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Zhaoxu Tu, Haishi Qiao, Yuting Yan, Guy Guday, Wei Chen, Mohsen Adeli, Rainer Haag
Multidrug resistance (MDR), which leads tumors resistance to traditional anticancer drugs, can cause the failure of chemotherapy treatments. In this work, we present a new way to overcome this problem using smart multifunctional graphene-based drug delivery systems which can target subcellular organelles and show synergistic hyperthermia and chemotherapy. Mitochondria-targeting ligands are conjugated onto the doxorubicin-loaded, polyglycerol-covered nanographene sheets to actively accumulate them inside the mitochondria after charge-mediated cellular internalization...
June 15, 2018: Angewandte Chemie
J Uerlings, Z G Song, X Y Hu, S K Wang, H Lin, Johan Buyse, N Everaert
Dysfunction of the intestinal epithelial barrier under elevated temperatures is assumed to prompt pathological conditions and to eventually impede chickens' growth, resulting in massive economic losses in broiler industries. The aims of this research were to determine the impact of acute heat stress on the intestinal tight junction network of broiler chicks (Gallus domesticus L.) and to elucidate whether adenosine monophosphate-activated protein kinase (AMPK) was involved in the integrated response of the broiler's gastrointestinal tract to heat stress...
June 13, 2018: Poultry Science
Christian K Garcia, Alex J Mattingly, Gerard P Robinson, Orlando Laitano, Michelle A King, Shauna M Dineen, Lisa R Leon, Thomas L Clanton
With increasing participation of females in endurance athletics and active military service, it is important to determine if there are inherent sex-dependent susceptibilities to exertional heat injury or heat stroke. In this study we compared responses of male and female adult mice to exertional heat stroke (EHS). All mice were instrumented for telemetry core temperature measurement and were exercise-trained for 3 weeks prior to EHS. During EHS, environmental temperature was 37.5{degree sign}C (35% RH) while the mice ran on a forced running wheel, using incremental increases in speed...
June 14, 2018: Journal of Applied Physiology
Yan-Yan Zhao, Qiong Wu, Zhi-Bing Wu, Jing-Jing Zhang, Lu-Cheng Zhu, Yang Yang, Sheng-Lin Ma, Shi-Rong Zhang
Post-operative microwave (MW) hyperthermia has been applied as an important adjuvant therapy to enhance the efficacy of traditional cancer treatment. A better understanding of the molecular mechanisms of MW hyperthermia may provide guided and further information on clinical hyperthermia treatment. In this study, we examined the effects of MW hyperthermia on non‑small cell lung carcinoma (NSCLC) cells in vitro, as well as the underlying mechanisms. In order to mimic clinical treatment, we developed special MW heating equipment for this study...
June 13, 2018: International Journal of Oncology
Magdalena Osial, Paulina Rybicka, Marek Pękała, Grzegorz Cichowicz, Michał K Cyrański, Paweł Krysiński
The exceptional magnetic properties of superparamagnetic iron oxide nanoparticles (SPIONs) make them promising materials for biomedical applications like hyperthermia, drug targeting and imaging. Easy preparation of SPIONs with the controllable, well-defined properties is a key factor of their practical application. In this work, we report a simple synthesis of Ho-doped SPIONs by the co-precipitation route, with controlled size, shape and magnetic properties. To investigate the influence of the ions ratio on the nanoparticles’ properties, multiple techniques were used...
June 13, 2018: Nanomaterials
Wei Li, Wanqing Hou, Xiaomeng Guo, Lihua Luo, Qingpo Li, Chunqi Zhu, Jie Yang, Jiang Zhu, Yongzhong Du, Jian You
Recently, nano-sized ultrasound contrast agents encapsulating drugs for cancer diagnosis and therapy have attracted much attention. However, the ultrasound signal of these agents is too weak to obtain an ideal ultrasound imaging effect. Furthermore, conventional ultrasound contrast agents with strong echo signal are not suitable for drug delivery against cancer because of their large size. To circumvent this problem, phase-transition ultrasound contrast agents are believed to be an excellent choice. Methods: Liposomes co-encapsulating doxorubicin (DOX), hollow gold nanospheres (HAuNS), and perfluorocarbon (PFC) were synthesized by film dispersion method...
2018: Theranostics
Kristina A Muise, Allyson K Menzies, Craig K R Willis
Acute stressors such as capture and handling can elicit physiological responses in endothermic animals. One example of such a response is an increase in body temperature (Tb ) commonly referred to as stress-induced hyperthermia (SIH). For species that employ torpor, typically an inactive state characterized by a controlled reduction in Tb and metabolic rate, a rapid increase in Tb could be advantageous, especially in the context of escape from predators. We quantified SIH in silver-haired bats (Lasionycteris noctivagans) because they readily enter torpor and often roost in exposed places where they could be vulnerable to predators...
June 9, 2018: Physiology & Behavior
Xu-Hua Duan, Hao Li, Xin-Wei Han, Jian-Zhuang Ren, Feng-Yao Li, Shu-Guang Ju, Peng-Fei Chen, Dong-Lin Kuang
Increasing evidences suggested that insufficient radiofrequency ablation (RFA) can paradoxically promote tumor invasion and metastatic processes, while the effects of moderate hyperthermia on cancer progression are not well illustrated. Our present study confirmed moderate hyperthermia treatment can promote the proliferation, migration and invasion of hepatocellular carcinoma (HCC) cells, which was evidenced by the results that moderate hyperthermia induced up regulation of proliferating cell nuclear antigen (PCNA) and matrix metalloproteinase-2 (MMP-2)...
June 9, 2018: European Journal of Pharmacology
Yu Han, Zhongping Chen, Hong Zhao, Zengshi Zha, Wendong Ke, Yuheng Wang, Zhishen Ge
Tumor hypoxia strikingly restricts photodynamic therapy (PDT) efficacy and limits its clinical applications in cancer therapy. The ideal strategy to address this issue is to develop oxygen-independent PDT systems. Herein, the rationally designed tumor pH-responsive polymeric micelles are devised to realize oxygen-independent combined PDT and photothermal therapy (PTT) under near-infrared light (NIR) irradiation. The triblock copolymer, poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(2-(piperidin-1-yl)ethyl methacrylate) (PEG-b-PCL-b- PPEMA), was prepared to co-encapsulate cypate and singlet oxygen donor (diphenylanthracene endoperoxide, DPAE) via self-assembly to obtain the micellar delivery system (C/O@N-Micelle)...
June 9, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Natália Babincová, Paul Sourivong, Peter Babinec, Christian Bergemann, Melánia Babincová, Štefan Durdík
There is substantial evidence regarding enhanced antitumor cytotoxicity of selected chemotherapeutic agents by appropriate heat exposure (40-44°C). Based upon these results, the integration of hyperthermia as an additional treatment modality given simultaneously with systemic chemotherapy is currently of considerable interest. Hyperthermia can be induced by alternating magnetic field and magnetic nanoparticles. Thus, we have used thermosensitive magnetoliposomes that contained superparamagnetic iron oxide nanoparticles and doxorubicin for in vitro and in vivo therapy of rat glioma C6...
June 12, 2018: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Jiansong Ji, Qiaoyou Weng, Feng Zhang, Fu Xiong, Yin Jin, Junguo Hui, Jingjing Song, Jun Gao, Minjiang Chen, Qiang Li, David Shin, Xiaoming Yang
Purpose To validate the feasibility and efficacy of intratumoral radiofrequency hyperthermia (RFH)-enhanced herpes simplex virus (HSV) thymidine kinase (TK) and ganciclovir (GCV) (hereafter, HSV-TK/GCV) gene therapy for non-small-cell lung cancer (NSCLC). Materials and Methods This study was performed from November 11, 2015, to April 14, 2017, and included (a) in vitro experiments with human NSCLC cells to establish the proof of principle, (b) in vivo experiments using mice with subcutaneous NSCLC to further demonstrate the principle, and (c) in vivo experiments using rats with orthotopic NSCLC to validate the technical feasibility...
June 12, 2018: Radiology
Giacomo Dacarro, Angelo Taglietti, Piersandro Pallavicini
Prussian blue (PB) is a coordination polymer studied since the early 18th century, historically known as a pigment. PB can be prepared in colloidal form with a straightforward synthesis. It has a strong charge-transfer absorption centered at ~700 nm, with a large tail in the Near-IR range. Irradiation of this band results in thermal relaxation and can be exploited to generate a local hyperthermia by irradiating in the so-called bio-transparent Near-IR window. PB nanoparticles are fully biocompatible (PB has already been approved by FDA) and biodegradable, this making them ideal candidates for in vivo use...
June 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Laís Salomão Arias, Juliano Pelim Pessan, Ana Paula Miranda Vieira, Taynara Maria Toito de Lima, Alberto Carlos Botazzo Delbem, Douglas Roberto Monteiro
Medical applications and biotechnological advances, including magnetic resonance imaging, cell separation and detection, tissue repair, magnetic hyperthermia and drug delivery, have strongly benefited from employing iron oxide nanoparticles (IONPs) due to their remarkable properties, such as superparamagnetism, size and possibility of receiving a biocompatible coating. Ongoing research efforts focus on reducing drug concentration, toxicity, and other side effects, while increasing efficacy of IONPs-based treatments...
June 9, 2018: Antibiotics
Zhen Shi, Bin Lan, Baowei Peng, Xuefeng Wang, Ganggang Zhang, Xiaohu Li, Fang Guo
Malignant melanoma has shown increased incidence and high mortality rate in the last three decades. In this study, we investigated whether combination therapy with ch282-5 (a novel BH3 mimetic) and microwave hyperthermia could display synergistic antitumor effects against melanoma. Our results indicated that combination therapy reduced the viability and proliferation of melanoma cells. Through inhibiting the expression of anti-apoptotic proteins of Bcl-2 and IAP family and activating MAPK proteins, combined hyperthermia enhanced ch282-5-induced apoptosis...
June 7, 2018: Biochemical and Biophysical Research Communications
Mu Li, Xiangmei Liu, Lei Tan, Zhenduo Cui, Xianjin Yang, Zhaoyang Li, Yufeng Zheng, Kelvin Wai Kwok Yeung, Paul K Chu, Shuilin Wu
Bacterial infection often delays healing of wounded tissues and so it is essential to improve the antibacterial efficiency in situ. In this work, a hybrid hydrogel composed of 3-(trimethoxysilyl)propyl methacrylate (MPS, 97%) and mesoporous silica (mSiO2) modified CuS nanoparticles (NPs) is synthesized by radical polymerization. The materials possess excellent and controllable photothermal and photodynamic properties under 808 nm near-infrared (NIR) light irradiation as well as an antibacterial efficacy of 99...
June 8, 2018: Biomaterials Science
J P Kastelic, G Rizzoto, J Thundathil
Several structural and functional features keep bull testes 2°C to 6°C below body temperature, essential for the production of morphologically normal, motile and fertile sperm. The testicular vascular cone (TVC), located above the testis, consists of a highly coiled testicular artery surrounded by a complex network of small veins (pampiniform plexus). The TVC functions as a counter-current heat exchanger to transfer heat from the testicular artery to the testicular vein, cooling blood before it enters the testis...
June 2018: Animal: An International Journal of Animal Bioscience
Franziska Eckert, Daniel Zips
No abstract text is available yet for this article.
June 7, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
N V Srikanth Vallabani, Sanjay Singh
Superparamagnetic iron oxide nanoparticles (SPIONs) are considered as chemically inert materials and, therefore, being extensively applied in the areas of imaging, targeting, drug delivery and biosensors. Their unique properties such as low toxicity, biocompatibility, potent magnetic and catalytic behavior and superior role in multifunctional modalities have epitomized them as an appropriate candidate for biomedical applications. Recent developments in the area of materials science have enabled the facile synthesis of Iron oxide nanoparticles (IONPs) offering easy tuning of surface properties and surface functionalization with desired biomolecules...
June 2018: 3 Biotech
Jennifer L Smith, Meaghan A Tranovich, Nabil A Ebraheim
Most frequently associated with orthopedic surgery, malignant hyperthermia is a rare genetic condition linked to volatile anesthetics and succinylcholine. If not treated quickly with appropriate measures, death may result. To aid in the prevention of further fatalities, this review seeks to educate clinicians and staff on the presentation and treatment of this disease, as well as to provide a comprehensive overview by further addressing prevalence, similar conditions, pathogenesis and other aspects. Although the number of deaths due to malignant hyperthermia has greatly declined in the last several years, increased knowledge may eliminate associated mortalities, particularly in the orthopedic setting...
June 2018: Journal of Orthopaedics
Joe S Smith, Jonathan P Mochel, David J Borts, Kerrie A Lewis, Johann F Coetzee
OBJECTIVE: To describe adverse reactions and measure plasma fentanyl concentrations in calves following administration of a fentanyl transdermal patch (FTP). STUDY DESIGN: Prospective, experimental clinical study. ANIMALS: Six female Holstein calves and one male Angus calf. Four calves were healthy experimental animals and three calves were clinical patients. METHODS: Plasma fentanyl concentrations were measured in blood collected from a jugular vein...
April 11, 2018: Veterinary Anaesthesia and Analgesia
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