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nalbuphine

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https://www.readbyqxmd.com/read/29148888/tissue-residue-levels-after-immobilization-of-rocky-mountain-elk-cervus-elaphus-nelsoni-using-a-combination-of-nalbuphine-medetomidine-and-azaperone-antagonized-with-naltrexone-atipamezole-and-tolazoline
#1
Lisa L Wolfe, Pauline Nol, Matthew P McCollum, Travis Mays, Morgan E Wehtje, William R Lance, Mark C Fisher, Michael W Miller
Previous studies demonstrated that nalbuphine, medetomidine, and azaperone (NalMed-A) can effectively immobilize adult elk (Cervus elaphus nelsoni), and be antagonized using naltrexone and atipamezole, with or without tolazoline. To assess duration of tissue residues for this immobilization package, we immobilized 14 captive adult elk with NalMed-A, then euthanized animals and collected tissues 0, 3, 6, 14, 21, or 28 d later. Except for two animals euthanized immediately, all elk were recovered using naltrexone, atipamezole, and tolazoline...
November 17, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29042911/nalbuphine-analgesic-and-anti-inflammatory-effects-on-patients-undergoing-thoracoscopic-lobectomy-during-the-perioperative-period
#2
Yang Zhang, Qi Jiang, Tao Li
This study sought to investigate the analgesic effects of nalbuphine on patients undergoing thoracoscopic lobectomy during the perioperative period, as well as its effects on inflammatory cytokines. We selected 92 patients with early lung cancer who were admitted to Xiangyang No. 1 People's Hospital between January 2016 and December 2016. The patients were randomly divided into control and observation groups (n=46 each). All patients underwent thoracoscopic lobectomy, with those in the observation group receiving intravenous nalbuphine hydrochloride prior to induction (the control group received saline)...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28928572/comparison-of-bupivacaine-plus-magnesium-sulfate-and-ropivacaine-plus-magnesium-sulfate-infiltration-for-postoperative-analgesia-in-patients-undergoing-lumbar-laminectomy-a-randomized-double-blinded-study
#3
Rajib Hazarika, Samit Parua, Dipika Choudhury, Rajesh Kumar Barooah
AIM: The objective of this study was to assess and compare the analgesic duration of local infiltration of bupivacaine plus magnesium sulfate and ropivacaine plus magnesium sulfate for postoperative analgesia in patients undergoing lumbar laminectomy. STUDY DESIGN: A randomized, prospective, double-blinded single hospital, comparative study. METHODS: Sixty adult patients of the American Society of Anesthesiologists physical Status I and II were randomly allocated into two Groups BM and RM, comprising 30 and 31 patients...
July 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28903824/pharmacokinetic-profiles-of-nalbuphine-after-intraperitoneal-and-subcutaneous-administration-to-c57bl-6-mice
#4
Brenda L Kick, Pan Shu, Bo Wen, Duxin Sun, Douglas K Taylor
Mice undergo a variety of procedures that necessitate the use of analgesic agents. Opioids are often essential to successful pain management plans, but most are controlled substances, and their use requires appropriate federal and state registrations. Nalbuphine is a potentially effective opioid analgesic for mice that is not currently classified as a controlled substance. This compound has received little attention as an analgesic for mice, and standard dosage regimens have not been developed. Here we compared the pharmacokinetic profiles of 10 mg/kg nalbuphine in male C57BL/6 mice subcutaneous or intraperitoneal administration...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28893017/a-comparative-study-of-analgesic-effect-of-intrathecal-nalbuphine-and-fentanyl-as-adjuvant-in-lower-limb-orthopaedic-surgery
#5
Shagufta Naaz, Usha Shukla, Swati Srivastava, Erum Ozair, Adil Asghar
INTRODUCTION: Intrathecal opioids when added to local anaesthetics decrease their dosage and provide haemodynamic stability. Nalbuphine is an agonist-antagonist and acts on kappa receptors providing analgesia. AIM: The study aims to compare the analgesic efficacy of fentanyl with that of two doses of nalbuphine when used with injection bupivacaine heavy in spinal anaesthesia. MATERIALS AND METHODS: A randomised, double blinded, prospective study on 90 patients of ASA I and II undergoing lower limb orthopaedic surgery under subarachnoid block was done...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28741675/pharmacokinetics-of-dinalbuphine-sebacate-and-nalbuphine-in-human-after-intramuscular-injection-of-dinalbuphine-sebacate-in-an-extended-release-formulation
#6
Yu En Tien, Wen-Chuan Huang, Hui-Yuan Kuo, Lily Tai, Yow-Shieng Uang, Wendy H Chern, Jin-Ding Huang
Nalbuphine is a semi-synthetic opioid indicated for the relief of moderate to severe pain. Its short half-life requires frequent injections in clinical practice, resulting in a greater incidence of adverse events. A prodrug of nalbuphine has been developed, dinalbuphine sebacate (DNS), dissolved in a simple oil-based injectable formulation, which could deliver and maintain an effective blood level of nalbuphine. An open-label, prospective, two-period study was performed in healthy volunteers to verify the extended blood concentration profile of nalbuphine...
July 25, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28663615/randomized-controlled-trial-for-evaluating-the-analgesic-effect-of-nalbuphine-as-an-adjuvant-to-bupivacaine-in-supraclavicular-block-under-ultrasound-guidance
#7
Nazia Nazir, Shruti Jain
INTRODUCTION: Benefits of regional anesthesia can be prolonged by adding adjuvants to local anesthetics. This study was designed to test the efficacy of adding nalbuphine to bupivacaine in supraclavicular brachial plexus blockade using ultrasound (US) guidance. METHODOLOGY: This was a prospective, randomized, double-blind study involving sixty patients of either sex undergoing elective orthopedic procedures of upper limb. In control Group C (n = 30), 30 mL of 0...
April 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28560121/comparison-of-different-analgesia-drug-regimens-for-pain-control-during-extracorporeal-shock-wave-lithotripsy-for-renal-stones-a-randomized-control-study
#8
Muhammad Waqas, Amna Butt, Mohammad Ayaz Khan, Ijaz Khan, Imad-Ud-Din Saqib, Tariq Hussain, Saeed Akhter
INTRODUCTION: With the increased use of extracorporeal shock wave lithotripsy (ESWL), the management of urolithiasis has become much convenient for the patients and the health care professionals alike. However, associated with the procedure is the common complaint of pain. No agreed upon pain management strategy has yet been developed for the procedure. We compared the effect of different analgesia drug regiments for pain control. METHODOLOGY: A randomised controlled trial was carried out in Shifa International Hospital from between July 2015 to January 2016...
April 26, 2017: Curēus
https://www.readbyqxmd.com/read/28536837/controlled-sedation-with-midazolam-and-analgesia-with-nalbuphine-to-alleviate-pain-in-patients-undergoing-subcutaneous-implantable-cardioverter-defibrillator-implantation
#9
Michaël Peyrol, Jérémie Barraud, Jennifer Cautela, Baptiste Maille, Marc Laine, Laurent Bonello, Franck Thuny, Franck Paganelli, Frédéric Franceschi, Linda Koutbi, Samuel Levy
PURPOSE: Subcutaneous implantable cardioverter defibrillator (S-ICD) is an alternative to transvenous ICD to prevent sudden cardiac death. Subcutaneous ICD implantation frequently requires general anesthesia because of procedure nociceptive steps during creation of a large device pocket and lead tunneling. This study aims to determine if a strategy of operator-guided controlled sedation with midazolam and analgesia with nalbuphine is effective in alleviating pain during S-ICD implantation...
August 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28429311/improving-animal-welfare-using-continuous-nalbuphine-infusion-in-a-long-term-rat-model-of-sepsis
#10
Victor Jeger, Mattia Arrigo, Florian F Hildenbrand, Daniel Müller, Paulin Jirkof, Till Hauffe, Burkhardt Seifert, Margarete Arras, Donat R Spahn, Dominique Bettex, Alain Rudiger
BACKGROUND: Sepsis research relies on animal models to investigate the mechanisms of the dysregulated host response to infection. Animal welfare concerns request the use of potent analgesics for the Refinement of existing sepsis models, according to the 3Rs principle. Nevertheless, adequate analgesia is often missing, partly because the effects of analgesics in this particular condition are unknown. We evaluated the use of nalbuphine, an opioid with kappa agonistic and mu antagonistic effects, in rats with and without experimental sepsis...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28367289/comparison-of-single-dose-nalbuphine-versus-tramadol-for-postoperative-pain-management-in-children-a-randomized-controlled-trial
#11
Naeem Liaqat, Sajid Hameed Dar
BACKGROUND: Acute postoperative pain control in children is an essential component of postoperative care, particularly in daycare procedures. Giving patients continuous narcotic analgesics can be risky; however, a single dose may be sufficient. METHODS: This study used a prospective, randomized controlled design and was conducted at the Pediatric Surgery Unit, Services Hospital, Lahore. In total, 150 patients who underwent inguinal herniotomy (age range: 1-12 years) were randomly assigned to two groups: group A (nalbuphine) and group B (tramadol)...
April 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28298776/a-comparative-study-for-post-operative-analgesia-in-the-emergency-laparotomies-thoracic-epidural-ropivacaine-with-nalbuphine-and-ropivacaine-with-butorphanol
#12
Saravana Babu, Bikram Kumar Gupta, Gyanendra Kumar Gautam
BACKGROUND: Adequate postoperative pain therapy for emergency abdominal surgeries is important far beyond the perioperative period because sensitization to painful stimuli can cause postoperative morbidity. A prospective, double-blind, randomized study was carried out to compare the quality of postoperative analgesia and side-effect profile between epidurally administered butorphanol and nalbuphine as an adjuvant to 0.2% ropivacaine. MATERIALS AND METHODS: A total of eighty patients, 43 men and 37 women between the age of 18 and 65 years of American Society of Anesthesiologists (ASA) Class I E and II E, who underwent intestinal perforation repair surgery were randomly allocated into two groups ropivacaine with butorphanol (RB) and ropivacaine with nalbuphine (RN), comprising of 40 patients each...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28298754/perineural-nalbuphine-in-ambulatory-upper-limb-surgery-a-comparison-of-effects-of-levobupivacaine-with-and-without-nalbuphine-as-adjuvant-in-supraclavicular-brachial-plexus-block-a-prospective-double-blinded-randomized-controlled-study
#13
Anjan Das, Sandip RoyBasunia, Anindya Mukherjee, Hirak Biswas, Rajasree Biswas, Tapobrata Mitra, Surajit Chattopadhyay, Subrata Kumar Mandal
BACKGROUND AND AIMS: Various opioid additives have been trialed to prolong brachial plexus block. We evaluated the effect of adding nalbuphine hydrochloride to levobupivacaine for supraclavicular brachial plexus blockade. The primary end-points were the onset and duration of sensory and motor blocks and duration of analgesia. MATERIALS AND METHODS: Seventy-eight patients (aged 25-45 years) posted for ambulatory forearm and hand surgery under supraclavicular brachial plexus block were divided into two equal groups (Groups LN and LC) in a randomized, double-blind fashion...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28216706/monitored-anaesthesia-care-comparison-of-nalbuphine-dexmedetomidine-versus-nalbuphine-propofol-for-middle-ear-surgeries-a-double-blind-randomised-trial
#14
Srinivasa Rao Nallam, Sunil Chiruvella, Anjineswar Reddy
BACKGROUND AND AIMS: Middle ear surgeries (MESs) are usually performed under sedation with local anaesthesia and can be well tolerated by the patient with minimal discomfort. In the present study, we compare the effect of nalbuphine/dexmedetomidine combination with nalbuphine/propofol on sedation and analgesia in monitored anaesthesia care. METHODS: One hundred adult patients undergoing MESs under monitored anaesthesia care (MAC) were randomly allocated into two groups...
January 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28051569/the-efficacy-of-nalbuphine-medetomidine-and-azaperone-in-immobilizing-american-bison-bison-bison
#15
Lisa L Wolfe, Mary E Wood, Pauline Nol, Matthew P McCollum, Mark C Fisher, William R Lance
We evaluated a combination of nalbuphine, medetomidine, and azaperone (NalMed-A) in 12 American bison ( Bison bison ) during 13 sedation handling events. The mean (SE) dosage was 0.4 (0.02) mg/kg nalbuphine, 0.08 (0.003) mg/kg medetomidine, and 0.08 (0.003) mg/kg azaperone contained in an average delivery volume of 0.8 mL/100 kg. Two animals required a supplemental dose for safe handling (additive dose used in calculating means) and a third animal was not adequately sedated despite a supplemental dose. Bison immobilized with NalMed-A showed good sedation in 12 of 13 handling attempts...
April 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28012310/physico-chemical-profiling-of-semisynthetic-opioids
#16
Károly Mazák, Sándor Hosztafi, Márta Kraszni, Béla Noszál
Species-specific acid-base and partition equilibrium constants were experimentally determined for the therapeutically important semisynthetic opioid receptor agonist hydromorphone, dihydromorphine, and mixed agonist-antagonist nalorphine and nalbuphine. The acid-base microequilibria were characterized by combining pH-potentiometry and deductive methods using synthesized auxiliary compounds. Independent of the pH, there are approximately 4.8 times as many zwitterionic microspecies than non-charged ones in nalbuphine solutions, while for nalorphine it is the non-charged form that predominates by the same ratio...
February 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27906936/analgesic-effect-of-nalbuphine-when-added-to-intravenous-regional-anesthesia-a-randomized-control-trial
#17
RANDOMIZED CONTROLLED TRIAL
Mohamed Hassan Bakri, Eman Ahmed Ismail, Sayed Kaoud Abd-Elshafy
BACKGROUND: Different adjuvant drugs are currently added to lidocaine for intravenous regional anesthesia (IVRA) to decrease tourniquet and postoperative pain. OBJECTIVE: The aim of the study was to examine the effect of nalbuphine when added toIVRA. STUDY DESIGN: Prospective, randomized, double-blind, controlled clinical trial. SETTING: Assiut University Hospitals. METHODS: One hundred-six adult patients scheduled for unilateral hand surgery under IVRA were randomized into 2 equal groups...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27850773/1136-nalbuphine-reduces-opioid-associated-urinary-retention
#18
Amy Clevenger, Christian Carr, Pamela Reiter
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27625488/factors-affecting-recovery-of-postoperative-bowel-function-after-pediatric-laparoscopic-surgery
#19
Daphnée Michelet, Juliette Andreu-Gallien, Alia Skhiri, Arnaud Bonnard, Yves Nivoche, Souhayl Dahmani
BACKGROUND AND AIMS: Laparoscopic pediatric surgery allows a rapid postoperative rehabilitation and hospital discharge. However, the optimal postoperative pain management preserving advantages of this surgical technique remains to be determined. This study aimed to identify factors affecting the postoperative recovery of bowel function after laparoscopic surgery in children. MATERIAL AND METHODS: A retrospective analysis of factors affecting recovery of bowel function in children and infants undergoing laparoscopic surgery between January 1, 2009 and September 30, 2009, was performed...
July 2016: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/27504867/efficacy-of-full-%C3%A2%C2%B5-opioid-receptor-agonists-is-not-impaired-by-concomitant-buprenorphine-or-mixed-opioid-agonists-antagonists-preclinical-and-clinical-evidence
#20
REVIEW
J C G van Niel, J Schneider, T M Tzschentke
Buprenorphine and the mixed agonists/antagonists nalbuphine and pentazocine, formerly classified as µ-opioid (MOP) receptor antagonists, have more recently been shown to be partial to full agonists of the human MOP receptor. These receptors do not necessarily have to be maximally activated for a full physiological response. Partial agonists can also sufficiently stimulate signaling processes leading to a full analgesic response, as shown by the effectiveness of buprenorphine, nalbuphine and pentazocine in animal pain models and in clinical settings where these drugs induce analgesia with full efficacy without a ceiling effect...
November 2016: Drug Research
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