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Behcet disease

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https://www.readbyqxmd.com/read/29333411/successful-treatment-of-a-patient-with-myelodysplastic-syndrome-accompanied-by-pyoderma-gangrenosum-and-beh%C3%A3-et-s-disease-using-allogeneic-stem-cell-transplantation
#1
Seung-Shin Lee, Jae-Sook Ahn, Sook Jung Yun, Dong-Jin Park
No abstract text is available yet for this article.
December 2017: Blood Research
https://www.readbyqxmd.com/read/29332924/multiple-recurrent-pseudoaneurysms-after-endovascular-repair-of-abdominal-aortic-aneurysm-in-a-patient-with-beh%C3%A3-et-s-disease
#2
Yohei Yamamoto, Yoshinori Inoue, Tsuyoshi Ichinose, Masato Nishizawa, Kimihiro Igari, Takahiro Toyofuku, Toshifumi Kudo
In Behçet's disease (BD) patients, endovascular repair is a reasonable alternative treatment for aortic aneurysms to avoid postoperative anastomotic pseudoaneurysms. However, there are some complications that may occur after endovascular repair. We herein report the case of a 40-year-old man with active BD developed recurrent aortic pseudoaneurysms at the proximal and distal margins of the stent graft and a femoral puncture site pseudoaneurysm 3 months after endovascular abdominal aortic aneurysm (AAA) repair...
January 15, 2018: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29328521/the-central-vein-sign-differentiates-ms-from-cns-inflammatory-vasculopathies
#3
Pietro Maggi, Martina Absinta, Matteo Grammatico, Luisa Vuolo, Giacomo Emmi, Giovanna Carlucci, Gregorio Spagni, Alessandro Barilaro, Anna Maria Repice, Lorenzo Emmi, Domenico Prisco, Vittorio Martinelli, Roberta Scotti, Niloufar Sadeghi, Gaetano Perrotta, Pascal Sati, Bernard Dachy, Daniel S Reich, Massimo Filippi, Luca Massacesi
OBJECTIVES: In multiple sclerosis (MS), MRI is a sensitive tool for detecting white matter lesions, but its diagnostic specificity is still suboptimal; ambiguous cases are frequent in clinical practice. Detection of perivenular lesions in the brain (the "central vein sign") improves the pathological specificity of MS diagnosis, but comprehensive evaluation of this MRI biomarker in MS-mimicking inflammatory and/or autoimmune diseases, such as CNS inflammatory vasculopathies, is missing...
January 12, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29319272/behcet-s-disease-dilemma
#4
Ladli Chatterjee, A A Bamanikar
No abstract text is available yet for this article.
October 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29313056/generalized-purpura-as-an-atypical-skin-manifestation-of-adult-onset-still-s-disease-in-a-patient-with-beh%C3%A3-et-s-disease
#5
Chika Omigawa, Takashi Hashimoto, Takaaki Hanafusa, Takeshi Namiki, Ken Igawa, Hiroo Yokozeki
No abstract text is available yet for this article.
January 9, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29311362/novel-transcriptional-activity-and-extensive-allelic-imbalance-in-the-human-mhc-region
#6
Elizabeth Gensterblum-Miller, Weisheng Wu, Amr H Sawalha
The MHC region encodes HLA genes and is the most complex region in the human genome. The extensively polymorphic nature of the HLA hinders accurate localization and functional assessment of disease risk loci within this region. Using targeted capture sequencing and constructing individualized genomes for transcriptome alignment, we identified 908 novel transcripts within the human MHC region. These include 593 novel isoforms of known genes, 137 antisense strand RNAs, 119 novel long intergenic noncoding RNAs, and 5 transcripts of 3 novel putative protein-coding human endogenous retrovirus genes...
January 8, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29308287/rapid-loss-of-efficacy-of-biosimilar-infliximab-in-three-patients-with-beh%C3%A3-et-s-disease-after-switching-from-infliximab-originator
#7
Fabrizio Cantini, Laura Niccoli, Carlotta Nannini, Emanuele Cassarà, Olga Kaloudi
Three patients affected by Behçet's disease (BD) with severe uveitis and neurological involvement in stable clinical remission and who rapidly relapsed after switching from reference infliximab (re-IFX) to biosimilar infliximab (bio-IFX) are reported. In order to observe the rules of local health authorities, two males and one female (38, 26, and 40 years old, respectively) with BD complicated by severe uveitis and neuro-Behçet and who were in prolonged remission, were switched from re-IFX to bio-IFX, with the same dosing regimen of 5 mg/kg intravenous infusions every 8 weeks...
December 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29308279/the-real-world-use-of-different-anti-tumor-necrosis-factor-agents-in-a-northern-european-population-of-patients-with-beh%C3%A3-et-s-disease
#8
Fahd Adeeb, Wan Lin Ng, Maria Usman Khan, Joseph Devlin, Austin G Stack, Alexander Duncan Fraser
Objective: The aim of this study was to evaluate prescription practices, treatment responses, and serious adverse events of anti-tumor necrosis factor (anti-TNF) therapies in Behçet's disease (BD). Material and Methods: Patients with BD satisfying the International Study Group for Behçet's Disease or the International Criteria for Behçet's Disease criteria were recruited from a regional rheumatology program. The choice of anti-TNF, treatment response, and adverse events were specified...
December 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29308278/abo-blood-groups-and-rheumatic-diseases
#9
Songül Çildağ, Yasemin Kara, Taşkın Şentürk
Objective: Various genetic and environmental risk factors have been shown to be associated with the incidence of rheumatic diseases. However, the pathogenesis of rheumatic diseases poorly understood. Several studies have shown associations of ABO blood groups with various diseases. Our study aimed to determine whether there is an association between the types of rheumatic diseases and ABO and Rh blood groups. Material and Methods: The study included the patients, followed up at the Immunology-Rheumatology clinic between January 2016 and December 2016 for diagnosis of rheumatic disease, who had an ABO Rh blood data...
December 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29308276/beh%C3%A3-et-s-disease-in-the-united-states-a-single-center-descriptive-and-comparative-study
#10
Nathan C Kilian, Amr H Sawalha
Objective: Behçet's disease is heterogeneous with clinical variability across ethnicities and geographic locations. The goal of this study was to analyze the clinical characteristics of our multi-ethnic Behçet's disease cohort at the University of Michigan. Material and Methods: A detailed patient characterization was performed. Differences in disease characteristics between men and women, and between patients fulfilling the International Criteria for Behçet's Disease (ICBD) and the International Study Group criteria (ISG) were determined in our cohort...
December 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29296024/beh%C3%A3-et-syndrome-a-contemporary-view
#11
REVIEW
Hasan Yazici, Emire Seyahi, Gulen Hatemi, Yusuf Yazici
The presence of symptom clusters, regional differences in disease expression and similarities with, for example, Crohn's disease suggest multiple pathological pathways are involved in Behçet syndrome. These features also make formulating disease criteria difficult. Genetic studies have identified HLA-B*51 to be the important genetic risk factor. However, the low prevalence of HLA-B*51 in many patients with bone fide disease, especially in non-endemic regions, suggests other factors must also be operative in Behçet syndrome...
January 3, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29287101/cancer-risk-in-korean-patients-with-beh%C3%A3-et-s-disease-a-nationwide-population-based-study
#12
Yoon Suk Jung, Minkyung Han, Do Young Kim, Jae Hee Cheon, Sohee Park
BACKGROUND: Various immune-mediated diseases are associated with increased malignancy risks. However, the relationship between Behçet's disease (BD) and cancer remains unclear. We conducted a nationwide, population-based study to determine the risk of cancer in patients with BD. METHODS: Using National Health Insurance claims records, we collected data from 2402 patients diagnosed with BD between 2013 and 2014. Standardized incidence ratios (SIRs) of overall and site-specific cancers in patients with BD in comparison with the general population were calculated...
2017: PloS One
https://www.readbyqxmd.com/read/29285231/associations-between-tnfsf4-tnfsf8-and-tnfsf15-and-beh%C3%A3-et-s-disease-but-not-vkh-syndrome-in-han-chinese
#13
Yan Jiang, Ling Cheng, Xin Li, Wenke Zhou, Li Zhang
The present study was designed to explore the interrelationship between single nucleotide polymorphisms (SNP) of the tumor necrosis factor superfamily (TNFSF) and its respective receptor superfamily (TNFRSF) genes and Behcet's disease (BD) and Vogt-Koyanagi-Harada syndrome (VKH) in Han Chinese. The study sample included 796 patients with BD, 792 patients with VKH syndrome, and 1604 healthy controls. The genotyping of 35 SNPs was performed by MassARRAY platform (Sequenom), iPLEX Gold Assay, PCR-restriction fragment length polymorphism assay and TaqMan SNP assay...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29260026/brain-biopsy-to-aid-diagnosis-of-neuro-beh%C3%A3-et-s-disease-case-report-and-literature-review
#14
Hiroki Yamada, Kazuyuki Saito, Mitsuhiko Hokari, Shuta Toru
Central nervous system involvement in Behçet's disease (Neuro-Behçet's disease: NBD) has been reported to present diverse clinical and pathological manifestations. A few cases presenting with neurological symptoms preceding other systemic features are difficult to be diagnosed. Here we suggest the clinical benefit of brain biopsy with a case of NBD initially presenting neurological symptoms.
September 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/29245353/multiple-aneurysms-and-gastrointestinal-involvement-in-behcet-s-disease-a-case-report
#15
Mengdi Wang, Weiwei Sun, Zhenjie Chen, Xiaona Wang, Jie Lv, Quanming Tan, Yaoxian Wang, Jingwei Zhou
RATIONALE: Behcet's disease (BD) is a rare systemic vasculitis disorder that can involve vessels of any size. PATIENT CONCERNS: A 60-year-old female had recurrent painful mouth ulcers about 30 years ago and recently presented with abdominal distension, conjunctival congestion, and chest pain in sequence. DIAGNOSES: The patient was diagnosed with BD according to the International Criteria for Behcet's Disease (ICBD). INTERVENTIONS: A therapy of glucocorticoids and cyclophosphamide was administered...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29245339/ten-year-progress-of-coronary-artery-lesions-prior-to-beh%C3%A3-et-disease-diagnosis-a-case-report-and-care-compliant-article
#16
Wenfang Ma, Yan Liang, Jun Zhu
INTRODUCTION: Behçet disease is a multisystemic chronic inflammatory disorder characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. However, particularly part of patients would present cardiovascular involvements and vascular lesions could be the presenting sign of Behçet disease preceding classical symptoms. We presented a middle aged male patient, in whom abdominal aorta pseudoaneurysm was as the first leading sign to reveal Behçet disease, and with his coronary artery lesions progress through a 10-year period before Behçet disease was diagnosed...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29241760/miscellaneous-skin-disease-and-the-metabolic-syndrome
#17
Sila Seremet, Mehmet Salih Gurel
The link between the metabolic syndrome (MetS) and skin diseases is increasingly important, with new associations being discovered. The association between MetS and psoriasis or MetS and hidradenitis suppurativa is well known, although the relationship between MetS and various autoimmune or inflammatory diseases has only recently attracted interest. Some inflammatory skin diseases, such as vitiligo, scleredema, recurrent aphthous stomatitis, Behçet disease, rosacea, necrobiosis lipoidica, granuloma annulare, skin tags, knuckle pads, and eruptive xanthomas, have possible associations with MetS...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29225266/a-case-of-aortic-regurgitation-presenting-with-recurrent-detachment-of-a-prosthetic-valve-as-the-first-presenting-symptom-of-cardiovascular-beh%C3%A3-et-s-disease
#18
Tsugumi Takayama, Takuya Ozawa, Akiko Sanada, Tohru Watanabe, Masahiro Ito, Satoru Hirono, Yoshifusa Aizawa, Tohru Minamino
A 33-year-old man with severe aortic regurgitation underwent initial aortic valve replacement (AVR). During the 2 years after AVR, 3 reoperations for prosthetic valve detachment were required. During hospitalization, he had no typical clinical findings, with the exception of a persistent inflammatory reaction; a pseudo-aneurysm around the Bentall graft developed 27 days after the 4th operation. This unique clinical course suggested the possibility of Behçet's disease. In the 8 years of follow-up after the administration of prednisolone, the pseudo-aneurysm did not become enlarged and the detachment of the prosthetic valve was not observed...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29224587/the-prevalence-of-beh%C3%A3-et-s-disease-in-the-north-of-jordan-a-hospital-based-epidemiological-survey
#19
Wafa Y Madanat, Khaldoon M Alawneh, Mahmoud M Smadi, Salwa S Saadeh, Muntasser M Omari, Anas B Bani Hani, Hasan Yazici
OBJECTIVES: To estimate the prevalence of Behçet's disease (BD) in Jordan, with the additional aim of comparing this prevalence among hospital workers in other geographical areas. METHODS: In the first stage of our survey, 2,569 employees from 6 hospitals in north Jordan were interviewed using a screening questionnaire to identify individuals with recurrent oral ulcers (ROU), a previous diagnosis of BD (PDBD) and/or any major symptom related to BD. In the second stage, all individuals with ROU or PDBD identified at stage 1, were examined by 2 rheumatologists for the presence/confirmation of BD according to the International Study Group (ISG) criteria...
November 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29218258/breaking-the-magic-mouth-and-genital-ulcers-with-inflamed-cartilage-syndrome
#20
REVIEW
Stella Pak, Shaina Logemann, Christine Dee, Adam Fershko
Mouth and genital ulcers with inflamed cartilage (MAGIC) syndrome refers to a condition in which features of Behcet's disease (BD) and relapsing polychondritis (RP) occur in the same individual. The existence of MAGIC syndrome suggests a potential common etiology for BD and RP. However, connecting these two diseases and referring to this condition as MAGIC syndrome might have been premature, as there is currently insufficient knowledge on BD and RP. In this critical review, we argue that these two clinical entities could possibly be unique disease processes rather than two ends of the same disease spectrum...
October 4, 2017: Curēus
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