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https://www.readbyqxmd.com/read/29155486/toxic-stress-and-child-refugees
#1
John S Murray
The purpose of this article was to describe the phenomenon of toxic stress and its impact on the physical and mental health of child refugees. Almost two decades ago, researchers found that recurring adverse childhood events (ACEs; e.g., physical, psychological, and sexual abuse, neglect, and household dysfunction such as substance abuse, mental illness, and criminal behavior) were associated with a significant increase in serious illnesses during adulthood. Illnesses include heart, lung, and liver disease, cancer, and bone fractures...
November 20, 2017: Journal for Specialists in Pediatric Nursing: JSPN
https://www.readbyqxmd.com/read/29154300/fracture-generation-in-human-vertebrae-under-compression-loading-the-influence-of-pedicle-preservation-and-bone-mineral-density-on-in-vitro-fracture-behavior
#2
Michael Kraxenberger, Christian Schröder, Tobias Geith, Andreas Büttner, Christoph von SchulzePeelengahr, Christof Birkenmaier, Peter Muller, Volkmar Jansson, Bernd Wegener
BACKGROUND: Fractured vertebral bodies are a common and wide spread health issue. OBJECTIVE: The purpose of this study was to develop a standardized method to experimentally generate compression fractures in vertebral bodies. The influence of the pedicles has been investigated with regards to the fracture behavior. The correlation between bone mineral density (BMD), the cause of fractures and the fracture behavior was investigated. METHODS: Twenty-one fresh frozen human lumbar spines were examined for bone mineral density (BMD) by means of quantitative computed tomography (qCT)...
November 10, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29134408/glucosamine-reduces-the-inhibition-of-proteoglycan-metabolism-caused-by-local-anaesthetic-solution-in-human-articular-cartilage-an-in-vitro-study
#3
Abhinav Gulihar, Shalin Shaunak, Pinelopi Linardatou Novak, Parthiban Vinayakam, Baljinder Dhinsa, Grahame Taylor
BACKGROUND: We assessed whether local anaesthetics caused inhibition of proteoglycan metabolism in human articular cartilage and whether the addition of Glucosamine sulphate could prevent or allow recovery from this adverse effect on articular cartilage metabolism. METHODS: Cartilage explants obtained from 13 femoral heads from fracture neck of femur patients (average age 80 years, 10 female) were exposed to either 1% Lidocaine, 2% Lidocaine, 0.25% Bupivacaine, 0...
November 13, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29125848/early-decreased-tlr2-expression-on-monocytes-is-associated-with-their-reduced-phagocytic-activity-and-impaired-maturation-in-a-porcine-polytrauma-model
#4
Lukas Schimunek, Rafael Serve, Michel P J Teuben, Philipp Störmann, Birgit Auner, Mathias Woschek, Roman Pfeifer, Klemens Horst, Tim-P Simon, Miriam Kalbitz, Ramona Sturm, Hans-C Pape, Frank Hildebrand, Ingo Marzi, Borna Relja
In their post-traumatic course, trauma patients suffering from multiple injuries have a high risk for immune dysregulation, which may contribute to post-injury complications and late mortality. Monocytes as specific effector cells of the innate immunity play a crucial role in inflammation. Using their Pattern Recognition Receptors (PRRs), notably Toll-Like Receptors (TLR), the monocytes recognize pathogens and/or pathogen-associated molecular patterns (PAMPs) and organize their clearance. TLR2 is the major receptor for particles of gram-positive bacteria, and initiates their phagocytosis...
2017: PloS One
https://www.readbyqxmd.com/read/29115655/delayed-bipedicled-flap-an-alternative-and-new-method-for-reconstruction-of-distal-leg-defect-after-gunshot-trauma-a-case-report-and-review-of-the-literature
#5
Ali Rıza Yıldırım, Murat İğde, Mehmet Onur Öztürk, Hasan Murat Ergani, Ramazan Erkin Ünlü
Shotgun injury is a trauma that leads to soft tissue defects, in which important structures such as the tendon and bone are exposed with fractures in the distal lower extremity. Because this region has insufficient soft tissue support, local flap options are highly limited. Although the most suitable options are free or perforator flaps for contemporarily reconstructing that region; owing to such highenergy traumas, the available local flaps are becoming more suitable. Besides having various advantages, bipedicled flaps are commonly used for reconstructing small- and medium-sized lower extremity defects...
November 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29097751/microfluidic-preparation-of-anchored-cell-membrane-sheets-for-in-vitro-analyses-and-manipulation-of-the-cytoplasmic-face
#6
Shin Izuta, Satoshi Yamaguchi, Ryuji Misawa, Shinya Yamahira, Modong Tan, Masahiro Kawahara, Tomoko Suzuki, Tomoko Takagi, Kae Sato, Motonao Nakamura, Teruyuki Nagamune, Akimitsu Okamoto
Molecular networks on the cytoplasmic faces of cellular plasma membranes are critical research topics in biological sciences and medicinal chemistry. However, the selective permeability of the cell membrane restricts the researchers from accessing to the intact intracellular factors on the membrane from the outside. Here, a microfluidic method to prepare cell membrane sheets was developed as a promising tool for direct examination of the cytoplasmic faces of cell membranes. Mammalian cells immobilized on a poly(ethylene glycol)-lipid coated substrate were rapidly and efficiently fractured, with the sheer stress of laminar flow in microchannels, resulting in isolation of the bottom cell membrane sheets with exposed intact cytoplasmic faces...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29095175/orbital-floor-fractures
#7
Denise R Ramponi, Terri Astorino, Colleen R Bessetti-Barrett
The orbital bones are thin and exposed, making the orbital walls vulnerable to fractures. The floor of the orbit is the weakest portion of this 4-sided pyramid structure. Blunt force trauma is the primary mechanism of injury in young men between the ages of 18 and 30 years. Computerized tomography is the primary imaging technique to diagnose orbital fractures. Conservative versus surgical management is determined by maxillofacial and ophthalmology specialists.
October 2017: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/29094009/digital-blinding-of-radiographs-to-mask-allocation-in-a-randomized-control-trial
#8
Gerard P Slobogean, Lukasz Soswa, Giuliana Rotunno, Peter J O'Brien, Kelly A Lefaivre
AIM: To demonstrate the effectiveness of a digital radiographic altering technique in concealing treatment allocation to blind outcome assessment of distal femur fracture fixation. METHODS: Digital postoperative anteroposterior and lateral radiographs from a sample of 33 randomly-selected patients with extra-articular distal femur fractures treated by surgical fixation at a Level 1 trauma center were included. Using commercially available digital altering software, we devised a technique to blind the radiographs by overlaying black boxes over the implant hardware while preserving an exposed fracture site for assessment of fracture healing...
October 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/29079370/impact-of-an-emergency-medicine-pharmacist-on-initial-antibiotic-prophylaxis-for-open-fractures-in-trauma-patients
#9
Somer Harvey, A Brad Hall, Kayla Wilson
BACKGROUND: Targeted antibiotic treatment reduces the infection risk of open fractures when soft tissue and bone are exposed to the environment. The risk of infection increases with higher degrees of injury. The Gustilo-Anderson system was developed to identify the degree of injury of open fractures and can be utilized to guide initial antibiotic therapy. Few studies have been published evaluating the potential impact of emergency medicine pharmacists in trauma, and currently no study has evaluated a pharmacist's influence on antibiotic selection and timing for open fractures...
October 17, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29068496/effectiveness-of-oral-bisphosphonates-in-reducing-fracture-risk-among-oral-glucocorticoid-users-three-matched-cohort-analyses
#10
M Amine Amiche, Linda E Lévesque, Tara Gomes, Jonathan D Adachi, Suzanne M Cadarette
The benefit of oral bisphosphonates in reducing fracture risk among in glucocorticoid-induced osteoporosis is controversial. We aimed to estimate the effectiveness of oral bisphosphonates in reducing fracture risk in a cohort of new chronic oral glucocorticoid users. We created three matched cohorts using healthcare administrative data from Ontario, Canada. We included residents aged 66 years and older initiating chronic oral glucocorticoids (≥450 mg prednisone equivalent and ≥ 2 GC prescriptions within a 6-month window) between January 1998 and September 2014...
October 25, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29067126/early-surgery-increases-mitochondrial-dna-release-and-lung-injury-in-a-model-of-elderly-hip-fracture-and-chronic-obstructive-pulmonary-disease
#11
Jianzheng Zhang, Juan Wang, Xiaowei Wang, Zhi Liu, Jixin Ren, Tiansheng Sun
Hip fractures are one of the most common injuries in elderly individuals and are associated with a high incidence of complications and mortality. Clinical guidelines recommend early reparative surgery within 24-48 h from hospital admission; however, it is currently unknown whether this principle of early surgery is applicable for patients with hip fracture and chronic obstructive pulmonary disease (COPD). To investigate the systemic inflammatory response and lung injury as a result early surgery in elderly patients with hip fracture and COPD, a COPD model was created, by daily exposure to cigarette smoke, and evaluated...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29065039/opioid-prescribing-practices-by-orthopaedic-trauma-surgeons-after-isolated-femur-fractures
#12
Basem Attum, Andres Buitrago Rodriguez, Nichelle Harrison, Adam Evans, William Obremskey, Manish Sethi, Alex Jahangir
OBJECTIVE: The purpose of this retrospective study was to identify opioid prescribing practices, determine the number of morphine milliequivalents (MMEs) prescribed by orthopaedic/non-orthopaedic members to narcotic naive and previously exposed patients and provide narcotic prescribing recommendations. METHODS: Patients over 18 years old with an isolated femur fracture sustained between 2013 and 2015 were identified using the CPT code 27506. Prescribing information was obtained from the State Controlled Substance Monitoring Database (CSMD)...
October 14, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29062762/development-of-wheelchair-caster-testing-equipment-and-preliminary-testing-of-caster-models
#13
Anand Mhatre, Joseph Ott, Jonathan Pearlman
BACKGROUND: Because of the adverse environmental conditions present in less-resourced environments (LREs), the World Health Organization (WHO) has recommended that specialised wheelchair test methods may need to be developed to support product quality standards in these environments. A group of experts identified caster test methods as a high priority because of their common failure in LREs, and the insufficiency of existing test methods described in the International Organization for Standardization (ISO) Wheelchair Testing Standards (ISO 7176)...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/29057630/femur-fractures-in-parkinsonism-analysis-of-a-national-sample-cohort-in-south-korea
#14
Soo Jeong An, Seung Hwan Lee, Seo Young Lee, Jae Woo Kwon, Seung Joon Lee, Young Ju Kim
BACKGROUND AND PURPOSE: Falling with a femur fracture is a serious event that negatively affects the quality of life of elderly individuals as well as patients with parkinsonism. This study investigated the association between parkinsonism and femur fracture and compared the risk of femur fracture between subjects with and without parkinsonism. METHODS: This study examined a population-based matched cohort constructed using the National Sample Cohort data set, which comprises approximately one million subscribers to medical insurance and aid in South Korea...
October 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29056125/quantification-and-further-refinements-of-dorsal-metacarpal-artery-perforator-flap-for-reconstruction-of-wounds-of-fingers-upto-distal-interphalangeal-joints
#15
Muhammad Amin Yousaf, Zain Ul Abidin, Farrukh Aslam Khalid, Kamran Khalid, Muhammad Saleem, Muhammad Jibran Rabbani, Abdul Malik Mujahid, Moazzam Nazeer Tarrar
OBJECTIVE: To assess the outcome of dorsal metacarpal artery perforator flap for coverage of finger defects extending upto distal interphalangeal joint (DIPJ). STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Jinnah Burn and Reconstructive Surgery Centre, Lahore, from March 2015 to May 2017. METHODOLOGY: Our study was carried out in two parts. 1st part of study was to measure average flap length in our population...
October 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29042720/microtensile-bond-strength-and-failure-modes-of-flowable-composites-on-primary-dentin-with-application-of-different-adhesive-strategies
#16
Simge Durmuşlar, Ayşegül Ölmez
BACKGROUND: Resin composite is an option for the restoration of primary teeth, and new materials with simplified procedures are increasingly being suggested. AIMS: This study aims to evaluate the microtensile bond strengths and fracture modes of flowable composites on primary dentin with application of different adhesive strategies. MATERIALS AND METHODS: Sixty extracted noncaries primary molars were abraded from buccal surfaces to expose dentin surface...
July 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29038626/maxillofacial-injuries-in-women-a-retrospective-study-of-10%C3%A2-years
#17
Sudhir Ramisetty, Rajasekhar Gaddipati, Nandagopal Vura, Satheesh Pokala, Sheetal Kapse
INTRODUCTION: Diversities exists in incidence, etiology and epidemiology of facial fractures among male and female individuals due to various reasons. Many of the epidemiological studies published during the millennium have shown male predilection. This study was carried to evaluate the etiology, patterns and distribution of facial fractures among different age groups in women. MATERIALS AND METHODS: This Retrospective epidemiological study dealt with a total of 302 women with 422 fractures in maxillofacial region during a period of June 1st 2005 to May 31st 2015 at Mamata Dental College and Hospital, Khammam, Telangana, India...
December 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/29035725/alterations-to-juvenile-zebrafish-danio-rerio-swim-performance-after-acute-embryonic-exposure-to-sub-lethal-exposures-of-hydraulic-fracturing-flowback-and-produced-water
#18
Erik J Folkerts, Tamzin A Blewett, Yuhe He, Greg G Goss
Hydraulic fracturing flowback and produced water (FPW) is a wastewater produced during fracturing activities in an operating well which is hyper saline and chemically heterogeneous in nature, containing both anthropogenic and petrogenic chemicals. Determination of FPW associated toxicity to embryonic fish is limited, while investigation into how embryonic exposures may affect later life stages is not yet studied. Zebrafish embryos (24hrs post fertilization) were acutely exposed to 2.5% and 5% FPW fractions for either 24 or 48hrs and returned to freshwater...
October 7, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28991829/sepsis-reduces-bone-strength-before-morphologic-changes-are-identifiable
#19
Zudin A Puthucheary, Yao Sun, Kaiyang Zeng, Lien Hong Vu, Zhi Wei Zhang, Ryan Z L Lim, Nicholas S Y Chew, Matthew E Cove
OBJECTIVES: Survivors of critical illness have an increased prevalence of bone fractures. However, early changes in bone strength, and their relationship to structural changes, have not been described. We aimed to characterize early changes in bone functional properties in critical illness and their relationship to changes in bone structure, using a sepsis rodent model. DESIGN: Experimental study. SETTING: Animal research laboratory. SUBJECTS: Adult Sprague-Dawley rats...
December 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28985633/role-of-negative-pressure-therapy-as-damage-control-in-soft-tissue-reconstruction-for-open-tibial-fractures
#20
Mario Cherubino, Luigi Valdatta, Pierluigi Tos, Salvatore D'Arpa, Luigi Troisi, Pellegatta Igor, Federica Corradi, Umraz Khan
The concept of damage control orthopaedics (DCO) is a strategy that focuses on managing orthopaedic injuries in polytrauma patients who are in an unstable physiological state. The concept of DCO is an extension of damage control surgery or damage limitation surgery (DCS/DLS). Recently, it has become clear that certain patients, following extensive soft tissue trauma, could benefit from the idea of DCS. In the management of severe lower extremity trauma with exposed fracture sites, aggressive early wound excision debridement, early internal fixation, and vascularized wound coverage within a few days after trauma were proposed...
October 2017: Journal of Reconstructive Microsurgery
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