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C 11 Methionine

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https://www.readbyqxmd.com/read/28441858/-development-of-an-eosinophilic-bronchitis-mouse-model-and-the-effects-of-eosinophil-activation-on-airway-hyperresponsiveness-in-eosinophilic-bronchitis-mice
#1
L Li, J T Lin
Objective: To develop a mouse model of eosinophilic bronchitis, and explore the effects of eosinophil activation on airway hyperresponsiveness. Methods: A total of 60 female specific pathogen free BALB/c female mice were divided randomly into four groups: polymyxin B group, normal saline group, polymyxin B+ N-methionine leucine phenylalanine (fMLP) group, normal saline+ fMLP group. All the groups were given corresponding nasal drops for 21 days. The former two groups were given 12 μl 0.5% polymyxin B or normal saline once a day by transnasal administration respectively...
April 25, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28421396/-11-c-methionine-pet-ct-findings-in-benign-brain-disease
#2
REVIEW
Reiko Nakajima, Ken Kimura, Koichiro Abe, Shuji Sakai
(11)C-methionine (MET) is one of the most commonly used positron emission tomography (PET) tracers for evaluation of malignant brain tumor, with MET-PET being a sensitive technique for visualization of primary and recurrent malignant brain tumors. However, previous reports have demonstrated MET uptake in lesions associated with benign brain diseases. These diseases usually show an increase in MET uptake similar to that of malignant tumors. This pitfall in MET-PET image interpretation is important not only for nuclear medicine professionals, but also for radiologists...
April 18, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28416018/detection-of-histone-h3-mutations-in-cerebrospinal-fluid-derived-tumor-dna-from-children-with-diffuse-midline-glioma
#3
Tina Y Huang, Andrea Piunti, Rishi R Lulla, Jin Qi, Craig M Horbinski, Tadanori Tomita, C David James, Ali Shilatifard, Amanda M Saratsis
Diffuse midline gliomas (including diffuse intrinsic pontine glioma, DIPG) are highly morbid glial neoplasms of the thalamus or brainstem that typically arise in young children and are not surgically resectable. These tumors are characterized by a high rate of histone H3 mutation, resulting in replacement of lysine 27 with methionine (K27M) in genes encoding H3 variants H3.3 (H3F3A) and H3.1 (HIST1H3B). Detection of these gain-of-function mutations has clinical utility, as they are associated with distinct tumor biology and clinical outcomes...
April 17, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28404944/recombinant-methioninase-effectively-targets-a-ewing-s-sarcoma-in-a-patient-derived-orthotopic-xenograft-pdox-nude-mouse-model
#4
Takashi Murakami, Shukuan Li, Qinghong Han, Yuying Tan, Tasuku Kiyuna, Kentaro Igarashi, Kei Kawaguchi, Ho Kyoung Hwang, Kentaro Miyake, Arun S Singh, Scott D Nelson, Sarah M Dry, Yunfeng Li, Yukihiko Hiroshima, Thinzar M Lwin, Jonathan C DeLong, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Fritz C Eilber, Robert M Hoffman
Methionine dependence is due to the overuse of methionine for aberrant transmethylation reactions in cancer. Methionine dependence may be the only general metabolic defect in cancer. In order to exploit methionine dependence for therapy, our laboratory previously cloned L-methionine α-deamino-γ-mercaptomethane lyase [EC 4.4.1.11]). The cloned methioninase, termed recombinant methioninase, or rMETase, has been tested in mouse models of human cancer cell lines. Ewing's sarcoma is recalcitrant disease even though development of multimodal therapy has improved patients'outcome...
March 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28387066/calcifying-pseudoneoplasm-of-the-neuraxis-in-direct-continuity-with-a-low-grade-glioma-a-case-report-and-review-of-the-literature
#5
Nayuta Higa, Hideaki Yokoo, Hirofumi Hirano, Hajime Yonezawa, Tatsuki Oyoshi, Yuko Goto, Kazunori Arita
Calcifying pseudoneoplasms of the neuraxis (CAPNON) are presumed to be a non-neoplastic reactive pathology, based on the frequent finding of granulomatous inflammation. To our knowledge, there are few reports of CAPNON in association with a neoplasm. Here, we report the case of a 62-year-old man presenting with headache, which was caused by CAPNON in the left cingulate gyrus. CT scan revealed a calcified mass exhibiting gradual growth and increasing peritumoral edema. MRI showed an intra-axial hypointense mass on T1- and T2-weighted images...
April 7, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28318368/the-wayward-methyl-group-and-the-cascade-to-cancer
#6
Robert M Hoffman
We propose here a hypothesis of the cause of cancer that brings together fundamental changes in methyl-group metabolism resulting in methionine dependence and global DNA hypomethylation which destabilizes the genome leading to aneuploid karyotypes which evolve and stabilize into autonomous cancer. Experimental support for this hypothesis is that methioine dependence is a general metabolic defect in caner. Methionine dependence is due to excess use of methionene for aberrant transmethylation reactions that apparently divert methyl groups from DNA...
March 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28284101/relationship-between-14-c-meaib-uptake-and-amino-acid-transporter-family-gene-expression-levels-or-proliferative-activity-in-a-pilot-study-in-human-carcinoma-cells-comparison-with-3-h-methionine-uptake
#7
Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Hiroshi Yamauchi, Emi Ogawa, Hiroyuki Okudaira, Masato Kobayashi, Mitsuyoshi Yoshimoto, Naoto Shikano, Keiichi Kawai
INTRODUCTION: To clarify the difference between system A and L amino acid transport imaging in PET clinical imaging, we focused on the use of α-[N-methyl-(11)C]-methylaminoisobutyric acid ([(11)C]MeAIB), and compared it with [S-methyl-(11)C]-L-methionine ([(11)C]MET). The aim of this study was to assess the correlation of accumulation of these two radioactive amino acid analogs with expression of amino acid transporters and cell proliferative activity in carcinoma cells. METHODS: Amino acid uptake inhibitor studies were performed in four human carcinoma cells (epidermal carcinoma A431, colorectal carcinoma LS180, and lung carcinomas PC14/GL and H441/GL) using the radioisotope analogs [(3)H]MET and [(14)C]MeAIB...
January 26, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28260185/-11-c-l-methyl-methionine-dynamic-pet-ct-of-skeletal-muscle-response-to-protein-supplementation-compared-to-l-ring-13-c6-phenylalanine-infusion-with-serial-muscle-biopsy
#8
Emily J Arentson-Lantz, Isra H Saeed, Lynda A Frassetto, Umesh Masharani, Roy J Harnish, Youngho Seo, Henry F VanBrocklin, Randall A Hawkins, Carina Mari-Aparici, Miguel H Pampaloni, James Slater, Douglas Paddon-Jones, Thomas F Lang
OBJECTIVE: The objective of this study was to determine if clinical dynamic PET/CT imaging with (11)C-L-methyl-methionine ((11)C-MET) in healthy older women can provide an estimate of tissue-level post-absorptive and post-prandial skeletal muscle protein synthesis that is consistent with the more traditional method of calculating fractional synthesis rate (FSR) of muscle protein synthesis from skeletal muscle biopsies obtained during an infusion of L-[ring (13)C6] phenylalanine ((13)C6-Phe)...
May 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28251430/atrx-status-correlates-with-11%C3%A2-c-methionine-uptake-in-who-grade-ii-and-iii-gliomas-with-idh1-mutations
#9
Takahiro Ogishima, Kaoru Tamura, Daisuke Kobayashi, Motoki Inaji, Shihori Hayashi, Reina Tamura, Tadashi Nariai, Kenji Ishii, Taketoshi Maehara
Recent studies on gliomas have shown frequent alterations in the alpha-thalassemia/mental retardation syndrome X-linked gene (ATRX). This study was designed to determine whether ATRX status correlates with uptake of (11)C-methionine in WHO grades II and III gliomas. Sixty-two patients underwent (11)C-methionine positron emission tomography scans prior to histological diagnosis. The tumor-to-normal ratio (T/N) of (11)C-methionine uptake was calculated by dividing the maximum standardized uptake value (SUV) for the tumor by the mean SUV of the normal brain...
January 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28194701/an-automated-voxel-based-method-for-calculating-the-reference-value-for-a-brain-tumour-metabolic-index-using-18-f-fdg-pet-and-11-c-methionine-pet
#10
Miwako Takahashi, Tsutomu Soma, Akitake Mukasa, Keitaro Koyama, Takuya Arai, Toshimitsu Momose
OBJECTIVE: The tumour-to-normal ratio (T/N) is a representative index reflecting brain tumour activity by (18)F-fluorodeoxyglucose (FDG) and (11)C-methionine (MET) PET. We proposed a new automated method of calculating the normal reference value (N-value) for use as the denomination of T/N. This method uses voxel-based analysis of FDG- and MET-PET images. We compared the results of this method with those of the standard region-of-interest (ROI) method. METHODS: Data sets were obtained from 32 patients with newly diagnosed glioma and 13 patients with recurrent brain tumour...
April 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28185532/the-metabolites-in-peripheral-blood-mononuclear-cells-showed-greater-differences-between-patients-with-impaired-fasting-glucose-or-type-2-diabetes-and-healthy-controls-than-those-in-plasma
#11
Minjoo Kim, Minkyung Kim, Ji Yun Han, Sang-Hyun Lee, Sun Ha Jee, Jong Ho Lee
To determine differences between peripheral blood mononuclear cells and the plasma metabolites in patients with impaired fasting glucose or type 2 diabetes and healthy controls. In all, 65 nononobese patients (aged 30-70 years) with impaired fasting glucose or type 2 diabetes and 65 nonobese sex-matched healthy controls were included, and fasting peripheral blood mononuclear cell and plasma metabolomes were profiled. The diabetic or impaired fasting glucose patients showed higher circulating and peripheral blood mononuclear cell lipoprotein phospholipase A2 activities, high-sensitivity C-reactive protein and tumour necrosis factor-α than controls...
March 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28180966/an-update-on-the-role-of-pet-ct-and-pet-mri-in-ovarian-cancer
#12
REVIEW
Benjapa Khiewvan, Drew A Torigian, Sahra Emamzadehfard, Koosha Paydary, Ali Salavati, Sina Houshmand, Thomas J Werner, Abass Alavi
This review article summarizes the role of PET/CT and PET/MRI in ovarian cancer. With regard to the diagnosis of ovarian cancer, the presence of FDG uptake within the ovary of a postmenopausal woman raises the concern for ovarian cancer. Multiple studies show that FDG PET/CT can detect lymph node and distant metastasis in ovarian cancer with high accuracy and may, therefore, alter the management to obtain better clinical outcomes. Although PET/CT staging is superior for N and M staging of ovarian cancer, its role is limited for T staging...
February 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28139496/therapeutic-efficacy-of-an-elemental-diet-for-patients-with-crohn-s-disease-and-its-association-with-amino-acid-metabolism
#13
Masakazu Nakano, Keiichi Tominaga, Atsushi Hoshino, Takeshi Sugaya, Kazunari Kanke, Hideyuki Hiraishi
BACKGROUND/AIM: We investigated the association between blood amino acid concentration changes caused by elemental diet (ED) and their relationship to its therapeutic effect. PATIENTS AND METHODS: Patients with active Crohn's disease (CD) followed ED for 12 weeks. Patients not previously treated with ED were defined as new ED, and those with previous ED therapy (≥900 kcal/day) were defined as previous ED. Disease activity markers [Crohn's disease activity index (CDAI) and C-reactive protein (CRP) level], blood biochemistry test results, and plasma amino acid concentrations were measured before and after the treatment...
January 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28116231/the-use-of-amino-acid-pet-and-conventional-mri-for-monitoring-of-brain-tumor-therapy
#14
REVIEW
Norbert Galldiks, Ian Law, Whitney B Pope, Javier Arbizu, Karl-Josef Langen
Routine diagnostics and treatment monitoring of brain tumors is usually based on contrast-enhanced MRI. However, the capacity of conventional MRI to differentiate tumor tissue from posttherapeutic effects following neurosurgical resection, chemoradiation, alkylating chemotherapy, radiosurgery, and/or immunotherapy may be limited. Metabolic imaging using PET can provide relevant additional information on tumor metabolism, which allows for more accurate diagnostics especially in clinically equivocal situations...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28110346/prognostic-value-of-molecular-and-imaging-biomarkers-in-patients-with-supratentorial-glioma
#15
Egesta Lopci, Marco Riva, Laura Olivari, Fabio Raneri, Riccardo Soffietti, Arnoldo Piccardo, Alberto Bizzi, Pierina Navarria, Anna Maria Ascolese, Roberta Rudà, Bethania Fernandes, Federico Pessina, Marco Grimaldi, Matteo Simonelli, Marco Rossi, Tommaso Alfieri, Paolo Andrea Zucali, Marta Scorsetti, Lorenzo Bello, Arturo Chiti
PURPOSE: We evaluated the relationship between (11)C-methionine PET ((11)C-METH PET) findings and molecular biomarkers in patients with supratentorial glioma who underwent surgery. METHODS: A consecutive series of 109 patients with pathologically proven glioma (64 men, 45 women; median age 43 years) referred to our Institution from March 2012 to January 2015 for tumour resection and who underwent preoperative (11)C-METH PET were analysed. Semiquantitative evaluation of the (11)C-METH PET images included SUVmax, region of interest-to-normal brain SUV ratio (SUVratio) and metabolic tumour volume (MTV)...
January 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28091771/localization-of-parathyroid-adenomas-using-11-c-methionine-pet-after-prior-inconclusive-imaging
#16
Milou E Noltes, Annemieke M Coester, Anouk N A van der Horst-Schrivers, Bart Dorgelo, Liesbeth Jansen, Walter Noordzij, Clara Lemstra, Adrienne H Brouwers, Schelto Kruijff
PURPOSE: Minimally invasive parathyroidectomy (MIP) is the recommended treatment in primary hyperparathyroidism (pHPT) for which accurate preoperative localization is essential. The current imaging standard consists of cervical ultrasonography (cUS) and MIBI-SPECT/CT. (11)C-MET PET/CT has a higher resolution than MIBI-SPECT/CT. The aim of this study was to determine the diagnostic performance of (11)C-MET PET/CT after initial inconclusive or negative localization. METHODS: We performed a retrospective single center cohort study of patients with pHPT undergoing parathyroid surgery after prior negative imaging and later localization by means of (11)C-MET PET/CT between 2006 and 2014...
January 14, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28088230/relationship-between-the-uptake-of-18-f-borono-l-phenylalanine-and-l-methyl-11-c-methionine-in-head-and-neck-tumors-and-normal-organs
#17
Yoshiaki Watanabe, Hiroaki Kurihara, Jun Itami, Ryohei Sasaki, Yasuaki Arai, Kazuro Sugimura
BACKGROUND AND PURPOSE: The purpose of this study was to determine the distribution of 4-borono-2-(18)F-fluoro-phenylalanine ((18)F-BPA) and L-[methyl-(11)C] methionine ((11)C-Met) in normal organs and tumors and to evaluate the usefulness of (11)C-Met/PET in screening potential candidates for boron neutron capture therapy (BNCT). MATERIAL METHODS: Seven patients who had at least one histologically confirmed head and neck tumor were included in this study. They underwent both whole-body (18)F-BPA-PET/CT and (11)C-Met-PET/CT within a span of 6 months...
January 14, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28078638/-11-c-methionine-positron-emission-tomography-delineates-non-contrast-enhancing-tumor-regions-at-high-risk-for-recurrence-in-pediatric-high-grade-glioma
#18
John T Lucas, Nick Serrano, Hyun Kim, Xingyu Li, Scott E Snyder, Scott Hwang, Yimei Li, Chia-Ho Hua, Alberto Broniscer, Thomas E Merchant, Barry L Shulkin
We assessed the prognostic utility of (11)C-Methionine positron emission tomography (MET-PET) in pediatric high-grade glioma (HGG). Thirty-one children had 62 MET-PET studies. Segmented tumor volumes from co-registered magnetic resonance studies were assessed for concordance with MET-PET uptake using Boolean operations. The tumor volume at diagnosis and treatment failure was assessed relative to MET-PET avid volume. The prognostic impact of MET-PET-delineated non-contrast enhancing tumor (NCET) was assessed...
January 11, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27989134/stability-and-application-of-reactive-nitrogen-and-oxygen-species-induced-hemoglobin-modifications-in-dry-blood-spots-as-analyzed-by-liquid-chromatography-tandem-mass-spectrometry
#19
Hauh-Jyun Candy Chen, Chih-Huang Fan, Ya-Fen Yang
Dried blood spot (DBS) is an emerging microsampling technique for the bioanalysis of small molecules, including fatty acids, metabolites, drugs, and toxicants. DBS offers many advantages as a sample format including easy sample collection and cheap sample shipment. Hemoglobin adducts have been recognized as a suitable biomarker for monitoring chemical exposure. We previously reported that certain modified peptides in hemoglobin derived from reactive chlorine, nitrogen, and oxygen species are associated with factors including smoking, diabetes mellitus, and aging...
December 19, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27987557/brain-tumors-an-update-on-clinical-pet-research-in-gliomas
#20
REVIEW
Karl Herholz
A previous review published in 2012 demonstrated the role of clinical PET for diagnosis and management of brain tumors using mainly FDG, amino acid tracers, and (18)F-fluorothymidine. This review provides an update on clinical PET studies, most of which are motivated by prediction of prognosis and planning and monitoring of therapy in gliomas. For FDG, there has been additional evidence supporting late scanning, and combination with (13)N ammonia has yielded some promising results. Large neutral amino acid tracers have found widespread applications mostly based on (18)F-labeled compounds fluoroethyltyrosine and fluorodopa for targeting biopsies, therapy planning and monitoring, and as outcome markers in clinical trials...
January 2017: Seminars in Nuclear Medicine
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