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https://www.readbyqxmd.com/read/29117413/comparison-of-wound-sealability-between-femtosecond-laser-constructed-and-manual-clear-corneal-incisions-in-patients-undergoing-cataract-surgery-a-pilot-study
#1
Harvey Siy Uy, Sunil Shah, Mark Packer
PURPOSE: To compare the sealability of femtosecond laser-constructed and manual clear corneal incisions (CCIs) in patients undergoing cataract surgery. METHODS: This prospective, randomized study included 62 eyes of 62 patients with cataract grade 1 to 2 (LOCS scale). The patients were randomly assigned (1:1) for creation of either manual CCI (with a 2.4-mm keratome) or femtosecond laser-assisted CCI (LENSAR, Inc., Orlando, FL) (31 eyes in each group) before undergoing femtosecond laser-assisted cataract surgery...
November 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29098568/the-signaling-of-protease-activated-receptor-2-activating-peptide-induced-contraction-in-cat-esophageal-smooth-muscle-cells
#2
Hyun Su Ha, Se Eun Lee, Hyun Seok Lee, Gil Hyung Kim, Chan Jong Yoon, Jong Soo Han, Ji-Yun Lee, Uy Dong Sohn
Protease-activated receptors (PARs) are a family of G protein-coupled receptors with a unique activation mechanism involving proteolytic cleavage of the extracellular N-terminal domain of the receptor. PAR2 has a contractile effect on esophageal smooth muscle. We investigate the signaling pathways of the PAR2-activating peptide (PAR2-AP) induced contraction in cat esophageal smooth muscle cells. The length of freshly isolated smooth muscle cells and permeabilized cells from feline esophagus were measured by scanning micrometry, and by confirming molecular basis via western blot analysis...
November 2, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29058375/patterns-of-infectious-complications-in-acute-myeloid-leukemia-and-myelodysplastic-syndromes-patients-treated-with-10-day-decitabine-regimen
#3
Alaa M Ali, Daniel Weisel, Feng Gao, Geoffrey L Uy, Amanda F Cashen, Meagan A Jacoby, Lukas D Wartman, Armin Ghobadi, Iskra Pusic, Rizwan Romee, Todd A Fehniger, Keith E Stockerl-Goldstein, Ravi Vij, Stephen T Oh, Camille N Abboud, Mark A Schroeder, Peter Westervelt, John F DiPersio, John S Welch
Decitabine has been explored as a reduced-intensity therapy for older or unfit patients with acute myeloid leukemia (AML). To better understand the risk of infections during decitabine treatment, we retrospectively examined the culture results from each infection-related serious adverse event that occurred among 85 AML and myelodysplastic syndromes (MDS) patients treated in a prospective clinical study using 10-day cycles of decitabine at Washington University School of Medicine. Culture results were available for 163 infection-related complications that occurred in 70 patients: 90 (55...
October 23, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29052771/standardized-radiographic-interpretation-of-thoracic-tuberculosis-in-children
#4
REVIEW
Nathan David P Concepcion, Bernard F Laya, Savvas Andronikou, Pedro A N Daltro, Marion O Sanchez, Jacqueline Austine U Uy, Timothy Reynold U Lim
There is a lack of standardized approach and terminology to classify the diverse spectrum of manifestations in tuberculosis. It is important to recognize the different clinical and radiographic patterns to guide treatment. As a result of changing epidemiology, there is considerable overlap in the radiologic presentations of primary tuberculosis and post-primary tuberculosis. In this article we promote a standardized approach in clinical and radiographic classification for children suspected of having or diagnosed with childhood tuberculosis...
September 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29046900/us-intergroup-study-of-chemotherapy-plus-dasatinib-and-allogeneic-stem-cell-transplant-in-philadelphia-chromosome-positive-all
#5
Farhad Ravandi, Megan Othus, Susan M O'Brien, Stephen J Forman, Chul S Ha, Jeffrey Y C Wong, Martin S Tallman, Elisabeth Paietta, Janis Racevskis, Geoffrey L Uy, Mary Horowitz, Naoko Takebe, Richard Little, Uma Borate, Partow Kebriaei, Laura Kingsbury, Hagop M Kantarjian, Jerald P Radich, Harry P Erba, Frederick R Appelbaum
This multicenter trial was conducted to determine whether the addition of dasatinib to chemotherapy followed by an allogeneic hematopoietic cell transplant (HCT) in patients with Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) was feasible. Patients ≥ 18 and ≤ 60 years of age with newly diagnosed Ph+ ALL received up to 8 cycles of alternating hyperCVAD and high dose cytarabine and methotrexate with dasatinib. Patients with an available matched sibling or unrelated donor underwent an allogeneic HCT in first complete remission (CR1) followed by daily dasatinib starting from day 100...
December 27, 2016: Blood Advances
https://www.readbyqxmd.com/read/29043040/marine-protected-area-restricts-demographic-connectivity-dissimilarity-in-a-marine-environment-can-function-as-a-biological-barrier
#6
Masaaki Sato, Kentaro Honda, Wilfredo H Uy, Darwin I Baslot, Tom G Genovia, Yohei Nakamura, Lawrence Patrick C Bernardo, Hiroyuki Kurokochi, Allyn Duvin S Pantallano, Chunlan Lian, Kazuo Nadaoka, Masahiro Nakaoka
The establishment of marine protected areas (MPAs) can often lead to environmental differences between MPAs and fishing zones. To determine the effects on marine dispersal of environmental dissimilarity between an MPA and fishing zone, we examined the abundance and recruitment patterns of two anemonefishes (Amphiprion frenatus and A. perideraion) that inhabit sea anemones in different management zones (i.e., an MPA and two fishing zones) by performing a field survey and a genetic parentage analysis. We found lower levels of abundance per anemone in the MPA compared to the fishing zones for both species (n = 1,525 anemones, p = ...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29039367/availability-of-computerised-medical-record-system-data-to-compare-models-of-child-health-care-in-primary-care-across-europe
#7
Harshana Liyanage, Uy Hoang, Filipa Ferreira, Denise Alexander, Michael Rigby, Mitch Blair, Simon De Lusignan
Computerised medical record (CMR) system data can be used to compare different models of health care for children. We identified sources of data from the Models of Child Health Appraised (MOCHA) project that compares family doctor led with paediatrician led and mixed models of child care using index conditions. Asthma and immunisation coverage are the first of these. We explored the extent to which an established Patient Registries Initiative (PARENT); MOCHA's own survey (MIROI); the European Centre for Disease Control (ECDC) immunisation information system survey and the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (ENCePP) registry of data sources provided data to make comparisons of child health care...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29034366/a-phase-2-study-incorporating-sorafenib-into-the-chemotherapy-for-older-adults-with-flt3-mutated-acute-myeloid-leukemia-calgb-11001
#8
Geoffrey L Uy, Sumithra J Mandrekar, Kristina Laumann, Guido Marcucci, Weiqiang Zhao, Mark J Levis, Heidi D Klepin, Maria R Baer, Bayard L Powell, Peter Westervelt, Daniel J DeAngelo, Wendy Stock, Ben Sanford, William G Blum, Clara D Bloomfield, Richard M Stone, Richard A Larson
The Cancer and Leukemia Group B (CALGB), now part of the Alliance for Clinical Trials in Oncology, conducted a multicenter, single-arm, phase 2 study in patients ≥60 years with FMS-like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukemia (AML). In this study, sorafenib was added to daunorubicin and cytarabine-based induction and consolidation chemotherapy and was also continued for 12 months of maintenance therapy. The primary end point of the study was overall survival (OS) at 1 year in the FLT3 internal tandem duplication (FLT3-ITD) cohort...
January 24, 2017: Blood Advances
https://www.readbyqxmd.com/read/28972026/interlower-and-postlower-eyelid-retractor-fat-pads-a-cadaveric-microscopic-study
#9
Jacqueline T Mupas-Uy, Yasuhiro Takahashi, Takashi Nakano, Munekazu Naito, Hiroshi Ikeda, Hidetaka Miyazaki, Hirohiko Kakizaki, Raman Malhotra
BACKGROUND: To report the histological microscopic anatomy of the interlower and postlower eyelid retractor (LER) fat pads. METHODS: In this experimental microscopic study, 31 exenterated orbits from 31 Japanese cadavers (19 right and 12 left; 15 male and 16 female; mean age of death, 81.0±8.8 years; range, 52-97 years) fixed in 10% buffered formalin were used. Masson trichrome was used to stain sagittal full sections of exenterated tissues. Microscopic examination of the lower eyelids was carried out...
September 28, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28971245/sacrospinous-ligament-fixation-for-hysteropexy-does-concomitant-anterior-and-posterior-fixation-improve-surgical-outcome
#10
Tsia-Shu Lo, Ma Clarissa Uy-Patrimonio, Wu-Chiao Hsieh, Ju-Chun Yang, Shih Yin Huang, Sandy Chua
INTRODUCTION AND HYPOTHESIS: Uterine preservation in uterine prolapse is an option for young patients. We hypothesized that sacrospinous hysteropexy (SSH) with anchorage to both the anterior and posterior cervix (SSH-ap) would have a better outcome than SSH with anchorage to the posterior cervix only (SSH-p). METHODS: This was a retrospective study including 75 patients who underwent SSH at Chang Gung Memorial Hospital between March 2008 and August 2013. Five were excluded due to incomplete data...
October 2, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28943016/serum-calcium-and-risk-of-sudden-cardiac-arrest-in-the-general-population
#11
COMPARATIVE STUDY
Hirad Yarmohammadi, Audrey Uy-Evanado, Kyndaron Reinier, Carmen Rusinaru, Harpriya Chugh, Jonathan Jui, Sumeet S Chugh
OBJECTIVE: To evaluate the potential role of low serum Ca levels in the occurrence of sudden cardiac arrest (SCA) in the community. PATIENTS AND METHODS: We compared 267 SCA cases [177 (66%) men] and 445 controls [314 (71%) men] from a large population-based study (catchment population ∼1 million individuals) in the US Northwest from February 1, 2002, through December 31, 2015. Patients were included if their age was 18 years or older with available creatinine clearance (CrCl) and serum electrolyte levels for analyses to enable adjustment for renal function...
October 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28931549/sacral-neuromodulation-blocks-pudendal-inhibition-of-reflex-bladder-activity-in-cats-insight-into-the-efficacy-of-sacral-neuromodulation-in-fowler-s-syndrome
#12
Xing Li, Jamie Uy, Michelle Yu, Shun Li, Katherine Theisen, Jeffrey Browning, Bing Shen, Jicheng Wang, James R Roppolo, William C de Groat, Changfeng Tai
This study tested the hypothesis that sacral neuromodulation, i.e. electrical stimulation of afferent axons in sacral spinal root, can block pudendal afferent inhibition of the micturition reflex. In α-chloralose anesthetized cats, pudendal nerve stimulation (PNS) at 3-5 Hz was used to inhibit bladder reflex activity while the sacral S1 or S2 dorsal root was stimulated at 15-30 Hz to mimic sacral neuromodulation and to block the bladder inhibition induced by PNS. The intensity threshold (T) for PNS or S1/S2 dorsal root stimulation (DRS) to induce muscle twitch of anal sphincter or toe was determined...
September 20, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28920650/junior-investigators-get-engaged-in-the-alliance-for-clinical-trials-in-oncology
#13
Geoffrey L Uy, Matthew H G Katz, Judy C Boughey
The success of the Alliance and the cooperative groups in the National Cancer Institute's National Clinical Trials Network is dependent on the cooperative group's ability to help recruit and train the next generation of clinical researchers.
April 2017: Bulletin of the American College of Surgeons
https://www.readbyqxmd.com/read/28918124/polyphenols-reported-to-shift-apap-induced-changes-in-mapk-signaling-and-toxicity-outcomes
#14
REVIEW
Ngoc Uy Nguyen, Brendan David Stamper
Due to its widespread availability, acetaminophen (APAP) is the leading cause for drug-induced liver injury in many countries including United States and United Kingdom. When used as recommended, APAP is relatively safe. However, in overdose cases, increased metabolism of APAP to N-acetyl-para-benzoquinoneimine (NAPQI), a reactive metabolite, leads to glutathione (GSH) depletion, oxidative stress, and cellular injury. Throughout this process, a variety of factors play important roles in propagating toxicity, including c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase (MAPK) family...
November 1, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28874594/nccn-guidelines-insights-acute-lymphoblastic-leukemia-version-1-2017
#15
Patrick A Brown, Bijal Shah, Amir Fathi, Matthew Wieduwilt, Anjali Advani, Patricia Aoun, Stefan K Barta, Michael W Boyer, Teresa Bryan, Patrick W Burke, Ryan Cassaday, Peter F Coccia, Steven E Coutre, Lloyd E Damon, Daniel J DeAngelo, Olga Frankfurt, John P Greer, Hagop M Kantarjian, Rebecca B Klisovic, Gary Kupfer, Mark Litzow, Arthur Liu, Ryan Mattison, Jae Park, Jeffrey Rubnitz, Ayman Saad, Geoffrey L Uy, Eunice S Wang, Kristina M Gregory, Ndiya Ogba
The prognosis for patients with newly diagnosed acute lymphoblastic leukemia (ALL) has improved with the use of more intensive chemotherapy regimens, tyrosine kinase inhibitors, targeted agents, and allogeneic hematopoietic cell transplantation. However, the management of relapsed or refractory (R/R) ALL remains challenging and prognosis is poor. The NCCN Guidelines for ALL provide recommendations on standard treatment approaches based on current evidence. These NCCN Guidelines Insights summarize treatment recommendations for R/R ALL and highlight important updates, and provide a summary of the panel's discussion and underlying data supporting the most recent recommendations for R/R ALL management...
September 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28855188/an-excitatory-reflex-from-the-superficial-peroneal-nerve-to-the-bladder-in-cats
#16
Michelle Yu, Jamie Uy, Xuewen Jiang, Xing Li, Cameron Jones, Bing Shen, Jicheng Wang, James R Roppolo, William C de Groat, Changfeng Tai
This study in α-chloralose anesthetized cats discovered an excitatory peroneal nerve-to-bladder reflex. A urethral catheter was used to infuse the bladder with saline and record bladder pressure changes. Electrical stimulation was applied to the superficial peroneal nerve to trigger a reflex bladder activity. With the bladder distended at a volume about 90% of bladder capacity, superficial peroneal nerve stimulation (PNS) at 1-3 Hz and threshold (T) intensity for inducing muscle twitching on the posterior thigh induced large amplitude (40-150 cmH2O) bladder contractions...
August 30, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28854506/transfusion-related-acute-lung-injury-following-pda-ligation-in-a-preterm-neonate
#17
R G LaGrandeur, M Tran, C Merchant, C Uy
Transfusion-related acute lung injury (TRALI) is a life-threatening complication of blood product transfusion characterized by sudden onset hypoxemic respiratory failure with bilateral lung infiltrates and non-cardiogenic pulmonary edema developing within 6 hours of transfusion. It is believed to be under-recognized, particularly among preterm neonates in whom co-existing developmental lung disease adds diagnostic complexity. Here we report the case of a preterm neonate who developed TRALI during a blood transfusion following PDA ligation...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28838885/text-messaging-interventions-on-cancer-screening-rates-a-systematic-review
#18
Catherine Uy, Jennifer Lopez, Chau Trinh-Shevrin, Simona C Kwon, Scott E Sherman, Peter S Liang
BACKGROUND: Despite high-quality evidence demonstrating that screening reduces mortality from breast, cervical, colorectal, and lung cancers, a substantial portion of the population remains inadequately screened. There is a critical need to identify interventions that increase the uptake and adoption of evidence-based screening guidelines for preventable cancers at the community practice level. Text messaging (short message service, SMS) has been effective in promoting behavioral change in various clinical settings, but the overall impact and reach of text messaging interventions on cancer screening are unknown...
August 24, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28826955/five-year-outcome-of-miniarc-single-incision-sling-used-in-the-treatment-of-primary-urodynamic-stress-incontinence
#19
Tsia-Shu Lo, Sandy Chua, Chuan Chi Kao, Ma Clarissa Uy-Patrimonio, Rami Ibrahim, Yiap Loong Tan
STUDY OBJECTIVE: To evaluate the effectiveness and safety of the MiniArc single-incision sling in the treatment of urodynamic stress incontinence (USI) through 5 years. DESIGN: Retrospective observational study (Canadian Task Force classification II-2). SETTING: Tertiary referral center. PATIENTS: Eighty-five patients with USI without needing concurrent procedures who underwent anti-incontinence surgery using the MiniArc SIMS from February 2010 to December 2011...
August 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28812920/orbital-myxoma-comorbid-with-acute-myelomonocytic-leukemia
#20
Jacqueline Mupas-Uy, Yoshiyuki Kitaguchi, Yasuhiro Takahashi, Emiko Takahashi, Hirohiko Kakizaki
We report the first case of orbital myxoma in a 10-year-old girl with a history of acute myelomonocytic leukemia diagnosed at the age of 10 months. She presented with a mass in the right orbit, which was excised completely. There was no recurrence during the 6 months of follow-up.
August 16, 2017: Orbit
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