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Hong Yan, Furong Wang, Lin Xiang, Wei Zhu, Cheng Liang
RATIONALE: Diffuse giant cell tumors of the tendon sheath (GCT-TS) in the temporomandibular joint (TMJ) are extremely rare. PATIENT CONCERNS: We reported the imaging appearance and the pathological findings of 2 male cases with diffuse GCT-TS in the TMJ (52 years for the case 1 and 50 years for the case 2) who complain of the hearing disorders of left ear when presenting to our hospital. DIAGNOSIS: Preoperative computerized tomography (CT) scan revealed an irregular mass in the left temporal fossa with the sizes of approximately 5...
June 2018: Medicine (Baltimore)
Sean M Stainton, Kamilia Abdelraouf, Luke Utley, Michael J Pucci, Troy Lister, David P Nicolau
SPR741 is a novel agent with structural similarity to polymyxins, capable of potentiating the activity of various classes of antibiotics. Previously published studies indicated that although Enterobacteriacae isolates had minimal susceptibilities to azithromycin (AZM), the in vitro antimicrobial activity of AZM against Enterobacteriacae was enhanced when combined with SPR741. The current study evaluated the in vivo activity of human-simulated regimens (HSR) of AZM equivalent to clinical doses of 500 mg IV q24h and SPR741 400 mg q8h IV (1h infusion) alone and in combination against multi-drug resistant (MDR) Enterobacteriacae...
June 18, 2018: Antimicrobial Agents and Chemotherapy
Zhengyang Chen, Shufeng Yang, Jingshe Li, Hao Guo, Hongbo Zheng
Hot working is a key process in the production of superalloys; however, it may result in the formation of inclusions that affect the superalloy performance. Therefore, the effects of hot working on inclusions in a superalloy must be studied. GH4738 superalloy was manufactured, herein, by vacuum induction melting and vacuum arc remelting. Hot working was performed by unidirectional drawing, upsetting and drawing, and upsetting/drawing with radial forging. The types and distributions of inclusions after these three hot working processes and those in an original ingot were analyzed using scanning electron microscopy, energy dispersive spectroscopy, and Image-Pro Plus software...
June 15, 2018: Materials
Masafumi Hirato, Takaaki Miyagishima, Akio Takahashi, Yuhei Yoshimoto
OBJECTIVE: Long-term effectiveness of selective ventralis intermedius (VIM)-ventralis oralis (VO) thalamotomy with depth microrecording for the treatment of focal dystonia was evaluated. The optimal thalamic areas for controlling focal dystonia were studied based on the electrophysiological and anatomical data. METHODS: Stereotactic selective VIM-VO thalamotomy with depth microrecording was carried out in 8 patients with focal arm and hand dystonia and in one patient with cervical dystonia...
June 14, 2018: World Neurosurgery
Shabbir Hussain Merchant, Sheng-Han Kuo, Yu Qiping, Linda Winfield, Guy McKhann, Sameer Sheth, Seth L Pullman, Blair Ford
OBJECTIVE: To identify pre-operative clinical and computerized spiral analysis characteristics that may help ascertain which patients with Essential Tremor (ET) will exhibit 'early tolerance' to ventral intermediate nucleus of thalamus (Vim) deep brain stimulation (DBS). METHODS: Identification of comparative characteristics of defined cases of 'early tolerance' versus patients with sustained satisfactory response treated with Vim DBS surgery for medically-refractory ET, based on retrospective chart review by a clinician blinded to the findings of computerized spiral analysis...
June 5, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Vicente Martinez, Shu-Ching Hu, Thomas J Foutz, Andew Ko
Holmes tremor (HT) is a rare movement disorder that is typically associated with cerebellar, thalamic or brainstem lesions following a delay. Treatment of HT with deep brain stimulation (DBS) has yielded positive results however; it is unclear which deep brain targets provide optimal therapeutic effects. Here we describe a case report in which a 34 year old man with HT treated successfully with DBS. The ventrointermediate nucleus (VIM) of the thalamus was considered as the initial target. Following electrode placement we determined that the ventral-most electrode contacts were located in the prelemniscal radiations (Raprl)...
2018: Frontiers in Surgery
A Rezaei, H Fazeli, M Halaji, M Moghadampour, J Faghri
INTRODUCTION: The emergence of Metallo-beta-lactamase (MBL)-producing Acinetobacter baumannii has become a global concern in nosocomial infections. The aim of this study is to determine the prevalence of MBL producing genes among clinical isolates of A. baumannii from hospitalized patients. METHODS: This study was performed from October 2015 to October 2016 at three teaching hospitals located in Isfahan, Iran. Totally, 100 A-baumannii isolates were collected from clinical specimens and identified as A-baumannii using standard microbiological methods...
July 2018: Annali di Igiene: Medicina Preventiva e di Comunità
Hai Lin, Xiao-Dong Cai, Dou-Dou Zhang, Jia-Li Liu, Wei-Ping Li
BACKGROUND: Primary dystonia is a neurological disease with the characteristics of abnormal, involuntary twisting and turning movements, which greatly affects life quality of patients. Treatments for dystonia consist of oral medications, botulinum neurotoxin injections, physical therapy and surgeries. For medication-refractory dystonia, surgeries, especially deep brain stimulation (DBS), are the optimal option. CASE DESCRIPTION: the patient was a 13-year-old boy suffering from extremely severe primary dystonia, with a BFMDRS-M score of 118 and a TWSTRS-S score of 29...
June 8, 2018: World Neurosurgery
Abdol Ahad Dogonchi, Ezzat Allah Ghaemi, Abdollah Ardebili, Sajjad Yazdansetad, Abazar Pournajaf
Objective: Carbapenems are effective agents to treat multidrug-resistant (MDR) strains of bacteria, including Pseudomonas aeruginosa . However, there is a potential threat of emergence of carbapenem-resistant P. aeruginosa (CRPA). The aim of this study was to determine antibiotic susceptibility patterns and metallo-beta-lactamase (MBL)-mediated resistance in clinical P. aeruginosa isolates. Materials and Methods: Different clinical specimens were subjected to conventional culture-based identification of P...
April 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
Xu Yan, Yu Yu, Lingyu Li, Naifei Chen, Wei Song, Hua He, Jie Dong, Xiangliang Liu, Jiuwei Cui
Breast cancer is the most common cancer in women worldwide; despite the developments in diagnosis and therapy, recurrence and metastasis remain the main causes of death among patients with breast cancer. This study aimed to identify a promising biomarker for this disease. The study clarified (1) the association between Friend leukemia virus integration 1 (FLI-1) and various molecular subtypes and (2) the prognostic value of FLI-1 in breast cancer. To the best of our knowledge, this study is the first to report that FLI-1 is a predictor of poor prognosis in patients with breast cancer and overexpressed in the triple negative breast cancer (TNBC) subtype...
June 4, 2018: Cancer Medicine
María E Pachón-Ibáñez, Gema Labrador-Herrera, Tania Cebrero-Cangueiro, Caridad Díaz, Younes Smani, José P Del Palacio, Jesús Rodríguez-Baño, Alvaro Pascual, Jerónimo Pachón, M Carmen Conejo
Despite the relevance of carbapenemase-producing Klebsiella pneumoniae (CP-Kp) infections there are a scarce number of studies to evaluate in vivo the efficacy of combinations therapies. The bactericidal activity of colistin, rifampin, and its combination was studied (time-kill curves) against four clonally unrelated clinical isolates of CP-Kp, producing VIM-1, VIM-1 plus DHA-1(acquired AmpC β-lactamase), OXA-48 plus CTX-M-15 (extended spectrum β-lactamase) and KPC-3, respectively, with colistin MICs of 0...
2018: Frontiers in Microbiology
Carlotta Raschioni, Giulia Bottai, Andrea Sagona, Valentina Errico, Alberto Testori, Wolfgang Gatzemeier, Fabio Corsi, Corrado Tinterri, Massimo Roncalli, Libero Santarpia, Luca Di Tommaso
Luminal B breast cancers (BC) have a more aggressive behavior associated with a higher rate of tumor relapse and worse prognosis compared to luminal A tumors. In this study, we evaluated the involvement of specific epithelial-to-mesenchymal transition- (EMT-) and immune-related pathways in the dissemination of luminal B BC cells. The expression of 42 EMT- and immune-related genes was evaluated in matched sentinel lymph nodes (SLNs) analyzed by the one-step nucleic acid amplification assay (OSNA) and primary tumors of 40 luminal B BC patients by gene array and immunohistochemistry...
2018: Disease Markers
Maria M Traczewski, Edoardo Carretto, Rafael Canton, Nicholas M Moore
This multicenter study evaluated the performance of the Cepheid Xpert® Carba-R assay, a qualitative PCR test designed for rapid detection of bla KPC, bla NDM, bla VIM, bla IMP, and bla OXA-48 carbapenem resistance genes from bacterial isolates grown on blood agar or MacConkey agar. The results were compared to those obtained from bidirectional DNA sequence analysis of nucleic acid extracted from pure colonies. Isolates of Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii that tested as either intermediate or resistant to a carbapenem antibiotic were included...
May 30, 2018: Journal of Clinical Microbiology
Chuansha Gu, Xiaoyan Wang, Ting Long, Xia Wang, Yan Zhong, Yidan Ma, Zhiyan Hu, Zuguo Li
Follistatin-like protein 1 (FSTL1) has been reported to have both tumour-promoting and tumour-suppressive characters. However, the role of FSTL1 in colorectal cancer (CRC) remains unclear. Here we showed that FSTL1 expression was significantly up-regulated in CRC tissues compared with the paired normal tissues. In addition, the higher FSTL1 expression was associated with the infiltrating depth, lymph node metastasis and poor prognosis of CRC. Enhanced expression of FSTL1 distinctly increased cell migration and invasion in vitro, as well as promoting liver metastasis of CRC in vivo...
May 29, 2018: Cell Death & Disease
Bao Guan, Yunchao Xing, Gengyan Xiong, Zhenpeng Cao, Dong Fang, Yifan Li, Yonghao Zhan, Ding Peng, Libo Liu, Xuesong Li, Liqun Zhou
The clinical relevance of aberrant DNA promoter methylation is being increasingly recognized in urothelial carcinoma. The present study was conducted to explore the methylation status of patients with upper-tract urothelial carcinoma (UTUC) who experienced bladder recurrence, and to evaluate the predictive value of gene methylation for second bladder recurrence and tumor progression. A total of 85 patients with primary UTUC, who experienced bladder recurrence after radical nephroureterectomy, were enrolled between January 2001 and December 2013...
June 2018: Oncology Letters
Giulia Errico, Carlo Gagliotti, Monica Monaco, Lucia Masiero, Paolo Gaibani, Simone Ambretti, Maria Paola Landini, Silvia D'Arezzo, Antonino Di Caro, Saverio Giuseppe Parisi, Giorgio Palù, Francesca Vespasiano, Filomena Morsillo, Maria Luisa Moro, Francesco Procaccio, Andrea Ricci, Paolo Antonio Grossi, Annalisa Pantosti, Alessandro Nanni Costa
OBJECTIVE: A prospective cohort study was conducted in Italy in order to describe the microbiological aspects of colonization/infection by carbapenemase producing Enterobacteriaceae (CPE) in donors and recipients of lung and liver transplants and the possible CPE transmission from donors to recipients. METHODS: Between 15 January 2014-14 January 2015 all recipients of solid organ transplants (SOT) at 10 lung and 8 liver transplantation centres (TCs) and the corresponding donors were enrolled...
May 22, 2018: Clinical Microbiology and Infection
Jie Ding, Chiuan-Ren Yeh, Yin Sun, Changyi Lin, Joshua Chou, Zhenyu Ou, Chawnshang Chang, Jun Qi, Shuyuan Yeh
Recent studies indicated that the estrogen receptor beta (ERβ) could affect the progression of prostate and bladder tumors, however, its roles in the renal cell carcinoma (RCC), remain to be elucidated. Here, we provide clinical evidence that ERβ expression is correlated in a negative manner with the overall survival/disease-free survival in RCC patients. Mechanism dissection revealed that targeting ERβ with ERβ-shRNA and stimulating the transactivation of ERβ with 17β-estradiol or environmental endocrine disrupting chemicals, all resulted in altering the lncRNA HOTAIR expression...
May 23, 2018: Oncogene
Ming Tang, Xu Cao, Kun Zhang, You Li, Quan-You Zheng, Gui-Qing Li, Qian-Hui He, Shu-Jing Li, Gui-Lian Xu, Ke-Qin Zhang
Renal fibrosis is the final manifestation of various chronic kidney diseases, and no effective therapy is available to prevent or reverse it. Celastrol, a triterpene that derived from traditional Chinese medicine, is a known potent anti-fibrotic agent. However, the underlying mechanisms of action of celastrol on renal fibrosis remain unknown. In this study, we found that celastrol treatment remarkably attenuated unilateral ureteral obstruction (UUO)-induced mouse renal fibrosis. This was evidenced by the significant reduction in tubular injury; collagen deposition; accumulation of fibronectin, collagen I, and α-smooth muscle actin; and the expression levels of pro-fibrotic factors Vim, Cola1, and TGF-β1 mRNA, as well as inflammatory responses...
May 22, 2018: Cell Death & Disease
Marianne Lund, Marianne Bøgild Petersen, Anders Lægaard Jørgensen, Dorte Paulmann, Mikala Wang
An in-house real-time PCR was developed to detect the carbapenemase genes IMP, NDM, VIM, KPC and OXA-48 from both bacterial colonies and directly from fecal material. The assay is a multiplex PCR performed in two tubes with NDM, VIM and IMP genes detected in one tube and OXA-48 and KPC genes in the other. Despite the large amount of primers and probes necessary to cover all variants of especially the VIM and IMP genes, the efficiency of the PCR reactions was from 95 to 100%. When tested on 170 clinical strains and compared to culture results from a reference laboratory, 100% correspondence was found...
April 13, 2018: Diagnostic Microbiology and Infectious Disease
Saeed Shams, Ali Hashemi, Mohammad Esmkhani, Somaye Kermani, Elham Shams, Alessandra Piccirillo
OBJECTIVE: The emergence of metallo-β-lactamase-producing Enterobacteriaceae is a worldwide health concern. In this study, the first evaluation of MBL genes, bla IMP and bla VIM , in Escherichia coli resistant to imipenem isolated from urine and blood specimens in Qom, Iran is described. Three hundred urine and blood specimens were analysed to detect the presence of E. coli. Resistance to imipenem and other antimicrobials was determined by disk diffusion and MIC. MBL production was screened using CDDT...
May 18, 2018: BMC Research Notes
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