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https://www.readbyqxmd.com/read/29466423/proteomic-analysis-of-the-human-retina-reveals-region-specific-susceptibilities-to-metabolic-and-oxidative-stress-related-diseases
#1
Gabriel Velez, Daniel A Machlab, Peter H Tang, Yang Sun, Stephen H Tsang, Alexander G Bassuk, Vinit B Mahajan
Differences in regional protein expression within the human retina may explain molecular predisposition of specific regions to ophthalmic diseases like age-related macular degeneration, cystoid macular edema, retinitis pigmentosa, and diabetic retinopathy. To quantify protein levels in the human retina and identify patterns of differentially-expressed proteins, we collected foveomacular, juxta-macular, and peripheral retina punch biopsies from healthy donor eyes and analyzed protein content by liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
2018: PloS One
https://www.readbyqxmd.com/read/29464320/comparative-immunohistochemical-characterization-of-interstitial-cells-in-the-urinary-bladder-of-human-guinea-pig-and-pig
#2
Clara Steiner, Thomas Gevaert, Roman Ganzer, Dirk De Ridder, Jochen Neuhaus
Interstitial cells (ICs) are thought to play a functional role in urinary bladder. Animal models are commonly used to elucidate bladder physiology and pathophysiology. However, inter-species comparative studies on ICs are rare. We therefore analyzed ICs and their distribution in the upper lamina propria (ULP), the deeper lamina propria (DLP) and the detrusor muscular layer (DET) of human, guinea pig (GP) and pig. Paraffin slices were examined by immunohistochemistry and 3D confocal immunofluorescence of the mesenchymal intermediate filament vimentin (VIM), alpha-smooth muscle actin (αSMA), platelet-derived growth factor receptor alpha (PDGFRα) and transient receptor potential cation channel A1 (TRPA1)...
February 20, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29462209/modulation-of-the-colon-cancer-cell-phenotype-by-pro-inflammatory-macrophages-a-preclinical-model-of-surgery-associated-inflammation-and-tumor-recurrence
#3
María Marcuello, Xavier Mayol, Eloísa Felipe-Fumero, Jaume Costa, Laia López-Hierro, Silvia Salvans, Sandra Alonso, Marta Pascual, Luís Grande, Miguel Pera
Peritoneal infection after colorectal cancer surgery is associated with a higher rate of tumor relapse. We have recently proposed that soluble inflammatory factors released in response to a postoperative infection enhance tumor progression features in residual tumor cells. In an effort to set up models to study the mechanisms of residual tumor cell activation during surgery-associated inflammation, we have analyzed the phenotypic response of colon cancer cell lines to the paracrine effects of THP-1 and U937 differentiated human macrophages, which release an inflammatory medium characteristic of an innate immune response...
2018: PloS One
https://www.readbyqxmd.com/read/29457437/-clinical-application-value-of-mri-on-malignant-fibrous-histiocytoma-in-soft-tissue
#4
Wan-Li Xu, Xiao Wu, Hai-Feng Qian, Dong Liu
OBJECTIVE: To investigate imaging manifestation and clinical application of MRI on malignant fibrous histiocytoma (MFH) in soft tissue. METHODS: Imaging and pathological data of 16 patients with malignant fibrous histiocytoma (MFH) in soft tissue confirmed by surgery and pathology were retrospectively analyzed from January 2009 to August 2016. There were 9 males and 7 females, aged from 34 to 67 years old with an average of 52 years. The courses of disease ranged from 5 to 48 months with an average of 27 months...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29453319/leptin-signaling-mediates-obesity-associated-csc-enrichment-and-emt-in-preclinical-tnbc-models
#5
Laura W Bowers, Emily L Rossi, Shannon B McDonell, Steven S Doerstling, Subreen A Khatib, Claire G Lineberger, Jody E Albright, Xiaohu Tang, Linda A deGraffenried, Stephen D Hursting
Obesity is associated with poor prognosis in triple-negative breast cancer (TNBC). Preclinical models of TNBC were used to test the hypothesis that increased leptin signaling drives obesity-associated TNBC development by promoting cancer stem cell (CSC) enrichment and/or epithelial-to-mesenchymal transition (EMT). MMTV-Wnt-1 transgenic mice, which develop spontaneous basal-like, triple-negative mammary tumors, received either a control diet (10% kcal from fat) or a diet-induced obesity regimen (DIO, 60% kcal from fat) for up to 42 weeks (n=15/group)...
February 16, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29451428/extended-spectrum-%C3%AE-lactamase-ampc-and-mbl-producing-gram-negative-bacteria-on-fresh-vegetables-and-ready-to-eat-salads-sold-in-local-markets
#6
Ramona Iseppi, Simona de Niederhäusern, Moreno Bondi, Patrizia Messi, Carla Sabia
We investigated the occurrence of extended-spectrum β-lactamase (ESBL), AmpC, and carbapenemase-producing Gram-negative bacteria isolated from 160 samples of fresh vegetables (n = 80) and ready-to-eat (RTE) prepacked salads (n = 80). Phenotypic and genotypic analyses were carried out on the isolates in terms of the species present and relative resistance. Resistance to β-lactam antibiotics was found in only 44 (24 from fresh vegetables and 20 from RTE salads) of a total of 312 Gram-negative strains (14.1%)...
February 16, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29451087/multiple-imputation-with-sequential-penalized-regression
#7
Faisal M Zahid, Christian Heumann
Missing data is a common issue that can cause problems in estimation and inference in biomedical, epidemiological and social research. Multiple imputation is an increasingly popular approach for handling missing data. In case of a large number of covariates with missing data, existing multiple imputation software packages may not work properly and often produce errors. We propose a multiple imputation algorithm called mispr based on sequential penalized regression models. Each variable with missing values is assumed to have a different distributional form and is imputed with its own imputation model using the ridge penalty...
January 1, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29444761/chronic-infection-sustained-by-a-pseudomonas-aeruginosa-high-risk-clone-producing-the-vim-1-metallo-%C3%AE-lactamase-in-a-cystic-fibrosis-patient-after-lung-transplantation
#8
Simona Pollini, Claudia Mugnaioli, Daniela Dolce, Silvia Campana, Anna Silvia Neri, Giovanni Taccetti, Gian Maria Rossolini
BACKGROUND: The significance of chronic lung infection by multidrug-resistant (MDR) pathogens in Cystic Fibrosis (CF) transplanted patients remains controversial, and the available information is overall limited. Here we describe the case of a chronic infection, sustained by a metallo-β-lactamase (MBL)-producing P. aeruginosa strain, in a CF patient following lung transplantation. METHODS: Twelve P. aeruginosa isolates collected from a CF patient over a 15-years follow-up period after lung transplantation were analysed for their antibiotic susceptibility profile, MBL production and clonal relatedness...
February 12, 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29438045/double-target-dbs-for-essential-tremor-8-contact-lead-for-czi-and-vim-aligned-in-the-same-trajectory
#9
Maria Gabriela Dos Santos Ghilardi, Melisa Ibarra, Eduardo J L Alho, Paul Rodrigo Reis, William Omar Lopez Contreras, Clement Hamani, Erich Talamoni Fonoff
No abstract text is available yet for this article.
February 7, 2018: Neurology
https://www.readbyqxmd.com/read/29433124/thalamic-deep-brain-stimulation-salvages-failed-focused-ultrasound-thalamotomy-for-essential-tremor-a-case-report
#10
Tony R Wang, Robert F Dallapiazza, Shayan Moosa, Diane Huss, Binit B Shah, W Jeffrey Elias
BACKGROUND: A recent randomized controlled trial investigating unilateral MRI-guided focused ultrasound (FUS) for essential tremor demonstrated efficacy. The long-term durability of this thalamotomy, however, is unknown. Furthermore, the feasibility of stimulating a previously lesioned target such as the thalamic nucleus ventralis intermedius (Vim) is poorly understood. We report a case of tremor recurrence, following an initially successful FUS thalamotomy, in which Vim-DBS was subsequently utilized to regain tremor control...
February 12, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29432937/detection-of-vim-2-imp-1-and-ndm-1-producing-multidrug-resistant-pseudomonas-aeruginosa-in-malaysia
#11
Siew Mun Liew, Ganeswrei Rajasekaram, Savithri D Puthucheary, Kek Heng Chua
OBJECTIVES: The increasing incidence of carbapenem-resistant Pseudomonas aeruginosa along with the discovery of novel metallo-β-lactamases (MBLs) is of concern. In this study, the isolation of Malaysian MBL-producing P. aeruginosa clinical strains was investigated. METHODS: Fifty-three P. aeruginosa clinical strains were isolated from different patients in Sultanah Aminah Hospital, Johor Bahru, Malaysia in 2015. Antimicrobial susceptibility test was conducted. Minimum inhibitory concentrations (MICs) of imipenem and meropenem were determined by Etest...
February 9, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29421796/variability-in-predialysis-systolic-blood-pressure-and-long-term-outcomes-in-hemodialysis-patients
#12
Ying Wang, Yan Qin, Xiaohong Fan, Jianfang Cai, Wei Ye, Jinghua Xia, Mingxi Li, Xuemei Li, Xuewang Li, Limeng Chen
BACKGROUND/AIMS: While systolic blood pressure variability (SBPV) is an independent risk factor for mortality in the general population, its association with outcomes in hemodialysis patients has been less well-investigated. METHODS: In this retrospective study, we enrolled 99 eligible HD patients from 2006 to 2016. Predialysis blood pressure measurements obtained over 1-year period were used to determine each patient's BPV. The standard deviation (SD), the coefficient of variation (CV) and the variation independent of the mean (VIM) were used as metrics of BPV...
January 31, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29416932/long-noncoding-rna-cnalptc1-promotes-cell-proliferation-and-migration-of-papillary-thyroid-cancer-via-sponging-mir-30-family
#13
Cunrong Chen, Lili Zhou, Hui Wang, Junnian Chen, Wen Li, Wei Liu, Mingjie Shen, Hongzhou Liu, Xiaomin Fu
Several somatic copy number variations (CNVs) have been identified in papillary thyroid cancer (PTC). However, the functional roles of CNVs and the genes responsible for the roles of CNVs are largely unknown. In this study, we identified a novel long noncoding RNA (lncRNA) CNALPTC1 (copy number amplified long noncoding RNA in papillary thyroid cancer 1). The genomic copy number of CNALPTC1 is amplified and CNALPTC1 expression level is up-regulated in PTC. Increased expression of CNALPTC1 is associated with aggressive clinicopathological characteristics...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29414819/dbstar-an-open-source-tool-kit-for-imaging-analysis-with-patient-customized-deep-brain-stimulation-platforms
#14
Peter M Lauro, Shane Lee, Minkyu Ahn, Andrei Barborica, Wael F Asaad
BACKGROUND/OBJECTIVES: To create an open-source method for reconstructing microelectrode recording (MER) and deep brain stimulation (DBS) electrode coordinates along multiple parallel trajectories with patient-specific DBS implantation platforms to facilitate DBS research. METHODS: We combined the surgical geometry (extracted from WayPoint Planner), pre-/intra-/postoperative computed tomography (CT) and/or magnetic resonance (MR) images, and integrated them into the Analysis of Functional NeuroImages (AFNI) neuroimaging analysis environment using functions written in Python...
February 7, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29412174/whole-genome-sequencing-enabled-the-detection-of-a-colistin-resistant-hypermutating-citrobacter-werkmanii-strain-harbouring-a-novel-metallo-beta-lactamase-vim-48
#15
S Peter, D Bezdan, P Oberhettinger, W Vogel, D Dörfel, J Dick, M Marschal, J Liese, C Weidenmaier, I Autenrieth, S Ossowski, M Willmann
Citrobacter species harbouring metallo-beta-lactamases (MBLs) have been reported from various countries and different sources, but their isolation from clinical specimens remains a rare event in Europe. MBL-harbouring Enterobacteriaceae are considered a major threat in infection control as therapeutic options are often limited to colistin. In this study, we applied whole genome sequencing to characterize five clinical isolates of multidrug-resistant Citrobacter werkmanii obtained from rectal swabs. Four strains possessed a class I integron with a novel blaVIM-48 MBL-resistance gene and the aminoglycoside acetyltransferase gene aacA4, while one isolate harboured a blaIMP-8 MBL...
February 2, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29408817/prelemniscal-lesion-for-selective-improvement-of-parkinson-disease-tremor
#16
Francisco Velasco, Mauricio Esqueda-Liquidano, Ana Luisa Velasco, Maria Guadalupe García-Gomar
BACKGROUND: Selective improvement of symptoms may be required when treating Parkinson disease (PD) patients with a predominantly monosymptomatic clinical picture. OBJECTIVE: To define a target in prelemniscal radiation fibers (Raprl) related to the physiopathology of tremor evidenced by tractography. CASE REPORT: We report a patient with predominant unilateral rest and postural tremor, diagnosed as PD based on 80% improvement induced by the administration of L-DOPA/carbidopa, subsequently complicated by motor fluctuations, L-DOPA dyskinesia, and a reduced ON period...
February 6, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29404647/-essential-tremor-state-of-the-art
#17
REVIEW
G Deuschl, D Berg
Essential tremor (ET) is currently classified as a syndrome rather than a unique disease, primarily involving monosymptomatic action tremor in both hands. Different etiologies are presumed to underlie this condition. Currently only a few monogenetic conditions are known to present with this syndrome. If accompanied by additional symptoms that do not in themselves constitute a new syndrome, such as abnormal tandem gait or postures, the syndrome should be diagnosed as "ET plus". ET is associated with abnormal rhythmic activation of the cerebello-thalamo-cortical tremor circuit...
February 5, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29403215/in-vitro-cost-effective-methods-to-detect-carbapenemases-in-enterobacteriaceae
#18
Varsha Gupta, Ranu Soni, Neha Jain, Jagdish Chander
The rise in carbapenemases-producing organisms has challenged the scientific community. Infections caused by these bacteria have limited treatment options. There are various types such as Klebsiella pneumoniae carbapenemase (Ambler class A), metallo-beta-lactamases of VIM-type, IMP-type, NDM-type (Ambler class B), and OXA-48-types (Ambler class D). An efficient strategy for detection of carbapenemase producers is important to determine the appropriate therapeutic modalities. In this study, four methods - Carba NP test, modified Carba NP (MCNP) test, carbapenem inactivation method (CIM) test, and Rapidec Carba NP kit test were evaluated...
January 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29401610/an-image-based-small-molecule-screen-identifies-vimentin-as-a-pharmacologically-relevant-target-of-simvastatin-in-cancer-cells
#19
Kathryn P Trogden, Rachel A Battaglia, Parijat Kabiraj, Victoria J Madden, Harald Herrmann, Natasha T Snider
Vimentin is a cytoskeletal intermediate filament protein that is expressed in mesenchymal cells and cancer cells during the epithelial-mesenchymal transition. The goal of this study was to identify vimentin-targeting small molecules by using the Tocriscreen library of 1120 biochemically active compounds. We monitored vimentin filament reorganization and bundling in adrenal carcinoma SW13 vimentin-positive (SW13-vim+) cells via indirect immunofluorescence. The screen identified 18 pharmacologically diverse hits that included 2 statins-simvastatin and mevastatin...
January 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29396560/dynamic-changes-of-phenotypically-different-circulating-tumor-cells-sub-populations-in-patients-with-recurrent-refractory-small-cell-lung-cancer-treated-with-pazopanib
#20
Ippokratis Messaritakis, Eleni Politaki, Fillipos Koinis, Dimitris Stoltidis, Stella Apostolaki, Maria Plataki, Eleftheria-Kleio Dermitzaki, Vassilis Georgoulias, Athanasios Kotsakis
The aim of the study was to investigate the effect of 2nd-line pazopanib on the different CTCs subpopulations in SCLC patients and evaluate the clinical relevance of their changes. Different CTCs subpopulations were evaluated before pazopanib initiation (n = 56 patients), after one-cycle (n = 35) and on disease progression (n = 45) by CellSearch and double immunofluorescence using anti-CKs and anti-Ki67, anti-M30 or anti-Vimentin antibodies. Before treatment, CTCs were detected in 50% of patients by CellSearch whereas 53...
February 2, 2018: Scientific Reports
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