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https://www.readbyqxmd.com/read/28208012/hypothermia-inhibits-endothelium-independent-vascular-contractility-via-rho-kinase-inhibition
#1
Yoon Hee Chung, Keon Woong Oh, Sung Tae Kim, Eon Sub Park, Hyun Dong Je, Hyuk-Jun Yoon, Uy Dong Sohn, Ji Hoon Jeong, Hyen-Oh La
The present study was undertaken to investigate the influence of hypothermia on endothelium-independent vascular smooth muscle contractility and to determine the mechanism underlying the relaxation. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Hypothermia significantly inhibited fluoride-, thromboxane A₂-, phenylephrine-, and phorbol ester-induced vascular contractions regardless of endothelial nitric oxide synthesis, suggesting that another pathway had a direct effect on vascular smooth muscle...
February 17, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28203194/accidental-ingestion-of-nasal-packing-gauze-during-endonasal-endoscopic-dacryocystorhinostomy-under-local-anesthesia-a-case-report
#2
Yoshiyuki Kitaguchi, Jacqueline Mupas-Uy, Yasuhiro Takahashi, Kazushige Ishida, Hirohiko Kakizaki
PURPOSE: To report a case of accidental ingestion of a nasal packing gauze during endonasal endoscopic dacryocystorhinostomy (en-DCR) under local anesthesia. CASE REPORT: A 66-year-old female patient underwent an en-DCR for a right acquired nasolacrimal duct obstruction. The surgery was performed in a supine position under local anesthesia. An X-ray detectable ribbon gauze soaked in 0.02% epinephrine was placed in the middle meatus to prevent blood and liquid from flowing into the pharynx...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28160508/transvaginal-management-of-severe-pelvic-organ-prolapse-in-nulliparous-women
#3
Tsia-Shu Lo, Sukanda Jaili, Ma Clarissa Uy-Patrimonio, Nazura Bt Karim, Rami Ibrahim
AIM: The aim of this study was to evaluate the management outcomes of advanced pelvic organ prolapse (POP) in nulliparous women. METHODS: Eight nulliparous women diagnosed with POP ≥ stage 3 between January 2005 and August 2013, according to the Pelvic Organ Quantification System (POPQ), were reviewed. Seven were managed surgically and one was managed with pessary. Primary outcome was surgical objective cure (POP-Q ≤ 1) and subjective cure, defined as negative response to questions 2 and 3 on Pelvic Organ Prolapse Distress Inventory 6...
February 4, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28125813/signal-transduction-underlying-the-inhibitory-mechanism-of-fluoxetine-on-electrical-field-stimulation-response-in-rat-ileal-smooth-muscle
#4
Phyu Phyu Khin, Tin Sandar Zaw, Uy Dong Sohn
Fluoxetine (FLX), a well-known antidepressant drug under the class of selective serotonin reuptake inhibitor, exerts its action by inhibiting the reuptake of serotonin selectively. In some studies, it has been demonstrated that FLX relaxes the intestinal smooth muscle. In this study, we aimed at studying the signal transduction pathway underlying the muscle relaxation effect of FLX on electrically stimulated rat ileal muscle contraction. To investigate the possible mechanism involved, various antagonists were used...
January 27, 2017: Pharmacology
https://www.readbyqxmd.com/read/28115576/soil-transmitted-helminthiasis-and-schistosomiasis-in-children-of-poor-families-in-leyte-philippines-lessons-for-disease-prevention-and-control
#5
Harvy Joy Liwanag, Jhanna Uy, Ramil Bataller, Janis Ruth Gatchalian, Betty De La Calzada, Justine Alessandra Uy, Manuel Dayrit
OBJECTIVE:  Neglected tropical diseases (NTDs) continue to be a public health problem in the Philippines. We assessed the association of soil-transmitted helminthiasis (STH) and schistosomiasis with selected health-related and socioeconomic variables in four villages in Leyte, Philippines. METHODS:  Stool specimens from 418 adults and 533 of their children from 209 families were examined through the Kato-Katz technique. RESULTS:  STH and schistosomiasis were present in 64...
January 23, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28092909/immune-mediated-neuropathies-following-autologous-stem-cell-transplantation-for-multiple-myeloma-case-series-and-review-of-the-literature
#6
Ghulam Rehman Mohyuddin, Jacqueline Uy, Honhar Medhavi, Muhammad Salman Faisal, Muzaffar H Qazilbash
Neuropathy is a common finding in patients with multiple myeloma. Several different factors can cause neuropathy in these patients, such as the underlying disease itself, medications used for treatment, or immune-mediated processes. Immune-mediated neuropathies (IMN) consist of a heterogeneous spectrum of peripheral nerve disorders. Although IMN is associated with several hematological disorders, it remains a very rare complication of hematopoietic stem cell transplantation (HCT). We describe our experiences of 3 patients with multiple myeloma who experienced IMN following autologous HCT (auto-HCT)...
January 17, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28087457/t-cell-replete-peripheral-blood-haploidentical-hematopoietic-cell-transplantation-with-post-transplantation-cyclophosphamide-results-in-outcomes-similar-to-transplantation-from-traditionally-matched-donors-in-active-disease-acute-myeloid-leukemia
#7
Joan How, Michael Slade, Khoan Vu, John F DiPersio, Peter Westervelt, Geoffrey L Uy, Camille N Abboud, Ravi Vij, Mark A Schroeder, Todd A Fehniger, Rizwan Romee
Outcomes for patients with acute myeloid leukemia (AML) who fail to achieve complete remission remain poor. Hematopoietic cell transplantation (HCT) has been shown to induce long-term survival in AML patients with active disease. HCT is largely performed with HLA-matched unrelated or HLA-matched related donors. Recently, HCT with HLA-haploidentical related donors has been identified as a feasible option when HLA-matched donors are not immediately available. However, there are little data comparing outcomes for AML patients with active disease who receive haploidentical versus traditionally matched HCT...
January 10, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28067881/single-institution-experience-with-g-csf-mobilized-t-cell-replete-haploidentical-hematopoietic-cell-transplantation
#8
E Huselton, M Slade, J F DiPersio, P Westervelt, R Vij, G L Uy, T A Fehniger, C N Abboud, F Gao, M A Schroeder, R Romee
No abstract text is available yet for this article.
January 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28045510/anaerobic-heme-degradation-chuy-is-an-anaerobilin-reductase-that-exhibits-kinetic-cooperativity
#9
Joseph W LaMattina, Michael Delrossi, Katherine G Uy, Nicholas D Keul, David B Nix, Anudeep R Neelam, William N Lanzilotta
Heme catabolism is an important biochemical process that many bacterial pathogens utilize to acquire iron. However, tetrapyrrole catabolites can be reactive and often require further processing for transport out of the cell or conversion to another useful cofactor. In previous work, we presented in vitro evidence of an anaerobic heme degradation pathway in Escherichia coli O157:H7. Consistent with reactions that have been reported for other radical S-adenosyl-l-methionine methyltransferases, ChuW transfers a methyl group to heme by a radical-mediated mechanism and catalyzes the β-scission of the porphyrin macrocycle...
January 26, 2017: Biochemistry
https://www.readbyqxmd.com/read/28044381/the-romhilt-estes-electrocardiographic-score-predicts-sudden-cardiac-arrest-independent-of-left-ventricular-mass-and-ejection-fraction
#10
Navid Darouian, Aapo L Aro, Kumar Narayanan, Audrey Uy-Evanado, Carmen Rusinaru, Kyndaron Reinier, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: The Romhilt-Estes point score system (RE) is an established ECG criterion for diagnosing left ventricular hypertrophy (LVH). In this study, we assessed for the first time, whether RE and its components are predictive of sudden cardiac arrest (SCA) independent of left ventricular (LV) mass. METHODS: Sudden cardiac arrest (SCA) cases occurring between 2002 and 2014 in a Northwestern US metro region (catchment area approx. 1 million) were compared to geographic controls...
January 3, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28030755/epidemiology-of-infections-following-haploidentical-peripheral-blood-hematopoietic-cell-transplantation
#11
Michael Slade, Scott Goldsmith, Rizwan Romee, John F DiPersio, Erik R Dubberke, Peter Westervelt, Geoffrey L Uy, Steven J Lawrence
BACKGROUND: The use of T-cell replete haploidentical hematopoietic cell transplant (haplo-HCT) has increased substantially since the introduction of post-transplant cyclophosphamide (PTCy) regimens. Limited data exist concerning infectious complications of haplo-HCT utilizing mobilized peripheral blood (PB) hematopoietic cells. METHODS: This retrospective cohort study included all adult patients at our institution undergoing PB haplo-HCT with PTCy between June 2009 and June 2015...
November 7, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28012047/the-protective-mechanism-of-qgc-in-feline-esophageal-epithelial-cells-by-interleukin-1%C3%AE-treatment
#12
Hyun Soo Jang, Seung In Um, Sung Hee Lee, Wan Kyunn Whang, Young Sil Min, Sun Young Park, Uy Dong Sohn
In a previous study, Quercetin-3-O-β-D-glucuronopyranoside (QGC) has anti-oxidative and anti-inflammatory effects in vivo. QGC is a flavonoid glucoside extracted from Rumex Aquaticus. We investigated the downstream target proteins involved in IL-1β-stimulated ROS production and the ability of QGC to inhibit ROS production. Cell viability was determined using the MTT reduction assay. Western blot analysis was performed with antibodies to investigate the activation of three MAPKs, NF-κB, and phosphorylated IκB-α (pIB), and the expression of COX-2...
December 23, 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27991501/the-immunohistochemical-and-urodynamic-evaluation-towards-the-collagen-coated-and-non-coated-polypropylene-meshes-implanted-in-the-pelvic-wall-of-the-rats
#13
Tsia-Shu Lo, Yi-Hao Lin, Faridah Mohd Yusoff, Hsiao-Chien Chu, Wu-Chiao Hsieh, Ma Clarissa Uy-Patrimonio
Our aim is to study the inflammatory response towards the collagen-coated and non-coated polypropylene meshes in rats and the urodynamic investigation post-operatively. Forty-two female Sprague Dawley were divided into 7 groups of 6 rats; Control, Day 7 and 30 for Sham, Avaulta Plus (MPC), Perigee (MP). UDS were taken at days 7 and 30. Mesh with the vagina and bladder wall was removed and sent for immunohistochemical examination. Results showed intense inflammatory reaction on day 7 in the study groups which decreased on day 30...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27988060/syncope-and-risk-of-sudden-cardiac-arrest-in-coronary-artery-disease
#14
Aapo L Aro, Carmen Rusinaru, Audrey Uy-Evanado, Kyndaron Reinier, Derek Phan, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: Syncope has been associated with increased risk of sudden cardiac arrest (SCA) in specific patient populations, such as hypertrophic cardiomyopathy, heart failure, and long QT syndrome, but data are lacking on the risk of SCA associated with syncope among patients with coronary artery disease (CAD), the most common cause of SCA. We investigated this association among CAD patients in the community. METHODS: All cases of SCA due to CAD were prospectively identified in Portland, Oregon (population approximately 1 million) as part of the Oregon Sudden Unexpected Death Study 2002-2015, and compared to geographical controls...
March 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27986636/sleep-duration-moderates-the-association-between-insula-activation-and-risky-decisions-under-stress-in-adolescents-and-adults
#15
Jessica Phuong Uy, Adriana Galván
Insufficient sleep has been associated with increased risk-taking and poor decision-making, enhanced physiological responses to stress, and attenuated anterior insula (AI) activity to risk. The AI has also been linked to risky decision-making under acute stress. However, it is yet unknown how naturalistic sleep habits affect risky decision-making and AI activity when individuals feel stressed. In the current study, a daily diary approach was used to document participants' daily stress. Adolescents and adults reported their recent sleep duration and completed two fMRI visits during which they performed a risky decision-making task: once each when they endorsed a high and low level of stress...
December 13, 2016: Neuropsychologia
https://www.readbyqxmd.com/read/27972824/developing-a-comprehensive-culturally-sensitive-conceptual-framework-of-health-domains-in-singapore
#16
E J Uy, M Y Ow, X Xin, S C Sung, Y B Cheung, D Bautista, J Thumboo
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27972819/developing-item-pools-for-physical-functioning-social-relationships-and-positive-mindset-to-measure-health-related-quality-of-life-hrqol-in-the-singapore-population
#17
E J Uy, Y Xiao, P T Yeo, X Xin, Y Pua, G L Lee, Y H Kwan, J A Vaingankar, M Subramaniam, M F Chan, N Kumar, D Bautista, M Y Ow, P A Lim, B E Choo, Y Y Leung, A Chan, S C Sung, T C Kwek, Y B Cheung, J Thumboo
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27972813/using-best-worst-scaling-choice-experiments-to-elicit-the-most-important-domains-of-health-related-quality-of-life-hrqol-in-singapore
#18
E J Uy, D Bautista, X Xin, Y B Cheung, S Thio, J Thumboo
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27959731/tp53-and-decitabine-in-acute-myeloid-leukemia-and-myelodysplastic-syndromes
#19
John S Welch, Allegra A Petti, Christopher A Miller, Catrina C Fronick, Michelle O'Laughlin, Robert S Fulton, Richard K Wilson, Jack D Baty, Eric J Duncavage, Bevan Tandon, Yi-Shan Lee, Lukas D Wartman, Geoffrey L Uy, Armin Ghobadi, Michael H Tomasson, Iskra Pusic, Rizwan Romee, Todd A Fehniger, Keith E Stockerl-Goldstein, Ravi Vij, Stephen T Oh, Camille N Abboud, Amanda F Cashen, Mark A Schroeder, Meagan A Jacoby, Sharon E Heath, Kierstin Luber, Megan R Janke, Andrew Hantel, Niloufer Khan, Madina J Sukhanova, Randall W Knoebel, Wendy Stock, Timothy A Graubert, Matthew J Walter, Peter Westervelt, Daniel C Link, John F DiPersio, Timothy J Ley
Background The molecular determinants of clinical responses to decitabine therapy in patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) are unclear. Methods We enrolled 84 adult patients with AML or MDS in a single-institution trial of decitabine to identify somatic mutations and their relationships to clinical responses. Decitabine was administered at a dose of 20 mg per square meter of body-surface area per day for 10 consecutive days in monthly cycles. We performed enhanced exome or gene-panel sequencing in 67 of these patients and serial sequencing at multiple time points to evaluate patterns of mutation clearance in 54 patients...
November 24, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27930286/left-ventricular-geometry-and-risk-of-sudden-cardiac-arrest-in-patients-with-severely-reduced-ejection-fraction
#20
Derek Phan, Aapo L Aro, Kyndaron Reinier, Carmen Teodorescu, Audrey Uy-Evanado, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: Recent reports indicate that specific left ventricular (LV) geometric patterns predict recurrent ventricular arrhythmias in patients with implantable cardioverter-defibrillators and reduced left ventricular ejection fraction (LVEF). However, this relationship has not been evaluated among patients at risk of sudden cardiac arrest (SCA) in the general population. METHODS AND RESULTS: Adult SCA cases from the Oregon Sudden Unexpected Death Study were compared with geographic controls with no prior history of SCA...
August 18, 2016: Journal of the American Heart Association
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