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sleep wake eeg

Katarina Lazic, Jelena Petrovic, Jelena Ciric, Aleksandar Kalauzi, Jasna Saponjic
Postoperative sleep disorders, particularly the REM sleep disorder, may have a significant deleterious impact on postoperative outcomes and may contribute to the genesis of certain delayed postoperative complications. We have followed the effect of distinct anesthesia regimens (ketamine/diazepam vs. pentobarbital) over 6days following the induction of a stable anesthetized state in adult male Wistar rats, chronically instrumented for sleep recording. In order to compare the effect of both anesthetics in the physiological controls vs...
October 19, 2016: Physiology & Behavior
V M Kovalzon, L S Moiseenko, A V Ambaryan, S Kurtenbach, V I Shestopalov, Y V Panchin
Pannexins are membrane channel proteins that play a role in a number of critical biological processes (Panchin et al., 2000; Shestopalov, Panchin, 2008). Among other cellular functions, pannexin hemichannels serve as purine nucleoside conduits providing ATP efflux into the extracellular space (Dahl, 2015), where it is rapidly degraded to adenosine. Pannexin1 (Panx1) is abundantly expressed in the brain and has been shown to contribute to adenosine signaling in nervous system tissues (Prochnow, 2012)...
October 18, 2016: Behavioural Brain Research
Dirk Jan Stenvers, Rick van Dorp, Ewout Foppen, Jorge Mendoza, Anne-Loes Opperhuizen, Eric Fliers, Peter H Bisschop, Johanna H Meijer, Andries Kalsbeek, Tom Deboer
Exposure to light at night (LAN) is associated with insomnia in humans. Light provides the main input to the master clock in the hypothalamic suprachiasmatic nucleus (SCN) that coordinates the sleep-wake cycle. We aimed to develop a rodent model for the effects of LAN on sleep. Therefore, we exposed male Wistar rats to either a 12 h light (150-200lux):12 h dark (LD) schedule or a 12 h light (150-200 lux):12 h dim white light (5 lux) (LDim) schedule. LDim acutely decreased the amplitude of daily rhythms of REM and NREM sleep, with a further decrease over the following days...
October 20, 2016: Scientific Reports
Akiyoshi Ishikawa, Keita Sakai, Takehiro Maki, Yuri Mizuno, Kimie Niimi, Yasuhiro Oda, Eiki Takahashi
To understand sleep mechanisms and develop treatments for sleep disorders, investigations using animal models are essential. The sleep architecture of rodents differs from that of diurnal mammals including humans and non-human primates. Sleep studies have been conducted in non-human primates; however, these sleep assessments were performed on animals placed in a restraint chair connected via the umbilical area to the recording apparatus. To avoid restraints, cables, and other stressful apparatuses and manipulations, telemetry systems have been developed...
October 18, 2016: Experimental Animals
Birgit Kleim, Julia Wysokowsky, Nuria Schmid, Erich Seifritz, Björn Rasch
STUDY OBJECTIVE: To investigate sleep's effect in the immediate aftermath of experiencing an analog trauma in the laboratory on reducing intrusive emotional memory formation. METHODS: Sixty-five healthy women were exposed to an experimental laboratory trauma. They viewed a neutral and a trauma film in the laboratory and were randomly allocated to either a group that slept following film viewing or a group that remained awake. Sleep was recorded with electroencephalogram in a subgroup of participants in the sleep group...
October 10, 2016: Sleep
Joshua J Emrick, Brooks A Gross, Brett T Riley, Gina R Poe
STUDY OBJECTIVES: Investigators assign sleep-waking states using brain activity collected from a single site, assuming that states occur at the same time throughout the brain. We sought to determine if sleep-waking states differ between two separate structures: the hippocampus and neocortex. METHODS: We measured electrical signals (electroencephalograms and electromyograms) during sleep from the hippocampus and neocortex of five freely behaving adult male rats. We assigned sleep-waking states in 10-sec epochs based on standard scoring criteria across a 4 h recording and analyzed and compared states and signals from simultaneous epochs between sites...
October 10, 2016: Sleep
Matthieu Dubois, Cécile Chenivesse, Mathieu Raux, Adrian Morales-Robles, Marie-Cécile Nierat, Gilles Garcia, Xavier Navarro-Sune, Mario Chavez, Jacques Martinerie, Thomas Similowski
: Spontaneous ventilation in mammals is driven by automatic brainstem networks that generate the respiratory rhythm and increase ventilation in the presence of increased carbon dioxide production. Hypocapnia decreases the drive to breathe and induces apnea. In humans, this occurs during sleep but not during wakefulness. We hypothesized that hypocapnic breathing would be associated with respiratory-related cortical activity similar to that observed during volitional breathing, inspiratory constraints, or in patients with defective automatic breathing (preinspiratory potentials)...
October 12, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Udaya Seneviratne, Ray C Boston, Mark Cook, Wendyl D'Souza
OBJECTIVE: We sought to investigate the temporal patterns and sleep-wake cycle-related epileptiform discharges (EDs) in genetic generalized epilepsies (GGEs). METHODS: We studied 24-hour ambulatory electroencephalography (EEG) recordings of patients with GGE, diagnosed and classified according to the International League against Epilepsy criteria. We manually coded the type of discharge, time of occurrence, duration, and arousal state of each ED. We employed mixed effects Poisson regression modeling to study the temporal distribution of epileptiform discharges...
October 7, 2016: Epilepsy & Behavior: E&B
Wei-Lun Lin, Li-Wei Lo, Hau-Ruey Chen, Chun-Ting Lai, Shinya Yamada, Shin-Huei Liu, Yu-Hui Chou, Shih-Ann Chen, Yun-Ching Fu, Terry B J Kuo
BACKGROUND: Autonomic imbalance with increased sympathetic and decreased parasympathetic activities is observed in patients after myocardial infarction (MI). We aimed to investigate sleep-related changed in autonomic regulation in left coronary artery (LCA) ligation rats. METHODS: Wireless transmission of polysomnographic recording was performed in sham and LCA ligation male rats during normal daytime sleep with and without atenolol treatment. Spectral analyses of the electroencephalogram (EEG) and electromyogram (EMG) were evaluated to define active waking (AW), quiet and paradoxical sleeps (QS, PS)...
September 30, 2016: International Journal of Cardiology
Ying Y Zhao, Jia Weng, Daniel R Mobley, Rui Wang, Younghoon Kwon, Phyllis C Zee, Pamela L Lutsey, Susan Redline
STUDY OBJECTIVES: Type 3 home sleep apnea tests may underestimate the apnea-hypopnea index (AHI) due to overestimation of total sleep time (TST). We aimed to evaluate the effect of manual editing of the total recording time (TRT) on the TST and AHI. METHODS: Thirty 15-channel in-home polysomnography studies (AHI 0 to 30 events/h) scored using American Academy of Sleep Medicine criteria were rescored by two blinded polysomnologists after data from electroencephalogram, electrooculogram, and electromyogram were masked...
September 29, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Patrick H Finan, Jessica M Richards, Charlene E Gamaldo, Dingfen Han, Jeannie Marie Leoutsakos, Rachel Salas, Michael R Irwin, Michael T Smith
OBJECTIVE: To evaluate the validity of an ambulatory electroencephalographic (EEG) monitor for the estimation of sleep continuity and architecture in healthy adults. METHODS: Healthy, good sleeping participants (N = 14) were fit with both an ambulatory EEG monitor (Sleep Profiler) and a full polysomnography (PSG) montage. EEG recordings were gathered from both devices on the same night, during which sleep was permitted uninterrupted for eight hours. The study was set in an inpatient clinical research suite...
September 29, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
P Schüssler, M Kluge, W Gamringer, T C Wetter, A Yassouridis, M Uhr, R Rupprecht, A Steiger
We reported previously that repetitive intravenous injections of corticotropin-releasing hormone (CRH) around sleep onset prompt depression-like changes in certain sleep and endocrine activity parameters (e.g. decrease of slow-wave sleep during the second half of the night, blunted growth hormone peak, elevated cortisol concentration during the first half of the night). Furthermore a sexual dimorphism of the sleep-endocrine effects of the hormones growth hormone-releasing hormone and ghrelin was observed. In the present placebo-controlled study we investigated the effect of pulsatile administration of 4×50μg CRH on sleep electroencephalogram (EEG) and nocturnal cortisol and GH concentration in young healthy women...
September 28, 2016: Psychoneuroendocrinology
Alexia M Thomas, Michael D Schwartz, Michael D Saxe, Thomas S Kilduff
STUDY OBJECTIVES: Although recent innovations have enabled modification of the rat genome, it is unclear whether enhanced utility of rodents as human disease models will result. We compared EEG and behavioral phenotypes of rats and mice with homozygous deletion of Cntnap2, a gene associated with cortical dysplasia-focal epilepsy (CDFE) and autism spectrum disorders (ASD). METHODS: Male Cntnap2 knockout (KO) and wild-type (WT) rats and male Cntnap2 KO and WT mice were implanted with telemeters to record EEG, EMG, body temperature and locomotor activity...
September 26, 2016: Sleep
Eric Rousseau, Cesar Augusto Melo-Silva, Simon Gakwaya, Frédéric Sériès
We tested the hypothesis that stimulating the genioglossus by repetitive transcranial magnetic stimulation (rTMS) during the ascendant portion of the inspiratory flow of airflow-limited breaths would sustain the recruitment of upper airway dilator muscles over time and improve airway dynamics without arousing obstructive sleep apnea (OSA) patients. In a cross-sectional design, 9 OSA patients underwent a rTMS trial during stable non-rapid eye movement (NREM) sleep. Submental muscle motor threshold (SUBMT) and motor-evoked potential were evaluated during wakefulness and sleep...
September 29, 2016: Journal of Applied Physiology
David Looney, Valentin Goverdovsky, Ivana Rosenzweig, Mary J Morrell, Danilo P Mandic
RATIONALE: To date the only quantifiable measure of neural changes that define sleep is electroencephalography (EEG). Although widely used for clinical testing, scalp-electrode EEG is costly and poorly tolerated by sleeping patients. OBJECTIVES: This is a pilot study to assess the agreement between EEG recordings obtained from a new ear-EEG sensor and those obtained simultaneously from standard scalp electrodes. METHODS: Participants were 4 healthy men, ages 25 to 36 years...
September 29, 2016: Annals of the American Thoracic Society
Laura Bennet, Karinna L Fyfe, Stephanie R Yiallourou, Henriette Merk, Flora Y Wong, Rosemary S C Horne
AIM: Limited two-channel electroencephalography (EEG) and amplitude-integrated EEG (aEEG) monitorings are being increasingly used; however, these measurements have not been compared with polysomnographic monitoring, the gold standard for determining infant sleep states. We aimed to determine the accuracy of two-channel EEG and aEEG recordings in defining sleep states and wakefulness in term infants compared to polysomnographic monitoring. METHODS: Sleep was assessed in eight healthy term born infants (mean: 34 ± 3 days), using simultaneous polysomnography (Compumedics S-Series) and a two-channel EEG monitor (Brainz BRM2)...
September 23, 2016: Acta Paediatrica
Michael D Schwartz, Sarah W Black, Simon P Fisher, Jeremiah B Palmerston, Stephen R Morairty, Marius C Hoener, Thomas S Kilduff
Trace amine-associated receptor 1 (TAAR1) agonists have been shown to have pro-cognitive, antipsychotic-like, anxiolytic, weight-reducing, glucose-lowering and wake-promoting activities. We used Taar1 knockout (KO) and over-expressing (OE) mice and TAAR1 agonists to elucidate the role of TAAR1 in sleep/wake. EEG, EMG, body temperature (Tb) and locomotor activity (LMA) were recorded in Taar1 KO, OE and WT mice. Following a 24 h recording to characterize basal sleep/wake parameters, mice were sleep-deprived (SD) for 6 h...
September 23, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
D Martínez-Vargas, A Valdés-Cruz, V M Magdaleno-Madrigal, R Fernández-Mas, S Almazán-Alvarado
BACKGROUND: The nucleus of the solitary tract (NTS) plays a determinant role in the antiepileptic effects of vagus nerve stimulation (VNS). One mechanism underlying the efficacy of VNS is the induction of cortical changes, detected by electroencephalogram (EEG), which can be mediated by the NTS through its projections to the cerebral nuclei responsible for modulating cortical activity. The effect of the electrical stimulation of the nucleus of the solitary tract (ENTS) on EEG activity and sleep states in freely moving animals is unknown...
August 26, 2016: Brain Stimulation
Sarah L Chellappa, Giulia Gaggioni, Julien Q M Ly, Soterios Papachilleos, Chloé Borsu, Alexandre Brzozowski, Mario Rosanova, Simone Sarasso, André Luxen, Benita Middleton, Simon N Archer, Derk-Jan Dijk, Marcello Massimini, Pierre Maquet, Christophe Phillips, Rosalyn J Moran, Gilles Vandewalle
Several neuropsychiatric and neurological disorders have recently been characterized as dysfunctions arising from a 'final common pathway' of imbalanced excitation to inhibition within cortical networks. How the regulation of a cortical E/I ratio is affected by sleep and the circadian rhythm however, remains to be established. Here we addressed this issue through the analyses of TMS-evoked responses recorded over a 29 h sleep deprivation protocol conducted in young and healthy volunteers. Spectral analyses of TMS-evoked responses in frontal cortex revealed non-linear changes in gamma band evoked oscillations, compatible with an influence of circadian timing on inhibitory interneuron activity...
2016: Scientific Reports
Maria Amat-Foraster, Steven C Leiser, Kjartan F Herrik, Nelly Richard, Claus Agerskov, Christoffer Bundgaard, Jesper F Bastlund, Inge E M de Jong
The 5-HT6 receptor is a promising target for cognitive disorders, in particular for Alzheimer's disease (AD). The high affinity and selective 5-HT6 receptor antagonist idalopirdine (Lu AE58054) is currently in development for mild-moderate AD as adjunct therapy to acetylcholinesterase inhibitors (AChEIs). We studied the effects of idalopirdine alone and in combination with the AChEI donepezil on cortical function using two in vivo electrophysiological methods. Neuronal network oscillations in the frontal cortex were measured during electrical stimulation of the brainstem nucleus pontis oralis (nPO) in the anesthetized rat and by an electroencephalogram (EEG) in the awake, freely moving rat...
September 16, 2016: Neuropharmacology
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