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successive sequential processing

Selcuk Kayir, Hulya Ulusoy, Guvenc Dogan
Background/aims Sedation is one of the most important components of intensive care unit (ICU) in patients who are mechanically ventilated at intensive care conditions. As a result of sedation and analgesia in the intensive care unit, the patient is to be awakened a comfortable and easy process. The aim of the study is to demonstrate the effects of day-time sedation interruptions in intensive care patients. Material and methods We made a retrospective review of 100 patients who were monitored, mechanically ventilated and treated at our intensive care unit between January 2008 and January 2013...
January 13, 2018: Curēus
Tochukwu C Okwuosa, Cindy Soares, Verena Golwitzer, Rober Habashy, Peter Timmins, Mohamed A Alhnan
A method for the production of liquid capsules with the potential of modifying drug dose and release is presented. For the first time, the co-ordinated use of fused deposition modelling (FDM), 3D printing and liquid dispensing to fabricate individualised dosage form on demand in a fully automated fashion has been demonstrated. Polymethacrylate shells (Eudragit EPO and RL) for immediate and extended release were fabricated using FDM 3D printing and simultaneously filled using a computer-controlled liquid dispenser loaded with model drug solution (theophylline) or suspension (dipyridamole)...
March 11, 2018: European Journal of Pharmaceutical Sciences
Kyeong-Bae Seo, In-Hwan Lee, Jaeho Lee, Inho Choi, Tae-Lim Choi
Herein, we report a highly efficient Suzuki-Miyaura catalyst-transfer polycondensation (SCTP) of 3-alkylthiophenes using bench-stable but highly active Buchwald dialkylbiarylphospine Pd G3 precatalysts and N-methylimidodiacetic (MIDA)-boronate monomers. Initially, the feasibility of the catalyst-transfer process was examined by screening various dialkylbiarylphospine-Pd(0) species. After optimizing a small molecule model reaction, we identified both RuPhos and SPhos Pd G3 precatalysts as excellent catalyst systems for this purpose...
March 9, 2018: Journal of the American Chemical Society
Satya Pal Verma, Biswajit Sarkar
Flux decline due to membrane fouling by surfactant micelles is the major problem limiting the use of micellar enhanced ultrafiltration (MEUF) for the treatment of wastewater. Understanding of underlying mechanisms of membrane fouling, adsorption kinetics and adsorption isotherm are very important for the successful application of MEUF studies. In the present study, an unsteady state model considering sequential occurrence of complete pore blocking and gel layer formation was proposed for explaining flux decline behavior during rhamnolipid based MEUF for simultaneous removal of Cd+2 and p-cresol from aqueous solution under batch concentration mode...
February 28, 2018: Journal of Environmental Management
Bernhard Bereiter, Kenji Kawamura, Jeffrey P Severinghaus
RATIONALE: The global ocean constitutes the largest heat buffer in the global climate system, but little is known about its past changes. The isotopic and elemental ratios of heavy noble gases (krypton and xenon), together with argon and nitrogen in trapped air from ice cores can be used to reconstruct past mean ocean temperatures (MOTs). Here we introduce two successively developed methods to measure these parameters with a sufficient precision to provide new constraints on past MOT changes...
March 3, 2018: Rapid Communications in Mass Spectrometry: RCM
Alexander L M Siegel, Alan D Castel
Older adults typically experience memory impairments for verbal and visuospatial episodic information, which are most pronounced for associative information. Although some age-related verbal memory deficits may be reduced by selectively focusing on high-value item information, the binding of items to locations in visuospatial memory involves different processes that are impaired in older adults. In the current study, we examined whether age-related impairment in visuospatial binding could be alleviated by strategic focus on important information and whether varying study time and presentation formats would affect such selectivity...
February 2018: Psychology and Aging
Xin Li, Jin Wang, Richard Y K Fung
During the appointment booking process in out-patient departments, the level of patient satisfaction can be affected by whether or not their preferences can be met, including the choice of physicians and preferred time slot. In addition, because the appointments are sequential, considering future possible requests is also necessary for a successful appointment system. This paper proposes a Markov decision process model for optimizing the scheduling of sequential appointments with patient preferences. In contrast to existing models, the evaluation of a booking decision in this model focuses on the extent to which preferences are satisfied...
February 23, 2018: Artificial Intelligence in Medicine
Maria Andreadaki, Eric Hanssen, Elena Deligianni, Cyrille Claudet, Kai Wengelnik, Vanessa Mollard, Geoffrey I McFadden, Manouk Abkarian, Catherine Braun-Breton, Inga Siden-Kiamos
Malaria parasites alternate between intracellular and extracellular stages and successful egress from the host cell is crucial for continuation of the life cycle. We investigated egress of Plasmodium berghei gametocytes, an essential process taking place within a few minutes after uptake of a blood meal by the mosquito. Egress entails the rupture of two membranes surrounding the parasite: the parasitophorous vacuole membrane (PVM), and the red blood cell membrane (RBCM). High-speed video microscopy of 56 events revealed that egress in both genders comprises four well-defined phases, although each event is slightly different...
February 23, 2018: Scientific Reports
Andreas Nickisch, Franziska Werner, Christiane Kiese-Himmel
OBJECTIVE: In a controlled group comparison it was shown for 2nd, 3th and 4th graders that children with auditory processing disorders (APD) could be distinguished from those without (Non-APD) by three to four diagnostic tools. The hit rate was 93.6 % resp. 97.5 % 1, 2. The current study investigated whether such a separation is also possible in first graders. MATERIAL AND METHODS: Performance of 77 first graders in two clinically and diagnostically confirmed groups (n = 40 with APD, mean age: 6...
February 15, 2018: Laryngo- Rhino- Otologie
Kyle W Killebrew, Gennadiy Gurariy, Candace E Peacock, Marian E Berryhill, Gideon P Caplovitz
Why are some visual stimuli remembered, whereas others are forgotten? A limitation of recognition paradigms is that they measure aggregate behavioral performance and/or neural responses to all stimuli presented in a visual working memory (VWM) array. To address this limitation, we paired an electroencephalography (EEG) frequency-tagging technique with two full-report VWM paradigms. This permitted the tracking of individual stimuli as well as the aggregate response. We recorded high-density EEG (256 channel) while participants viewed four shape stimuli, each flickering at a different frequency...
February 14, 2018: Cognitive, Affective & Behavioral Neuroscience
Araiz Gallo, Adrian Valli, María Calvo, Juan Antonio García
Accurate assembly of viral particles in the potyvirus Plum pox virus (PPV) has been shown to depend on the contribution of the multifunctional viral protein HCPro. In this study, we show that other viral factors, in addition to the capsid protein (CP) and HCPro, are necessary for the formation of stable PPV virions. The CP produced in Nicotiana benthamiana leaves from a subviral RNA termed LONG, which expresses a truncated polyprotein that lacks P1 and HCPro, together with HCPro supplied in trans , was assembled into virus like particles and remained stable after in vitro incubation...
February 14, 2018: Journal of Virology
Hayati Samsudin, Rafael Auras, Gary Burgess, Kirk Dolan, Herlinda Soto-Valdez
A two-step solution based on the boundary conditions of Crank's equations for mass transfer in a film was developed. Three driving factors, the diffusion (D), partition (Kp,f) and convective mass transfer coefficients (h), govern the sorption and/or desorption kinetics of migrants from polymer films. These three parameters were simultaneously estimated. They provide in-depth insight into the physics of a migration process. The first step was used to find the combination of D, Kp,f and h that minimized the sums of squared errors (SSE) between the predicted and actual results...
March 2018: Food Research International
Viacheslav V Danilov, Igor P Skirnevskiy, Olga M Gerget, Egor E Shelomentcev, Dmitrii Yu Kolpashchikov, Nikolay V Vasilyev
The present study aimed to present a workflow algorithm for automatic processing of 2D echocardiography images. The workflow was based on several sequential steps. For each step, we compared different approaches. Epicardial 2D echocardiography datasets were acquired during various open-chest beating-heart surgical procedures in three porcine hearts. We proposed a metric called the global index that is a weighted average of several accuracy coefficients, indices and the mean processing time. This metric allows the estimation of the speed and accuracy for processing each image...
February 10, 2018: International Journal of Cardiovascular Imaging
Saheed O Ajayi, Lukumon O Oyedele
Albeit the understanding that construction waste is caused by activities ranging from all stages of project delivery process, research efforts have been concentrated on design and construction stages, while the possibility of reducing waste through materials procurement process is widely neglected. This study aims at exploring and confirming strategies for achieving waste-efficient materials procurement in construction activities. The study employs sequential exploratory mixed method approach as its methodological framework, using focus group discussion, statistical analysis and structural equation modelling...
February 6, 2018: Waste Management
Seok Young Ji, Wonsuk Choi, Hoon-Young Kim, Jin-Woo Jeon, Sung-Hak Cho, Won Seok Chang
The development of printing technologies has enabled the realization of electric circuit fabrication on a flexible substrate. However, the current technique remains restricted to single-layer patterning. In this paper, we demonstrate a fully solution-processable patterning approach for multi-layer circuits using a combined method of laser sintering and ablation. Selective laser sintering of silver (Ag) nanoparticle-based ink is applied to make conductive patterns on a heat-sensitive substrate and insulating layer...
February 9, 2018: Materials
Aaron R Lyon, Kelly Whitaker, Jill Locke, Clayton R Cook, Kevin M King, Mylien Duong, Chayna Davis, Mark D Weist, Mark G Ehrhart, Gregory A Aarons
BACKGROUND: Integrated healthcare delivered by work groups in nontraditional service settings is increasingly common, yet contemporary implementation frameworks typically assume a single organization-or organizational unit-within which system-level processes influence service quality and implementation success. Recent implementation frameworks predict that inter-organizational alignment (i.e., similarity in values, characteristics, activities related to implementation across organizations) may facilitate the implementation of evidence-based practices (EBP), but few studies have evaluated this premise...
February 7, 2018: Implementation Science: IS
Aditi P Singh, Diego Adrianzen Herrera, Yifei Zhang, Roman Perez-Soler, Haiying Cheng
Squamous cell lung cancer (SQCLC) is the second most common subtype of non-small cell lung cancer (NSCLC) and has limited therapeutic options. Its development is likely a result of a multistep process in response to chronic tobacco exposure, involving sequential metaplasia, dysplasia and invasive carcinoma. Its complex genomic landscape has recently been revealed but no driver mutations have been validated that could lead to molecularly targeted therapy as have emerged in lung adenocarcinoma. Few preclinical murine models exist for testing and developing novel therapeutics in SQCLC...
February 2, 2018: Expert Opinion on Drug Discovery
Muhammad Adnan, Jae Kwan Lee
A novel, sequential method of dip-coating a ZnO covered mesoporous TiO2 electrode was performed using a non-halide lead precursor in an aqueous system to form a nanoscale perovskite film. The introduction of a ZnO interfacial layer induced significant adsorption in the non-halide lead precursor system. An efficient successive solid-state ion exchange and reaction process improved the morphology, crystallinity, and stability of perovskite solar cells. Improved surface coverage was achieved using successive ionic layer adsorption and reaction processes...
February 1, 2018: Scientific Reports
Xuan Cheng, Paul A Umina, Ary A Hoffmann, Dominic Reisig
In the evolution of phytophagous arthropods, adaptation to a single type of host plant is generally assumed to lead to a reduction in fitness on other host plant types, resulting in increasing host specialization. While this process is normally considered to be genetically based, short-term effects acting within one generation (plasticity) or across two generations (cross-generation variation) could also play a role. Here, we test these effects in the redlegged earth mite, Halotydeus destructor (Tucker) (Prostigmata: Penthaleidae), a major agricultural pest of multiple crop plants...
January 29, 2018: Journal of Economic Entomology
Jack S Fogarty, Robert J Barry, Frances M De Blasio, Genevieve Z Steiner
Previous research suggests that young adults do not need active and effortful inhibition to successfully complete the auditory equiprobable go/no-go task, a view that was incorporated into Barry and De Blasio's sequential processing schema for this task. However, recent evidence in children suggests that view could be incorrect. The present research aims to clarify the functionality of the N2 and P3 subcomponents within the proposed schema, assessing the role of inhibition in this task. To optimize the quantification of the N2 and P3 subcomponents, separate temporal PCAs were applied to the go/no-go ERP data from 40 young adults...
January 31, 2018: Psychophysiology
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