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Behcet disease

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https://www.readbyqxmd.com/read/28934765/qualitative-study-the-experience-and-impact-of-living-with-behcet-s-syndrome
#1
Vicky Tai, Karen Lindsay, Joanne L Sims, Fiona M McQueen
AIM: Behcet's syndrome is a rare chronic multisystemic vasculitis of unknown aetiology, is unpredictable and can cause life-threatening complications. This qualitative study aims to explore the experiences of patients living with Behcet's syndrome in New Zealand. METHODS: Eight English-speaking patients participated in in-depth semi-structured interviews about their experiences of living with Behcet's syndrome. Interviews were recorded and transcribed. Data were analysed using a general inductive thematic approach...
September 22, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28916029/oral-mucosa-biology-and-salivary-biomarkers
#2
Rosie Qin, Andrea Steel, Nasim Fazel
Although the surfaces of both the skin and oral mucosa are protected by squamous epithelial cells and fall within the scope of dermatologic practice, the oral cavity contains highly specialized structures and functions distinct from other skin biology and pathologic conditions and are also the purview of clinicians who care for patients with skin and mucosal diseases. We describe the distinct features of the tongue, mucosa, and salivary glands. In particular, we examine the composition and function of the saliva, with special focus on salivary biomarkers...
September 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28916023/beh%C3%A3-et-disease-new-aspects
#3
Isil Bulur, Meltem Onder
Behçet disease is currently considered an "autoinflammatory disease" triggered by infection and environmental factors in genetically predisposed individuals. Although the disease is characterized by recurrent oral and genital aphthous ulcers and ocular involvement, it can affect multiple organ systems. Complex aphthosis is characterized by recurrent oral and/or genital aphthous ulcers. It is important to evaluate the patient with complex aphthosis for Behçet disease and related systemic disorders. We discuss the etiopathogenesis, clinical features, diagnostic criteria, and treatment approaches for complex aphthosis and Behçet disease in light of the current literature...
September 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28913513/choroidal-thickness-in-non-ocular-beh%C3%A3-et-s-disease-a-spectral-domain-oct-study
#4
Aman Mittal, Swetha Bindu Velaga, Khalil Ghasemi Falavarjani, Muneeswar G Nittala, Srinivas R Sadda
PURPOSE: To evaluate choroidal thickness in patients with non-ocular Behçet's disease (BD) using spectral domain optical coherence tomography (SD-OCT) and to compare the results to normal eyes. METHODS: In this retrospective observational comparative study, we collected OCT and clinical data from the charts of 4 patients (7 eyes) with BD who had been referred for a screening eye exam and had a normal ocular examination. Data from 9 healthy volunteers (17 eyes) were collected as age-matched controls...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28912865/elevated-levels-of-soluble-fractalkine-and-increased-expression-of-cx3cr1-in-neuropsychiatric-systemic-lupus-erythematosus
#5
Ling Guo, Xiaoye Lu, Yuan Wang, Chunde Bao, Shunle Chen
The aim of the present study was to determine the levels of soluble fractalkine (sFKN) and expression of CX3CR1 in neuropsychiatric systemic lupus erythematosus (NPSLE). Disease activity of SLE was assessed using the SLE Disease Activity Index (SLEDAI). The mRNA expression levels of CX3CR1 and FKN were quantified using reverse transcription-quantitative polymerase chain reaction. Levels of sFKN in the serum and cerebrospinal fluid (CSF) were measured using enzyme-linked immunosorbent assays. The mRNA expression levels of CX3CR1 in peripheral blood mononuclear cells from patients with NPSLE, non-NPSLE and Behcet's disease were significantly higher than that of rheumatoid arthritis and healthy persons...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28910560/intravitreal-adalimumab-for-the-control-of-breakthrough-intraocular-inflammation
#6
Wajiha J Kheir, Carl-Joe Mehanna, Maamoun Abdul Fattah, Sara Al Ghadban, Marwan El Sabban, Ahmad M Mansour, Rola N Hamam
PURPOSE: Investigate the efficacy of intravitreal adalimumab in breakthrough panuveitis in patients on systemic adalimumab for more than 3 months. METHODS: Retrospective study of patients on systemic adalimumab with breakthrough panuveitis requiring intravitreal adalimumab therapy. RESULTS: Seven eyes of four patients with Adamantiades-Behçet disease panuveitis were included and all were maintained on systemic adalimumab for 7.3 months (range 3-11) with inflammation controlled for 4...
September 14, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28898393/is-beh%C3%A3-et-s-disease-a-class-1-opathy-the-role-of-hla-b-51-in-the-pathogenesis-of-beh%C3%A3-et-s-disease
#7
REVIEW
Mark Giza, Danai Koftori, Liye Chen, Paul Bowness
The association between carriage of the HLA-B*51 allele and development of Behçet's Disease (BD) has been known since the early 1970s, but the exact mechanisms responsible for its role in pathogenesis remain much-debated. In an effort to explain the disease process, it has been suggested that BD constitutes one of a newly-termed group of diseases, the 'MHC-I-opathies'. Other MHC-I-opathies' include Ankylosing Spondylitis and other HLA-B*27-associated spondyloarthropathies, and HLA-C*0602-associated skin psoriasis...
September 12, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28895041/unmet-needs-in-the-pathogenesis-and-treatment-of-vasculitides
#8
REVIEW
Francesco Muratore, Giulia Pazzola, Alessandra Soriano, Nicolò Pipitone, Stefania Croci, Martina Bonacini, Luigi Boiardi, Carlo Salvarani
Despite the progress in the last years on the field of vasculitides, there are several unmet needs regarding classification, disease activity assessment, predictors of flares and complications, and type of treatment for the different forms. The 1990 American College of Rheumatology (ACR) classification criteria currently used to define giant cell arteritis and Takayasu arteritis were designed to discriminate between different types of vasculitides but not to differentiate vasculitis from other disorders. Recently, efforts have been made to overcome the shortcomings of the ACR criteria...
September 11, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28883472/the-relationship-between-hematological-indices-and-autoimmune-rheumatic-diseases-ards-a-meta-analysis
#9
Xuanyu Hao, Dongyang Li, Dan Wu, Ning Zhang
This meta-analysis was undertaken to investigate the relationship between hematological indices and autoimmune rheumatic diseases (ARDs). PubMed, Embase, and Web of Science were searchedfor studies of ARDs and hematological indices. Standardized mean difference (SMD) was calculated with confidence interval (CI) of 95%. 18 studies were included in our meta-analysis. Compared to the healthy control group, neutrophil-lymphocyte ratio (NLR) was increased in patients with ankylosing spongdylitis(AS), Behçet's disease(BD), andrheumatoid arthritis(RA)(SMD = 0...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28881647/ocular-behcet-s-disease-is-associated-with-aberrant-methylation-of-interferon-regulatory-factor-8-irf8-in-monocyte-derived-dendritic-cells
#10
Yiguo Qiu, Yunyun Zhu, Hongsong Yu, Shenglan Yi, Wencheng Su, Qingfeng Cao, Gangxiang Yuan, Aize Kijlstra, Peizeng Yang
Aberrant methylation of interferon regulatory factor 8 (IRF8) has been noted in various tumors. IRF8 has also been reported to be involved in many autoimmune diseases, including Behcet's disease (BD). However, the methylation status of IRF8 in BD has not been reported. To address this issue, we investigated whether the degree of methylation of IRF8 in dendritic cells (DCs) plays a role in the development of BD. We found a lower mRNA expression and a higher methylation level of IRF8 in active ocular BD patients as compared to normal subjects and inactive patients...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28874203/behcet-s-disease-with-recurrent-thoracic-aortic-aneurysm-combined-with-femoral-artery-aneurysm-a-case-report-and-literature-review
#11
Shi-Huai Zhang, Fu-Xian Zhang
BACKGROUND: Aneurysm or pseudoaneurysm is the main vascular complication of Behcet's disease. Most hospitals adopt endovascular treatment. CASE PRESENTATION: We report a case of Behcet's disease with recurrent thoracic aortic aneurysm combined with femoral artery aneurysm. The patient underwent two rounds of endovascular surgery, but developed new aneurysms immediately after surgery. Eventually, the patient died due to rupture of recurrent aneurysm. CONCLUSIONS: For vasculo-Behcet's disease, we suggest performing the operation during the stable period...
September 6, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28869232/to-immunosuppress-or-not-behcet-s-syndrome-presenting-as-an-eosinophilic-pleural-effusion
#12
Shakti Kumar Bal, Richa Gupta, Aparna Irodi, Avinash Nair, John Mathew, Balamugesh Thangakunam, Devasahayam Jesudas Christopher
Etiologic diagnosis of an eosinophilic pleural effusion (EPE) presents a diagnostic challenge when intrapleural air and blood have been ruled out as its proximate causes. Among the causes of EPE, those that require immunosuppression for the underlying disease include connective tissue diseases, sarcoidosis, vasculitis, and eosinophilic pneumonia. We present a case of clinically suspected Behcet's syndrome based on a 10-year history of recurrent multiple oral ulcers and human leukocyte antigen-B51 positivity who presented with only an EPE...
September 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28863008/olfactory-dysfunction-associated-with-neuro-beh%C3%A3-et-disease
#13
Remzi Doğan, Burak Ertaş, Berke Özücer, Erkingul Birday, Orhan Özturan, Bayram Veyseller
INTRODUCTION: Neurologic involvement associated with Behçet disease (BD) is defined as a different entity: Neuro-Behçet disease (NBD). Behçet disease presents with olfactory dysfunction. It is not known whether this is the consequence of mucosal involvement or neurologic involvement. OBJECTIVE: The aim of this study was to investigate whether olfactory dysfunction was further aggravated as the result of neurologic involvement. METHODS: Sixteen patients diagnosed with NBD and 16 healthy control patients with similar demographic characteristics were recruited as the healthy control group...
August 31, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28862099/association-of-killer-cell-immunoglobulin-like-receptor-kir-genes-and-their-hla-ligands-with-susceptibility-to-beh%C3%A3-et-s%C3%A2-disease
#14
H Mohammad-Ebrahim, E Kamali-Sarvestani, M Mahmoudi, M Beigy, J Karami, N Ahmadzadeh, F Shahram
OBJECTIVES: Behçet's disease (BD) is a systemic inflammatory disorder with remissions and exacerbations. It is thought that defects in the natural killer (NK) cell repertoire may be involved in BD through killer cell immunoglobulin-like receptors (KIRs). This study aimed to evaluate KIR and HLA genes, their interactions in BD patients, and their associations with clinical manifestations. METHOD: The presence or absence of KIR and HLA alleles and genotypes was analysed by polymerase chain reaction sequence-specific primer on genomic DNA of 397 BD patients and 300 healthy controls...
September 1, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28860798/beh%C3%A3-et-s-syndrome-providing-integrated-care
#15
REVIEW
Sinem Nihal Esatoglu, Zekayi Kutlubay, Didar Ucar, Ibrahim Hatemi, Ugur Uygunoglu, Aksel Siva, Gulen Hatemi
Behçet's syndrome (BS) is a multisystem vasculitis that presents with a variety of mucocutaneous manifestations such as oral and genital ulcers, papulopustular lesions and erythema nodosum as well as ocular, vascular, gastrointestinal and nervous system involvement. Although it occurs worldwide, it is especially prevalent in the Far East and around the Mediterranean Sea. Male gender and younger age at disease onset are associated with a more severe disease course. The management of BS depends on the severity of symptoms...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/28860590/distinct-clinical-features-between-acute-and-chronic-progressive-parenchymal-neuro-beh%C3%A3-et-disease-meta-analysis
#16
Mizuho Ishido, Nobuyuki Horita, Masaki Takeuchi, Etsuko Shibuya, Takahiro Yamane, Tatsukata Kawagoe, Takehito Ishido, Kaoru Minegishi, Ryusuke Yoshimi, Yohei Kirino, Shunsei Hirohata, Yoshiaki Ishigatsubo, Mitsuhiro Takeno, Takeshi Kaneko, Nobuhisa Mizuki
Neuro-Behçet's disease (NBD) is subcategorized into parenchymal-NBD (P-NBD) and non-parenchymal-NBD types. Recently, P-NBD has been further subdivided into acute P-NBD (A-P-NBD) and chronic progressive P-NBD (CP-P-NBD). Although an increasing number of studies have reported the various clinical features of A-P-NBD and CP-P-NBD over the last two decades, there was a considerable inconsistency. Two investigators systematically searched four electrical databases to detect studies that provided sufficient data to assess the specific characteristics of A-P-NBD and CP-P-NBD...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28853535/intravitreal-dexamethasone-implant-as-an-adjunct-weapon-for-severe-and-refractory-uveitis-in-beh%C3%A3-et-s-disease
#17
Claudia Fabiani, Giacomo Emmi, Giuseppe Lopalco, Lorenzo Vannozzi, Daniela Bacherini, Silvana Guerriero, Rossella Franceschini, Bruno Frediani, Florenzo Iannone, Gian Marco Tosi, Donato Rigante, Luca Cantarini
BACKGROUND: The evidence on the use of dexamethasone implants in the treatment of Behçet's disease (BD)-related uveitis is limited to a few cases. OBJECTIVES: To evaluate the efficacy of dexamethasone implants on ocular functional, morphological, and clinical parameters in BD patients with severe refractory uveitis. METHODS: Five eyes from five BD patients were enrolled. A single intravitreal dexamethasone injection was applied to each eye...
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28844827/beh%C3%A3-et-disease-serum-is-immunoreactive-to-neurofilament-medium-which-share-common-epitopes-to-bacterial-hsp-65-a-putative-trigger
#18
S Lule, A I Colpak, B Balci-Peynircioglu, Y Gursoy-Ozdemir, S Peker, U Kalyoncu, A Can, N Tekin, D Demiralp, T Dalkara
Autoimmune and dysimmune inflammatory mechanisms on a genetically susceptible background are implicated in the etiology of Behçet's Disease (BD). Heat-shock protein-65 (HSP-65) derived from Streptococcus sanguinis was proposed as a triggering factor based on its homology with human HSP-60. However, none of the autoantigens identified so far in sera from BD share common epitopes with bacterial HSP-65 or has a high prevalence. Here, we report that sera from BD patients are immunoreactive against filamentous neuronal processes in the mouse brain, retina and scrotal skin in great majority of patients...
August 24, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28844047/cumulative-retention-rate-of-adalimumab-in-patients-with-beh%C3%A3-et-s-disease-related-uveitis-a-four-year-follow-up-study
#19
Claudia Fabiani, Jurgen Sota, Antonio Vitale, Donato Rigante, Giacomo Emmi, Lorenzo Vannozzi, Daniela Bacherini, Giuseppe Lopalco, Silvana Guerriero, Stefano Gentileschi, Marco Capozzoli, Rossella Franceschini, Bruno Frediani, Mauro Galeazzi, Florenzo Iannone, Gian Marco Tosi, Luca Cantarini
BACKGROUND/AIMS: Adalimumab (ADA) has been shown to be an effective treatment for Behçet's disease (BD)-related uveitis. We aimed at evaluating the cumulative retention rate of ADA during a 48-month follow-up period in patients with BD-related uveitis, the impact of a concomitant use of disease modifying anti-rheumatic drugs (DMARDs) on ADA retention rate, and differences according to the various lines of biologic therapy (ie, first- vs second-line or more). Predictive factors of response to ADA were also investigated...
August 26, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28843707/cerebral-pseudo-tumoral-neuro-behcet-histological-demonstration-of-an-inflammatory-and-vascular-disease
#20
Fleur Cohen-Aubart, Dimitri Psimaras, Damien Galanaud, Franck Bielle, Valérie Touitou, Julien Haroche, Zahir Amoura
No abstract text is available yet for this article.
August 12, 2017: Clinical Neurology and Neurosurgery
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