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https://www.readbyqxmd.com/read/28643288/inhibitory-effect-of-fsllry-nh2-on-inflammatory-responses-induced-by-hydrogen-peroxide-in-hepg2-cells
#1
Yeon Joo Lee, Su Jin Kim, Kyoung Wan Kwon, Won Mo Lee, Wi Joon Im, Uy Dong Sohn
Proteinase activated receptor 2 (PAR2), which is localized in the GI tract, the respiratory system, and the kidney tubules is a G protein-coupled receptor associated with inflammation, metabolism, and disease. The aim of this study was to explore the role of PAR2 in hydrogen peroxide (H2O2)-induced HepG2 cells by using FSLLRY-NH2 a PAR2 antagonist. H2O2 treatment resulted in induction of PAR2 in esophageal, gastric, and liver cells, with the most robust response being in HepG2 cells. Furthermore, this effect was dose-dependent in HepG2 cells...
June 22, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28634555/a-rare-case-of-pneumopericardium-in-the-setting-of-tuberculous-constrictive-pericarditis
#2
Lauro L Abrahan Iv, Stephanie Martha O Obillos, Jaime Alfonso M Aherrera, Jose Donato A Magno, Celia Catherine C Uy-Agbayani, Ulysses King G Gopez, Jobelle Joyce Anne R Baldonado
A 28-year-old Filipino male was admitted due to high-grade fevers and dyspnea on a background of chronic cough and weight loss. Due to clinical and echocardiographic signs of cardiac tamponade, emergency pericardiocentesis was performed on his first hospital day. Five days after, chest radiographs showed new pockets of radiolucency within the cardiac shadow, indicative of pneumopericardium. On repeat echo, air microbubbles admixed with loculated effusion were visualized in the anterior pericardial space. Constrictive physiology was also supported by a thickened pericardium, septal bounce, exaggerated respiratory variation in AV valve inflow, and IVC plethora...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28600046/a-52-month-follow-up-on-the-transvaginal-mesh-surgery-in-vaginal-cuff-eversion
#3
Tsia-Shu Lo, Faridah Mohd Yusoff, Chuan-Chi Kao, Sukanda Jaili, Ma Clarissa Uy Patrimonio
OBJECTIVE: Transvaginal mesh anterior-posterior (TVM-AP) provides better cure rates in the surgical treatment of vaginal cuff eversion than anterior transvaginal mesh combined with sacrospinous ligament fixation (TVM-A). We determine the outcomes after TVM-A and TVM-AP surgeries in advanced vaginal cuff prolapse. MATERIALS AND METHODS: The charts of 796 women who underwent pelvic organ prolapse (POP) surgery from July 2006 to January 2012 in Chang Gung Memorial Hospitals were reviewed...
June 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28599242/ficusnotins-a-f-rare-diarylbutanoids-from-the-leaves-of-ficus-nota
#4
Felmer S Latayada, Mylene M Uy, Yui Akihara, Emi Ohta, Tatsuo Nehira, Hisashi Ômura, Shinji Ohta
Six diarylbutanoids, designated as ficusnotins A-F, with a rare carbon skeleton consisting of two aromatic rings separated by an unbranched C4-chain have been isolated from the leaves of Ficus nota (Blanco) Merr. (Moraceae). The structures were determined on the basis of spectroscopic data, as well as X-ray crystallographic analysis. The isolated compounds were evaluated for their antibacterial activity against Bacillus subtilis.
June 6, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28583150/prevalence-of-pregnancy-relevant-infections-in-a-rural-setting-of-ghana
#5
Fabian Völker, Paul Cooper, Oliver Bader, Angela Uy, Ortrud Zimmermann, Raimond Lugert, Uwe Groß
BACKGROUND: Although infectious diseases still account for a high burden of morbidity and mortality in sub-Saharan Africa, simultaneous investigations on multiple infections affecting maternal and child health are missing. METHODS: We conducted a cross-sectional, single-centre pilot study in a rural area of Ghana to assess the infectiological profile during pregnancy. Screening of 180 expectant mothers was done by vaginal swabs and serology to detect the most common pregnancy-relevant infections...
June 6, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28574191/point-of-care-ultrasound-in-haemophilia-building-a-strong-foundation-for-clinical-implementation
#6
W Lawson, M Uy, K Strike, A Iorio, N Stein, L Koziol, A Chan
No abstract text is available yet for this article.
June 2, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28569875/vectorial-extreme-events-in-vcsel-polarization-dynamics
#7
Chi-Hak Uy, Damien Rontani, Marc Sciamanna
We report on the occurrence of extreme events (EEs) in the polarization dynamics of vertical cavity surface emitting lasers with optical feedback. We have identified two types of EEs based on numerical simulations: vectorial and scalar events corresponding, respectively, to the emission of a high-power pulse in both linear polarizations simultaneously and in single linear polarization. We show that these two types of events follow the typical statistics of rogue waves. Finally, we observe that an emission in both polarizations leads to a larger generation rate of EEs with a saturation over a wide range of feedback strength by comparison to a single-polarization mode emission...
June 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28558152/diabetic-macular-oedema-evidence-based-treatment-recommendations-for-asian-countries
#8
REVIEW
Gemmy Cm Cheung, Young Hee Yoon, Lee Jen Chen, Shih Jen Chen, Tara M George, Timothy Yy Lai, Kyu Hyung Park, Sjakon G Tahija, Harvey S Uy, Tien Y Wong
Diabetic macular oedema is the most common cause of diabetic retinopathy-induced vision loss. Efficacy of anti-vascular endothelial growth factor therapy in diabetic macular oedema has been demonstrated in randomized controlled trials. An Asian-specific guideline for diabetic macular oedema treatment is needed as patients in Asia tend to present with far more advanced disease than seen elsewhere in the world. Previous reviews of diabetic macular oedema management lacked a broader assessment of anti-vascular endothelial growth factor treatment choices and newer trials...
May 30, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28550261/effect-of-apoe-%C3%AE%C2%B54-genotype-on-metabolic-biomarkers-in-aging-and-alzheimer-s-disease
#9
Jill Morris K, Roxanne Adeline Z Uy, Eric D Vidoni, Heather M Wilkins, Ashley E Archer, John P Thyfault, John M Miles, Jeffrey M Burns
Alzheimer's disease (AD) may have heterogeneous pathophysiological underpinnings, with risk factors including apolipoprotein rmvarep4 (APOE4) genotype and insulin resistance. We hypothesized that distinct phenotypes exist within AD. We examined APOE4 and metabolic biomarkers in 338 subjects (n = 213 nondemented (ND), n = 125 AD). We further characterized steady state free fatty acid (FFA) levels in a subset of 45 participants who had also participated in a hyperinsulinemic-euglycemic clamp. Insulin resistance (HOMA-IR) was elevated in AD versus ND (p = 0...
May 25, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28512627/laboratory-mice-are-frequently-colonized-with-staphylococcus-aureus-and-mount-a-systemic-immune-response-note-of-caution-for-in-vivo-infection-experiments
#10
Daniel Schulz, Dorothee Grumann, Patricia Trübe, Kathleen Pritchett-Corning, Sarah Johnson, Kevin Reppschläger, Janine Gumz, Nandakumar Sundaramoorthy, Stephan Michalik, Sabine Berg, Jens van den Brandt, Richard Fister, Stefan Monecke, Benedict Uy, Frank Schmidt, Barbara M Bröker, Siouxsie Wiles, Silva Holtfreter
Whether mice are an appropriate model for S. aureus infection and vaccination studies is a matter of debate, because they are not considered as natural hosts of S. aureus. We previously identified a mouse-adapted S. aureus strain, which caused infections in laboratory mice. This raised the question whether laboratory mice are commonly colonized with S. aureus and whether this might impact on infection experiments. Publicly available health reports from commercial vendors revealed that S. aureus colonization is rather frequent, with rates as high as 21% among specific-pathogen-free mice...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28476490/phase-i-ii-study-of-intravenous-plerixafor-added-to-a-mobilization-regimen-of-granulocyte-colony-stimulating-factor-in-lymphoma-patients-undergoing-autologous-stem-cell-collection
#11
Amanda F Cashen, Michael Rettig, Feng Gao, Angela Smith, Camille Abboud, Keith Stockerl-Goldstein, Ravi Vij, Geoffrey Uy, Peter Westervelt, John DiPersio
Plerixafor, given subcutaneously with granulocyte colony-stimulating factor (G-CSF), improves autologous stem cell collection in patients with lymphoma and multiple myeloma. Intravenous (i.v.) administration of plerixafor allows administration of plerixafor on the same day as pheresis and it may improve stem cell collection. The primary objectives of this phase I/II study were to determine the maximum tolerated dose of i.v. plerixafor and the efficacy of i.v. plerixafor + G-CSF to mobilize ≥ 2 × 10(6) CD34(+) cells/kg from patients with lymphoma...
May 2, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28475606/shaping-innovations-in-long-term-care-for-stroke-survivors-with-multimorbidity-through-stakeholder-engagement
#12
Euan Sadler, Talya Porat, Iain Marshall, Uy Hoang, Vasa Curcin, Charles D A Wolfe, Christopher McKevitt
BACKGROUND: Stroke, like many long-term conditions, tends to be managed in isolation of its associated risk factors and multimorbidity. With increasing access to clinical and research data there is the potential to combine data from a variety of sources to inform interventions to improve healthcare. A 'Learning Health System' (LHS) is an innovative model of care which transforms integrated data into knowledge to improve healthcare. The objective of this study is to develop a process of engaging stakeholders in the use of clinical and research data to co-produce potential solutions, informed by a LHS, to improve long-term care for stroke survivors with multimorbidity...
2017: PloS One
https://www.readbyqxmd.com/read/28473620/prognostic-and-biologic-significance-of-long-non-coding-rna-profiling-in-younger-adults-with-cytogenetically-normal-acute-myeloid-leukemia
#13
Dimitrios Papaioannou, Deedra Nicolet, Stefano Volinia, Krzysztof Mrózek, Pearlly Yan, Ralf Bundschuh, Andrew J Carroll, Jessica Kohlschmidt, William Blum, Bayard L Powell, Geoffrey L Uy, Jonathan E Kolitz, Eunice S Wang, Ann-Kathrin Eisfeld, Shelley J Orwick, David M Lucas, Michael A Caligiuri, Richard M Stone, John C Byrd, Ramiro Garzon, Clara D Bloomfield
Long non-coding RNAs are a novel class of RNA molecules, which are increasingly recognized as important molecular players in solid and hematologic malignancies. Herein we investigated whether long non-coding RNA expression is associated with clinical and molecular features, as well as outcome of younger adults (aged <60 years) with de novo cytogenetically normal acute myeloid leukemia. Whole transcriptome profiling (RNA-seq) was performed in a training (n=263) and a validation set (n=114). Using the training set, we identified 24 long non-coding RNAs associated with event-free survival...
May 4, 2017: Haematologica
https://www.readbyqxmd.com/read/28461776/therapeutic-effects-of-orally-administered-cjlp55-for-atopic-dermatitis-via-the-regulation-of-immune-response
#14
Kyeong Eun Hyung, Soo Jeong Kim, Ye Won Jang, Da Kyoung Lee, Kee Hyeob Hyun, Byoung Seok Moon, Bongjoon Kim, Heeyoon Ahn, So-Young Park, Uy Dong Sohn, Eon Sub Park, Kwang Woo Hwang
Atopic dermatitis (AD) is an inflammatory skin condition accompanied by symptoms such as edema and hemorrhage. Kimchi is a traditional fermented Korean dish consisting of various probiotics. In this study, the therapeutic effect of Lactobacillus plantarum CJLP55 isolated from Kimchi was studied in AD-induced mice. Orally administered Lactobacillus strain, CJLP55, suppressed AD symptoms and high serum IgE levels. CJLP55 administration reduced the thickness of the epidermis, infiltration of mast cells and eosinophils into the skin lesion, enlargement of axillary lymph nodes, and increase in cell population in axillary lymph nodes...
May 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28431059/cardiac-structural-and-functional-profile-of-patients-with-delayed-qrs-transition-zone-and-sudden-cardiac-death
#15
Aapo L Aro, Derek Phan, Carmen Teodorescu, Audrey Uy-Evanado, Kyndaron Reinier, Karen Gunson, Jonathan Jui, Heikki V Huikuri, Sumeet S Chugh
Aims: Delayed QRS transition zone in the precordial leads of the 12-lead electrocardiogram (ECG) has been recently associated with increased risk of sudden cardiac death (SCD), but the underlying mechanisms are unknown. We correlated echocardiographic findings with ECG and clinical characteristics to investigate how alterations in cardiac structure and function contribute to this risk marker. Methods and Results: From the ongoing population-based Oregon Sudden Unexpected Death Study (catchment population ∼1 million), SCD cases with prior ECG available (n = 627) were compared with controls (n = 801)...
April 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28428223/glutamatergic-mechanisms-involved-in-bladder-overactivity-and-pudendal-neuromodulation-in-cats
#16
Jamie Uy, Michelle Yu, Xuewen Jiang, Cameron Jones, Bing Shen, Jicheng Wang, James R Roppolo, William C de Groat, Changfeng Tai
The involvement of ionotropic glutamate receptors in bladder overactivity and pudendal neuromodulation was determined in α-chloralose anesthetized cats by intravenously administering MK801 (a NMDA receptor antagonist) or CP465022 (an AMPA receptor antagonist). Infusion of 0.5% acetic acid (AA) into the bladder produced bladder overactivity. In the first group of 5 cats, bladder capacity was significantly (P < 0.05) reduced to 55.3±10.0% of saline control by AA irritation. Pudendal nerve stimulation (PNS) significantly (P < 0...
July 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28401069/a-novel-restraint-device-for-injection-of-galleria-mellonella-larvae-that-minimizes-the-risk-of-accidental-operator-needle-stick-injury
#17
James P Dalton, Benedict Uy, Simon Swift, Siouxsie Wiles
Larvae of the insect Galleria mellonella are increasingly being used for studying pathogenic microbes and their virulence mechanisms, and as a rapid model for screening novel antimicrobial agents. The larvae (waxworms) are most frequently infected by injection of pathogenic organisms into the haemocoel through the insect's prolegs. The mostly widely used method for restraining the waxworms for injection is by grasping them between the operator's fingers, which puts the operator at risk of needle stick injury, an important consideration when working with highly pathogenic and/or drug-resistant microorganisms...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28381033/non-local-correlations-via-chaotic-itinerancy-in-vcsel-with-optical-feedback
#18
Chi-Hak Uy, Damien Rontani, Stefan Breuer, Marc Sciamanna
Similar to edge-emitting lasers, vertical cavity surface emitting lasers (VCSELs) subjected to optical feedback are known for exhibiting erratic fluctuations of their optical power at slow and fast time scales; these are called low-frequency fluctuations (LFF). Here, we demonstrate both experimentally and numerically that the chaotic itinerancy in phase space associated with LFF has a deep connection with the creation of non-local correlations at multiple time scales between the two linear polarization modes...
March 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28370617/genomic-evidence-for-convergent-evolution-of-a-key-trait-underlying-divergence-in-island-birds
#19
Elizabeth A Cooper, J Albert C Uy
Reproductive isolation can be initiated by changes in one or a few key traits that prevent random mating among individuals in a population. During the early stages of speciation, when isolation is often incomplete, there will be a heterogeneous pattern of differentiation across regions of the genome between diverging populations, with loci controlling these key traits appearing the most distinct as a result of strong diversifying selection. In this study, we used Illumina-sequenced ddRAD tags to identify genome-wide patterns of differentiation in three recently-diverged island populations of the Monarcha castaneiventris ycatcher of the Solomon Islands...
March 28, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28370456/predictors-for-detrusor-overactivity-following-extensive-vaginal-pelvic-reconstructive-surgery
#20
Tsia-Shu Lo, Shailaja Nagashu, Wu-Chiao Hsieh, Ma Clarissa Uy-Patrimonio, Lin Yi-Hao
AIM: This study aims to identify the predictors for detrusor overactivity (DO) in women following extensive vaginal pelvic reconstructive surgery (PRS) for advanced pelvic organ prolapse (POP). METHODS: We enrolled 1503 women who had prolapse POP-Q stage ≥ 3 and underwent vaginal PRS with or without MUS from January 2006 to December 2015. All subjects completed a 72-h voiding diary, IIQ-7, UDI-6, POPDI-6, and PISQ-12. Urodynamics (UDS) was performed pre- and post-operatively...
March 31, 2017: Neurourology and Urodynamics
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