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https://www.readbyqxmd.com/read/29770497/relationship-between-the-ulnar-nerve-and-the-branches-of-the-radial-nerve-to-the-medial-head-of-the-triceps-brachii-muscle
#1
Cho Sh, Chung Ih, Lee Uy
One branch of the radial nerve to the medial head of the triceps brachii muscle (MHN) has been described as accompanying or joining the ulnar nerve. Mostly two MHN branches have been reported, with some reports of one; however, the topographical anatomy is not well documented. We dissected 52 upper limbs from adult cadavers and found one, two, and three MHN branches in 9.6%, 80.8%, and 9.6% of cases, respectively. The MHN accompanying the ulnar nerve was always the superior MHN. The relationship between the ulnar nerve and the MHN was classified into four types according to whether the MHN was enveloped along with the ulnar nerve in the connective tissue sheath and whether it was in contact with the ulnar nerve...
May 17, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29765150/phase-i-studies-of-azd1208-a-proviral-integration-moloney-virus-kinase-inhibitor-in-solid-and-haematological-cancers
#2
Jorge Cortes, Kenji Tamura, Daniel J DeAngelo, Johann de Bono, David Lorente, Mark Minden, Geoffrey L Uy, Hagop Kantarjian, Lisa S Chen, Varsha Gandhi, Robert Godin, Karen Keating, Kristen McEachern, Karthick Vishwanathan, Janet Elizabeth Pease, Emma Dean
BACKGROUND: Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated in patients with recurrent or refractory acute myeloid leukaemia (AML) or advanced solid tumours. METHODS: Two dose-escalation studies were performed to evaluate the safety and tolerability, and to define the maximum tolerated dose (MTD), of AZD1208 in AML and solid tumours...
May 16, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29745890/pattern-of-muscle-involvement-in-inclusion-body-myositis-a-sonographic-study
#3
Jemima Albayda, Lisa Christopher-Stine, Clifton O Bingham Iii, Julie J Paik, Eleni Tiniakou, Seth Billings, O Manny Uy, Philippe Burlina
OBJECTIVES: Imaging plays a role in myositis assessment by detecting muscle changes indicative of pathology. This study was conducted to determine the ultrasonographic pattern of muscle involvement in patients with inclusion body myositis (IBM) through an assessment of muscle echointensity. METHODS: Sixty-two individuals were consecutively studied, 18 with IBM, 16 with polymyositis or dermatomyositis and 28 normal controls. Standardised scans were completed bilaterally for the deltoids, biceps, flexor digitorum profundus (FDP), flexor carpi ulnaris, rectus femoris, tibialis anterior and gastrocnemius assessing for muscle echointensity changes...
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29719450/exposure-to-835-mhz-rf-emf-decreases-the-expression-of-calcium-channels-inhibits-apoptosis-but-induces-autophagy-in-the-mouse-hippocampus
#4
Ju Hwan Kim, Uy Dong Sohn, Hyung-Gun Kim, Hak Rim Kim
The exponential increase in the use of mobile communication has triggered public concerns about the potential adverse effects of radiofrequency electromagnetic fields (RF-EMF) emitted by mobile phones on the central nervous system (CNS). In this study, we explored the relationship between calcium channels and apoptosis or autophagy in the hippocampus of C57BL/6 mice after RF-EMF exposure with a specific absorption rate (SAR) of 4.0 W/kg for 4 weeks. Firstly, the expression level of voltage-gated calcium channels (VGCCs), a key regulator of the entry of calcium ions into the cell, was confirmed by immunoblots...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29713210/inotuzumab-ozogamicin-in-the-treatment-of-relapsed-refractory-acute-b-cell-lymphoblastic-leukemia
#5
REVIEW
Natalie Uy, Michelle Nadeau, Maximilian Stahl, Amer M Zeidan
The improvement in outcomes of adult patients with acute lymphoblastic leukemia (ALL) has been modest, with the exception of Philadelphia chromosome-positive disease, despite advances in supportive care and stem cell transplantation. The recent approvals of novel agents, including the bispecific T-cell engager blinatumomab, the antibody-drug conjugate inotuzumab ozogamicin, and chimeric antigen receptor T-cell products are changing the management of B-ALL, which traditionally relied on chemotherapy-based approaches...
2018: Journal of Blood Medicine
https://www.readbyqxmd.com/read/29703077/surface-wetting-driven-separation-of-surfactant-stabilized-water-oil-emulsions
#6
Qian Zhang, Lei Li, Yanxiang Li, Lixia Cao, Chuanfang Yang
Four fluorocarbon polymers including PTFE and PVDF were coated respectively on a stainless steel felt to separate emulsified water droplets from ultralow sulfur diesel fuels (ULSD). The original fuel treated with clay to remove additives was additized again with four known surfactants including Pentaerythrityoleate, (octadecadienoic acid) dipolymer, (octadecadienoic acid) tripolymer and monoolein individually. The different surfactants adsorbed on the fuel-water interface reduce the interfacial intension with different intensity...
April 27, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29701747/cluster-locator-online-analysis-and-visualization-of-gene-clustering
#7
Flavio Pazos Obregón, Pablo Soto, José Luis Lavín, Ana Rosa Cortázar, Rosa Barrio, Ana María Aransay, Rafael Cantera
Summary: Genes sharing functions, expression patterns or quantitative traits are not randomly distributed along eukaryotic genomes. In order to study the distribution of genes that share a given feature, we present Cluster Locator, an online analysis and visualization tool. Cluster Locator determines the number, size and position of all the clusters formed by the protein-coding genes on a list according to a given maximum gap, the percentage of gene clustering of the list and its statistical significance...
April 25, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29689740/pilot-feasibility-study-to-detect-mesenchymal-stem-cell-biomarkers-of-bronchopulmonary-dysplasia-in-the-tracheal-aspirate-fluid-of-preterm-infants
#8
R G LaGrandeur, M Singhal, F Bany-Mohammed, C Uy, R Koeppel, F Zaldivar, F Haddad, A Nalbandian, P Donovan, D M Cooper, M Aslam
OBJECTIVE: This study aimed to detect novel mesenchymal stem cell peptides/biomarkers of bronchopulmonary dysplasia (BPD) in the tracheal aspirate fluid (TAF) of preterm infants. STUDY DESIGN: Participants included infants less than 32 weeks' gestational age or birth weight under 1500 grams who required endotracheal intubation and mechanical ventilation within first 24 hours of life. TAF sample collection was performed at the time of the first clinically indicated routine suctioning...
2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29677923/profiling-databases-to-facilitate-comparison-of-child-health-systems-across-europe-using-standardised-quality-markers
#9
Harshana Liyanage, Stacy Shinneman, Uy Hoang, Filipa Ferreira, Denise Alexander, Michael Rigby, Mitch Blair, Simon de Lusignan
Models of child primary health care vary across Europe. There are three categories, primary care paediatricians, general practitioner based, or mixed. This paper describes the metadata schema used in the profiling process of candidate data sources for appraisal for the Models of Child Health Appraised (MOCHA) project using the MOCHA International Research Opportunity Instrument (MIROI). The ten clinical indicators included: asthma, antibiotic stewardship, immunisation, rickets, diarrhea, epilepsy, depression, ADHD, enuresis and care of women during pregnancy...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29674325/adenylate-cyclase-type-9-adcy9-inactivation-protects-from-atherosclerosis-only-in-the-absence-of-cholesteryl-ester-transfer-protein-cetp
#10
Yohann Rautureau, Vanessa Deschambault, Marie-Ève Higgins, Daniel Rivas, Mélanie Mecteau, Pascale Geoffroy, Géraldine Miquel, Kurunradeth Uy, Rocio Sanchez, Véronique Lavoie, Geneviève Brand, Audrey Nault, Pierre-Marc Williams, Maria Laura Suarez, Nolwenn Merlet, Line Lapointe, Natacha Duquette, Marc-Antoine Gillis, Samaneh Samami, Gaétan Mayer, Philippe Pouliot, Adeline Raignault, Foued Maafi, Mathieu R Brodeur, Sylvie Levesque, Marie-Claude Guertin, Marie-Pierre Dubé, Éric Thorin, David Rhainds, Éric Rhéaume, Jean-Claude Tardif
Background -Pharmacogenomic studies have shown that ADCY9 genotype determines the effects of the cholesteryl ester transfer protein (CETP) inhibitor dalcetrapib on cardiovascular events and atherosclerosis imaging. The underlying mechanisms responsible for the interactions between ADCY9 and CETP activity have not yet been determined. Methods - Adcy9 -inactivated ( Adcy9 Gt/Gt ) and wild-type (WT) mice, that were or not transgenic for the CETP gene (CETPtg Adcy9 Gt/Gt and CETPtg Adcy9 WT ), were submitted to an atherogenic protocol (injection of an AAV8 expressing a PCSK9 gain-of-function variant and 0...
April 19, 2018: Circulation
https://www.readbyqxmd.com/read/29673679/trans-vaginal-mesh-surgery-for-management-of-recurrent-pelvic-organ-prolapse-following-abdominal-sacrocolpopexy
#11
Tsia-Shu Lo, Rami Ibrahim, Nazura Bt Karim, Enie Akhtar Nawawi, Ma Clarissa Uy-Patrimonio
OBJECTIVE: To evaluate the outcome of transvaginal mesh surgery as a management of recurrent pelvic organ prolapse, in patients previously treated with sacrocolpopexy. CASE REPORT: A series of three patients who developed recurrent pelvic organ prolapse more than 9 years after sacrocolpopexy. A 50-year-old and two 77-year-old patients who presented with recurrent pelvic organ prolapse at 9, 15 and 17 years, respectively after the primary abdominal sacrocolpopexy were managed by transvaginal mesh surgery...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29664135/clinical-outcomes-of-detrusor-underactivity-in-female-with-advanced-pelvic-organ-prolapse-following-vaginal-pelvic-reconstructive-surgery
#12
Tsia-Shu Lo, Sandy Chua, Ma Clarissa Uy-Patrimonio, Chuan C Kao, Chih H Lin
AIM: To determine the impact of vaginal pelvic reconstructive surgery (PRS) on detrusor underactivity (DU) patients having advanced pelvic organ prolapse (POP). METHODS: A retrospective study of patients who underwent PRS for advanced POP (POP-Q ≥ 3) with DU. Data regarding preoperative evaluation, surgical procedure, and post-operative management were collated. Patients were considered to have DU when detrusor pressure at maximum flow (Pdet Qmax ) was ≤10 cmH2 0 and peak flow rate (Qmax ) of ≤12 mL/s...
April 17, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29577100/lagophthalmos-caused-by-cicatricial-adhesion-of-orbital-adipose-tissue-to-orbital-roof-a-case-report
#13
Yoshiyuki Kitaguchi, Jacqueline Mupas-Uy, Yasuhiro Takahashi, Hirohiko Kakizaki
Purpose: To report a case of lagophthalmos caused by cicatricial adhesion of orbital adipose tissue to the orbital roof. Observations: A 23-year-old female was presented with right lagophthalmos. Five months prior to consult at our clinic, she suffered from a penetrating trauma to the frontal lobe of the brain through the right orbital roof with cerebrospinal fluid leakage. Decompressive craniectomy was performed immediately after the injury using a coronal incision, which was followed by reconstruction with an artificial bone 1 month later...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29560256/reflections-on-the-use-of-the-world-health-organization-s-who-onehealth-tool-implications-for-health-planning-in-low-and-middle-income-countries-lmics
#14
John Q Wong, Nel Jason Haw, Jhanna Uy, Diana Beatriz Bayani
The World Health Organization (WHO) launched the OneHealth Tool (OHT) to help low and middle income countries to develop their capacities for sector-wide priority setting. In 2016, we sought to use the OHT to aid the Philippine Health Insurance Corporation (PHIC), the national health insurer of the Philippines, in decisions to expand benefit packages using cost-effectiveness analyses. With technical support from the WHO, we convened health planning officers from the Philippine Department of Health (DOH) and the Philippine Health Insurance Corporation (PHIC) conduct generalized cost-effective analyses (GCEA) of selected un-financed noncommunicable disease interventions using OHT...
2018: F1000Research
https://www.readbyqxmd.com/read/29537118/point-of-care-ultrasonography-in-haemophilia-care-training-and-competency-for-muscular-haematomas
#15
K Strike, M Uy, W Lawson, S Squire, A Iorio, N Stein, S Jackson, A Chan
No abstract text is available yet for this article.
March 14, 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29535882/robot-assisted-thoracoscopic-resection-of-a-posterior-mediastinal-mullerian-cyst
#16
Calvin Chao, Vijay Vanguri, Karl Uy
First described in 2005, the Mullerian derived cyst in the mediastinum is a rare finding with few subsequent reports. We report a case of Mullerian cyst occurring in the mediastinum of a 49-year-old female that was resected by robot-assisted thoracoscopic surgery. To our knowledge, this is the first report of robot-assisted resection of Hattori's cyst. Histopathologic analysis revealed ciliated Mullerian-type tubal epithelium positive for paired box gene 8 (PAX8), estrogen receptor (ER), and progesterone receptor (PR), confirming Mullerian differentiation...
2018: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/29503949/cystic-mucosa-associated-lymphoid-tissue-lymphoma-of-lacrimal-gland-associated-with-vision-loss-a-case-report
#17
Jacqueline Mupas-Uy, Yoshiyuki Kitaguchi, Yasuhiro Takahashi, Emiko Takahashi, Hirohiko Kakizaki
Purpose: To report an atypical case of cystic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) of lacrimal gland associated with vision loss. Observations: An 89-year-old woman was presented with a rapidly progressing proptosis, lagophthalmos, and vision loss. Endophthalmitis was also present. Computed tomography scan images showed a hyperdense mass with hypodense cystic areas occupying the superolateral orbit, which displaced the globe antero-inferiorly with optic nerve compression and stretching...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29463072/the-effects-of-donepezil-an-acetylcholinesterase-inhibitor-on-impaired-learning-and-memory-in-rodents
#18
Chang Yell Shin, Hae-Sun Kim, Kwang-Ho Cha, Dong Han Won, Ji-Yun Lee, Sun Woo Jang, Uy Dong Sohn
A previous study in humans demonstrated the sustained inhibitory effects of donepezil on acetylcholinesterase (AChE) activity; however, the effective concentration of donepezil in humans and animals is unclear. This study aimed to characterize the effective concentration of donepezil on AChE inhibition and impaired learning and memory in rodents. A pharmacokinetic study of donepezil showed a mean peak plasma concentration of donepezil after oral treatment (3 and 10 mg/kg) of approximately 1.2 ± 0.4 h and 1...
May 1, 2018: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29458888/ureterovaginal-fistula-a-complication-of-a-vaginal-foreign-body
#19
Tsia-Shu Lo, Sukanda Bin Jaili, Rami Ibrahim, Chuan Chi Kao, Ma Clarissa Uy-Patrimonio
OBJECTIVE: To know the diagnostic tools and proper management of ureterovaginal fistula following neglected vaginal foreign body in order to achieve optimal outcome. CASE REPORT: A case of ureterovaginal fistula associated with a neglected vaginal foreign body. The patient was complaining of a foul-smelling vaginal discharge and lower abdominal pain. On vaginal examination, a hard and large foreign body was found. Examination under anesthesia was performed, and an aerosol cap was removed from her vagina...
February 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29435107/discovery-and-functional-implications-of-a-mir-29b-1-mir-29a-cluster-polymorphism-in-acute-myeloid-leukemia
#20
Apollinaire Ngankeu, Parvathi Ranganathan, Violaine Havelange, Deedra Nicolet, Stefano Volinia, Bayard L Powell, Jonathan E Kolitz, Geoffrey L Uy, Richard M Stone, Steven M Kornblau, Michael Andreeff, Carlo M Croce, Clara D Bloomfield, Ramiro Garzon
We previously reported that microRNA (miR)-29b is down-regulated and has a tumor suppressor role in acute myeloid leukemia (AML). However, little is known about the mechanisms responsible for miR-29b expression downregulation in AML. In this work we screened for mutations that could affect miR-29b expression. Using Sanger sequencing, we identified a germline thymidine (T) base deletion within the miR-29b-1/miR-29a cluster precursor in 16% of AML patients. Remarkably we found a significant enrichment for the presence of the miR-29 polymorphism in core binding factor (CBF) newly diagnosed AML patients ( n = 61/303; 20%) with respect to age, sex and race matched controls ( n = 43/402:11%, P < 0...
January 12, 2018: Oncotarget
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