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Oxytocin dosing

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https://www.readbyqxmd.com/read/29754970/cessation-of-breastfeeding-in-association-with-oxytocin-administration-and-type-of-birth-a-prospective-cohort-study
#1
Aurora Fernández-Cañadas Morillo, Modesto Durán Duque, Ana B Hernández López, Cristina Muriel Miguel, Pilar Pérez Riveiro, Angel Salcedo Mariña, Ana Royuela Vicente, María L Casillas Santana, Miguel A Marín Gabriel
BACKGROUND: Some studies have suggested an association between synthetic oxytocin administration and type of birth with the initiation and consolidation of breastfeeding. AIM: This study aimed to test whether oxytocin administration and type of birth are associated with cessation of exclusive breastfeeding at different periods. A second objective was to investigate whether the administered oxytocin dose is associated with cessation of exclusive breastfeeding. METHODS: We conducted a prospective cohort study (n=529) in a tertiary hospital...
May 10, 2018: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29750971/saliva-oxytocin-measures-do-not-reflect-peripheral-plasma-concentrations-after-intranasal-oxytocin-administration-in-men
#2
Daniel S Quintana, Lars T Westlye, Knut T Smerud, Ramy A Mahmoud, Ole A Andreassen, Per G Djupesland
Oxytocin plays an important role in social behavior. Thus, there has been significant research interest for the role of the oxytocin system in several psychiatric disorders, and the potential of intranasal oxytocin administration to treat social dysfunction. Measurement of oxytocin concentrations in saliva are sometimes used to approximate peripheral levels of oxytocin; however, the validity of the approach is unclear. In this study, saliva and plasma oxytocin was assessed after two doses of Exhalation Delivery System delivered intranasal oxytocin (8 IU and 24 IU), intravenous oxytocin (1 IU) and placebo in a double-dummy, within-subjects design with men...
May 8, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29742660/management-of-labor-and-delivery-after-fetoscopic-repair-of-an-open-neural-tube-defect
#3
Jaden R Kohn, Vibha Rao, Allison A Sellner, Dina Sharhan, Jimmy Espinoza, Alireza A Shamshirsaz, William E Whitehead, Michael A Belfort, Magdalena Sanz Cortes
OBJECTIVE: To report labor, delivery, and neonatal outcomes in a cohort of women delivering neonates who had undergone fetoscopic neural tube defect repair. METHODS: We conducted a retrospective cohort study from April 2014 to January 2018. All patients met Management of Myelomeningocele Study eligibility criteria. We included patients with completed second-trimester fetoscopic neural tube defect repair (laparotomy, uterine exteriorization, and minimally invasive access through two or three uterine ports) followed by standardized management of labor and delivery at our institution...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29715598/administration-of-oxytocin-during-spontaneous-labour-a-national-vignette-based-study-among-midwives
#4
Johanne Isidore, Anne Rousseau
OBJECTIVE: (1) to assess variations in oxytocin use by midwives during spontaneous labour (indication, dose, moment), and (2) to identify factors potentially associated with oxytocin administration. DESIGN: descriptive cross-sectional study using a case-vignette and questionnaire among French midwives from November 2015 to May 2016. METHODS: Midwives were asked to complete an online survey including a case-vignette with hourly partograms of a slowly progressing labour, and a short self-administered questionnaire...
April 21, 2018: Midwifery
https://www.readbyqxmd.com/read/29701247/does-perinatal-exposure-to-exogenous-oxytocin-influence-child-behavioural-problems-and-autistic-like-behaviours-to-20-years-of-age
#5
A J Guastella, M N Cooper, C R H White, M K White, C E Pennell, A J O Whitehouse
BACKGROUND: The neuropeptide and hormone oxytocin is known to have a significant impact on social cognition and behaviour in humans. There is growing concern regarding the influence of exogenous oxytocin (OT) administration in early life on later social and emotional development, including autism spectrum disorder (ASD). No study has examined offspring development in relation to the dose of exogenous oxytocin administered during labour. METHODS: Between 1989 and 1992, 2,900 mothers were recruited prior to the 18th week of pregnancy, delivering 2,868 live offspring...
April 27, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29693726/uterotonic-agents-for-preventing-postpartum-haemorrhage-a-network-meta-analysis
#6
REVIEW
Ioannis D Gallos, Helen M Williams, Malcolm J Price, Abi Merriel, Harold Gee, David Lissauer, Vidhya Moorthy, Aurelio Tobias, Jonathan J Deeks, Mariana Widmer, Özge Tunçalp, Ahmet Metin Gülmezoglu, G Justus Hofmeyr, Arri Coomarasamy
BACKGROUND: Postpartum haemorrhage (PPH) is the leading cause of maternal mortality worldwide. Prophylactic uterotonic drugs can prevent PPH, and are routinely recommended. There are several uterotonic drugs for preventing PPH but it is still debatable which drug is best. OBJECTIVES: To identify the most effective uterotonic drug(s) to prevent PPH, and generate a ranking according to their effectiveness and side-effect profile. SEARCH METHODS: We searched Cochrane Pregnancy and Childbirth's Trials Register (1 June 2015), ClinicalTrials...
April 25, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29662276/comparison-between-use-of-oral-misoprostol-versus-vaginal-misoprostol-for-induction-of-labour-at-term
#7
Prameela, Kavya D Sharma
Background and Objective: In modern obstetrics, around 30% of cases require induction of labour for various reasons. Misoprostol is gaining popularity as pharmacological inducing agent, though the route and dosage of administration are not standardised. The objective of the study is to compare the safety and efficacy of the two routes of misoprostol administration-oral (100 μg 4th hourly) and vaginal (25 μg 4th hourly), for induction of labour at term. Methods: In this randomised trial, 104 women having crossed the expected date of delivery without going into spontaneous labour and cases which had premature rupture of membranes <12 h were considered for labour induction and were divided into two equal groups...
April 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29657870/is-the-serum-oxytocin-level-altered-by-treatment-in-rheumatoid-arthritis-patients-complicated-with-depression
#8
Yusuke Miwa, Hidekazu Furuya, Ryo Yanai, Tsuyoshi Kasama, Kenji Sanada
Objective: The objective of this study was to investigate the factors associated with depression, including serum oxytocin (OXT) levels, disease activity, activities of daily living (ADL), and quality of life (QOL), and their effects on rheumatoid arthritis (RA). Methods: This study included 42 RA patients who received treatment with a biological agent. We measured the following variables before and after 6 months of treatment: baseline characteristics, including age, sex, disease duration, smoking, and body mass index (BMI); prednisolone and methotrexate dose; serum level of matrix metalloproteinase-3 (MMP-3); erythrocyte sedimentation rate (ESR); and C-reactive protein (CRP) level...
March 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29626416/effects-of-increased-frequency-high-dose-and-pulsatile-oxytocin-regimens-on-abnormal-labor-delivery
#9
Jiuying Liu, Yang Yi, Xu Weiwei
BACKGROUND The current guideline for oxytocin regimens in the abnormal labor of delivery is continuous infusion. The objective of the present study was to compare effects and safety measures of various available regimens of oxytocin in abnormal labor delivery. MATERIAL AND METHODS In this clinical experimental study, a total of 900 pregnant women admitted for delivery were randomized into 5 group with 162 each. Pregnant women received oxytocin as continuous administration of 16 mU/min (Group I), 1 mU/min (group II), 4 mU/min (group III), 5 mU/min quarter-hourly (group IV), and through a syringe pump (group V)...
April 7, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29614276/induction-of-labor-using-one-dose-versus-multiple-doses-of-misoprostol-a-randomized-controlled-trial
#10
Verónica Maria Pimentel, Moona Arabkhazaeli, Jee-Young Moon, Alexander Wang, Arisa Kapedani, Peter S Bernstein, Pamela J Tropper
BACKGROUND: Misoprostol is a common agent used to ripen the cervix and induce labor, yet there is no clear evidence of the optimal number of doses needed to achieve a higher rate of vaginal delivery. OBJECTIVE: Our primary objective was to compare the rate of vaginal delivery within 24 hours between a one-dose and a multiple-dose regimen of misoprostol for induction of labor STUDY DESIGN: A randomized controlled trial was conducted from March 2016 to March 2017 comparing a single dose to up to four doses of misoprostol...
March 31, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29613940/enhancing-placebo-effects-in-somatic-symptoms-through-oxytocin
#11
Aleksandrina Skvortsova, Dieuwke S Veldhuijzen, Henriët Van Middendorp, Omer Van den Bergh, Andrea W M Evers
OBJECTIVE: Placebo effects relieve various somatic symptoms, but it is unclear how they can be enhanced to maximize positive treatment outcomes. Oxytocin administration may potentially enhance placebo effects, but few studies have been performed, and they have had conflicting findings. The study aim was to investigate the influence of positive verbal suggestions and oxytocin on treatment expectations and placebo effects for pain and itch. METHODS: One hundred eight female participants were allocated to one of the following four groups: (1) oxytocin with positive verbal suggestions, (2) placebo with positive verbal suggestions, (3) oxytocin without suggestions, and (4) placebo without suggestions...
May 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29587625/the-effects-of-intranasal-oxytocin-on-reward-circuitry-responses-in-children-with-autism-spectrum-disorder
#12
R K Greene, M Spanos, C Alderman, E Walsh, J Bizzell, M G Mosner, J L Kinard, G D Stuber, T Chandrasekhar, L C Politte, L Sikich, G S Dichter
BACKGROUND: Intranasal oxytocin (OT) has been shown to improve social communication functioning of individuals with autism spectrum disorder (ASD) and, thus, has received considerable interest as a potential ASD therapeutic agent. Although preclinical research indicates that OT modulates the functional output of the mesocorticolimbic dopamine system that processes rewards, no clinical brain imaging study to date has examined the effects of OT on this system using a reward processing paradigm...
March 27, 2018: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/29538098/oxytocin-administration-in-the-basolateral-and-central-nuclei-of-amygdala-moderately-suppresses-food-intake
#13
Oscar A Klockars, Anica Klockars, Allen S Levine, Pawel K Olszewski
Oxytocin (OT) at acting central nuclei decreases meal size and reduces intake of palatable sweet solutions. It remains largely unclear as to which brain sites mediate OT's effect on palatability versus energy or the combination of those aspects of consumption. Here, we expanded the search for sites that mediate anorexigenic properties of OT by focusing on two subdivisions of the amygdala, its central (CNA) and basolateral (BLA) nuclei. We injected OT directly into the BLA or CNA in rats and assessed intake of standard chow induced by energy deprivation and intake of sweet solutions in nondeprived animals...
March 13, 2018: Neuroreport
https://www.readbyqxmd.com/read/29529522/effects-of-intranasal-oxytocin-on-the-attentional-bias-to-emotional-stimuli-in-patients-with-bulimia-nervosa
#14
Youl-Ri Kim, Jin-Sup Eom, Jennie Leppanen, Monica Leslie, Janet Treasure
BACKGROUND: Bulimia nervosa (BN) is characterized by binge eating and emotional dysregulation including increased negative affectivity (anger, anxiety). The aim of this study was to examine the effect of oxytocin on attentional processes towards anger in patients with BN. METHOD: The study design consisted of a double-blind, placebo-controlled within-subject crossover, single dose experiment. Sixty-four women (31 patients with BN and 33 healthy comparisons) completed self-reported measures to evaluate emotional difficulties and were administered a single dose of intranasal oxytocin (40IU) or placebo followed by a visual probe detection task to examine attentional orienting to angry or happy faces...
March 3, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29524451/effects-of-intranasal-oxytocin-on-satiety-signaling-in-people-with-schizophrenia
#15
Kimberly R Warren, Heidi J Wehring, Fang Liu, Robert P McMahon, Shuo Chen, Charlene Chester, Deanna L Kelly
Overweight and obesity in schizophrenia are prevalent, affecting half to three-quarters of people with schizophrenia. Hyperphagia and increased meal size have also been implicated as significant contributors to the weight gain problem. Oxytocin has shown to play a role in appetite control in humans and is considered an anorexigenic peptide. This two-day, within-subjects, challenge study involved the examination of satiety after administration of 24 IU oxytocin (intranasal) vs. placebo in participants with a DSM-IV diagnosis of schizophrenia (N = 16)...
March 7, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29523035/intrapartum-synthetic-oxytocin-and-breastfeeding-a-retrospective-cohort-study
#16
Marina Gomes, Vera Trocado, Mariana Carlos-Alves, Diana Arteiro, Paula Pinheiro
Non-pulsatile oxytocin given during labour can negatively affect breastfeeding. The aim of this study was to assess whether intrapartum oxytocin administration has any effect on breastfeeding. Secondly, to assess whether some maternal or neonatal variables influence breastfeeding. A retrospective cohort study was done, comparing two groups: women exposed (n = 101) and not exposed to oxytocin (n = 100) during labour. Women with caesarean section, vacuum extraction/forceps, twin pregnancy, breech presentation, premature neonates and with an Apgar score <7 at 5 minutes were excluded...
March 9, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29494953/to-mirror-or-not-to-mirror-upon-mutual-gaze-oxytocin-can-pave-the-way-a-cross-over-randomized-placebo-controlled-trial
#17
Jellina Prinsen, Stephanie Brams, Kaat Alaerts
The eyes constitute a highly salient cue to communicate social intent. Previous research showed that direct eye contact between two individuals can readily evoke an increased propensity to 'mirror' other peoples' actions. Considering the implicated role of the prosocial neuropeptide oxytocin (OXT) in enhancing the saliency of social cues and modulating approach/avoidance motivational tendencies, the current study adopted the non-invasive brain stimulation technique transcranial magnetic stimulation (TMS) to explore whether a single dose of intranasal OXT (24 IU) modulated (enhanced) a person's propensity to show heightened mirroring or motor resonance upon salient social cues, such as eye contact...
April 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29489527/implementation-of-an-oxytocin-checklist-to-improve-clinical-outcomes
#18
Courtney Sundin, Lauren Mazac, Kathleen Ellis, Candon Garbo
BACKGROUND: Oxytocin is one of the most common drugs administered in obstetrics. Since its designation as a high-alert medication by the Institute for Safe Medication Practices in 2007, there has been much attention to oxytocin administration during labor. Oxytocin is generally safe when administered correctly, but adverse perinatal outcomes can occur during uterine tachysystole. PURPOSE: The purpose of this project was to evaluate and compare results of maternal and fetal outcomes of induction of labor for women at term prior to and after implementation of a newly developed oxytocin checklist...
May 2018: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/29486321/oxytocin-attenuates-trust-as-a-subset-of-more-general-reinforcement-learning-with-altered-reward-circuit-functional-connectivity-in-males
#19
Jaime S Ide, Sanja Nedic, Kin F Wong, Shmuel L Strey, Elizabeth A Lawson, Bradford C Dickerson, Lawrence L Wald, Giancarlo La Camera, Lilianne R Mujica-Parodi
Oxytocin (OT) is an endogenous neuropeptide that, while originally thought to promote trust, has more recently been found to be context-dependent. Here we extend experimental paradigms previously restricted to de novo decision-to-trust, to a more realistic environment in which social relationships evolve in response to iterative feedback over twenty interactions. In a randomized, double blind, placebo-controlled within-subject/crossover experiment of human adult males, we investigated the effects of a single dose of intranasal OT (40 IU) on Bayesian expectation updating and reinforcement learning within a social context, with associated brain circuit dynamics...
July 1, 2018: NeuroImage
https://www.readbyqxmd.com/read/29480934/a-systematic-review-and-quantitative-meta-analysis-of-oxytocin-s-effects-on-feeding
#20
REVIEW
Monica Leslie, Paulo Silva, Yannis Paloyelis, James Blevins, Janet Treasure
PURPOSE: Oxytocin's anorexigenic effects have been widely documented and accepted; however, no paper has yet used the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines to compile previous findings in a single systematic review and quantitative meta-analysis. The current paper aimed to identify published and unpublished studies examining the effects of oxytocin on energy intake in animals and humans, and the factors that moderate this effect. METHODS: Web of Science, Pub Med, and Ovid were searched for published and unpublished studies reporting the effects of oxytocin on energy intake in wild-type animals and in humans, when administered in the absence of other active drugs or surgery...
February 26, 2018: Journal of Neuroendocrinology
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