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Colchicum

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https://www.readbyqxmd.com/read/29762881/colchicine-a-microtubule-disassembling-drug-in-the-therapy-of-cardiovascular-diseases
#1
George N Chaldakov
Colchicum autumnale, from which colchicine has been isolated more than 100 years ago, has been used as a treatment for pain and swelling for thousands of years. It is one of the few drugs known from that time period whose use has survived to modernity. Over the past decades, advances in the knowledge of (i) cytoskeletal microtubules (МТ), and (ii) anti-inflammatory and anti-fibrotic effects of colchicine, a classical MT-disassembling (tubulin-targeting) agent, have led to potential new uses for this very old drug extended beyond acute gouty arthritis and familial Mediterranean fever...
May 15, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29359661/colchicine-pharmacokinetics-and-mechanism-of-action
#2
Christos Angelidis, Zoi Kotsialou, Charalampos Kossyvakis, Agathi-Rosa Vrettou, Achilleas Zacharoulis, Fotios Kolokathis, Vasilios Kekeris, Georgios Giannopoulos
Colchicine is a tricyclic, lipid-soluble alkaloid derived from the plant of the Lily family Colchicum autumnale, sometimes called the "autumn crocus". It is predominantly metabolized in the gastrointestinal tract. Two proteins, P-glycoprotein (P-gp) and CYP3A4 seem to play a pivotal role, governing its pharmacokinetic. The commonest side effects are gastrointestinal (nausea, vomiting and particularly dose-related-diarrhea) occurring in 5-10% of patients. Colchicine exerts its unique action mainly through inhibition of microtubule polymerization...
January 22, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29336251/isolating-colchicine-in-19th-century-an-old-drug-revisited
#3
Marianna Karamanou, Gregory Tsoucalas, Konstantinos Pantos, George Androutsos
Colchicine is a tricyclic alkaloid extracted from the herbaceous plant Colchicum autumnale. Known since antiquity for its therapeutic efficacy in the treatment of gout, colchicine was reintroduced in 19th century pharmacopeia, thanks to the work of the French chemists and pharmacists Pierre-Joseph Pelletier (1788-1842) and Joseph Bienaime Caventou (1795-1877) who in 1819, isolated a peculiar substance in the roots of Colchicum autumnale. In 1833, the substance was further analyzed by the German pharmacist and chemist Philipp Lorenz Geiger (1785-1836), who coined the name colchicine...
January 14, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29336250/colchicum-genus-in-the-writings-of-ancient-greek-and-byzantine-physicians
#4
Gregory Tsoucalas, Theodoros Papaioannou, George Panayiotakopoulos, Zenia Saridaki, Dimitrios A Vrachatis, Marianna Karamanou
The plants of the Colchicum family were known during the archaic period in Greece for their deleterious properties. Later on, they were used for the treatment of podagra. The treatment was introduced by the ancient Greek physicians and passed on to the Byzantine and Arabian physicians to endure until nowadays. The first plant was most probably named "Medea" from the notorious Colchican witch. As the most common member of the family blossoms in autumn, the plant was named Colchicum autumnale. Various nominations were also used, such as Ephemeron, Hermodactyl, Anima articulorum and Surugen...
January 14, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29046164/colchicine-a-review-about-chemical-structure-and-clinical-using
#5
Hourieh Alkadi, Mohamad Jowad Khubeiz, Rajwa Jbeily
For many years, colchicine has been used for therapeutic purposes and has been given considerable attention because of its association with tubulin and inhibition of small tubular polymerization. Colchicine is an alkaloids extracted from the colchicum autumnale plant, and it contains a molecular formula C22H25NO6, and it consists of three rings. Many studies have concerned with structural changes, in order to increase their pharmacological effectiveness and to reduce the side effects of toxicity arising from it...
October 17, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28975371/bithiophenic-maldi-matrices-as-valuable-leads-for-the-selective-detection-of-alkaloids
#6
Ali Jaber, Denis Seraphin, David Guilet, Junichi Osuga, Edmond Cheble, Ghassan Ibrahim, Pascal Richomme, Andreas Schinkovitz
Alkaloids represent a group of biologically most interesting compounds commonly used in modern medicines but also known for exhibiting severe toxic effects. Therefore, the detection of alkaloids is an important issue in quality control of plants, dietary supplements, and herbal pharmaceutical and mostly facilitated by methods such as GC or LC-MS. However, benefitting from the development of selective matrices as well as requiring very little sample preparation, MALDI-MS may also provide a valuable supplement to these standard analytical methods...
November 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28767055/modeling-the-colchicum-autumnale-tubulin-and-a-comparison-of-its-interaction-with-colchicine-to-human-tubulin
#7
Ivana Spasevska, Ahmed T Ayoub, Philip Winter, Jordane Preto, Gane K-S Wong, Charles Dumontet, Jack A Tuszynski
Tubulin is the target for many small-molecule natural compounds, which alter microtubules dynamics, and lead to cell cycle arrest and apoptosis. One of these compounds is colchicine, a plant alkaloid produced by Colchicum autumnale. While C. autumnale produces a potent cytotoxin, colchicine, and expresses its target protein, it is immune to colchicine's cytotoxic action and the mechanism of this resistance is hitherto unknown. In the present paper, the molecular mechanisms responsible for colchicine resistance in C...
August 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28684450/reversible-granulocyte-abnormalities-after-accidental-ingestion-of-colchicum-autumnale
#8
Antonios Kritikos, Olivier Spertini
No abstract text is available yet for this article.
July 6, 2017: Blood
https://www.readbyqxmd.com/read/28058497/-a-rare-cause-of-severe-panniculitis
#9
C Fiehn
A 58-year-old patient presented with a severe, episodic panniculitis of the upper legs. Necrosis of the fatty tissue and a suspected superinfection led to amputation of one leg. The panniculitis was caused by a hereditary deficiency of alpha-1 antitrypsin (AAT) due to a ZZ mutation of the AAT gene. Neutrophilic panniculitis is found in 0.1% of patients with the ZZ mutation and therefore is the rarest clinical manifestation of AAT deficiency. With the exception of mild COPD, the patient had no other typical clinical symptoms of AAT deficiency...
March 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28039722/screening-for-antitumor-activity-of-various-plant-extracts-on-hela-and-c-4-i-cell-lines
#10
COMPARATIVE STUDY
Gul Ozcan, Ozlem Dagdeviren Ozsoylemez, Gizem Akman, Walid Khalilia, Beliz Tezel Yetiz, Ali Karagoz, Gulay Melikoglu, Sezin Anil, Sukran Kultur, Nurhayat Sutlupinar
PURPOSE: Cancer is a long process that leads the organism to death and is associated with the normal cells acquiring the ability to divide permanently. Nowadays, the use of natural products in cancer therapy has a great importance. In addition, working with plants that are endemic to Turkey and determining the biological activities of these plant extracts, is extremely important due to the potential for new drug development. There is no comparative study available in the literature on the antitumor effects of Colchicum sanguicolle, a new found species of the genus Colchicum in Turkey, Crateagus microphylla, of the genus Crateagus and Centaurea antiochia of the genus Centaurea...
November 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28030380/potential-anticancer-role-of-colchicine-based-derivatives-an-overview
#11
REVIEW
Ashok Kumar, Parduman R Sharma, Dilip M Mondhe
Colchicine, the main alkaloid of the poisonous plant meadow saffron (Colchicum autumnale L.), is a classical drug used for the treatment of gout and familial Mediterranean fever. Although colchicine is not clinically used to treat cancer because of toxicity, it exerts antiproliferative effects through the inhibition of microtubule formation by blocking the cell cycle at the G2/M phase and triggering apoptosis. Colchicine can still be used as a lead compound for the generation of potential anticancer drugs. Thus, numerous analogues of colchicine have been synthesized in the hope of developing novel, useful drugs with more favourable pharmacological profiles...
March 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/27834133/the-effects-of-colchicum-baytopiorum-on-regulatory-genes-of-apoptotic-and-autophagic-cell-death-in-hela-cells
#12
Ozlem D Ozsoylemez, Melek Ozturk, Nurhayat Sutlupinar, Sera Kayacan, Matem Tuncdemir, Gul Ozan
BACKGROUND: The natural products have increasing important for the development of anticancer agents. Colchicum baytopiorum C.D. Brickell (C. baytopiorum), an endemic species for Turkey, contains colchicine and its derivatives. Stimulation of apoptotic and autophagy-mediated cell deaths are effective strategy for anticancer therapies. AIM: The aim of the study is to determine the role of the extract on both apoptotic and autophagic cell death in HeLa cell line. METHODS: The cell viability of C...
2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27731832/report-renovation-of-a-traditional-ergh-al-nassa-pill-hab-to-a-standard-pharmaceutical-molded-tablet
#13
Arman Zargaran, Saeid Daneshamouz, Gholamreza Kordafshari, Abdolali Mohagheghzadeh
The Ergh-al-Nassa pill (Hab) is a traditional combination suggested as one of the most effective preparations useful for treatment of sciatica. Although traditional preparations can be applied as new therapeutic drugs for investigations and clinical trials, they need to be reformulated to achieve pharmacopoeial standards for modern medicine. In this research, based on seven traditional Persian pharmacopeias for Ergh-al-NassaHab, nine different molded tablets were reformulated. Each formulation comprised the same amount of colchicum, ginger, aloe and yellow myrobalan fruit...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27569095/in-vitro-anticancer-and-cytotoxic-activities-of-some-plant-extracts-on-hela-and-vero-cell-lines
#14
Fulya Tugba Artun, Ali Karagoz, Gul Ozcan, Gulay Melikoglu, Sezin Anil, Sukran Kultur, Nurhayat Sutlupinar
PURPOSE: The aim of our study was to evaluate the effect of in vitro anticancer and cytotoxic activity of the methanolic extracts of 14 medicinal plants, 8 of which are endemic species in Anatolia, against the human HeLa cervical cancer cell line and to compare to the normal African green monkey kidney epithelial cell line (Vero) using the MTT colorimetric assay. METHODS: Values for cytotoxicity measured by MTT assay were expressed as the concentration that causes 50% decrease in cell viability (IC50, μg/mL)...
May 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27516658/categorization-of-cathartic-purgative-medicines-mentioned-in-tpm-resources-according-to-their-specific-function
#15
Jafar Abolghasemi
BACKGROUND: According to traditional Persian medicine (TPM) resources, the human digestive system includes four steps. In the first step, gastric digestion, the ingested food pours into the stomach and changes into the leachate called chylous due to the heat produced in the stomach. In the second step, hepatic digestion, the chylous enters in the liver through mesenteric vessels and transforms into the quadruple humors, sanguine, phlegm, bile and black bile due to the liver heat. In the case of humor predominance, using moshel or cathartic medicines is considered as a strategic medical plan...
May 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27454208/therapeutic-use-of-colchicine-and-its-derivatives-a-patent-review
#16
Anita Mandhare, Paromita Banerjee
INTRODUCTION: Colchicine, the major alkaloid extracted from the meadow saffron (Colchicum autumnale) is one of the most prominent natural products belonging to the class of organic compounds known as tropones. Colchicine's medicinal properties have been long-known, but it has been attracting renewed attention due to its action as an antimitotic agent. AREAS COVERED: This review presents an update and analysis of the patents claiming therapeutic activity of colchicine and its derivatives published in the last five years (2010-2015)...
July 29, 2016: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/27449046/a-novel-colchicine-based-microtubule-inhibitor-exhibits-potent-antitumor-activity-by-inducing-mitochondrial-mediated-apoptosis-in-mia-paca-2-pancreatic-cancer-cells
#17
Ashok Kumar, Baljinder Singh, Girish Mahajan, Parduman R Sharma, Sandip B Bharate, Mubashir J Mintoo, Dilip M Mondhe
Colchicine, an antimitotic alkaloid isolated from Colchicum autumnale, is a classical drug for treatment of gout and familial Mediterranean fever. It causes antiproliferative effects through the inhibition of microtubule formation, which leads to mitotic arrest and cell death by apoptosis. Here, we report that a novel colchicine analog, 4o (N-[(7S)-1,2,3-trimethoxy-9-oxo-10-[3-(trifluoromethyl)-4-chlorophenylamino]-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide), which exhibited potent anticancer activities both in vitro and in vivo...
October 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27406462/effects-of-colchicine-on-pericardial-diseases-a-review-of-the-literature-and-current-evidence
#18
REVIEW
Syed Raza Shah, Richard Alweis, Syed Arbab Shah, Mohammad Hussham Arshad, Adil Al-Karim Manji, Arham Amir Arfeen, Maheen Javed, Syed Muhammad Shujauddin, Rida Irfan, Sakina Shabbir, Shehryar Shaikh
Colchicine, extracted from the colchicum autumnale plant, used by the ancient Greeks more than 20 centuries ago, is one of the most ancient drugs still prescribed even today. The major mechanism of action is binding to microtubules thereby interfering with mitosis and subsequent modulation of polymorphonuclear leukocyte function. Colchicine has long been of interest in the treatment of cardiovascular disease; however, its efficacy and safety profile for specific conditions have been variably established in the literature...
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27330389/bilateral-acute-iris-transillumination-case-report
#19
Cumali Degirmenci, Suzan Guven Yilmaz, Melis Palamar, Halil Ates
Bilateral acute iris transillumination (BAIT) is a recently defined disease characterized with bilateral acute, severe pigment dispersion of iris and pupil sphincter paralysis. The etiopathogenesis of the disease is unknown, but antibiotics such as moxifloxacin, clarithromycin, viral infections, and fumigation therapies were considered as probable etiologic factors. A 33-year-old female was referred to our clinic for acute iridocyclitis refractory to azathioprine, colchicum and corticosteroid treatments. Ophthalmic examination revealed bilateral pigment dispersion, significant iris transillumination, heavy pigment deposition in iridocorneal angle, and elevated intraocular pressure...
April 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/27169190/comparison-of-seeds-of-colchicum-speciosum-and-gloriosa-superba-in-respect-to-colchicine-and-colchicoside-contents-by-rp-lc
#20
Mehmet Gumustas, Derya Çiçek Polat, Ceyda S Kiliç, Kemalettin Akalin, Sibel A Ozkan, Maksut Coşkun
In this study, colchicine (CLN) and colchicoside (CLS) contents of the methanolic extracts of the seeds of Colchicum speciosum Steven that were collected from Uzungöl, Trabzon and also the seeds belonging to two different samples of Gloriosa superba Linn. imported from India were compared by using RP-LC (Reversed Phase High Pressure Liquid Chromatography). This proposed method is advantageous in terms of sample preparation and selective separation of the compounds. Also the method was successfully validated in accordance with the International Conference on Harmonization (ICH) guideline acceptance criteria for system suitability, linearity and range, precision, specificity and accuracy...
March 2016: Natural Product Communications
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