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Matthew A Borgman, Morten Zaar, James K Aden, Zachary J Schlader, Daniel Gagnon, Eric Rivas, Jena Kern, Victor A Convertino, Andrew P Cap, Craig G Crandall
Heat stress followed by an accompanying hemorrhagic challenge may influence hemostasis. We tested the hypothesis that hemostatic responses are increased by passive heat stress, and exercise-induced heat stress, each with accompanying central hypovolemia to simulate a hemorrhagic insult. In Aim 1, subjects were exposed to passive heating or normothermic time control, each followed by progressive lower-body negative pressure (LBNP) to pre-syncope. In Aim 2 subjects exercised in hyperthermic environmental conditions, with and without accompanying dehydration, each also followed by progressive LBNP to pre-syncope...
September 19, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
V López-López, P B Lynn, J Gil, M García-Salom, E Gil, A González, I P Muñoz, P A Cascales-Campos
BACKGROUND: Paclitaxel has been used frequently for Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for ovarian carcinomatosis. Cytoreductive surgery and HIPEC are associated with high rates of morbidity being anastomotic dehiscence one of the most frequent. The objective of this study is to quantify the effect of Paclitaxel-based HIPEC on colonic anastomosis in an experimental rat model. METHODS: After left colon resection and anastomosis, animals were randomized into four groups: Controls (C); Hyperthermia (H); Normothermic Intraperitoneal Paclitaxel (CP) and Paclitaxel-based HIPEC (HP)...
September 18, 2018: Clinical & Translational Oncology
Sungmin Lee, Beomseok Son, Gaeul Park, Hyunwoo Kim, Hyunkoo Kang, Jaewan Jeon, HyeSook Youn, BuHyun Youn
Hyperthermia is a cancer treatment where tumor tissue is heated to around 40 °C. Hyperthermia shows both cancer cell cytotoxicity and immune response stimulation via immune cell activation. Immunogenic responses encompass the innate and adaptive immune systems, involving the activation of macrophages, natural killer cells, dendritic cells, and T cells. Moreover, hyperthermia is commonly used in combination with different treatment modalities, such as radiotherapy and chemotherapy, for better clinical outcomes...
September 17, 2018: International Journal of Molecular Sciences
Helena C Besse, Clemens Bos, Maurice M J M Zandvliet, Kim van der Wurff-Jacobs, Chrit T W Moonen, Roel Deckers
INTRODUCTION: To increase the efficacy of chemoradiation and decrease its toxicity in normal tissue, a new concept is proposed, local radiosensitizer delivery, which combines triggered release of a radiosensitizer from thermosensitive liposomes with local hyperthermia and radiotherapy. Here, key aspects of this concept were investigated in vitro I) the effect of hyperthermia on the enhancement of radiotherapy by ThermoDox (thermosensitive liposome containing doxorubicin), II) the concentration dependence of the radiosensitizing effect of doxorubicin and III) the sequence of doxorubicin, hyperthermia and radiotherapy maximizing the radiosensitizing effect...
2018: PloS One
Maria B C de Matos, Nataliia Beztsinna, Christoph Heyder, Marcel H A M Fens, Enrico Mastrobattista, Raymond M Schiffelers, Gero Leneweit, Robbert J Kok
Lysolipid-containing thermosensitive liposomes (LTSL) are clinically-relevant drug nanocarriers which have been used to deliver small molecule cytostatics to tumors in combination with local hyperthermia (42 °C) to trigger local drug release. The objective of this study was to investigate the feasibility of LTSL for encapsulation and triggered release of macromolecular drugs such as plant-derived cytotoxins. As therapeutic protein we used Mistletoe lectin-1 (ML1) - a ribosome-inactivating protein with potent cytotoxic activity in tumor cells...
September 14, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Amra Sakusic, Ognjen Gajic, Tarun D Singh, John C O'Horo, Gregory Jenkins, Gregory A Wilson, Ronald Petersen, John D Fryer, Rahul Kashyap, Alejandro A Rabinstein
OBJECTIVES: Persistent cognitive impairment after critical illness is an important healthcare problem forecasted to worsen in the near future. However, the epidemiology is insufficiently explored. We aimed to determine potentially modifiable risk factors during ICU hospitalization that play a significant role in developing persistent cognitive impairment. DESIGN: An observational case-control study. SETTINGS: Mayo Clinic ICUs between July 1, 2004, and November 20, 2015...
September 14, 2018: Critical Care Medicine
Ken Ando, Yoshiyuki Suzuki, Takuya Kaminuma, Yuya Yoshimoto, Takahiro Oike, Noriyuki Okonogi, Hiro Sato, Tomoaki Tamaki, Shin-Ei Noda, Kosaku Mimura, Takashi Nakano
PURPOSE: This study aimed to elucidate the contribution of T cell-mediated antitumor immunity in the antitumor effect of local hyperthermia (LH). MATERIALS AND METHODS: C57BL/6J mice were injected with the mouse lymphoma cell line, E.G7-OVA, in the right femur on day 0. LH was induced by immersing the right femur in a water bath at 42 °C for 60 min on day 7, followed by administration of anti-CD8 monoclonal antibodies (mAb) or anti-CTLA-4 mAb (days 8, 11, and 14)...
September 17, 2018: International Journal of Hyperthermia
Ann E Klega, Jennifer Tickal Keehbauch
Approximately 10% of the U.S. population 12 years and older reported using illicit substances in 2015. This article reviews the clinical effects and treatment of persons who use cocaine, methamphetamines, 3,4-methylenedioxymethamphetamine (MDMA), synthetic cannabinoids, and synthetic cathinones ("bath salts"). Cocaine blocks the reuptake of the monoamine transporters dopamine, norepinephrine, and serotonin. Immediate clinical effects include increased energy and euphoria, as well as hypertension and arrhythmias...
July 15, 2018: American Family Physician
Luo Gang, Kyoko Oka, Shirabe Ohki, Mihoko Rikitake, Satoshi Itaya, Shougo Tamura, Masako Toda-Nakamura, Kayoko Ogata, Michiko Kira-Tatsuoka, Masao Ozaki
The treatment of ulceration or stomatitis with laser therapy is known to accelerate healing and relieve pain, but the underlying biological mechanism is not fully understood. The present study used a mouse model of ulceration to investigate the molecular mechanisms by which CO₂ laser therapy accelerated the wound healing process. An ulcer was experimentally created in the palatal mucosa of the mouse and irradiated with light from a CO₂ laser. Compared with controls (no irradiation), laser irradiation induced the proliferation of epithelial cells and faster re-epithelialization of the wound area...
June 1, 2018: Histology and Histopathology
Xiao Xu, Yildiz Bayazitoglu, Andrew Meade
Using gold-silica nanoshell as a reference nano-agent, this work has performed preliminary numerical parametric study to investigate the feasibility and if feasible the efficiency of using a single nano-agent to achieve theranostic goals. In total, seven generics of gold-silica nanoshells have been tested including the R[50,10] (radius of the silica core is 50 nm and thickness of the gold shell is 10 nm), R[40,15], R[55,25], R[40,40], R[75,40], R[104,23], and R[154,24] nanoshells. A planar tissue model has been constructed as the platform for parametric study...
September 13, 2018: Lasers in Medical Science
Xiaoxia Han, Xiangxiang Jing, Dayan Yang, Han Lin, Zhigang Wang, Haitao Ran, Pan Li, Yu Chen
Two-dimensional (2D) MXenes have emerged as a promising planar theranostic nanoplatform for versatile biomedical applications; but their in vivo behavior and performance has been severely influenced and hindered by a lack of necessary surface chemistry for adequate surface engineering. To solve this critical issue, this work employs versatile sol-gel chemistry for the construction of a unique "therapeutic mesopore" layer onto the surface of 2D niobium carbide (Nb2 C) MXene. Methods: The in situ self-assembled mesopore-making agent (cetanecyltrimethylammonium chloride, in this case) was kept within the mesopores for efficient chemotherapy...
2018: Theranostics
Brian M Zanghi, Patrick J Robbins, Meghan T Ramos, Cynthia M Otto
Exercise-related physiological changes were evaluated in hydrated, exercise-conditioned working dogs with free access to tap water (TW) with or without a nutrient-enriched water supplement (NW). Physiological samples and measures were collected before and after work-related field tasks in a warm and moderately humid ambient environment. In a cross-over design study, 12 dogs (age range 8-23 months) were evaluated on 3 separate occasions within each period with exercise bouts up to 30 min, on days -4, 3, and 11...
2018: Frontiers in Veterinary Science
Jingfeng Luo, Jiali Zhou, Fengnan Xie, Yali Zhu, Fei Zhou, Shuanglin Zhang, Shaojie Jiang, Jie He, Jiaxin Liu, Xia Wu, Yanhua Zhang, Jihong Sun, Xiaoming Yang
Cholangiocarcinoma is a most lethal malignancy frequently resistant to chemotherapy. Herpes simplex virus thymidine kinase/Ganciclovir (HSV-TK/GCV) suicide gene therapy is a promising approach to treat different cancers, including cholangiocarcinoma. However drawbacks including low therapeutic gene expression and lack of precise targeted gene delivery limit the wide clinical utilization of the suicide gene therapy. We attempted to overcome these obstacles. We established the "proof-of-principle" of this concept via serial in-vitro experiments using human cholangiocarcinoma cells and then validated the new interventional oncology technique in vivo using mice harboring the same patient derived cholangiocarcinomas...
2018: American Journal of Cancer Research
Falian Zhu, Guozhu Tan, Yaodong Jiang, Zhiqiang Yu, Fei Ren
In recent decades, the development of novel photorelated nanomedicines as precise cancer nanotheranostics has received extensive attention. However, strategies aimed at integrating various stimuli-responsive multimodal therapies are needed. Herein, we developed a novel system for combined plasmonic photothermal therapy (PPTT) and chemotherapy using the tumor microenvironment and near-infrared (NIR)-responsive gold nanorod-drug conjugates (Au NR@Curcumin). To synthesize this conjugate, the alkanethiol aliphatic acid (11-mercaptoundecanoic acid, MUA) group was covalently linked to curcumin via an ester bond...
September 13, 2018: Biomaterials Science
Mami Nakamura, Kaori Shintani-Ishida, Hiroshi Ikegaya
Recreational drugs, such as 3,4-methylenedioxymethamphetamine (MDMA) and cocaine, induce hyperthermia, which is affected by ambient temperature. 2-(4-Bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25B-NBOMe), a selective agonist of 5-HT2A receptor used as a recreational drug, reportedly induces hyperthermia. This study aimed to verify whether 25B-NBOMe induces ambient temperature-dependent hyperthermia and to clarify its mechanism. Eight-week-old male Sprague-Dawley rats were administered intraperitoneal injection of 25B-NBOMe at an ambient temperature of 23°C or 29°C...
September 11, 2018: Journal of Pharmacology and Experimental Therapeutics
Yu L Vasil'ev, S A Rabinovich, S S Dydykin, V A Logachev, U A Pikhlak
It is known that the reduction of blood vessels by epinephrine that are part of the local anesthetic leads to a decrease in oxygen intake and the development of hypoxia, which has a significant effect on the excitability of nerve fibers. This is due to the fact that epinephrine is present in the local anesthetic cartridge, which helps to reduce, until termination, microcirculation in the depot area, which leads to local hypothermia. With the introduction of local anesthetics, the temperature of which is significantly lower than the depot temperature, the patient experiences severe discomfort, which is associated with unsuccessful local anesthesia...
2018: Stomatologii︠a︡
Franchi Angélique, Gauchotte Guillaume, Gambier Nicolas, Raul Jean Sébastien, Martrille Laurent
In this daily practice, the forensic pathologist is rarely confronted with postmortem hyperthermia associated with the rapid onset of rigor mortis. We report 2 similar cases where the rectal temperature value taken during the on-scene investigations by the forensic pathologist was greater than 40°C (104°F) in both cases, and rigor mortis was complete within less than 6 hours postmortem. The first case was due to a deadly intoxication by ecstasy and the second one to the deadly association of methadone and a possible neuroleptic malignant syndrome...
September 6, 2018: American Journal of Forensic Medicine and Pathology
Angelie Rivera-Rodriguez, Andreina Chiu-Lam, Viacheslav M Morozov, Alexander M Ishov, Carlos Rinaldi
Introduction: Overcoming resistance to antimitotic drugs, such as paclitaxel (PTX), would represent a major advance in breast cancer treatment. PTX induces mitotic block and sensitive cells exit mitosis dying by mitotic catastrophe. Resistant cells remain in block and continue proliferation after drug decay, denoting one of the PTX resistance mechanisms. Mild hyperthermia (HT) triggers mitotic exit of PTX-pretreated cells, overcoming PTX resistance and suggesting HT-forced mitotic exit as a promising strategy to potentiate PTX...
2018: International Journal of Nanomedicine
I Khmelinskii, V I Makarov
Presently we communicate a newly developed method of resonant radiofrequency heating, applicable in hyperthermal therapy. This method uses electron paramagnetic resonance (EPR) to transform the electromagnetic field energy into heat. We report the growth dynamics of the S. cerevisiae yeast cells exposed to EPR heating with superparamagnetic magnetite (Fe3 O4 ) nanoparticles, with only 4% of yeast cells surviving hyperthermia. Given that EPR functions independently of type of the biologic species exposed, and produces spatially localized heating in conjunction with MRI hardware, it may be used in hyperthermal therapy of cancer and other diseases...
October 2018: Journal of Thermal Biology
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