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https://www.readbyqxmd.com/read/28812920/orbital-myxoma-comorbid-with-acute-myelomonocytic-leukemia
#1
Jacqueline Mupas-Uy, Yoshiyuki Kitaguchi, Yasuhiro Takahashi, Emiko Takahashi, Hirohiko Kakizaki
We report the first case of orbital myxoma in a 10-year-old girl with a history of acute myelomonocytic leukemia diagnosed at the age of 10 months. She presented with a mass in the right orbit, which was excised completely. There was no recurrence during the 6 months of follow-up.
August 16, 2017: Orbit
https://www.readbyqxmd.com/read/28797783/results-of-prospective-randomized-open-label-non-inferiority-study-of-tbo-filgrastim-granix-%C3%A2-versus-filgrastim-neupogen-%C3%A2-in-combination-with-plerixafor-for-autologous-stem-cell-mobilization-in-patients-with-multiple-myeloma-or-non-hodgkin-lymphoma
#2
Pavan Kumar Bhamidipati, Mark A Fiala, Brenda J Grossman, John F DiPersio, Keith Stokerl-Goldstein, Feng Gao, Geoffrey L Uy, Peter Westervelt, Mark A Schroeder, Amanda F Cashen, Camille N Abboud, Ravi Vij
Autologous hematopoietic stem cell transplantation (Auto- HSCT) improves survival in multiple myeloma (MM) and Non-Hodgkin lymphoma (NHL). Traditionally, filgrastim (Neupogen® - recombinant G-CSF) has been used in as a single agent or in combination with plerixafor for stem cell mobilization for auto-HSCT. In Europe, recombinant G-CSF biosimilar (Tevagrastim®) is approved for various indications similar to reference filgrastim, including stem cell mobilization for auto-HSCT; However, tbo- Filgrastim (Granix®) is registered under original biologic application and is not approved for stem cell mobilization in the USA...
August 7, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28738707/clinical-evaluation-of-combined-azacitidine-and-entinostat-on-the-induction-of-fetal-hemoglobin-in-patients-with-acute-myeloid-leukemias-and-myelodysplastic-syndromes
#3
Katharine R Press, Natalie Uy, Jeffrey Keefer, Steven D Gore, Hetty E Carraway, Sarah Sakoian, Thomas Prebet
No abstract text is available yet for this article.
July 25, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28721435/effect-of-a-combined-tai-chi-resistance-training-and-dietary-intervention-on-cognitive-function-in-obese-older-women
#4
F Xu, M J Delmonico, I E Lofgren, K M Uy, S A Maris, D Quintanilla, A G Taetzsch, J Letendre, L Mahler
Cognitive decline in older adults is a major public health problem and can compromise independence and quality of life. Exercise and diet have been studied independently and have shown to be beneficial for cognitive function, however, a combined Tai Chi, resistance training, and diet intervention and its influence on cognitive function has not been undertaken. The current study used a 12-week non-randomized research design with experiment and control groups to examine the effect of a combined Tai Chi, resistance training, and diet intervention on cognitive function in 25 older obese women...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/28711633/novel-measure-of-autonomic-remodeling-associated-with-sudden-cardiac-arrest-in-diabetes
#5
Yang Yang, Aapo L Aro, Sandeep G Nair, Reshmy Jayaraman, Kyndaron Reinier, Carmen Rusinaru, Audrey Uy-Evanado, Hirad Yarmohammadi, Jonathan Jui, Sumeet S Chugh
BACKGROUND: Diabetes is independently associated with an increased risk of sudden cardiac arrest (SCA), with a need to identify novel methods for risk stratification. Diabetic patients can develop autonomic dysfunction that has been associated with an increased risk of ventricular arrhythmogenesis and manifests as reduced heart rate variability (HRV). However, previously published studies have not accounted for resting heart rate (HR), important from both pathophysiological and prognosticating standpoints...
July 13, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28690831/patient-waiting-time-in-the-outpatient-clinic-at-a-central-surgical-hospital-of-vietnam-implications-for-resource-allocation
#6
Tho Dinh Tran, Uy Van Nguyen, Vuong Minh Nong, Bach Xuan Tran
Background: Patient waiting time is considered as a crucial parameter in the assessment of healthcare quality and patients' satisfaction towards healthcare services. Data concerning this has remained limited in Vietnam. Thus, this study aims to assess patient waiting time in the outpatient clinic in Viet Duc Hospital (Hanoi, Vietnam) in order to enable stakeholders to inform evidence-based interventions to improve the quality of healthcare services. Methods: A cross-sectional study was conducted from June 2014 to June 2015 in the outpatient clinic at Viet Duc Hospital...
2017: F1000Research
https://www.readbyqxmd.com/read/28675065/hypomethylating-agents-hma-treatment-for-myelodysplastic-syndromes-alternatives-in-the-frontline-and-relapse-settings
#7
Natalie Uy, Abhay Singh, Steven D Gore, Thomas Prebet
Hypomethylating agents (HMA) have played a pivotal role for treating myelodysplastic syndromes (MDS) over the past decade, inducing sustained hematological responses and delaying progression to leukemia. However, a vast majority of patients will experience treatment failure within 2 years, with poor prognoses and limited options, and management of this growing patient population remains unclear. Areas covered: With the introduction of new agents in the MDS field, a better understanding of the biology of MDS, and updated information on standard of care options (including allogeneic transplantation), we re-evaluate the global treatment strategy in MDS via novel agents, focusing in particular on investigational approaches for patients who fail to respond to HMA when applicable...
August 1, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28662567/electrical-risk-score-beyond-the-left-ventricular-ejection-fraction-prediction-of-sudden-cardiac-death-in-the-oregon-sudden-unexpected-death-study-and-the-atherosclerosis-risk-in-communities-study
#8
Aapo L Aro, Kyndaron Reinier, Carmen Rusinaru, Audrey Uy-Evanado, Navid Darouian, Derek Phan, Wendy J Mack, Jonathan Jui, Elsayed Z Soliman, Larisa G Tereshchenko, Sumeet S Chugh
Aims: There is an urgent need to extend sudden cardiac death (SCD) risk stratification beyond the left ventricular ejection fraction (LVEF). We evaluated whether a cumulative electrocardiogram (ECG) risk score would improve identification of individuals at high risk of SCD. Methods and results: In the community-based Oregon Sudden Unexpected Death Study (catchment population ∼1 million), 522 SCD cases with archived 12-lead ECG available (65.3 ± 14.5 years, 66% male) were compared with 736 geographical controls to assess the incremental value of multiple ECG parameters in SCD prediction...
June 26, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28660153/vascular-diseases-of-the-spleen-a-review
#9
REVIEW
Pearl Princess D Uy, Denise Marie Francisco, Anshu Trivedi, Michael O'Loughlin, George Y Wu
Vascular diseases of the spleen are relatively uncommon in the clinical practice. However, the reported incidence has been progressively increasing, probably due to advances in the imaging modalities used to detect them. This disease condition often presents with non-specific clinical manifestations, but can be associated with significant morbidity and mortality. This review article aims to provide updated clinical information on the different vascular diseases of the splenic vasculature-splenic vein thrombosis, splenic vein aneurysm, splenic artery aneurysm, splenic arteriovenous fistula, and spontaneous splenorenal shunt-in order to aid clinicians in early diagnosis and management...
June 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28659263/health-insurance-expansion-and-incidence-of-out-of-hospital-cardiac-arrest-a-pilot-study-in-a-us-metropolitan-community
#10
Eric C Stecker, Kyndaron Reinier, Carmen Rusinaru, Audrey Uy-Evanado, Jon Jui, Sumeet S Chugh
BACKGROUND: Health insurance has many benefits including improved financial security, greater access to preventive care, and better self-perceived health. However, the influence of health insurance on major health outcomes is unclear. Sudden cardiac arrest prevention represents one of the major potential benefits from health insurance, given the large impact of sudden cardiac arrest on premature death and its potential sensitivity to preventive care. METHODS AND RESULTS: We conducted a pre-post study with control group examining out-of-hospital cardiac arrest (OHCA) among adult residents of Multnomah County, Oregon (2015 adult population 636 000)...
June 28, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28643288/inhibitory-effect-of-fsllry-nh2-on-inflammatory-responses-induced-by-hydrogen-peroxide-in-hepg2-cells
#11
Yeon Joo Lee, Su Jin Kim, Kyoung Wan Kwon, Won Mo Lee, Wi Joon Im, Uy Dong Sohn
Proteinase activated receptor 2 (PAR2), which is localized in the GI tract, the respiratory system, and the kidney tubules is a G protein-coupled receptor associated with inflammation, metabolism, and disease. The aim of this study was to explore the role of PAR2 in hydrogen peroxide (H2O2)-induced HepG2 cells by using FSLLRY-NH2 a PAR2 antagonist. H2O2 treatment resulted in induction of PAR2 in esophageal, gastric, and liver cells, with the most robust response being in HepG2 cells. Furthermore, this effect was dose-dependent in HepG2 cells...
June 22, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28634555/a-rare-case-of-pneumopericardium-in-the-setting-of-tuberculous-constrictive-pericarditis
#12
Lauro L Abrahan Iv, Stephanie Martha O Obillos, Jaime Alfonso M Aherrera, Jose Donato A Magno, Celia Catherine C Uy-Agbayani, Ulysses King G Gopez, Jobelle Joyce Anne R Baldonado
A 28-year-old Filipino male was admitted due to high-grade fevers and dyspnea on a background of chronic cough and weight loss. Due to clinical and echocardiographic signs of cardiac tamponade, emergency pericardiocentesis was performed on his first hospital day. Five days after, chest radiographs showed new pockets of radiolucency within the cardiac shadow, indicative of pneumopericardium. On repeat echo, air microbubbles admixed with loculated effusion were visualized in the anterior pericardial space. Constrictive physiology was also supported by a thickened pericardium, septal bounce, exaggerated respiratory variation in AV valve inflow, and IVC plethora...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28600046/a-52-month-follow-up-on-the-transvaginal-mesh-surgery-in-vaginal-cuff-eversion
#13
Tsia-Shu Lo, Faridah Mohd Yusoff, Chuan-Chi Kao, Sukanda Jaili, Ma Clarissa Uy Patrimonio
OBJECTIVE: Transvaginal mesh anterior-posterior (TVM-AP) provides better cure rates in the surgical treatment of vaginal cuff eversion than anterior transvaginal mesh combined with sacrospinous ligament fixation (TVM-A). We determine the outcomes after TVM-A and TVM-AP surgeries in advanced vaginal cuff prolapse. MATERIALS AND METHODS: The charts of 796 women who underwent pelvic organ prolapse (POP) surgery from July 2006 to January 2012 in Chang Gung Memorial Hospitals were reviewed...
June 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28599242/ficusnotins-a-f-rare-diarylbutanoids-from-the-leaves-of-ficus-nota
#14
Felmer S Latayada, Mylene M Uy, Yui Akihara, Emi Ohta, Tatsuo Nehira, Hisashi Ômura, Shinji Ohta
Six diarylbutanoids, designated as ficusnotins A-F, with a rare carbon skeleton consisting of two aromatic rings separated by an unbranched C4-chain have been isolated from the leaves of Ficus nota (Blanco) Merr. (Moraceae). The structures were determined on the basis of spectroscopic data, as well as X-ray crystallographic analysis. The isolated compounds were evaluated for their antibacterial activity against Bacillus subtilis.
September 2017: Phytochemistry
https://www.readbyqxmd.com/read/28583150/prevalence-of-pregnancy-relevant-infections-in-a-rural-setting-of-ghana
#15
Fabian Völker, Paul Cooper, Oliver Bader, Angela Uy, Ortrud Zimmermann, Raimond Lugert, Uwe Groß
BACKGROUND: Although infectious diseases still account for a high burden of morbidity and mortality in sub-Saharan Africa, simultaneous investigations on multiple infections affecting maternal and child health are missing. METHODS: We conducted a cross-sectional, single-centre pilot study in a rural area of Ghana to assess the infectiological profile during pregnancy. Screening of 180 expectant mothers was done by vaginal swabs and serology to detect the most common pregnancy-relevant infections...
June 6, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28574191/point-of-care-ultrasound-in-haemophilia-building-a-strong-foundation-for-clinical-implementation
#16
W Lawson, M Uy, K Strike, A Iorio, N Stein, L Koziol, A Chan
No abstract text is available yet for this article.
June 2, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28569875/vectorial-extreme-events-in-vcsel-polarization-dynamics
#17
Chi-Hak Uy, Damien Rontani, Marc Sciamanna
We report on the occurrence of extreme events (EEs) in the polarization dynamics of vertical cavity surface emitting lasers with optical feedback. We have identified two types of EEs based on numerical simulations: vectorial and scalar events corresponding, respectively, to the emission of a high-power pulse in both linear polarizations simultaneously and in single linear polarization. We show that these two types of events follow the typical statistics of rogue waves. Finally, we observe that an emission in both polarizations leads to a larger generation rate of EEs with a saturation over a wide range of feedback strength by comparison to a single-polarization mode emission...
June 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28558152/diabetic-macular-oedema-evidence-based-treatment-recommendations-for-asian-countries
#18
REVIEW
Gemmy Cm Cheung, Young Hee Yoon, Lee Jen Chen, Shih Jen Chen, Tara M George, Timothy Yy Lai, Kyu Hyung Park, Sjakon G Tahija, Harvey S Uy, Tien Y Wong
Diabetic macular oedema is the most common cause of diabetic retinopathy-induced vision loss. Efficacy of anti-vascular endothelial growth factor therapy in diabetic macular oedema has been demonstrated in randomized controlled trials. An Asian-specific guideline for diabetic macular oedema treatment is needed as patients in Asia tend to present with far more advanced disease than seen elsewhere in the world. Previous reviews of diabetic macular oedema management lacked a broader assessment of anti-vascular endothelial growth factor treatment choices and newer trials...
May 30, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28550261/effect-of-apoe-%C3%AE%C2%B54-genotype-on-metabolic-biomarkers-in-aging-and-alzheimer-s-disease
#19
Jill K Morris, Roxanne Adeline Z Uy, Eric D Vidoni, Heather M Wilkins, Ashley E Archer, John P Thyfault, John M Miles, Jeffrey M Burns
Alzheimer's disease (AD) may have heterogeneous pathophysiological underpinnings, with risk factors including apolipoprotein rmvarep4 (APOE4) genotype and insulin resistance. We hypothesized that distinct phenotypes exist within AD. We examined APOE4 and metabolic biomarkers in 338 subjects (n = 213 nondemented (ND), n = 125 AD). We further characterized steady state free fatty acid (FFA) levels in a subset of 45 participants who had also participated in a hyperinsulinemic-euglycemic clamp. Insulin resistance (HOMA-IR) was elevated in AD versus ND (p = 0...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28512627/laboratory-mice-are-frequently-colonized-with-staphylococcus-aureus-and-mount-a-systemic-immune-response-note-of-caution-for-in-vivo-infection-experiments
#20
Daniel Schulz, Dorothee Grumann, Patricia Trübe, Kathleen Pritchett-Corning, Sarah Johnson, Kevin Reppschläger, Janine Gumz, Nandakumar Sundaramoorthy, Stephan Michalik, Sabine Berg, Jens van den Brandt, Richard Fister, Stefan Monecke, Benedict Uy, Frank Schmidt, Barbara M Bröker, Siouxsie Wiles, Silva Holtfreter
Whether mice are an appropriate model for S. aureus infection and vaccination studies is a matter of debate, because they are not considered as natural hosts of S. aureus. We previously identified a mouse-adapted S. aureus strain, which caused infections in laboratory mice. This raised the question whether laboratory mice are commonly colonized with S. aureus and whether this might impact on infection experiments. Publicly available health reports from commercial vendors revealed that S. aureus colonization is rather frequent, with rates as high as 21% among specific-pathogen-free mice...
2017: Frontiers in Cellular and Infection Microbiology
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