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sleep wake eeg

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https://www.readbyqxmd.com/read/28809834/quantifying-infra-slow-dynamics-of-spectral-power-and-heart-rate-in-sleeping-mice
#1
Laura M J Fernandez, Sandro Lecci, Romain Cardis, Gil Vantomme, Elidie Béard, Anita Lüthi
Three vigilance states dominate mammalian life: wakefulness, non-rapid eye movement (non-REM) sleep, and REM sleep. As more neural correlates of behavior are identified in freely moving animals, this three-fold subdivision becomes too simplistic. During wakefulness, ensembles of global and local cortical activities, together with peripheral parameters such as pupillary diameter and sympathovagal balance, define various degrees of arousal. It remains unclear the extent to which sleep also forms a continuum of brain states-within which the degree of resilience to sensory stimuli and arousability, and perhaps other sleep functions, vary gradually-and how peripheral physiological states co-vary...
August 2, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28794189/time-of-day-influences-on-respiratory-sequelae-following-maximal-electroshock-induced-seizures-in-mice
#2
Benton S Purnell, Michael A Hajek, Gordon F Buchanan
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in refractory epilepsy patients. While specific mechanisms underlying SUDEP are not well understood, evidence suggests most SUDEP occurs due to seizure-induced respiratory arrest. SUDEP also tends to happen at night. While this may be due to circumstances humans find themselves in at night, such as being alone without supervision or sleeping prone, or due to independent influences of sleep state, there are a number of reasons why the night (i...
August 9, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28777180/sleep-wake-disorders-of-childhood
#3
Suresh Kotagal
PURPOSE OF REVIEW: Sleep-wake disorders occur in 10% to 28% of children and differ somewhat in pathophysiology and management from sleep-wake disorders in adults. This article discusses the diagnosis and management of key childhood sleep disorders. RECENT FINDINGS: The role of sleep in memory consolidation and in the facilitation of learning has been increasingly recognized, even at the toddler stage. Cataplexy, a key feature of narcolepsy type 1, may be subtle in childhood and characterized by transient muscle weakness isolated to the face...
August 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28776683/hypercapnia-induced-active-expiration-increases-in-sleep-and-enhances-ventilation-in-unanaesthetized-rats
#4
Isabela P Leirão, Carlos A Silva, Luciane H Gargaglioni, Glauber S F da Silva
Expiration is passive at rest but becomes active through recruitment of abdominal muscles under increased respiratory drive. Hypercapnia-induced active expiration has not been well explored in unanaesthetized rats. We hypothesized that (i) CO2 -evoked active expiration is recruited in a state-dependent manner i.e. differently in sleep or wakefulness and (ii) that recruitment of active expiration enhances ventilation, hence having an important functional role in meeting metabolic demand. To test these hypotheses Wistar rats (280-330 g) were implanted with electrodes for electroencephalography (EEG) and electromyography (EMG) of the neck, diaphragm (DIA) and abdominal (ABD) muscles...
August 3, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28757050/electroencephalographic-cognitive-and-neurochemical-effects-of-ly3130481-cerc-611-a-selective-antagonist-of-tarp-%C3%AE-8-associated-ampa-receptors
#5
Jeffrey M Witkin, Jennifer Li, Gary Gilmour, Stephen N Mitchell, Guy Carter, Scott D Gleason, Wesley F Seidel, Brian J Eastwood, Andrew McCarthy, Warren J Porter, Jon Reel, Kevin M Gardinier, Akihiko S Kato, Keith A Wafford
6-[(1S)-1-[1-[5-(2-hydroxyethoxy)-2-pyridyl]pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one (LY3130481 or CERC-611) is a selective antagonist of AMPA receptors containing transmembrane AMPA receptor regulatory protein (TARP) γ-8. This molecule has been characterized as a potent and efficacious anticonvulsant in an array of acute and chronic epilepsy models in rodents. The present set of experiments was designed to assess the effects of LY3130481 on the electroencephelogram (EEG), cognitive function, and neurochemical outflow...
July 27, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28754605/train-hard-sleep-well-perceived-training-load-sleep-quantity-and-sleep-stage-distribution-in-elite-level-athletes
#6
Melanie Knufinke, Arne Nieuwenhuys, Sabine A E Geurts, Els I S Møst, Kamiel Maase, Maarten H Moen, Anton M L Coenen, Michiel A J Kompier
OBJECTIVES: Sleep is essential for recovery and performance in elite athletes. While it is generally assumed that exercise benefits sleep, high training load may jeopardize sleep and hence limit adequate recovery. To examine this, the current study assessed objective sleep quantity and sleep stage distributions in elite athletes and calculated their association with perceived training load. DESIGN: Mixed-methods. METHODS: Perceived training load, actigraphy and one-channel EEG recordings were collected among 98 elite athletes during 7 consecutive days of regular training...
July 12, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28752060/sleep-onset-uncovers-thalamic-abnormalities-in-patients-with-idiopathic-generalised-epilepsy
#7
Andrew P Bagshaw, Joanne R Hale, Brunno M Campos, David T Rollings, Rebecca S Wilson, Marina K M Alvim, Ana Carolina Coan, Fernando Cendes
The thalamus is crucial for sleep regulation and the pathophysiology of idiopathic generalised epilepsy (IGE), and may serve as the underlying basis for the links between the two. We investigated this using EEG-fMRI and a specific emphasis on the role and functional connectivity (FC) of the thalamus. We defined three types of thalamic FC: thalamocortical, inter-hemispheric thalamic, and intra-hemispheric thalamic. Patients and controls differed in all three measures, and during wakefulness and sleep, indicating disorder-dependent and state-dependent modification of thalamic FC...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28744955/cortical-connectivity-modulation-during-sleep-onset-a-study-via-graph-theory-on-eeg-data
#8
Fabrizio Vecchio, Francesca Miraglia, Maurizio Gorgoni, Michele Ferrara, Francesco Iberite, Placido Bramanti, Luigi De Gennaro, Paolo Maria Rossini
Sleep onset is characterized by a specific and orchestrated pattern of frequency and topographical EEG changes. Conventional power analyses of electroencephalographic (EEG) and computational assessments of network dynamics have described an earlier synchronization of the centrofrontal areas rhythms and a spread of synchronizing signals from associative prefrontal to posterior areas. Here, we assess how "small world" characteristics of the brain networks, as reflected in the EEG rhythms, are modified in the wakefulness-sleep transition comparing the pre- and post-sleep onset epochs...
July 26, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28737503/directional-connectivity-in-the-eeg-is-able-to-discriminate-wakefulness-from-nrem-sleep
#9
Giulia Lioi, Steven L Bell, David C Smith, David M Simpson
A reliable measure of consciousness is of great interest for various clinical applications including sleep studies and the assessment of depth of anaesthesia. A number of measures of consciousness based on the EEG have been proposed in the literature and tested in studies of dreamless sleep, general anaesthesia and disorders of consciousness. However, reliability has remained a persistent challenge. Despite considerable theoretical and experimental effort, the neural mechanisms underlying consciousness remain unclear, but connectivity between brain regions is thought to be disrupted, impairing information flow...
July 24, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28729115/arousal-and-drug-abuse
#10
REVIEW
Francisco J Urbano, Verónica Bisagno, Edgar Garcia-Rill
The reticular activating system (RAS) is not an amorphous region but distinct nuclei with specific membrane properties that dictate their firing during waking and sleep. The locus coeruleus and raphe nucleus fire during waking and slow wave sleep, with the pedunculopontine nucleus (PPN) firing during both waking and REM sleep, the states manifesting arousal-related EEG activity. Two important discoveries in the PPN in the last 10 years are, 1) that some PPN cells are electrically coupled, and 2) every PPN cell manifests high threshold calcium channels that allow them to oscillate at beta/gamma band frequencies...
July 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28724928/on-wakefulness-fluctuations-as-a-source-of-bold-functional-connectivity-dynamics
#11
Ariel Haimovici, Enzo Tagliazucchi, Pablo Balenzuela, Helmut Laufs
Human brain dynamics and functional connectivity fluctuate over a range of temporal scales in coordination with internal states and environmental demands. However, the neurobiological significance and consequences of functional connectivity dynamics during rest have not yet been established. We show that the coarse-grained clustering of whole-brain dynamic connectivity measured with magnetic resonance imaging reveals discrete patterns (dynamic connectivity states) associated with wakefulness and sleep. We validate this using EEG in healthy subjects and patients with narcolepsy and by matching our results with previous findings in a large collaborative database...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28714130/nocturnal-seizures-are-associated-with-more-severe-hypoxemia-and-increased-risk-of-postictal-generalized-eeg-suppression
#12
Véronique Latreille, Myriam Abdennadher, Barbara A Dworetzky, Judith Ramel, David White, Eliot Katz, Marcin Zarowski, Sanjeev Kothare, Milena Pavlova
Patients with epilepsy have 20-fold risk of sudden death when compared to the general population. Uncontrolled seizures is the most consistent risk factor, and death often occurs at night or in relation to sleep. We examined seizure-related respiratory disturbances in sleep versus wakefulness, focusing on periictal oxygen saturation. Respiratory measures were examined in 48 recorded seizures (sleep, n = 23, wake, n = 25) from 20 adult patients with epilepsy. Seizures from sleep were associated with lower saturation, as compared to seizures from wakefulness, both during ictal (sleep median = 90...
July 17, 2017: Epilepsia
https://www.readbyqxmd.com/read/28712436/association-of-symptoms-of-insomnia-and-sleep-parameters-among-kidney-transplant-recipients
#13
Katalin Z Ronai, Andras Szentkiralyi, Alpar S Lazar, Zsolt I Lazar, Istvan Papp, Ferenc Gombos, Rezso Zoller, Maria E Czira, Anett V Lindner, Istvan Mucsi, Robert Bodizs, Miklos Z Molnar, Marta Novak
OBJECTIVE: Insomnia complaints are frequent among kidney transplant (kTx) recipients and are associated with fatigue, depression, lower quality of life and increased morbidity. However, it is not known if subjective insomnia symptoms are associated with objective parameters of sleep architecture. Thus, we analyze the association between sleep macrostructure and EEG activity versus insomnia symptoms among kTx recipients. METHODS: Participants (n1=100) were selected from prevalent adult transplant recipients (n0=1214) followed at a single institution...
August 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28683344/age-related-sleep-nocturnal-tonic-and-tonic-clonic-seizure-clusters-are-underdiagnosed-in-patients-with-dravet-syndrome
#14
Emma Losito, Matthieu Kuchenbuch, Nicole Chemaly, Jacques Laschet, Catherine Chiron, Anna Kaminska, Rima Nabbout
OBJECTIVES: To describe the semiology and EEG characteristics of the age-related pattern of sleep/nocturnal (S/N) seizures in patients with Dravet Syndrome (DS). METHODS: We retrospectively analysed the clinical and EEG data of DS patients followed at our reference centre for Rare Epilepsies. We included patients aged two years and older who fulfilled clinical and EEG criteria of DS (ILAE 1989). Genetic testing for SCN1A was done in all, followed by PCDH19 if this was negative...
July 3, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28651358/rem-sleep-theta-changes-in-frequent-nightmare-recallers
#15
Louis-Philippe Marquis, Tyna Paquette, Cloé Blanchette-Carrière, Gaëlle Dumel, Tore Nielsen
The sleep of individuals suffering from frequent non-traumatic nightmares (NM) could prove useful in uncovering neural mechanisms involved in NM production. Past research has shown enhanced relative 10-14.5Hz activity ('high alpha') during REM sleep in frequent NM recallers, while other findings are consistent with a role for theta activity in REM-dependent memory processing. To replicate and expand upon this study, we computed spectral activity for sleep and wake EEG recordings from 18 frequent NM recallers and 15 control participants...
June 23, 2017: Sleep
https://www.readbyqxmd.com/read/28637659/enduring-effects-of-perinatal-nicotine-exposure-on-murine-sleep-in-adulthood
#16
Jeremy Charles Borniger, Reuben F Don, Ning Zhang, Robert Thomas Boyd, Randy J Nelson
The long-term consequences of early life nicotine exposure are poorly defined. Approximately 8-10% of women report smoking during pregnancy, and this may promote aberrant development in the offspring. To this end, we investigated potential enduring effects of perinatal nicotine exposure on murine sleep and affective behaviors in adulthood (~13-15 weeks of age) in C57Bl6j mice. Mothers received a water bottle containing 200 µg/ml nicotine bitartrate dihydrate in 2% w/v saccharin or pH-matched 2% saccharin with 0...
June 21, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28633091/cyclic-alternating-pattern-and-interictal-epileptiform-discharges-during-morning-sleep-after-sleep-deprivation-in-temporal-lobe-epilepsy
#17
Filippo Sean Giorgi, Michelangelo Maestri, Melania Guida, Luca Carnicelli, Lorenzo Caciagli, Raffaele Ferri, Ubaldo Bonuccelli, Enrica Bonanni
PURPOSE: Sleep deprivation (SD) increases the occurrence of interictal epileptiform discharges (IED) compared to basal EEG in temporal lobe epilepsy (TLE). In adults, EEG after SD is usually performed in the morning after SD. We aimed to evaluate whether morning sleep after SD bears additional IED-inducing effects compared with nocturnal physiological sleep, and whether changes in sleep stability (described by the cyclic alternating pattern-CAP) play a significant role. METHODS: Adult patients with TLE underwent in-lab night polysomnography (n-PSG) and, within 7days from n-PSG, they underwent also a morning EEG after night SD (SD-EEG)...
June 17, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28630298/hypocretin-orexin-is-critical-in-sustaining-theta-gamma-rich-waking-behaviors-that-drive-sleep-need
#18
Anne Vassalli, Paul Franken
Hcrt gene inactivation in mice leads to behavioral state instability, abnormal transitions to paradoxical sleep, and cataplexy, hallmarks of narcolepsy. Sleep homeostasis is, however, considered unimpaired in patients and narcoleptic mice. We find that whereas Hcrt(ko/ko) mice respond to 6-h sleep deprivation (SD) with a slow-wave sleep (SWS) EEG δ (1.0 to 4.0 Hz) power rebound like WT littermates, spontaneous waking fails to induce a δ power reflecting prior waking duration. This correlates with impaired θ (6...
July 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28626013/sleep-disrupts-high-level-speech-parsing-despite-significant-basic-auditory-processing
#19
Shiri Makov, Omer Sharon, Nai Ding, Michal Ben-Shachar, Yuval Nir, Elana Zion Golumbic
The extent to which the sleeping brain processes sensory information remains unclear. This is particularly true for continuous and complex stimuli, such as speech, in which information is organized into hierarchically embedded structures. Recently, novel metrics for assessing the neural representation of continuous speech have been developed, using non-invasive brain recordings. Those were so far tested during wakefulness. Here we investigated, for the first time, the sleeping brain's capacity to process continuous speech at different hierarchical levels, using a newly developed Concurrent Hierarchical Tracking (CHT) approach that can online monitor the neural representation and processing-depth of continuous speech...
June 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28618293/pilot-prospective-study-of-post-surgery-sleep-and-eeg-predictors-of-post-operative-delirium
#20
Joanna L Evans, Jacob W Nadler, Xavier A Preud'homme, Eric Fang, Rommie L Daughtry, Joseph B Chapman, David Attarian, Samuel Wellman, Andrew D Krystal
OBJECTIVE: Delirium is a common post-operative complication associated with significant costs, morbidity, and mortality. We sought sleep/EEG predictors of delirium present prior to delirium symptoms to facilitate developing and targeting therapies. METHODS: Continuous EEG data were obtained in 12 patients post-orthopedic surgery from the day of surgery until delirium assessment on post-operative day 2 (POD2). RESULTS: Diminished total sleep time (r=-0...
May 17, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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