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https://www.readbyqxmd.com/read/28227275/an-algorithm-for-automatic-detection-of-drowsiness-for-use-in-wearable-eeg-systems
#1
Kwai C A Patrick, Syed Anas Imtiaz, Stuart Bowyer, Esther Rodriguez-Villegas, Kwai C A Patrick, Syed Anas Imtiaz, Stuart Bowyer, Esther Rodriguez-Villegas, Kwai C A Patrick, Esther Rodriguez-Villegas, Stuart Bowyer
Lack of proper restorative sleep can induce sleepiness at odd hours making a person drowsy. This onset of drowsiness can be detrimental for the individual in a number of ways if it happens at an unwanted time. For example, drowsiness while driving a vehicle or operating heavy machinery poses a threat to the safety and wellbeing of individuals as well as those around them. Timely detection of drowsiness can prevent the occurrence of unfortunate accidents thereby improving road and work environment safety. In this paper, by analyzing the electroencephalographic (EEG) signals of human subjects in the frequency domain, several features across different EEG channels are explored...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28221196/fdg-brain-pet-ct-revealing-bilateral-thalamostriatal-activation-during-a-symptomatic-episode-in-a-patient-with-kleine-levin-syndrome
#2
Clément Drouet, Olivier Morel, Antoine Verger, Eric Guedj, Hatem Boulahdour
We report the case of a 14-year-old girl with clinically diagnosed Kleine-Levin syndrome. Electroencephalogram and brain MRI were unremarkable. An FDG PET/CT scan was acquired during a symptomatic episode, while she was asleep, and another PET scan was obtained when she was asymptomatic, awake, and quiet. Comparison of both examinations demonstrated a bilateral activation of thalami, caudate nuclei, and lenticular nuclei. These findings may be linked to the implication of thalamostriatal structures in the regulation of sleep and wakefulness...
February 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28219726/diagnostic-value-of-sleep-stage-dissociation-as-visualized-on-a-2-dimensional-sleep-state-space-in-human-narcolepsy
#3
Anders Vinther Olsen, Jens Stephansen, Eileen Leary, Paul E Peppard, Hong Sheungshul, Poul Jenum, Helge Sorensen, Emmanuel Mignot
BACKGROUND: Type 1 narcolepsy (NT1) is characterized by symptoms believed to represent Rapid Eye Movement (REM) sleep stage dissociations, occurrences where features of wake and REM sleep are intermingled, resulting in a mixed state. We hypothesized that sleep stage dissociations can be objectively detected through the analysis of nocturnal Polysomnography (PSG) data, and that those affecting REM sleep can be used as a diagnostic feature for narcolepsy. NEW METHOD: A Linear Discriminant Analysis (LDA) model using 38 features extracted from EOG, EMG and EEG was used in control subjects to select features differentiating wake, stage N1, N2, N3 and REM sleep...
February 17, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28204773/eeg-functional-connectivity-prior-to-sleepwalking-evidence-of-interplay-between-sleep-and-wakefulness
#4
Marie-Ève Desjardins, Julie Carrier, Jean-Marc Lina, Maxime Fortin, Nadia Gosselin, Jacques Montplaisir, Antonio Zadra
No abstract text is available yet for this article.
February 13, 2017: Sleep
https://www.readbyqxmd.com/read/28173758/sleep-wake-movement-velocities-trajectories-and-micro-arousals-during-maturation-in-rats
#5
Gideon Gradwohl, Nadja Olini, Reto Huber
BACKGROUND: Sleep is regulated by two main processes. The circadian process provides a 24-h rhythm and the homeostatic process reflects sleep pressure, which increases in the course of wakefulness and decreases during sleep. Both of these processes undergo major changes during development. For example, sleep homeostasis, measured by means of electroencephalogram (EEG) slow-wave activity (SWA, EEG power between 0.5 and 4.5 Hz), peaks around puberty and decreases during adolescence. In humans and rats these changes have been related to cortical maturation...
February 7, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28155104/estimating-sleep-time-from-non-eeg-based-psg-signals-in-the-diagnosis-of-sleep-disordered-breathing
#6
M B Norman, C E Sullivan
PURPOSE: The purpose of this study was to use non-EEG PSG signals to estimate TST in order to diagnose SDB with a greater sensitivity than type 3 device methodology that relies on TRT. METHODS: Movement patterns were obtained from the thoracoabdominal signals of adult PSG recordings (n = 60) in the laboratory and the home. Parameters obtained allowed, with 95% certainty, identification of sleep and wake based on the duration of movements and quiescent time (Qd)...
February 3, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28139776/accurate-discrimination-of-the-wake-sleep-states-of-mice-using-non-invasive-whole-body-plethysmography
#7
Stefano Bastianini, Sara Alvente, Chiara Berteotti, Viviana Lo Martire, Alessandro Silvani, Steven J Swoap, Alice Valli, Giovanna Zoccoli, Gary Cohen
A major limitation in the study of sleep breathing disorders in mouse models of pathology is the need to combine whole-body plethysmography (WBP) to measure respiration with electroencephalography/electromyography (EEG/EMG) to discriminate wake-sleep states. However, murine wake-sleep states may be discriminated from breathing and body movements registered by the WBP signal alone. Our goal was to compare the EEG/EMG-based and the WBP-based scoring of wake-sleep states of mice, and provide formal guidelines for the latter...
January 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28122495/evoked-potentials-and-behavioral-performance-during-different-states-of-brain-arousal
#8
Jue Huang, Tilman Hensch, Christine Ulke, Christian Sander, Janek Spada, Philippe Jawinski, Ulrich Hegerl
BACKGROUND: Previous studies compared evoked potentials (EPs) between several sleep stages but only one uniform wake state. However, using electroencephalography (EEG), several arousal states can be distinguished before sleep onset. Recently, the Vigilance Algorithm Leipzig (VIGALL 2.0) has been developed, which automatically attributes one out of seven EEG-vigilance stages to each 1-s EEG segment, ranging from stage 0 (associated with cognitively active wakefulness), to stages A1, A2 and A3 (associated with relaxed wakefulness), to stages B1 and B2/3 (associated with drowsiness) up to stage C (indicating sleep onset)...
January 25, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28111743/does-sleep-benefit-memory-consolidation-in-children-with-focal-epilepsy
#9
Samantha Chan, Ronit Pressler, Stewart G Boyd, Torsten Baldeweg, J Helen Cross
OBJECTIVE: Children with epilepsy have high rates of both cognitive impairment and sleep disruption. It is thus assumed that sleep-dependent memory consolidation is vulnerable to ongoing epileptic activity, but direct evidence of this is limited. METHODS: We performed a within-subject comparison of memory retention across intervals of wake or overnight sleep. Healthy children (n = 21, 6-16 years, 12 female) and children with focal epilepsy (n = 22, 6-16 years, 9 female) performed verbal and visuospatial memory tasks under each condition...
January 23, 2017: Epilepsia
https://www.readbyqxmd.com/read/28109896/the-nlrp3-inflammasome-modulates-sleep-and-nrem-sleep-delta-power-induced-by-spontaneous-wakefulness-sleep-deprivation-and-lipopolysaccharide
#10
Mark R Zielinski, Dmitry Gerashchenko, Svetlana A Karpova, Varun Konanki, Robert W McCarley, Fayyaz S Sutterwala, Robert E Strecker, Radhika Basheer
Both sleep loss and pathogens can enhance brain inflammation, sleep, and sleep intensity as indicated by electroencephalogram delta (δ) power. The pro-inflammatory cytokine interleukin-1 beta (IL-1β) is increased in the cortex after sleep deprivation (SD) and in response to the Gram-negative bacterial cell-wall component lipopolysaccharide (LPS), although the exact mechanisms governing these effects are unknown. The nucleotide-binding domain and leucine-rich repeat protein-3 (NLRP3) inflammasome protein complex forms in response to changes in the local environment and, in turn, activates caspase-1 to convert IL-1β into its active form...
January 18, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28102151/pleiotropic-genetic-effects-influencing-sleep-and-neurological-disorders
#11
REVIEW
Olivia J Veatch, Brendan T Keenan, Philip R Gehrman, Beth A Malow, Allan I Pack
Research evidence increasingly points to the large impact of sleep disturbances on public health. Many aspects of sleep are heritable and genes influencing traits such as timing, EEG characteristics, sleep duration, and response to sleep loss have been identified. Notably, large-scale genome-wide analyses have implicated numerous genes with small effects on sleep timing. Additionally, there has been considerable progress in the identification of genes influencing risk for some neurological sleep disorders. For restless legs syndrome, implicated variants are typically in genes associated with neuronal development...
February 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28098351/the-elicitation-of-steady-state-visual-evoked-potentials-during-sleep
#12
James J S Norton, Stephen Umunna, Timothy Bretl
This study confirmed the hypothesis that it is possible to elicit SSVEPs through closed eyelids during NREM sleep. To test this hypothesis, SSVEP amplitudes were measured in eight subjects across two conditions of stimulation (stimulation on and stimulation off) and three brain states (waking, light sleep, and deep sleep). Results showed a significant interaction between stimulation and brain state. In particular, EEG activity at the frequency of stimulation was higher during both light sleep and deep sleep in the stimulation on condition than in the stimulation off condition...
January 18, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28087845/waking-eeg-cortical-markers-of-chronic-pain-and-sleepiness
#13
Danny Camfferman, G Lorimer Moseley, Kevin Gertz, Mark W Pettet, Mark P Jensen
OBJECTIVE: Spectral power analyses of EEG recordings are reported to distinguish the cortical activity of individuals with chronic pain from those of controls. Further study of these spectral patterns may provide a greater understanding of the processes associated with chronic pain, in addition to providing potential biometric markers of chronic pain for use in both clinical and research settings. However, sleep deprived groups have demonstrated similar characteristics in their spectral power characteristics, particularly in alpha bandwidth power activity...
January 13, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28077269/association-of-an-individual-s-ability-to-overcome-desire-to-fall-asleep-with-a-higher-anterior-posterior-gradient-in-electroencephalographic-indexes-of-sleep-pressure
#14
Arcady A Putilov, Olga G Donskaya
Individual differences in ability to overcome desire to fall asleep cannot be accurately predicted from subjective and objective measurements of sleepiness level. Previously, we showed that an exponential buildup of sleep pressure during prolonged wakefulness can be accurately traced with electroencephalographic (EEG) indexes, such as Spectral Sleep Pressure Component (SSPC) score and score on the 2nd principal component (2PC) of the EEG spectrum. The anterior-posterior gradients in SSPC and 2PC scores were calculated as the differences between frontal and occipital scores and examined as possible correlates of individual's ability to overcome desire of falling asleep...
January 7, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28057087/sleep-homeostatic-and-waking-behavioral-phenotypes-in-egr3-deficient-mice-associated-with-serotonin-receptor-5-ht2-deficits
#15
Janne Grønli, William C Clegern, Michelle A Schmidt, Rahmi S Nemri, Michael J Rempe, Amelia L Gallitano, Jonathan P Wisor
STUDY OBJECTIVE: The expression of the immediate early gene early growth response 3 (Egr3) is a functional marker of brain activity including responses to novelty, sustained wakefulness, and sleep. We examined the role of this gene in regulating wakefulness and sleep. METHODS: Electroencephalogram/electromyogram (EEG/EMG) were recorded in Egr3-/- and wild-type (WT) mice during 24 h baseline, 6 h sleep disruption and 6 h recovery. Serotonergic signaling was assessed with 6 h EEG/EMG recordings after injections of nonselective 5-HT2 antagonist (clozapine), selective 5-HT2 antagonists (5-HT2A; MDL100907 and 5-HT2BC; SB206553) and a cocktail of both selective antagonists, administered in a randomized order to each animal...
December 1, 2016: Sleep
https://www.readbyqxmd.com/read/28050973/behavioral-state-classification-in-epileptic-brain-using-intracranial-electrophysiology
#16
Vaclav Kremen, Juliano J Duque, Benjamin H Brinkmann, Brent M Berry, Michal T Kucewicz, Fatemeh Khadjevand, Jamie Van Gompel, Matt Stead, Erik K St Louis, Gregory A Worrell
OBJECTIVE: Automated behavioral state classification can benefit next generation implantable epilepsy devices. In this study we explored the feasibility of automated awake (AW) and slow wave sleep (SWS) classification using wide bandwidth intracranial EEG (iEEG) in patients undergoing evaluation for epilepsy surgery. APPROACH: Data from seven patients (age [Formula: see text], 4 women) who underwent intracranial depth electrode implantation for iEEG monitoring were included...
January 4, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28045040/the-fall-of-sleep-k-complex-in-alzheimer-disease
#17
Luigi De Gennaro, Maurizio Gorgoni, Flaminia Reda, Giulia Lauri, Ilaria Truglia, Susanna Cordone, Serena Scarpelli, Anastasia Mangiaruga, Aurora D'atri, Giordano Lacidogna, Michele Ferrara, Camillo Marra, Paolo Maria Rossini
Although a slowing of electroencephalographic (EEG) activity during wakefulness and -to some extent- sleep of Alzheimer disease (AD) patients (i.e., increased slow-frequency activity) was documented, recent findings in healthy elderly show a decreased 0.6-1 Hz slow wave activity (SWA) during NREM, which was associated to β-amyloid deposition and impaired hippocampal memory consolidation. We hypothesize that the apparent contradiction may be explained by the partial overlap between 0.6-1 Hz EEG activity and K-Complex (KC)...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28043770/sleep-related-modifications-of-eeg-connectivity-in-the-sensory-motor-networks-in-huntington-disease-an-eloreta-study-and-review-of-the-literature
#18
Carla Piano, Claudio Imperatori, Anna Losurdo, Anna Rita Bentivoglio, Pietro Cortelli, Giacomo Della Marca
OBJECTIVE: To evaluate EEG functional connectivity in the sensory-motor network, during wake and sleep, in patients with Huntington Disease (HD). METHODS: 23 patients with HD and 23 age- and sex-matched healthy controls were enrolled. EEG connectivity analysis was performed by means of exact Low Resolution Electric Tomography (eLORETA). RESULTS: In wake, HD patients showed an increase of delta lagged phase synchronization (T=3.60; p<0.05) among Broadman's Areas (BA) 6-8 bilaterally; right BA 6-8 and right BA 1-2-3; left BA 1-2-3 and left BA 4...
December 5, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28039375/cholinergic-glutamatergic-and-gabaergic-neurons-of-the-pedunculopontine-tegmental-nucleus-have-distinct-effects-on-sleep-wake-behavior-in-mice
#19
Daniel Kroeger, Loris L Ferrari, Gaetan Petit, Carrie E Mahoney, Patrick M Fuller, Elda Arrigoni, Thomas E Scammell
: The pedunculopontine tegmental (PPT) nucleus has long been implicated in the regulation of cortical activity and behavioral states, including rapid eye-movement (REM) sleep. For example, electrical stimulation of the PPT region during sleep leads to rapid awakening, whereas lesions of the PPT in cats reduce REM sleep. Though these effects have been linked with the activity of cholinergic PPT neurons, the PPT also includes intermingled glutamatergic and GABAergic cell populations, and the precise roles of cholinergic, glutamatergic, and GABAergic PPT cell groups in regulating cortical activity and behavioral state remain unknown...
February 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28027860/from-nocturnal-frontal-lobe-epilepsy-to-sleep-related-hypermotor-seizures-a-35-year-diagnostic-challenge
#20
Paolo Tinuper, Francesca Bisulli
Nocturnal frontal lobe epilepsy (NFLE) is a focal epilepsy with seizures arising mainly during sleep and characterized by complex, often bizarre, motor behavior or sustained dystonic posturing. First described in 1981, it was initially considered a motor disorder of sleep and was named nocturnal paroxysmal dystonia (NPD). The unusual seizure semiology, onset during sleep, and often uninformative scalp EEG and brain MRI make it difficult to distinguish NPD attacks from other non-epileptic nocturnal paroxysmal events, namely parasomnias...
December 15, 2016: Seizure: the Journal of the British Epilepsy Association
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