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https://www.readbyqxmd.com/read/28819917/polyglandular-autoimmune-syndromes
#1
REVIEW
G J Kahaly, L Frommer
BACKGROUND: In recent years, scientific knowledge pertaining to the rare ORPHAN polyglandular autoimmune syndrome (registered code ORPHA 282196) has accumulated. OBJECTIVE: To offer current demographic, clinical, serological and immunogenic data on PAS. METHODS: Review of the pertinent and current literature. RESULTS: Polyglandular autoimmune syndromes (PAS) are multifactorial diseases with at least two coexisting autoimmune-mediated endocrinopathies...
August 17, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28807089/supramolecular-based-ultrasonic-assisted-dispersion-solidification-liquid-liquid-microextraction-of-copper-and-cobalt-prior-to-their-flame-atomic-absorption-spectrometry-determination
#2
Ardeshir Shokrollahi, Foroogh Ebrahimi
In the present work, a simple, efficient, and environmentally friendly method was proposed for the simultaneous preconcentration and determination of minute quantities of copper and cobalt in water samples and serum by a supramolecular-based ultrasonic-assisted dispersion solidification liquid–liquid microextraction (DSLLME) procedure coupled with flame atomic absorption spectrometry. The procedure is based on the DSLLME of copper and cobalt with decanoic acid–tetrahydrofuran supramolecular solvent (SUPRAS) in the presence of sodium diethyldithiocarbamate, as the complexing agent...
August 15, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28799274/bayesian-joint-modeling-of-bivariate-longitudinal-and-competing-risks-data-an-application-to-study-patient-ventilator-asynchronies-in-critical-care-patients
#3
Montserrat Rué, Eleni-Rosalina Andrinopoulou, Danilo Alvares, Carmen Armero, Anabel Forte, Lluis Blanch
Mechanical ventilation is a common procedure of life support in intensive care. Patient-ventilator asynchronies (PVAs) occur when the timing of the ventilator cycle is not simultaneous with the timing of the patient respiratory cycle. The association between severity markers and the events death or alive discharge has been acknowledged before, however, little is known about the addition of PVAs data to the analyses. We used an index of asynchronies (AI) to measure PVAs and the SOFA (sequential organ failure assessment) score to assess overall severity...
August 11, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/28798742/preservation-and-significance-of-extracellular-dna-in-ferruginous-sediments-from-lake-towuti-indonesia
#4
Aurèle Vuillemin, Fabian Horn, Mashal Alawi, Cynthia Henny, Dirk Wagner, Sean A Crowe, Jens Kallmeyer
Extracellular DNA is ubiquitous in soil and sediment and constitutes a dominant fraction of environmental DNA in aquatic systems. In theory, extracellular DNA is composed of genomic elements persisting at different degrees of preservation produced by processes occurring on land, in the water column and sediment. Extracellular DNA can be taken up as a nutrient source, excreted or degraded by microorganisms, or adsorbed onto mineral matrices, thus potentially preserving information from past environments. To test whether extracellular DNA records lacustrine conditions, we sequentially extracted extracellular and intracellular DNA from anoxic sediments of ferruginous Lake Towuti, Indonesia...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28768738/altered-tactile-sensitivity-in-children-with-attention-deficit-hyperactive-disorder
#5
Nicolaas A J Puts, Ashley D Harris, Mark Mikkelsen, Mark Tommerdahl, Richard Ae Edden, Stewart H Mostofsky
ADHD is characterized by an inability to concentrate, heightened activity, and hypermotoric behavior, but sensory, e.g. tactile, problems are common. The literature on tactile impairments in ADHD is limited, with most work employing clinical observations or questionnaires. Here, we study tactile processing in children with ADHD, and hypothesize that children with ADHD show reduced performance in tasks closely linked to inhibition. Sixty seven children with ADHD and 62 typically developing children performed a battery of tasks grouped in domains: simple and choice reaction time; static and dynamic detection threshold (probing feed-forward inhibition); amplitude discrimination without adaptation, and with dual, and single-site adaptation (probing lateral inhibition and adaptation); sequential and simultaneous frequency discrimination (previously linked to GABA); and temporal order judgment with and without a synchronous carrier stimulus...
August 2, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28720807/fast-atom-transport-and-launching-in-a-nonrigid-trap
#6
A Tobalina, M Palmero, S Martínez-Garaot, J G Muga
We study the shuttling of an atom in a trap with controllable position and frequency. Using invariant-based inverse engineering, protocols in which the trap is simultaneously displaced and expanded are proposed to speed up transport between stationary trap locations as well as launching processes with narrow final-velocity distributions. Depending on the physical constraints imposed, either simultaneous or sequential approaches may be faster. We consider first a perfectly harmonic trap, and then extend the treatment to generic traps...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28702991/self-similar-hierarchical-wrinkles-as-a-potential-multifunctional-smart-window-with-simultaneously-tunable-transparency-structural-color-and-droplet-transport
#7
Gaojian Lin, Prashant Chandrasekaran, Cunjing Lv, Qiuting Zhang, Yichao Tang, Lin Han, Jie Yin
Smart window has immense potential for energy savings in architectural and vehicular applications, while most studies focus on the tunability of a single property of optical transmittance. Here we explore harnessing dynamically tunable hierarchical wrinkles for design of a potential multifunctional smart window with combined structural color and water droplet transport control. The self-similar hierarchical wrinkles with both nanoscale and microscale features are generated on a prestrained poly(dimethylsiloxane) elastomer through sequential strain release and multistep oxygen plasma treatment...
August 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28675036/asymmetric-conformational-transitions-in-aaa-biological-nanomachines-modulate-direction-dependent-substrate-protein-unfolding-mechanisms
#8
Abdolreza Javidialesaadi, George Stan
Powerful AAA+ biological nanomachines, such as ClpY, form hexameric ring structures, which selectively process abnormal proteins targeted for degradation by unfolding and threading them through a narrow central channel. The molecular details of this process are not yet fully understood. We perform Langevin dynamics simulations using a coarse-grained model of substrate proteins (SPs), Titin I27 and its V13P variant, threading through the ClpY pore. We probe the effect of ClpY surface heterogeneity and changes in pore width on SP orientation and the direction of applied force during SP unfolding...
July 27, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28673881/a-multimodal-encoding-model-applied-to-imaging-decision-related-neural-cascades-in-the-human-brain
#9
REVIEW
Jordan Muraskin, Truman R Brown, Jennifer M Walz, Tao Tu, Bryan Conroy, Robin I Goldman, Paul Sajda
Perception and cognition in the brain are naturally characterized as spatiotemporal processes. Decision-making, for example, depends on coordinated patterns of neural activity cascading across the brain, running in time from stimulus to response and in space from primary sensory regions to the frontal lobe. Measuring this cascade is key to developing an understanding of brain function. Here we report on a novel methodology that employs multi-modal imaging for inferring this cascade in humans at unprecedented spatiotemporal resolution...
June 30, 2017: NeuroImage
https://www.readbyqxmd.com/read/28649713/mechanistic-modeling-of-the-loss-of-protein-sieving-due-to-internal-and-external-fouling-of-microfilters
#10
Glen R Bolton, Alex J Apostolidis
Fed-batch and perfusion cell culture processes used to produce therapeutic proteins can utilize microfilters for product harvest. In this study, new explicit mathematical models of sieving loss due to internal membrane fouling, external membrane fouling, or a combination of the two were generated. The models accounted for membrane and cake structures and hindered solute transport. Internal membrane fouling was assumed to occur due to the accumulation of foulant on either membrane pore walls (pore-retention model) or membrane fibers (fiber-retention model)...
June 26, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28647847/the-processing-of-price-comparison-is-not-holistic-but-componential
#11
Pedro Macizo, Fernando Ojedo
In three experiments, we evaluate whether the processing of prices is holistic or componential. When participants receive two prices and they select the higher price, distance effects are found when the distances between the two prices are defined holistically but not when they are defined in terms of digits (Experiment 1). This result suggests that prices are processed holistically. However, we show that the holistic distance effect can be explained by the compatibility between the digits and the monetary category of prices (euro and cent)...
June 24, 2017: Psychological Research
https://www.readbyqxmd.com/read/28634757/a-uhplc-ms-ms-method-for-profiling-multifunctional-steroids-in-human-hair
#12
Zhen Dong, Caihong Wang, Jinlan Zhang, Zhe Wang
It is important to profile steroids in many physiological and pathological processes. Recently, hair has been used for the long-term measurement of endogenous steroid hormones. Analyzing hair has advantages of being noninvasive and time sequential compared with other bio-specimens. Liquid chromatography-mass spectrometry (LC-MS) techniques have been widely used over the past decades; however, it is challenging to profile estrogens in hair by LC-MS, and more comprehensive steroid profiling is required. In this paper, an ultra high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed to simultaneously profile 28 multifunctional steroids, including corticosteroids (n = 6), estrogens (n = 13), androgens (n = 5) and progestogens (n = 4), in human scalp hair in a single run...
June 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28633622/search-for-capacity-limited-and-super-capacity-search
#13
Suk Won Han
The present study investigated capacity limitations of visual search. In a series of experiments, participants searched for a singleton target among homogenous distractors, a conjunction target defined by combination of two features, or a feature target among heterogeneous distractors. Using the simultaneous-sequential paradigm, I found that singleton search proceeded in a capacity-unlimited manner. By contrast, the performance of the conjunction search was found to depend on a capacity-limited process. For feature searches, the performance of searching for a specific color was not affected by how the stimuli were presented, while the orientation search performance was enhanced as the number of distractors simultaneously presented with the target increased...
May 2017: Experimental Psychology
https://www.readbyqxmd.com/read/28629040/3-aminopropyltrimethoxysilane-mediated-solvent-induced-synthesis-of-gold-nanoparticles-for-biomedical-applications
#14
Prem C Pandey, Gunjan Pandey, Alain Walcarius
The effect of acetone on 3-aminopropyltrimethoxysilane (3-APTMS) mediated synthesis of gold nanoparticles (AuNPs) in polar protic, polar aprotic and non polar solvents specifically water, acetone and chloroform has been studied. The findings revealed that acetone promotes the formation of siloxane polymer in chloroform and acetone solvents, but not in water, while AuNPs are formed in all cases. The bifunctional nature of 3-APTMS [NH2(CH2)3Si(OMe)3] controls the formation of siloxane polymer through hydrolysis and condensation of trimethoxysilyl group whereas the amine moieties are likely to form imine linkage, which are involved in the synthesis of gold nanoparticles...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28624152/simultaneous-determination-of-14-disinfection-by-products-in-meat-products-using-microwave-assisted-extraction-and-static-headspace-coupled-to-gas-chromatography-mass-spectrometry
#15
Maria Jose Cardador, Mercedes Gallego
This paper described the first analytical method to simultaneously determine 14 disinfection by-products (DBPs) in meat products using microwave-assisted extraction (MAE) and static headspace (SHS) followed by gas chromatography-mass spectrometry (GC-MS). The DBPs included were 4 trihalomethanes, 7 haloacetic acids, 2 haloacetonitriles and trichloronitromethane, which are commonly formed as a consequence of the disinfection process of water. The combination of the MAE and SHS techniques allows meat samples to be analysed in two sequential steps into the same HS vial in spite of the sample's complexity...
August 4, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28614750/2d-cos-of-in-situ-%C3%AE-raman-and-in-situ-ir-spectra-for-structure-evolution-characterisation-of-nep-deposited-cobalt-oxide-catalyst-during-n-nonane-combustion
#16
Damian K Chlebda, Przemysław J Jodłowski, Roman J Jędrzejczyk, Joanna Łojewska
New catalytic systems are still in development to meet the challenge of regulations concerning the emission of volatile organic compounds (VOCs). This is because such compounds have a significant impact on air quality and some of them are toxic to the environment and human beings. The catalytic combustion process of VOCs over non-noble metal catalysts is of great interest to researchers. The high conversion parameters and cost effective preparation makes them a valuable alternative to monoliths and noble metal catalysts...
June 6, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28607772/dark-signals-in-the-choroidal-vasculature-on-optical-coherence-tomography-angiography-an-artefact-or-not
#17
REVIEW
Rui Hua, Hailin Wang
Optical coherence tomography angiography (OCTA) based on mathematical processing of sequentially acquired structural OCT images has been applied widely in both retinal and choroidal research and may have advantages over traditional angiography. Images obtained by OCTA are rendered under the assumption that the only moving entity in the retina is blood flow. Optical phenomena and image processing algorithms may create imaging artefacts. Therefore, OCTA images require careful interpretation. This review discusses the dark signals seen in the choroidal vasculature on OCTA using multiple factor analysis...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28587703/make-it-two-a-case-report-of-dual-sequential-external-defibrillation
#18
Colin R Bell, Adam Szulewski, Steven C Brooks
Dual sequential external defibrillation (DSED) is the process of near simultaneous discharge of two defibrillators with differing pad placement to terminate refractory arrhythmias. Previously used in the electrophysiology suite, this technique has recently been used in the emergency department and prehospital setting for out-of-hospital cardiac arrest (OHCA). We present a case of successful DSED in the emergency department with neurologically intact survival to hospital discharge after refractory ventricular fibrillation (RVF) and review the putative mechanisms of action of this technique...
June 7, 2017: CJEM
https://www.readbyqxmd.com/read/28559878/attentional-capture-to-a-singleton-distractor-degrades-visual-marking-in-visual-search
#19
Kenji Yamauchi, Takayuki Osugi, Ikuya Murakami
Visual search is easier after observing some distractors in advance; it is as if the previewed distractors were excluded from the search. This effect is referred to as the preview benefit, and a memory template that visually marks the old locations of the distractors is thought to help in prioritizing the locations of newly presented items. One remaining question is whether the presence of a conspicuous item during the sequential shift of attention within the new items reduces this preview benefit. To address this issue, we combined the above preview search and a conventional visual search paradigm using a singleton distractor and examined whether the search performance was affected by the presence of the singleton...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28556559/synbiotic-fermentation-for-the-co-production-of-lactic-and-lactobionic-acids-from-residual-dairy-whey
#20
Cristina García, Manuel Rendueles, Mario Díaz
Besides its properties as an antioxidant, stabilizer or acidifier, lactobionic acid has emerged as a potential prebiotic compound, raising the possibility of being included together with the probiotic microorganism Lactobacillus casei in novel functional fermented foods with synbiotic characteristics. Their manufacturing strategy could benefit from the recently implemented microbial synthesis of lactobionic acid by the strong producer Pseudomonas taetrolens, employing residual dairy whey as raw material. The phenomenon of amensalism established between Pseudomonas and Lactobacillus makes simultaneous fermentation unfeasible...
May 27, 2017: Biotechnology Progress
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