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C 11 Methionine

Dwaipayan Dutta Gupta, Dandamudi Usharani, Shyamalava Mazumdar
Three stable copper complexes of peptides derived from the copper ion binding loop of the subunit II of cytochrome c oxidase have been prepared and characterized by various spectroscopic techniques. These stable copper complexes of peptides were found to exhibit cysteine, histidine and/or methionine ligation, which has predominant σ-contribution in the Cys-Cu charge transfer. The copper(ii) peptide complexes showed type-2 EPR spectra, which is uncommon in copper-cysteinate complexes. UV-visible spectra, Raman and EPR results support a tetragonal structure of the coordination geometry around the copper ion...
October 17, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
David M Schuster, Cristina Nanni, Stefano Fanti
Conventional imaging of prostate cancer has limitations related to the frequently indolent biology of the disease. PET is a functional imaging method that can exploit various aspects of tumor biology to enable greater detection of prostate cancer than can be provided by morphologic imaging alone. Radiotracers that are in use or under investigation for targeting salient features of prostate cancer include those directed to glucose, choline, acetate, prostate-specific membrane antigen, bombesin, and amino acids...
October 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Marco Mele, Lars Rolighed, MarieLouise Jespersen, Lars Rejnmark, Peer Christiansen
INTRODUCTION: Cancer in the parathyroid gland is rare, but parathyroid cancer is occasionally seen in relation to genetic abnormalities. Due to a limited amount of evidence, the optimal handling of these cases is not clear. Furthermore, the presence of a malignant parathyroid tumor is rarely known at the time of the initial operation; therefore, re-operations are often necessary. The aim of this study was to present the case of a patient with a previously diagnosed jaw tumor and parathyroid carcinoma that presents as a recurrence of hyperparathyroid hypercalcemia...
April 2016: International Journal of Endocrinology and Metabolism
Aleksi Tarkkonen, Eero Rissanen, Terhi Tuokkola, Laura Airas
We present a case where a 30-year-old man with a history of combined MS and Charcot-Marie-Tooth (CMT I) disease was additionally diagnosed and treated for grade II glioma (astrocytoma). Tumefactive MS and gliomas are sometimes difficult to distinguish from one another based on conventional magnetic resonance imaging (MRI). In our case, positron emission tomography (PET) scans with(11)C-methionine ((11)C-MET) and (11)C-PK11195 radioligands were performed to aid in differential diagnostics. The diagnosis was confirmed finally by brain biopsy...
September 2016: Multiple Sclerosis and related Disorders
María L Couce, Isidro Vitoria, Luís Aldámiz-Echevarría, Ana Fernández-Marmiesse, Iria Roca, Marta Llarena, Paula Sánchez-Pintos, Rosaura Leis, Alvaro Hermida
BACKGROUND: The mainstay of treating patients with phenylketonuria (PKU) is based on a Phe-restricted diet, restrictive in natural protein combined with Phe-free L-amino acid supplements and low protein foods. This PKU diet seems to reduce atherogenesis and confer protection against cardiovascular diseases but the results from the few published studies have been inconclusive. The aim of our study was to evaluate the relationship between the lipid profile and several treatment-related risk factors in patients with hyperphenylalaninaemia (HPA) in order to optimize their monitoring...
2016: Orphanet Journal of Rare Diseases
Sue Creviston Kaste, Scott E Snyder, Monika L Metzger, John T Sandlund, Scott Howard, Matthew Krasin, Barry L Shulkin
BACKGROUND: Methionine transport across plasma membranes occurs via large amino acid transporter ( LAT1), which is overexpressed in malignant cells leading to tracer accumulation within tumors. We investigated the uptake of (11)C-methionine in children and young adults newly diagnosed with Hodgkin lymphoma (HL) or non-Hodgkin lymphoma (NHL) and compared the biodistribution of (11)C-methionine PET-CTs ((11)C- METPET) to that of (18)F-FDG PET-CT ((18)F-FDGPET). METHODS & MATERIALS: Conducted under an IND, we prospectively enrolled patients with newly diagnosed HL (N = 19) and NHL (N = 2) onto the IRB-approved investigation of (11)C-METPET...
September 8, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
James T Thackeray, Jens P Bankstahl, Yong Wang, Kai C Wollert, Frank M Bengel
Acute tissue inflammation after myocardial infarction influences healing and remodeling and has been identified as a target for novel therapies. Molecular imaging holds promise for guidance of such therapies. The amino acid (11)C-methionine is a clinically approved agent which is thought to accumulate in macrophages, but not in healthy myocytes. We assessed the suitability of positron emission tomography (PET) with (11)C-methionine for imaging post-MI inflammation, from cell to mouse to man. Uptake assays demonstrated 7-fold higher (11)C-methionine uptake by polarized pro-inflammatory M1 macrophages over anti-inflammatory M2 subtypes (p<0...
2016: Theranostics
Olympia Koulouri, Narayanan Kandasamy, Andrew C Hoole, Daniel Gillett, Sarah Heard, Andrew S Powlson, Dominic G O'Donovan, Anand K Annamalai, Helen L Simpson, Scott A Akker, Simon J B Aylwin, Antonia Brooke, Harit Buch, Miles J Levy, Niamh Martin, Damian Morris, Craig Parkinson, James R Tysome, Tom Santarius, Neil Donnelly, John Buscombe, Istvan Boros, Rob Smith, Franklin Aigbirhio, Nagui M Antoun, Neil G Burnet, Heok Cheow, Richard J Mannion, John D Pickard, Mark Gurnell
OBJECTIVE: To determine if functional imaging using (11)C-methionine positron emission tomography co-registered with 3D gradient echo MRI (Met-PET/MRI), can identify sites of residual active tumour in treated acromegaly, and discriminate these from post-treatment change, to allow further targeted treatment. DESIGN/METHODS: Twenty-six patients with persistent acromegaly after previous treatment, in whom MRI appearances were considered indeterminate, were referred to our centre for further evaluation over a 4...
November 2016: European Journal of Endocrinology
Tadashi Watabe, Hayato Ikeda, Shushi Nagamori, Pattama Wiriyasermkul, Yoko Tanaka, Sadahiro Naka, Yasukazu Kanai, Kohei Hagiwara, Masanao Aoki, Eku Shimosegawa, Yoshikatsu Kanai, Jun Hatazawa
PURPOSE: The purpose of this study was to evaluate the usefulness of L-4-borono-2-(18)F-fluoro-phenylalanine ((18)F-FBPA) as a tumor-specific probe, in comparison to (18)F-FDG and (11)C-methionine (Met), focusing on its transport selectivity by L-type amino acid transporter 1 (LAT1), which is highly upregulated in cancers. METHODS: Cellular analyses of FBPA were performed to evaluate the transportablity and Km value. PET studies were performed in rat xenograft models of C6 glioma (n = 12) and in rat models of turpentine oil-induced subcutaneous inflammation (n = 9)...
August 22, 2016: European Journal of Nuclear Medicine and Molecular Imaging
Martin Krakauer, Andreas Kjaer, Finn N Bennedbæk
Preoperative localisation of the diseased parathyroid gland(s) in primary hyperparathyroidism (PHP) is a prerequisite for subsequent minimally invasive surgery. Recently, as alternatives to conventional sestamibi parathyroid scintigraphy, the (11)C-based positron emission tomography (PET) tracers methionine and choline have shown promise for this purpose. We evaluated the feasibility of using the (18)F-based PET tracer fluoroethyl-l-tyrosine (FET), as the longer half-life of (18)F makes it logistically more favourable...
August 17, 2016: Diagnostics
J R Garcia, M Cozar, M Baquero, J M Fernández Barrionuevo, A Jaramillo, J Rubio, G Maida, M Soler, E Riera
OBJECTIVE: To evaluate the contribution of (11)C-Methionine PET in the early differentiation between tumour recurrence and radionecrosis in patients treated for a high grade glioma. METHOD: The study included 30 patients with glioma (III/IV grade) treated with surgery/radiotherapy/chemotherapy (5-8 months) and with an indeterminate MRI. All patients underwent a (11)C-Methione PET (within 15 days of MRI) and studies were visually analysed (intensity and morphology of uptake), quantified (SUV max/SUV mean background), and coregistered to MRI (3D-Flair)...
August 6, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
Yoshifumi Maya, Rudolf A Werner, Claudia Schütz, Hiroshi Wakabayashi, Samuel Samnick, Constantin Lapa, Roland Jahns, Christina Zechmeister, Valérie Jahns, Takahiro Higuchi
: Myocarditis represents a major cause of dilated cardiomyopathy and sudden cardiac death in younger adults. Currently, definitive diagnosis of myocarditis requires endomyocardial biopsy, which is highly invasive and has the drawback of variable sensitivity due to inherent sampling error. Therefore, reliable non-invasive methods to detect and monitor cardiac inflammation are clinically relevant. In this study, we explored the potential of radiolabeled methionine to assess myocardial inflammatory activity in a rat model of experimental autoimmune myocarditis (EAM)...
July 7, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Emanuel Steiner, Lukas Kazianka, Robert Breuer, Marcus Hacker, Wolfgang Wadsak, Markus Mitterhauser, Thomas Stimpfl, Birgit Reiter, Georgios Karanikas, Johannes Miholic
PURPOSE: [S-methyl-(11)C]-L-methionine ([(11)C]MET) uptake in the pancreas might be a central indicator of beta cell function. Since gastric emptying was recently shown to influence glycemic control in subjects after pancreaticoduodenectomy (PD, the surgical treatment of neoplasms of the pancreas head), we looked for imaginable relationships between gastric emptying, pre- and postprandial insulin concentrations, and [(11)C]MET uptake. METHODS: Nineteen tumor-free survivors after PD (age mean ± SD: 61 ± 8...
July 7, 2016: European Journal of Nuclear Medicine and Molecular Imaging
Tae-Young Jung, Jung-Joon Min, Hee-Seung Bom, Shin Jung, In-Young Kim, Sa-Hoe Lim, Dong-Yeon Kim, Seong Young Kwon
We investigated the diagnostic and prognostic significance of metabolic parameters from (11)C-methionine (MET) positron emission tomography (PET) in patients with malignant glioma. The MET-PET was examined in 42 patients who had been previously treated with adjuvant treatment for malignant glioma. Both ratios of maximal MET uptake of the tumors to those of the contralateral normal gray matter (T/N ratio) and metabolic tumor volume (MTV) were estimated in each lesion. The diagnostic performance for recurrence was investigated in all enrolled patients...
June 10, 2016: Neurosurgical Review
Noriaki Tomura, Toshiyuiki Saginoya, Yasuaki Mizuno, Hiromi Goto
BACKGROUND: For pituitary tumors, positron emission tomography (PET) with (11)C-methonine (MET) has been reported as feasible to facilitate diagnosis. MET is well-known to accumulate in the normal pituitary glands, but almost no studies have examined the degree of MET accumulation in the normal pituitary gland. PURPOSE: To investigate accumulation of MET in normal pituitary gland on PET/CT. MATERIAL AND METHODS: Among patients who underwent PET/CT using MET over the past 7 years, 77 patients who fulfilled our criteria for normal pituitary glands were retrospectively selected...
June 6, 2016: Acta Radiologica
Gaia Grassetto, Abass Alavi, Domenico Rubello
In parathyroid disease, classical scintigraphic techniques remain the first choice for localizing hyperfunctional parathyroid glands in primary known hyperparathyroidism and in case of secondary, tertiary, and recurrent hyperparathyroidism. When classical scintigraphic techniques are not diagnostic, however, (11)C-methionine seems to offer a good imaging alternative.
July 2007: PET Clinics
Kimiteru Ito, Hiroshi Matsuda, Kazoo Kubota
(11)C-methionine (Met) positron emission tomography (PET) is one of the most commonly used PET tracers for evaluating brain tumors. However, few reports have described tips and pitfalls of (11)C-Met PET for general practitioners. Physiological (11)C-Met uptake, anatomical variations, vascular disorders, non-tumorous lesions such as inflammation or dysplasia, benign brain tumors and patient condition during (11)C-Met PET examination can potentially affect the image interpretation and cause false positives and negatives...
May 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
Ellen S Kim, Martin Satter, Marilyn Reed, Ronald Fadell, Arash Kardan
Glioblastoma multiforme (GBM) is the most common and lethal malignant glioma in adults. Currently, the modality of choice for diagnosing brain tumor is high-resolution magnetic resonance imaging (MRI) with contrast, which provides anatomic detail and localization. Studies have demonstrated, however, that MRI may have limited utility in delineating the full tumor extent precisely. Studies suggest that MR spectroscopy (MRS) can also be used to distinguish high-grade from low-grade gliomas. However, due to operator dependent variables and the heterogeneous nature of gliomas, the potential for error in diagnostic accuracy with MRS is a concern...
June 2016: Neuroradiology Journal
Rajnish Sharma, Maria D'Souza, Abhinav Jaimini, Puja Panwar Hazari, Sanjeev Saw, Santosh Pandey, Dinesh Singh, Yachna Solanki, Nitin Kumar, Anil K Mishra, Anupam Mondal
INTRODUCTION: (11)C-methonine ([(11)C]-MET) positron emission tomography-computed tomography (PET-CT) is a well-established technique for evaluation of tumor for diagnosis and treatment planning in neurooncology. [(11)C]-MET reflects amino acid transport and has been shown to be more sensitive than magnetic resonance imaging (MRI) in stereotactic biopsy planning. This study compared fluorodeoxyglucose (FDG) PET-CT and MET PET-CT in the detection of various brain tumors. MATERIALS AND METHODS: Sixty-four subjects of brain tumor treated by surgery, chemotherapy, and/or radiotherapy were subjected to [(18)F]-FDG, [(11)C]-MET, and MRI scan...
April 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Wouter P Kluijfhout, Jesse D Pasternak, Frederick Thurston Drake, Toni Beninato, Jessica E Gosnell, Wen T Shen, Quan-Yang Duh, Isabel E Allen, Menno R Vriens, Bart de Keizer, Miguel H Pampaloni, Insoo Suh
PURPOSE: The great spatial and temporal resolution of positron emission tomography might provide the answer for patients with primary hyperparathyroidism (pHPT) and non-localized parathyroid glands. We performed a systematic review of the evidence regarding all investigated tracers. METHODS: A study was considered eligible when the following criteria were met: (1) adults ≥17 years old with non-familial pHPT, (2) evaluation of at least one PET isotope, and (3) post-surgical and pathological diagnosis as the gold standard...
April 16, 2016: Langenbeck's Archives of Surgery
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