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Oxytocin dosing

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https://www.readbyqxmd.com/read/28649672/oxytocin-and-stress-related-disorders-neurobiological-mechanisms-and-treatment-opportunities
#1
Lauren M Sippel, Casey E Allington, Robert H Pietrzak, Ilan Harpaz-Rotem, Linda C Mayes, Miranda Olff
Novel pharmacotherapies that improve outcomes for individuals with stress-related psychiatric disorders are needed. The neurohormone oxytocin (OT) is a promising candidate given its influence on the social-emotional brain. In this review, we present an overview of evidence supporting OT's utility for treating major depressive disorder and posttraumatic stress disorder. We first discuss endogenous OT, which research suggests is not yet a reliable biomarker of stress-related disorders. Second, we review effects of intranasal (IN) OT on processes relevant to stress-related disorders in healthy populations (anhedonia, reward processing, psychosocial stress reactivity, fear/anxiety, and social behavior) and their neurobiological mechanisms (e...
February 2017: Chronic stress
https://www.readbyqxmd.com/read/28629540/kinetics-and-dose-dependency-of-intranasal-oxytocin-effects-on-amygdala-reactivity
#2
Franny B Spengler, Johannes Schultz, Dirk Scheele, Maximiliane Essel, Wolfgang Maier, Markus Heinrichs, René Hurlemann
BACKGROUND: Current neuroimaging perspectives on a variety of mental disorders emphasize dysfunction of the amygdala. The neuropeptide oxytocin (OXT), a key mediator in the regulation of social cognition and behavior, accumulates in cerebrospinal fluid after intranasal administration in macaques and humans and modulates amygdala reactivity in both species. However, the translation of neuromodulatory OXT effects to novel treatment approaches is hampered by the absence of studies defining the most effective dose and dose-response latency for targeting the amygdala...
May 10, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28624988/mifepristone-vs-balloon-catheter-for-labor-induction-in-previous-cesarean-a-randomized-controlled-trial
#3
Chanderdeep Sharma, Anjali Soni, Amit Gupta, Ashok Verma, Suresh Verma
OBJECTIVE: To compare oral mifepristone (400 mg) with trans-cervical balloon catheter for induction of labor (IOL) in post date women with previous one cesarean section (CS). METHODS: In this randomized trial, post date pregnant women (gestation 40 weeks 5 days), with previous one low segment CS (no previous vaginal delivery) were induced either with oral mifepristone (400 mg) or balloon catheter [Foley's catheter (16 Fr); bulb filled with 30 ml normal saline]...
June 17, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28623008/yucca-schidigera-can-promote-rabbit-growth-fecundity-affect-the-release-of-hormones-in-vivo-and-in-vitro-induce-pathological-changes-in-liver-and-reduce-ovarian-resistance-to-benzene
#4
Martina Földešiová, Andrej Baláži, Ľubica Chrastinová, Juraj Pivko, Jan Kotwica, Abdel Halim Harrath, Peter Chrenek, Alexander V Sirotkin
This study evaluated the effect of Yucca schidigera (YS) extract on the physiological, reproductive, and endocrine indexes of New Zealand White rabbit does. Six-week-old rabbit does were fed a standard diet (control group) or a diet enriched with 5 or 20g of Y powder extract per 100-kg feed mixture for 350days. The does were artificially inseminated after induction of superovulation. Weight gain; conception and kindling rate; viability of pups and mothers; histopathological state of liver and muscle; plasma levels of progesterone (P4), oxytocin (OT), and prostaglandin F (PGF); and the release of P4, insulin-like growth factor I (IGF-I), OT, and PGF by isolated ovarian fragments and their response to the addition of benzene were analyzed...
June 10, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28590943/suppressed-play-behaviour-and-decreased-oxytocin-receptor-binding-in-the-amygdala-after-prenatal-exposure-to-low-dose-valproic-acid
#5
Freja Bertelsen, Davide Folloni, Arne Møller, Anne M Landau, Jørgen Scheel-Krüger, Michael Winterdahl
To better understand the role of the neuropeptide oxytocin in autism spectrum disorder (ASD), we investigated potential deficits in social play behaviour and oxytocin receptor (OXTR) density alterations in the amygdala in a rodent model of ASD. Pregnant rats were injected daily with 20 or 100 mg/kg valproic acid (VPA) or saline from day 12 until the end of pregnancy. The number of pinning and pouncing events was assessed at postnatal days 29-34. Brains from male offspring (n=7/group) were removed at postnatal day 50...
June 6, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28590768/effect-of-hydroalcoholic-extract-of-capsella-bursa-pastoris-on-early-postpartum-hemorrhage-a-clinical-trial-study
#6
Sahar Ghalandari, Nourossadat Kariman, Zohre Sheikhan, Faraz Mojab, Moghadameh Mirzaei, Hadis Shahrahmani
OBJECTIVES: Postpartum hemorrhage (PPH) is one of three main causes of maternal mortality and a life-threatening condition throughout the world. PPH can have irreversible complications for the mother even if it does not lead to death. This study was conducted to determine the effect of hydroalcoholic extract of Capsella bursa pastoris on early PPH. DESIGN: The present study was a single-blinded, randomized, clinical trial. SETTING: The study was conducted in Afzalipour Hospital of Kerman in 2015...
June 7, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28587936/intra-hippocampal-microinjection-of-oxytocin-produced-antiepileptic-effect-on-the-pentylenetetrazol-induced-epilepsy-in-rats
#7
Amir Erfanparast, Esmaeal Tamaddonfard, Farzin Henareh-Chareh
BACKGROUND: In addition to its role as a circulating hormone, oxytocin can also act as a neurotransmitter and a neuromodulator within the brain. In this study, we investigated the intra-hippocampal effect of oxytocin on an experimental seizure model induced by pentylenetetrazole (PTZ) in rats. We also used atosiban (oxytocin antagonist), diazepam and flumazenil (gamma-aminobutyric acid or GABA-benzodiazepine receptor agonist and antagonist, respectively) to clarify the involved mechanism...
March 12, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28551755/the-role-of-the-oxytocin-arginine-vasopressin-system-in-animal-models-of-autism-spectrum-disorder
#8
Rong Zhang, Xin-Jie Xu, Hong-Feng Zhang, Song-Ping Han, Ji-Sheng Han
The nonapeptides oxytocin (OXT) and arginine vasopressin (AVP) are two key mediators in regulating various aspects of mammalian social behaviours. There are several lines of evidence that genetic variants of the OXT/AVP system exist in autism spectrum disorder (ASD) and that this system is dysfunctional at least in some ASD entities. These findings have stimulated the interest to perform studies testing the potential therapeutic application of OXT/AVP in ASD. In this respect animal models are critical for investigating the pathophysiology and for compound screening leading to new therapeutic approaches...
2017: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/28551715/direct-comparison-of-the-acute-subjective-emotional-autonomic-and-endocrine-effects-of-mdma-methylphenidate-and-modafinil-in-healthy-subjects
#9
Patrick C Dolder, Felix Müller, Yasmin Schmid, Stefan J Borgwardt, Matthias E Liechti
RATIONALE: 3,4-Methylenedioxymethamphetamine (MDMA) is used recreationally and investigated as an adjunct to psychotherapy. Methylphenidate and modafinil are psychostimulants that are used to treat attention-deficit/hyperactivity disorder and narcolepsy, respectively, but they are also misused as cognitive enhancers. Little is known about differences in the acute effects of equally cardiostimulant doses of these stimulant-type substances compared directly within the same subjects. METHODS: We investigated the acute autonomic, subjective, endocrine, and emotional effects of single doses of MDMA (125 mg), methylphenidate (60 mg), modafinil (600 mg), and placebo in a double-blind, cross-over study in 24 healthy participants...
May 27, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28539519/positive-social-behaviours-are-induced-and-retained-after-oxytocin-manipulations-mimicking-endogenous-concentrations-in-a-wild-mammal
#10
Kelly J Robinson, Sean D Twiss, Neil Hazon, Simon Moss, Patrick P Pomeroy
The neuropeptide hormone oxytocin modulates numerous social and parental behaviours across a wide range of species, including humans. We conducted manipulation experiments on wild grey seals (Halichoerus grypus) to determine whether oxytocin increases proximity-seeking behaviour, which has previously been correlated with endogenous oxytocin concentrations in wild seal populations. Pairs of seals that had never met previously were given intravenous injections of 0.41 µg kg(-1) oxytocin or saline and were observed for 1 h post-manipulation...
May 31, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28534875/dose-dependent-social-cognitive-effects-of-intranasal-oxytocin-delivered-with-novel-breath-powered-device-in-adults-with-autism-spectrum-disorder-a-randomized-placebo-controlled-double-blind-crossover-trial
#11
D S Quintana, L T Westlye, S Hope, T Nærland, T Elvsåshagen, E Dørum, Ø Rustan, M Valstad, L Rezvaya, H Lishaugen, E Stensønes, S Yaqub, K T Smerud, R A Mahmoud, P G Djupesland, O A Andreassen
The neuropeptide oxytocin has shown promise as a treatment for symptoms of autism spectrum disorders (ASD). However, clinical research progress has been hampered by a poor understanding of oxytocin's dose-response and sub-optimal intranasal delivery methods. We examined two doses of oxytocin delivered using a novel Breath Powered intranasal delivery device designed to improve direct nose-to-brain activity in a double-blind, crossover, randomized, placebo-controlled trial. In a randomized sequence of single-dose sessions, 17 male adults with ASD received 8 international units (IU) oxytocin, 24IU oxytocin or placebo followed by four social-cognitive tasks...
May 23, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28534100/dose-dependent-differential-effects-of-in-vivo-exposure-of-cadmium-on-myometrial-activity-in-rats-involvement-of-vdcc-and-ca-2-mimicking-pathways
#12
Vivek K Saroj, Udayraj P Nakade, Abhishek Sharma, Soumen Choudhury, Sunil W Hajare, Satish K Garg
Present study was undertaken to study the effect of 28-days exposure of female adult rats to cadmium (Cd) in drinking water @ 3, 10 and 30 parts per million (ppm) on myometrial responsiveness to different spasmogens and unravel the possible mechanism of alterations in myometrial activity. Cadmium and Ca(2+) levels in blood and uterus were measured by atomic absorption spectroscopy while isometric tension in myometrial strips was measured using data acquisition system-based physiograph. Dose-dependent increase in levels of cadmium was observed in both blood and uterus while calcium was increased only in the uterus as compared to those in control...
May 22, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28532683/the-essential-oil-from-the-twigs-of-cinnamomum-cassia-presl-inhibits-oxytocin-induced-uterine-contraction-in-vitro-and-in-vivo
#13
Lan Sun, Li-Na Liu, Jia-Chun Li, Yao-Zhong Lv, Shao-Bo Zong, Jun Zhou, Zheng-Zhong Wang, Jun-Ping Kou, Wei Xiao
ETHNOPHARMACOLOGICAL RELEVANCE: The twigs and bark of Cinnamomum cassia Presl (Lauraceae) are widely used in traditional Chinese medicine in the treatment of tumor, abdominal pain, dysmenorrhea, digestive system disease and inflammatory diseases. The aim of this study was to determine the inhibitory effect of the essential oil from the twigs of Cinnamomum cassia Presl (EOCC) on uterine contraction in vitro and in vivo. MATERIALS AND METHODS: The Institute of Cancer Research (ICR) mouse uterine contraction was induced by oxytocin (OT) exposure following estradiol benzoate pretreatment...
May 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28532287/maternal-body-mass-index-and-oxytocin-exposure-in-nulliparous-women-is-there-an-interaction-associated-with-maternal-and-neonatal-morbidities
#14
Akila Subramaniam, John Owen, Sukhkamal B Campbell, Lorie M Harper, Joseph L Fitzwater, Rodney K Edwards
OBJECTIVE: Increasing body mass index (BMI) and administered doses of oxytocin are related to maternal and neonatal morbidities. We evaluated the effect of oxytocin dosage, BMI, and their interaction on select perinatal outcomes. STUDY DESIGN: We retrospectively studied nulliparas with singletons ≥36 weeks' gestation who received oxytocin and reached the second stage of labor. Oxytocin dosage was defined by the oxytocin product ([maximum oxytocin dose] × [duration of oxytocin infusion]/100 (milliunits))...
June 6, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28526519/oxytocin-administration-during-spontaneous-labor-guidelines-for-clinical-practice-chapter-4-oxytocin-efficiency-according-to-implementation-in-insufficient-spontaneous-labor
#15
B Coulm, V Tessier
No abstract text is available yet for this article.
May 16, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28526450/the-association-of-single-nucleotide-polymorphisms-in-the%C3%A2-oxytocin-receptor-and-g-protein-coupled-receptor-kinase-6-grk6-genes-with-oxytocin-dosing-requirements-and-labor-outcomes
#16
Chad A Grotegut, Emily Ngan, Melanie E Garrett, Marie Lynn Miranda, Allison E Ashley-Koch, Geeta K Swamy
BACKGROUND: Oxytocin is a potent uterotonic agent that is widely used for induction and augmentation of labor. Oxytocin has a narrow therapeutic index and the optimal dosing for any individual woman varies widely. OBJECTIVE: The objective of this study was to determine whether genetic variation in the oxytocin receptor (OXTR) or in the gene encoding G protein-coupled receptor kinase 6 (GRK6), which regulates desensitization of the oxytocin receptor, could explain variation in oxytocin dosing and labor outcomes among women being induced near term...
May 17, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28512038/involvement-of-the-oxytocin-system-in-the-nucleus-accumbens-in-the-regulation-of-juvenile-social-novelty-seeking-behavior
#17
Caroline J W Smith, Jazmin N Mogavero, Maxwell T Tulimieri, Alexa H Veenema
Exploration of novel environments, stimuli, and conspecifics is highly adaptive during the juvenile period, as individuals transition from immaturity to adulthood. We recently showed that juvenile rats prefer to interact with a novel individual over a familiar cage mate. However, the neural mechanisms underlying this juvenile social novelty-seeking behavior remain largely unknown. One potential candidate is the oxytocin (OXT) system, given its involvement in various motivated social behaviors. Here, we show that administration of the specific oxytocin receptor antagonist desGly-NH2,d(CH2)5-[Tyr(Me)(2),Thr(4)]OVT reduces social novelty seeking-behavior in juvenile male rats when injected into the nucleus accumbens (10ng/0...
May 20, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28485846/oxytocin-and-migraine-headache
#18
REVIEW
Alexander Tzabazis, Shashi Kori, Jordan Mechanic, James Miller, Conrado Pascual, Neil Manering, Dean Carson, Michael Klukinov, Egilius Spierings, Daniel Jacobs, Jason Cuellar, William H Frey, Leah Hanson, Martin Angst, David C Yeomans
This article reviews material presented at the 2016 Scottsdale Headache Symposium. This presentation provided scientific results and rationale for the use of intranasal oxytocin for the treatment of migraine headache. Results from preclinical experiments are reviewed, including in vitro experiments demonstrating that trigeminal ganglia neurons possess oxytocin receptors and are inhibited by oxytocin. Furthermore, most of these same neurons contain CGRP, the release of which is inhibited by oxytocin. Results are also presented which demonstrate that nasal oxytocin inhibits responses of trigeminal nucleus caudalis neurons to noxious stimulation using either noxious facial shock or nitroglycerin infusion...
May 2017: Headache
https://www.readbyqxmd.com/read/28479288/a-randomized-trial-of-foley-bulb-for-labor-induction-in%C3%A2-premature-rupture-of-membranes-in-nulliparas-flip
#19
Jennifer M H Amorosa, Joanne Stone, Stephanie H Factor, Whitney Booker, Meredith Newland, Angela Bianco
BACKGROUND: In premature rupture of membranes (PROM), the risk of chorioamnionitis increases with increasing duration of membrane rupture. Decreasing the time from PROM to delivery is associated with lower rates of maternal infection. The American College of Obstetricians and Gynecologists suggests that all women with PROM who do not have a contraindication to vaginal delivery have their labor induced instead of being managed expectantly. Although the use of oxytocin for labor induction has been demonstrated to decrease the time to delivery compared with expectant management, no studies have evaluated the effectiveness of cervical ripening with a Foley bulb to additionally decrease the time to delivery...
May 4, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28476692/oxytocin-administration-during-spontaneous-labor-guidelines-for-clinical-practice-chapter-7-epidural-analgesia-and-use-of-oxytocin-during-spontaneous-labor
#20
C Fischer
No abstract text is available yet for this article.
May 2, 2017: Journal of gynecology obstetrics and human reproduction
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