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https://www.readbyqxmd.com/read/29319013/intraoperative-cardiovascular-response-of-natural-orifice-transluminal-endoscopic-surgery-versus-laparoscopy-a-comparative-animal-study
#1
Stefan Patrascu, Catalin Andu Copaescu, Valeriu Surlin, Sandu Ramboiu, Alice Nicoleta Dragoescu, Sorin Stanilescu, Dan Cristian, Bogdan Silviu Ungureanu, Daniela Elena Burtea, Ana Maria Patrascu, Florin Turcu, Adrian Saftoiu
BACKGROUND: Natural orifice transluminal endoscopic surgery (NOTES) emerged as a new alternative method in minimally invasive techniques. Although a very small number of studies have compared the physiologic response in NOTES to laparoscopy, the results remain controversial. AIM: This experimental animal study aims to evaluate the intraoperative cardiovascular and respiratory effects of pure transluminal natural orifice surgery and conventional laparoscopy. MATERIALS AND METHODS: Twenty female pigs (Sus scrofa domesticus) equally divided into two study groups were assigned to either pure natural orifice transluminal endoscopic techniques (Group 1) or conventional laparoscopic surgery (Group 2) and monitored intraoperatively in terms of heart rate (HR), systolic blood pressure (SBP) and O2saturation (SpO2) for 1 h...
January 10, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29298608/resorbable-self-locking-implant-for-lung-lobectomy-through-video-assisted-thoracoscopic-surgery-first-live-animal-application
#2
Rogério Luizari Guedes, Odd Viking Höglund, Juliana Sperotto Brum, Niklas Borg, Peterson Triches Dornbusch
The aim of this pilot test was to test a new self-locking resorbable implant for hilum occlusion during a video-assisted thoracoscopic lung lobectomy in a surviving pig model. Once the thoracic cavity was assessed and structures identified, the right middle lobe and its respective hilum were exposed. The implant was introduced with a semiclosed loop through a working channel and positioned around the pulmonary lobe. Occlusion was performed with a conventional Crile forceps and a laparoscopic Kelly forceps. Lobe section was done with laparoscopic Metzenbaum scissors and tissue removal through the dorsal access...
January 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29283288/a-novel-method-for-the-rapid-detection-of-post-translationally-modified-visinin-like-protein-1-in-rat-models-of-brain-injury
#3
Melissa A Bradley-Whitman, Kelly N Roberts, Erin L Abner, Stephen W Scheff, Bert C Lynn, Mark A Lovell
BACKGROUND: Although elevated serum levels of visinin-like protein 1 (VILIP-1), a neuron-specific calcium sensor protein, are associated with ischaemic stroke, only a single study has evaluated VILIP-1 as a biomarker of traumatic brain injury (TBI). The current proof-of-concept study was designed to determine whether serum VILIP-1 levels increase post-injury in a well-characterized rat unilateral cortical contusion model. METHODS: Lateral flow devices (LFDs) rapidly (< 20 min) detected trace serum levels (pg/mL) of VILIP-1 in a small input sample volume (10 µL)...
December 28, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29277591/egg-model-training-protocol-for-stereotaxic-neurosurgery-and-microelectrode-implant
#4
Lorena Andreoli, Hougelle Simplício, Edgard Morya
Neuroscience research often uses neurosurgery in animal models for several experimental techniques. To our knowledge, there is not a published method for small animal neurosurgery training. Since eggshell thickness is similar to mice, rats and some small primates' skull, we hereby propose an egg-model training for stereotaxic surgery. This protocol allows trainees in neuroscience research to familiarize with microsurgery setting and learn neurosurgery techniques, such as craniotomy drilling, dura mater removal, and electrode implantation...
December 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29273364/establishment-of-laparoscopic-live-donor-nephrectomy-in-a-porcine-model-techniques-and-outcomes-in-44-pigs
#5
Mark E Newman, Gabrielle C Musk, Bulang He
BACKGROUND: Laparoscopic live donor nephrectomy has replaced open donor nephrectomy in most patients due to numerous benefits. A live animal model is required to equip surgeons with the necessary skills to perform such a procedure with minimal risk of complications. The aim of this study was to establish the technique for laparoscopic live donor nephrectomy in a porcine (Sus scrofa) model. MATERIALS AND METHODS: This study was approved by the Animal Ethics Committee of the university...
February 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29258403/a-novel-augmented-venous-drainage-model-of-cardiopulmonary-bypass-for-deep-hypothermic-circulatory-arrest-without-blood-priming
#6
Xuan Jiang, Tianxiang Gu, Yu Liu, Chun Wang, Enyi Shi, Guangwei Zhang
OBJECTIVE: Cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA) are commonly used in cardiac surgery. However, the mortality and morbidity are still high in practice. Developing novel protective stategies and elucidating the underlying mechanisms for the pathophysiological consequences of DHCA have been hampered because of the absence of a satisfactory recovery animal model. The aim of this study was to establish a novel and safe DHCA model without blood priming in rats to study the pathophysiology of potential complications...
December 1, 2017: Perfusion
https://www.readbyqxmd.com/read/29249602/surgical-management-of-abomasal-and-small-intestinal-disease
#7
REVIEW
Sylvain Nichols, Gilles Fecteau
A bovine practitioner should master abdominal exploratory surgery (laparotomy). Several gastrointestinal (GI) problems require surgical correction to save the animal's life and to keep it in production. This article reviews the surgical preparation, procedures, and the postoperative care of several conditions affecting the GI tract of cattle.
December 14, 2017: Veterinary Clinics of North America. Food Animal Practice
https://www.readbyqxmd.com/read/29247279/greater-curvature-plication-with-duodenal-jejunal-bypass-a-novel-metabolic-surgery-for-type-2-diabetes-mellitus
#8
Nian-Cun Qiu, Xiao-Xia Cen, Miao-E Liu, Qing Liu, Si-Luo Zha, Cheng-Xiang Shan, Wei Zhang, Ling-Di Wang, Yang Wang, Ming Qiu
OBJECTIVE: The study investigated the use of great curvature plication with duodenal-jejunal bypass (GCP-DJB) in a type 2 diabetic with obesity rat model. METHODS: Twenty-two Sprague-Dawley rats were given a high fat and sugar diet with subsequent intraperitoneal injection of a small dosage of streptozotocin (30 mg/kg) and randomly assigned to either GCP-DJB (n = 12) or Sham surgery (n = 10). Body weight, peripheral blood glucose, and fasting serum insulin were assayed, and insulin resistance index (IRI) was calculated, before and at 1, 2, 4, and 8 weeks after surgery...
December 16, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29246590/developing-a-national-simulation-based-surgical-skills-bootcamp-in-general-thoracic-surgery
#9
Colin Schieman, Hideki Ujiie, Laura Donahoe, Waël Hanna, Richard Malthaner, Simon Turner, Kasia Czarnecka, Kazuhiro Yasufuku
BACKGROUND: The use surgical simulation across all subspecialties has gained widespread adoption in the last decade. A number of factors, including the small number of trainees, identified gaps in surgical skill training from cross-sectional surveys, increased national collaboration, and support from the national specialty committee identified a need to construct a surgical skills "bootcamp" in thoracic surgery in Canada. OBJECTIVE: The goals of the surgical skills bootcamp, as identified by the residency training program directors and the national specialty committee were to create a national, centralized, simulation-based skills workshop that focused on key foundational procedures within thoracic surgery, particularly those identified as areas of weakness by former residents; to smooth the transition to intraoperative teaching; to provide exposure to important but not necessarily universally available procedures such as advanced endoscopy; to teach non-medical expert competencies, and lastly to provide a venue for networking for residents across the country...
December 12, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29244602/association-of-magnetic-resonance-imaging-based-preoperative-tumor-volume-with-postsurgical-survival-time-in-dogs-with-primary-intracranial-glioma
#10
Jeffrey D MacLellan, Susan A Arnold, Aditya C Dave, Matthew A Hunt, G Elizabeth Pluhar
OBJECTIVE To assess the relationship between preoperative volume of primary intracranial gliomas in dogs as determined via MRI and survival time after surgical debulking and adjunctive immunotherapy. DESIGN Retrospective cohort study. ANIMALS 47 client-owned dogs enrolled in clinical trials regarding glioma treatments. PROCEDURES Medical records of all dogs undergoing craniotomy at the University of Minnesota Veterinary Medicine Center with histologically confirmed glioma between 2008 and 2015 were retrospectively reviewed, and outcome data were collected...
January 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29242134/non-contrast-estimation-of-diffuse-myocardial-fibrosis-with-dual-energy-ct-a-phantom-study
#11
Vidhya Kumar, Kevin E McElhanon, James K Min, Xin He, Zhaobin Xu, Eric X Beck, Orlando P Simonetti, Noah Weisleder, Subha V Raman
BACKGROUND: Estimation of diffuse myocardial fibrosis, substrate for adverse events such as heart failure and arrhythmias in patients with various cardiac disorders, is presently done by histopathology or cardiac magnetic resonance. We sought to develop a non-contrast method to estimate the amount of diffuse myocardial fibrosis leveraging dual energy computed tomography (DECT) in phantoms and a suitable small animal model. METHODS AND RESULTS: Phantoms consisted of homogenized bovine myocardium with varying amounts of Type 1 collagen...
December 5, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29237141/lessons-from-the-barn-to-the-operating-suite-a-comprehensive-review-of-animal-models-for-fetal-surgery
#12
Sandra K Kabagambe, Chelsey J Lee, Laura F Goodman, Y Julia Chen, Melissa A Vanover, Diana L Farmer
The International Fetal Medicine and Surgery Society was created in 1982 and proposed guidelines for fetal interventions that required demonstrations of the safety and feasibility of intended interventions in animal models prior to application in humans. Because of their short gestation and low cost, small animal models are useful in early investigation of fetal strategies. However, owing to the anatomic and physiologic differences between small animals and humans, repeated studies in large animal models are usually needed to facilitate translation to humans...
December 13, 2017: Annual Review of Animal Biosciences
https://www.readbyqxmd.com/read/29228960/cross-sectional-survey-on-the-use-and-impact-of-the-danish-national-antibiotic-use-guidelines-for-companion-animal-practice
#13
Lisbeth Rem Jessen, Tina Møller Sørensen, Zenia Littau Lilja, Maja Kristensen, Tine Hald, Peter Damborg
BACKGROUND: The Danish antibiotic use guidelines for companion animal practice were published by the Danish Veterinary Association in 2012. Since then, national surveillance data indicate a 10% reduction in the total use of antibiotics for companion animals, particularly a marked reduction in the use of third generation cephalosporins. The aim of the study was to assess if and how the guidelines have impacted diagnostic and antibiotic prescription habits of the users, and to identify user perceived barriers to implementation...
December 11, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29225893/a-novel-approach-to-glycemic-control-in-type-2-diabetes-mellitus-partial-jejunal-diversion-pre-clinical-to-clinical-pathway
#14
Martin Fried, Karin Dolezalova, Adam P Chambers, Elliott J Fegelman, Robin Scamuffa, Michael L Schwiers, Jason R Waggoner, Martin Haluzik, Randy J Seeley
Objective: To explore partial jejunal diversion (PJD) via a side-to-side jejuno-jejunostomy for improved glycemic control in type 2 diabetes mellitus (T2DM). PJD is an anatomy-sparing, technically simple surgery in comparison to the predominate metabolic procedures, Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). Positive results in a rodent model prompted a human proof-of-concept study. Research design and methods: Pre-clinically, 71 rats were studied in a model of metabolic dysfunction induced by a high-fat diet; 33 animals undergoing one of two lengths of PJD were compared with 18 undergoing sham, 10 RYGB and 10 jejuno-ileal bypass...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29218807/observational-study-on-the-occurrence-of-surgical-glove-perforation-and-associated-risk-factors-in-large-animal-surgery
#15
Nora M Biermann, J T McClure, Javier Sanchez, Aimie J Doyle
OBJECTIVE: To determine the incidence of and associated risk factors for glove perforation in large animal surgery. STUDY DESIGN: Prospective observational cohort study. SAMPLE POPULATION: Surgical gloves (n = 917) worn during 103 large animal surgical procedures. METHODS: Gloves worn by personnel involved in sterile preparation and surgical procedures were tested for perforation by 2 previously validated methods, water leak test (WLT) and electroconductivity testing (ECT)...
December 8, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29210706/clinical-evidence-for-any-effect-of-anesthesia-on-the-developing-brain
#16
Andrew J Davidson, Lena S Sun
A recent U.S. Food and Drug Administration warning advised that prolonged or repeated exposure to general anesthetics may affect neurodevelopment in children. This warning is based on a wealth of preclinical animal studies and relatively few human studies. The human studies include a variety of different populations with several different outcome measures. Interpreting the results requires consideration of the outcome used, the power of the study, the length of exposure and the efforts to reduce the confounding effects of comorbidity and surgery...
November 28, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29207250/a-survey-of-dog-and-cat-anaesthesia-in-a-sample-of-veterinary-practices-in-new-zealand
#17
H Sano, K Barker, T Odom, K Lewis, P Giordano, V Walsh, J P Chambers
AIMS: To survey current anaesthesia practices for dogs and cats in small and mixed animal practices in New Zealand in order to improve anaesthesia education. METHODS: A questionnaire was sent to 440 small and mixed animal practices, including questions regarding the type of practice, preanaesthetic examination, anaesthetic drugs and management, anaesthetic machines, monitoring and topics of interest for continuing professional development. RESULTS: Responses were obtained from 113/440 (26%) practices, with 78 (69%) respondents from small and 35 (31%) from mixed animal practices...
December 5, 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/29206070/efficacy-of-platelet-concentrates-in-bone-healing-a-systematic-review-on-animal-studies-part-b-large-size-animal-models
#18
Sabrina Marcazzan, Silvio Taschieri, Roberto Lodovico Weinstein, Massimo Del Fabbro
In the presence of large bone defects, delayed bone union, or nonunion and fractures, bone reconstruction may be necessary. Different strategies have been employed to enhance bone healing among which the use of autologous platelet concentrates (APCs). Due to the high content of platelets and platelet-derived bioactive molecules (e.g., growth factors, antimicrobial peptides), they are promising candidates to enhance bone healing. However, both preclinical and clinical studies produced contrasting results, mainly due to a high heterogeneity in study design, objectives, techniques adopted, and outcomes assessed...
December 5, 2017: Platelets
https://www.readbyqxmd.com/read/29197607/inflammatory-response-modulation-through-a-ppar%C3%AE-agonist-during-surgically-induced-visceral-ischemia-in-an-animal-model
#19
Bianca Pane, Valerio Gazzola, Giovanni Spinella, Paola Bagnato, Federica Grillo, Valerio Gaetano Vellone, Domenico Palombo
BACKGROUND: Ischemia / reperfusion (I/R) injury represents one of the most severe complications in vascular surgery where cross-clamping of the aorta and subsequent visceral ischemia are a recurrent issue. The literature describes a family of nuclear receptors, i.e., peroxisome-proliferator activated receptors (PPARs), in particular PPARγ isoform, which are important modulators of vascular inflammation resulting from I/R injury. The aim of our study is to evaluate how PPARγ agonist administration could reduce local and systemic inflammatory response after I/R injury during aortic supraceliac clamping in animal model...
November 29, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29157155/work-environment-and-occupational-risk-assessment-for-small-animal-portuguese-veterinary-activities
#20
Angela C Macedo, Vânia T Mota, João M Tavares, Osvaldo L Machado, Francisco X Malcata, Marinela P Cristo, Olga N Mayan
The professional work of small animal veterinary staff encompasses a wide diversity of demanding tasks. This has prompted a number of studies covering physical, chemical, biological, ergonomic or psychological hazards, as well as their health effects upon veterinary workers. However, such results were obtained from self-reported surveys (via paper or online). This study reports the identification of potential hazards and provides a risk assessment of 15 veterinary clinics based on data from walk-through surveys, interviews with workers, and quantification of indoor air quality parameters including concentration of volatile organic compounds (total, isoflurane and glutaraldehyde)...
November 20, 2017: Journal of Occupational and Environmental Hygiene
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