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https://www.readbyqxmd.com/read/28637243/nanopore-sequencing-data-analysis-state-of-the-art-applications-and-challenges
#1
Alberto Magi, Roberto Semeraro, Alessandra Mingrino, Betti Giusti, Romina D'Aurizio
The nanopore sequencing process is based on the transit of a DNA molecule through a nanoscopic pore, and since the 90s is considered as one of the most promising approaches to detect polymeric molecules. In 2014, Oxford Nanopore Technologies (ONT) launched a beta-testing program that supplied the scientific community with the first prototype of a nanopore sequencer: the MinION. Thanks to this program, several research groups had the opportunity to evaluate the performance of this novel instrument and develop novel computational approaches for analyzing this new generation of data...
June 16, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28636746/evaluation-of-the-parent-report-inventory-of-callous-unemotional-traits-in-a-sample-of-children-recruited-from-intimate-partner-violence-services-a-multidimensional-rasch-analysis
#2
Shelby Elaine McDonald, Lin Ma, Kathy E Green, Stephanie A Hitti, Anna M Cody, Courtney Donovan, James Herbert Williams, Frank R Ascione
OBJECTIVE: Our study applied multidimensional item response theory (MIRT) to compare structural models of the parent-report version of the Inventory of Callous and Unemotional Traits (ICU; English and North American Spanish translations). METHOD: A total of 291 maternal caregivers were recruited from community-based domestic violence services and reported on their children (77.9% ethnic minority; 47% female), who ranged in age from 7 to 12 years (mean = 9.07, standard deviation = 1...
June 21, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28635539/an-old-challenge-with-new-promises-a-systematic-review-on-comprehensive-geriatric-assessment-in-long-term-care-facilities
#3
Francesco Panza, Vincenzo Solfrizzi, Madia Lozupone, Maria Rosaria Barulli, Francesca D'Urso, Roberta Stallone, Vittorio Dibello, Alessia Noia, Cristina Di Dio, Antonio Daniele, Antonello Bellomo, Davide Seripa, Antonio Greco, Giancarlo Logroscino
Comprehensive geriatric assessment (CGA) is a multidimensional and multidisciplinary diagnostic process focused on determining the clinical profile, pathological risk, residual skills, short- and long-term prognosis, and the personalized therapeutic and care plan of the functionally compromised and frail older subjects. Previous evidence suggested that the effectiveness of CGA programs may be influenced by the settings where the CGA is performed [i.e., hospital, post-hospital discharge/ long-term care facilities (LTCF), or community/home] as well as the specific clinical conditions of older frail individuals...
June 21, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28634758/a-general-double-library-selex-strategy-for-aptamer-selection-using-unmodified-nonimmobilized-targets
#4
Kyung Hyun Lee, Huaqiang Zeng
Aptamer discovery for unmodified nonimmobilized targets has been constantly presenting itself as a significant challenge to the research community. We demonstrate here a novel double library (DL) SELEX strategy and its usefulness and generality toward discovering both ssDNA- and RNA-based aptamers with nanomolar binding affinities toward unmodified targets of both small (e.g., doxycycline) and large (e.g., VEGF165) sizes. The same selection strategy further allows for concurrent selection of an aptamer pair, recognizing discrete epitopes on the same protein, from the same selection cycles for the sandwich aptamer pair-based biosensor development (e...
June 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28633629/prevalence-of-and-risk-factors-for-severe-cognitive-and-sleep-symptoms-in-me-cfs-and-ms
#5
Vageesh Jain, Amit Arunkumar, Caroline Kingdon, Eliana Lacerda, Luis Nacul
BACKGROUND: There are considerable phenotypic and neuroimmune overlaps between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and multiple sclerosis (MS). While the precise aetiologies of both MS and ME/CFS are unclear, evidence suggests that deterioration in cognitive function is widely prevalent in patients with either condition. Little is known about differing risk factors or exposures, which may lead to severe cognitive or sleep symptoms. This study aims to gauge the extent of cognitive and sleep symptoms in ME/CFS and MS patients participating in the UK ME/CFS Biobank and identify the characteristics of those experiencing severe symptoms...
June 20, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28633566/microsphere-based-scaffolds-in-regenerative-engineering
#6
Vineet Gupta, Yusuf Khan, Cory J Berkland, Cato T Laurencin, Michael S Detamore
Microspheres have long been used in drug delivery applications because of their controlled release capabilities. They have increasingly served as the fundamental building block for fabricating scaffolds for regenerative engineering because of their ability to provide a porous network, offer high-resolution control over spatial organization, and deliver growth factors/drugs and/or nanophase materials. Because they provide physicochemical gradients via spatiotemporal release of bioactive factors and nanophase ceramics, microspheres are a desirable tool for engineering complex tissues and biological interfaces...
June 21, 2017: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/28633565/febio-history-and-advances
#7
Steve A Maas, Gerard A Ateshian, Jeffrey A Weiss
The principal goal of the FEBio project is to provide an advanced finite element tool for the biomechanics and biophysics communities that allows researchers to model mechanics, transport, and electrokinetic phenomena for biological systems accurately and efficiently. In addition, because FEBio is geared toward the research community, the code is designed such that new features can be added easily, thus making it an ideal tool for testing novel computational methods. Finally, because the success of a code is determined by its user base, integral goals of the FEBio project have been to offer support and outreach to our community; to provide mechanisms for dissemination of results, models, and data; and to encourage interaction between users...
June 21, 2017: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/28633542/deciphering-participation-an-interpretive-synthesis-of-its-meaning-and-application-in-rehabilitation
#8
Alison M Cogan, Mike Carlson
PURPOSE: Participation is widely recognized as an important outcome for rehabilitation. However, it lacks a universally accepted definition. The purpose of this review is to synthesize the literature about participation in rehabilitation in order to clarify the term and increase its usefulness for rehabilitation providers and researchers. METHODS: We undertook an interpretive synthesis of the literature, drawing from a broad and varied selection of the vast number of publications on the subject of participation...
June 21, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28633384/correlates-of-dyspnoea-and-its-association-with-adverse-outcomes-in-a-cohort-of-adults-aged-80-and-over
#9
Eralda Hegendörfer, Bert Vaes, Catharina Matheï, Gijs Van Pottelbergh, Jean-Marie Degryse
Background: adults aged 80 and over, a fast growing age-group, with increased co-morbidity and frailty have not been the focus of previous research on dyspnoea. We investigate the correlates of dyspnoea and its association with adverse outcomes in a cohort of adults aged 80 and over. Methods: about 565 community-dwelling adults aged 80 and over of the BELFRAIL prospective cohort had assessment of Medical Research Council dyspnoea scale (MRC), forced expiratory volume in 1 s (FEV1), N-terminal pro-brain natriuretic peptide (NT-proBNP), physical performance tests, grip strength, 15 items geriatric depression scale, activities of daily living (ADL), body mass index (BMI) and demographics data...
June 14, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28632983/a-descriptive-study-of-a-community-based-home-visiting-program-with-preschool-children-prenatally-exposed-to-alcohol
#10
Ana Hanlon-Dearman, Sayma Malik, Julia Wellwood, Karen Johnston, Holly Gammon, Kathy N Andrew, Breann Maxwell, Sally Longstaffe
BACKGROUND: Research suggests that prenatal alcohol exposure (PAE) and Fetal Alcohol Spectrum Disorder (FASD) increases the risk of insecure caregiver-child attachment and related negative child emotional-behavioural outcomes. Research also shows positive effects of attachment-focused interventions in preventing disrupted caregiver-child attachment relationships; however, such interventions have not been specifically adapted for children with FASD. OBJECTIVES: This paper describes the implementation, challenges, and results of a community home-based attachment intervention, Circle of Security® (COS), with preschool children affected by PAE/FASD in Manitoba, Canada...
June 14, 2017: Journal of Population Therapeutics and Clinical Pharmacology
https://www.readbyqxmd.com/read/28632745/evaluating-patterns-and-drivers-of-spatial-change-in-the-recreational-guided-fishing-sector-in-alaska
#11
Maggie N Chan, Anne H Beaudreau, Philip A Loring
Understanding the impacts of recreational fishing on habitats and species, as well as the social and ecological importance of place to anglers, requires information on the spatial distribution of fishing activities. This study documented long-term changes in core fishing areas of a major recreational fishery in Alaska and identified biological, regulatory, social, and economic drivers of spatial fishing patterns by charter operators. Using participatory mapping and in-person interviews, we characterized the spatial footprint of 46 charter operators in the communities of Sitka and Homer since the 1990s...
2017: PloS One
https://www.readbyqxmd.com/read/28632445/critique-and-contribute-a-practice-based-framework-for-improving-critical-data-studies-and-data-science
#12
Gina Neff, Anissa Tanweer, Brittany Fiore-Gartland, Laura Osburn
What would data science look like if its key critics were engaged to help improve it, and how might critiques of data science improve with an approach that considers the day-to-day practices of data science? This article argues for scholars to bridge the conversations that seek to critique data science and those that seek to advance data science practice to identify and create the social and organizational arrangements necessary for a more ethical data science. We summarize four critiques that are commonly made in critical data studies: data are inherently interpretive, data are inextricable from context, data are mediated through the sociomaterial arrangements that produce them, and data serve as a medium for the negotiation and communication of values...
June 2017: Big Data
https://www.readbyqxmd.com/read/28632162/beyond-food-access-the-impact-of-parent-home-and-neighborhood-level-factors-on-children-s-diets
#13
Lauren Futrell Dunaway, Thomas Carton, Ping Ma, Adrienne R Mundorf, Kelsey Keel, Katherine P Theall
Despite the growth in empirical research on neighborhood environmental characteristics and their influence on children's diets, physical activity, and obesity, much remains to be learned, as few have examined the relationship between neighborhood food availability on dietary behavior in children, specifically. This analysis utilized data from a community-based, cross-sectional sample of children (n = 199) that was collected in New Orleans, Louisiana, in 2010. This dataset was linked to food environment data to assess the impact of neighborhood food access as well as household and parent factors on children's diets...
June 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28631537/sustainability-in-care-through-an-ethical-practice-model
#14
Linda Nyholm, Susanne Salmela, Lisbet Nyström, Camilla Koskinen
BACKGROUND: While sustainability is a key concept in many different domains today, it has not yet been sufficiently emphasized in the healthcare sector. Earlier research shows that ethical values and evidence-based care models create sustainability in care practice. OBJECTIVE: The aim of this study was to gain further understanding of the ethical values central to the realization of sustainability in care and to create an ethical practice model whereby these basic values can be made perceptible and active in care practice...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28631259/preventive-healthcare-and-health-promotion-in-local-governments-based-on-the-example-of-health-policy-programmes-concerned-with-cardiovascular-diseases-implemented-in-poland-in-2009-2014
#15
Anna Augustynowicz, Aleksandra Czerw, Mariola Kowalska, Krzysztof Bobiński, Adam Fronczak
BACKGROUND: Cardiovascular diseases (CVD) are the cause of over 4.3 million deaths in the World Health Organisation European Region and around 1.9 million deaths in the European Union member states alone. They are also the number-one cause of death in Poland. In 2010 CVDs accounted for 46% of all deaths, and in 2013 - 45.8%. AIM: The aim of the study was to evaluate the performance of the tasks of local government units in the area of preventive healthcare and health promotion on the basis of health policy programmes concerning CVD...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28630549/why-is-a-good-abortion-law-not-enough-the-case-of-estonia
#16
Liiri Oja
There are various ways to critically discuss abortion. Constructing or finding the most suitable analytical framework-whether rooted in legal formalism, socio-legal considerations, or comparativism-always depends on the country of subject and whether the analysis is for litigation, advocacy, or more theoretical purposes. This paper offers a model for analyzing abortion in Estonia in order to connect it as a thought-provoking case study to the ongoing transnational abortion discussions. I set out by describing the Estonian Abortion Act as a "good abortion law": a regulation that guarantees in practice women's legal access to safe abortion...
June 2017: Health and Human Rights
https://www.readbyqxmd.com/read/28630291/global-sustainable-development-priorities-500-y-after-luther-sola-schola-et-sanitate
#17
Wolfgang Lutz
Martin Luther succinctly summarized his theology in sola statements, such as sola scriptura, viewing the Bible (scriptura) as the only valid source of information about God rather than what he viewed as the extraneous, corrupting church doctrine of the time. As a secular side effect of this focus on individual reading skills, the Protestant territories were the first to acquire high literacy rates, which subsequently fostered health, economic growth, and good governance. Here I argue that a similar priority focus on empowerment of all segments of all populations through education and health (sola schola et sanitate) is needed today for sustainable development...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28630034/fall-prevention-self-assessments-via-mobile-3d-visualization-technologies-community-dwelling-older-adults-perceptions-of-opportunities-and-challenges
#18
Julian Hamm, Arthur Money, Anita Atwal
BACKGROUND: In the field of occupational therapy, the assistive equipment provision process (AEPP) is a prominent preventive strategy used to promote independent living and to identify and alleviate fall risk factors via the provision of assistive equipment within the home environment. Current practice involves the use of paper-based forms that include 2D measurement guidance diagrams that aim to communicate the precise points and dimensions that must be measured in order to make AEPP assessments...
June 19, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/28629382/community-first-responders-and-responder-schemes-in-the-united-kingdom-systematic-scoping-review
#19
Viet-Hai Phung, Ian Trueman, Fiona Togher, Roderick Orner, A Niroshan Siriwardena
BACKGROUND: Community First Responder (CFR) schemes support lay people to respond to medical emergencies, working closely with ambulance services. They operate widely in the UK. There has been no previous review of UK literature on these schemes. This is the first systematic scoping review of UK literature on CFR schemes, which identifies the reasons for becoming a CFR, requirements for training and feedback and confusion between the CFR role and that of ambulance service staff. This study also reveals gaps in the evidence base for CFR schemes...
June 19, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28629349/relationships-between-dental-personnel-and-non-dental-primary-health-care-providers-in-rural-and-remote-queensland-australia-dental-perspectives
#20
Jackie Stuart, Ha Hoang, Len Crocombe, Tony Barnett
BACKGROUND: Collaboration between dental practitioners and non-dental primary care providers has the potential to improve oral health care for people in rural and remote communities, where access to oral health services is limited. However, there is limited research on collaboration between these professional disciplines. The purpose of this paper was to explore the relationships between dental practitioners and non-dental primary care providers from rural and remote areas of Queensland and to identify strategies that could improve collaboration between these disciplines from the perspective of dental participants...
June 19, 2017: BMC Oral Health
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