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https://www.readbyqxmd.com/read/29659796/dissemination-of-multi-resistant-gram-negative-bacteria-into-german-wastewater-and-surface-waters
#1
Heike Müller, Esther Sib, Mike Gajdiss, Ursula Klanke, Franziska Lenz-Plet, Vanessa Barabasch, Cathrin Albert, Anna Schallenberg, Christian Timm, Nicole Zacharias, Ricarda Maria Schmithausen, Steffen Engelhart, Martin Exner, Marijo Parcina, Christiane Schreiber, Gabriele Bierbaum
Carbapenem antibiotics constitute the mainstay therapy of nosocomial infections with ESBL (extended spectrum beta-lactamase) producing Gram-negative bacteria, however, resistance against these compounds is increasing. This study was designed to demonstrate that carbapenemase-producing bacteria are disseminated from hospitals into the environment. To this end, resistant bacteria were isolated from a clinical/urban and from a rural catchment system in Germany in 2016/17. The study followed the dissemination of resistant bacteria from the wastewater through the wastewater treatment plant into the receiving surface waters...
April 6, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29659494/deep-brain-stimulation-of-the-subthalamic-nucleus-in-patients-with-parkinson-disease-with-prior-pallidotomy-or-thalamotomy
#2
Elena A Khabarova, Natalia P Denisova, Aleksandr B Dmitriev, Konstantin V Slavin, Leo Verhagen Metman
Objective. To evaluate the efficacy of deep brain stimulation of the subthalamic nucleus (STN DBS) in patients with Parkinson disease (PD) who previously underwent lesioning of the basal ganglia. Material and methods. The study included 22 patients who underwent STN DBS. Eleven patients had undergone prior unilateral pallidotomy ( n = 6) or VL/VIM thalamotomy ( n = 5) while the other 11 patients had not. The primary outcome was the change from baseline in the motor subscore of the Unified Parkinson Disease Rating Scale (UPDRS-III) 12 months after STN DBS...
April 16, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29657957/the-effect-of-deep-brain-stimulation-therapy-on-fear-related-capture-of-attention-in-parkinson-s-disease-and-essential-tremor-a-comparison-to-healthy-individuals
#3
Corrie R Camalier, Maureen McHugo, David H Zald, Joseph S Neimat
In addition to motor symptoms, Parkinson's disease (PD) involves significant non-motor sequelae, including disruptions in cognitive and emotional processing. Fear recognition appears to be affected both by the course of the disease and by a common interventional therapy, deep brain stimulation of the subthalamic nucleus (STN-DBS). Here, we examined if these effects extend to other aspects of emotional processing, such as attentional capture by negative emotional stimuli. Performance on an emotional attentional blink (EAB) paradigm, a common paradigm used to study emotional capture of attention, was examined in a cohort of individuals with PD, both on and off STN-DBS therapy (n=20)...
2018: Journal of Neurological Disorders
https://www.readbyqxmd.com/read/29656793/long-noncoding-rna-vim-as1-promotes-colorectal-cancer-progression-and-metastasis-by-inducing-emt
#4
Hajar Rezanejad Bardaji, Malek Hossein Asadi, Mohammad Mehdi Yaghoobi
Emerging evidence indicates that lncRNAs play crucial roles in the initiation and progression of various malignant tumors. VIM-AS1 RNA is an lncRNA that transcribes from a shared bidirectional promoter with vimentin mRNA and its function in cancer cells is largely unknown. This study assessed the clinical significance of VIM-AS1 expression in colorectal cancer (CRC). We found that the VIM-AS1 transcript was significantly upregulated in high-grade, lymph node metastasis and vascular invasion tumors. Loss-of-function experiments revealed that the downregulation of VIM-AS1 could inhibit tumor cell proliferation by inducing apoptosis, cellular senescence and arresting the cell cycle...
April 7, 2018: European Journal of Cell Biology
https://www.readbyqxmd.com/read/29649276/carbapenem-resistant-gram-negative-pathogens-in-a-german-university-medical-center-prevalence-clinical-implications-and-the-role-of-novel-%C3%AE-lactam-%C3%AE-lactamase-inhibitor-combinations
#5
Juri Katchanov, Lucia Asar, Eva-Maria Klupp, Anna Both, Camilla Rothe, Christina König, Holger Rohde, Stefan Kluge, Florian P Maurer
OBJECTIVES: To determine the spectrum of infections with multidrug-resistant Gram-negative bacteria (MDR-GNB) and the clinical impact of the newly available betalactam/betalactamase inhibitor combinations ceftolozane/tazobactam and ceftazidime/avibactam in a German academic tertiary care center. METHODS: Retrospective analysis. RESULTS: Between September 1, 2015 and August 31, 2016, 119 individual patients (0.22% of all hospital admissions) were colonized or infected with carbapenem-resistant MDR-GNB...
2018: PloS One
https://www.readbyqxmd.com/read/29644540/molecular-epidemiology-of-carbapenem-resistant-pseudomonas-aeruginosa-in-an-endemic-area-comparison-with-global-data
#6
REVIEW
Theodoros Karampatakis, Charalampos Antachopoulos, Athanassios Tsakris, Emmanuel Roilides
Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is an endemic problem in certain countries including Greece. CRPA and multidrug-resistant P. aeruginosa (MDRPA) firstly emerged in our region during the 80s, right after the launch of imipenem and meropenem as therapeutic agents against P. aeruginosa infections. The role of outer membrane protein (Opr) inactivation has been known to contribute to imipenem resistance since many years, while efflux overexpression systems have been mainly associated with meropenem resistance...
April 11, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29642473/resistance-to-carbapenems-in-non-typhoidal-salmonella-enterica-serovars-from-humans-animals-and-food
#7
REVIEW
Javier Fernández, Beatriz Guerra, M Rosario Rodicio
Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial drug resistance in different settings. Of particular concern is the resistance to critical "last resort" antimicrobials, such as carbapenems. In contrast to other Enterobacteriaceae (e.g., Klebsiella pneumoniae , Escherichia coli , and Enterobacter , which are major nosocomial pathogens affecting debilitated and immunocompromised patients), carbapenem resistance is still very rare in NTS...
April 8, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29621591/bacteraemia-due-to-extensively-drug-resistant-pseudomonas-aeruginosa-sequence-type-235-high-risk-clone-facing-the-perfect-storm
#8
Raúl Recio, Jennifer Villa, Esther Viedma, María Ángeles Orellana, Jaime Lora-Tamayo, Fernando Chaves
Predictors of mortality and the impact of multidrug resistance and virulence on patients with Pseudomonas aeruginosa (PA) bacteraemia were evaluated. Patients with PA bacteraemia in a 12-month period were retrospectively analysed. Carbapenemase production, molecular typing and identification of virulence factor ExoU were carried out. The activity of ceftolozane-tazobactam and ceftazidime-avibactam was also investigated. The primary endpoint was 30-day crude mortality. Of 64 patients with bacteraemia, 24 (37...
April 2, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29620207/calotropin-regulates-the-apoptosis-of-non%C3%A2-small-cell-cancer-by-regulating-the-cytotoxic-t%C3%A2-lymphocyte-associated-antigen-4%C3%A2-mediated-tgf%C3%A2-%C3%AE-erk-signaling-pathway
#9
Lu Tian, Xiao-Hong Xie, Ze-Hao Zhu
Non‑small‑cell lung cancer (NSCLC) is one of the most common malignancies that is responsible for a high level of cancer‑associated mortalities worldwide. Previous evidence has shown that Calotropin is an upstream activator of protein kinase B, which can further inhibit the growth and promote the apoptosis of NSCLC cells. In the present study, the efficacy of Calotropin on growth, aggressiveness and apoptosis of NSCLC cells was investigated, as well as the potential underlying mechanism. The results demonstrated that Calotropin inhibited H358 cell growth, migration and invasion...
April 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29600395/deep-brain-stimulation-of-the-thalamic-ventral-intermediate-nucleus-for-benedikt-s-syndrome-mainly-present-as-tremor-a-long-term-case-observation
#10
Guoxiong Cheng, Yuan Yang, Yuelong Wang, Hongyu Tan, Shizhen Zhang
Benedikt's syndrome (BS) is caused by the lesion in the midbrain and specifically manifests a series of symptoms, including ipsilateral third nerve palsy, contralateral tremor, hemiataxia, and hyperactive tendon reflexes. Deep brain stimulation (DBS) for BS emerges as a new approach and achieves successfully results. We report a successful case report of thalamic ventral intermediate (VIM) nucleus DBS for a patient with BS. During follow-up of 3 years, DBS successfully control the tremor and greatly improve his living and working quality...
March 30, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29593911/first-report-of-bla-ctx-m-28-in-enterobacteriaceae-isolates-in-the-united-arab-emirates
#11
Mubarak Alfaresi, Garwin Kim Sing, Abiola Senok
Background: The CTX-M family of extended-spectrum beta lactamase (ESBL) enzymes is comprised of over 60 bla CTX-M gene variants with the predominance of bla CTX-M-15 in many regions. In this report, we present the first description of bla CTX-M-28 in the United Arab Emirates. Methods: Forty-five non-duplicate ESBL producing isolates identified in a secondary care facility in the United Arab Emirates from June to July 2016 were studied. Gene sequencing was performed and DNA sequences were annotated using the BLAST program to identify the gene subtypes...
2018: Journal of Pathogens
https://www.readbyqxmd.com/read/29593094/distinct-human-%C3%AE-1-3-fucosyltransferases-drive-lewis-x-sialyl-lewis-x-assembly-in-human-cells
#12
Nandini Mondal, Brad Dykstra, Jungmin Lee, David Ashline, Vernon N Reinhold, Derrick J Rossi, Robert Sackstein
In humans, six α(1,3)-fucosyltransferases (α(1,3)-FTs: FT3/FT4/FT5/FT6/FT7/FT9) reportedly fucosylate terminal lactosaminyl glycans yielding Lewis X (LeX ; CD15) and/or sialyl Lewis X (sLeX ; CD15s), structures that play key functions in cell migration, development, and immunity. Prior studies analyzing α(1,3)-FT-specificities utilized either purified and/or recombinant enzymes to modify synthetic substrates under non-physiological reaction conditions or molecular biology approaches wherein α(1,3)-FTs were expressed in mammalian cell lines, notably excluding investigations using primary human cells...
March 28, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29587262/whole-genome-linkage-analysis-with-whole-exome-sequencing-identifies-a-novel-frameshift-variant-in-nefh-in-a-chinese-family-with-charcot-marie-tooth-2-a-novel-variant-in-nefh-for-charcot-marie-tooth-2
#13
Xianli Bian, Pengfei Lin, Jiangxia Li, Feng Long, Ruonan Duan, Qianqian Yuan, Yan Li, Fei Gao, Shang Gao, Shijun Wei, Xi Li, Wenjie Sun, Yaoqin Gong, Chuanzhu Yan, Qiji Liu
BACKGROUND: Charcot-Marie-Tooth disease (CMT) is the most common neurodegenerative disorder of the peripheral nervous system. More than 50 genes/loci were found associated with the disease. We found a family with autosomal-dominant CMT2. OBJECTIVE: To reveal the pathogenic gene of the family and further investigate the function of the variant. METHODS: DNA underwent whole-genome linkage analysis for all family members and whole-exome sequencing for 2 affected members...
March 27, 2018: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/29579287/prospective-tractography-based-targeting-for-improved-safety-of-focused-ultrasound-thalamotomy
#14
Vibhor Krishna, Francesco Sammartino, Punit Agrawal, Barbara K Changizi, Eric Bourekas, Michael V Knopp, Ali Rezai
BACKGROUND: Focused ultrasound thalamotomy (FUS-T) was recently approved for the treatment of refractory essential tremor (ET). Despite its noninvasive approach, FUS-T reinitiated concerns about the adverse effects and long-term efficacy after lesioning. OBJECTIVE: To prospectively assess the outcomes of FUS-T in 10 ET patients using tractography-based targeting of the ventral intermediate nucleus (VIM). METHODS: VIM was identified at the intercommissural plane based on its neighboring tracts: the pyramidal tract and medial lemniscus...
March 21, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29575185/identification-of-vim-2-metallo-%C3%AE-lactamase-producing-pseudomonas-aeruginosa-isolated-from-dogs-with-pyoderma-and-otitis-in-korea
#15
Jae-Eun Hyun, Tae-Ho Chung, Cheol-Yong Hwang
BACKGROUND: Pseudomonas aeruginosa is a challenging pathogen cultured from cases of acute and chronic canine otitis and sometimes in cases of deep pyoderma. The spread of antimicrobial resistance, especially carbapenem resistance, is a serious therapeutic challenge worldwide. HYPOTHESIS/OBJECTIVES: To investigate the identification and characterization of resistant P. aeruginosa clinical canine isolates. MATERIALS: Clinical isolates (n = 80) were collected from dogs with pyoderma (n = 18) and otitis (n = 62) in Korea...
March 25, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29571838/multidrug-resistant-infections-in-long-term-care-facilities-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-and-hypervirulent-antibiotic-resistant-clostridium-difficile
#16
Maria Giufrè, Marisa Accogli, Enrico Ricchizzi, Fabrizio Barbanti, Claudio Farina, Paolo Fazii, Romano Mattei, Mario Sarti, Agostino Barozzi, Rossella Buttazzi, Marina Cosentino, Maria Nardone, Vincenzo Savini, Patrizia Spigaglia, Maria Luisa Moro, Marina Cerquetti
Infections due to multidrug-resistant (MDR) organisms in long-term care facilities (LTCFs) residents constitute a public health concern. This multicenter study investigated the frequency of ESBL-producing pathogens and MDR Clostridium difficile in clinical specimens from LTCF residents in Italy. During October 2014-March 2015, all urine and diarrheic fecal samples from LTCF residents (≥65 years) with suspected urinary tract infection or C. difficile infection, respectively, received for diagnosis by 4 hospital laboratories located in different cities were analyzed...
February 26, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29568429/intramolecular-substitution-uncages-fluorogenic-probes-for-detection-of-metallo-carbapenemase-expressing-bacteria
#17
Aiguo Song, Yunfeng Cheng, Jinghang Xie, Niaz Banaei, Jianghong Rao
This work reports a novel caging strategy for designing fluorogenic probes to detect the activity of β-lactamases. The caging strategy uses a thiophenyl linker connected to a fluorophore caged by a good leaving group-dinitrophenyl. The uncaging proceeds in two steps through the sulfa-releasing and subsequent intramolecular substitution. The length of the linker has been examined and optimized to maximize the rate of intramolecular reaction and thus the rate of fluorescence activation. Finally based on this strategy, we prepared a green fluorogenic probe CAT-7 and validated its selectivity for detecting metallo-carbapenemases (VIM-27, IMP-1, NDM-1) in carbapenem-resistant Enterobacteriaceae (CRE) lysates...
November 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29564870/-nosocomial-infections-caused-by-multiresistant-pseudomonas-aeruginosa-carbapenems-included-predictive-and-prognostic-factors-a-prospective-study-2016-2017
#18
A Hernández, G Yagüe, E García Vázquez, M Simón, L Moreno Parrado, M Canteras, J Gómez
OBJECTIVE: Pseudomonas aeruginosa is one of the major pathogens causing hospital-acquired infections. In recent years, antimicrobial resistance is increasing and multidrug resistant (MDR) and extremely drug resistant (XDR) isolates have been associated with an increase of mortality. The aim of this study is to assess the clinical significance and analyze predictors and prognostic factors. METHODS: Prospective case-control non-paired study involving 64 patients with P...
March 21, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29554578/occurrence-of-thalamic-high-frequency-oscillations-in-patients-with-different-tremor-syndromes
#19
Sarah Schnitzler, Christian Johannes Hartmann, Stefan Jun Groiss, Lars Wojtecki, Alfons Schnitzler, Jan Vesper, Jan Hirschmann
OBJECTIVE: To assess whether high frequency oscillations (HFOs, >150 Hz), known to occur in basal ganglia nuclei, can be observed in the thalamus. METHODS: We recorded intraoperative local field potentials from the ventral intermediate nucleus (VIM) of the thalamus in patients with Essential Tremor (N = 16), Parkinsonian Tremor (3), Holmes Tremor (2) and Dystonic Tremor (1) during implantation of electrodes for deep brain stimulation. Recordings were performed with up to five micro/macro-electrodes that were simultaneously advanced to the stereotactic target...
February 19, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29551437/antimicrobial-susceptibility-and-characterization-of-metallo-%C3%AE-lactamases-extended-spectrum-%C3%AE-lactamases-and-carbapenemases-of-bacillus-cereus-isolates
#20
Karmen Godič Torkar, Branka Bedenić
The susceptibility of 66 clinical and environmental B. cereus isolates were tested to selected antimicrobials by a broth microdilution method. All strains were resistant to β-lactams and susceptible to gentamicin and imipenem. Sixty-five (98.5%) isolates were susceptible to meropenem and ciprofloxacin and 74.2% to azithromycin. Significant differences in MIC values between environmental and clinical isolates were not demonstrated (p > 0.05). According to the disc diffusion method, 80.3%-98.5% of the strains were resistant to one or more of four cephalosporins...
March 15, 2018: Microbial Pathogenesis
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