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https://www.readbyqxmd.com/read/29615274/conventional-monitoring-is-not-sufficient-to-assess-respiratory-effort-during-assisted-ventilation
#1
F Ruiz Ferrón, J M Serrano Simón
OBJECTIVE: Study the relationship and concordance between calculated respiratory effort using the signals of the ventilator (Pmus) and that measured in esophageal pressure (Pes) on mechanical ventilation with different levels of respiratory assistance. DESIGN: Prospective cohort study. AMBIT: Intensive Care Unit of 2 universitary hospitals. Patients Patients on weaning time. PROCEDURE: Airway, esophageal and respiratory flow were recorded on CPAP, assist volume control (ACV) and pressure support (PS), with complete (ACV1,PS1) and partial assistance (ACV5,PS5)...
March 31, 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/29602045/chemoenzymatic-synthesis-of-new-derivatives-of-glycyrrhetinic-acid-with-antiviral-activity-molecular-docking-study
#2
M Antonela Zígolo, Maximiliano Salinas, Laura Alché, Alicia Baldessari, Guadalupe García Liñares
We present an efficient approach to the synthesis of a series of glycyrrhetinic acid derivatives. Six derivatives, five of them new compounds, were obtained through chemoenzymatic reactions in very good to excellent yield. In order to find the optimal reaction conditions, the influence of various parameters such as enzyme source, nucleophile:substrate ratio, enzyme:substrate ratio, solvent and temperature was studied. The excellent results obtained by lipase catalysis made the procedure very efficient considering their advantages such as mild reaction conditions and low environmental impact...
March 19, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29588235/a-comparison-of-computed-tomography-based-scales-with-and-without-consideration-of-the-presence-or-absence-of-intraventricular-hemorrhage-in-patients-with-aneurysmal-subarachnoid-hemorrhage
#3
Tetsuji Inagawa, Masaaki Shibukawa, Toshikazu Hidaka
OBJECTIVE: There has been controversy as to whether intraventricular hemorrhage (IVH) after aneurysmal subarachnoid hemorrhage (SAH) contributes to angiographic cerebral vasospasm (aCV) and delayed cerebral ischemia (DCI). CT-based SAH scales that did and did not consider IVH were compared in terms of ability to predict aCV, DCI, and outcome. METHODS: We reviewed 390 patients with ruptured aneurysms who had been treated surgically by day 3 by the same surgeon (T...
March 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29566065/molecular-prediction-of-adjuvant-cisplatin-efficacy-in-non-small-cell-lung-cancer-nsclc-validation-in-two-independent-cohorts
#4
Ida Kappel Buhl, Eric Santoni-Rugiu, Jesper Ravn, Anker Hansen, Ib Jarle Christensen, Thomas Jensen, Bruce Pratt, Jon Askaa, Peter Buhl Jensen, Steen Knudsen, Jens Benn Sørensen
INTRODUCTION: Effective predictive biomarkers for selection of patients benefiting from adjuvant platinum-based chemotherapy in non-small cell lung cancer (NSCLC) are needed. Based on a previously validated methodology, molecular profiles of predicted sensitivity in two patient cohorts are presented. METHODS: The profiles are correlations between in vitro sensitivity to cisplatin and vinorelbine and baseline mRNA expression of the 60 cell lines in the National Cancer Institute panel...
2018: PloS One
https://www.readbyqxmd.com/read/29548449/examination-of-marine-and-vegetable-oil-oxidation-data-from-a-multi-year-third-party-database
#5
Anna A De Boer, Adam Ismail, Keri Marshall, Gerard Bannenberg, Kevin L Yan, William J Rowe
Fish oil (FO) products constitute good sources of omega-3 fats. Oxidation data from a large third-party database of 1900 + globally-sourced FO samples were assessed. In FO products, for peroxide value (PV), 13.9% exceeded 5 mEq O2 /kg (2.2% >10); for acid value (AcV) 2.1% exceeded 3 mg KOH/g, while for p-anisidine value (pAV) in unflavoured oils, 6.1% exceeded 20, (3.8% >30), and 8.8% exceeded TOTOX limits (26). Additionally, we compared FO with other dietary oils. The FO median PV was similar to those of algal and sunflower oils, 4...
July 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29491485/difference-of-uveal-parameters-between-the-acute-primary-angle-closure-eyes-and-the-fellow-eyes
#6
Xingyi Li, Wei Wang, Wenbin Huang, Shida Chen, Jiawei Wang, Zhonghao Wang, Yaoming Liu, Mingguang He, Xiulan Zhang
PURPOSE: To measure the anterior and posterior ocular biometric characteristics concurrently and to explore the relationship between iris, ciliary body and choroid in acute primary angle closure eyes (APAC) and fellow eyes. METHODS: It is a prospective, cross-sectional study. Thirty patients with recent APAC were finally enroled in it. Anterior and posterior uveal parameters were measured simultaneously by anterior segment optical coherence tomography (AS-OCT), swept-source optical coherence tomography (SS-OCT) and ultrasound biomicroscopy (UBM)...
March 1, 2018: Eye
https://www.readbyqxmd.com/read/29445974/impact-of-acquisition-and-interpretation-on-total-inter-observer-variability-in-echocardiography-results-from-the-quality-assurance-program-of-the-staab-cohort-study
#7
Caroline Morbach, Götz Gelbrich, Margret Breunig, Theresa Tiffe, Martin Wagner, Peter U Heuschmann, Stefan Störk
Variability related to image acquisition and interpretation is an important issue of echocardiography in clinical trials. Nevertheless, there is no broadly accepted standard method for quality assessment of echocardiography in clinical research reports. We present analyses based on the echocardiography quality-assurance program of the ongoing STAAB cohort study (characteristics and course of heart failure stages A-B and determinants of progression). In 43 healthy individuals (mean age 50 ± 14 years; 18 females), duplicate echocardiography scans were acquired and mutually interpreted by one of three trained sonographers and an EACVI certified physician, respectively...
February 14, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29444978/an-off-target-effect-of-bx795-blocks-herpes-simplex-virus-type-1-infection-of-the-eye
#8
Dinesh Jaishankar, Abraam M Yakoub, Tejabhiram Yadavalli, Alex Agelidis, Neel Thakkar, Satvik Hadigal, Joshua Ames, Deepak Shukla
Herpes simplex virus type 1 (HSV-1) causes recurrent mucocutaneous lesions in the eye that may advance to corneal blindness. Nucleoside analogs exemplified by acyclovir (ACV) form the primary class of antiherpetic drugs, but this class suffers limitations due to the emergence of viral resistance and other side effects. While studying the molecular basis of ocular HSV-1 infection, we observed that BX795, a commonly used inhibitor of TANK-binding kinase 1 (TBK1), strongly suppressed infection by multiple strains of HSV-1 in transformed and primary human cells, cultured human and animal corneas, and a murine model of ocular infection...
February 14, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29438122/corneal-and-anterior-chamber-morphology-in-human-immunodeficiency-virus-1-infected-patients-without-opportunistic-infections
#9
Ebru N Cetin, Selda Sayın Kutlu, Osman Parca, Murat Kutlu, Gökhan Pekel
OBJECTIVES: To evaluate corneal and anterior chamber morphology as measured by Pentacam HR in human immunodeficiency virus (HIV)-infected patients without opportunistic infections and to search for signs of accelerated aging. METHODS: This prospective study included 41 eyes of 41 HIV-1-infected patients (study group) and 50 eyes of 50 healthy subjects (control group). Specular microscope and Pentacam HR were used for corneal and anterior chamber morphology evaluation...
February 12, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29427675/relevance-of-non-synonymous-thymidine-kinase-mutations-for-antiviral-resistance-of-recombinant-herpes-simplex-virus-type-2-strains
#10
Anne-Kathrin Brunnemann, Anja Hoffmann, Stefanie Deinhardt-Emmer, Claus-Henning Nagel, Ruben Rose, Helmut Fickenscher, Andreas Sauerbrei, Andi Krumbholz
Therapy or prophylaxis of herpes simplex virus type 2 (HSV-2) infections with the nucleoside analog aciclovir (ACV) can lead to the emergence of drug-resistant HSV-2 strains, particularly in immunocompromised patients. In this context, multiple amino acid (aa) changes can accumulate in the ACV-converting viral thymidine kinase (TK) which hampers sequence-based diagnostics significantly. In this study, the so far unknown or still doubted relevance of several individual aa changes for drug resistance in HSV-2 was clarified...
February 7, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29408328/ribociclib-a-cdk4-cdk6-kinase-inhibitor-enhances-glucocorticoid-sensitivity-in-b-acute-lymphoblastic-leukemia-b-all
#11
Roberta Bortolozzi, Elena Mattiuzzo, Luca Trentin, Benedetta Accordi, Giuseppe Basso, Giampietro Viola
Dysregulation of the cyclin D1-CDK4/CDK6 complex is frequently observed in almost all human cancer and contributes to aberrant cell proliferation and consequent tumorigenesis. Although many reports described the importance of CDK4/CDK6 in different set of human tumors, only few studies have been performed on leukemia. By gene expression analysis performed in a cohort of childhood patients affected by B-acute lymphoblastic leukemia (B-ALL) we found that both CDK4 and CDK6 are highly expressed. Moreover, reverse phase protein array (RPPA) analysis showed that cyclin D1 levels are higher in patients undergoing relapse...
February 3, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29394198/distribution-of-anterior-chamber-parameters-in-normal-chinese-children-and-the-associated-factors
#12
Jing Wang, Xiangui He, Shuyu Xiong, Minwen Zhou, Mingjin Wang, Haidong Zou, Xun Xu
PURPOSE: To describe the distribution of anterior chamber depth (ACD), anterior chamber volume (ACV) and anterior chamber angle (ACA) and establish the associated factors in the pediatric population in Shanghai, China. METHODS: In this cross-sectional study, children aged 6 to 18 years from nine primary and middle schools in Shanghai were enrolled. The Pentacam Scheimpflug camera was used to measure anterior eye chamber parameters. The distribution of ACD, ACV, ACA and their associations with age, gender, body mass index, cycloplegic refractive error, axial length, intraocular pressure and other parameters were analyzed...
February 1, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29389629/detection-of-shiga-toxin-producing-escherichia-coli-stec-in-ground-beef-and-bean-sprouts-evaluation-of-culture-enrichment-conditions
#13
Giulia Amagliani, Luca Rotundo, Elisa Carloni, Enrica Omiccioli, Mauro Magnani, Giorgio Brandi, Pina Fratamico
The main purpose of this work was to evaluate culture enrichment conditions, with particular regard to those reported in ISO/TS 13136:2012, for STEC detection in food. The culture media evaluated included mTSB with novobiocin 0-16mg/l (mTSB+N0-16) or acriflavin 12mg/l (mTSB+A12); BPW; mBPWp with acriflavin 10mg/l, cefsulodin 10mg/l, vancomycin 8mg/l (mBPWp+ACV); and mBPWp with cefsulodin 10mg/l, vancomycin 8mg/l (mBPWp+CV). They were used for the growth of STEC O157, O26, O103, O111, O145 and O104 in pure cultures or in artificially contaminated food matrices (ground beef, mung bean sprouts)...
January 2018: Food Research International
https://www.readbyqxmd.com/read/29379012/antimicrobial-activity-of-apple-cider-vinegar-against-escherichia-coli-staphylococcus-aureus-and-candida-albicans-downregulating-cytokine-and-microbial-protein-expression
#14
Darshna Yagnik, Vlad Serafin, Ajit J Shah
The global escalation in antibiotic resistance cases means alternative antimicrobials are essential. The aim of this study was to investigate the antimicrobial capacity of apple cider vinegar (ACV) against E. coli, S. aureus and C. albicans. The minimum dilution of ACV required for growth inhibition varied for each microbial species. For C. albicans, a 1/2 ACV had the strongest effect, S. aureus, a 1/25 dilution ACV was required, whereas for E-coli cultures, a 1/50 ACV dilution was required (p < 0.05)...
January 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29376230/anterior-segment-changes-during-accommodation-in-accommodative-esotropia
#15
Mustafa Koç, Hakan Halit Yaşar, Mehmet Murat Uzel, Salih Çolak, Irfan Durukan, Pelin Yılmazbaş
PURPOSE: To evaluate the anterior segment biometric parameters of non-accommodative and accommodative refractive accommodative esotropia (RAE). METHODS: Eighty-one eyes of 81 patients were included in this prospective, case-control study. The patients were divided into three groups as follows: the RAE group (n = 31), the hypermetropia group (n = 25), and the emmetropia group (n = 25). Measurements were obtained in the non-accommodative (0.0 diopters) and accommodative status (-5...
February 2018: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/29368175/differential-proteomics-for-distinguishing-ischemic-stroke-from-controls-a-pilot-study-of-the-spectra-project
#16
A M Penn, V Saly, A Trivedi, M L Lesperance, K Votova, A M Jackson, N S Croteau, R F Balshaw, M B Bibok, D S Smith, K K Lam, J Morrison, L Lu, S B Coutts, C H Borchers
A diagnostic blood test for stroke is desirable but will likely require multiple proteins rather than a single "troponin." Validating large protein panels requires large patient numbers. Mass spectrometry (MS) is a cost-effective tool for this task. We compared differences in the abundance of 147 protein markers to distinguish 20 acute cerebrovascular syndrome (ACVS) patients who presented to the Emergency Department of one urban hospital within < 24 h from onset) and from 20 control patients who were enrolled via an outpatient neurology clinic...
January 24, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29365137/comparison-of-commercial-lures-and-food-baits-for-early-detection-of-fruit-infestation-risk-by-drosophila-suzukii-diptera-drosophilidae
#17
Dong H Cha, Stephen P Hesler, Anna K Wallingford, Faruque Zaman, Peter Jentsch, Jan Nyrop, Gregory M Loeb
Drosophila suzukii (Matsumura; Diptera: Drosophilidae) is one of the most serious invasive pests of berries and cherries worldwide. Several adult monitoring systems are available to time foliar application of insecticides with the expectation of detecting the presence of D. suzukii before they infest susceptible crops. We tested this by comparing four different trapping systems based on two homemade baits, apple cider vinegar (ACV) or fermenting dough, and two fermentation volatile-based commercial lures, Scentry and Trécé...
April 2, 2018: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29337163/utility-of-ultra-deep-sequencing-for-detection-of-varicella-zoster-virus-antiviral-resistance-mutations
#18
Mélanie Mercier-Darty, David Boutolleau, Raphaël Lepeule, Christophe Rodriguez, Sonia Burrel
We report the first application of ultra-deep sequencing (UDS) to varicella-zoster virus (VZV) genotypic antiviral testing in a case of acyclovir-resistant VZV infection initially detected by Sanger sequencing within a deeply immunocompromised heart transplant recipient. As added-value compared to Sanger analysis, UDS revealed complex dynamics of viral population under antiviral pressure. Varicella-zoster virus (VZV) is a ubiquitous human herpesvirus affecting populations worldwide. VZV is commonly acquired in youth whose primary infection usually manifests as benign varicella (chickenpox)...
March 2018: Antiviral Research
https://www.readbyqxmd.com/read/29291454/nanoscale-determination-of-antiviral-drug-acyclovir-engaging-bifunctionality-of-single-walled-carbon-nanotubes-nafion-film
#19
Pravin Tarlekar, Afsan Khan, Sanghamitra Chatterjee
An elementary and exemplary approach is proposed for the accurate monitoring of antiviral drug acyclovir (ACV) utilizing glassy carbon electrode (GCE) fabricated with single-walled carbon nanotubes and nafion composite film employing square wave voltammetry for the first time. The developed sensor exhibits effective and sustained electron mediating behavior displaying higher peak currents at lower potential than those obtained at bare GCE. At optimal experimental conditions, oxidation current showed a wide linear response for ACV in the concentration range from 10 nM to 30 μM...
March 20, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29280159/a-profile-of-morbidity-and-mortality-rounds-within-resident-training-programs-of-the-american-college-of-veterinary-surgeons
#20
Philip J Kieffer, P O Eric Mueller
OBJECTIVE: To describe the structure and role of morbidity and mortality rounds (MMR) in resident training programs of the American College of Veterinary Surgeons (ACVS). STUDY DESIGN: Cross-sectional analysis: survey. SAMPLE POPULATION: ACVS surgical resident program directors. METHODS: Electronic surveys consisting of 27 questions were sent to the directors of 142 ACVS resident programs. RESULTS: Forty-five (31...
December 27, 2017: Veterinary Surgery: VS
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