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https://www.readbyqxmd.com/read/28228071/a-rat-model-of-ischemic-enteritis-pathogenic-importance-of-enterobacteria-inos-no-and-cox-2-pge2
#1
Koji Takeuchi, Yoshino Komatsu, Yuka Nakamori, Tohru Kotani
BACKGROUND: We introduced a rat model of ischemic enteritis and investigated the roles of enterobacteria, nitric oxide (NO), and prostaglandins (PGs) in its pathogenesis. METHODS: Male rats were used after 18 h of fasting. Ischemic enteritis was induced by partial ligation of the superior mesenteric artery (SMA). Under ether anesthesia, SMA was isolated, and a stenosis was made by placing a needle (23 guage) on the vessel and ligating both the vessel and needle, and then a needle was removed from the ligature...
February 20, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28196035/perivascular-stem-cells-diminish-muscle-atrophy-following-massive-rotator-cuff-tears-in-a-small-animal-model
#2
Claire D Eliasberg, Ayelet Dar, Andrew R Jensen, Iain R Murray, Winters R Hardy, Tomasz J Kowalski, Cameron A Garagozlo, Kyle M Natsuhara, Adam Z Khan, Owen J McBride, Peter I Cha, Benjamin V Kelley, Denis Evseenko, Brian T Feeley, David R McAllister, Bruno Péault, Frank A Petrigliano
BACKGROUND: Rotator cuff tears are a common cause of shoulder pain and often necessitate operative repair. Muscle atrophy, fibrosis, and fatty infiltration can develop after rotator cuff tears, which may compromise surgical outcomes. This study investigated the regenerative potential of 2 human adipose-derived progenitor cell lineages in a murine model of massive rotator cuff tears. METHODS: Ninety immunodeficient mice were used (15 groups of 6 mice). Mice were assigned to 1 of 3 surgical procedures: sham, supraspinatus and infraspinatus tendon transection (TT), or TT and denervation via suprascapular nerve transection (TT + DN)...
February 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28192280/iterative-reconstruction-of-sipm-light-response-functions-in-a-square-shaped-compact-gamma-camera
#3
Andrey Morozov, Francisco Alves, Joao Marcos, Raimundo Martins, Luis Pereira, Vladimir Solovov, Vitaly Chepel
Compact gamma cameras with a square-shaped monolithic scintillator crystal and an array of silicon photomultipliers (SiPMs) are actively being developed for applications in areas such as small animal imaging, cancer diagnostics and radiotracer guided surgery. Statistical methods of position reconstruction, which are potentially superior to the traditional centroid method, require accurate knowledge of the spatial response of each photomultiplier. Using both Monte Carlo simulations and experimental data obtained with a camera prototype, we show that the spatial response of all photomultipliers (light response functions) can be parameterized with axially symmetric functions obtained iteratively from flood field irradiation data...
February 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28167230/adaptation-to-a-blood-pressure-telemetry-system-revealed-by-measures-of-activity-agility-and-operant-learning-in-mice
#4
Anfisa Popova, Darya Tsvirkun, Oleg Dolgov, Konstantin Anokhin, Jeffrey Alberts, Evgeniia Lagereva, Marc-Antoine Custaud, Guillemette Gauquelin-Koch, Olga Vinogradova, Alexander Andreev-Andrievskiy
INTRODUCTION: Implantable telemetry enables continuous monitoring of physiological functions in freely moving animals and can greatly complement pharmacological research. Despite its miniaturization, a sensor/transmitter constitutes 5% or more of a mouse's bodyweight. The aim of the present study was to evaluate whether factors related to the presence of a probe/transmitter influence the ambulatory activity, strength, agility, or operant, motivated behaviors of this small rodent. METHODS: Adult male mice (C57BL/6N, 22-25g, 9-10weeks; implanted n=26, intact n=45) were evaluated during week-long tests, conducted three and eight weeks after surgical implantation of the PA-C10 blood pressure probe...
February 3, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28150063/small-intestinal-bypass-induces-a-persistent-weight-loss-effect-and-improves-glucose-tolerance-in-obese-rats
#5
Jiaqing Cao, Quan Ren, Cai Tan, Jinyuan Duan
BACKGROUND: This study investigated the role of proximal small intestinal bypass (PSIB) and distal small intestinal bypass (DSIB) as well as their long-term effects on weight loss and glucose metabolism in high-sugar and high-fat diet-induced obese rats. METHODS: Sprague-Dawley rats were divided into four groups: PSIB, bypassing 60% of the proximal small intestine length; DSIB, bypassing 60% of the distal small intestine length; sham-operated (Sham) animals; and control animals...
February 1, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28147365/measurement-of-fibrosis-in-crohn-s-disease-strictures-with-imaging-and-blood-biomarkers-to-inform-clinical-decisions
#6
REVIEW
Peter D R Higgins
BACKGROUND: Distinguishing fibrosis from inflammation in an intestinal stricture in Crohn's disease is quite difficult. The absence of signs of inflammation on CT or MRI does not prove the absence of inflammation, as most strictures have a mix of fibrosis and inflammation. Identifying refractory fibrosis and distinguishing the patients who will respond to anti-inflammatory therapy from those who will require surgery are important clinical requirements, and several new technologies in imaging and serum biomarkers are being applied to this problem...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28137632/generation-6-hydroxyl-pamam-dendrimers-improve-cns-penetration-from-intravenous-administration-in-a-large-animal-brain-injury-model
#7
Fan Zhang, J Trent Magruder, Yi-An Lin, Todd C Crawford, Joshua C Grimm, Christopher M Sciortino, Mary Ann Wilson, Mary E Blue, Sujatha Kannan, Michael V Johnston, William A Baumgartner, Rangaramanujam M Kannan
Hypothermic circulatory arrest (HCA) provides neuroprotection during cardiac surgery but entails an ischemic period that can lead to excitotoxicity, neuroinflammation, and subsequent neurologic injury. Hydroxyl polyamidoamine (PAMAM) dendrimers target activated microglia and damaged neurons in the injured brain, and deliver therapeutics in small and large animal models. We investigated the effect of dendrimer size on brain uptake and explored the pharmacokinetics in a clinically-relevant canine model of HCA-induced brain injury...
March 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28119180/teriparatide-attenuates-scarring-around-murine-cranial-bone-allograft-via-modulation-of-angiogenesis
#8
Doron Cohn Yakubovich, Uzi Eliav, Eran Yalon, Yeshai Schary, Dmitriy Sheyn, Galen Cook-Wiens, Shuting Sun, Charles E McKenna, Shaya Lev, Alexander M Binshtok, Gadi Pelled, Gil Navon, Dan Gazit, Zulma Gazit
Nearly all bone fractures in humans can deteriorate into a non-union fracture, often due to formation of fibrotic tissue. Cranial allogeneic bone grafts present a striking example: although seemingly attractive for craniofacial reconstructions, they often fail due to fibrosis at the host-graft junction, which physically prevents the desired bridging of bone between the host and graft and revitalization of the latter. In the present study we show that intermittent treatment with recombinant parathyroid hormone-analogue (teriparatide) modulates neovascularization feeding in the graft surroundings, consequently reducing fibrosis and scar tissue formation and facilitates osteogenesis...
January 21, 2017: Bone
https://www.readbyqxmd.com/read/28110472/surgical-denervation-of-specific-cutaneous-nerves-impedes-excisional-wound-healing-of-small-animal-ear-pinnae
#9
Bhagwat V Alapure, Yan Lu, Hongying Peng, Song Hong
Damage to cutaneous nerves inhibits wound healing in patients. Results from animals on the nerve contributions to healing are various and sometimes contradictory. Here, we aim to clearly define the collective role of central, caudal, and rostral nerves in ear wound healing of mice, rats, and rabbits. These wounds heal with minimal contraction like wounds in humans. We resected central, caudal, and rostral nerves at the base of ear pinnae by microsurgery and created excisional full-thickness skin wounds in the pinnae neurologically downstream from the resections...
January 21, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28099801/highly-specific-and-sensitive-fluorescent-nanoprobes-for-image-guided-resection-of-sub-millimeter-peritoneal-tumors
#10
Aaron H Colby, Samantha M Berry, Ann M Moran, Kristine Amber Pasion, Rong Liu, Yolonda L Colson, Nelson Ruiz-Opazo, Mark W Grinstaff, Victoria L M Herrera
A current challenge in the treatment of peritoneal carcinomatosis is the inability to detect, visualize, and resect small or microscopic tumors of pancreatic, ovarian, or mesothelial origin. In these diseases, the completeness of primary tumor resection is directly correlated with patient survival, and hence, identifying small sub-millimeter tumors (i.e., disseminated disease) is critical. Thus, new imaging techniques and probes are needed to improve cytoreductive surgery and patient outcomes. Highly fluorescent rhodamine-labeled expansile nanoparticles (HFR-eNPs) are described for use as a visual aid during cytoreductive surgery of pancreatic carcinomatosis...
February 1, 2017: ACS Nano
https://www.readbyqxmd.com/read/28072656/isosorbide-induced-decompression-effect-on-the-scala-media-participation-of-plasma-osmolality-and-plasma-arginine-vasopressin
#11
Taizo Takeda, Setsuko Takeda, Natsumi Uehara, Shungaku Yanagisawa, Tatsuya Furukawa, Ken-Ichi Nibu, Akinobu Kakigi
OBJECTIVE: The correlation between the isosorbide-induced decompression effect on the endolymphatic space and plasma osmolality (p-OSM) or plasma arginine vasopressin (p-AVP) was investigated on comparing two different dosages of isosorbide (2.8 and 1.4 g/kg) to elucidate why the decompression effect is delayed with a large dose of isosorbide. MATERIALS AND METHODS: Two experiments were performed using 80 guinea pigs. Experiment 1 was designed to morphologically investigate the sequential influence of the oral intake of 1...
January 9, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28060071/corneal-lenticule-allotransplantation-after-femtosecond-laser-small-incision-lenticule-extraction-in-rabbits
#12
Jing Zhao, Yang Shen, Mi Tian, Ling Sun, Yu Zhao, Xiaoyu Zhang, Xingtao Zhou
PURPOSE: To investigate the feasibility of allotransplanting extracted lenticules after femtosecond laser-assisted small incision lenticule extraction (SMILE) in rabbits and the subsequent healing process. METHODS: Fourteen New Zealand white rabbits were divided evenly into 2 groups. The rabbits in group A received SMILE procedures with a -6.00 D correction. The lenticules from group A were immediately inserted into a femtosecond laser-created corneal stromal pocket in group B...
February 2017: Cornea
https://www.readbyqxmd.com/read/28057033/reducing-the-risk-of-impaired-bone-apposition-to-titanium-screws-with-the-use-of-fibroblast-growth-factor-2-apatite-composite-layer-coating
#13
Kengo Fujii, Atsuo Ito, Hirotaka Mutsuzaki, Shinji Murai, Yu Sogo, Yuki Hara, Masashi Yamazaki
BACKGROUND: Loosening of screws is a common problem in orthopedic and maxillofacial surgery. Modifying the implant surface to improve the mechanical strength of screws has been tried and reported. We developed screws coated with fibroblast growth factor-2 (FGF-2)-apatite composite layers. We then showed, in a percutaneous external fixation model, that this composite layer had the ability to hold and release FGF-2 slowly, thereby reducing the risk of pin tract infection of the percutaneous external fixation...
January 5, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28055036/preparation-and-implementation-of-optofluidic-neural-probes-for-in-vivo-wireless-pharmacology-and-optogenetics
#14
Jordan G McCall, Raza Qazi, Gunchul Shin, Shuo Li, Muhammad Hamza Ikram, Kyung-In Jang, Yuhao Liu, Ream Al-Hasani, Michael R Bruchas, Jae-Woong Jeong, John A Rogers
This Protocol Extension describes the fabrication and technical procedures for implementing ultrathin, flexible optofluidic neural probe systems that provide targeted, wireless delivery of fluids and light into the brains of awake, freely behaving animals. As a Protocol Extension article, this article describes an adaptation of an existing Protocol that offers additional applications. This protocol serves as an extension of an existing Nature Protocol describing optoelectronic devices for studying intact neural systems...
February 2017: Nature Protocols
https://www.readbyqxmd.com/read/27994977/blood-circulation-in-the-ascidian-tunicate-corella-inflata-corellidae
#15
Michael W Konrad
The body of the ascidian tunicate Corella inflata is relatively transparent. Thus, the circulatory system can be visualized by injecting high molecular weight fluorescein labeled dextran into the heart or the large vessels at the ends of the heart without surgery to remove the body wall. In addition, after staining with neutral red, the movement of blood cells can be easily followed to further characterize the circulatory system. The heart is two gently curved concentric tubes extending across the width of the animal...
2016: PeerJ
https://www.readbyqxmd.com/read/27987599/a-preclinical-animal-study-of-a-novel-simple-and-secure-percutaneous-vessel-occluder-for-the-treatment-of-varicose%C3%A2-veins
#16
Arnold Miller, Nir Lilach, Raanan Miller, Lowell Kabnick
BACKGROUND: Secure, permanent occlusion of the great and small saphenous veins, their tributaries, and perforators is critical for the successful treatment of varicose veins. Current minimally invasive methods replacing surgery are all endoluminal and involve heat (radiofrequency or laser), chemicals (sclerosants and glues), or a combination of mechanical and chemical interventions. This study evaluated in a porcine model the performance of a percutaneous delivery of the Amsel Vessel Occluder (AVO; Amsel Medical Corp, Cambridge, Mass) using ultrasound guidance...
January 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/27984781/simvastatin-augments-revascularization-and-reperfusion-in-a-murine-model-of-hind-limb-ischemia-multimodal-imaging-assessment
#17
Julian Luke Goggi, Michael Ng, Nalini Shenoy, Ramasamy Boominathan, Peter Cheng, Sakthivel Sekar, Kishore Kumar Bhakoo
INTRODUCTION: Peripheral artery disease can lead to severe disability and limb loss. Therapeutic strategies focussing on macrovascular repair have shown benefit but have not significantly reduced amputation rates in progressive PAD. Proangiogenic small molecule therapies may substantially improve vascularisation in limb ischemia. The purpose of the current study was to assess the proangiogenic effects of simvastatin in a murine model of hind limb ischemia using longitudinal multimodal imaging...
November 17, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27979758/a-testbed-for-optimizing-electrodes-embedded-in-the-skull-or-in-artificial-skull-replacement-pieces-used-after-injury
#18
JingLe Jiang, Amar R Marathe, Jennifer C Keene, Dawn M Taylor
BACKGROUND: Custom-fitted skull replacement pieces are often used after a head injury or surgery to replace damaged bone. Chronic brain recordings are beneficial after injury/surgery for monitoring brain health and seizure development. Embedding electrodes directly in these artificial skull replacement pieces would be a novel, low-risk way to perform chronic brain monitoring in these patients. Similarly, embedding electrodes directly in healthy skull would be a viable minimally-invasive option for many other neuroscience and neurotechnology applications requiring chronic brain recordings...
February 1, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27958227/establishment-of-a-novel-mouse-model-of-coronary-microembolization
#19
Yuan-Yuan Cao, Zhang-Wei Chen, Jian-Guo Jia, Ao Chen, You Zhou, Yong Ye, Yan-Hua Gao, Yan Xia, Shu-Fu Chang, Jian-Ying Ma, Ju-Ying Qian, Jun-Bo Ge
BACKGROUND: Coronary microembolization (CME) has been frequently seen in acute coronary syndromes and percutaneous coronary intervention. Small animal models are required for further studies of CME related to severe prognosis. This study aimed to explore a new mouse model of CME. METHODS: The mouse model of CME was established by injecting polystyrene microspheres into the left ventricular chamber during 15-s occlusion of the ascending aorta. Based on the average diameter and dosage used, 30 C57BL/6 male mice were randomly divided into five groups (n = 6 in each): 9 μm/500,000, 9 μm/800,000, 17 μm/200,000, 17 μm/500,000, and sham groups...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27956071/solution-blow-spun-polymer-a-novel-preclinical-surgical-sealant-for-bowel-anastomoses
#20
Nora G Kern, Adam M Behrens, Priya Srinivasan, Christopher T Rossi, John L Daristotle, Peter Kofinas, Anthony D Sandler
BACKGROUND: Solution blow spinning is a technique for depositing polymer fibers with promising potential use as a surgical sealant. This study assessed the feasibility and efficacy of solution blow spun polymer (BSP) for sealing bowel perforations in a mouse model of partial cecal transection. We then evaluated its use for reinforcing a surgical anastomosis in a preclinical piglet model. METHODS: Three commercially available surgical sealants (fibrin glue, polyethylene glycol (PEG) hydrogel, and cyanoacrylate) were compared to BSP in the ability to seal partially transected cecum in mice...
December 5, 2016: Journal of Pediatric Surgery
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