Lara A Dunn, Eric J Sherman, Shrujal S Baxi, Vatche Tchekmedyian, Ravinder K Grewal, Steven M Larson, Keith S Pentlow, Sofia Haque, R Michael Tuttle, Mona M Sabra, Stephanie Fish, Laura Boucai, Jamie Walters, Ronald A Ghossein, Venkatraman E Seshan, Ai Ni, Duan Li, Jeffrey A Knauf, David G Pfister, James A Fagin, Alan L Ho
CONTEXT: BRAFV600E mutant thyroid cancers are often refractory to radioiodine (RAI). OBJECTIVES: To investigate the utility and molecular underpinnings of enhancing lesional iodide uptake with the BRAF inhibitor vemurafenib in patients with RAI-refractory (RAIR). DESIGN: This was a pilot trial that enrolled from June 2014 to January 2016. SETTING: Academic cancer center. PATIENTS: Patients with RAIR, BRAF mutant thyroid cancer...
May 1, 2019: Journal of Clinical Endocrinology and Metabolism