keyword
MENU ▼
Read by QxMD icon Read
search

Oxytocin dosing

keyword
https://www.readbyqxmd.com/read/28930284/effects-of-intranasal-oxytocin-on-the-blood-oxygenation-level-dependent-signal-in-food-motivation-and-cognitive-control-pathways-in-overweight-and-obese-men
#1
Franziska Plessow, Dean A Marengi, Sylvia K Perry, Julia M Felicione, Rachel Franklin, Tara M Holmes, Laura M Holsen, Nikolaos Makris, Thilo Deckersbach, Elizabeth A Lawson
Recent research indicates that the hypothalamic neuropeptide hormone oxytocin is a key central nervous system factor in the regulation of food intake and weight. However, the mechanisms underlying the anorexigenic effects of oxytocin in humans are unknown and critical to study in order to consider oxytocin as a neurohormonal weight loss treatment. We performed a randomized, double-blind, placebo-controlled crossover study with single-dose intranasal oxytocin (24 IU) in ten overweight or obese, otherwise healthy men...
September 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28916137/oxytocin-induces-penile-erection-and-yawning-when-injected-into-the-bed-nucleus-of-the-stria-terminalis-involvement-of-glutamic-acid-dopamine-and-nitric-oxide
#2
Fabrizio Sanna, Jessica Bratzu, Antonio Argiolas, Maria Rosaria Melis
Oxytocin (5-100ng), but not Arg(8)-vasopressin (100ng), injected unilaterally into the bed nucleus of the stria terminalis (BNST) induces penile erection and yawning in a dose-dependent manner in male rats. The minimal effective dose was 20ng for penile erection and 5ng for yawning. Oxytocin responses were abolished not only by the oxytocin receptor antagonist d(CH2)5Tyr(Me)(2)-Orn(8)-vasotocin (1μg), but also by (+) MK-801 (1μg), an excitatory amino acid receptor antagonist of the N-methyl-d-aspartic acid (NMDA) subtype, SCH 23390 (1μg), a D1 receptor antagonist, but not haloperidol (1μg), a D2 receptor antagonist, and SMTC (40μg), an inhibitor of neuronal nitric oxide synthase, injected into the BNST 15min before oxytocin...
September 18, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28898687/outcomes-of-mifepristone-usage-for-cervical-ripening-and-induction-of-labour-in-full-term-pregnancy-randomized-controlled-trial
#3
Oleg R Baev, Valentina P Rumyantseva, Oleg V Tysyachnyu, Olga A Kozlova, Gennady T Sukhikh
OBJECTIVE: The most commonly used approved indications for mifepristone in obstetrics include: termination of early pregnancy, cervical dilatation prior to abortion, labour induction in case of fetal death in utero. Fewer studies have been conducted on the effect of mifepristone on cervical ripening and induction of labour in term pregnancy with a live fetus. The aim of our study was to evaluate efficacy and safety of mifepristone use for cervical ripening and induction of labour versus expectant management in full-term pregnancy...
September 1, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28889775/high-dose-compared-to-low-dose-oxytocin-for-induction-of-labour-of-nulliparous-women-at-term
#4
Natasha Prichard, Anthea Lindquist, Richard Hiscock, Sophie Ruff, Stephen Tong, Fiona C Brownfoot
BACKGROUND: The optimal oxytocin infusion regimen to induce labour with the lowest caesarean section rate, instrumental delivery rate and length of active labour, is unclear. We compared the effect of a low-dose to high-dose oxytocin regimen to induce labour. MATERIALS AND METHODS: We conducted a retrospective study of nulliparous women induced at term in a single tertiary centre from 2009 to 2015. The oxytocin induction protocol changed from a high to low-dose regimen in November 2012, affording us the opportunity to compare outcomes 3 years prior to, and following the change in protocol...
September 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28886702/safety-and-effectiveness-of-oral-misoprostol-for-induction-of-labour-in-a-resource-limited-setting-a-dose-escalation-study
#5
Marilyn Morris, John W Bolnga, Ovoi Verave, Jimmy Aipit, Allanie Rero, Moses Laman
BACKGROUND: Oral misoprostol as an induction of labour (IOL) agent is rapidly gaining popularity in resource-limited settings because it is cheap, stable at ambient temperatures, and logistically easier to administer compared to dinoprostone and oxytocin. We aim to investigate the safety and effectiveness of a regimen of oral misoprostol in Papua New Guinean women undergoing IOL. METHODS: As part of a prospective dose escalation study conducted at Modilon Hospital in Papua New Guinea, women with a singleton pregnancy in cephalic presentation and an unfavourable cervix who gave written informed consent were administered oral misoprostol, commencing at 25mcg once every 2 h for 4 doses and increased to 50mcg once every 2 h for 8 doses within 24 h...
September 8, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28865224/direct-effect-of-hypothalamic-neuropeptides-on-the-release-of-catecholamines-by-adrenal-medulla-in-sheep-study-ex-vivo
#6
D Wrońska, B F Kania, M Błachuta
Stress causes the activation of both the hypothalamic-pituitary-adrenocortical axis and sympatho-adrenal system, thus leading to the release from the adrenal medulla of catecholamines: adrenaline and, to a lesser degree, noradrenaline. It has been established that in addition to catecholamines, the adrenomedullary cells produce a variety of neuropeptides, including corticoliberine (CRH), vasopressin (AVP), oxytocin (OXY) and proopiomelanocortine (POMC) - a precursor of the adrenocorticotropic hormone (ACTH)...
March 1, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28864976/overview-of-human-oxytocin-research
#7
Keith M Kendrick, Adam J Guastella, Benjamin Becker
Social dysfunction is a core symptom of many psychiatric disorders and current medications have little or no remedial effects on this. Following on from extensive studies on animal models demonstrating that the neuropeptide oxytocin plays an important role in social recognition and bonding, human-based research has explored its therapeutic potential for social dysfunction in psychiatric disorders. Here we outline the historical background of this human-based research and some of the current methodological challenges it is facing...
September 2, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28858899/patients-undergoing-cesarean-delivery-after-exposure-to-oxytocin-during-labor-require-higher-postpartum-oxytocin-doses
#8
Amanda Foley, Ashley Gunter, Kenneth J Nunes, Sajid Shahul, Barbara M Scavone
BACKGROUND: Experts recommend postpartum oxytocin to prevent uterine atony and hemorrhage, but oxytocin may be associated with dose-dependent adverse effects, and the correct dose of postpartum oxytocin has yet to be determined. The effective dose in 90% of patients (ED90) of oxytocin after cesarean delivery may be higher in patients exposed to oxytocin during labor compared to patients unexposed. We therefore undertook this study to compare postpartum oxytocin requirements in patients exposed to oxytocin prior to cesarean delivery versus those not exposed, when all were treated according to a specific institutional protocol...
August 30, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28855876/the-non-peptide-arginine-vasopressin-v1a-selective-receptor-antagonist-sr49059-blocks-the-rewarding-prosocial-and-anxiolytic-effects-of-3-4-methylenedioxymethamphetamine-and-its-derivatives-in-zebra-fish
#9
Luisa Ponzoni, Daniela Braida, Gianpietro Bondiolotti, Mariaelvina Sala
3,4-Methylenedioxymethamphetamine (MDMA) and its derivatives, 2,5-dimethoxy-4-bromo-amphetamine hydrobromide (DOB) and para-methoxyamphetamine (PMA), are recreational drugs whose pharmacological effects have recently been attributed to serotonin 5HT2A/C receptors. However, there is growing evidence that the oxytocin (OT)/vasopressin system can modulate some the effects of MDMA. In this study, MDMA (2.5-10 mg/kg), DOB (0.5 mg/kg), or PMA (0.005, 0.1, or 0.25 mg/kg) were administered intramuscularly to adult zebra fish, alone or in combination with the V1a vasopressin antagonist, SR49059 (0...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28837950/meta-analytic-review-of-the-effects-of-a-single-dose-of-intranasal-oxytocin-on-threat-processing-in-humans
#10
REVIEW
Jenni Leppanen, Kah Wee Ng, Youl-Ri Kim, Kate Tchanturia, Janet Treasure
BACKGROUND: Heightened threat sensitivity is a transdiagnostic feature in several psychiatric disorders. The neuropeptide oxytocin has been shown to reduce fear related behaviours and facilitated fear extinction in animals. These findings have led to increasing interest to explore the effects of intranasal oxytocin on threat processing in humans. METHODS: The review included 26 studies (N = 1173), nine of which included clinical populations (N = 234). The clinical groups included were people with borderline personality disorder (BPD), anorexia nervosa, bulimia nervosa, depression, anxiety, and alcohol dependence disorder...
August 17, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28831553/efficacy-and-safety-of-misoprostol-dinoprostone-and-cook-s-balloon-for-labour-induction-in-women-with-foetal-growth-restriction-at-term
#11
Jorge Duro-Gómez, María Fernanda Garrido-Oyarzún, Ana Belén Rodríguez-Marín, Antonio Jesús de la Torre González, José Eduardo Arjona-Berral, Camil Castelo-Branco
BACKGROUND AND OBJECTIVES: To compare effectiveness and safety of dinoprostone, misoprostol and Cook's balloon as labour-inducing agents in women with intrauterine growth restriction (IUGR) at term. METHODS: Retrospective cohort chart review of women diagnosed with foetal growth restriction at term in Reina Sofia Hospital, Cordoba, Spain from January 2014 to December 2015. Registration of baseline characteristics and method of induction was made. The main outcome was time from induction to delivery...
August 22, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28797187/a-survey-of-physicians-attitudes-toward-uterotonic-administration-in-parturients-undergoing-cesarean-section
#12
Sharon Orbach-Zinger, Sharon Einav, Assaf Yonah, Leonid A Eidelman, Shia Fein, Atara Davis Ba, Alexander Ioscovich
OBJECTIVE: Oxytocin is globally accepted as first line treatment for prevention of post partum hemorrhage. However there is wide variability in its use in clinical practice. In this study we aimed to evaluate obstetricians and anesthesiologists attitudes towards uterotonic practices in Israel. STUDY DESIGN: The current survey was designed to study the preferences of obstetricians and anesthesiologists in seven University hospitals regarding the type, dose and mode of administration of uterotonic drugs, as well as their knowledge regarding the side effects of these drugs...
August 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28781129/safety-tolerability-and-pharmacokinetics-of-single-doses-of-oxytocin-administered-via-an-inhaled-route-in-healthy-females-randomized-single-blind-phase-1-study
#13
Disala Fernando, Sarah Siederer, Sunita Singh, Ian Schneider, Ashutosh Gupta, Marcy Powell, Duncan Richards, Michelle P McIntosh, Peter Lambert, Susan Fowles
BACKGROUND: The utility of intramuscular (IM) oxytocin for the prevention of postpartum hemorrhage in resource-poor settings is limited by the requirement for temperature-controlled storage and skilled staff to administer the injection. We evaluated the safety, tolerability and pharmacokinetics (PK) of a heat-stable, inhaled (IH) oxytocin formulation. METHODS: This phase 1, randomized, single-center, single-blind, dose-escalation, fixed-sequence study (NCT02542813) was conducted in healthy, premenopausal, non-pregnant, non-lactating women aged 18-45years...
August 2017: EBioMedicine
https://www.readbyqxmd.com/read/28770970/oxtr-and-zeb1-expression-before-and-after-progesterone-dosing-in-pregnant-women-with-threatened-premature-labor
#14
Y-J Xu, L-D Ren, S-S Zhai, L-M Ran, L-L Hu, X-H Luo, T Hong, R Liu, Y-R Yu, Y-J Ban
OBJECTIVE: To investigate changes in the peripheral blood mRNA levels of oxytocin receptor (OXTR) and Zinc finger E-box-binding homeobox 1 (ZEB1) before and after progesterone dosing in pregnant women with threatened premature labor. PATIENTS AND METHODS: Blood samples were collected from 30 healthy pregnant women with 28- to 33+6-week gestational age and singleton pregnancy (group A) and from 30 pregnant women with singleton pregnancy and threatened premature labor before and 48 hours after progesterone dosing (groups B and C, respectively) for quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) assay to assess the OXTR and ZEB1 mRNA levels...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28766270/oxytocin-and-autism-spectrum-disorders
#15
Hidenori Yamasue, Gregor Domes
Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose core symptoms include deficits in social interaction and communication besides restricted and repetitive behaviors. Although ASD is highly prevalent, affecting 1/100 in the general population, no medication for the core symptoms has been established. Therefore, the disorder is considered a huge unmet medical need and a heavy burden on individuals with ASD, their families, and entire society. Oxytocin is expected to be a potential therapeutic resource for the social core symptoms of ASD, since this neuropeptide can modulate human social behavior and cognition...
August 2, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28765081/intranasal-oxytocin-and-a-polymorphism-in-the-oxytocin-receptor-gene-are-associated-with-human-directed-social-behavior-in-golden-retriever-dogs
#16
Mia E Persson, Agaia J Trottier, Johan Bélteky, Lina S V Roth, Per Jensen
The oxytocin system may play an important role in dog domestication from the wolf. Dogs have evolved unique human analogue social skills enabling them to communicate and cooperate efficiently with people. Genomic differences in the region surrounding the oxytocin receptor (OXTR) gene have previously been associated with variation in dogs' communicative skills. Here we have utilized the unsolvable problem paradigm to investigate the effects of oxytocin and OXTR polymorphisms on human-directed contact seeking behavior in 60 golden retriever dogs...
August 17, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28764883/involvement-of-gabaa-receptors-in-the-regulation-of-social-preference-and-emotional-behaviors-by-oxytocin-in-the-central-amygdala-of-female-mandarin-voles
#17
Na Dong, Peirong Du, Xin Hao, Zhixiong He, Wenjuan Hou, Limin Wang, Wei Yuan, Jinfeng Yang, Rui Jia, Fadao Tai
The central nucleus of the amygdala (CeA) is the main output of the amygdala and plays an important role in behavioral and neuroendocrine responses to stress. Receptors for the neuropeptide oxytocin (OT) and GABAA are found in high concentration in the CeA. The mechanisms underlying regulation of CeA OT in emotional and social behavior remain unclear. In this study we evaluated the effects of intra-CeA OT administration of different doses (0.1, 1 and 10ng/side), OT receptor antagonist (OTR-A) (1, 10 and 100ng/side) and OT plus OTR-A on social and emotional behavior using a social preference paradigm, open field test and elevated plus maze test in female monogamous mandarin voles (Microtus mandarinus)...
July 25, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28721467/a-review-of-the-safety-efficacy-and-mechanisms-of-delivery-of-nasal-oxytocin-in-children-therapeutic-potential-for-autism-and-prader-willi-syndrome-and-recommendations-for-future-research
#18
Marilena M DeMayo, Yun Ju C Song, Ian B Hickie, Adam J Guastella
In this article, we conduct a comprehensive review of existing evidence for the safety and therapeutic potential of intranasal oxytocin in pediatric populations. Unique considerations for dosing and delivery of oxytocin to the nasal passageway in pediatric populations and methods to promote adherence are reviewed. Intranasal oxytocin has been administered to 261 children in three open-label studies and eight randomized controlled trials. To date, the only published results in pediatric populations have focused on autism spectrum disorder (ASD) and Prader-Willi syndrome (PWS)...
July 18, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28707488/efficacy-of-oxytocin-versus-carbetocin-in-prevention-of-postpartum-hemorrhage-after-cesarean-section-under-general-anesthesia-a-prospective-randomized-clinical-trial
#19
Robabeh Taheripanah, Amal Shoman, Mohammad Ali Karimzadeh, Marzieh Zamaniyan, Narges Malih
OBJECTIVE: To compare the use of carbetocin and oxytocin in the prevention of postpartum hemorrhage after cesarean section. METHODS: The present study was a prospective double-blind randomized controlled clinical trial performed in two university-based hospitals in Tehran, Iran. Two hundred and twenty women with the gestational age of more than 37 weeks, who needed cesarean operation, participated in the study. Patients were assigned to receive either a single 100 μg IV dose of carbetocin or a standard 30-international unit IV infusion of oxytocin during 2 h after delivery of placenta...
July 25, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28697540/three-doses-of-oral-misoprostol-versus-an-intra-cervical-foley-catheter-for-24-hours-for-pre-induction-cervical-ripening-in-post-dated-pregnancies-a-randomized-controlled-trial
#20
D Somirathne, Malik Goonewardene, L Dahanayake
Objectives: To compare three doses of oral misoprostol 50μg four hourly versus an intra-cervical Foley catheter for 24 hours, for pre-induction cervical ripening. Methods: Primary investigator blinded, randomised controlled trial conducted in 180 consecutive women with singleton uncomplicated pregnancies with Modified Bishop Score (MBS) 5 at 40 weeks + 6 days gestation, allocated by stratified (primigravida / multigravida) block randomization to receive three doses of oral misoprostol 50μg four hourly or an intra-cervical Foley catheter for 24 hours...
June 30, 2017: Ceylon Medical Journal
keyword
keyword
104339
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"