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https://www.readbyqxmd.com/read/28227454/importance-of-metabolism-variations-in-a-model-of-extracorporeal-carbon-dioxide-removal
#1
S Habran, Th Desaive, Ph Morimont, B Lambermont, P C Dauby, S Habran, T Desaive, Ph Morimont, B Lambermont, P C Dauby, S Habran, Th Desaive, B Lambermont, P C Dauby, Ph Morimont
Extracorporeal CO2 Removal device is used in clinics when a patient suffers from a pulmonary insufficiency like Acute Respiratory Distress Syndrome and allows to decarboxylate blood externally. In this work, a model of the respiratory system coupled with such a device is proposed to analyze the decrease of CO2 partial pressure in blood. To validate the model, some parameters are estimated thanks to experimental data. Metabolism is a crucial parameter and we show that its time evolution must be taken into account in order to have correct CO2 partial pressure simulations in arteries and in veins...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227447/non-invasive-monitoring-of-pulmonary-artery-pressure-at-the-bedside
#2
M Proenca, F Braun, E Muntane, J Sola, A Adler, M Lemay, J-Ph Thiran, S F Rimoldi, M Proenca, F Braun, E Muntane, J Sola, A Adler, M Lemay, J-Ph Thiran, S F Rimoldi, S F Rimoldi, E Muntane, J Sola, M Lemay, A Adler, J-Ph Thiran, F Braun
Current solutions for the monitoring of pulmonary artery pressure (PAP) in patients suffering from pulmonary hypertension are limited to invasive means. Non-invasive alternatives, such as Doppler echocardiography, are incompatible with continuous monitoring due to their dependency on qualified personnel to perform the measurements. In the present study, a novel non-invasive and unsupervised approach based on the use of electrical impedance tomography (EIT) is presented. The approach was evaluated in three healthy subjects undergoing hypoxia-induced variations in PAP...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227085/an-object-oriented-model-of-the-cardiopulmonary-system-with-emphasis-on-the-gravity-effect
#3
Chuong Ngo, Silvia Briones Herranz, Berno Misgeld, Thomas Vollmer, Steffen Leonhardt, Chuong Ngo, Silvia Briones Herranz, Berno Misgeld, Thomas Vollmer, Steffen Leonhardt, Thomas Vollmer, Steffen Leonhardt, Chuong Ngo, Berno Misgeld
We introduce a novel comprehensive model of the cardiopulmonary system with emphasis on perfusion and ventilation distribution along the vertical thorax axis under the gravity effect. By using an object-oriented environment, the complex physiological system can be represented by a network of electrical, lumped-element compartments. The lungs are divided into three zones: upper, middle, and lower zone. Blood flow increases with the distance from the apex to the base of the lungs. The upper zone is characterized by a complete collapse of the pulmonary capillary vasculature; thus, there is no flow in this zone...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226983/perspective-imaging-of-flow-in-arterial-model-obtained-with-continuous-wave-doppler-focusing-technique
#4
Ryo Nagaoka, Katsuhiro Sasaki, Seiichi Zama, Masaaki Nagone, Hiroshi Nagai, Yasuhito Takeuchi, Yoshifumi Saijo, Ryo Nagaoka, Katsuhiro Sasaki, Seiichi Zama, Masaaki Nagone, Hiroshi Nagai, Yasuhito Takeuchi, Yoshifumi Saijo, Yoshifumi Saijo, Hiroshi Nagai, Katsuhiro Sasaki, Masaaki Nagone, Seiichi Zama, Ryo Nagaoka, Yasuhito Takeuchi
Flowing emboli in the circulatory system cause fatal diseases such as stroke or pulmonary embolism. Conventional transcranial Doppler ultrasound for detection of emboli requires precise positioning by experienced examiner. In the present study, an easier emboli detection device by visualizing perspective view of blood vessel is proposed. The perspective image was obtained with continuous wave (CW) Doppler ultrasound from 2-dimensional array probe. CW Doppler signal from each element was focused by novel beam forming algorithm to obtain en face images at arbitrary depth to form perspective image...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224974/differences-in-outcomes-in-patients-with-stable-coronary-artery-disease-managed-by-cardiologists-versus-non-cardiologists-the-international-prospective-clarify-registry
#5
Zofia Parma, Philippe Gabriel Steg, Nicola Greenlaw, Roberto Ferrari, Ian Ford, Kim Fox, Jean-Claude Tardif, Joao Morais, Marco Alcocer Gamba, Stefan Kääb, Michał Tendera
INTRODUCTION    Clinical outcomes of patients with stable coronary artery disease (SCAD) may differ between those primarily managed by cardiologists versus non-cardiologists.  OBJECTIVES    Our main objective was to analyze the clinical outcomes of outpatients with SCAD in relation to the specialty of the managing physicians.  PATIENTS AND METHODS    We studied 32,468 outpatients with SCAD included in the CLARIFY registry, with up to 4 years follow-up data. Cardiologists provided medical care in 84...
January 20, 2017: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/28224928/impact-of-right-ventricular-function-on-outcome-of-severe-aortic-stenosis-patients-undergoing-transcatheter-aortic-valve-replacement
#6
Edward Koifman, Romain Didier, Nirav Patel, Zack Jerusalem, Sarkis Kiramijyan, Itsik Ben-Dor, Smita I Negi, Zuyue Wang, Steven A Goldstein, Michael J Lipinski, Rebecca Torguson, Jiaxiang Gai, Augusto D Pichard, Lowell F Satler, Ron Waksman, Federico M Asch
BACKGROUND: Right ventricular (RV) dysfunction was shown to be associated with adverse outcomes in a variety of cardiac patients and is considered a risk factor for adverse outcome according to the updated Valve Academic Research Consortium criteria. OBJECTIVE: Our goal was to assess the impact of RV function at baseline on 1-year mortality among patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). METHODS: All patients with severe AS treated with TAVR from May 2007 to March 2015 at our center were included in the present study, and baseline and procedural characteristics were recorded for each patient...
February 2017: American Heart Journal
https://www.readbyqxmd.com/read/28224110/comparison-of-inhaled-milrinone-nitric-oxide-and-prostacyclin-in-acute-respiratory-distress-syndrome
#7
Martin Albert, Daniel Corsilli, David R Williamson, Marc Brosseau, Patrick Bellemare, Stéphane Delisle, Anne Qn Nguyen, France Varin
AIM: To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome (ARDS). METHODS: Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of iNO (20 ppm) or nebulized epoprostenol (10 μg/mL) was done in all patients...
February 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28223154/idiopathic-and-systemic-sclerosis-associated-pulmonary-arterial-hypertension-a-comparison-of-demographic-haemodynamic-and-magnetic-resonance-imaging-characteristics-and-outcomes
#8
Sheila Ramjug, Nehal Hussain, Judith Hurdman, Catherine Billings, Athanasios Charampopoulos, Charlie A Elliot, David G Kiely, Ian Sabroe, Smitha Rajaram, Andrew J Swift, Robin Condliffe
BACKGROUND: Previous studies have identified survival in systemic sclerosis (SSc)-associated pulmonary arterial hypertension (SSc-PAH) to be worse than in idiopathic pulmonary arterial hypertension (IPAH). We investigated differences between these conditions by comparing demographic, haemodynamic and radiological characteristics and outcomes in a large cohort of incident patients. METHODS: 651 patients diagnosed with IPAH or SSc-associated pre-capillary pulmonary hypertension were included...
February 18, 2017: Chest
https://www.readbyqxmd.com/read/28221717/cerebral-and-lung-effects-of-a-new-generation-synthetic-surfactant-with-sp-b-and-sp-c-analogs-in-preterm-lambs
#9
Carmen Rey-Santano, Victoria E Mielgo, Xabier Murgia, Miguel Angel Gomez-Solaetxe, Fabrizio Salomone, Federico Bianco, Nicola Pelizzi, Begoña Loureiro, Jon López de Heredia Y Goya
BACKGROUND: Though natural surfactants (SF) are clinically superior to protein-free synthetic preparations, CHF-5633, a synthetic SF containing SP-B and SP-C analog peptides is a potential alternative to natural SF for treating neonatal respiratory distress syndrome (RDS). Nevertheless, information is lacking regarding the safety of this new treatment for the neonatal brain. We sought to compare the cerebral and pulmonary effects of this new synthetic surfactant (CHF5633) with those of natural porcine surfactant (Cursosurf) in premature lambs with RDS...
February 21, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28221263/use-of-model-based-iterative-reconstruction-to-improve-detection-of-congenital-cardiovascular-anomalies-in-infants-undergoing-free-breathing-computed-tomographic-angiography
#10
Seth Kligerman, Ferdia Bolster, Jason Mitchell, Travis Henry, Jean Jeudy, Charles S White
PURPOSE: The aim of the study was to assess the detection of congenital cardiovascular anomalies (congenital heart disease) in neonates and infants using model-based iterative reconstruction (MBIR) algorithm compared with hybrid iterative reconstruction (HIR) and filtered back projection (FBP) reconstructions on axial computed tomography (CT) performed at minimum scanner dose. MATERIALS AND METHODS: Over 1 year, all CT angiographies performed in infants below 3 months of age with congenital heart disease were assessed retrospectively...
March 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28219895/impact-of-practice-based-management-of-pa-pressures-in-2000-patients-implanted-with-the-cardiomems-sensor
#11
J Thomas Heywood, Rita Jermyn, David Shavelle, William T Abraham, Arvind Bhimaraj, Kunjan Bhatt, Fareed Sheikh, Eric Eichorn, Sumant Lamba, Rupinder Bharmi, Rahul Agarwal, Charisma Kumar, Lynne W Stevenson
Background -Elevated pulmonary artery (PA) pressures in patients with heart failure (HF) are associated with a high risk for hospitalization and mortality. Recent clinical trial evidence demonstrated a direct relationship between lowering remotely monitored PA pressures and HF hospitalization risk reduction using a novel implantable PA pressure monitoring system (CardioMEMS HF System, St Jude Medical). This study examines PA pressure changes in the first 2,000 US patients implanted in general practice use. Methods -De-identified data from the remote monitoring Merlin...
February 20, 2017: Circulation
https://www.readbyqxmd.com/read/28219851/understanding-the-requirements-of-self-expandable-stents-for-heart-valve-replacement-radial-force-hoop-force-and-equilibrium
#12
María Sol Cabrera, Cees W J Oomens, Frank P T Baaijens
A proper interpretation of the forces developed during stent crimping and deployment is of paramount importance for a better understanding of the requirements for successful heart valve replacement. The present study combines experimental and computational methods to assess the performance of a nitinol stent for tissue-engineered heart valve implantation. To validate the stent model, the mechanical response to parallel plate compression and radial crimping was evaluated experimentally. Finite element simulations showed good agreement with the experimental findings...
February 7, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28219567/contraceptive-implant-embolism-into-the-pulmonary-artery-thoracoscopic-retrieval
#13
Pascal A Thomas, Donatella Di Stefano, Cécile Couteau, Xavier Benoît D'Journo
An 18-year old woman had migration of a subdermal contraceptive implant in a subsegmental branch of her left lower lobe pulmonary artery. She was managed successfully through a conservative surgical approach, as the implant was removed from the pulmonary artery thoracoscopically, thereby avoiding the need of thoracotomy or lung resection.
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28219564/coronary-artery-fistulae-involving-both-right-and-left-coronary-arteries
#14
Ahmet Bolukcu, Ahmet Can Topcu, Yavuz Sensoz, Ilyas Kayacioglu
A coronary artery fistula is defined as an abnormal direct communication between any coronary artery and any of the cardiac chambers, superior vena cava, coronary sinus, pulmonary artery, and pulmonary veins. The right coronary artery (RCA) is the most common site of origin, and right heart chambers are the most common site of drainage. However, there are few cases reported in the literature in which the fistulae originate from both the right coronary and the left anterior descending arteries and drain into the pulmonary artery...
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28218352/concomitant-pulsatile-and-continuous-flow-vad-in-biventricular-and-univentricular-physiology-a-comparison-study-with-a-numerical-model
#15
Arianna Di Molfetta, Gianfranco Ferrari, Roberta Iacobelli, Sergio Filippelli, Paolo Guccione, Libera Fresiello, Gianluigi Perri, Antonio Amodeo
INTRODUCTION: To develop and test a lumped parameter model to simulate and compare the effects of the simultaneous use of continuous flow (CF) and pulsatile flow (PF) ventricular assist devices (VADs) to assist biventricular circulation vs. single ventricle circulation in pediatrics. METHODS: Baseline data of 5 patients with biventricular circulation eligible for LVAD and of 5 patients with Fontan physiology were retrospectively collected and used to simulate patient baselines...
February 11, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28218213/surgical-treatment-of-double-outlet-right-ventricle-complicated-by-pulmonary-hypertension
#16
Qing-Yu Wu, Dong-Hai Li, Hong-Yin Li, Ming-Kui Zhang, Zhong-Hua Xu, Hui Xue
BACKGROUND: Double outlet right ventricle (DORV) is a group of complex congenital heart abnormalities. Preoperative pulmonary hypertension (PH) is considered an important risk factor for early death during the surgical treatment of DORV. The aim of this study was to report our experience on surgical treatment of DORV complicated by PH. METHODS: From June 2004 to November 2016, 61 patients (36 males and 25 females) aged 2 weeks to 26 years (median: 0.67 years and interquartile range: 0...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28218209/clinical-study-of-acute-vasoreactivity-testing-in-patients-with-chronic-thromboembolic-pulmonary-hypertension
#17
Qi-Xia Xu, Yuan-Hua Yang, Jie Geng, Zhen-Guo Zhai, Juan-Ni Gong, Ji-Feng Li, Xiao Tang, Chen Wang
BACKGROUND: The clinical significance of acute vasoreactivity testing (AVT) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) remains unclear. We analyzed changes in hemodynamics and oxygenation dynamics indices after AVT in patients with CTEPH using patients with pulmonary arterial hypertension (PAH) as controls. METHODS: We analyzed retrospectively the results of AVT in 80 patients with PAH and 175 patients with CTEPH registered in the research database of Beijing Chao-Yang Hospital between October 2005 and August 2014...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28217807/-role-of-trpc6-in-pulmonary-artery-smooth-muscle-cells-proliferation-and-apoptosis-under-hypoxia-and-hypercapnia
#18
Xu-Guang Jia, Meng-Xiao Zheng, Jing-Jing Zhang, Cong-Cong Zhang, Mei-Ping Zhao, Yi-Ming Wu, Xi-Wen Chen, Wan-Tie Wang
The present study was to investigate the role of TRPC6 in pulmonary artery smooth muscle cells (PASMCs) proliferation and apoptosis under hypoxia and hypercapnia. PASMCs were isolated from chloral hydrate-anesthetized male Sprague-Dawley (SD) rats. Cellular purity was assessed by immunofluorescence staining for smooth muscle α-actin under fluorescence microscopy. Passage 4-6 PASMCs were starved for 24 h in serum-free DMEM and divided into 5 groups randomly: normoxia, hypoxia and hypercapnia, DMSO, TRPC6 inhibitor SKF-96365 and TRPC6 activator OAG groups...
February 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28217802/-comparison-of-agonists-induced-contraction-between-main-and-the-third-order-branches-of-pulmonary-arteries-in-rats
#19
Qiu-Hong Huang, Yun-Ping Mu, Fu-Rong Yan, Jie-Ling Zhu, Xiao-Ru Liu, Mo-Jun Lin
This study was designed to observe the differences between main pulmonary arteries and the third-order branches of pulmonary arteries in the contractile response to phenylephrine (Phen), endothelin-1 (ET-1) and potassium chloride (KCl). The vascular tension changes of main and the third-order branches of pulmonary arteries induced by KCl, ET-1 and Phen were recorded by traditional vascular tone detection methods and microvascular ring technique, respectively. The results showed that Phen could cause a significant contraction in main pulmonary arteries, but did not induce apparent contraction in the third-order branches of pulmonary arteries...
February 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28217618/recurrent-first-trimester-abortion-in-a-young-female-rare-presentation-of-takayasu-arteritis
#20
Suruchi Gupta, Puneet Chhabra, Nikhil Gupta, Parul Aggarwal
Takayasu arteritis (TA) is a chronic, progressive, autoimmune, idiopathic, and large-vessel vasculitis that usually affects young adults, especially females. TA primarily affects the aorta and its major branches, the coronary arteries, and the pulmonary arteries. Recurrent pregnancy loss is usually defined as three or more consecutive losses occurring at <20 weeks' gestation of a clinically recognized pregnancy. Common causes of recurrent fetal loss include anatomic, chromosomal, hormonal, infectious, or antiphospholipid antibody syndrome...
July 2016: Journal of Family Medicine and Primary Care
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