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https://www.readbyqxmd.com/read/28092909/immune-mediated-neuropathies-following-autologous-stem-cell-transplantation-for-multiple-myeloma-case-series-and-review-of-the-literature
#1
Ghulam Rehman Mohyuddin, Jacqueline Uy, Honhar Medhavi, Muhammad Salman Faisal, Muzaffar H Qazilbash
Neuropathy is a common finding in patients with multiple myeloma. Several different factors can cause neuropathy in these patients, such as the underlying disease itself, medications used for treatment, or immune-mediated processes. Immune-mediated neuropathies (IMN) consist of a heterogeneous spectrum of peripheral nerve disorders. Although IMN is associated with several hematological disorders, it remains a very rare complication of hematopoietic stem cell transplantation (HCT). We describe our experiences of 3 patients with multiple myeloma who experienced IMN following autologous HCT (auto-HCT)...
January 17, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28087457/t-cell-replete-peripheral-blood-haploidentical-hematopoietic-cell-transplantation-with-post-transplant-cyclophosphamide-results-in-outcomes-similar-to-traditionally-matched-donors-in-active-disease-acute-myeloid-leukemia
#2
Joan How, Michael Slade, Khoan Vu, John F DiPersio, Peter Westervelt, Geoffrey L Uy, Camille N Abboud, Ravi Vij, Mark A Schroeder, Todd A Fehniger, Rizwan Romee
Outcomes for acute myeloid leukemia (AML) patients who fail to achieve complete remission remain poor. Hematopoietic cell transplantation (HCT) has been shown to induce long-term survival in AML patients with active disease. HCT is largely performed with HLA-matched unrelated or HLA-matched related donors. Recently, HCT with HLA-haploidentical related donors has been identified as a feasible option when HLA-matched donors are not immediately available. However, there is little data comparing outcomes of AML patients with active disease who receive haploidentical versus traditionally matched HCT...
January 10, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28067881/single-institution-experience-with-g-csf-mobilized-t-cell-replete-haploidentical-hematopoietic-cell-transplantation
#3
E Huselton, M Slade, J F DiPersio, P Westervelt, R Vij, G L Uy, T A Fehniger, C N Abboud, F Gao, M A Schroeder, R Romee
No abstract text is available yet for this article.
January 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28045510/anaerobic-heme-degradation-chuy-is-an-anaerobilin-reductase-that-exhibits-kinetic-cooperativity
#4
Joseph W LaMattina, Michael Anthony Delrossi, Katherine Grace Uy, Nicholas D Keul, David B Nix, William Nicholas Lanzilotta
Heme catabolism is an important biochemical process that many bacterial pathogens utilize to acquire iron. However, tetrapyrrole catabolites can be reactive and often require further processing in order for safe transport out of the cell or conversion to another useful cofactor. In previous work, we presented in vitro evidence for an anaerobic heme degradation pathway in Escherichia coli O157:H7. Consistent with reactions that have been reported for other radical SAM methyltransferases, ChuW transfers a methyl group to heme by a radical mediated mechanism and catalyzes the -scission of porphyrin macrocycle...
January 3, 2017: Biochemistry
https://www.readbyqxmd.com/read/28044381/the-romhilt-estes-electrocardiographic-score-predicts-sudden-cardiac-arrest-independent-of-left-ventricular-mass-and-ejection-fraction
#5
Navid Darouian, Aapo L Aro, Kumar Narayanan, Audrey Uy-Evanado, Carmen Rusinaru, Kyndaron Reinier, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: The Romhilt-Estes point score system (RE) is an established ECG criterion for diagnosing left ventricular hypertrophy (LVH). In this study, we assessed for the first time, whether RE and its components are predictive of sudden cardiac arrest (SCA) independent of left ventricular (LV) mass. METHODS: Sudden cardiac arrest (SCA) cases occurring between 2002 and 2014 in a Northwestern US metro region (catchment area approx. 1 million) were compared to geographic controls...
January 3, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28030755/epidemiology-of-infections-following-haploidentical-peripheral-blood-hematopoietic-cell-transplantation
#6
Michael Slade, Scott Goldsmith, Rizwan Romee, John F DiPersio, Erik R Dubberke, Peter Westervelt, Geoffrey L Uy, Steven J Lawrence
BACKGROUND: The use of T-cell replete haploidentical hematopoietic cell transplant (haplo-HCT) has increased substantially since the introduction of post-transplant cyclophosphamide (PTCy) regimens. Limited data exist concerning infectious complications of haplo-HCT utilizing mobilized peripheral blood (PB) hematopoietic cells. METHODS: This retrospective cohort study included all adult patients at our institution undergoing PB haplo-HCT with PTCy between June 2009 and June 2015...
November 7, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28012047/the-protective-mechanism-of-qgc-in-feline-esophageal-epithelial-cells-by-interleukin-1%C3%AE-treatment
#7
Hyun Soo Jang, Seung In Um, Sung Hee Lee, Wan Kyunn Whang, Young Sil Min, Sun Young Park, Uy Dong Sohn
In a previous study, Quercetin-3-O-β-D-glucuronopyranoside (QGC) has anti-oxidative and anti-inflammatory effects in vivo. QGC is a flavonoid glucoside extracted from Rumex Aquaticus. We investigated the downstream target proteins involved in IL-1β-stimulated ROS production and the ability of QGC to inhibit ROS production. Cell viability was determined using the MTT reduction assay. Western blot analysis was performed with antibodies to investigate the activation of three MAPKs, NF-κB, and phosphorylated IκB-α (pIB), and the expression of COX-2...
December 23, 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27991501/the-immunohistochemical-and-urodynamic-evaluation-towards-the-collagen-coated-and-non-coated-polypropylene-meshes-implanted-in-the-pelvic-wall-of-the-rats
#8
Tsia-Shu Lo, Yi-Hao Lin, Faridah Mohd Yusoff, Hsiao-Chien Chu, Wu-Chiao Hsieh, Ma Clarissa Uy-Patrimonio
Our aim is to study the inflammatory response towards the collagen-coated and non-coated polypropylene meshes in rats and the urodynamic investigation post-operatively. Forty-two female Sprague Dawley were divided into 7 groups of 6 rats; Control, Day 7 and 30 for Sham, Avaulta Plus (MPC), Perigee (MP). UDS were taken at days 7 and 30. Mesh with the vagina and bladder wall was removed and sent for immunohistochemical examination. Results showed intense inflammatory reaction on day 7 in the study groups which decreased on day 30...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27988060/syncope-and-risk-of-sudden-cardiac-arrest-in-coronary-artery-disease
#9
Aapo L Aro, Carmen Rusinaru, Audrey Uy-Evanado, Kyndaron Reinier, Derek Phan, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: Syncope has been associated with increased risk of sudden cardiac arrest (SCA) in specific patient populations, such as hypertrophic cardiomyopathy, heart failure, and long QT syndrome, but data are lacking on the risk of SCA associated with syncope among patients with coronary artery disease (CAD), the most common cause of SCA. We investigated this association among CAD patients in the community. METHODS: All cases of SCA due to CAD were prospectively identified in Portland, Oregon (population approximately 1 million) as part of the Oregon Sudden Unexpected Death Study 2002-2015, and compared to geographical controls...
December 12, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27986636/sleep-duration-moderates-the-association-between-insula-activation-and-risky-decisions-under-stress-in-adolescents-and-adults
#10
Jessica Phuong Uy, Adriana Galván
Insufficient sleep has been associated with increased risk-taking and poor decision-making, enhanced physiological responses to stress, and attenuated anterior insula (AI) activity to risk. The AI has also been linked to risky decision-making under acute stress. However, it is yet unknown how naturalistic sleep habits affect risky decision-making and AI activity when individuals feel stressed. In the current study, a daily diary approach was used to document participants' daily stress. Adolescents and adults reported their recent sleep duration and completed two fMRI visits during which they performed a risky decision-making task: once each when they endorsed a high and low level of stress...
December 13, 2016: Neuropsychologia
https://www.readbyqxmd.com/read/27972824/developing-a-comprehensive-culturally-sensitive-conceptual-framework-of-health-domains-in-singapore
#11
E J Uy, M Y Ow, X Xin, S C Sung, Y B Cheung, D Bautista, J Thumboo
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27972819/developing-item-pools-for-physical-functioning-social-relationships-and-positive-mindset-to-measure-health-related-quality-of-life-hrqol-in-the-singapore-population
#12
E J Uy, Y Xiao, P T Yeo, X Xin, Y Pua, G L Lee, Y H Kwan, J A Vaingankar, M Subramaniam, M F Chan, N Kumar, D Bautista, M Y Ow, P A Lim, B E Choo, Y Y Leung, A Chan, S C Sung, T C Kwek, Y B Cheung, J Thumboo
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27972813/using-best-worst-scaling-choice-experiments-to-elicit-the-most-important-domains-of-health-related-quality-of-life-hrqol-in-singapore
#13
E J Uy, D Bautista, X Xin, Y B Cheung, S Thio, J Thumboo
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27959731/tp53-and-decitabine-in-acute-myeloid-leukemia-and-myelodysplastic-syndromes
#14
John S Welch, Allegra A Petti, Christopher A Miller, Catrina C Fronick, Michelle O'Laughlin, Robert S Fulton, Richard K Wilson, Jack D Baty, Eric J Duncavage, Bevan Tandon, Yi-Shan Lee, Lukas D Wartman, Geoffrey L Uy, Armin Ghobadi, Michael H Tomasson, Iskra Pusic, Rizwan Romee, Todd A Fehniger, Keith E Stockerl-Goldstein, Ravi Vij, Stephen T Oh, Camille N Abboud, Amanda F Cashen, Mark A Schroeder, Meagan A Jacoby, Sharon E Heath, Kierstin Luber, Megan R Janke, Andrew Hantel, Niloufer Khan, Madina J Sukhanova, Randall W Knoebel, Wendy Stock, Timothy A Graubert, Matthew J Walter, Peter Westervelt, Daniel C Link, John F DiPersio, Timothy J Ley
Background The molecular determinants of clinical responses to decitabine therapy in patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) are unclear. Methods We enrolled 84 adult patients with AML or MDS in a single-institution trial of decitabine to identify somatic mutations and their relationships to clinical responses. Decitabine was administered at a dose of 20 mg per square meter of body-surface area per day for 10 consecutive days in monthly cycles. We performed enhanced exome or gene-panel sequencing in 67 of these patients and serial sequencing at multiple time points to evaluate patterns of mutation clearance in 54 patients...
November 24, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27930286/left-ventricular-geometry-and-risk-of-sudden-cardiac-arrest-in-patients-with-severely-reduced-ejection-fraction
#15
Derek Phan, Aapo L Aro, Kyndaron Reinier, Carmen Teodorescu, Audrey Uy-Evanado, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: Recent reports indicate that specific left ventricular (LV) geometric patterns predict recurrent ventricular arrhythmias in patients with implantable cardioverter-defibrillators and reduced left ventricular ejection fraction (LVEF). However, this relationship has not been evaluated among patients at risk of sudden cardiac arrest (SCA) in the general population. METHODS AND RESULTS: Adult SCA cases from the Oregon Sudden Unexpected Death Study were compared with geographic controls with no prior history of SCA...
August 18, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27927655/role-of-cannabinoid-receptor-type-1-in-tibial-and-pudendal-neuromodulation-of-bladder-overactivity-in-cats
#16
Xuewen Jiang, Michelle Yu, Jamie Uy, Thomas Fuller, Cameron Jones, Bing Shen, Jicheng Wang, James R Roppolo, William de Groat, Changfeng Tai
The role of cannabinoid type 1 (CB1) receptors in tibial and pudendal neuromodulation of bladder overactivity induced by intravesical infusion of 0.5% acetic acid (AA) was determined in α-chloralose anesthetized cats. AA irritation significantly (p<0.01) reduced bladder capacity to 36.6±4.8% of saline control capacity. Tibial nerve stimulation (TNS) at 2 or 4 times threshold (T) intensity for inducing toe movement inhibited bladder overactivity and significantly (p<0.01) increased bladder capacity to 69...
December 7, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27904808/effect-of-common-and-experimental-anti-tuberculosis-treatments-on-mycobacterium-tuberculosis-growing-as-biofilms
#17
James P Dalton, Benedict Uy, Narisa Phummarin, Brent R Copp, William A Denny, Simon Swift, Siouxsie Wiles
Much is known regarding the antibiotic susceptibility of planktonic cultures of Mycobacterium tuberculosis, the bacterium responsible for the lung disease tuberculosis (TB). As planktonically-grown M. tuberculosis are unlikely to be entirely representative of the bacterium during infection, we set out to determine how effective a range of anti-mycobacterial treatments were against M. tuberculosis growing as a biofilm, a bacterial phenotype known to be more resistant to antibiotic treatment. Light levels from bioluminescently-labelled M...
2016: PeerJ
https://www.readbyqxmd.com/read/27895044/polymorphisms-in-the-gnas-gene-as-predictors-of-ventricular-tachyarrhythmias-and-sudden-cardiac-death-results-from-the-discovery-trial-and-oregon-sudden-unexpected-death-study
#18
Heinrich Wieneke, Jesper Hastrup Svendsen, Jeffrey Lande, Sebastian Spencker, Juan Gabriel Martinez, Bernhard Strohmer, Lauri Toivonen, Hervé Le Marec, F Javier Garcia-Fernandez, Domenico Corrado, Adriana Huertas-Vazquez, Audrey Uy-Evanado, Carmen Rusinaru, Kyndaron Reinier, Csaba Foldesi, Wieslaw Hulak, Sumeet S Chugh, Winfried Siffert
BACKGROUND: Population-based studies suggest that genetic factors contribute to sudden cardiac death (SCD). METHODS AND RESULTS: In the first part of the present study (Diagnostic Data Influence on Disease Management and Relation of Genetic Polymorphisms to Ventricular Tachy-arrhythmia in ICD Patients [DISCOVERY] trial) Cox regression was done to determine if 7 single-nucleotide polymorphisms (SNPs) in 3 genes coding G-protein subunits (GNB3, GNAQ, GNAS) were associated with ventricular tachyarrhythmia (VT) in 1145 patients receiving an implantable cardioverter-defibrillator (ICD)...
November 28, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27885462/the-cytoprotective-effect-of-rumex-aquaticus-herba-extract-against-hydrogen-peroxide-induced-oxidative-stress-in-ags-cells
#19
Eun Jeong Cho, Seung In Um, Jeong Hoon Han, Byeonghee Kim, Sang Beom Han, Ji Hoon Jeong, Hak Rim Kim, Inkyeom Kim, Wan Kyun Whang, Eunhwa Lee, Uy Dong Sohn
The Rumex Aquaticus Herba extract containing quercetin-3-β-D-glucuronopyranoside (ECQ) has been reported to exhibit various pharmacological activities, including anti-inflammatory and anti-oxidative effects. This plant has been traditionally used for the treatment of diarrhea, disinfestation, edema and jaundice, and as an antipyretic drug. The aim of the present study was to investigate the ability of ECQ to protect against oxidative damage and to determine its signaling mechanism in AGS cells. The protein expressions of heme oxygenase-1 (HO-1) and nuclear factor-erythroid 2 related factor 2 (Nrf2) were measured by Western blots...
December 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27856388/bilateral-salpingectomy-utilizing-percutaneous-mini-laparoscopy
#20
Cynthia Arvizo, M Jean Uy-Kroh
STUDY OBJECTIVE: To demonstrate a new for bilateral salpingectomy utilizing percutaneous mini-laparoscopy. DESIGN: Step-by-step video demonstration and narration of the surgical procedure SETTING: Mini-laparoscopy was first described in the late 1980s and early 1990s. Since then, mini-laparoscopic instruments have been successfully applied to several general surgery and gynecologic procedures, including hysterectomy. Potential benefits of mini-laparoscopy compared to conventional laparoscopy include decreased tissue trauma, pain, and improved cosmesis...
November 14, 2016: Journal of Minimally Invasive Gynecology
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