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https://www.readbyqxmd.com/read/28920498/an-update-on-biomarker-discovery-and-use-in-axial-spondyloarthritis
#1
Walter P Maksymowych
Evaluation of diagnosis, disease activity, and risk for joint damage all represent important unmet clinical needs in the management of axial spondyloarthritis that have been explored using biomarkers. Areas Covered: This review used the search terms biomarkers, ankylosing spondylitis, spondyloarthritis, spondyloarthropathy, pathogenesis, genetics, diagnostic tools, prognosis, to explore advances in biomarker development relevant to unmet clinical needs. Expert Commentary: Despite major advances in the identification of genetic risk markers, HLA-B*27 remains the only marker with clinical utility for diagnostic purposes...
September 16, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28916545/serologic-evidence-of-gut-driven-systemic-inflammation-in-juvenile-idiopathic-arthritis
#2
Lampros Fotis, Nurmohammad Shaikh, Kevin W Baszis, Charles M Samson, Raffi Lev-Tzion, Anthony R French, Phillip I Tarr
OBJECTIVE: Accumulating evidence links juvenile idiopathic arthritis (JIA) to nonhost factors such as gut microbes. We hypothesize that children with new-onset JIA have increased intestinal bacterial translocation and circulating lipopolysaccharide (LPS). METHODS: We studied systemic treatment-naive patients with JIA [polyarticular JIA, n = 22, oligoarticular JIA, n = 31, and spondyloarthropathies (SpA), n = 16], patients with established inflammatory bowel disease-related arthritis (IBD-RA, n = 11), and 34 healthy controls...
September 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28898393/is-beh%C3%A3-et-s-disease-a-class-1-opathy-the-role-of-hla-b-51-in-the-pathogenesis-of-beh%C3%A3-et-s-disease
#3
REVIEW
Mark Giza, Danai Koftori, Liye Chen, Paul Bowness
The association between carriage of the HLA-B*51 allele and development of Behçet's Disease (BD) has been known since the early 1970s, but the exact mechanisms responsible for its role in pathogenesis remain much-debated. In an effort to explain the disease process, it has been suggested that BD constitutes one of a newly-termed group of diseases, the 'MHC-I-opathies'. Other MHC-I-opathies' include Ankylosing Spondylitis and other HLA-B*27-associated spondyloarthropathies, and HLA-C*0602-associated skin psoriasis...
September 12, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28894334/spondyloarthropathy-diagnostic-imaging-criteria-for-the-detection-of-sacroiliitis
#4
Moacir Ribeiro de Castro, Sonia de Aguiar Vilela Mitraud, Marina Celli Francisco, Artur da Rocha Corrêa Fernandes, Eloy de Ávila Fernandes
Diagnostic imaging is crucial to the diagnosis and monitoring of spondyloarthropathies. Magnetic resonance imaging is the most relevant tool for the early detection of sacroiliitis, allowing the institution of therapeutic strategies to impede the progression of the disease. This study illustrates the major criteria for a magnetic resonance imaging-based diagnosis of spondyloarthropathy. The cases selected here present images obtained from the medical records of patients diagnosed with sacroiliitis over a two-year period at our facility, depicting the active and chronic, irreversible forms of the disease...
July 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28836748/switching-from-other-biologics-to-zrc3197-adalimumab-biosimilar-in-patients-with-spondyloarthropathy-a-prospective-evaluation-from-real-life-clinical-practice
#5
Sanjiv Kapoor
Tumour necrosis factor inhibitors (TNFi) like Infliximab, Etarnacept and Adalimumab have been successfully studied in controlled clinical trials and are currently recommended in the treatment of patients with spondyloarthropathy (SPA). Significant proportion of patients in clinical studies have, however, failed to achieve a desired clinical response, or, are discontinued from the therapy due to secondary inefficacy or side effects. Therefore, owing to the different molecular structures and routes of administration, switching from one TNFi to another is considered as in important option in SPA patients eligible to receive TNFi therapy...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28836747/clinical-use-of-zrc3197-adalimumab-biosimilar-in-patients-with-inflammatory-arthritis-a-real-life-experience
#6
Banwari Sharma
We present our real-life clinical experience of ZRC3197 (Adalimumab Biosimilar) in Indian patients with inflammatory arthritis [spondyloarthropathy (SPA) and rheumatoid arthritis (RA)]. Medical records of these patients were retrospectively retrieved and analysed at our single centre. All the patients had received biosimilar Adalimumab 40 mg every 15 days for initial 3 months. Post 3 months, an 'on-demand modified dosing approach' was followed, wherein BASDAI/DAS28-guided dose reduction or discontinuation of treatment was done...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28821532/cross-phenotype-association-mapping-of-the-mhc-identifies-genetic-variants-that-differentiate-psoriatic-arthritis-from-psoriasis
#7
John Bowes, James Ashcroft, Nick Dand, Farideh Jalali-Najafabadi, Eftychia Bellou, Pauline Ho, Helena Marzo-Ortega, Philip S Helliwell, Marie Feletar, Anthony W Ryan, David J Kane, Eleanor Korendowych, Michael A Simpson, Jonathan Packham, Ross McManus, Matthew A Brown, Catherine H Smith, Jonathan N Barker, Neil McHugh, Oliver FitzGerald, Richard B Warren, Anne Barton
OBJECTIVES: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis, with a strong heritable component, affecting patients with psoriasis. Here we attempt to identify genetic variants within the major histocompatibility complex (MHC) that differentiate patients with PsA from patients with cutaneous psoriasis alone (PsC). METHODS: 2808 patients with PsC, 1945 patients with PsA and 8920 population controls were genotyped. We imputed SNPs, amino acids and classical HLA alleles across the MHC and tested for association with PsA compared to population controls and the PsC patient group...
August 18, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28814815/spondyloarthropathies-ruminococcus-on-the-horizon-in-arthritic-disease
#8
Lars Vereecke, Dirk Elewaut
No abstract text is available yet for this article.
August 17, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28798229/role-of-technetium-99m-methylene-diphosphonate-spect-ct-in-the-detection-of-sacroiliitis-in-patients-with-spondyloarthropathy-comparison-with-clinical-markers-and-mri
#9
Rahul V Parghane, Baljinder Singh, Aman Sharma, Harmandeep Singh, Paramjit Singh, Anish Bhattacharya
Rationale: To evaluate the role of (99m)Tc-MDP SPECT/CT for the detection of sacroiliitis in spondyloarthopathies (SpA) and comparison with clinical markers and MRI. Methods: A total of 155 diagnosed patients (83M : 72 F; mean age 35.80±12.40 years; range 18-60 years ) with SpA as per the European Spondyloarthropathy Study Group criteria (ESSG) criteria were prospectively included All the patients were subjected to clinical evaluation (using BASDAI scoring), ESR, CRP levels, planar (99m)Tc MDP bone scintigraphy, hybrid SPECT/CT and MRI of the pelvic region...
August 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28749173/mri-assessment-of-sacroiliitis-for-the-diagnosis-of-axial-spondyloarthropathy-comparison-of-fat-saturated-t2-stir-and-contrast-enhanced-sequences
#10
Siyoun Sung, Hyun Su Kim, Jong Won Kwon
OBJECTIVE: To evaluate whether there are significant differences between contrast-enhanced fat-saturated T1 weighted imaging and non-enhanced fat-suppression imaging for diagnosing sacroiliitis in patients with inflammatory back pain. METHODS: 92 patients, consisting of 46 males and 46 females (mean age: 34 years; range: 15-63 years), who met at least 4 out of 5 Assessment in SpondyloArthritis international Society criteria for inflammatory low back pain were enrolled in this study...
September 4, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28748512/cross-cultural-adaptation-and-validation-of-the-chinese-version-of-the-health-assessment-questionnaire-for-the-spondyloarthropathies-haq-s
#11
DeLin Liu, Chen Zhang, Chen Wang, Jiao Liu, DaHe Li, Jia Li, Weidong Xu
The Health Assessment Questionnaire for Spondyloarthropathies (HAQ-S) is a commonly used questionnaire to evaluate function and health status of patients with ankylosing spondylitis (AS). The objective of this study was to cross-culturally adapt the HAQ-S into Chinese and then to evaluate its reliability and validity. The Chinese version of the HAQ-S was obtained with a five-step procedure of translation and cross-cultural adaptation. All invited patients met the New York criteria for AS, and a total of 103 patients finally participated in this study...
July 27, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28742241/cervical-epidural-injection-in-management-of-refractory-pain-and-stiffness-in-spondyloarthropathy-a-case-report-series
#12
Semih Gungor, Rohit Aiyer, Doruk Erkan
In this case report series, we present the management of three patients with cervical epidural steroid injection, who presented with neck pain and stiffness secondary to spondyloarthropathy refractory to conservative management. This article is protected by copyright. All rights reserved.
July 25, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28739431/protocol-optimization-of-sacroiliac-joint-mr-imaging-at-3-tesla-impact-of-coil-design-and-motion-resistant-sequences-on-image-quality
#13
P A Gondim Teixeira, M Bravetti, G Hossu, S Lecocq, D Petit, D Loeuille, A Blum
PURPOSE: To evaluate the impact of coil design and motion-resistant sequences on the quality of sacroiliac magnetic resonance imaging (MRI) examination in patients with spondyloarthropathy. PATIENTS AND METHODS: One hundred and twenty-one patients with suspected sacroiliitis and referred for MRI of the sacroiliac joints were retrospectively evaluated with MRI at 3-Tesla. There were 78 women and 43 men with a mean age of 36.7±11.5 (SD) years (range: 15.8-78.4 years)...
July 21, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28686523/clinical-utility-of-therapeutic-drug-monitoring-in-biological-disease-modifying-anti-rheumatic-drug-treatment-of-rheumatic-disorders-a-systematic-narrative-review
#14
REVIEW
Noortje Van Herwaarden, Bart J F Van Den Bemt, Maike H M Wientjes, Cornelis Kramers, Alfons A Den Broeder
Biological Disease Modifying Anti-Rheumatic Drugs (bDMARDs) have improved the treatment outcomes of inflammatory rheumatic diseases including Rheumatoid Arthritis and spondyloarthropathies. Inter-individual variation exists in (maintenance of) response to bDMARDs. Therapeutic Drug Monitoring (TDM) of bDMARDs could potentially help in optimizing treatment for the individual patient. Areas covered: Evidence of clinical utility of TDM in bDMARD treatment is reviewed. Different clinical scenarios will be discussed, including: prediction of response after start of treatment, prediction of response to a next bDMARD in case of treatment failure of the first, prediction of successful dose reduction or discontinuation in case of low disease activity, prediction of response to dose-escalation in case of active disease and prediction of response to bDMARD in case of flare in disease activity...
August 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28681364/treatment-of-a-case-of-ulcerative-colitis-with-sacroiliitis-using-granulocyte-and-monocyte-adsorption-apheresis
#15
Hitoshi Ichikawa, Jin Imai, Hajime Mizukami, Takayuki Shirai, Norihito Watanabe
In Japan, sacroiliitis is a very rare extraintestinal manifestation in patients with ulcerative colitis (UC), and it typically presents with intestinal symptoms. Radiography is used for diagnosis, and reveals erosions, sclerosis, and ankylosis, but magnetic resonance imaging is more useful for early detection. The treatment of spondyloarthropathy such as sacroiliitis and spondylitis includes physiotherapy, nonsteroidal anti-inflammatory drugs, sulfasalazine, and immunomodulators. In patients intolerant or cases refractory to these treatments, anti-tumor necrosis factor agents are recommended...
July 20, 2017: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/28666464/animal-models-of-rheumatoid-pain-experimental-systems-and-insights
#16
REVIEW
Bradford D Fischer, Adeshina Adeyemo, Michael E O'Leary, Andrea Bottaro
Severe chronic pain is one of the hallmarks and most debilitating manifestations of inflammatory arthritis. It represents a significant problem in the clinical management of patients with common chronic inflammatory joint conditions such as rheumatoid arthritis, psoriatic arthritis and spondyloarthropathies. The functional links between peripheral inflammatory signals and the establishment of the neuroadaptive mechanisms acting in nociceptors and in the central nervous system in the establishment of chronic and neuropathic pain are still poorly understood, representing an area of intense study and translational priority...
June 30, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28662824/matrix-metalloproteinases-and-synovial-joint-pathology
#17
Charles J Malemud
Matrix metalloproteinases (MMPs) are zinc-dependent enzymes. These enzymes play a critical role in the destruction of articular cartilage in rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic arthritis (PsA), and the spondyloarthropathies. MMP gene expression is upregulated in these synovial joint pathologies in response to elevated levels of proinflammatory cytokines and soluble mediators such as tumor necrosis factor-α, interleukin-1 (IL-1), IL-6, IL-17, and interferon-γ. These molecules are capable of activating the mitogen-activated protein kinase and Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways by binding the cytokine to their respective receptors on immune cells, macrophages, chondrocytes, synoviocytes, and osteocytes leading to increased synthesis of MMPs...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/28660909/spondyloarthropathies-mif-drives-inflammation-and-bone-formation-in-as
#18
Sarah Onuora
No abstract text is available yet for this article.
August 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28622455/intestinal-metabolites-are-profoundly-altered-in-the-context-of-hla-b27-expression-and-functionally-modulate-disease-in-a-rat-model-of-spondyloarthritis
#19
Mark Asquith, Sean Davin, Patrick Stauffer, Claire Michell, Cathleen Janowitz, Phoebe Lin, Joe Ensign-Lewis, Jason M Kinchen, Dennis R Koop, James T Rosenbaum
OBJECTIVE: HLA-B27-associated spondyloarthritides are associated with an altered intestinal microbiota and bowel inflammation. We undertook this study to identify HLA-B27-dependent changes in both host and microbial metabolites in the HLA-B27/β2 -microglobulin (β2 m)-transgenic rat and to determine whether microbiota-derived metabolites could impact disease in this major model of spondyloarthritis. METHODS: Cecal contents were collected from Fischer 344 33-3 HLA-B27/β2 m-transgenic rats and wild-type controls at 6 weeks (before disease) and 16 weeks (with active bowel inflammation)...
June 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28592895/spondyloarthropathies-targeting-il-17-in-refractory-psa
#20
Jessica McHugh
No abstract text is available yet for this article.
July 2017: Nature Reviews. Rheumatology
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