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https://www.readbyqxmd.com/read/29785081/pressurized-intraperitoneal-aerosol-chemotheprapy-after-misdiagnosed-gastric-cancer-case-report-and-review-of-the-literature
#1
Maciej Nowacki, Dariusz Grzanka, Wojciech Zegarski
We report the first application of pressurized intraperitoneal aerosol chemotherapy (PIPAC) as a rescue therapy before palliative D2 gastrectomy combined with liver metastasectomy performed in a 49-year-old woman with peritoneal carcinomatosis who was primarily diagnosed with and underwent surgery for a Krukenberg tumor. The PIPAC procedure was performed with the use of cisplatin at 7.5 mg/m2 and doxorubicin at 1.5 mg/m2 for 30 min at 37 °C. Eight weeks after the PIPAC procedure, the patient underwent open classic D2 gastrectomy with the creation of a Roux-en-Y anastomosis (RNY) combined with liver metastasectomy...
May 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29743140/a-phase-i-single-arm-open-label-dose-escalation-study-of-intraperitoneal-cisplatin-and-doxorubicin-in-patients-with-recurrent-ovarian-cancer-and-peritoneal-carcinomatosis
#2
Clemens B Tempfer, Urs Giger-Pabst, Veronika Seebacher, Miriam Petersen, Askin Dogan, Günther A Rezniczek
OBJECTIVE: We performed a phase I, single-arm, non-randomized, open-label, dose-escalation trial to determine the dose-limiting toxicity of intraperitoneal cisplatin and doxorubicin applied as pressurized intraperitoneal aerosol chemotherapy (PIPAC) in women with recurrent ovarian cancer. METHODS: We used a standard 3 + 3 dose-escalation design with doxorubicin 1.5 mg/m2 , cisplatin 7.5 mg/m2 q 4 to 6 weeks for 3 cycles and subsequent dose escalation steps (20% increment per step) in patients with recurrent ovarian cancer and peritoneal carcinomatosis...
May 6, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29740404/inhalational-gentamicin-treatment-is-effective-against-pneumonic-plague-in-a-mouse-model
#3
David Gur, Itai Glinert, Moshe Aftalion, Yaron Vagima, Yinon Levy, Shahar Rotem, Ayelet Zauberman, Avital Tidhar, Arnon Tal, Sharon Maoz, Raphael Ber, Avi Pass, Emanuelle Mamroud
Pneumonic plague is an infectious disease characterized by rapid and fulminant development of acute pneumonia and septicemia that results in death within days of exposure. The causative agent of pneumonic plague, Yersinia pestis (Y. pestis) , is a Tier-1 bio-threat agent. Parenteral antibiotic treatment is effective when given within a narrow therapeutic window after symptom onset. However, the non-specific "flu-like" symptoms often lead to delayed diagnosis and therapy. In this study, we evaluated inhalational gentamicin therapy in an infected mouse model as a means to improve antibiotic treatment efficacy...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29733972/application-of-an-inline-dry-powder-inhaler-to-deliver-high-dose-pharmaceutical-aerosols-during-low-flow-nasal-cannula-therapy
#4
Dale Farkas, Michael Hindle, P Worth Longest
Inline dry powder inhalers (DPIs) offer a potentially effective option to deliver high dose inhaled medications simultaneously with mechanical ventilation. The objective of this study was to develop an inline DPI that is actuated using a low volume of air (LV-DPI) to efficiently deliver pharmaceutical aerosols during low flow nasal cannula (LFNC) therapy. A characteristic feature of the new inline LV-DPIs was the use of hollow capillary tubes that both pierced the capsule and provided a pathway for inlet air and exiting aerosol...
May 5, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29731374/-inhaled-chemotherapy-part-2-clinical-practice-and-potential-applications
#5
REVIEW
R Rosière, J Hureaux, V Levet, K Amighi, N Wauthoz
Lung tumours have a high incidence and cause many deaths worldwide. Despite progresses in treatment with targeted therapies and immunotherapies, the global 5-year survival rate remains low. In this context, inhaled chemotherapy could provide a means to intensify current therapeutic modalities. This review is based on clinical studies of inhaled chemotherapy against lung tumours. The advantages of this approach in terms of pharmacokinetic ratio and therapeutic index are presented as well as the limitations including contraindications and pulmonary side effects...
May 3, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29724399/treatment-compliance-in-cystic-fibrosis-patients-with-chronic-pseudomonas-aeruginosa-infection-treated-with-tobramycin-inhalation-powder-the-free-study
#6
Francesco Blasi, Vincenzo Carnovale, Giuseppe Cimino, Vincenzina Lucidi, Donatello Salvatore, Barbara Messore, Marta Bartezaghi, Elisa Muscianisi, Pasquale Alberto Porpiglia
BACKGROUND: A high treatment burden with nebulised therapies in cystic fibrosis (CF) patients is the major limitation for treatment compliance; moreover, studies on treatment compliance with inhaled antibiotics are limited. This study assessed compliance to TOBI® Podhaler™ (TIP) treatment in CF patients with chronic Pseudomonas aeruginosa (Pa) infections in a real-world setting using the Italian Treatment Adherence CF Questionnaire (ITA-CFq). METHODS: This longitudinal, multicentre, cohort study included 2 follow-up (FU) visits: FU-1 at 3-months±15-days from the baseline visit and FU-2 at the end of third TIP cycle (or 6-months after enrolment, whichever occurred first)...
May 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29716819/a-randomized-trial-comparing-metered-dose-inhalers-and-breath-actuated-nebulizers
#7
Mark A Snider, Jim Y Wan, Jonathan Jacobs, Rudy Kink, Barry Gilmore, Sandra R Arnold
BACKGROUND: Despite little evidence for its effectiveness, the breath-actuated nebulizer (BAN) is the default albuterol delivery method in our pediatric emergency department. OBJECTIVE: We compared the clinical efficacy of BAN and the metered-dose inhaler (MDI) in treating subjects patients 2 to 17 years of age who presented with mild to moderate asthma exacerbations. METHODS: This is a randomized, nonblinded, noninferiority study conducted at a single pediatric tertiary care emergency department...
April 28, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29705882/severe-peritoneal-sclerosis-after-repeated-pressurized-intraperitoneal-aerosol-chemotherapy-with-oxaliplatin-pipac-ox-report-of-two-cases-and-literature-survey
#8
M Graversen, S Detlefsen, P Pfeiffer, L Lundell, M B Mortensen
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new laparoscopic administration of chemotherapy for peritoneal metastasis (PM). PIPAC is repeated every 5th week, and seems to stabilize or improve quality of life, and might improve survival. So far, PIPAC has been well tolerated. With this paper, we aim to highlight a potential severe adverse reaction, as we describe the first cases of severe peritoneal sclerosis (SPS) caused by PIPAC. Patients with isolated PM were included in a prospective PIPAC protocol...
April 28, 2018: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/29679678/characterisation-of-40-mg-ml-and-100-mg-ml-tobramycin-formulations-for-aerosol-therapy-with-adult-mechanical-ventilation
#9
Jayesh A Dhanani, Patrician Tang, Steven C Wallis, Suzanne L Parker, Preeti Pandey, John F Fraser, Jeremy Cohen, Adrian Barnett, Jason R Roberts, Hak-Kim Chan
BACKGROUND: Preservative-free tobramycin is commonly used as aerosolized therapy for ventilator associated pneumonia. The comparative delivery profile of the formulations of two different concentrations (100 mg/ml and 40 mg/ml) is unknown. This study aims to evaluate the aerosol characteristics of these tobramycin formulations in a simulated adult mechanical ventilation model. METHODS: Simulated adult mechanical ventilation set up and optimal settings were used in the study...
April 18, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29610563/aerosol-gemcitabine-after-amputation-inhibits-osteosarcoma-lung-metastases-but-not-wound-healing
#10
Eugenie S Kleinerman, Ling Yu, Jasmine Dao, Andrea A Hayes-Jordan, Brock Lindsey, Jitesh D Kawedia, John Stewart, Nancy Gordon
Background: In newly diagnosed osteosarcoma (OS) patients, the time between surgery and resumption of chemotherapy is 2-7 weeks. Delays > 16 days are associated with increased risk of relapse and decreased overall survival. Identifying an effective therapy that can be used postoperatively may prevent relapse. We investigated whether aerosol gemcitabine (GCB) initiated after tumor resection inhibited the growth of OS lung metastases without affecting the wound-healing process. Methods: Mice were injected intratibially with OS cells...
2018: Sarcoma
https://www.readbyqxmd.com/read/29599187/the-in-vitro-effect-of-nebulised-hypertonic-saline-on-human-bronchial-epithelium
#11
Jennifer L Goralski, Dan Wu, William R Thelin, Richard C Boucher, Brian Button
RATIONALE: Inhaled hypertonic saline (HS) is an effective therapy for muco-obstructive lung diseases. However, the mechanism of action and principles pertinent to HS administration remain unclear. METHODS: An in vitro system aerosolized HS to epithelial cells at rates comparable to in vivo conditions. Airway surface liquid (ASL) volume and cell height responses were measured by confocal microscopy under normal and hyperconcentrated mucus states. MAIN RESULTS: Aerosolized HS produced a rapid increase in ASL height and decrease in cell height...
March 29, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29593708/mucosal-delivery-of-fusion-proteins-with-bacillus-subtilis-spores-enhances-protection-against-tuberculosis-by-bacillus-calmette-gu%C3%A3-rin
#12
Alastair Copland, Gil R Diogo, Peter Hart, Shane Harris, Andy C Tran, Mathew J Paul, Mahavir Singh, Simon M Cutting, Rajko Reljic
Tuberculosis (TB) is the most deadly infectious disease in existence, and the only available vaccine, Bacillus Calmette-Guérin (BCG), is almost a century old and poorly protective. The immunological complexity of TB, coupled with rising resistance to antimicrobial therapies, necessitates a pipeline of diverse novel vaccines. Here, we show that Bacillus subtilis spores can be coated with a fusion protein 1 ("FP1") consisting of Mycobacterium tuberculosis (Mtb) antigens Ag85B, ACR, and HBHA. The resultant vaccine, Spore-FP1, was tested in a murine low-dose Mtb aerosol challenge model...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29581792/inhaled-immunotherapy-administration-for-lung-cancer-efficient-certainly-possible
#13
Konstantinos Sapalidis, Paul Zarogoulidis, Haidong Huang, Chong Bai, Yuting Wen, Li Wang, Konstantina Boniou, Ilias Karapantzos, Chrysanthi Karapantzou, Michael Karanikas, Vasilis Thomaidis, Christoforos Kosmidis, Chrysanthi Sardeli, Naim Benhassen, Yan-Gao Man, Maria C Florou, Stylianos Mantalovas, Stella Laskou, Dimitris Giannakidis, Charilaos Koulouris, Aikaterini Amaniti, Isaak Kesisoglou, Wolfgang Hohenforst-Schmidt
Lung cancer is still diagnosed at a late stage in most lung cancer patients. Regarding Non-small Cell lung cancer there are novel therapies such as; tyrosine kinase inhibitors and immunotherapy. Currently we have two immunotherapies that can be used either as first-line treatment or second line treatment; pembrolizumab and nivolumab. A third one is being investigated as a combination of immunotherapy; ipilimumab. Aerosol treatment has been investigated for many diseases not only for the lung, but also for systematic diseases...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29559772/knowledge-and-pharmaceutical-care-practice-regarding-inhaled-therapy-among-registered-and-unregistered-pharmacists-an-urgent-need-for-a-patient-oriented-health-care-educational-program-in-iraq
#14
Shaymaa Abdalwahed Abdulameer
Background: Inadequate inhaled aerosol device demonstration and technique by health care professionals can lead to poor disease control. The aims of this study were to develop and validate Knowledge of Aerosol Tool (KAT) among registered and unregistered pharmacists and to assess the pharmaceutical care practice among registered pharmacists. Methods: The KAT and pharmaceutical care practice questionnaires were developed and modified from previous reports, then an observational cross-sectional study with a convenience sample size of 340 was carried out among registered and unregistered pharmacists...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29550803/in-vivo-and-in-vitro-studies-on-multidirectional-mechanism-of-anti-allergic-activity-of-budesonide
#15
E Trybus, G Krol, T Obarzanowski, W Trybus, A Kopacz-Bednarska, M Obarzanowski, T Krol
Most studies on the effects of glucocorticosteroid therapy in rhinitis relate to their inhibitory effect on activation and the number of inflowing cells that are involved in the development and maintenance of inflammation. It is also very important to determine the range of effect of budesonide on residing cells (epithelial cells). The purpose of this study was to evaluate the effect of local budesonide therapy on the cytological image of the nasal mucosa, with attention paid to columnar cells in patients with rhinitis...
December 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29535260/high-flow-nasal-cannula-in-pediatric-patients-a-survey-of-clinical-practice
#16
Andrew G Miller, Michael A Gentle, Lisa M Tyler, Natalie Napolitano
BACKGROUND: High-flow nasal cannula (HFNC) use has greatly increased in recent years. In non-neonatal pediatric patients, there are limited data available to guide HFNC use, and clinical practice may vary significantly. The goal of this study was to evaluate current HFNC practice by surveying practicing pediatric respiratory therapists. METHODS: A survey instrument was posted on the American Association for Respiratory Care's AARConnect online social media platform in March 2017...
March 13, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29527305/influenza-and-influenza-like-syndromes-the-subjects-beliefs-the-attitude-to-prevention-and-treatment-and-the-impact-in-italian-general-population
#17
Roberto W Dal Negro, Alessandro Zanasi, Paola Turco, Massimiliano Povero
Background: Influenza and influenza-like syndromes (I-LSs) are infectious diseases occurring on a seasonal basis which can lead to upper (URTI) and lower respiratory tract illness (LRTI) of different severity. The approach to these disorders is unfortunately not uniform. Aim of the study was to investigate real-life people beliefs, the attitude to their prevention and treatment, and their impact in general population. Methods: A cross-sectional survey via Computer Assisted Telephone Interview (CATI) was carried out using a specific questionnaire investigating influenza episode rates, subjects behavior in case of influenza and I-LSs, and prescribed therapy...
2018: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/29512367/effects-of-connexin-43-inhibition-in-an-ovalbumin-induced-mouse-model-of-asthma
#18
Jian-Qiang Huang, Xiao-Yang Chen, Fang Huang, Ji-Min Fan, Xiao-Wei Shi, Yan-Kai Ju
Connexion 43 (Cx43), a gap junction protein, is expressed abundantly in the airway and has been implicated in the pathogenesis of asthma. However, the effects of blocking Cx43 in asthma remain unclear. We investigated the therapeutic effects of two specific Cx43 inhibitors (Gap26 and Gap27) on the development of allergic airway disease in mice. Allergic asthma was induced in BALB/c mice by sensitization and challenge with ovalbumin (OVA). Different doses of Cx43 inhibitors were administered by aerosol inhalation 1 h after OVA challenge on days 21 and 23...
February 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29499614/use-of-functional-respiratory-imaging-to-characterize-the-effect-of-inhalation-profile-and-particle-size-on-lung-deposition-of-inhaled-corticosteroid-long-acting-%C3%AE-2-agonists-delivered-via-a-pressurized-metered-dose-inhaler
#19
Cedric Van Holsbeke, Jan De Backer, Wim Vos, Jonathan Marshall
BACKGROUND: Functional respiratory imaging (FRI) uses three-dimensional models of human lungs and computational fluid dynamics to simulate functional changes within airways and predict the deposition of inhaled drugs. This study used FRI to model the effects of different patient inhalation and drug formulation factors on lung deposition of an inhaled corticosteroid/long-acting β2 -agonist (ICS/LABA) combination, administered by a pressurized metered-dose inhaler. METHODS: Three-dimensional models of the lungs of six patients with asthma (mean forced expiratory volume in 1 s, 83%), treated with an ICS/LABA, were included...
January 2018: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/29461896/chronic-obstructive-pulmonary-disease-a-biomarker-and-a-potential-therapy
#20
Gerard M Turino
This article assesses developments in cardiorespiratory medicine since the Nobel Prize in Physiology or Medicine was awarded in 1956 for advancements in the study of cardiorespiratory disease. In chronic obstructive pulmonary disease, advances were accelerated by the discovery of a genetically determined cause for pulmonary emphysema in the genetic abnormality alpha-1 antitrypsin deficiency. This causes a deficiency of the inhibitor of neutrophil elastase, which results in increased degradation of lung elastin and the development of pulmonary emphysema...
February 2018: Annals of the American Thoracic Society
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