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https://www.readbyqxmd.com/read/29157274/evaluating-implementation-of-the-world-health-organization-s-strategic-approach-to-strengthening-sexual-and-reproductive-health-policies-and-programs-to-address-unintended-pregnancy-and-unsafe-abortion
#1
Shusmita Rashid, Julia E Moore, Caitlyn Timmings, Joshua P Vogel, Bela Ganatra, Dina N Khan, Radha Sayal, A Metin Gülmezoglu, Sharon E Straus
BACKGROUND: We conducted a process evaluation to assess how the World Health Organization's (WHO) Strategic Approach to strengthening sexual and reproductive health policies and programs ("the SA") was used in 15 countries that requested WHO's technical support in addressing unintended pregnancy and unsafe abortion. The SA is a three-stage planning, policy, and program implementation process. We used the social ecological model (SEM) to analyze the contextual factors that influenced SA implementation...
November 21, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29155751/dissection-and-immunofluorescent-staining-of-mushroom-body-and-photoreceptor-neurons-in-adult-drosophila-melanogaster-brains
#2
Seth M Kelly, Alexandra Elchert, Michael Kahl
Nervous system development involves a sequential series of events that are coordinated by several signaling pathways and regulatory networks. Many of the proteins involved in these pathways are evolutionarily conserved between mammals and other eukaryotes, such as the fruit fly Drosophila melanogaster, suggesting that similar organizing principles exist during the development of these organisms. Importantly, Drosophila has been used extensively to identify cellular and molecular mechanisms regulating processes that are required in mammals including neurogenesis, differentiation, axonal guidance, and synaptogenesis...
November 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29109776/sequential-delivery-of-cyclopeptide-ra-v-and-doxorubicin-for-combination-therapy-on-resistant-tumor-and-in-situ-monitoring-of-cytochrome-c-release
#3
Huachao Chen, Yurong Wang, Yongrong Yao, Shenglin Qiao, Hao Wang, Ninghua Tan
A programmed drug delivery system that can achieve sequential release of multiple therapeutics under different stimulus holds great promise to enhance the treatment efficacy and overcome multi-drug resistance (MDR) in tumor. Herein, multi-organelle-targeted and pH/ cytochrome c (Cyt c) dual-responsive nanoparticles were designed for combination therapy on resistant tumor. In this system (designated DGLipo NPs), doxorubicin (Dox) was intercalated into the DNA duplex containing a Cyt c aptamer, which subsequently loaded in the dendrigraftpoly-L-lysines (DGL) cores of DGLipo NPs, while cyclopeptide RA-V was doped into the pH-sensitive liposomal shells...
2017: Theranostics
https://www.readbyqxmd.com/read/29096876/a-training-program-for-nurse-scientists-to-promote-intervention-translation
#4
Sheila Judge Santacroce, Jennifer Leeman, Mi-Kyung Song
BACKGROUND: To reduce the burden of chronic illness, prevention and management interventions must be efficacious, adopted and implemented with fidelity, and reach those at greatest risk. Yet, many research-tested interventions are slow to translate into practice. PURPOSE: This paper describes how The University of North Carolina at Chapel Hill School of Nursing's NINR-funded institutional pre- and postdoctoral research-training program is addressing the imperative to speed knowledge translation across the research cycle...
September 19, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/29076295/calcium-phosphate-collagen-scaffold-with-aligned-pore-channels-for-enhanced-osteochondral-regeneration
#5
Yun-Jeong Seong, In-Gu Kang, Eun-Ho Song, Hyoun-Ee Kim, Seol-Ha Jeong
This study reports the development of a bilayered scaffold with aligned channels produced via a sequential coextrusion and unidirectional freezing process to facilitate upward bone-marrow stem-cell migration. The biomimetic scaffold with collagen and biphasic calcium phosphate (BCP) layers is successfully fabricated with matching of the cartilage and bone layers. The aligned structure results in an enhancement of the compressive strength, and the channels enable tight anchoring of the collagen layers on the BCP scaffolds compared with a randomly structured porous scaffold...
October 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29073543/a-simple-fluorescent-probe-for-the-fast-sequential-detection-of-copper-and-biothiols-based-on-a-benzothiazole-derivative
#6
Youming Shen, Xiangyang Zhang, Chunxiang Zhang, Youyu Zhang, Junling Jin, Haitao Li
A simple benzothiazole fluorescent chemosensor was developed for the fast sequential detection of Cu(2+) and biothiols through modulating the excited-state intramolecular proton transfer (ESIPT) process. The compound 1 exhibits highly selective and sensitive fluorescence "on-off" recognition to Cu(2+) with a 1:1 binding stoichiometry by ESIPT hinder. The in situ generated 1-Cu(2+) complex can serve as an "on-off" fluorescent probe for high selectivity toward biothiols via Cu(2+) displacement approach, which exerts ESIPT recovery...
September 28, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29052186/a-rapid-and-efficient-chip-protocol-to-profile-chromatin-binding-proteins-and-epigenetic-modifications-in-arabidopsis
#7
Bénédicte Desvoyes, Zaida Vergara, Joana Sequeira-Mendes, Sofia Madeira, Crisanto Gutierrez
Chromatin immunoprecipitation (ChIP) is a widely used and very powerful procedure to identify the proteins that are associated with the DNA to regulate developmental processes. These proteins can be transcription factors, or specific histone variants and modified histones, which are all crucial for gene regulation. In order to obtain reliable results, ChIP must be carried out under highly reproducible conditions. Here, we describe a simple and fast ChIP protocol adapted for Arabidopsis seedlings, which can serve as a basis for other species, organs or more sophisticated procedures, such as the sequential ChIP...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29051929/fully-chip-embedded-automation-of-a-multi-step-lab-on-a-chip-process-using-a-modularized-timer-circuit
#8
Junsu Kang, Donghyeon Lee, Young Jin Heo, Wan Kyun Chung
For highly-integrated microfluidic systems, an actuation system is necessary to control the flow; however, the bulk of actuation devices including pumps or valves has impeded the broad application of integrated microfluidic systems. Here, we suggest a microfluidic process control method based on built-in microfluidic circuits. The circuit is composed of a fluidic timer circuit and a pneumatic logic circuit. The fluidic timer circuit is a serial connection of modularized timer units, which sequentially pass high pressure to the pneumatic logic circuit...
November 7, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29035508/three-dimensionally-hierarchical-ni-ni3s2-s-cathode-for-lithium-sulfur-battery
#9
Zhe Li, Shiguo Zhang, Jiaheng Zhang, Miao Xu, Ryoichi Tatara, Kaoru Dokko, Masayoshi Watanabe
Lithium-sulfur (Li-S) batteries have attracted interest as a promising energy-storage technology due to their overwhelming advantages such as high energy density and low cost. However, their commercial success is impeded by deterioration of sulfur utilization, significant capacity fade, and poor cycle life, which are principally originated from the severe shuttle effect in relation to the dissolution and migration of lithium polysulfides. Herein, we proposed an effective and facile strategy to anchor the polysulfides and improve sulfur loading by constructing a three-dimensionally hierarchical Ni/Ni3S2/S cathode...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29035355/sequential-bottom-up-assembly-of-mechanically-stabilized-synthetic-cells-by-microfluidics
#10
Marian Weiss, Johannes Patrick Frohnmayer, Lucia Theresa Benk, Barbara Haller, Jan-Willi Janiesch, Thomas Heitkamp, Michael Börsch, Rafael B Lira, Rumiana Dimova, Reinhard Lipowsky, Eberhard Bodenschatz, Jean-Christophe Baret, Tanja Vidakovic-Koch, Kai Sundmacher, Ilia Platzman, Joachim P Spatz
Compartments for the spatially and temporally controlled assembly of biological processes are essential towards cellular life. Synthetic mimics of cellular compartments based on lipid-based protocells lack the mechanical and chemical stability to allow their manipulation into a complex and fully functional synthetic cell. Here, we present a high-throughput microfluidic method to generate stable, defined sized liposomes termed 'droplet-stabilized giant unilamellar vesicles (dsGUVs)'. The enhanced stability of dsGUVs enables the sequential loading of these compartments with biomolecules, namely purified transmembrane and cytoskeleton proteins by microfluidic pico-injection technology...
October 16, 2017: Nature Materials
https://www.readbyqxmd.com/read/29019943/some-hardware-and-instrumentation-aspects-of-the-development-of-an-automation-system-for-jar-tests-in-drinking-water-treatment
#11
Antonio José Calderón, Isaías González
The so-called Jar Test (JT) plays a vital role in the drinking water and wastewater treatments for establishing the dosage of flocculants and coagulant. This test is a well-proved laboratory instrumental procedure performed by trained personnel. In this work, a completely novel system for the automation and monitoring of a JT devoted to drinking water treatment is presented. It has been implemented using an industrial programmable controller and sensors and instruments specifically selected for this purpose...
October 11, 2017: Sensors
https://www.readbyqxmd.com/read/28982151/gmdptoolbox-a-matlab-library-for-designing-spatial-management-policies-application-to-the-long-term-collective-management-of-an-airborne-disease
#12
Marie-Josée Cros, Jean-Noël Aubertot, Nathalie Peyrard, Régis Sabbadin
Designing management policies in ecology and agroecology is complex. Several components must be managed together while they strongly interact spatially. Decision choices must be made under uncertainty on the results of the actions and on the system dynamics. Furthermore, the objectives pursued when managing ecological systems or agroecosystems are usually long term objectives, such as biodiversity conservation or sustainable crop production. The framework of Graph-Based Markov Decision Processes (GMDP) is well adapted to the qualitative modeling of such problems of sequential decision under uncertainty...
2017: PloS One
https://www.readbyqxmd.com/read/28976735/wafer-scale-integration-of-highly-uniform-and-scalable-mos2-transistors
#13
Yonghun Kim, Ah Ra Kim, Guoqing Zhao, Sun Young Choi, Soo Cheol Kang, Sung Kwan Lim, Kang Eun Lee, Jucheol Park, Byoung Hun Lee, Myung Gwan Hahm, Dong-Ho Kim, Jungheum Yun, Kyu Hwan Lee, Byungjin Cho
Molybdenum disulfide with atomic-scale flatness has application potential in high-speed and low-power logic devices owing to its scalability and intrinsic high mobility. However, to realize viable technologies based on two-dimensional materials, techniques that enable their large-area growth with high quality and uniformity on wafer cale is a prerequisite. Here, we provide a route toward highly uniform growth of a wafer-scale, four-layered MoS2 film on a 2 in. substrate via a sequential process consisting of the deposition of a molybdenum trioxide precursor film by sputtering followed by postsulfurization using a chemical vapor deposition process...
October 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28967752/synthesis-of-polycyclic-benzo-b-indolo-3-2-1-de-acridines-via-sequential-allenylation-diels-alder-cyclization-and-hydrogen-migration-reaction
#14
Yulei Zhao, Yang Yuan, Xiaoyu Wang, Yanzhong Li
A novel methodology for stereoselective synthesis of benzo[b]indolo[3,2,1-de]acridines through the tandem reaction of propargylic compounds with organoboron is described, and only one diastereoisomer was obtained. The sequential procedure was triggered by Pd(0)-catalyzed allenylation of propargyl carbonate. Then, Diels-Alder cyclization and hydrogen migration processes proceeded successively to furnish the polycyclic target molecules. Control reactions suggested the base (Cs2CO3) was indispensable for the hydrogen migration...
October 9, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28965305/conversion-of-sago-metroxylon-sagu-pith-waste-to-fermentable-sugars-via-a-facile-depolymerization-process
#15
Suh Cem Pang, Lee Ken Voon, Suk Fun Chin
The conversion of starchy sago (Metroxylon sagu) pith waste (SPW), a lignocellulosic biomass waste, to fermentable sugars under mild conditions had been successfully demonstrated. The optimum depolymerization of SPW was achieved at 2 wt% sample loading which was catalyzed by 100 mM of oxalic acid in the presence of 25 wt% NaCl solution at 110 °C for 3 h. Up to 97% SPW sample was being converted into fermentable sugars with limited formation of by-products after two sequential depolymerization cycles. Both reaction temperature and concentration of oxalic acid were crucial parameters for the depolymerization of SPW which exhibited a high selectivity for the production of glucose over other reducing sugars...
September 30, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28962748/synthesis-and-melt-processing-of-cellulose-esters-for-preparation-of-thermoforming-materials-and-extended-drug-release-tablets
#16
Sanna Virtanen, Riku Talja, Sauli Vuoti
Using softwood pulp as the starting material, the synthesis of regioselectively substituted mixed cellulose esters with varying degree of substitution and ratio of short/long chains was successfully completed. The structures of the cellulose esters were characterised. The impact of the structural changes and the degree of substitution of the cellulose esters on thermal properties and processability were investigated. The study shows that the sequential esterification is a promising modification route for cellulose to improve its thermal processability and mechanical properties without the use of external processing aids such as plasticisers...
December 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28959271/rapid-development-and-characterization-of-chromosome-specific-translocation-line-of-thinopyrum-elongatum-with-improved-dough-strength
#17
Aman Kumar, Monika Garg, Navneet Kaur, Venkatesh Chunduri, Saloni Sharma, Swati Misser, Ashish Kumar, Hisashi Tsujimoto, Quan-Wen Dou, Raj K Gupta
The protein content and its type are principal factors affecting wheat (Triticum aestivum) end product quality. Among the wheat proteins, glutenin proteins, especially, high molecular weight glutenin subunits (HMW-GS) are major determinants of processing quality. Wheat and its primary gene pool have limited variation in terms of HMW-GS alleles. Wild relatives of wheat are an important source of genetic variation. For improvement of wheat processing quality its wild relative Thinopyrum elongatum with significant potential was utilized...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28946407/ultrasound-assisted-synthesis-of-stable-oil-in-milk-emulsion-study-of-operating-parameters-and-scale-up-aspects
#18
Leena Patil, Parag R Gogate
In the present work, application of ultrasound and stirring individually or in combination for improved emulsification of turmeric oil in skimmed milk has been investigated. The effect of different operating parameters/strategies such as addition of surfactant, sodium dodecyl sulfate (SDS), at different concentrations, quantity of oil phase, applied power, sonication time and duty cycle on the droplet size have been investigated. The stability of emulsion was analyzed in terms of the fraction of the emulsion that remains stable for a period of 28days...
January 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28941792/multidisciplinary-evaluation-of-an-emergency-department-nurse-navigator-role-a-mixed-methods-study
#19
Melanie Jessup, Paul Fulbrook, Frances B Kinnear
AIM: To utilise multidisciplinary staff feedback to assess their perceptions of a novel emergency department nurse navigator role and to understand the impact of the role on the department. BACKGROUND: Prolonged emergency department stays impact patients, staff and quality of care, and are linked to increased morbidity and mortality. One innovative strategy to facilitate patient flow is the navigator: a nurse supporting staff in care delivery to enhance efficient, timely movement of patients through the department...
September 20, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/28934693/enzyme-classification-using-multiclass-support-vector-machine-and-feature-subset-selection
#20
Debasmita Pradhan, Sudarsan Padhy, Biswajit Sahoo
Proteins are the macromolecules responsible for almost all biological processes in a cell. With the availability of large number of protein sequences from different sequencing projects, the challenge with the scientist is to characterize their functions. As the wet lab methods are time consuming and expensive, many computational methods such as FASTA, PSI-BLAST, DNA microarray clustering, and Nearest Neighborhood classification on protein-protein interaction network have been proposed. Support vector machine is one such method that has been used successfully for several problems such as protein fold recognition, protein structure prediction etc...
August 31, 2017: Computational Biology and Chemistry
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