keyword
MENU ▼
Read by QxMD icon Read
search

Oxytocin dosing

keyword
https://www.readbyqxmd.com/read/29141373/-a-concentration-response-observation-of-hydromorphone-combined-with-ropivacaine-in-labor-analgesia
#1
Y Y Lu, H Huang, W L Mao, R H Liu, M J Hu, L X Shao, M P Hu, J Li
Objective: To investigate the median effective dose (ED(50)) of hydromorphone and the appropriate concentration of ropivacaine combined with hydromorphone in epidural labor analgesia. Methods: One hundred and forty nulliparous women undergoing labor selected for delivery with epidural analgesia were enrolled in our hospital from January to June 2016. The first of top 50 women received 0.12% ropivacaine plus 20 μg/ml hydromorphone complex solution, then sequential women were used the modified sequential method to determine the ED(50) and ED(95) of hydromorphone...
November 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29136956/antagonistic-effect-of-oxytocin-and-tacrolimus-combination-on-adipose-tissue-derived-mesenchymal-stem-cells-antagonistic-effect-of-oxytocin-and-tacrolimus-antagonistic-effect-of-oxytocin-and-tacrolimus
#2
Gozde Sir, Bakiye Goker Bagca, Gurkan Yigitturk, Turker Cavusoglu, Cigir Biray Avci, Cumhur Gunduz, Yigit Uyanikgil
Tacrolimus (FK506) is a chemotherapeutic agent, which uses calcineurin pathway via inhibiting the stimulation of T cells to prevent the formation of immune response in the recipient individual in organ transplants. FK506 is mainly metabolized in the liver by cytochrome P450 enzyme system and is known that it has high toxic effects on different cells. Mesenchymal stem cells (MSCs) have recently gained importance since their potential to be used in cellular therapy and tissue regeneration. In some clinical cases, MSCs are transferred into the patient after the organ transplantations in order to support the treatment...
November 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29119727/monosodium-glutamate-suppresses-the-female-reproductive-function-by-impairing-the-functions-of-ovary-and-uterus-in-rat
#3
Mukti Mondal, Kaushik Sarkar, Partha Pratim Nath, Goutam Paul
The aim of the present study was to examine the effect of monosodium glutamate (MSG) on the functions of ovary and uterus in rat. Virgin female rats of Charles Foster strain (120 gms approximately) were administrated MSG by oral gavage at a dose level of 0.8, 1.6, 2.4 gm/kgBW/day, respectively for 30 and 40 days duration. We observed a significant decrease in the duration of proestrus, estrus and metestrus phases, and increase in the duration of diestrus phase and diestrus index compared to control. We found significant increase in the levels of serum LH, FSH and estradiol in test groups of rat...
November 9, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29107246/the-inhibition-of-myometrial-contractions-by-chlorinated-herbicides-atrazine-and-linuron-and-their-disruptive-effect-on-the-secretory-functions-of-uterine-and-ovarian-cells-in-cow-in-vitro
#4
Michał H Wrobel, Jaroslaw Mlynarczuk
The effect of atrazine and linuron, the popular and widely used chlorinated herbicides, on both myometrial contractions and secretory functions of bovine uterus and ovaries in vitro, was investigated. The pesticides inhibited (P<0.05) the basal and oxytocin (OT)-stimulated myometrial strips contractions, as well as the effect of OT on secretion of prostaglandins (PGs: PGF2α and PGE2) from endometrium. But only linuron inhibits the effect of OT on myometrial contractions. Neither of herbicides affected PGs secretion from myometrium and PGF2α from endometrium...
October 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29099900/comparison-of-the-endocrinological-and-immunological-results-of-different-induction-of-parturition-methods-in-ewes
#5
Emsal Sinem Özdemir Salci, Serpil Kahya Demirbilek, Nazmiye Gunes, Gülşen Goncagül, Ender Uzabacı, Tayfun Carli, Kamil Seyrek-Intas
OBJECTIVE: This study aimed to compare different induction of parturition (IP) methods in terms of endocrinological and immunological parameters in ewes and lambs. MATERIALS AND METHODS: A total of 24 ewes and their respective 24 lambs were studied. Groups of six ewes were induced on the 138th day: groups I (control), II (dexamethasone), III (aglepristone) and IV (aglepristone + dexamethasone). Blood samples were taken from the ewes from IP to 2 days postpartum at 12-hour intervals for the prolactin and oxytocin analyses...
November 3, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/29097150/prenatal-bisphenol-a-bpa-exposure-alters-the-transcriptome-of-the-neonate-rat-amygdala-in-a-sex-specific-manner-a-clarity-bpa-consortium-study
#6
Sheryl E Arambula, Dereje Jima, Heather B Patisaul
Bisphenol A (BPA) is a widely recognized endocrine disruptor prevalent in many household items. Because experimental and epidemiological data suggest links between prenatal BPA exposure and altered affective behaviors in children, even at levels below the current US FDA No Observed Adverse Effect Level (NOAEL) of 5mg/kg body weight (bw)/day, there is concern that early life exposure may alter neurodevelopment. The current study was conducted as part of the CLARITY-BPA (Consortium Linking Academic and Regulatory Insights on BPA Toxicity) program and examined the full amygdalar transcriptome on postnatal day (PND) 1, with the hypothesis that prenatal BPA exposure would alter the expression of genes and pathways fundamental to sex-specific affective behaviors...
October 28, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/29066224/oxytocin-receptors-in-the-anteromedial-bed-nucleus-of-the-stria-terminalis-promote-stress-induced-social-avoidance-in-female-california-mice
#7
Natalia Duque-Wilckens, Michael Q Steinman, Marta Busnelli, Bice Chini, Sae Yokoyama, Mary Pham, Sarah A Laredo, Rebecca Hao, Allison M Perkeybile, Vanessa A Minie, Phillip B Tan, Karen L Bales, Brian C Trainor
BACKGROUND: The neuropeptide oxytocin (OT) is a key regulator of social and emotional behaviors. The effects of OT are context dependent, and it has been proposed that OT increases the salience of both positive and negative social cues. Here we tested whether the bed nucleus of the stria terminalis (BNST) mediates anxiogenic effects of OT. METHODS: First, we studied the effects of systemic administration of an OT receptor (OTR) antagonist L-368,899 on social behavior in male and female California mice exposed to social defeat...
September 14, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29049935/intranasal-oxytocin-in-the-treatment-of-anorexia-nervosa-randomized-controlled-trial-during-re-feeding
#8
Janice Russell, Sarah Maguire, Glenn E Hunt, Alice Kesby, Anastasia Suraev, Jordyn Stuart, Jessica Booth, Iain S McGregor
BACKGROUND: Nutritional rehabilitation in anorexia nervosa (AN) is impeded by fear of food, eating and change leading to treatment resistance. Oxytocin (OT) exerts prosocial effects and modulates trust, fear, anxiety and neuroplasticity. The current placebo-controlled RCT examined the effects of intranasal oxytocin (IN-OT) in AN. The aim was to ascertain whether repeated doses of IN-OT enhance treatment outcomes in AN. METHODS: AN patients self-administered 36 IU IN-OT or placebo daily for 4-6 weeks during hospital treatment...
October 14, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29037599/neural-basis-of-ventromedial-hypothalamic-oxytocin-driven-decrease-in-appetite
#9
Oscar A Klockars, Joseph R Waas, Anica Klockars, Allen S Levine, Pawel K Olszewski
OBJECTIVES: Oxytocin (OT) administration in the ventromedial hypothalamic nucleus (VMH) reduces chow intake. The nature of VMH OT's anorexigenic action remains unclear. Here we provide insight into neural mechanisms underlying VMH OT-driven anorexia by (a) identifying feeding-related brain sites activated by VMH OT injection; (b) measuring VMH OT receptor (OTr) mRNA changes in response to hunger and palatability; and (c) examining how VMH OT affects episodic sweet solution intake in sated and hungry rats...
October 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/29032324/intranasal-oxytocin-social-cognition-and-neurodevelopmental-disorders-a-meta-analysis
#10
REVIEW
Britney Keech, Simon Crowe, Darren R Hocking
Deficits in social cognition are pervasive and characteristic of neurodevelopmental disorders (NDDs). Clinical trials of intranasal oxytocin (IN-OT) to improve social cognition have yielded inconclusive results. The current study is a meta-analysis of randomized controlled trials (RCTs) considering the effect of IN-OT on social cognitive domains across a range of NDDs. Medline, PsychINFO and Scopus were searched for RCTs published through to July 25, 2017. Seventeen studies met inclusion criteria, comprising 466 participants with a NDD...
October 8, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29029875/oxytocin-is-not-involved-in-luteolysis-and-early-maternal-recognition-of-pregnancy-mrp-in-alpacas
#11
Michela Ciccarelli, Muhammad Salman Waqas, James K Pru, Ahmed Tibary
Pregnancy maintenance depends on the maternal recognition of pregnancy (MRP), a physiological process by which the lifespan of the corpus luteum is prolonged. This mechanism is not well characterized in camelids. The objectives of the present research were to determine if exogenous oxytocin prolongs the corpus luteum activity in alpacas and to evaluate expression and localization of oxytocin receptors within the endometrium at 9 and 14days post-mating. In the oxytocin studies, plasma progesterone profiles were determined after ovulation in the same alpacas on 2 cycles: one cycle without oxytocin treatment and one cycle with oxytocin treatment...
October 6, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29021442/the-relationship-between-the-serum-oxytocin-levels-disease-activity-the-adls-and-the-qol-in-patients-with-rheumatoid-arthritis
#12
Yusuke Miwa, Hidekazu Furuya, Ryo Yanai, Tsuyoshi Kasama, Kenji Sanada
Objective To investigate the factors associated with depression, including the serum oxytocin (OXT) levels, disease activity, activities of daily living (ADLs) and quality of life (QOL), and their effects on rheumatoid arthritis (RA). Methods This study included 42-RA-patients. We measured the following variables before and after 6 months of treatment with biological disease-modifying anti rheumatic drugs (bDMARDs): the baseline characteristics (including age, sex, disease duration, smoking, and body mass index), the doses of prednisolone and methotrexate, the serum level of matrix metalloprotease-3, the erythrocyte sedimentation rate and the C-reactive protein level...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29016497/discontinuing-oxytocin-infusion-in-the-active-phase-of-labor-a-systematic-review-and-meta-analysis
#13
REVIEW
Gabriele Saccone, Andrea Ciardulli, Jason K Baxter, Joanne N Quiñones, Liany C Diven, Bor Pinar, Giuseppe Maria Maruotti, Pasquale Martinelli, Vincenzo Berghella
OBJECTIVE: To evaluate the benefits and harms of discontinuation of oxytocin after the active phase of labor is reached. DATA SOURCES: Electronic databases (ie, MEDLINE, Scopus, ClinicalTrials.gov, EMBASE, ScienceDirect, the Cochrane Library at the CENTRAL Register of Controlled Trials, Scielo) were searched from their inception until April 2017. METHODS OF STUDY SELECTION: We included all randomized controlled trials comparing discontinuation (ie, intervention group) and continuation (ie, control group) of oxytocin infusion after the active phase of labor is reached, either after induction or augmentation of labor...
November 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28983279/tinnitus-treatment-with-oxytocin-a-pilot-study
#14
Andreia Aparecida Azevedo, Ricardo Rodrigues Figueiredo, Ana Belen Elgoyhen, Berthold Langguth, Norma De Oliveira Penido, Winfried Schlee
INTRODUCTION: Tinnitus is the perception of sound in the absence of an external stimulus. It is a frequent condition for which there is as yet no pharmacological treatment approved. Auditory and non-auditory pathways are involved in tinnitus' pathophysiology. Oxytocin is a neurohormone and eventual neurotransmitter that plays a complex role in social cognition and behavior. OBJECTIVE: To evaluate the potential of oxytocin as a tinnitus treatment. STUDY DESIGN: Two studies were performed...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28960210/the-effects-of-oxytocin-on-eating-behaviour-and-metabolism-in-humans
#15
REVIEW
Elizabeth A Lawson
Oxytocin, a hypothalamic hormone that is secreted directly into the brain and enters the peripheral circulation through the posterior pituitary gland, regulates a range of physiologic processes, including eating behaviour and metabolism. In rodents and nonhuman primates, chronic oxytocin administration leads to sustained weight reduction by reducing food intake, increasing energy expenditure and inducing lipolysis. Oxytocin might improve glucose homeostasis, independently of its effects on weight. Clinical studies are beginning to translate these important preclinical findings to humans...
December 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28930284/effects-of-intranasal-oxytocin-on-the-blood-oxygenation-level-dependent-signal-in-food-motivation-and-cognitive-control-pathways-in-overweight-and-obese-men
#16
Franziska Plessow, Dean A Marengi, Sylvia K Perry, Julia M Felicione, Rachel Franklin, Tara M Holmes, Laura M Holsen, Nikolaos Makris, Thilo Deckersbach, Elizabeth A Lawson
Recent research indicates that the hypothalamic neuropeptide hormone oxytocin is a key central nervous system factor in the regulation of food intake and weight. However, the mechanisms underlying the anorexigenic effects of oxytocin in humans are unknown and critical to study in order to consider oxytocin as a neurohormonal weight loss treatment. We performed a randomized, double-blind, placebo-controlled crossover study with single-dose intranasal oxytocin (24 IU) in ten overweight or obese, otherwise healthy men...
September 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28916137/oxytocin-induces-penile-erection-and-yawning-when-injected-into-the-bed-nucleus-of-the-stria-terminalis-involvement-of-glutamic-acid-dopamine-and-nitric-oxide
#17
Fabrizio Sanna, Jessica Bratzu, Antonio Argiolas, Maria Rosaria Melis
Oxytocin (5-100ng), but not Arg(8)-vasopressin (100ng), injected unilaterally into the bed nucleus of the stria terminalis (BNST) induces penile erection and yawning in a dose-dependent manner in male rats. The minimal effective dose was 20ng for penile erection and 5ng for yawning. Oxytocin responses were abolished not only by the oxytocin receptor antagonist d(CH2)5Tyr(Me)(2)-Orn(8)-vasotocin (1μg), but also by (+) MK-801 (1μg), an excitatory amino acid receptor antagonist of the N-methyl-d-aspartic acid (NMDA) subtype, SCH 23390 (1μg), a D1 receptor antagonist, but not haloperidol (1μg), a D2 receptor antagonist, and SMTC (40μg), an inhibitor of neuronal nitric oxide synthase, injected into the BNST 15min before oxytocin...
September 18, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28898687/outcomes-of-mifepristone-usage-for-cervical-ripening-and-induction-of-labour-in-full-term-pregnancy-randomized-controlled-trial
#18
Oleg R Baev, Valentina P Rumyantseva, Oleg V Tysyachnyu, Olga A Kozlova, Gennady T Sukhikh
OBJECTIVE: The most commonly used approved indications for mifepristone in obstetrics include: termination of early pregnancy, cervical dilatation prior to abortion, labour induction in case of fetal death in utero. Fewer studies have been conducted on the effect of mifepristone on cervical ripening and induction of labour in term pregnancy with a live fetus. The aim of our study was to evaluate efficacy and safety of mifepristone use for cervical ripening and induction of labour versus expectant management in full-term pregnancy...
October 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28889775/high-dose-compared-with-low-dose-oxytocin-for-induction-of-labour-of-nulliparous-women-at-term
#19
Natasha Prichard, Anthea Lindquist, Richard Hiscock, Sophie Ruff, Stephen Tong, Fiona C Brownfoot
BACKGROUND: The optimal oxytocin infusion regimen to induce labour with the lowest caesarean section rate, instrumental delivery rate and length of active labour is unclear. We compared the effect of a low-dose to high-dose oxytocin regimen to induce labour. MATERIALS AND METHODS: We conducted a retrospective study of nulliparous women induced at term in a single tertiary centre from 2009 to 2015. The oxytocin induction protocol changed from a high to low-dose regimen in November 2012, affording us the opportunity to compare outcomes 3 years prior to, and following the change in protocol...
September 26, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28886702/safety-and-effectiveness-of-oral-misoprostol-for-induction-of-labour-in-a-resource-limited-setting-a-dose-escalation-study
#20
Marilyn Morris, John W Bolnga, Ovoi Verave, Jimmy Aipit, Allanie Rero, Moses Laman
BACKGROUND: Oral misoprostol as an induction of labour (IOL) agent is rapidly gaining popularity in resource-limited settings because it is cheap, stable at ambient temperatures, and logistically easier to administer compared to dinoprostone and oxytocin. We aim to investigate the safety and effectiveness of a regimen of oral misoprostol in Papua New Guinean women undergoing IOL. METHODS: As part of a prospective dose escalation study conducted at Modilon Hospital in Papua New Guinea, women with a singleton pregnancy in cephalic presentation and an unfavourable cervix who gave written informed consent were administered oral misoprostol, commencing at 25mcg once every 2 h for 4 doses and increased to 50mcg once every 2 h for 8 doses within 24 h...
September 8, 2017: BMC Pregnancy and Childbirth
keyword
keyword
104339
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"