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https://www.readbyqxmd.com/read/29029114/carbapenem-resistant-citrobacter-spp-isolated-in-spain-from-2013-to-2015-produced-a-variety-of-carbapenemases-including-vim-1-oxa-48-kpc-2-ndm-1-and-vim-2
#1
David M Arana, Adriana Ortega, Eva González-Barberá, Noelia Lara, Verónica Bautista, Dolores Gómez-Ruíz, David Sáez, Sara Fernández-Romero, Belén Aracil, María Pérez-Vázquez, José Campos, Jesús Oteo
Objectives: There is little information about carbapenemase-producing (CP) Citrobacter spp. We studied the molecular epidemiology and microbiological features of CP Citrobacter spp. isolates collected in Spain (2013-15). Methods: In total, 119 isolates suspected of being CP by the EUCAST screening cut-off values were analysed. Carbapenemases and ESBLs were characterized using PCR and sequencing. The genetic relationship among Citrobacter freundii isolates was studied by PFGE...
September 27, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29027548/cu-2-complex-of-hydrophilic-nitrogen-rich-polymer-dots-applied-as-a-new-mri-contrast-agent
#2
Mengyue Hu, Jing Chen, Jingmin Wang, Ye Zhang, Li Liu, Paulo Cesar Morais, Hong Bi
We report on a novel Cu(2+)-complex of nitrogen-rich polymer dots for magnetic resonance imaging (MRI). The N-rich polymer dots are prepared from N-vinyl imidazole (VIm) by a one-pot hydrothermal synthesis at 220 °C (24 h) and used later on to fabricate a Cu(2+)-PVIm dot complex via efficient incorporation of Cu(2+) into aqueous medium. The obtained Cu(2+)-PVIm dot complexes display relaxivity (r1 = 1.05 mM(-1) s(-1)) two times higher than Cu(2+) in aqueous solution (r1 = 0.43 mM(-1) s(-1)) and three times higher than Cu(2+) in aqueous solution coordinated with VIm monomers (r1 = 0...
October 13, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29025287/-incidence-and-treatment-of-extranodal-natural-killer-t-cell-lymphoma-nasal-type-hungarian-experiences
#3
Annamária Bakos, Árpád Szomor, Tamás Schneider, Zsófia Miltényi, Imelda Marton, Zita Borbényi, Judit Pammer, László Krenács, Enikő Bagdi, Klára Piukovics
INTRODUCTION: Extranodal natural killer/T (NK/T) cell lymphoma, nasal type (ENKTL) represents a rare subtype of T-cell lymphomas with aggressive clinical behavior according to WHO 2016 classification. AIM: ENKTL has distinctive geographic distribution with higher incidence in Asia and Latin America (10% of all non-Hodgkin lymphoma cases), than in Europe and North America (<1%). ENKTL tipically origins from nasopharynx and upper aerodigestive tract. Anthracycline-based chemotherapy regimens are largely ineffective in the treatment of ENKTL...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29022193/development-of-a-modular-vapor-intrusion-model-with-variably-saturated-and-non-isothermal-vadose-zone
#4
Dawit N Bekele, Ravi Naidu, Sreenivasulu Chadalavada
Human health risk assessment at hydrocarbon-contaminated sites requires a critical evaluation of the exposure pathways of volatile organic compounds including assessments of vapor exposure in indoor air. Although there are a number of vapor intrusion models (VIM) currently available, they rarely reproduce actual properties of soils in the vadose zone. At best, users of such models assume averaged parameters for the vadose zone based on information generated elsewhere. The objective of this study was to develop a one-dimensional steady-state VIM, indoorCARE™ model, that considers vertical spatial variations of the degree of saturation (or effective air-filled porosity) and temperature of the vadose zone...
October 12, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28993328/molecular-characterization-of-carbapenemase-producing-pseudomonas-aeruginosa-of-czech-origin-evidence-for-clonal-spread-of-extensively-resistant-st357-expressing-imp-7-metallo-%C3%AE-lactamase
#5
Costas C Papagiannitsis, Matej Medvecky, Katerina Chudejova, Anna Skalova, Veronika Rotova, Petra Spanelova, Vladislav Jakubu, Helena Zemlickova, Jaroslav Hrabak
The objective of this study was to perform molecular surveillance for assessing the spread of carbapenemase-producing P. aeruginosa in Czech hospitals. One-hundred thirty-six carbapenemase-producing isolates were recovered from 22 hospitals, located throughout the country. ST357 dominated (n=120) among carbapenemase producers. One-hundred seventeen isolates produced IMP-type (IMP-7 [n=116] and IMP-1 [n=1]) metallo-β-lactamases (MβLs), fifteen produced the VIM-2 MβL, while the remaining isolates expressed the GES-5 enzyme...
October 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28981677/plasma-dna-methylation-marker-and-hepatocellular-carcinoma-risk-prediction-model-for-the-general-population
#6
Hui-Chen Wu, Hwai-I Yang, Qiao Wang, Chien-Jen Chen, Regina M Santella
Metastases in the later stages of hepatocellular carcinoma (HCC) cause the majority of deaths associated with the disease, making early detection crucial to patient survival. Risk models assessing HCC risk in the general population can be used for risk stratification for further HCC surveillance, however, none have been validated externally. Methylation of circulating DNA shows potential for non-invasive diagnosis of HCC. We conducted a prospective case-control study nested within a community-based cohort. We measured methylation levels in six genes (CDKN2A, RASSF1A, STEAP4, TBX2, VIM and ZNF154) which were identified in our previous work, using pre-diagnostic plasma DNA from 237 HCC cases and 257 matched controls...
August 3, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28980000/increased-indoleamine-2-3-dioxygenase-and-quinolinic-acid-expression-in-microglia-and-m%C3%A3-ller-cells-of-diabetic-human-and-rodent-retina
#7
Ping Hu, Nicholas H Hunt, Frank Arfuso, Lynn C Shaw, Mohammad Nasir Uddin, Meidong Zhu, Raj Devasahayam, Samuel J Adamson, Vicky L Benson, Tailoi Chan-Ling, Maria B Grant
Purpose: We investigated the relationship between inflammation, neuronal loss, and expression of indoleamine 2, 3-dioxygenase (IDO) and quinolinic acid (QUIN) in the retina of subjects with type 1 diabetes (T1D) and type 2 diabetes (T2D) and in the retina of rats with T1D. Methods: Retinas from T1D (n = 7), T2D (n = 13), and 20 age-matched nondiabetic human donors and from T1D (n = 3) and control rats (n = 3) were examined using immunohistochemistry for IDO, QUIN, cluster of differentiation 39 (CD39), ionized calcium-binding adaptor molecule (Iba-1, for macrophages and microglia), Vimentin (VIM; for Müller cells), neuronal nuclei (NeuN; for neurons), and UEA1 lectin (for blood vessels)...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28978681/high-stringency-evaluation-of-the-automated-bd-phoenix%C3%A2-cpo-detect-and-rapidec%C3%A2-carba-np-tests-for-detection-and-classification-of-carbapenemases
#8
Gina Thomson, David Turner, William Brasso, Susan Kircher, Thierry Guillet, Kenneth Thomson
There is an urgent need for rapid, accurate detection and classification of carbapenemases. The current study evaluated the automated BD Phoenix™ CPO Detect and the manual bioMérieux RAPIDEC® CARBA NP for meeting these needs. Both tests were challenged with 294 Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii chosen to provide extreme diagnostic difficulty. Carbapenemases such as KPC, NMC-A, IMI, SME, NDM, SPM, IMP, VIM, OXA-23, 40, 48, 58, 72, 181, and 232 were produced by 243 isolates and 51 carbapenemase-negative isolates included porin mutants and producers of ESBLs, AmpCs, K1, and broad spectrum β-lactamases...
October 4, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28971872/kinetics-of-sulbactam-hydrolysis-by-%C3%AE-lactamases-and-their-inhibition
#9
Adam B Shapiro
Sulbactam is one of 4 β-lactamase inhibitors in current clinical use to counteract drug resistance caused by degradation of β-lactam antibiotics by these bacterial enzymes. As a β-lactam itself, sulbactam is susceptible to degradation by β-lactamases. We investigated the Michaelis-Menten kinetics of sulbactam hydrolysis by 14 β-lactamases representing clinically widespread groups within all 4 Ambler classes: CTX-M-15, KPC-2, SHV-5, and TEM-1 for class A; IMP-1, NDM-1, and VIM-1 for class B; Acinetobacter baumannii ADC-7, Pseudomonas aeruginosa AmpC and Enterobacter cloacae P99 for class C; and OXA-10, OXA-23, OXA-24, and OXA-48 for class D...
October 2, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28961968/susceptibility-of-mdr-pseudomonas-aeruginosa-to-ceftolozane-tazobactam-and-comparison-of-different-susceptibility-testing-methods
#10
Frieder Schaumburg, Stefan Bletz, Alexander Mellmann, Karsten Becker, Evgeny A Idelevich
Background: Infections caused by MDR Pseudomonas aeruginosa are on the rise, particularly in critically ill patients. Therefore, there is a need to evaluate new antimicrobial regimens. The objectives of this study were to investigate the ceftolozane/tazobactam resistance rates of MDR and XDR P. aeruginosa , the underlying resistance genes, the clonal structure and different antimicrobial susceptibility testing (AST) methods regarding their accuracy for ceftolozane/tazobactam testing. Methods: In total, 112 MDR and XDR P...
August 11, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28956310/increased-neuronal-differentiation-of-neural-progenitor-cells-derived-from-phosphovimentin-deficient-mice
#11
Meng Chen, Till B Puschmann, Pavel Marasek, Masaki Inagaki, Marcela Pekna, Ulrika Wilhelmsson, Milos Pekny
Vimentin is an intermediate filament (also known as nanofilament) protein expressed in several cell types of the central nervous system, including astrocytes and neural stem/progenitor cells. Mutation of the vimentin serine sites that are phosphorylated during mitosis (VIM (SA/SA) ) leads to cytokinetic failures in fibroblasts and lens epithelial cells, resulting in chromosomal instability and increased expression of cell senescence markers. In this study, we investigated morphology, proliferative capacity, and motility of VIM (SA/SA) astrocytes, and their effect on the differentiation of neural stem/progenitor cells...
September 27, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28950869/phylogenetic-assessment-reveals-continuous-evolution-and-circulation-of-pigeon-derived-virulent-avian-avulaviruses-1-in-eastern-europe-asia-and-africa
#12
Mahmoud Sabra, Kiril M Dimitrov, Iryna V Goraichuk, Abdul Wajid, Poonam Sharma, Dawn Williams-Coplin, Asma Basharat, Shafqat F Rehmani, Denys V Muzyka, Patti J Miller, Claudio L Afonso
BACKGROUND: The remarkable diversity and mobility of Newcastle disease viruses (NDV) includes virulent viruses of genotype VI. These viruses are often referred to as pigeon paramyxoviruses 1 because they are normally isolated and cause clinical disease in birds from the Columbidae family. Genotype VI viruses occasionally infect, and may also cause clinical disease in poultry. Thus, the evolution, current spread and detection of these viruses are relevant to avian health. RESULTS: Here, we describe the isolation and genomic characterization of six Egyptian (2015), four Pakistani (2015), and two Ukrainian (2007, 2013) recent pigeon-derived NDV isolates of sub-genotype VIg...
September 26, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28947532/epithelial-vimentin-plays-a-functional-role-in-mammary-gland-development
#13
Emilia Peuhu, Reetta Virtakoivu, Anja Mai, Anni Wärri, Johanna Ivaska
In the mammary gland, vimentin intermediate filaments are expressed in stromal cells and in basal epithelial cell populations including gland-reconstituting mammary stem cells, with largely undefined functions. Here, we studied how vimentin deficiency affects mouse mammary gland development. We find that in adult vimentin knockout mice (Vim-/-) mammary ductal outgrowth is delayed. The adult Vim-/- glands display dilated ducts and reduced basal to luminal mouse mammary epithelial cell (MMEC) ratio indicative of altered progenitor cell activity...
September 25, 2017: Development
https://www.readbyqxmd.com/read/28946568/protein-expression-profiling-in-the-hippocampus-after-focal-cerebral-ischemia-injury-in-rats
#14
Lichan He, Rui He, Ruihua Liang, Yi Li, Xiaoqiang Li, Chuqiao Li, Suping Zhang
In this study, we aimed to explore protein expression profiles in the hippocampus of rats after the induction of focal ischemia injury. Forty SD male rats were randomly divided into 4 groups, with ten rats per group: the control, Day 3, Day 7, and Day 14 after the ischemia injury surgery. Focal cortical ischemia was induced in thirty rats by photothrombosis of the cortical microvessels. After surgery, the induction of ischemia was confirmed by the measurement of infarct size using 2,3,5-triphenyltetrazolium chloride (TTC) staining...
September 20, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/28946009/selection-of-reference-genes-for-quantitative-real-time-pcr-analysis-in-chicken-ovary-following-silver-nanoparticle-treatment
#15
Dorota Katarzyńska-Banasik, Małgorzata Grzesiak, Andrzej Sechman
Reliable results of quantitative real time PCR (qPCR) analysis require normalization of target gene expression level using reference genes (RGs). However housekeeping genes expression may vary under experimental conditions, so selection of the proper RGs is a crucial step in a qPCR analysis. Several algorithms have been developed to address this problem: geNorm, NormFinder and BestKeeper. In this study, we have used these three tools to evaluate the stability of RGs in the ovarian tissues of hens treated with silver nanoparticles...
September 20, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28942466/assessing-the-clinical-outcome-of-vim-radiosurgery-with-voxel-based-morphometry-visual-areas-are-linked-with-tremor-arrest
#16
Constantin Tuleasca, Tatiana Witjas, Elena Najdenovska, Antoine Verger, Nadine Girard, Jerome Champoudry, Jean-Philippe Thiran, Dimitri Van de Ville, Meritxell Bach Cuadra, Marc Levivier, Eric Guedj, Jean Régis
INTRODUCTION: Radiosurgery (RS) is an alternative to open standard stereotactic procedures (deep-brain stimulation or radiofrequency thalamotomy) for drug-resistant essential tremor (ET), aiming at the same target (ventro-intermediate nucleus, Vim). We investigated the Vim RS outcome using voxel-based morphometry by evaluating the interaction between clinical response and time. METHODS: Thirty-eight patients with right-sided ET benefited from left unilateral Vim RS...
September 23, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28912461/vimentin-knockout-results-in-increased-expression-of-sub-endothelial-basement-membrane-components-and-carotid-stiffness-in-mice
#17
Benoit Langlois, Ekaterina Belozertseva, Ara Parlakian, Mustapha Bourhim, Jacqueline Gao-Li, Jocelyne Blanc, Lei Tian, Dario Coletti, Carlos Labat, Zhor Ramdame-Cherif, Pascal Challande, Véronique Regnault, Patrick Lacolley, Li Zhenlin
Intermediate filaments are involved in stress-related cell mechanical properties and in plasticity via the regulation of focal adhesions (FAs) and the actomyosin network. We investigated whether vimentin regulates endothelial cells (ECs) and vascular smooth muscle cells (SMCs) and thereby influences vasomotor tone and arterial stiffness. Vimentin knockout mice (Vim(-/-)) exhibited increased expression of laminin, fibronectin, perlecan, collagen IV and VE-cadherin as well as von Willebrand factor deposition in the subendothelial basement membrane...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28902598/correction-to-viral-immunol-2017-30-298-301-doi-10-1089-vim-2016-0152
#18
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Viral Immunology
https://www.readbyqxmd.com/read/28900381/the-association-of-vimentin-and-fibronectin-gene-expression-with-epithelial-mesenchymal-transition-and-tumor-malignancy-in-colorectal-carcinoma
#19
Zohreh Niknami, Ali Eslamifar, Amirnader Emamirazavi, Alireza Ebrahimi, Reza Shirkoohi
Colorectal cancer is the most common malignancy of the gastrointestinal tract with very high mortality. One of the most distinguishing features for the establishment of an epithelial-mesenchymal transition phenotype is the alteration of mesenchymal markers expression and structural adhesion proteins. We evaluated the significance of vimentin and fibronectin gene expression in relation to invasion and metastasis in CRC patients. Tissue specimens were collected consecutively from forty-five colorectal carcinoma patients during surgeries...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28889124/factors-affecting-stereotactic-accuracy-in-image-guided-deep-brain-stimulator-electrode-placement
#20
Andrew L Ko, Aly Ibrahim, Philippe Magown, Rebecca Macallum, Kim J Burchiel
BACKGROUND/AIMS: Intraoperative imaging allows near-real-time assessment of stereotactic accuracy during implantation of deep brain stimulation (DBS) electrodes. Such technology can be used to examine factors impacting stereotactic error. METHODS: Intraoperative CT imaging was reviewed in patients undergoing DBS placement at Oregon Health and Sciences University. Coordinates of the target electrode were compared to the operative plan to characterize the magnitude and direction of stereotactic error with respect to side of implantation, target, and electrode approach angles...
September 9, 2017: Stereotactic and Functional Neurosurgery
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