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https://www.readbyqxmd.com/read/22957255/circulating-adiponectin-is-associated-with-renal-function-independent-of-age-and-serum-lipids-in-west-africans
#1
A P Doumatey, J Zhou, H Huang, J Adeleye, W Balogun, O Fasanmade, T Johnson, J Oli, G Okafor, A Amoah, B Eghan, K Agyenim-Boateng, J Acheampong, C Adebamowo, A Adeyemo, C N Rotimi
Adiponectin, a protein secreted by adipose tissue, has been associated with renal dysfunction. However, these observations have not been adequately investigated in large epidemiological studies of healthy individuals in general and in African populations in particular. Hence, we designed this study to evaluate the relationship between adiponectin and renal function in a large group of nondiabetic West Africans. Total adiponectin was measured in 792 participants. MDRD and Cockroft-Gault (CG-) estimated GFR were used as indices of renal function...
2012: International Journal of Nephrology
https://www.readbyqxmd.com/read/19137864/the-prevalence-of-autoimmune-diabetes-among-diabetes-mellitus-patients-in-kumasi-ghana
#2
M T Agyei-Frempong, F V K Titty, W K B A Owiredu, B A Eghan
This study investigate the occurrence and the prevalence of autoantibodies and the metabolic characteristics of autoimmune and antibody-negative type 2, diabetes in recently diagnosed diabetes mellitus patients in Kumasi, Ghana. This study involved a total of 120 recently diagnosed (< 1 year) Ghanaian diabetes mellitus patients (17 insulin-requiring and 103 non insulin-requiring) and 60 controls. A standardized questionnaire was used. Blood pressure and anthropometric measurements were taken. Fasting glucose, lipid and lipoprotein concentrations were measured by enzymatic methods and HbA(1C) levels by agglutination test...
October 1, 2008: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/16130030/agouti-related-protein-promoter-variant-associated-with-leanness-and-decreased-risk-for-diabetes-in-west-africans
#3
C Bonilla, R K Panguluri, L Taliaferro-Smith, G Argyropoulos, G Chen, A A Adeyemo, A Amoah, S Owusu, J Acheampong, K Agyenim-Boateng, B A Eghan, J Oli, G Okafor, F Abbiyesuku, T Johnson, T Rufus, O Fasanmade, Y Chen, F S Collins, G M Dunston, C Rotimi, R A Kittles
OBJECTIVE: The role of the central melanocortin system in the development of obesity has been extensively studied. Single-nucleotide polymorphisms (SNPs) within several candidate genes have been associated with food intake and obesity-related phenotypes; however, few of these associations have been replicated. SNPs in the agouti-related protein (AGRP) gene coding (Ala67Thr, 199G/A) and promoter (-38C/T) have been reported to be associated with body mass index (BMI), fat mass (FM) and percent body fat, in populations of European and African descent...
April 2006: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/15611782/a-genome-wide-scan-for-quantitative-trait-loci-linked-to-obesity-phenotypes-among-west-africans
#4
MULTICENTER STUDY
G Chen, A A Adeyemo, T Johnson, J Zhou, A Amoah, S Owusu, J Acheampong, K Agyenim-Boateng, B A Eghan, J Oli, G Okafor, F Abbiyesuku, G M Dunston, Y Chen, F Collins, C Rotimi
OBJECTIVE: To identify quantitative trait loci (QTL) for three obesity phenotypes: body mass index (BMI), fat mass (FM) and percent body fat (PBF) in West Africans with type 2 diabetes (T2DM). DESIGN: An affected sibling pair (ASP) design, in which both siblings had T2DM. Obesity was analyzed as a quantitative trait using a variance components approach. SUBJECTS: Sib-pairs affected with T2DM from the Africa America Diabetes Mellitus (AADM) study, comprising 321 sibling pairs and 36 half-sibling pairs...
March 2005: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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