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Oxytocin dosing

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https://www.readbyqxmd.com/read/28797187/a-survey-of-physicians-attitudes-toward-uterotonic-administration-in-parturients-undergoing-cesarean-section
#1
Sharon Orbach-Zinger, Sharon Einav, Assaf Yonah, Leonid A Eidelman, Shia Fein, Atara Davis Ba, Alexander Ioscovich
OBJECTIVE: Oxytocin is globally accepted as first line treatment for prevention of post partum hemorrhage. However there is wide variability in its use in clinical practice. In this study we aimed to evaluate obstetricians and anesthesiologists attitudes towards uterotonic practices in Israel. STUDY DESIGN: The current survey was designed to study the preferences of obstetricians and anesthesiologists in seven University hospitals regarding the type, dose and mode of administration of uterotonic drugs, as well as their knowledge regarding the side effects of these drugs...
August 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28781129/safety-tolerability-and-pharmacokinetics-of-single-doses-of-oxytocin-administered-via-an-inhaled-route-in-healthy-females-randomized-single-blind-phase-1-study
#2
Disala Fernando, Sarah Siederer, Sunita Singh, Ian Schneider, Ashutosh Gupta, Marcy Powell, Duncan Richards, Michelle P McIntosh, Peter Lambert, Susan Fowles
BACKGROUND: The utility of intramuscular (IM) oxytocin for the prevention of postpartum hemorrhage in resource-poor settings is limited by the requirement for temperature-controlled storage and skilled staff to administer the injection. We evaluated the safety, tolerability and pharmacokinetics (PK) of a heat-stable, inhaled (IH) oxytocin formulation. METHODS: This phase 1, randomized, single-center, single-blind, dose-escalation, fixed-sequence study (NCT02542813) was conducted in healthy, premenopausal, non-pregnant, non-lactating women aged 18-45years...
August 2017: EBioMedicine
https://www.readbyqxmd.com/read/28770970/oxtr-and-zeb1-expression-before-and-after-progesterone-dosing-in-pregnant-women-with-threatened-premature-labor
#3
Y-J Xu, L-D Ren, S-S Zhai, L-M Ran, L-L Hu, X-H Luo, T Hong, R Liu, Y-R Yu, Y-J Ban
OBJECTIVE: To investigate changes in the peripheral blood mRNA levels of oxytocin receptor (OXTR) and Zinc finger E-box-binding homeobox 1 (ZEB1) before and after progesterone dosing in pregnant women with threatened premature labor. PATIENTS AND METHODS: Blood samples were collected from 30 healthy pregnant women with 28- to 33+6-week gestational age and singleton pregnancy (group A) and from 30 pregnant women with singleton pregnancy and threatened premature labor before and 48 hours after progesterone dosing (groups B and C, respectively) for quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) assay to assess the OXTR and ZEB1 mRNA levels...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28766270/oxytocin-and-autism-spectrum-disorders
#4
Hidenori Yamasue, Gregor Domes
Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose core symptoms include deficits in social interaction and communication besides restricted and repetitive behaviors. Although ASD is highly prevalent, affecting 1/100 in the general population, no medication for the core symptoms has been established. Therefore, the disorder is considered a huge unmet medical need and a heavy burden on individuals with ASD, their families, and entire society. Oxytocin is expected to be a potential therapeutic resource for the social core symptoms of ASD, since this neuropeptide can modulate human social behavior and cognition...
August 2, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28765081/intranasal-oxytocin-and-a-polymorphism-in-the-oxytocin-receptor-gene-are-associated-with-human-directed-social-behavior-in-golden-retriever-dogs
#5
Mia E Persson, Agaia J Trottier, Johan Bélteky, Lina S V Roth, Per Jensen
The oxytocin system may play an important role in dog domestication from the wolf. Dogs have evolved unique human analogue social skills enabling them to communicate and cooperate efficiently with people. Genomic differences in the region surrounding the oxytocin receptor (OXTR) gene have previously been associated with variation in dogs' communicative skills. Here we have utilized the unsolvable problem paradigm to investigate the effects of oxytocin and OXTR polymorphisms on human-directed contact seeking behavior in 60 golden retriever dogs...
July 29, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28764883/involvement-of-gabaa-receptors-in-the-regulation-of-social-preference-and-emotional-behaviors-by-oxytocin-in-the-central-amygdala-of-female-mandarin-voles
#6
Na Dong, Peirong Du, Xin Hao, Zhixiong He, Wenjuan Hou, Limin Wang, Wei Yuan, Jinfeng Yang, Rui Jia, Fadao Tai
The central nucleus of the amygdala (CeA) is the main output of the amygdala and plays an important role in behavioral and neuroendocrine responses to stress. Receptors for the neuropeptide oxytocin (OT) and GABAA are found in high concentration in the CeA. The mechanisms underlying regulation of CeA OT in emotional and social behavior remain unclear. In this study we evaluated the effects of intra-CeA OT administration of different doses (0.1, 1 and 10ng/side), OT receptor antagonist (OTR-A) (1, 10 and 100ng/side) and OT plus OTR-A on social and emotional behavior using a social preference paradigm, open field test and elevated plus maze test in female monogamous mandarin voles (Microtus mandarinus)...
July 25, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28721467/a-review-of-the-safety-efficacy-and-mechanisms-of-delivery-of-nasal-oxytocin-in-children-therapeutic-potential-for-autism-and-prader-willi-syndrome-and-recommendations-for-future-research
#7
Marilena M DeMayo, Yun Ju C Song, Ian B Hickie, Adam J Guastella
In this article, we conduct a comprehensive review of existing evidence for the safety and therapeutic potential of intranasal oxytocin in pediatric populations. Unique considerations for dosing and delivery of oxytocin to the nasal passageway in pediatric populations and methods to promote adherence are reviewed. Intranasal oxytocin has been administered to 261 children in three open-label studies and eight randomized controlled trials. To date, the only published results in pediatric populations have focused on autism spectrum disorder (ASD) and Prader-Willi syndrome (PWS)...
July 18, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28707488/efficacy-of-oxytocin-versus-carbetocin-in-prevention-of-postpartum-hemorrhage-after-cesarean-section-under-general-anesthesia-a-prospective-randomized-clinical-trial
#8
Robabeh Taheripanah, Amal Shoman, Mohammad Ali Karimzadeh, Marzieh Zamaniyan, Narges Malih
OBJECTIVE: To compare the use of carbetocin and oxytocin in the prevention of postpartum hemorrhage after cesarean section. METHODS: The present study was a prospective double-blind randomized controlled clinical trial performed in two university-based hospitals in Tehran, Iran. Two hundred and twenty women with the gestational age of more than 37 weeks, who needed cesarean operation, participated in the study. Patients were assigned to receive either a single 100 μg IV dose of carbetocin or a standard 30-international unit IV infusion of oxytocin during 2 h after delivery of placenta...
July 25, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28697540/three-doses-of-oral-misoprostol-versus-an-intra-cervical-foley-catheter-for-24-hours-for-pre-induction-cervical-ripening-in-post-dated-pregnancies-a-randomized-controlled-trial
#9
D Somirathne, Malik Goonewardene, L Dahanayake
Objectives: To compare three doses of oral misoprostol 50μg four hourly versus an intra-cervical Foley catheter for 24 hours, for pre-induction cervical ripening. Methods: Primary investigator blinded, randomised controlled trial conducted in 180 consecutive women with singleton uncomplicated pregnancies with Modified Bishop Score (MBS) 5 at 40 weeks + 6 days gestation, allocated by stratified (primigravida / multigravida) block randomization to receive three doses of oral misoprostol 50μg four hourly or an intra-cervical Foley catheter for 24 hours...
June 30, 2017: Ceylon Medical Journal
https://www.readbyqxmd.com/read/28695319/acute-impact-of-selected-pyridoindole-derivatives-on-fos-expression-in-different-structures-of-the-rat-brain
#10
Romana Koprdova, Jana Osacka, Mojmir Mach, Alexander Kiss
The impacts of three pyridoindole derivatives (PDs), designated as PD144, PD143, and PD104, which have previously been shown to have antidepressant (PD144) and anxiolytic (PD143, PD104) properties, were investigated on the Fos expressions in 11 different rat brain areas, including the medial prefrontal cortex, striatum, septum, accumbens nucleus (shell, core), bed nucleus of the stria terminalis, hypothalamic paraventricular nucleus, central amygdala, locus coeruleus, dorsal raphe nucleus, and the solitary tract nucleus...
July 10, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28681933/effect-of-low-level-laser-therapy-and-oxytocin-on-osteoporotic-bone-marrow-derived-mesenchymal-stem-cells
#11
Somaye Fallahnezhad, Abbas Piryaie, Hasan Darbandi, Abdollah Amini, Seyed Kamran Ghorishi, Reza Jalalifirouzkouhi, Mohammad Bayat
Postmenopausal osteoporosis (OP) is a major concern for public health. Low-level laser therapy (LLLT) has a positive effect on the health of bone marrow mesenchymal stem cells (BMMSCs). The purpose of this study is to evaluate the influence of LLLT and oxytocin (OT) incubation-individually and in combination-on osteoporotic BMMSCs in ovariectomized rats. Twelve female rats were randomized into two groups to undergo either a sham surgery (sham group) or ovariectomy-induced osteoporosis OP (OVX group). MSCs harvested from the BM of healthy and OVX rats underwent culture expansion...
July 6, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28668289/foley-catheterisation-versus-oral-misoprostol-for-induction-of-labour-in-hypertensive-women-in-india-inform-a-multicentre-open-label-randomised-controlled-trial
#12
Shuchita Mundle, Hillary Bracken, Vaishali Khedikar, Jayashree Mulik, Brian Faragher, Thomas Easterling, Simon Leigh, Paul Granby, Alan Haycox, Mark A Turner, Zarko Alfirevic, Beverly Winikoff, Andrew D Weeks
BACKGROUND: Between 62 000 and 77 000 women die annually from pre-eclampsia and eclampsia. Prompt delivery, preferably by the vaginal route, is vital for good maternal and neonatal outcomes. Two low-cost interventions-low-dose oral misoprostol tablets and transcervical Foley catheterisation-are already used in low-resource settings. We aimed to compare the relative risks and benefits of these interventions. METHODS: We undertook this multicentre, open-label, randomised controlled trial in two public hospitals in Nagpur, India...
June 28, 2017: Lancet
https://www.readbyqxmd.com/read/28664358/oxytocin-intranasal-administration-affects-neural-networks-upstream-of-gnrh-neurons
#13
Mohammad Saied Salehi, Homayoun Khazali, Fariba Mahmoudi, Mahyar Janahmadi
The last decade has witnessed a surge in studies on the clinical applications of intranasal oxytocin as a method of enhancing social interaction. However, the molecular and cellular mechanisms underlying its function are not completely understood. Since oxytocin is involved in the regulation of hypothalamic-pituitary-gonadal axis by affecting the gonadotropin-releasing hormone (GNRH) system, the present study addressed whether intranasal application of oxytocin has a role in affecting GNRH expression in the male rat hypothalamus...
August 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28655900/oxytocin-administration-suppresses-hypothalamic-activation-in-response-to-visual-food-cues
#14
Agatha A van der Klaauw, Hisham Ziauddeen, Julia M Keogh, Elana Henning, Sekesai Dachi, Paul C Fletcher, I Sadaf Farooqi
The aim of this study was to use functional neuroimaging to investigate whether oxytocin modulates the neural response to visual food cues in brain regions involved in the control of food intake. Twenty-four normal weight volunteers received intranasal oxytocin (24 IU) or placebo in a double-blind, randomized crossover study. Measurements were made forty-five minutes after dosing. On two occasions, functional MRI (fMRI) scans were performed in the fasted state; the blood oxygen level-dependent (BOLD) response to images of high-calorie foods versus low-calorie foods was measured...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28649672/oxytocin-and-stress-related-disorders-neurobiological-mechanisms-and-treatment-opportunities
#15
Lauren M Sippel, Casey E Allington, Robert H Pietrzak, Ilan Harpaz-Rotem, Linda C Mayes, Miranda Olff
Novel pharmacotherapies that improve outcomes for individuals with stress-related psychiatric disorders are needed. The neurohormone oxytocin (OT) is a promising candidate given its influence on the social-emotional brain. In this review, we present an overview of evidence supporting OT's utility for treating major depressive disorder and posttraumatic stress disorder. We first discuss endogenous OT, which research suggests is not yet a reliable biomarker of stress-related disorders. Second, we review effects of intranasal (IN) OT on processes relevant to stress-related disorders in healthy populations (anhedonia, reward processing, psychosocial stress reactivity, fear/anxiety, and social behavior) and their neurobiological mechanisms (e...
February 2017: Chronic stress
https://www.readbyqxmd.com/read/28629540/kinetics-and-dose-dependency-of-intranasal-oxytocin-effects-on-amygdala-reactivity
#16
Franny B Spengler, Johannes Schultz, Dirk Scheele, Maximiliane Essel, Wolfgang Maier, Markus Heinrichs, René Hurlemann
BACKGROUND: Current neuroimaging perspectives on a variety of mental disorders emphasize dysfunction of the amygdala. The neuropeptide oxytocin (OXT), a key mediator in the regulation of social cognition and behavior, accumulates in cerebrospinal fluid after intranasal administration in macaques and humans and modulates amygdala reactivity in both species. However, the translation of neuromodulatory OXT effects to novel treatment approaches is hampered by the absence of studies defining the most effective dose and dose-response latency for targeting the amygdala...
May 10, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28624988/mifepristone-vs-balloon-catheter-for-labor-induction-in-previous-cesarean-a-randomized-controlled-trial
#17
Chanderdeep Sharma, Anjali Soni, Amit Gupta, Ashok Verma, Suresh Verma
OBJECTIVE: To compare oral mifepristone (400 mg) with trans-cervical balloon catheter for induction of labor (IOL) in post date women with previous one cesarean section (CS). METHODS: In this randomized trial, post date pregnant women (gestation 40 weeks 5 days), with previous one low segment CS (no previous vaginal delivery) were induced either with oral mifepristone (400 mg) or balloon catheter [Foley's catheter (16 Fr); bulb filled with 30 ml normal saline]...
August 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28623008/yucca-schidigera-can-promote-rabbit-growth-fecundity-affect-the-release-of-hormones-in-vivo-and-in-vitro-induce-pathological-changes-in-liver-and-reduce-ovarian-resistance-to-benzene
#18
Martina Földešiová, Andrej Baláži, Ľubica Chrastinová, Juraj Pivko, Jan Kotwica, Abdel Halim Harrath, Peter Chrenek, Alexander V Sirotkin
This study evaluated the effect of Yucca schidigera (YS) extract on the physiological, reproductive, and endocrine indexes of New Zealand White rabbit does. Six-week-old rabbit does were fed a standard diet (control group) or a diet enriched with 5 or 20g of Y powder extract per 100-kg feed mixture for 350days. The does were artificially inseminated after induction of superovulation. Weight gain; conception and kindling rate; viability of pups and mothers; histopathological state of liver and muscle; plasma levels of progesterone (P4), oxytocin (OT), and prostaglandin F (PGF); and the release of P4, insulin-like growth factor I (IGF-I), OT, and PGF by isolated ovarian fragments and their response to the addition of benzene were analyzed...
June 10, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28590943/suppressed-play-behaviour-and-decreased-oxytocin-receptor-binding-in-the-amygdala-after-prenatal-exposure-to-low-dose-valproic-acid
#19
Freja Bertelsen, Davide Folloni, Arne Møller, Anne M Landau, Jørgen Scheel-Krüger, Michael Winterdahl
To better understand the role of the neuropeptide oxytocin in autism spectrum disorder (ASD), we investigated potential deficits in social play behaviour and oxytocin receptor (OXTR) density alterations in the amygdala in a rodent model of ASD. Pregnant rats were injected daily with 20 or 100 mg/kg valproic acid (VPA) or saline from day 12 until the end of pregnancy. The number of pinning and pouncing events was assessed at postnatal days 29-34. Brains from male offspring (n=7/group) were removed at postnatal day 50...
September 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28590768/effect-of-hydroalcoholic-extract-of-capsella-bursa-pastoris-on-early-postpartum-hemorrhage-a-clinical-trial-study
#20
Sahar Ghalandari, Nourossadat Kariman, Zohre Sheikhan, Faraz Mojab, Moghadameh Mirzaei, Hadis Shahrahmani
OBJECTIVES: Postpartum hemorrhage (PPH) is one of three main causes of maternal mortality and a life-threatening condition throughout the world. PPH can have irreversible complications for the mother even if it does not lead to death. This study was conducted to determine the effect of hydroalcoholic extract of Capsella bursa pastoris on early PPH. DESIGN: The present study was a single-blinded, randomized, clinical trial. SETTING: The study was conducted in Afzalipour Hospital of Kerman in 2015...
June 7, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
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