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exposed fractures

Kerrin C DePeter, Stephen M Blumberg, Sarah Dienstag Becker, James A Meltzer
BACKGROUND: Despite being an effective analgesic for children with fractures, some clinicians may avoid prescribing ibuprofen due to its potentially harmful effect on bone healing. OBJECTIVE: To determine if exposure to ibuprofen is associated with an increased risk of bone healing complications in children with fractures. METHODS: We performed a retrospective study of children aged 6 months to 17 years who presented to the pediatric emergency department (PED) with a fracture of the tibia, femur, humerus, scaphoid, or fifth metatarsus and who followed up with the orthopedic service...
October 14, 2016: Journal of Emergency Medicine
Wenhao Song, Dongsheng Zhou, Yu He
BACKGROUND: The aim of this study was to compare the biomechanical characteristics between bilateral and unilateral lumbo-iliac fixation in unilateral comminuted sacral fractures (USF) by finite element analysis. METHODS: A 3-dimensional finite element model of unilateral sacral fractures was simulated. Three kinds of implants were instrumented into the model, including the unilateral lumbopelvic fixation (ULF), bilateral lumbopelvic fixation (BLF), and unilateral iliac fixation with bilateral lumbar pedicle screws (UBF)...
October 2016: Medicine (Baltimore)
Tove Bokrantz, Charlotta Ljungman, Thomas Kahan, Kristina B Boström, Jan Hasselström, Per Hjerpe, Dan Mellström, Linus Schiöler, Karin Manhem
OBJECTIVE: The objective is to investigate if treatment with thiazides reduces the risk of osteoporotic fractures in hypertensive patients in primary healthcare. Further we aimed to examine the impact of duration of thiazide use, the consequences of discontinuation of treatment, and the possible difference in effect between men and women. METHOD: This retrospective cohort study includes 57 822 individuals, 45 years and older, diagnosed with hypertension during 2001-2008 in the Swedish Primary Care Cardiovascular Database...
October 5, 2016: Journal of Hypertension
Antonius Ljj Bronckers, Donacian M Lyaruu
Supraoptimal intake of fluoride (F) induces structural defects in forming enamel, dentin and bone and increases the risk of bone fractures. Enamel formation is most sensitive to low levels of F and the degree of enamel fluorosis depends on the mouse strain. What molecular mechanism is responsible for these differences in sensitivity is unclear. Maturation ameloblasts transport bicarbonates into enamel in exchange for Cl- to buffer protons released by forming apatites. We proposed that F-enhanced mineral deposition releases excess of protons that will affect mineralization in forming enamel...
October 12, 2016: Bone
Thomas Mücke, Christian R Krestan, David A Mitchell, Jan S Kirschke, Arno Wutzl
For patients with malignant disease taking bisphosphonates and denosumab, the incidence of medication-related osteonecrosis of the jaw (MRONJ) is up to 15% in contrast to 0.01% in patients with osteoporosis. Clinical presentation of MRONJ extends from asymptomatic exposure of bone in 94% of patients to severe cases of mandibular fractures in a minority of 4.5%. The strongest risk factors for MRONJ are invasive dental procedures and dental infections. Advances in imaging provide more preoperation information compared with panoramic radiograph...
July 2016: Seminars in Musculoskeletal Radiology
Fabiano Luiz Heggendorn, Gabriela Cristina de Carvalho Silva, Elisama Azevedo Cardoso, Helena Carla Castro, Lúcio Souza Gonçalves, Eliane Pedra Dias, Viviane de Oliveira Freitas Lione, Márcia Teresa Soares Lutterbach
This study assessed the cell viability of the inoculation vehicle of BACCOR (a combination of sulfate-reducing bacteria plus a culture media for bacteria), a biopharmaceutical product under development for dental use as aid in fractured endodontic file removal from the root canal. Different culture media for bacteria were evaluated: modified Postgate E (MCP-E mod), Modified Postgate E without Agar-agar (MCP-E w/Ag), Postgate C with Agar-agar (MCP-C Ag) and Postgate C without Agar-agar (MCP-C w/Ag). Cytotoxicity was quantified by the MTT test, exposing L929 and Vero cell lines to the vehicles over 24 h...
2016: Dental Materials Journal
Charlotte Beaudart, Eugène McCloskey, Olivier Bruyère, Matteo Cesari, Yves Rolland, René Rizzoli, Islène Araujo de Carvalho, Jotheeswaran Amuthavalli Thiyagarajan, Ivan Bautmans, Marie-Claude Bertière, Maria Luisa Brandi, Nasser M Al-Daghri, Nansa Burlet, Etienne Cavalier, Francesca Cerreta, Antonio Cherubini, Roger Fielding, Evelien Gielen, Francesco Landi, Jean Petermans, Jean-Yves Reginster, Marjolein Visser, John Kanis, Cyrus Cooper
BACKGROUND: Sarcopenia is increasingly recognized as a correlate of ageing and is associated with increased likelihood of adverse outcomes including falls, fractures, frailty and mortality. Several tools have been recommended to assess muscle mass, muscle strength and physical performance in clinical trials. Whilst these tools have proven to be accurate and reliable in investigational settings, many are not easily applied to daily practice. METHODS: This paper is based on literature reviews performed by members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) working group on frailty and sarcopenia...
October 5, 2016: BMC Geriatrics
Fei Deng, Shuling Wang, Hua Xin
Roots of Allium cepa were exposed to six CuO NPs suspensions (0, 5, 10, 20, 40, 80 mg L(-1)) in this study. Results revealed that with the increase of CuO NPs concentration, the Cu content in roots increased significantly. Compared to control, onion roots treated with CuO NPs (except 5 mg L(-1) suspension) grew slowly after 24 h. The surface of the root cap and meristematic zone were obviously damaged. The apical meristem of roots treated by 10 mg L(-1) and above concentrations stopped division. The nucleus of meristematic cells deformed, and nucleoli number increased...
October 4, 2016: Bulletin of Environmental Contamination and Toxicology
Leonie Jacobs, Evelyne Delezie, Luc Duchateau, Klara Goethals, Frank A M Tuyttens
Before broilers are slaughtered, several parties are involved in catching, loading, transportation and lairage. During these pre-slaughter activities, broilers are exposed to a variety of stressors. A detailed understanding of how broiler welfare is impaired during each stage could help the responsible parties to make targeted improvements. The aim of this study was to identify welfare problems occurring during the consecutive stages of commercial broiler transportation and to identify risk factors associated with the identified welfare problems...
October 4, 2016: Poultry Science
Yanping Cheng, Pawel Gasior, Masahiko Shibuya, Kamal Ramzipoor, Chang Lee, Edward A Estrada, Daniell Dokko, Jenn C McGregor, Gerard B Conditt, Greg L Kaluza, Juan F Granada
BACKGROUND: Clinically available bioresorbable scaffolds (BRS) rely on polymer crystallinity to achieve mechanical strength resulting in limited overexpansion capabilities and structural integrity when exposed to high-loading conditions. We aimed to evaluate the biomechanical behavior and vascular healing profile of a novel, sirolimus-eluting, high-molecular-weight, amorphous poly-l-lactic acid-based BRS (Amaranth BRS). METHODS AND RESULTS: In vitro biomechanical testing was performed under static and cyclic conditions...
October 2016: Circulation. Cardiovascular Interventions
Liang Chen, Barry D Hammond, Gary Alex, Byoung In Suh
STATEMENT OF PROBLEM: Intraoral repair of porcelain or other silica-based ceramics typically requires the use of silane in the repair protocol. Some porcelain intraoral repairs also involve bonding to exposed or involved tooth tissues including dentin. A study is needed to evaluate whether the cross-contamination of dentin with silane affects bond strength to this tissue. PURPOSE: The purpose of this in vitro study was to investigate the effect of silane cross-contamination on dentin bond strength...
September 28, 2016: Journal of Prosthetic Dentistry
V F Wandscher, C D Bergoli, I F Limberger, T P Cenci, P Baldissara, L F Valandro
OBJECTIVE: This article aims to present a fractographic analysis of an anterior tooth restored with a glass fiber post with parallel fiber arrangement, taking into account force vectors, finite element analysis, and scanning electron microscopy (SEM). METHODS: A patient presented at the Faculty of Dentistry (Federal University of Santa Maria, Brazil) with an endodontically treated tooth (ETT), a lateral incisor that had a restorable fracture. The treatment was performed, and the fractured piece was analyzed using stereomicroscopy, SEM, and finite element analysis...
September 2016: Operative Dentistry
Andreas Fuchs, Stefan Hartmann, Karen Ernestus, Grit Mutzbauer, Christian Linz, Roman C Brands, Alexander C Kübler, Urs D A Müller-Richter
BACKGROUND: Mandibular pseudocarcinomatous hyperplasia is a rare and generally benign pathology. We report on one of these rare cases. CASE PRESENTATION: The case history of a 73-year-old white man stated that he had a carcinoma of the oropharynx, which was primarily treated with radiotherapy and chemotherapy 4 years prior. As a result of radiotherapy he developed an osteoradionecrosis of his mandible and a consecutive pathological fracture of his left mandibular angle...
September 29, 2016: Journal of Medical Case Reports
Dalia Somjen, Zachary T Sharfman, Sara Katzburg, Orli Sharon, Eran Maman, Moshe Salai, Naftali Stern, Oleg Dolkart
BACKGROUND: Anticoagulant therapy is a mainstay of treatment subsequent to major orthopedic surgeries. Evidence linking anticoagulant therapy, osteoporosis, and delayed fracture healing is not conclusive. We have previously reported that rivaroxaban significantly inhibited cell growth and energy metabolism in a human osteoblastic cell line. This study analyzed the response of primary female osteoblast cells to rivaroxaban in combination with various bone-modulating hormones. METHODS: Bone samples were taken from both premenopausal (pre-Ob) and postmenopausal (post-Ob) women...
August 11, 2016: Connective Tissue Research
N A Johnson, C Uzoigwe, M Venkatesan, V Burgula, A Kulkarni, J N Davison, R U Ashford
INTRODUCTION Intramedullary nailing is a common treatment for proximal femoral fractures. Fracture of the nail is a rare but devastating complication that exposes often frail patients to complex revision surgery. We investigated which risk factors predict nail failure. METHODS We reviewed all cases of nail breakage seen over a 10-year period in a single busy trauma unit; 22 nail fractures were seen in 19 patients. Comparison was made with a group of 209 consecutive patients who underwent intramedullary fixation of a proximal femur fracture with no nail breakage over a 2-year period...
September 23, 2016: Annals of the Royal College of Surgeons of England
Kyungjin Kim, Hao Luo, Ankit K Singh, Ting Zhu, Samuel Graham, Olivier N Pierron
A singular critical onset strain value has been used to characterize the strain limits of barrier films used in flexible electronics. However, such metrics do not account for time-dependent or environmentally assisted cracking, which can be critical in determining the overall reliability of these thin-film coatings. In this work, the time-dependent channel crack growth behavior of silicon nitride barrier films on poly(ethylene terephthalate) (PET) substrates is investigated in dry and humid environments by tensile tests with in situ optical microscopy and numerical models...
October 3, 2016: ACS Applied Materials & Interfaces
Manju Raj Kumari, Manjunath Mysore Krishnaswamy
INTRODUCTION: Success of any endodontic treatment depends on strict adherence to 'endodontic triad'. Preparation of root canal system is recognized as being one of the most important stages in root canal treatment. At times, we inevitably end up damaging root dentin which becomes a Gateway for infections like perforation, zipping, dentinal cracks and minute intricate fractures or even vertical root fractures, thereby resulting in failure of treatment. Several factors may be responsible for the formation of dentinal cracks like high concentration of sodium hypochlorite, compaction methods and various canal shaping methods...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
X Wu, D Wei, B Sun, X N Wu
UNLABELLED: Non-adherence to bisphosphonates exposes the elderly female osteoporosis patients to an increased risk of fracture. This was one of the first studies to explore the relationship between medication adherence and self-perception of aging. Feelings of lacking control and expectations for negative events, beliefs of illness's chronic duration nature, and its linkage with aging were associated with of poor medication adherence. INTRODUCTION: To examine the relationship between medication adherence to bisphosphonates and self-perception of aging in elderly female patients with osteoporosis...
October 2016: Osteoporosis International
Genevieve A Kahrilas, Jens Blotevogel, Edward R Corrin, Thomas Borch
Hydraulic fracturing fluid (HFF) additives are used to enhance oil and gas extraction from unconventional shale formations. Several kilometers downhole, these organic chemicals are exposed to temperatures up to 200 °C, pressures above 10 MPa, high salinities, and a pH range from 5-8. Despite this, very little is known about the fate of HFF additives under these extreme conditions. Here, stainless steel reactors are used to simulate the downhole chemistry of the commonly used HFF biocide glutaraldehyde (GA)...
October 18, 2016: Environmental Science & Technology
A Bhattacharyya, S Kumar
Deformity of wrist is very common after mal union of extra articular fractures over distal end of Radius. It causes limitation of movements too in different directions with or without pain. Deformity may be treated by different types of corrective osteotomy. We treated cases of this type of malunion with Fernandez osteotomy. This study is to observe the amount of correction and recovery of functional status in patients with malunited distal radius fractures treated with Fernandez osteotomy. This is a prospective study...
July 2016: Mymensingh Medical Journal: MMJ
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