keyword
MENU ▼
Read by QxMD icon Read
search

surgery small animal

keyword
https://www.readbyqxmd.com/read/28414565/new-regenerative-vascular-grafts-for-hemodialysis-access-evaluation-of-a-preclinical-animal-model
#1
Karen Tatiana Valencia Rivero, Juliana Jaramillo Escobar, Sergio David Galvis Forero, Maria Clara Miranda Saldaña, Rocío Del Pilar López Panqueva, Néstor Fernando Sandoval Reyes, Juan Carlos Briceño Triana
The purpose of this study was to evaluate a suitable animal model for the in vivo evaluation of patency and vascular tissue regeneration in small intestinal submucosa (SIS) vascular grafts for hemodialysis access. First, a 4-mm U-shaped SIS vascular graft was implanted between the internal carotid artery (CA) and the external jugular vein (JV) in five sheep and six swine. The U-shape grafts remained functional for 53 ± 4 days in sheep and 32 ± 2 days in swine. The sheep model presented exaggerated inflammation, so the swine model was selected for the in vivo study...
April 17, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28395956/benefit-of-an-implanted-solid-barrier-for-the-feasibility-of-a-sequence-of-three-different-hepato-biliary-operations-in-a-small-animal-model
#2
B Richter, C Sänger, F Mussbach, H Scheuerlein, U Settmacher, U Dahmen
BACKGROUND: Current liver surgery includes complex multi-stage procedures such as portal vein ligation (PVL) followed by extended liver resection, especially in patients with Klatskin tumours. The risk for severe adhesions increases with every procedure. Finally, this complex sequence could fail because of malignant adhesions. Therefore, we proved the hypothesis of reducing malignant adhesions and increasing feasibility of a sequence with three hepato-biliary operations by implantation of a solid barrier...
April 8, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/28390181/perceptions-and-opinions-of-canadian-pet-owners-about-anaesthesia-pain-and-surgery-in-small-animals
#3
P V Steagall, B P Monteiro, H L M Ruel, G Beauchamp, G Luca, J Berry, S Little, E Stiles, S Hamilton, D Pang
OBJECTIVES: The aim of this study was to evaluate the perceptions and opinions of Canadian pet owners about anaesthesia, pain and surgery in dogs and cats. METHODS: Six Canadian veterinary hospitals participated. Each practice received 200 copies of a questionnaire that were distributed to pet owners. Questions regarding the use of analgesics, anaesthesia, surgery and onychectomy (cats) were included. Responses were transformed into ordinal scores and analysed with a Cochran-Mantel-Haenszel test...
April 8, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28356120/in-vivo-tspo-and-cannabinoid-receptor-type-2-availability-early-in-post-stroke-neuroinflammation-in-rats-a-positron-emission-tomography-study
#4
Teruyo Hosoya, Dai Fukumoto, Takeharu Kakiuchi, Shingo Nishiyama, Shigeyuki Yamamoto, Hiroyuki Ohba, Hideo Tsukada, Takatoshi Ueki, Kohji Sato, Yasuomi Ouchi
BACKGROUND: Upregulated levels of 18-kDa translocator proteins (TSPO) and type 2 endocannabinoid receptors (CB2) are considered to reflect different aspects of microglia-related neuroinflammatory responses in the brain. Relative to the increase in the TSPO expression that occurs slightly later during neuroinflammation in a proinflammatory fashion, CB2 activation is considered to relate to the neuroprotective responses that occurs predominantly at an early stage of brain disorders. These findings, however, were deduced from studies with different animal samples under different experimental settings...
March 29, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28348787/staphylococcus-caprae-native-mitral-valve-infective-endocarditis
#5
T'ng Choong Kwok, Jennifer Poyner, Ewan Olson, Peter Henriksen, Oliver Koch
INTRODUCTION: Staphylococcus caprae is a rare cause of infective endocarditis. Here, we report a case involving the native mitral valve in the absence of an implantable cardiac electronic device. CASE PRESENTATION: A 76-year-old man presented with a 2 week history of confusion and pyrexia. His past medical history included an open reduction and internal fixation of a humeral fracture 17 years previously, which remained non-united despite further revision 4 years later...
October 2016: JMM Case Reports
https://www.readbyqxmd.com/read/28342287/longitudinal-evaluation-of-perfusion-changes-in-acute-and-chronic-renal-allograft-rejection-using-arterial-spin-labeling-in-translational-mouse-models
#6
Katja Hueper, Martina Schmidbauer, Anja Thorenz, Jan H Bräsen, Marcel Gutberlet, Michael Mengel, Dagmar Hartung, Rongjun Chen, Martin Meier, Hermann Haller, Frank Wacker, Song Rong, Faikah Gueler
PURPOSE: To examine the longitudinal changes of renal perfusion due to acute and chronic renal allograft rejection by using arterial spin labeling (ASL) MRI in translational mouse models of isogenic and allogenic kidney transplantation (ktx). MATERIALS AND METHODS: Acute rejection was induced by allogenic ktx of C57BL/6 (B6)-kidney grafts to BALB/c-recipients with prolonged cold ischemia (CIT) of 60 minutes (n = 13). To induce chronic rejection BALB/c-kidneys were transplanted into B6-recipients with short CIT of 30 minutes (n = 22)...
March 25, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28339120/accessing-structurally-diverse-near-infrared-cyanine-dyes-for-folate-receptor-targeted-cancer-cell-staining
#7
Sandra G König, Roland Krämer
Folate receptor (FR) targeting is one of the most promising strategies for the development of small-molecule based cancer imaging agents since the FR is highly overexpressed on the surface of many cancer cell types. FR-targeted conjugates of NIR emissive cyanine dyes are in advanced clinical trials for fluorescence-guided surgery and are valuable research tools for optical molecular imaging in animal models. Only a small number of promising conjugates has been evaluated so far. Analysis of structure-performance relations to identify critical factors modulating the performance of targeted conjugates is essential for successful further optimization...
March 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28336321/the-histological-and-histomorphometric-changes-in-the-mandible-after-radiotherapy-an-animal-model
#8
Lucas J Poort, Johan H B Ludlage, Nienke Lie, Roland A Böckmann, Jim C E Odekerken, Frank J Hoebers, Peter A W H Kessler
PURPOSE: Approximately 5% of irradiated head and neck cancer patients develop osteoradionecrosis of the mandible. The current non-surgical treatment options for osteoradionecrosis have limited effects and are based on a small number of studies. Therefore, we aimed to enhance the understanding of the pathophysiology of osteoradionecrosis by investigating changes induced by external irradiation in mini-pigs. METHODS: Sixteen Göttingen mini-pigs were divided into four groups for the application in two fractions with total equivalent radiation dosages of 25, 50, 70 Gray, and one group served as control...
February 20, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28323640/a-micro-scale-printable-nanoclip-for-electrical-stimulation-and-recording-in-small-nerves
#9
Charles A Lissandrello, Winthrop F Gillis, Jun Shen, Ben W Pearre, Flavia Vitale, Matteo Pasquali, Bradley J Holinski, Daniel J Chew, Alice E White, Timothy J Gardner
OBJECTIVE: The vision of bioelectronic medicine is to treat disease by modulating the signaling of visceral nerves near various end organs. In small animal models, the nerves of interest can have small diameters and limited surgical access. New high-resolution methods for building nerve interfaces are desirable. In this study, we present a novel nerve interface and demonstrate its use for stimulation and recording in small nerves. APPROACH: We design and fabricate micro-scale electrode-laden nanoclips capable of interfacing with nerves as small as 50 µm in diameter...
March 21, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28306484/evaluation-of-the-economic-and-clinical-feasibility-of-introducing-rigid-endoscopy-and-laparoscopy-to-a-small-animal-general-practice
#10
Kelly Jones, J Brad Case, Brian Evans, Eric Monnet
OBJECTIVE To evaluate the economic and clinical feasibility of introducing rigid endoscopy and laparoscopy to a small animal general practice. DESIGN Prospective study. SAMPLE A single 2-veterinarian small animal practice in southern California. PROCEDURES In early 2012, endoscopic equipment was purchased, and both veterinarians in the practice undertook training in rigid endoscopic and laparoscopic procedures. Subsequently, information for client-owned animals that underwent endoscopic and laparoscopic procedures during a 12-month period (2012 to 2013) was collected...
April 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28300869/e-selectin-inhibition-with-gmi-1271-decreases-venous-thrombosis-without-profoundly-affecting-tail-vein-bleeding-in-a-mouse-model
#11
Dorian L Culmer, Misha L Dunbar, Angela E Hawley, Suman Sood, Robert E Sigler, Peter K Henke, Thomas W Wakefield, John L Magnani, Daniel D Myers
Selectins, such as E-selectin (CD62E), function in venous thrombosis by binding and activating immune cells to initiate the coagulation cascade. GMI-1271 is a small molecule antagonist that inhibits E-selectin activity. Here we determine whether inhibition of E-selectin is sufficient to decrease acute venous thrombosis and associated inflammatory events in both prophylactic and treatment protocols without significantly affecting haemostasis. Male C57BL/6 mice underwent surgery for experimental thrombosis induction and were harvested at peak thrombus formation in our animal model, two days post induction...
March 16, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28292311/sonography-of-the-distal-urethra-in-lambs
#12
Ammar AlLugami, Kerstin von Pückler, Axel Wehrend, Marlene Sickinger
Sonography is a convenient, non-invasive diagnostic modality in small ruminants, often used in reproductive management, internal medicine, and surgery. Pregnancy diagnostics and imaging anatomy and pathology of organs, such as neoplasia, are major applications. Urolithiasis is one of the most common causes of death in male sheep and goats, for which sonography is the diagnostic modality of choice. Although ultrasound-imaging techniques for kidneys, ureters, and urinary bladder in small ruminants have been described previously, this study focuses on reporting the imaging technique of the extra-pelvic portion of the urethra, as nearly all the cases of obstructive urolithiasis result from urinary stones in this part...
March 14, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28283668/effect-of-peritoneal-lavage-solution-temperature-on-body-temperature-in-anaesthetised-cats-and-small-dogs
#13
D C Barnes, E A Leece, T A Trimble, J L Demetriou
A prospective, randomised, non-blinded, clinical study to assess the effect of peritoneal lavage using warmed fluid on body temperature in anesthetised cats and dogs of less than 10 kg body mass undergoing coeliotomy. A standardised anaesthetic protocol was used. Oesophageal and rectal temperatures were measured at various time points. At the end of surgery, group 1 patients (n=10) were lavaged with 200 ml/kg sterile isotonic saline at 34±1°C and group 2 (n=10) at 40±1°C. Groups were similar with respect to age, mass, body condition and surgical incision length...
March 10, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28273656/animal-models-for-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-alpps-achievements-and-future-perspectives
#14
Andras Budai, Andras Fulop, Oszkar Hahn, Peter Onody, Tibor Kovacs, Tibor Nemeth, Miklos Dunay, Attila Szijarto
BACKGROUND: Since 2012, Associated Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) has been standing in the limelight of modern liver surgery and numerous questions have been raised regarding this novel approach. On the one hand, ALPPS has proved to be a valuable method in the treatment of hepatic tumors, while on the other hand, there are many controversies, such as high mortality and morbidity rates. Further surgical research is essential for a better understanding of underlying mechanisms and for enhancing patient safety...
March 9, 2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/28270519/plasminogen-activator-inhibitor-1-regulates-macrophage-dependent-postoperative-adhesion-by-enhancing-egf-her1-signaling-in-mice
#15
Kumpei Honjo, Shinya Munakata, Yoshihiko Tashiro, Yousef Salama, Hiroshi Shimazu, Salita Eiamboonsert, Douaa Dhahri, Atsuhiko Ichimura, Takashi Dan, Toshio Miyata, Kazuyoshi Takeda, Kazuhiro Sakamoto, Koichi Hattori, Beate Heissig
Adhesive small bowel obstruction remains a common problem for surgeons. After surgery, platelet aggregation contributes to coagulation cascade and fibrin clot formation. With clotting, fibrin degradation is simultaneously enhanced, driven by tissue plasminogen activator-mediated cleavage of plasminogen to form plasmin. The aim of this study was to investigate the cellular events and proteolytic responses that surround plasminogen activator inhibitor (PAI-1; Serpine1) inhibition of postoperative adhesion. Peritoneal adhesion was induced by gauze deposition in the abdominal cavity in C57BL/6 mice and those that were deficient in fibrinolytic factors, such as Plat(-/-) and Serpine1(-/-) In addition, C57BL/6 mice were treated with the novel PAI-1 inhibitor, TM5275...
March 7, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28266749/the-effect-of-glucagon-like-peptide-1-and-glucagon-like-peptide-2-on-microcirculation-a-systematic-review
#16
REVIEW
Nikolaj Nerup, Rikard Ambrus, Joanna Lindhe, Michael P Achiam, Palle B Jeppesen, Lars B Svendsen
OBJECTIVE: Glucagon-like peptide-1 (GLP-1) and -2 (GLP-2) are gut-derived hormones used in the treatment of diabetes type-2 and short bowel syndrome, respectively. GLP-1 attenuates insulin resistance and GLP-2 reduces enterocyte apoptosis and enhances crypt cell proliferation in the small intestine. In addition, both hormones have vasoactive effects and may be useful in situations with impaired microcirculation. The aim of this systematic review was to provide an overview of the potential effects of GLP-1 and GLP-2 on microcirculation...
March 7, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28266040/ex-vivo-porcine-organ-perfusion-models-as-a-suitable-platform-for-translational-transplant-research
#17
Rohan Kumar, Wen Yuan Chung, Ashley Robert Dennison, Giuseppe Garcea
In transplantation surgery, extending the criteria for organ donation to include organs that may have otherwise been previously discarded has provided the impetus to improve organ preservation. The traditional method of cold static storage (CS) has been tried and tested and is suitable for organs meeting standard criteria donation. Ex vivo machine perfusion is, however, associated with evidence suggesting that it may be better than CS alone and may allow for organ donation criteria to be extended. Much of our knowledge of organ preservation is derived from animal studies...
March 6, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28263385/intraoperative-near-infrared-fluorescence-imaging-targeting-folate-receptors-identifies-lung-cancer-in-a-large-animal-model
#18
Jane J Keating, Jeffrey J Runge, Sunil Singhal, Sarah Nims, Ollin Venegas, Amy C Durham, Gary Swain, Shuming Nie, Philip S Low, David E Holt
BACKGROUND: Complete tumor resection is the most important predictor of patient survival with non-small cell lung cancer. Methods for intraoperative margin assessment after lung cancer excision are lacking. This study evaluated near-infrared (NIR) intraoperative imaging with a folate-targeted molecular contrast agent (OTL0038) for the localization of primary lung adenocarcinomas, lymph node sampling, and margin assessment. METHODS: Ten dogs with lung cancer underwent either video-assisted thoracoscopic surgery or open thoracotomy and tumor excision after an intravenous injection of OTL0038...
May 15, 2017: Cancer
https://www.readbyqxmd.com/read/28248041/-urinary-bladder-substitution-using-combined-membrane-based-on-secretions-of-human-mesenchymal-stem-cells-and-type-i-collagen
#19
V I Kirpatovckii, D M Kamalov, A Yu Efimenko, P I Makarevich, G D Sagaradze, O A Makarevich, P P Nimiritskii, E O Osidak, S P Domogatskii, V K Karpov, Z H A Akopyan, V A Tkachuk, A A Kamalov
AIM: Despite the widespread use of intestinal cystoplasty, urinary bladder substitution remains a challenging problem due to the complexity of operations and the potentially high risk of complications. A promising alternative may be bio-engineered collagen-based matrices containing stem cells or their secretions. MATERIAL AND METHODS: To evaluate the effectiveness of this bladder substitution modality, an experiment was conducted on 14 male rabbits. The animals underwent resection of urinary bladder, and the formed defect was substituted with a membrane of type I collagen (series 1, 5 rabbits) or a membrane of the same composition containing a conditioned medium with secretion of mesenchymal stem/stromal cells derived from human adipose tissue (series 2, 5 rabbits)...
December 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28243794/discrete-tomography-in-an-in-vivo-small-animal-bone-study
#20
Elke Van de Casteele, Egon Perilli, Wim Van Aarle, Karen J Reynolds, Jan Sijbers
This study aimed at assessing the feasibility of a discrete algebraic reconstruction technique (DART) to be used in in vivo small animal bone studies. The advantage of discrete tomography is the possibility to reduce the amount of X-ray projection images, which makes scans faster and implies also a significant reduction of radiation dose, without compromising the reconstruction results. Bone studies are ideal for being performed with discrete tomography, due to the relatively small number of attenuation coefficients contained in the image [namely three: background (air), soft tissue and bone]...
February 27, 2017: Journal of Bone and Mineral Metabolism
keyword
keyword
104343
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"