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https://www.readbyqxmd.com/read/28525780/age-of-despair-or-age-of-hope-palestinian-women-s-perspectives-on-midlife-health
#1
Doaa Hammoudeh, Ernestina Coast, David Lewis, Yoke van der Meulen, Tiziana Leone, Rita Giacaman
There is limited evidence about women's experiences of the midlife, beyond a narrow - frequently biomedical - focus on the menopause. The broader (physical, social, cultural, political) dimensions of women's midlife health are poorly understood, particularly in low and middle-income countries. Our study seeks to understand how women in the West Bank (occupied Palestinian territories) conceptualise, experience and manage their health in the midlife. We generated qualitative evidence using in-depth life history interviews in 2015 with women (n = 35) living in the West Bank, analysed thematically...
May 11, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28508050/butterfly-gyroid-nanostructures-as-a-time-frozen-glimpse-of-intracellular-membrane-development
#2
Bodo D Wilts, Benjamin Apeleo Zubiri, Michael A Klatt, Benjamin Butz, Michael G Fischer, Stephen T Kelly, Erdmann Spiecker, Ullrich Steiner, Gerd E Schröder-Turk
The formation of the biophotonic gyroid material in butterfly wing scales is an exceptional feat of evolutionary engineering of functional nanostructures. It is hypothesized that this nanostructure forms by chitin polymerization inside a convoluted membrane of corresponding shape in the endoplasmic reticulum. However, this dynamic formation process, including whether membrane folding and chitin expression are simultaneous or sequential processes, cannot yet be elucidated by in vivo imaging. We report an unusual hierarchical ultrastructure in the butterfly Thecla opisena that, as a solid material, allows high-resolution three-dimensional microscopy...
April 2017: Science Advances
https://www.readbyqxmd.com/read/28507825/spatiotemporal-strategies-for-joint-segmentation-and-motion-tracking-from-cardiac-image-sequences
#3
Huafeng Liu, Ting Wang, Lei Xu, Pengcheng Shi
Although accurate and robust estimations of the deforming cardiac geometry and kinematics from cine tomographic medical image sequences remain a technical challenge, they have significant clinical value. Traditionally, boundary or volumetric segmentation and motion estimation problems are considered as two sequential steps, even though the order of these processes can be different. In this paper, we present an integrated, spatiotemporal strategy for the simultaneous joint recovery of these two ill-posed problems...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/28504684/fully-automated-5-plex-fluorescent-immunohistochemistry-with-tyramide-signal-amplification-and-same-species-antibodies
#4
Wenjun Zhang, Antony Hubbard, Tobin Jones, Adriana Racolta, Srabani Bhaumik, Nick Cummins, Liping Zhang, Karl Garsha, Frank Ventura, Mark R Lefever, Zhenqiang Lu, John K Hurley, William A Day, Lidija Pestic-Dragovich, Larry E Morrison, Lei Tang
The ability to simultaneously visualize the presence, abundance, location and functional state of many targets in cells and tissues has been described as a true next-generation approach in immunohistochemistry (IHC). A typical requirement for multiplex IHC (mIHC) is the use of different animal species for each primary (1°Ab) and secondary (2°Ab) antibody pair. Although 1°Abs from different species have been used with differently labeled species-specific 2°Abs, quite often the appropriate combination of antibodies is not available...
May 15, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28504643/exploiting-neurovascular-coupling-a-bayesian-sequential-monte-carlo-approach-applied-to-simulated-eeg-fnirs-data
#5
Pierpaolo Croce, Filippo Zappasodi, Arcangelo Merla, Antonio Chiarelli
OBJECTIVE: Electrical and hemodynamic brain activity are linked through the neurovascular coupling process and they can be simultaneously measured through integration of Electroencephalography (EEG) and functional Near-Infrared Spectroscopy (fNIRS). Thanks to the lack of electro-optical interference, the two procedures can be easily combined and, whereas EEG provides electrophysiological information, fNIRS can provide measurements of two hemodynamic variables, such as oxygenated and deoxygenated hemoglobin...
May 15, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28487406/set1a-compass-and-shadow-enhancers-in-the-regulation-of-homeotic-gene-expression
#6
Kaixiang Cao, Clayton K Collings, Stacy A Marshall, Marc A Morgan, Emily J Rendleman, Lu Wang, Christie C Sze, Tianjiao Sun, Elizabeth T Bartom, Ali Shilatifard
The homeotic (Hox) genes are highly conserved in metazoans, where they are required for various processes in development, and misregulation of their expression is associated with human cancer. In the developing embryo, Hox genes are activated sequentially in time and space according to their genomic position within Hox gene clusters. Accumulating evidence implicates both enhancer elements and noncoding RNAs in controlling this spatiotemporal expression of Hox genes, but disentangling their relative contributions is challenging...
May 9, 2017: Genes & Development
https://www.readbyqxmd.com/read/28482576/folate-decorated-pegylated-triblock-copolymer-as-a-ph-reduction-dual-responsive-nanovehicle-for-targeted-intracellular-co-delivery-of-doxorubicin-and-bcl-2-sirna
#7
Aili Suo, Junmin Qian, Minghui Xu, Weijun Xu, Yaping Zhang, Yu Yao
Co-delivery of chemotherapeutic drug and small interfering RNA (siRNA) within a single nanovehicle has emerged as a promising combination therapy approach to treating cancers because of their synergistic effect. Nanocarrier delivery systems with low cytotoxicity and high efficiency are needed for such a purpose. In this study, a novel folate-conjugated PEGylated cationic triblock copolymer, poly(acrylhydrazine)-block-poly(3-dimethylaminopropyl methacrylamide)-block-poly(acrylhydrazine) (PAH-b-PDMAPMA-b-PAH), was synthesized and evaluated as a stimuli-sensitive vehicle for the targeted co-delivery of doxorubicin (DOX) and Bcl-2 siRNA into breast cancer MCF-7 cells...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28460957/one-step-global-parameter-estimation-of-kinetic-inactivation-parameters-for-bacillus-sporothermodurans-spores-under-static-and-dynamic-thermal-processes
#8
F Cattani, K D Dolan, S D Oliveira, D K Mishra, C A S Ferreira, P M Periago, A Aznar, P S Fernandez, V P Valdramidis
Bacillus sporothermodurans produces highly heat-resistant endospores, that can survive under ultra-high temperature. High heat-resistant sporeforming bacteria are one of the main causes for spoilage and safety of low-acid foods. They can be used as indicators or surrogates to establish the minimum requirements for heat processes, but it is necessary to understand their thermal inactivation kinetics. The aim of the present work was to study the inactivation kinetics under both static and dynamic conditions in a vegetable soup...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28458748/resolving-conflicts-between-syntax-and-plausibility-in-sentence-comprehension
#9
Glenda Andrews, Jessica E Ogden, Graeme S Halford
Comprehension of plausible and implausible object- and subject-relative clause sentences with and without prepositional phrases was examined. Undergraduates read each sentence then evaluated a statement as consistent or inconsistent with the sentence. Higher acceptance of consistent than inconsistent statements indicated reliance on syntactic analysis. Higher acceptance of plausible than implausible statements reflected reliance on semantic plausibility. There was greater reliance on semantic plausibility and lesser reliance on syntactic analysis for more complex object-relatives and sentences with prepositional phrases than for less complex subject-relatives and sentences without prepositional phrases...
2017: Advances in Cognitive Psychology
https://www.readbyqxmd.com/read/28457750/single-cell-rna-seq-analysis-maps-development-of-human-germline-cells-and-gonadal-niche-interactions
#10
Li Li, Ji Dong, Liying Yan, Jun Yong, Xixi Liu, Yuqiong Hu, Xiaoying Fan, Xinglong Wu, Hongshan Guo, Xiaoye Wang, Xiaohui Zhu, Rong Li, Jie Yan, Yuan Wei, Yangyu Zhao, Wei Wang, Yixin Ren, Peng Yuan, Zhiqiang Yan, Boqiang Hu, Fan Guo, Lu Wen, Fuchou Tang, Jie Qiao
Human fetal germ cells (FGCs) are precursors to sperm and eggs and are crucial for maintenance of the species. However, the developmental trajectories and heterogeneity of human FGCs remain largely unknown. Here we performed single-cell RNA-seq analysis of over 2,000 FGCs and their gonadal niche cells in female and male human embryos spanning several developmental stages. We found that female FGCs undergo four distinct sequential phases characterized by mitosis, retinoic acid signaling, meiotic prophase, and oogenesis...
April 13, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28439250/differential-impact-of-visuospatial-working-memory-on-rule-based-and-information-integration-category-learning
#11
Qiang Xing, Hailong Sun
Previous studies have indicated that the category learning system is a mechanism with multiple processing systems, and that working memory has different effects on category learning. But how does visuospatial working memory affect perceptual category learning? As there is no definite answer to this question, we conducted three experiments. In Experiment 1, the dual-task paradigm with sequential presentation was adopted to investigate the influence of visuospatial working memory on rule-based and information-integration category learning...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28434787/integrated-ecotechnology-approach-towards-treatment-of-complex-wastewater-with-simultaneous-bioenergy-production
#12
Manupati Hemalatha, J Shanthi Sravan, Dileep Kumar Yeruva, S Venkata Mohan
Sequential integration of three stage diverse biological processes was studied by exploiting the individual process advantage towards enhanced treatment of complex chemical based wastewater. A successful attempt to integrate sequence batch reactor (SBR) with bioelectrochemical treatment (BET) and finally with microalgae treatment was studied. The sequential integration has showed individual substrate degradation (COD) of 55% in SBR, 49% in BET and 56% in microalgae, accounting for a consolidated treatment efficiency of 90%...
March 22, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28413698/simultaneous-bilateral-cochlear-implants-developmental-advances-do-not-yet-achieve-normal-cortical-processing
#13
Vijayalakshmi Easwar, Hiroshi Yamazaki, Michael Deighton, Blake Papsin, Karen Gordon
BACKGROUND: Simultaneous bilateral cochlear implantation promotes symmetric development of bilateral auditory pathways but binaural hearing remains abnormal. To evaluate whether bilateral cortical processing remains impaired in such children, cortical activity to unilateral and bilateral stimuli was assessed in a unique cohort of 16 children who received bilateral cochlear implants (CIs) simultaneously at 1.97 ± 0.86 years of age and had ~4 years of CI experience, providing the first opportunity to assess electrically driven cortical development in the absence of reorganized asymmetries from sequential implantation...
April 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28409657/estimates-of-functional-cerebral-hemispheric-differences-in-monolingual-and-bilingual-people-who-stutter-dual-task-paradigm
#14
Myriam Kornisch, Michael P Robb, Richard D Jones
The inter-relationship of stuttering and bilingualism to functional cerebral hemispheric processing was examined on a dual-task paradigm. Eighty native German (L1) speakers, half of whom were sequential bilinguals (L2 = English), were recruited. The participants (mean age = 38.9 years) were organised into four different groups according to speech status and language ability: 20 bilinguals who stutter (BWS), 20 monolinguals who stutter (MWS), 20 bilinguals who do not stutter (BWNS), and 20 monolinguals who do not stutter (MWNS)...
2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/28401699/sling-scoop-squirter-anatomical-features-facilitating-prey-transport-processing-and-swallowing-in-rorqual-whales-mammalia-balaenopteridae
#15
Alexander J Werth, Haruka Ito
Much is known about lunge feeding in balaenopterid whales, but many key aspects of structure, function, and behavior have not yet been explained in detail, especially with regard to concentrating, positioning, and swallowing large aggregations of prey. We describe a novel system of three integrated structural components, all of which are involved in sequential feeding activities (intraoral transport, filtration, and swallowing of prey) that follow lunge-feeding engulfment of prey-laden water in rorquals: 1) a hammock-like muscular sling comprising extrinsic lingual musculature along the midline of the ventral pouch; 2) the flattened scoop-like arrangement of caudal-most baleen plates converging in the oropharynx adjacent to the esophageal opening; and 3) a flow-diverting flange at the posterior dorsum of the lip, by a flow channel at the angle of the mouth...
April 12, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28400723/electrophysiological-correlates-of-familiarity-and-recollection-in-associative-recognition-contributions-of-perceptual-and-conceptual-processing-to-unitization
#16
Bingcan Li, Xinrui Mao, Yujuan Wang, Chunyan Guo
It is generally accepted that associative recognition memory is supported by recollection. In addition, recent research indicates that familiarity can support associative memory, especially when two items are unitized into a single item. Both perceptual and conceptual manipulations can be used to unitize items, but few studies have compared these two methods of unitization directly. In the present study, we investigated the effects of familiarity and recollection on successful retrieval of items that were unitized perceptually or conceptually...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28400170/enhanced-simultaneous-saccharification-and-fermentation-of-pretreated-beech-wood-by-in-situ-treatment-with-the-white-rot-fungus-irpex-lacteus-in-a-membrane-aerated-biofilm-reactor
#17
Simone Brethauer, Shahab Robert Lawrence, Studer Michael Hans-Peter
The aim of the present study was to investigate the combination of steam pretreatment and biological treatment with lignin degrading fungal strains in order to enable efficient bioprocessing of beech wood to ethanol. In a sequential process of steam and fungal pretreatment followed by enzymatic hydrolysis, Irpex lacteus almost doubled the glucose yield for mildly pretreated beech wood, but could not improve yields for more severely pretreated substrates. However, when simultaneous saccharification and fermentation is combined with in situ I...
March 18, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28385113/hypoxia-for-mesenchymal-stem-cell-expansion-and-differentiation-the-best-way-for-enhancing-tgf%C3%A3-induced-chondrogenesis-and-preventing-calcifications-in-alginate-beads
#18
Christel Henrionnet, Gai Liang, Emilie Roeder, Manuel Dossot, Hui Wang, Jacques Magdalou, Pierre Gillet, Astrid Pinzano
We examined the respective influence of a sequential or a continuous hypoxia during expansion and transforming growth factor beta 1-driven chondrogenic differentiation of human bone marrow mesenchymal stem cells (MSCs). The differentiation was performed within alginate beads, a classical tool for the implantation of MSCs within the joint. The standard normoxic 2D (expansion) and 3D (differentiation) MSCs cultures served as reference. To determine the quality of chondrogenesis, we analyzed typical markers such as type II and X collagens, SOX9, COMP, versican, and aggrecan mRNAs using polymerase chain reaction and we assessed the production of type II collagen and hypoxia-inducible factor (HIF)-1α by histological stainings...
May 5, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28382639/adaptive-anchoring-model-how-static-and-dynamic-presentations-of-time-series-influence-judgments-and-predictions
#19
Petko Kusev, Paul van Schaik, Krasimira Tsaneva-Atanasova, Asgeir Juliusson, Nick Chater
When attempting to predict future events, people commonly rely on historical data. One psychological characteristic of judgmental forecasting of time series, established by research, is that when people make forecasts from series, they tend to underestimate future values for upward trends and overestimate them for downward ones, so-called trend-damping (modeled by anchoring on, and insufficient adjustment from, the average of recent time series values). Events in a time series can be experienced sequentially (dynamic mode), or they can also be retrospectively viewed simultaneously (static mode), not experienced individually in real time...
April 6, 2017: Cognitive Science
https://www.readbyqxmd.com/read/28362897/distinct-perceptual-rhythms-for-feature-and-conjunction-searches
#20
Laura Dugué, Alice M Xue, Marisa Carrasco
Feature and conjunction searches are widely used to study attentional deployment. However, the spatiotemporal behavior of attention integration in these tasks remains under debate. Are multiple search stimuli processed in parallel or sequentially? Does sampling of visual information and attentional deployment differ between these two types of search? If so, how? We used an innovative methodology to estimate the distribution of attention on a single-trial basis for feature and conjunction searches. Observers performed feature- and conjunction-search tasks...
March 1, 2017: Journal of Vision
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