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https://www.readbyqxmd.com/read/29917301/prevalence-and-prognostic-impact-of-non-cardiac-co-morbidities-in-heart-failure-outpatients-with-preserved-and-reduced-ejection-fraction-a-community-based-study
#1
Annamaria Iorio, Michele Senni, Giulia Barbati, Stephen J Greene, Stefano Poli, Elena Zambon, Concetta Di Nora, Giovanni Cioffi, Luigi Tarantini, Antonello Gavazzi, Gianfranco Sinagra, Andrea Di Lenarda
AIM: To assess adverse outcomes attributable to non-cardiac co-morbidities and to compare their effects by left ventricular ejection fraction (LVEF) group [LVEF <50% (heart failure with reduced ejection fraction, HFrEF), LVEF ≥50% (heart failure with preserved ejection fraction, HFpEF)] in a contemporary, unselected chronic heart failure population. METHODS AND RESULTS: This community-based cohort enrolled patients from October 2009 to December 2013. Adjusted hazard ratio (HR) and the population attributable fraction (PAF) were used to compare the contribution of 15 non-cardiac co-morbidities to adverse outcome...
June 19, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29917290/hypoxic-pulmonary-vasoconstriction-in-isolated-mouse-pulmonary-arterial-vessels
#2
Ievgen Strielkov, Nicole Catherine Krause, Natasha Sommer, Ralph Theo Schermuly, Hossein Ardeschir Ghofrani, Friedrich Grimminger, Thomas Gudermann, Alexander Dietrich, Norbert Weissmann
NEW FINDINGS: What is the central question of this study? Hypoxic pulmonary vasoconstriction has never been characterized in isolated mouse pulmonary arteries of different generations in detail. What is the main finding and its importance? We found that only small intrapulmonary arteries (80 - 200 μm in diameter) exhibit hypoxic pulmonary vasoconstriction. The observed response was sustained, significantly potentiated by depolarization-induced preconstriction, and not dependent on endothelium and TRPC6 channels...
June 19, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29916558/increased-right-atrial-volume-measured-with-cardiac-magnetic-resonance-is-associated-with-worse-clinical-outcome-in-patients-with-pre-capillary-pulmonary-hypertension
#3
Anna Bredfelt, Göran Rådegran, Roger Hesselstrand, Håkan Arheden, Ellen Ostenfeld
AIMS: Pre-capillary pulmonary hypertension (PHpre-cap ) has a poor prognosis, especially when caused by pulmonary arterial hypertension (PAH) associated with systemic sclerosis (SSc-PAH). Whether cardiac magnetic resonance (CMR)-based quantification of atrial volumes in PHpre-cap is beneficial in risk assessment is unknown. The aims were to investigate if (i) atrial volumes using CMR are associated with death or lung transplantation in PHpre-cap , (ii) atrial volumes differ among four unmatched major PHpre-cap subgroups, and (iii) atrial volumes differ between SSc-PAH and idiopathic/familial PAH (IPAH/FPAH) when matched for pulmonary vascular resistance (PVR)...
June 19, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29916259/polymorphisms-c677t-and-a1298c-of-mthfr-gene-homocysteine-levels-and-prothrombotic-biomarkers-in-coronary-and-pulmonary-thromboembolic-disease
#4
Eulo Lupi-Herrera, María Elena Soto-López, Antonio de Jesús Lugo-Dimas, Marcela Elizabeth Núñez-Martínez, Ricardo Gamboa, Claudia Huesca-Gómez, Lilia Mercedes Sierra-Galán, Verónica Guarner-Lans
The activity of the enzyme methylenetetrahydrofolate reductase (MTHFR) determines homocysteine (Hcy) levels, and polymorphisms in its gene affect the activity of the enzyme. Changes in the enzyme's activity may lead to a higher susceptibility to develop arterial and venous thromboembolic disease. The aim was to analyze the relationship between the C677T and A1298C polymorphisms of MTHFR, Hcy levels, and prothrombotic biomarkers in pulmonary embolism (PE) and acute myocardial ischemia (AMI). Clinical files of patients with thromboembolic diseases having complete data and whose doctor had requested an assay to determine the polymorphisms of the MTHFR gene, Hcy levels, and prothrombotic biomarkers were studied to search for the correlation between mutations of the MTHFR gene and Hcy levels in the different diseases...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29915795/saddle-pulmonary-embolus-resulting-in-cardiovascular-collapse-requiring-extracorporeal-membrane-oxygenation-in-a-postoperative-patient-with-endometrial-cancer
#5
David Samuel, Gregory M Gressel, Sara Isani, Akiva P Novetsky, Nicole S Nevadunsky
Background: Venous thromboembolism after open gynecologic surgery is not uncommon, especially in the presence of other risk factors such as obesity, prolonged surgical time or gynecologic malignancy. Case: We present the case of a 62 y.o. patient who underwent open hysterectomy and surgical staging for uterine serous carcinoma. She was readmitted with lower extremity edema. During her workup, she underwent cardiovascular arrest secondary to saddle pulmonary embolus requiring cardiopulmonary resuscitation and extracorporeal membrane oxygenation...
May 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29915733/prevalence-of-pulmonary-artery-hypertension-in-patients-of-chronic-obstructive-pulmonary-disease-and-its-correlation-with-stages-of-chronic-obstructive-pulmonary-disease-exercising-capacity-and-quality-of-life
#6
Kamlesh Kumar Gupta, Bidyut Roy, Shyam Chand Chaudhary, Arvind Mishra, M L Patel, Jitendra Singh, Vivek Kumar
Background: Pulmonary arterial hypertension (PAH) is a complication of chronic obstructive pulmonary disease (COPD) in advance stages, and its presence indicates poor prognosis. Aims and Objective: The present study was design to know the prevalence of PAH in patients with COPD and its correlation with stages of COPD, exercising capacity, and quality of life. Materials and Methods: It is a cross-sectional prevalence study over a period of 1 year from August 2015 to July 2016...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915694/histology-of-24-organs-from-asian-elephant-calves-elephas-maximus
#7
Chatchote Thitaram, Pitchaya Matchimakul, Wanpitak Pongkan, Wasan Tangphokhanon, Raktham Maktrirat, Jaruwan Khonmee, Anucha Sathanawongs, Piyamat Kongtueng, Korakot Nganvongpanit
Background: Elephants are the largest and heaviest living terrestrial animals, but information on their histology is still lacking. This study provides a unique insight into the elephant's organs and also provides a comparison between juvenile Asian elephants and adult Asian elephants or other species. Here we report on the histological structure of 24 organs, including the skin, brain (cerebrum, cerebellar hemisphere, vermis, thalamus, midbrain), spinal cord, sciatic nerve, striated skeletal muscle, cardiac muscle, bone (flat bone and long bone), cartilage (hyaline cartilage and fibrocartilage), heart (right atrium, right ventricle), blood vessels (aorta, pulmonary artery and caudal vena cava), trunk, trachea, lung, tongue, esophagus, stomach, small intestine (duodenum, jejunum, ileum), large intestine (cecum, colon, rectum), liver and pancreas, kidney, ovary, uterus (body and horn) and spleen of two juvenile Asian elephants...
2018: PeerJ
https://www.readbyqxmd.com/read/29914536/very-late-presentation-of-anomalous-origin-of-the-left-coronary-artery-from-the-pulmonary-artery-case-report
#8
Pairoj Chattranukulchai, Jule Namchaisiri, Monravee Tumkosit, Sarinya Puwanant, Yongkasem Vorasettakarnkij, Suphot Srimahachota, Smonporn Boonyaratavej
BACKGROUND: Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital coronary anomaly. The enlarged right coronary artery provides retrograde collaterals to supply the left ventricle then preferentially directs into the lower pressure pulmonary artery system causing coronary steal phenomenon. Few patients who survive through adulthood without surgery must have abundant, well-formed functioning collaterals with adequate perfusion of the left ventricle...
June 18, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29913536/hemostasis-in-the-very-young
#9
Gili Kenet, Assaf Arie Barg, Ulrike Nowak-Göttl
Hemostasis is a dynamic process that starts in utero. The coagulation system evolves with age, as evidenced by marked physiological differences in the concentration of the majority of hemostatic proteins in early life compared with adulthood. This concept, known as "developmental hemostasis," has important biological and clinical implications. Overall, impaired platelet function, along with physiologically reduced levels of vitamin K-dependent and contact coagulation factors, may cause poorer clot firmness even in healthy neonates...
June 18, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29913136/mmp-2-and-mmp-9-contribute-to-the-angiogenic-effect-produced-by-hypoxia-15-hete-in-pulmonary-endothelial-cells
#10
Ying Liu, Hongyue Zhang, Lixin Yan, Wei Du, Min Zhang, He Chen, Lixin Zhang, Guangqun Li, Jijin Li, Yinchu Dong, Daling Zhu
Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are the predominant gelatinases in the developing lung. Studies have shown that the expression of MMP-2 and MMP-9 is upregulated in hypoxic fibroblasts, 15-hydroxyeicosatetraenoic acid (15-HETE) regulated fibroblasts migration via modulating MMP-2 or MMP-9, and that hypoxia/15-HETE is a predominant contributor to the development of pulmonary arterial hypertension (PAH) through increased angiogenesis. However, the roles of MMP-2 and MMP-9 in pulmonary arterial endothelial cells (PAECs) angiogenesis as well as the molecular mechanism of hypoxia-regulated MMP-2 and MMP-9 expression have not been identified...
June 15, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29913126/the-evolution-of-therapeutic-strategies-niche-apportionment-for-hybrid-palliation
#11
REVIEW
Christoph Haller, Christopher A Caldarone
Hybrid palliation, the concept to stabilize univentricular circulation with bilateral pulmonary artery banding and maintenance of ductal patency, has significantly widened the therapeutic spectrum for patients with single ventricle malformations or borderline hypoplasia. Although the concept has already been a part of early attempts to improve outcome in hypoplastic left heart syndrome, it has not attracted much attention initially. Technical refinement and expertise have led to results that ultimately allowed the palliative strategy to gain traction and to be selectively adopted...
June 15, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29912937/comparison-of-three-non-invasive-hemodynamic-monitoring-methods-in-critically-ill-children
#12
Chanapai Chaiyakulsil, Marut Chantra, Poomiporn Katanyuwong, Anant Khositseth, Nattachai Anantasit
INTRODUCTION: Hemodynamic parameters measurements were widely conducted using pulmonary artery catheter (PAC) with thermodilution as a reference standard. Due to its technical difficulties in children, transthoracic echocardiography (TTE) has been widely employed instead. Nonetheless, TTE requires expertise and is time-consuming. Noninvasive cardiac output monitoring such as ultrasonic cardiac output monitor (USCOM) and electrical velocimetry (EV) can be performed rapidly with less expertise requirement...
2018: PloS One
https://www.readbyqxmd.com/read/29912741/predictors-of-persistent-tricuspid-regurgitation-after-transcatheter-aortic-valve-replacement-in-patients-with-baseline-tricuspid-regurgitation
#13
Berhane Worku, Marie-Therese Valovska, Adham Elmously, Polydoros Kampaktsis, Catherine Castillo, Shing-Chiu Wong, Arash Salemi
OBJECTIVE: This study sought to analyze outcomes in patients with moderate-severe tricuspid regurgitation (TR) undergoing transcatheter aortic valve replacement (TAVR). The consequences of uncorrected significant TR in patients undergoing TAVR remain undefined. METHODS: Between 2009 and 2014, 369 patients underwent TAVR at our institution, and 58 of these had baseline moderate-severe TR. Preoperative, 30-day, and 1-year transthoracic echocardiograms were analyzed...
June 15, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29912400/reinforcing-the-pulmonary-artery-autograft-in-the-aortic-position-with-a-textile-mesh-a-histological-evaluation
#14
Emma Vanderveken, Julie Vastmans, Tom Verbelen, Peter Verbrugghe, Nele Famaey, Eric Verbeken, Tom Treasure, Filip Rega
OBJECTIVES: The Ross procedure involves replacing a patient's diseased aortic valve with their own pulmonary valve. The most common failure mode is dilatation of the autograft. Various strategies to reinforce the autograft have been proposed. Personalized external aortic root support has been shown to be effective in stabilizing the aortic root in Marfan patients. In this study, the use of a similar external mesh to support a pulmonary artery autograft was evaluated. METHODS: The pulmonary artery was translocated as an interposition autograft in the descending thoracic aortas of 10 sheep...
April 17, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29911492/nocturnal-hypoventilation-may-have-a-protective-effect-for-ischemic-heart-disease-in-obesity-hypoventilation-syndrome
#15
Giorgio Castellana, Silvano Dragonieri, Lorenzo Marra, Vitaliano Quaranta, Pierluigi Carratù, Teresa Ranieri, Onofrio Resta
BACKGROUND: The importance of nocturnal hypoventilation in the development of cardiovascular comorbidity (CVM) in patients with Obesity Hypoventilation Syndrome (OHS) is controversial. We recently hypothesized that nocturnal hypoventilation may have a protective effect on cardiovascular comorbidity in OHS. AIM: The aim of this study was to evaluate the link between nocturnal hypoventilation (nHyp) and CVM in patients with OHS. METHODS: We performed a retrospective analysis of the clinical records of 60 patients with OHS...
June 18, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29911388/reimplantation-of-an-anomalous-left-coronary-artery-with-a-malignant-course
#16
Yutaka Imoto, Tomoyuki Matsuba, Hideaki Kanda, Yuki Ogata, Shuji Nagatomi, Kentaro Ueno
A 14-year-old boy was diagnosed with an anomalous left coronary artery coursing between the ascending aorta and the main pulmonary artery and associated with a single coronary ostium. Owing to the high risk of sudden cardiac death, surgery was performed although he was asymptomatic with no sign of myocardial ischemia. Reimplantation of an anomalous left coronary artery is generally considered difficult because an aortic cuff is unavailable for coronary anastomosis; however, we accomplished a successful direct reimplantation in this patient...
January 1, 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29911011/successful-retrieval-of-a-migrated-shunt-catheter-causing-severe-pulmonary-insufficiency
#17
Shunsuke Aoi, Gabriele Di Luozzo, Gianluca Torregrossa, Dennis Finkielstein
We report a case of a woman who presented with worsening shortness of breath due to a migrated ventriculoatrial shunt catheter into the pulmonary artery causing severe pulmonary insufficiency. She underwent surgical catheter removal. The majority of the catheter was easily retrieved; however, there were areas where the catheter was embedded into the myocardium, which would have posed a challenge with an endovascular approach.
April 2018: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29911007/elevated-mean-pulmonary-artery-pressure-and-right-ventricular-dysfunction-in-children-with-chronic-kidney-disease
#18
Igoche D Peter, Mustafa O Asani, Ibrahim Aliyu, Patience N Obiagwu
Background: Elevated mean pulmonary artery pressure (mPAP) and right heart failure increase mortality in patients with chronic kidney disease (CKD). Objectives: The objective of this study is to determine the prevalence of elevated mPAP in children with CKD compared with matched controls and to ascertain the relationship between elevated mPAP with right ventricular dysfunction and history of hemodialysis. Materials and Methods: A cross-sectional comparative study of mPAP and tricuspid annular plane systolic excursion of 21 children with CKD and age- and sex-matched controls asymptomatic for cardiac disease was conducted...
April 2018: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29910735/switching-off-adora2b-in-vascular-smooth-muscle-cells-halts-the-development-of-pulmonary-hypertension
#19
Tinne C J Mertens, Ankit Hanmandlu, Ly Tu, Carole Phan, Scott D Collum, Ning-Yuan Chen, Tingting Weng, Jonathan Davies, Chen Liu, Holger K Eltzschig, Soma S K Jyothula, Keshava Rajagopal, Yang Xia, Ashrith Guha, Brian A Bruckner, Michael R Blackburn, Christophe Guignabert, Harry Karmouty-Quintana
Background: Pulmonary hypertension (PH) is a devastating and progressive disease characterized by excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) and remodeling of the lung vasculature. Adenosine signaling through the ADORA2B receptor has previously been implicated in disease progression and tissue remodeling in chronic lung disease. In experimental models of PH associated with chronic lung injury, pharmacological or genetic inhibition of ADORA2B improved markers of chronic lung injury and hallmarks of PH...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29910057/the-prevalence-of-pulmonary-arterial-hypertension-before-and-after-atrial-septal-defect-closure-at-adult-age-a-systematic-review
#20
REVIEW
Roxanne D Zwijnenburg, Vivan J M Baggen, Laurie W Geenen, Kelly R Voigt, Jolien W Roos-Hesselink, Annemien E van den Bosch
BACKGROUND: The development or persistence of pulmonary arterial hypertension (PAH) after atrial septal defect (ASD) closure at adult age is associated with a poor prognosis. The objective of this review was to investigate the prevalence of PAH before and after ASD closure and to identify factors that are associated with PAH. METHODS: EMBASE and MEDLINE databases were searched for publications until March 2017. All studies reporting the prevalence of PAH or data on pulmonary artery pressures both before and after surgical or percutaneous ASD closure in an adult population (≥16 years of age) were included...
July 2018: American Heart Journal
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