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Oxytocin dosing

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https://www.readbyqxmd.com/read/29306965/differential-activation-of-arginine-vasopressin-receptor-subtypes-in-the-amygdaloid-modulation-of-anxiety-in-the-rat-by-arginine-vasopressin
#1
Oscar René Hernández-Pérez, Minerva Crespo-Ramírez, Yordanka Cuza-Ferrer, José Anias-Calderón, Limei Zhang, Gabriel Roldan-Roldan, Raúl Aguilar-Roblero, Dasiel O Borroto-Escuela, Kjell Fuxe, Miguel Perez de la Mora
RATIONALE: The amygdala plays a paramount role in the modulation of anxiety and numerous studies have shown that arginine vasopressin (AVP) elicits anxiogenic effects following either its systemic or septal administration. OBJECTIVES: The aim of this paper was to study the involvement of vasopressinergic neurotransmission in the amygdaloid modulation of unconditioned anxiety and to ascertain whether or not AVP receptor subtypes may have a differential role in this modulation...
January 7, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29305879/reproductive-stage-and-sex-dependant-effects-of-neurohypophyseal-nonapeptides-on-gonadotropin-subunit-mrna-expression-in-the-catfish-heteropneustes-fossilis-an-in-vitro-study
#2
A Acharjee, R Chaube, K P Joy
In the present study, in vitroeffects of synthetic vasotocin (VT), isotocin (4Ser, 8Ile- oxytocin; ITb) and the recently cloned IT gene paralog product (8Val-Isotocin, ITa) were studied onthe expression of pituitary gonadotropin (GtH) subunit mRNA levels. In male pituitaries of early (preparatory phase) and late (prespawning phase) recrudescing catfish, Heteropneustes fossilis, VT (10 nM, 100 nM and 1000 nM) stimulated fshβ expression dose-dependently. But in females, the dose-dependent effect was found only in the preparatory phase...
January 3, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29276166/accelerated-titration-of-oxytocin-in-nulliparous-women-with-labour-dystocia-results-of-the-action-pilot-randomized-controlled-trial
#3
Jessica Dy, Jenna Rainey, Mark C Walker, William Fraser, Graeme N Smith, Ruth Rennicks White, Patti Waddell, Ghayath Janoudi, Daniel J Corsi, Shu Qin Wei
OBJECTIVE: The primary objective was to determine the feasibility of a large RCT assessing the effectiveness of an accelerated oxytocin titration (AOT) protocol compared with a standard gradual oxytocin titration (GOT) in reducing the risk of CS in nulliparous women diagnosed with dystocia in the first stage of labour. The secondary objective was to obtain preliminary data on the safety and efficacy of the foregoing AOT protocol. METHODS: This was a multicentre, double-masked, parallel-group pilot RCT...
December 21, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29240650/oxytocin-use-in-labor-legal-implications
#4
Susan Drummond
Oxytocin is one of the most commonly used medications in obstetrics and has been associated with claims of negligence in cases of adverse outcomes. Errors involving intravenous oxytocin administration for induction or augmentation of labor are most commonly dose related and include failure to avoid or treat tachysystole or failure to asses or treat a fetal heart rate pattern indicative of disruption in oxygenation. Clinicians should be knowledgeable regarding pharmacokinetics of oxytocin and the effect of uterine contractions on fetal oxygenation as well as safe titration of oxytocin to achieve the desired effect while minimizing harm...
December 13, 2017: Journal of Perinatal & Neonatal Nursing
https://www.readbyqxmd.com/read/29228453/effects-of-erythropoietin-on-spontaneous-and-oxytocin-induced-myometrial-contractions-in-the-nonpregnant-rat
#5
N Tug, H Ayvaci Tasan, M A Sargin, B Dogan Taymur, A Ayar, E Kilic, B Yilmaz
OBJECTIVE: Erythropoietin (EPO) is a glycoprotein hormone that regulates erythropoiesis. EPO activity has also been detected in a variety of tissue including the nervous system, and female and male reproductive organs. It has been shown that EPO causes relaxation in vascular smooth muscle. In the present study, we have investigated effects of EPO on spontaneous and oxytocin-induced contractions of non-pregnant rat myometrium. MATERIALS AND METHODS: Myometrial stripes were obtained from adult Wistar rats at the oestrous stage...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29217922/effect-of-solanum-nigrun-on-uterus-of-non-gravid-rats
#6
Freddy O Agoreyo, B Rita Ohimai, Magdalene I Omigie
Background: Solanum nigrum is a widely used plant in oriental medicine where it is considered to be antioxidant, anti- inflammatory and diuretic. This study aimed to evaluate the effect of Solanum Nigrum on uterine contractions. Method: Female Wistar Wister albino rats were used for the study. They were housed in a single large cage in an atmospheric controlled environment. Twenty-four hours before every experiment, 0.2 mg/kg of diethylstilbesterol constituted in 1:1 ethanol/water solution, was administered intraperitoneally as a pre-treatment to the rats to induce oestrus...
May 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217858/effect-of-co-administration-of-different-doses-of-phenylephrine-with-oxytocin-on-the-prevention-of-oxytocin-induced-hypotension-in-caesarean-section-under-spinal-anaesthesia-a-randomised-comparative-study
#7
Ranjitha Gangadharaiah, Devika Rani Duggappa, Sudheesh Kannan, S B Lokesh, Karuna Harsoor, K M Sunanda, S S Nethra
Introduction: Co-administration of phenylephrine prevents oxytocin-induced hypotension during caesarean section under spinal anaesthesia (SA), but higher doses cause reflex bradycardia. This study compares the effects of co-administration of two different doses of phenylephrine on oxytocin-induced hypotension during caesarean section under SA. Methods: In this prospective, double-blind study, 90 parturients belonging to the American Society of Anesthesiologists' physical status 1 or 2, undergoing caesarean section under SA were randomised into Group A: oxytocin 3U and phenylephrine 50 μg, Group B: oxytocin 3U and phenylephrine 75 μg, Group C: oxytocin 3U and normal saline, administered intravenously over 5 min after baby extraction...
November 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29187156/lack-of-controlled-studies-investigating-the-risk-of-postpartum-haemorrhage-in-cesarean-delivery-after-prior-use-of-oxytocin-a-scoping-review
#8
Karin Bischoff, Monika Nothacker, Cornelius Lehane, Britta Lang, Joerg Meerpohl, Christine Schmucker
BACKGROUND: Postpartum haemorrhage (PPH) is a major cause of maternal mortality and morbidity worldwide. Experimental and clinical studies indicate that prolonged oxytocin exposure in the first or second stage of labour may be associated with impaired uterine contractility and an increased risk of atonic PPH. Therefore, particularly labouring women requiring cesarean delivery constitute a subset of patients that may exhibit an unpredictable response to oxytocin. We mapped the evidence for comparative studies investigating the hypothesis whether the risk for PPH is increased in women requiring cesarean section after induction or augmentation of labour...
November 29, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29184844/effect-of-different-doses-of-oxytocin-on-cardiac-electrophysiology-and-arrhythmias-induced-by-ischemia
#9
Fariba Houshmand, Mahdieh Faghihi, Alireza Imani, Soleiman Kheiri
The onset of acute myocardial ischemia (MI) is accompanied by a rapid increase in electrical instability and often fatal ventricular arrhythmias. This study investigated that whether oxytocin (OT) can modulate ischemia-induced arrhythmias and considered relationships between the severity of arrhythmia and the electrocardiogram parameters during ischemia. OT (0.0001-1 μg) was administrated intraperitoneally 30 min before ischemia. To examine receptor involved, a selective OT-receptor antagonist, atosiban (ATO), was infused 10 min before OT...
October 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29183825/chronic-intranasal-oxytocin-has-dose-dependent-effects-on-central-oxytocin-and-vasopressin-systems-in-prairie-voles-microtus-ochrogaster
#10
C D Guoynes, T C Simmons, G M Downing, S Jacob, M Solomon, K L Bales
Oxytocin (Oxt) is a neuropeptide with many functions, including modulation of social behavior(s) and anxiety. Due to its notable pro-social effects, it has been proposed as a treatment in the management of neuropsychiatric disorders, such as autism spectrum disorder (ASD), schizophrenia, and social anxiety; however, effects of long-term daily treatment are still being explored. Previously, we have shown that in male prairie voles (Microtus ochrogaster) exposure to Oxt during the peri-adolescent period impaired adult pair bonding in a dose-dependent fashion...
November 25, 2017: Neuroscience
https://www.readbyqxmd.com/read/29169960/oxytocin-inhibits-the-rat-medullary-dorsal-horn-sp5c-c1-nociceptive-transmission-through-ot-but-not-v1a-receptors
#11
Enrique García-Boll, Guadalupe Martínez-Lorenzana, Miguel Condés-Lara, Abimael González-Hernández
The medullary dorsal horn (MDH or Sp5c/C1 region) plays a key role modulating the nociceptive input arriving from craniofacial structures. Some reports suggest that oxytocin could play a role modulating the nociceptive input at the MDH level, but no study has properly tested this hypothesis. Using an electrophysiological and pharmacological approach, the present study aimed to determine the effect of oxytocin on the nociceptive signaling in the MDH and the receptor involved. In sevoflurane, anesthetized rats, we performed electrophysiological unitary recordings of second order neurons at the MDH region responding to peripheral nociceptive-evoked responses of the first branch (V1; ophthalmic) of the trigeminal nerve...
November 20, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29157488/l%C3%A2-hypophyse-et-ses-traitements-comment-peuvent-ils-influer-sur-le-comportement-the-pituitary-and-its-treatments-how-can-they-influence-behaviour
#12
C Mouly, F Borson-Chazot, P Caron
Behaviour may be influenced by pituitary hormones or treatments. Dopamine agonist (DA) indicated in prolactinomas treatment can cause side effects, and especially impulse control disorders. In the context of prolactinomas treatment, impulse control disorders (ICD) have been reported like gambling, compulsive shopping, but mostly hypersexuality. These ICD can occur with low AD doses, and seem to be independent of type of molecule and psychiatric medical history. The main pathophysiologic hypothesis is a dysregulation of dopaminergic pathway involved in reward system...
October 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29151071/an-observational-cohort-study-of-3-units-versus-5-units-slow-intravenous-bolus-oxytocin-in-women-undergoing-elective-caesarean-delivery
#13
N Terblanche, P Otahal, A Messmer, P Wright, S Patel, K Nathan, J E Sharman
This study sought to compare postpartum blood loss and maternal outcomes after 3IU and 5IU oxytocin at elective caesarean delivery. In a prospective observational study, 73 women undergoing elective caesarean delivery under spinal anaesthetic received a slow I.V. injection of either 3IU (n = 35) or 5IU (n = 38) oxytocin after delivery. The main outcome was gravimetrically measured 24-hour postpartum blood loss with a non-inferiority margin of 300 mL. Uterine tone, phenylephrine dose, emesis and hypotension after oxytocin administration were secondary outcomes...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29141373/-a-concentration-response-observation-of-hydromorphone-combined-with-ropivacaine-in-labor-analgesia
#14
Y Y Lu, H Huang, W L Mao, R H Liu, M J Hu, L X Shao, M P Hu, J Li
Objective: To investigate the median effective dose (ED(50)) of hydromorphone and the appropriate concentration of ropivacaine combined with hydromorphone in epidural labor analgesia. Methods: One hundred and forty nulliparous women undergoing labor selected for delivery with epidural analgesia were enrolled in our hospital from January to June 2016. The first of top 50 women received 0.12% ropivacaine plus 20 μg/ml hydromorphone complex solution, then sequential women were used the modified sequential method to determine the ED(50) and ED(95) of hydromorphone...
November 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29136956/antagonistic-effect-of-oxytocin-and-tacrolimus-combination-on-adipose-tissue-derived-mesenchymal-stem-cells-antagonistic-effect-of-oxytocin-and-tacrolimus-antagonistic-effect-of-oxytocin-and-tacrolimus
#15
Gozde Sir, Bakiye Goker Bagca, Gurkan Yigitturk, Turker Cavusoglu, Cigir Biray Avci, Cumhur Gunduz, Yigit Uyanikgil
Tacrolimus (FK506) is a chemotherapeutic agent, which uses calcineurin pathway via inhibiting the stimulation of T cells to prevent the formation of immune response in the recipient individual in organ transplants. FK506 is mainly metabolized in the liver by cytochrome P450 enzyme system and is known that it has high toxic effects on different cells. Mesenchymal stem cells (MSCs) have recently gained importance since their potential to be used in cellular therapy and tissue regeneration. In some clinical cases, MSCs are transferred into the patient after the organ transplantations in order to support the treatment...
November 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29119727/monosodium-glutamate-suppresses-the-female-reproductive-function-by-impairing-the-functions-of-ovary-and-uterus-in-rat
#16
Mukti Mondal, Kaushik Sarkar, Partha Pratim Nath, Goutam Paul
The aim of the present study was to examine the effect of monosodium glutamate (MSG) on the functions of ovary and uterus in rat. Virgin female rats of Charles Foster strain (120 gms approximately) were administrated MSG by oral gavage at a dose level of 0.8, 1.6, 2.4 gm/kgBW/day, respectively for 30 and 40 days duration. We observed a significant decrease in the duration of proestrus, estrus and metestrus phases, and increase in the duration of diestrus phase and diestrus index compared to control. We found significant increase in the levels of serum LH, FSH and estradiol in test groups of rat...
November 9, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29107246/the-inhibition-of-myometrial-contractions-by-chlorinated-herbicides-atrazine-and-linuron-and-their-disruptive-effect-on-the-secretory-functions-of-uterine-and-ovarian-cells-in-cow-in-vitro
#17
Michał H Wrobel, Jaroslaw Mlynarczuk
The effect of atrazine and linuron, the popular and widely used chlorinated herbicides, on both myometrial contractions and secretory functions of bovine uterus and ovaries in vitro, was investigated. The pesticides inhibited (P<0.05) the basal and oxytocin (OT)-stimulated myometrial strips contractions, as well as the effect of OT on secretion of prostaglandins (PGs: PGF2α and PGE2) from endometrium. But only linuron inhibits the effect of OT on myometrial contractions. Neither of herbicides affected PGs secretion from myometrium and PGF2α from endometrium...
October 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29099900/comparison-of-the-endocrinological-and-immunological-results-of-different-induction-of-parturition-methods-in-ewes
#18
Emsal Sinem Özdemir Salci, Serpil Kahya Demirbilek, Nazmiye Gunes, Gülşen Goncagül, Ender Uzabacı, Tayfun Carli, Kamil Seyrek-Intas
OBJECTIVE: This study aimed to compare different induction of parturition (IP) methods in terms of endocrinological and immunological parameters in ewes and lambs. MATERIALS AND METHODS: A total of 24 ewes and their respective 24 lambs were studied. Groups of six ewes were induced on the 138th day: groups I (control), II (dexamethasone), III (aglepristone) and IV (aglepristone + dexamethasone). Blood samples were taken from the ewes from IP to 2 days postpartum at 12-hour intervals for the prolactin and oxytocin analyses...
November 3, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/29097150/prenatal-bisphenol-a-bpa-exposure-alters-the-transcriptome-of-the-neonate-rat-amygdala-in-a-sex-specific-manner-a-clarity-bpa-consortium-study
#19
Sheryl E Arambula, Dereje Jima, Heather B Patisaul
Bisphenol A (BPA) is a widely recognized endocrine disruptor prevalent in many household items. Because experimental and epidemiological data suggest links between prenatal BPA exposure and altered affective behaviors in children, even at levels below the current US FDA No Observed Adverse Effect Level (NOAEL) of 5mg/kg body weight (bw)/day, there is concern that early life exposure may alter neurodevelopment. The current study was conducted as part of the CLARITY-BPA (Consortium Linking Academic and Regulatory Insights on BPA Toxicity) program and examined the full amygdalar transcriptome on postnatal day (PND) 1, with the hypothesis that prenatal BPA exposure would alter the expression of genes and pathways fundamental to sex-specific affective behaviors...
October 28, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/29066224/oxytocin-receptors-in-the-anteromedial-bed-nucleus-of-the-stria-terminalis-promote-stress-induced-social-avoidance-in-female-california-mice
#20
Natalia Duque-Wilckens, Michael Q Steinman, Marta Busnelli, Bice Chini, Sae Yokoyama, Mary Pham, Sarah A Laredo, Rebecca Hao, Allison M Perkeybile, Vanessa A Minie, Phillip B Tan, Karen L Bales, Brian C Trainor
BACKGROUND: The neuropeptide oxytocin (OT) is a key regulator of social and emotional behaviors. The effects of OT are context dependent, and it has been proposed that OT increases the salience of both positive and negative social cues. Here we tested whether the bed nucleus of the stria terminalis (BNST) mediates anxiogenic effects of OT. METHODS: First, we studied the effects of systemic administration of an OT receptor (OTR) antagonist L-368,899 on social behavior in male and female California mice exposed to social defeat...
September 14, 2017: Biological Psychiatry
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