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https://www.readbyqxmd.com/read/28221758/synthesis-and-fabrication-of-collagen-coated-ostholamide-electrospun-nanofiber-scaffold-for-wound-healing
#1
Subramani Kandhasamy, Sathiamurthi Perumal, Balaraman Madhan, Narayanan Umamaheswari, Javaid Ahmad Banday, Paramasivan Thirumalai Perumal, Vichangal Pridiuldi Santhanakrishnan
A novel scaffold for effective wound healing treatment was developed utilizing natural product bearing collagen based biocompatible electro-spun nanofibres. Initially, ostholamide (OSA) was synthesized from osthole (a natural coumarin), characterized by 1H, 13C, DEPT-135 NMR, ESI-MS and FT-IR spectroscopy analysis. OSA was incorporated into Polyhydroxybutyrate (PHB) and Gelatin (GEL), which serve as templates for electro-spun nanofibers. The coating of OSA-PHB-GEL nanofibers with collagen resulted in PHB-GEL-OSA-COL nanofibrous scaffold which mimics extra cellular matrix and serves as an effective biomaterial for tissue engineering applications, especially for wound healing...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28220178/a-photo-degradable-supramolecular-hydrogel-for-selective-delivery-of-microrna-into-3d-cultured-cells
#2
Zhengquan Zhou, Qikun Yi, Tingting Xia, Wencui Yin, Adnan A Kadi, Jinbo Li, Yan Zhang
Multi-functional supramolecular hydrogels have emerged as smart biomaterials for diverse biomedical applications. Here we report a multi-functional supramolecular hydrogel formed by the conjugate of the bioactive GRGDS peptide with biaryltetrazole that is the substrate of photo-click reaction. The hydrogel was used as a biocompatible matrix to encapsulate live cells for 3D culture. The presence of the RGD epitope in the hydrogelator enhanced the interaction of the nanofiber with integrin over-expressing cells, which resulted in the selective enhancement in the miRNA delivery into the encapsulated U87 cells...
February 21, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28216796/design-and-synthesis-of-nanofibers-of-self-assembled-de-novo-glycoconjugates-towards-mucosal-lining-restoration-and-anti-inflammatory-drug-delivery
#3
Jie Zhou, Michael O'Keeffe, Gongxian Liao, Fan Zhao, Cox Terhorst, Bing Xu
The medical practice for IBD is solely based on anti-inflammatory drugs, but the outcome is far from ideal. Our long-term research goal is to seek a better clinical outcome by combining the anti-inflammatory therapy with physical mucus layer restoration. As the first step towards that objective, we choose to develop self-assembled hydrogels of de novo glycoconjugates that consist of anti-inflammatory drugs and glycopeptides. By covalently linking peptides (e.g., nap-phe-phe-lys), saccharides (e.g., glucosamine), and an anti-inflammatory drug (i...
October 6, 2016: Tetrahedron
https://www.readbyqxmd.com/read/28216559/aloe-vera-for-tissue-engineering-applications
#4
REVIEW
Shekh Rahman, Princeton Carter, Narayan Bhattarai
Aloe vera, also referred as Aloe barbadensis Miller, is a succulent plant widely used for biomedical, pharmaceutical and cosmetic applications. Aloe vera has been used for thousands of years. However, recent significant advances have been made in the development of aloe vera for tissue engineering applications. Aloe vera has received considerable attention in tissue engineering due to its biodegradability, biocompatibility, and low toxicity properties. Aloe vera has been reported to have many biologically active components...
February 14, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28216468/enhanced-ocular-efficacy-of-topically-delivered-dorzolamide-with-nanostructured-mucoadhesive-microparticles
#5
Chun Gwon Park, Young Kook Kim, Se-Na Kim, Seung Ho Lee, Beom Kang Huh, Min-A Park, Hyein Won, Ki Ho Park, Young Bin Choy
Dorzolamide eye drops are widely prescribed to reduce intraocular pressure (IOP) in the treatment of ocular hypertension and glaucoma. However, in an eye drop formulation, dorzolamide is rapidly cleared from the preocular space, hence requiring multiple daily administrations. Here, we sought to increase the preocular retention of dorzolamide using nanostructured, mucoadhesive microparticles (MUCO_NM) as carriers for topical delivery to the eye. MUCO_NM were prepared by freeze-milling dorzolamide-loaded, electrospun nanofibers composed of poly(lactic-co-glycolic acid) and polyethylene glycol...
February 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28216302/long-term-antimicrobial-effect-of-nisin-released-from-electrospun-triaxial-fiber-membranes
#6
Daewoo Han, Shalli Sherman, Shaun Filocamo, Andrew J Steckl
: Electrospun membranes encapsulating nisin in the core of multi-layer coaxial fibers, with a hydrophobic PCL intermediate layer and a hygroscopic cellulose acetate sheath, have been demonstrated to provide long-term antimicrobial activity combined with a hygroscopic outer layer. Antimicrobial performance has been evaluated using modified versions of the antimicrobial textile test AATCC 100 and AATCC 147 against Staphylococcus aureus. The AATCC 147 tests indicate that antimicrobial activity persists up to 7 days...
February 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28214585/preparation-and-biocompatibility-of-a-chitin-nanofiber-gelatin-composite-film
#7
Yoko Ogawa, Kazuo Azuma, Hironori Izawa, Minoru Morimoto, Kosuke Ochi, Tomohiro Osaki, Norihiko Ito, Yoshiharu Okamoto, Hiroyuki Saimoto, Shinsuke Ifuku
The development of chitin-based materials with favorable mechanical properties and biocompatibility is an important research goal owing to the wide-ranging practical applications. In this study, a composite film was prepared using chitin nanofibers and gelatin. The CNF/gelatin composite film was highly viscous and had a fine nanofiber structure. The transmittances indicated high transparency, regardless of nanofiber content. The water content of the CNF/gelatin composite film increased linearly as the gelatin content increased...
February 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28211362/marrow-isolated-adult-multilineage-inducible-cells-embedded-within-a-biologically-inspired-construct-promote-recovery-in-a-mouse-model-of-peripheral-vascular-disease
#8
Cristina Grau-Monge, Gaëtan J-R Delcroix, Andrea Bonnin-Marquez, Mike Valdes, Ead Lewis Mazen Awadallah, Daniel F Quevedo, Maxime R Armour, Ramon B Montero, Paul C Schiller, Fotios M Andreopoulos, Gianluca D'Ippolito
Peripheral vascular disease is one of the major vascular complications in individuals suffering from diabetes and in the elderly that is associated with significant burden in terms of morbidity and mortality. Stem cell therapy is being tested as an attractive alternative to traditional surgery to prevent and treat this disorder. The goal of this study was to enhance the protective and reparative potential of marrow-isolated adult multilineage inducible (MIAMI) cells by incorporating them within a bio-inspired construct (BIC) made of two layers of gelatin B electrospun nanofibers...
February 17, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28211116/ac-dielectrophoretic-manipulation-and-electroporation-of-vaccinia-virus-using-carbon-nanoelectrode-arrays
#9
Foram Ranjeet Madiyar, Sherry Basset, Omer Farooq, Stefan Rothenburg, Christopher Culbertson, Jun Li
This paper reports the capture and detection of vaccinia virus particles based on AC dielectrophoresis (DEP) and electrochemical impedance measurements employing an embedded vertically aligned carbon nanofiber (VACNF) nanoelectrode array (NEA) versus a macroscopic indium-tin-oxide (ITO) transparent electrode in a "points-and-lid" configuration. The nano-DEP device was fabricated by bonding two SU-8 covered electrodes patterned using photolithography. The bottom electrode contains a 200 × 200 μm(2) active region on a randomly distributed NEA and the top electrode contains a microfluidic channel in SU-8 spin-coated on ITO to guide the flow of the virus solution...
February 17, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28209035/electrospun-perovskite-nanofibers
#10
Dongsheng Chen, Yanyan Zhu
CH3NH3PbI3 perovskite nanofibers were synthesized by versatile electrospinning techniques. The synthetic CH3NH3PbI3 nanofibers were characterized by X-ray diffraction, scanning electron microscopy, thermogravimetric analysis, and photoluminescence. As counter electrodes, the synthesized nanofibers increased the performance of the dye-sensitized solar cells from 1.58 to 2.09%. This improvement was attributed to the enhanced smoothness and efficiency of the electron transport path. Thus, CH3NH3PbI3 perovskites nanofibers are potential alternative to platinum counter electrodes in dye-sensitized solar cells...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28209034/production-of-conductive-pedot-coated-pva-go-composite-nanofibers
#11
Nur Afifah Zubair, Norizah Abdul Rahman, Hong Ngee Lim, Yusran Sulaiman
Electrically conductive nanofiber is well known as an excellent nanostructured material for its outstanding performances. In this work, poly(3,4-ethylenedioxythiophene) (PEDOT)-coated polyvinyl alcohol-graphene oxide (PVA-GO)-conducting nanofibers were fabricated via a combined method using electrospinning and electropolymerization techniques. During electrospinning, the concentration of PVA-GO solution and the applied voltage were deliberately altered in order to determine the optimized electrospinning conditions...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28209029/synthesis-and-electrochemical-property-of-limn2o4-porous-hollow-nanofiber-as-cathode-for-lithium-ion-batteries
#12
Lianfeng Duan, Xueyu Zhang, Kaiqiang Yue, Yue Wu, Jian Zhuang, Wei Lü
The LiMn2O4 hollow nanofibers with a porous structure have been synthesized by modified electrospinning techniques and subsequent thermal treatment. The precursors were electrospun directly onto the fluorine-doped tin oxide (FTO) glass. The heating rate and FTO as substrate play key roles on preparing porous hollow nanofiber. As cathode materials for lithium-ion batteries (LIBs), LiMn2O4 hollow nanofibers showed the high specific capacity of 125.9 mAh/g at 0.1 C and a stable cycling performance, 105.2 mAh/g after 400 cycles...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28206692/patchy-nanofibers-from-the-thin-film-self-assembly-of-a-conjugated-diblock-copolymer
#13
Emily L Kynaston, Yuan Fang, Joseph G Manion, Nimrat K Obhi, Jane Y Howe, Dmitrii F Perepichka, Dwight S Seferos
An unexpected morphology comprising patchy nanofibers can be accessed from the self-assembly of an all-conjugated, polyselenophene-block-polythiophene copolymer. This morphology consists of very small (<10 nm), polythiophene- and polyselenophene-rich domains and is unprecedented for both conjugated polymers and diblock copolymers in general. We propose that the patchy morphology occurs from the enhanced miscibility of the blocks arising from the longer alkyl chains in comparison to similar block copolymers with shorter alkyl chains, which fully phase separate, as well as the difference in rigidity between the polythiophene and polyselenophene blocks...
February 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28198633/tuning-the-hydration-and-lubrication-of-the-embedded-load-bearing-hydrogel-fibers
#14
Ran Zhang, Yange Feng, Shuanhong Ma, Meirong Cai, Jun Yang, Bo Yu, Feng Zhou
One of the most prominent properties of hydrogels is their excellent hydro-lubrication that derives from the strong hydration of the gel network. However, excessive hydration makes hydrogels very poor mechanical property, which limits the practical applications. Here, the novel composite surface of hydrogel nanofibers embedded in anodic aluminum oxide (AAO) substrate was prepared and exhibited both excellent lubrication and high load bearing capacity. Through the copolymerization of acrylic acid (AA) and 3-Sulfopropyl methacrylate potassium salt (SPMA), gel network swelled sufficiently in aqueous solution and caused high osmotic pressure repulsion to bear heavy load, and hence performed excellent aqueous lubrication (µ~0...
February 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28198135/hierarchically-ordered-polymer-nanofiber-shish-kebabs-as-a-bone-scaffold-material
#15
Xi Chen, Sarah E Gleeson, Tony Yu, Nasreen Khan, Robert W Yucha, Michele Marcolongo, Christopher Y Li
The ideal bone scaffold harnesses the body's ability to regenerate bone in critical size defects. A potential strategy to design the ideal bone scaffold is to mimic the natural structure of bone at the molecular level. The orientation and spatial distribution of nanocrystals in the organic matrix are two important and distinctive structural characteristics associated with natural bone. There has yet to be a synthetic system or scaffold that is able to control both the spatial distribution and orientation of the HAP crystalline structure...
February 15, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28197024/nanotechnology-in-urology
#16
REVIEW
Sudhindra Jayasimha
INTRODUCTION: Nanotechnology has revolutionized our approach to medical diagnostics as well as therapeutics and has spanned an entirely new branch of research. This review addresses the potential applications of Nanotechnology in Urology. This article is based on the Dr. Sitharaman Best Essay award of the Urological Society of India for 2016. METHODS: A PubMed search was performed for all relevant articles using the terms, "nanotechnology, nanoparticles, nanoshells, nanoscaffolds, and nanofibers...
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28196320/flexible-and-highly-biocompatible-nanofiber-based-electrodes-for-neural-surface-interfacing
#17
Dong Nyoung Heo, Han-Jun Kim, Yijae Lee, Min Heo, Sang Jin Lee, Donghyun Lee, Sun Hee Do, Soo Hyun Lee, Il Keun Kwon
Polyimide (PI)-based electrodes have been widely used as flexible biosensors in implantable device applications for recording biological signals. However, the long-term quality of neural signals obtained from PI-based nerve electrodes tends to decrease due to nerve damage by neural tissue compression, mechanical mismatch and insufficient fluid exchange between the neural tissue and electrodes. Here, we resolve these problems with a developed PI nanofiber (NF)-based nerve electrode for stable neural signal recording, which can be fabricated via electrospinning and inkjet printing...
February 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/28195446/host-materials-transformable-in-tumor-microenvironment-for-homing-theranostics
#18
Pei-Pei Yang, Qiang Luo, Guo-Bin Qi, Yu-Juan Gao, Bing-Nan Li, Jing-Ping Zhang, Lei Wang, Hao Wang
A pathology-adaptive nanosystem, in which nest-like hosts are built based on nanofibers that are transformed from i.v. injected nanoparticles under acidic tumor microenvironment. The solid tumor is artificially modified by nest-like hosts readily and firmly, resulting in highly efficient accumulation and stabilization of guest theranostics. This strategy shows great potential for the theranostics delivery to tumors.
February 13, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28192154/electrospun-polyurethane-nanofiber-scaffolds-with-ciprofloxacin-oligomer-effect-on-drug-release-and-cell-attachment-versus-free-drug
#19
Meghan Ee Wright, Ian C Parrag, Meilin Yang, J Paul Santerre
An electrospun degradable polycarbonate urethane (PCNU) nanofiber scaffold loaded with antibiotic was investigated in terms of antibacterial efficacy and cell compatibility for potential use in gingival tissue engineering. Antimicrobial oligomer (AO), a compound which consists of two molecules of ciprofloxacin (CF) covalently bound via hydrolysable linkages to triethylene glycol (TEG), was incorporated via a one-step blend electrospinning process using a single solvent system at 7 and 15% w/w equivalent CF with respect to the PCNU...
February 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28191928/self-assembling-multidomain-peptide-nanofibers-for-delivery-of-bioactive-molecules-and-tissue-regeneration
#20
Amanda N Moore, Jeffrey D Hartgerink
Multidomain peptides (MDPs) are a class of self-assembling peptides that are organized in a β-sheet motif, resulting in a nanofibrous architecture. This structure is stabilized by hydrophobic packing in the fiber core and a hydrogen-bonding network down the fiber long axis. Under easily controllable conditions, regulated by electrostatic interactions between the peptides and the pH and salt composition of the solvent, the nanofiber length can be dramatically extended, resulting in fiber entanglement and hydrogel formation...
February 13, 2017: Accounts of Chemical Research
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