHIE that builds on the notion of consumer-mediated HIE, albeit without the focus on central health record banks...
April 19, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28433369/fertility-preservation-and-refreezing-of-transplanted-ovarian-tissue-a-potential-new-way-of-managing-patients-with-low-risk-of-malignant-cell-recurrence
#7
Stine Gry Kristensen, Veronica Giorgione, Peter Humaidan, Birgit Alsbjerg, Anne-Mette Bay Bjørn, Erik Ernst, Claus Yding Andersen
OBJECTIVE: To report the first successful refreezing of ovarian tissue recovered more than 3 years after transplantation in a woman previously treated for early-stage ovarian cancer. DESIGN: Evaluation of cryopreserved and grafted ovarian tissue. SETTING: University hospital. PATIENT(S): A 23-year-old woman diagnosed with stage 1C ovarian mucinous cystadenocarcinoma. INTERVENTION(S): The patient underwent ovarian tissue cryopreservation for fertility preservation and subsequent heterotopic transplantation for fertility restoration 9 years after freezing...
April 19, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28433210/non-tuberculous-mycobacteria-an-emerging-threat
#8
Susana Martínez González, Arantxa Cano Cortés, Luis Alfonso Sota Yoldi, José María García García, Luz María Alba Álvarez, Juan José Palacios Gutiérrez
INTRODUCTION AND OBJECTIVE: Non-tuberculous mycobacteria (NTM) isolates are becoming more common. The main objective of our study was to establish the number and diversity of NTM species in our region and their distribution according to the source sample, age and gender of the patients, and to analyse clinically significant isolates. METHODOLOGY: Prospective study of all NTM isolated in Asturias from 2005 to 2012. Samples were processed following internationally accepted guidelines...
April 19, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28432738/tick-bite-and-lyme-disease-related-emergency-department-encounters-in-new-hampshire-2010-2014
#9
E R Daly, C Fredette, A A Mathewson, K Dufault, D J Swenson, B P Chan
Lyme disease (LD) is a common tick-borne disease in New Hampshire (NH). While LD is a reportable condition and cases are counted for public health surveillance, many more people receive care for tick bites or diagnoses of LD than are reflected in surveillance data. NH's emergency department (ED) data system was queried for tick bite and LD-related encounters. Chief complaint text was queried for words related to LD or tick bites. International Classification of Diseases 9th Revision (ICD-9) codes were queried for the LD diagnosis code (088...
April 22, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28432674/partial-volume-correction-of-brain-pet-studies-using-iterative-deconvolution-in-combination-with-hypr-denoising
#10
Sandeep S V Golla, Mark Lubberink, Bart N M van Berckel, Adriaan A Lammertsma, Ronald Boellaard
BACKGROUND: Accurate quantification of PET studies depends on the spatial resolution of the PET data. The commonly limited PET resolution results in partial volume effects (PVE). Iterative deconvolution methods (IDM) have been proposed as a means to correct for PVE. IDM improves spatial resolution of PET studies without the need for structural information (e.g. MR scans). On the other hand, deconvolution also increases noise, which results in lower signal-to-noise ratios (SNR). The aim of this study was to implement IDM in combination with HighlY constrained back-PRojection (HYPR) denoising to mitigate poor SNR properties of conventional IDM...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28432523/hypothesis-free-analyses-from-a-large-psoriatic-arthritis-cohort-support-merger-to-consolidated-peripheral-arthritis-definition-without-subtyping
#11
Daniel Stekhoven, Almut Scherer, Michael J Nissen, Véronique Grobéty, Nikhil Yawalkar, Peter M Villiger, Burkhard Möller
Current ClASsification criteria for Psoriatic ARthritis classification criteria for psoriatic arthritis (PsA) provide a preliminary definition of inflammatory articular disease. This study aimed to further characterize PsA peripheral arthritis using purely data-driven approaches for the affected joint distribution pattern. PsA patients from the Swiss Clinical Quality Management in Rheumatic Diseases (SCQM) database were clustered according to similarities in 66 swollen and in 68 tender joints. Clusters were compared in terms of other disease characteristics and studied for coincidence with traditional PsA subtypes, stability over time and treatment response upon first tumour necrosis factor alpha (TNF-α) therapy...
April 22, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28432512/squamous-cell-carcinoma-of-the-breast-in-the-united-states-incidence-demographics-tumor-characteristics-and-survival
#12
Siddhartha Yadav, Dhiraj Yadav, Dana Zakalik
PURPOSE: Squamous cell carcinoma of breast accounts for less than 0.1% of all breast cancers. The purpose of this study is to describe the epidemiology and survival of this rare malignancy. METHODS: Data were extracted from the National Cancer Institute's Surveillance, Epidemiology and End Results Registry to identify women diagnosed with squamous cell carcinoma of breast between 1998 and 2013. SEER*Stat 8.3.1 was used to calculate age-adjusted incidence, age-wise distribution, and annual percentage change in incidence...
April 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28432458/is-the-evaluation-of-the-anterior-inferior-iliac-spine-aiis-in-the-ap-pelvis-possible-analysis-of-conventional-x-rays-and-3d-ct-reconstructions
#13
David R Krueger, Markus Windler, Markus Geßlein, Michael Schuetz, Carsten Perka, Joerg H Schroeder
INTRODUCTION: A hypertrophic AIIS has been identified as a cause for extraarticular hip impingement and is classified according to Hetsroni using 3D-CT reconstructions. The role of the conventional AP pelvis X-ray, which is the first standard imaging step for the evaluation of hip pain, has not been investigated yet. MATERIALS AND METHODS: AP pelvis X-rays and 3D-CT reconstructions of patients were evaluated regarding their morphology of the AIIS. The conventional X-rays were categorized into three groups according to the projection of the AIIS: above (A) or below (B) the acetabular sourcil or even exceeding the anterior acetabular rim (C)...
April 21, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28432437/an-italian-multicentre-study-on-adult-atopic-dermatitis-persistent-versus-adult-onset-disease
#14
Matteo Megna, Cataldo Patruno, Anna Balato, Franco Rongioletti, Luca Stingeni, Nicola Balato
Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disease which predominantly affects children. However, AD may persist until adulthood (persistent AD), or directly start in adults (adult-onset AD). AD often shows a non-flexural rash distribution, and atypical morphologic variants in adults and specific diagnostic criteria are lacking. Moreover, adult AD prevalence as well as detailed data which can characterize persistent vs adult-onset subtype are scant. The aim of this study was to investigate on the main features of adult AD particularly highlighting differences between persistent vs adult-onset form...
April 21, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28432321/mycobacterium-tuberculosis-lineage-distribution-in-xinjiang-and-gansu-provinces-china
#15
Haixia Chen, Li He, Hairong Huang, Chengmin Shi, Xumin Ni, Guangming Dai, Liang Ma, Weimin Li
Mycobacterium tuberculosis (M. tuberculosis) genotyping has dramatically improved the understanding of the epidemiology of tuberculosis (TB). In this study, 187 M. tuberculosis isolates from Xinjiang Uygur Autonomous Region (Xinjiang) and Gansu province in China were genotyped using large sequence polymorphisms (LSPs) and variable number tandem repeats (VNTR). Ten isolates, which represent major nodes of VNTR-based minimum spanning tree, were selected and subsequently subjected to multi-locus sequence analyses (MLSA) that include 82 genes...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28432052/genomic-instability-in-cancer-teetering-on-the-limit-of-tolerance
#16
REVIEW
Noemi Andor, Carlo C Maley, Hanlee P Ji
Cancer genomic instability contributes to the phenomenon of intratumoral genetic heterogeneity, provides the genetic diversity required for natural selection, and enables the extensive phenotypic diversity that is frequently observed among patients. Genomic instability has previously been associated with poor prognosis. However, we have evidence that for solid tumors of epithelial origin, extreme levels of genomic instability, where more than 75% of the genome is subject to somatic copy number alterations, are associated with a potentially better prognosis compared with intermediate levels under this threshold...
April 21, 2017: Cancer Research
https://www.readbyqxmd.com/read/28432018/on-the-role-of-api-in-determining-porosity-pore-structure-and-bulk-modulus-of-the-skeletal-material-in-pharmaceutical-tablets-formed-with-mcc-excipient
#17
Cathy Ridgway, Prince Bawuah, Daniel Markl, J Axel Zeitler, Jarkko Ketolainen, Kai-Erik Peiponen, Patrick Gane
The physical properties and mechanical integrity of pharmaceutical tablets are of major importance when loading with active pharmaceutical ingredient(s) (API) in order to ensure ease of processing, control of dosage and stability during transportation and handling prior to patient consumption. The interaction between API and excipient, acting as functional extender and binder, however, is little understood in this context. The API indomethacin is combined in this study with microcrystalline cellulose (MCC) at increasing loading levels...
April 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28431885/safety-of-adding-oats-to-a-gluten-free-diet-for-patients-with-celiac-disease-systematic-review-and-meta-analysis-of-clinical-and-observational-studies
#18
María Inés Pinto-Sánchez, Natalia Causada-Calo, Premysl Bercik, Alexander C Ford, Joseph A Murray, David Armstrong, Carol Semrad, Sonia S Kupfer, Armin Alaedini, Paul Moayyedi, Daniel A Leffler, Elena F Verdú, Peter Green
BACKGROUND & AIMS: Patients with celiac disease should maintain a gluten-free diet (GFD), excluding wheat, rye, and barley. Oats might increase the nutritional value of a GFD, but their including is controversial. We performed a systematic review and meta-analysis to evaluate the safety of oats as part of a GFD in patients with celiac disease. METHODS: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, and EMBASE databases for clinical trials and observational studies of the effects of including oats in GFD of patients with celiac disease...
April 18, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28431798/absence-of-myoepithelial-cells-correlates-with-invasion-and-metastasis-of-carcinoma-ex-pleomorphic-adenoma
#19
P Ye, Y Gao, T Wei, G-Y Yu, X Peng
Myoepithelial cells (MECs) are implicated in the development and progression of human salivary gland tumours. Here, we investigate the potential role for MECs in invasion and metastasis of carcinoma ex pleomorphic adenoma (CXPA). Tumour tissues from 40 CXPA patients diagnosed between 1960 and 2014 were obtained. Patient samples were divided into two groups (non-invasive tumours, n=10; and frankly invasive tumours, n=30). Each group was further divided into two subgroups (metastatic tumours and non-metastatic tumours)...
April 18, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28431790/-barriers-to-referral-to-pulmonary-rehabilitation-in-copd-patients-from-the-perspective-of-general-practitioners
#20
O Galera, G Grimal, D Bajon, Y Darolles
INTRODUCTION: In spite of recommendations of the highest level of proof (rank A), the respiratory rehabilitation remains very widely sub-prescribed by general practitioners, who are nevertheless in the front line in the care and the follow-up of the patients affected by BPCO. MATERIAL AND METHODS: Semi-qualitative study with the general practitioners installed in the city of Montauban (Tarn-et-Garonne). RESULTS: The rate of answer was 57%...
April 18, 2017: Revue de Pneumologie Clinique
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