keyword
https://read.qxmd.com/read/38510561/efficacy-and-safety-of-pericapsular-nerve-group-block-for-hip-fracture-surgery-under-spinal-anesthesia-a-meta-analysis
#1
JOURNAL ARTICLE
Shukai Li, Jing An, Chengyu Qian, Zhixue Wang
OBJECTIVE: To evaluate the effectiveness and safety of pericapsular nerve group (PENG) block for hip fracture surgery under spinal anesthesia. METHODS: This meta-analysis was registered on INPLASY (INPLASY202270005). PubMed, Embase, Cochrane, CNKI, and Wanfang databases were searched to collect the randomized controlled trials of the PENG block applied to hip fracture surgery in the setting of spinal anesthesia, with the search period from inception to 1 May 2023...
2024: International Journal of Clinical Practice
https://read.qxmd.com/read/38499966/the-continuously-evolving-phenotype-of-succinic-semialdehyde-dehydrogenase-deficiency
#2
JOURNAL ARTICLE
Natalia Alexandra Julia-Palacios, Oya Kuseyri Hübschmann, Mireia Olivella, Roser Pons, Gabriella Horvath, Thomas Lücke, Cheuk-Wing Fung, Suet-Na Wong, Elisenda Cortès-Saladelafont, M Mar Rovira-Remisa, Yılmaz Yıldız, Saadet Mercimek-Andrews, Birgit Assmann, Galina Stevanović, Filippo Manti, Heiko Brennenstuhl, Sabine Jung-Klawitter, Kathrin Jeltsch, H Serap Sivri, Sven F Garbade, Àngels García-Cazorla, Thomas Opladen
The objective of the study is to evaluate the evolving phenotype and genetic spectrum of patients with succinic semialdehyde dehydrogenase deficiency (SSADHD) in long-term follow-up. Longitudinal clinical and biochemical data of 22 pediatric and 9 adult individuals with SSADHD from the patient registry of the International Working Group on Neurotransmitter related Disorders (iNTD) were studied with in silico analyses, pathogenicity scores and molecular modeling of ALDH5A1 variants. Leading initial symptoms, with onset in infancy, were developmental delay and hypotonia...
March 18, 2024: Journal of Inherited Metabolic Disease
https://read.qxmd.com/read/38496261/takotsubo-syndrome-after-bilateral-simultaneous-total-knee-arthroplasty-a-case-report
#3
JOURNAL ARTICLE
Dhanasekaran Soundarrajan, Rithika Singh, Muthiah Subramaniam, Palanisami Dhanasekararaja, Natesan Rajkumar, Shanmuganathan Rajasekaran
INTRODUCTION: Cardiac complications represents a major cause of morbidity and mortality especially after bilateral simultaneous total knee arthroplasty (BS-TKA). Takotsubo syndrome after BS-TKA has not been described in the literature. CASE PRESENTATION: A 60 years-old women underwent BS- TKA and she suddenly developed bradycardia and hypotension after second knee wound closure. The electrocardiography revealed ST elevation and echocardiography showed apical hypokinesia of left ventricle...
August 2024: Journal of Orthopaedics
https://read.qxmd.com/read/38419301/bedside-ultrasound-to-guide-the-diagnosis-and-treatment-of-fulminant-right-heart-failure-a-case-report
#4
JOURNAL ARTICLE
María Camila Arango-Granados, Laura Juliana Osorio-González, Valentina Muñoz-Patiño
BACKGROUND Right ventricular (RV) failure can result from acute or chronic cardiac or pulmonary conditions, or both, resulting in increased afterload, reduced contractility, changes in preload, ventricular interdependence, or dysrhythmias. Notably, increased afterload, particularly among previously healthy individuals, is often the primary cause of RV failure in cases of pulmonary and cardiac origin. Massive pulmonary thromboembolism is a common cause of impending RV failure, and chronic conditions like atrial septal defects can also contribute to pulmonary hypertension...
February 29, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38407742/intra-pericardial-thrombin-injection-in-iatrogenic-cardiac-tamponade-a-case-report
#5
JOURNAL ARTICLE
Juana Perez Morales, Ana Spaccavento, Santiago Ordoñez, Rocío Baro, Diego Conde, Juan Pablo Costabel
BACKGROUND: Nowadays, percutaneous procedures are expanding in use, and this comes with complications associated with the procedure itself. Cardiac tamponade is rare but may be life threatening since it can involve hemodynamic instability. It is known that after pleural effusion during a percutaneous procedure, pericardiocentesis should be used as drainage of the cavity. However, that does not achieve hemostasis in some cases, and in those patients who are hemodynamically unstable, a sealing agent to promote hemostasis might be useful, like thrombin...
February 26, 2024: Egyptian Heart Journal: EHJ
https://read.qxmd.com/read/38399504/physical-activity-and-cognitive-functioning
#6
REVIEW
Francesca Latino, Francesco Tafuri
Neuroscience applied to motor activity is a growing area that aims to understand the effects of motor activity on the structures and functions of the Central Nervous System. Attention has been paid to this multidisciplinary field of investigation by the scientific community both because it is of great importance in the treatment of many chronic diseases and because of its potential applications in the Movement Sciences. Motor activity during a developmental age is, in fact, an indispensable tool for the physical and mental growth of children, both able-bodied and disabled...
January 26, 2024: Medicina
https://read.qxmd.com/read/38367134/the-synergistic-effect-study-of-lipopolysaccharide-lps-and-a53t-%C3%AE-synuclein-intranasal-lps-exposure-on-the-a53t-%C3%AE-synuclein-transgenic-mouse-model-of-parkinson-s-disease
#7
JOURNAL ARTICLE
Qing He, Shuzhen Zhang, Jian Wang, Tengfei Ma, Ding Ma, Li Wu, Mengxi Zhou, Lei Zhao, Yajing Chen, Jianren Liu, Wei Chen
Aging and interactions between genetic and environmental factors are believed to be involved the chronic development of Parkinson's disease (PD). Among PD patients, abnormally aggregated α-synuclein is a major component of the Lewy body. Generally, the intranasal route is believed to be a gate way to the brain, and it assists environmental neurotoxins in entering the brain and is related to anosmia during early PD. The current study applies the chronic intranasal application of lipopolysaccharides (LPS) in 4-, 8-, 12- and 16-month-old A53T-α-synuclein (A53T-α-Syn) transgenic C57BL/6 mice at 2-day intervals for a 2-month period, for evaluating the behavioral, pathological, and biochemical changes and microglial activation in these animals...
February 17, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38337525/the-association-between-intracranial-calcifications-and-symptoms-in-patients-with-primary-familial-brain-calcification
#8
JOURNAL ARTICLE
Gini Mathijssen, Evelien van Valen, Pim A de Jong, Nienke M S Golüke, Emiel A van Maren, Birgitta M G Snijders, Eva H Brilstra, Ynte M Ruigrok, Susan Bakker, Renzo W Goto, Marielle H Emmelot-Vonk, Huiberdina L Koek
(1) Background: Primary Familial Brain Calcification (PFBC) is a neurodegenerative disease characterized by bilateral calcifications of the basal ganglia and other intracranial areas. Many patients experience symptoms of motor dysfunction and cognitive disorders. The aim of this study was to investigate the association between the amount and location of intracranial calcifications with these symptoms. (2) Methods: Patients with suspected PFBC referred to our outpatient clinic underwent a clinical work-up. Intracranial calcifications were visualized on Computed Tomography (CT), and a Total Calcification Score (TCS) was constructed...
January 31, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38295417/case-report-pericardial-actinomycosis-in-a-79-year-old-man-with-poor-dental-hygiene
#9
Chun-Hsun Liao, Tzong-Yow Wu, Yen-Liang Lin, Wang-Da Liu, Jann-Tay Wang, Jin-Shing Chen, Yi-Lwun Ho
Actinomycosis is an uncommon infection caused by Actinomyces species, and the diagnosis is often challenging owing to low prevalence and diverse clinical manifestations. Pericardial involvement of actinomycosis is particularly rare. Here, we present a case of a 79-year-old man who initially complained of exertional dyspnea, orthopnea, and decreased urine amount. There was no fever, chest pain, or productive cough. Physical examination was remarkable for decreased breath sounds at the left lower lung field. Poor dental hygiene and a firm, well-defined mass without discharge over the hard palate were noted...
January 30, 2024: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/38275615/aromatic-l-amino-acid-decarboxylase-deficiency-a-genetic-screening-in-sicilian-patients-with-neurological-disorders
#10
JOURNAL ARTICLE
Sandro Santa Paola, Francesco Domenico Di Blasi, Eugenia Borgione, Mariangela Lo Giudice, Marika Giuliano, Rosa Pettinato, Vincenzo Di Stefano, Filippo Brighina, Antonino Lupica, Carmela Scuderi
Aromatic L-amino acid decarboxylase deficiency (AADCd) is a rare autosomal recessive neurometabolic disorder caused by AADC deficiency, an enzyme encoded by the DDC gene. Since the enzyme is involved in the biosynthesis of serotonin and dopamine, its deficiency determines the lack of these neurotransmitters, but also of norepinephrine and epinephrine. Onset is early and the key signs are hypotonia, movement disorders (oculogyric crises, dystonia and hypokinesia), developmental delay and autonomic dysfunction...
January 21, 2024: Genes
https://read.qxmd.com/read/38270617/cardiac-toxicity-of-brentuximab-vedotin-a-real-word-disproportionality-analysis-of-the-fda-adverse-event-reporting-system-faers-database
#11
JOURNAL ARTICLE
Chengjie Ke, Maohua Chen, Yaping Huang, Yan Chen, Cuihong Lin, Pinfang Huang
Brentuximab vedotin (BV) has obtained approval for the therapeutic management of classical Hodgkin lymphoma as well as systemic anaplastic large cell lymphoma. Given the inherent constraints of conventional clinical trials, the correlation between BV and cardiac adverse events (AEs) remains enigmatic. The objective of this investigation is to comprehensively assess cardiac AEs attributed to BV by employing advanced data mining techniques, utilizing the FDA Adverse Event Reporting System (FAERS). The indices for the assessment of disproportionality encompass the reporting odds ratio (ROR), the proportional reporting ratio, the information component, and the empirical Bayesian geometric mean...
January 25, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38255008/sodium-channel-gene-variants-in-fetuses-with-abnormal-sonographic-findings-expanding-the-prenatal-phenotypic-spectrum-of-sodium-channelopathies
#12
JOURNAL ARTICLE
Andrea Hadjipanteli, Athina Theodosiou, Ioannis Papaevripidou, Paola Evangelidou, Angelos Alexandrou, Nicole Salameh, Ioannis Kallikas, Kyriakos Kakoullis, Sofia Frakala, Christina Oxinou, Andreas Marnerides, Ludmila Kousoulidou, Violetta C Anastasiadou, Carolina Sismani
Voltage-gated sodium channels (VGSCs) are responsible for the initiation and propagation of action potentials in the brain and muscle. Pathogenic variants in genes encoding VGSCs have been associated with severe disorders including epileptic encephalopathies and congenital myopathies. In this study, we identified pathogenic variants in genes encoding the α subunit of VGSCs in the fetuses of two unrelated families with the use of trio-based whole exome sequencing, as part of a larger cohort study. Sanger sequencing was performed for variant confirmation as well as parental phasing...
January 18, 2024: Genes
https://read.qxmd.com/read/38249237/clinically-suspected-acute-myocarditis-in-the-first-trimester-of-twin-gestation-a-case-report
#13
Herson S Flores-Sanga, Dafne Salas-Cuadros, Jose Luis Saucedo-Chinchay, Jose Arriola-Montenegro, Javier Torres-Valencia, Juan Manuel Muñoz-Moreno
Acute myocarditis (AM) in early pregnancy is a rare disease. Its clinical presentation varies from asymptomatic disease to cardiogenic shock and death. A 28-year-old woman, 12 weeks primigravida of a dichorionic and diamniotic pregnancy, was admitted for hyperemesis gravidarum, associated with a common cold-like condition. During hospitalization, she developed new-onset sinus tachycardia and dyspnea. An electrocardiogram revealed sinus tachycardia and diffuse ST-segment elevation. Laboratory tests showed elevated levels of troponin and pro-B-type natriuretic peptide...
December 2023: Curēus
https://read.qxmd.com/read/38189872/features-of-%C3%AE-2-adrenergic-regulation-of-isolated-rat-heart-after-hypokinesia
#14
JOURNAL ARTICLE
M I Sungatullina, R I Zaripova, L T Mosolov, A M Sadykov, N I Ziyatdinova, T L Zefirov
We studied the effect of the α2 -adrenergic receptor agonist clonidine hydrochloride (10-9 -10-6 M) on the isolated heart of adult rats after 30-day restriction of motor activity. In hypokinetic rats, in comparison with control animals, clonidine caused a positive inotropic effect; the dynamics of coronary flow was changed after stimulation of α2 -adrenergic receptors by clonidine in the minimum and maximum concentrations. Moreover, clonidine in concentrations of 10-8 and 10-7 M reduced coronary flow both in the control group and against the background of hypokinesia...
January 8, 2024: Bulletin of Experimental Biology and Medicine
https://read.qxmd.com/read/38186413/hemochromatosis-in-an-adult-female-with-previous-iron-deficiency-anemia-on-iron-supplementation
#15
Keval Yerigeri
A 56-year-old female presented with a diagnosis of iron deficiency anemia over three years prior (on oral iron supplementation) and presented with altered mental status. She was admitted to the Coronary Care Unit for troponinemia and T-wave inversions. Two-dimensional echocardiography revealed hypokinesia of the left ventricle (LV) anterior wall with reduced ejection fraction. The patient was stabilized on metoprolol and heparin infusions, but heparin was discontinued after iron studies revealed overload (iron: 159 ug/dL, 100% saturation, ferritin: 1480 ng/mL)...
December 2023: Curēus
https://read.qxmd.com/read/38180703/indicators-of-lpo-and-antioxidant-protection-in-rats-during-long-term-restriction-of-motor-activity
#16
JOURNAL ARTICLE
A V Elikov
This article presents a comprehensive study of the parameters of LPO (concentrations of malondialdehyde, diene conjugates, and intensity of chemiluminescence) and antioxidant defense (concentrations of α-tocopherol, ceruloplasmin, total antioxidant activity, antiradical activity, and activities of antioxidant enzymes - superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) in blood plasma and erythrocytes of white male rats during restriction of motor activity up to 28 days...
December 2023: Bulletin of Experimental Biology and Medicine
https://read.qxmd.com/read/38152526/subthalamic-deep-brain-stimulation-in-parkinson-s-disease-a-boon-or-bane-a-single-centre-retrospective-observational-study-from-india
#17
JOURNAL ARTICLE
Darpanarayan Hazra, Gina Maryann Chandy, Amit Ghosh
Background  Subthalamic deep brain stimulation (STN-DBS) for refractory Parkinson's disease (PD) is more of a modality of treatment that is empirical, for which a physiological explanation is being sought. This study was done to determine the outcome and complications of patients undergoing STN-DBS for PD. Methods  This retrospective observational cohort study was conducted in an advanced neuromedicine facility in eastern India for 9 years (August 2013-August 2022), which included all patients undergoing STN-DBS...
September 2023: Asian Journal of Neurosurgery
https://read.qxmd.com/read/38130561/ventricular-tachycardia-as-a-presentation-of-isolated-cardiac-sarcoidosis-how-to-manage-it-when-we-do-not-see-granulomas
#18
Luis René Puglla Sánchez, Begoña De Escalante Yangüela, Javier Escota-Villanueva, Juan Vallejo Grijalba, Darío J Samaniego Pesántez
A 47-year-old male was referred for rapid palpitations and an electrocardiogram compatible with sustained monomorphic ventricular tachycardia (VT) that required synchronized electrical cardioversion due to hemodynamic instability. After the initial clinical certainty, an etiological search is carried out. The transthoracic echocardiogram (TTE) revealed moderate dilatation and left ventricular systolic dysfunction due to global hypokinesia. Coronary angiography did not show significant coronary stenosis. Cardiac magnetic resonance (CMR) guarantees a nonischemic dilated cardiomyopathy with moderate systolic dysfunction and a pattern of subepicardial and intramyocardial late gadolinium enhancement (LGE) in medial-lateral and median inferolateral segments...
November 2023: Curēus
https://read.qxmd.com/read/38114633/a-three-dimensional-model-of-neural-activity-and-phenomenal-behavioral-patterns
#19
REVIEW
Matteo Martino, Paola Magioncalda
How phenomenal experience and behavior are related to neural activity in physiology and psychopathology represents a fundamental question in neuroscience and psychiatry. The phenomenal-behavior patterns may be deconstructed into basic dimensions, i.e., psychomotricity, affectivity, and thought, which might have distinct neural correlates. This work provides a data overview on the relationship of these phenomenal-behavioral dimensions with brain activity across physiological and pathological conditions (including major depressive disorder, bipolar disorder, schizophrenia, attention-deficit/hyperactivity disorder, anxiety disorders, addictive disorders, Parkinson's disease, Tourette syndrome, Alzheimer's disease, and frontotemporal dementia)...
December 19, 2023: Molecular Psychiatry
https://read.qxmd.com/read/38099220/influence-of-electrolyte-imbalance-on-regional-wall-motion-abnormalities-in-stemi-patients-of-north-indian-origin
#20
JOURNAL ARTICLE
S Mohd Shiraz Rizvi, Sini Sunny, Irshad A Wani, Farzana Mahdi, Zeeshan H Zaidi, Namakkal S Rajasekaran
Assessing regional wall motion abnormalities (RWMA) in the myocardium may provide early diagnosis and treat chronic remodeling in STEMI patients. We assessed RWMA in 217 subjects with anterior STEMI admitted to Era University Hospital in Lucknow, UP, India. Besides abnormalities in the LAD territory, sub-sets of patients exhibited diffuse regional myocardial dysfunction. Interestingly, variations in serum electrolytes, specifically sodium and potassium, significantly affected the distribution and frequency of RWMA...
2023: Frontiers in Cardiovascular Medicine
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