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Arman Zargaran, Saeid Daneshamouz, Gholamreza Kordafshari, Abdolali Mohagheghzadeh
The Ergh-al-Nassa pill (Hab) is a traditional combination suggested as one of the most effective preparations useful for treatment of sciatica. Although traditional preparations can be applied as new therapeutic drugs for investigations and clinical trials, they need to be reformulated to achieve pharmacopoeial standards for modern medicine. In this research, based on seven traditional Persian pharmacopeias for Ergh-al-NassaHab, nine different molded tablets were reformulated. Each formulation comprised the same amount of colchicum, ginger, aloe and yellow myrobalan fruit...
September 2016: Pakistan Journal of Pharmaceutical Sciences
Fulya Tugba Artun, Ali Karagoz, Gul Ozcan, Gulay Melikoglu, Sezin Anil, Sukran Kultur, Nurhayat Sutlupinar
PURPOSE: The aim of our study was to evaluate the effect of in vitro anticancer and cytotoxic activity of the methanolic extracts of 14 medicinal plants, 8 of which are endemic species in Anatolia, against the human HeLa cervical cancer cell line and to compare to the normal African green monkey kidney epithelial cell line (Vero) using the MTT colorimetric assay. METHODS: Values for cytotoxicity measured by MTT assay were expressed as the concentration that causes 50% decrease in cell viability (IC50, μg/mL)...
May 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Jafar Abolghasemi
BACKGROUND: According to traditional Persian medicine (TPM) resources, the human digestive system includes four steps. In the first step, gastric digestion, the ingested food pours into the stomach and changes into the leachate called chylous due to the heat produced in the stomach. In the second step, hepatic digestion, the chylous enters in the liver through mesenteric vessels and transforms into the quadruple humors, sanguine, phlegm, bile and black bile due to the liver heat. In the case of humor predominance, using moshel or cathartic medicines is considered as a strategic medical plan...
May 2016: Iranian Journal of Medical Sciences
Anita Mandhare, Paromita Banerjee
INTRODUCTION: Colchicine, the major alkaloid extracted from the meadow saffron (Colchicum autumnale) is one of the most prominent natural products belonging to the class of organic compounds known as tropones. Colchicine's medicinal properties have been long-known, but it has been attracting renewed attention due to its action as an antimitotic agent. AREAS COVERED: This review presents an update and analysis of the patents claiming therapeutic activity of colchicine and its derivatives published in the last five years (2010-2015)...
July 29, 2016: Expert Opinion on Therapeutic Patents
Ashok Kumar, Baljinder Singh, Girish Mahajan, Parduman R Sharma, Sandip B Bharate, Mubashir J Mintoo, Dilip M Mondhe
Colchicine, an antimitotic alkaloid isolated from Colchicum autumnale, is a classical drug for treatment of gout and familial Mediterranean fever. It causes antiproliferative effects through the inhibition of microtubule formation, which leads to mitotic arrest and cell death by apoptosis. Here, we report that a novel colchicine analog, 4o (N-[(7S)-1,2,3-trimethoxy-9-oxo-10-[3-(trifluoromethyl)-4-chlorophenylamino]-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide), which exhibited potent anticancer activities both in vitro and in vivo...
July 24, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Syed Raza Shah, Richard Alweis, Syed Arbab Shah, Mohammad Hussham Arshad, Adil Al-Karim Manji, Arham Amir Arfeen, Maheen Javed, Syed Muhammad Shujauddin, Rida Irfan, Sakina Shabbir, Shehryar Shaikh
Colchicine, extracted from the colchicum autumnale plant, used by the ancient Greeks more than 20 centuries ago, is one of the most ancient drugs still prescribed even today. The major mechanism of action is binding to microtubules thereby interfering with mitosis and subsequent modulation of polymorphonuclear leukocyte function. Colchicine has long been of interest in the treatment of cardiovascular disease; however, its efficacy and safety profile for specific conditions have been variably established in the literature...
2016: Journal of Community Hospital Internal Medicine Perspectives
Cumali Degirmenci, Suzan Guven Yilmaz, Melis Palamar, Halil Ates
Bilateral acute iris transillumination (BAIT) is a recently defined disease characterized with bilateral acute, severe pigment dispersion of iris and pupil sphincter paralysis. The etiopathogenesis of the disease is unknown, but antibiotics such as moxifloxacin, clarithromycin, viral infections, and fumigation therapies were considered as probable etiologic factors. A 33-year-old female was referred to our clinic for acute iridocyclitis refractory to azathioprine, colchicum and corticosteroid treatments. Ophthalmic examination revealed bilateral pigment dispersion, significant iris transillumination, heavy pigment deposition in iridocorneal angle, and elevated intraocular pressure...
April 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
Mehmet Gumustas, Derya Çiçek Polat, Ceyda S Kiliç, Kemalettin Akalin, Sibel A Ozkan, Maksut Coşkun
In this study, colchicine (CLN) and colchicoside (CLS) contents of the methanolic extracts of the seeds of Colchicum speciosum Steven that were collected from Uzungöl, Trabzon and also the seeds belonging to two different samples of Gloriosa superba Linn. imported from India were compared by using RP-LC (Reversed Phase High Pressure Liquid Chromatography). This proposed method is advantageous in terms of sample preparation and selective separation of the compounds. Also the method was successfully validated in accordance with the International Conference on Harmonization (ICH) guideline acceptance criteria for system suitability, linearity and range, precision, specificity and accuracy...
March 2016: Natural Product Communications
Murat Nihat Arslan, Ayşe Özgün, Taner Daş, Durmuş Kumru, Bülent Şam, Sermet Koç
Colchicine is derived from Colchicum autumnale and Gloriosa superba and is used to treat acute gout and familial Mediterranean fever (FMF). Musculoskeletal adverse effects range from myopathy to rhabdomyolysis. An 18-year-old woman, with a 2-year history of FMF treated with colchicine, took 9 colchicine pills (4.5 mg) to relieve severe abdominal pain. On the sixth day of hospitalization, the patient's condition worsened, and she died. As this was a case of fatal poisoning, a forensic autopsy was performed, and the cause of death was determined to be complications of muscle destruction due to colchicine intoxication with the findings of myocytolysis, positive antimyoglobin antibody staining kidney tubules...
June 2016: American Journal of Forensic Medicine and Pathology
Christian Scheffer, Marion Debus, Christian Heckmann, Dirk Cysarz, Matthias Girke
Introduction. Goitre with euthyroid function or with subclinical or mild hyperthyroidism due to thyroid autonomy is common. In anthroposophic medicine various thyroid disorders are treated with Colchicum autumnale (CAU). We examined the effects of CAU in patients with goitre of both functional states. Patients and methods. In an observational study, 24 patients with goitre having suppressed thyroid stimulating hormone (TSH) levels with normal or slightly elevated free thyroxine (fT4) and free triiodothyronine (fT3) (group 1, n = 12) or normal TSH, fT3, and fT4 (group 2, n = 12) were included...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Ashok Kumar, Baljinder Singh, Parduman R Sharma, Sandip B Bharate, Ajit K Saxena, D M Mondhe
Colchicine is a tubulin-binding natural product isolated from Colchicum autumnale. Here we report the in vitro anticancer activity of C-ring modified semi-synthetic derivative of colchicine; N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(4-phenyl-piperidin-1-yl)-5,6,7,9 tetrahydrobenzo[a]heptalen-7-yl]acetamide (4h) on colon cancer HCT-116 cell line. The compound 4h was screened for anti-proliferative activity against different human cancer cell lines and was found to exhibit higher cytotoxicity against colon cancer cell lines HCT-116 and Colo-205 with IC50 of 1 and 0...
March 2016: Cell Biochemistry and Function
Xiucai Guo, Dongju Lin, Weiwei Li, Kai Wang, Ying Peng, Jiang Zheng
Colchicine, an alkaloid existing in plants of Liliaceous colchicum, has been widely used in the treatment of gout and familial Mediterranean fever. The administration of colchicine was found to cause liver injury in humans. The mechanisms of colchicine-induced liver toxicity remain unknown. The objectives of this study were to determine the electrophilicities of demethylation metabolites of colchicine and investigate the protein adductions derived from the reactive metabolites of colchicine. Four demethylated colchicine (1-, 2-, 3-, and 10-DMCs), namely, M1-M4, were detected in colchicine-fortified microsomal incubations...
March 21, 2016: Chemical Research in Toxicology
Lejla Bajramović-Omeragić, Lejla Čalkić, Eldira Hadžić, Ibrahim Aličkovič
Colchicine poisonings are serious and highly fatal conditions that occur as a result of food poisoning from plants that contain this alkaloid or overdose with drug containing colchicine. The leaves of edible wild garlic because of their similarity are often replaced with highly poisonous leaves of autumn crocus, causing poisoning. Described are two cases of food poisoning with Colchicum autumnale, who had similar symptoms in the initial stage, but different clinical course and outcome. Signs of poisoning require early identification and intensive supportive therapy, which increases the chances of survival...
September 2015: Lijec̆nic̆ki Vjesnik
Mohd Fahim, Mhaveer Singh, Y T Kamal, Hayat M Mukhtar, Sayeed Ahmad
BACKGROUND: Colchicine is a main alkaloid present in bitter and sweet variety of colchicum (Colchicum luteum Baker), which have been reported to possess anti-rheumatic, anti-gout, and anticancer potential. Colchicum is an important ingredient of several Unani and Herbal formulations. Quantification of colchicine will play a great role in quality control of these formulations. Hence, a high-performance thin layer chromatographic (TLC) method has been developed for the analysis of colchicine in Unani formulations of various dosage forms such as hubb (tablet) and capsules...
October 2015: Journal of Pharmacy & Bioallied Sciences
Cristina Cortinovis, Francesca Caloni
Alkaloids, nitrogen-containing secondary plant metabolites, are of major interest to veterinary toxicology because of their occurrence in plant species commonly involved in animal poisoning. Based on epidemiological data, the poisoning of cattle and horses by alkaloid-containing plants is a relatively common occurrence in Europe. Poisoning may occur when the plants contaminate hay or silage or when forage alternatives are unavailable. Cattle and horses are particularly at risk of poisoning by Colchicum autumnale (meadow saffron), Conium maculatum (poison hemlock), Datura stramonium (jimson weed), Equisetum palustre (marsh horsetail), Senecio spp...
December 2015: Toxins
Coralie Galland-Decker, Alexia Charmoy, Philippe Jolliet, Olivier Spertini, Olivier Hugli, Olivier Pantet
BACKGROUND: Wild garlic and related plants are increasingly sought after by fans of natural products. They can be confused with other plants containing colchicine and cause potentially fatal intoxications. CASE REPORT: We report a case of accidental poisoning by Colchicum autumnale, which was mistaken for wild garlic (Allium ursinum). The patient initially presented with mild gastrointestinal symptoms, but progressed rapidly to agranulocytosis, paraparesis, and delirium before the causative agent was identified...
January 2016: Journal of Emergency Medicine
P W Crous, M J Wingfield, J Guarro, M Hernández-Restrepo, D A Sutton, K Acharya, P A Barber, T Boekhout, R A Dimitrov, M Dueñas, A K Dutta, J Gené, D E Gouliamova, M Groenewald, L Lombard, O V Morozova, J Sarkar, M Th Smith, A M Stchigel, N P Wiederhold, A V Alexandrova, I Antelmi, J Armengol, I Barnes, J F Cano-Lira, R F Castañeda Ruiz, M Contu, Pr R Courtecuisse, A L da Silveira, C A Decock, A de Goes, J Edathodu, E Ercole, A C Firmino, A Fourie, J Fournier, E L Furtado, A D W Geering, J Gershenzon, A Giraldo, D Gramaje, A Hammerbacher, X-L He, D Haryadi, W Khemmuk, A E Kovalenko, R Krawczynski, F Laich, C Lechat, U P Lopes, H Madrid, E F Malysheva, Y Marín-Felix, M P Martín, L Mostert, F Nigro, O L Pereira, B Picillo, D B Pinho, E S Popov, C A Rodas Peláez, S Rooney-Latham, M Sandoval-Denis, R G Shivas, V Silva, M M Stoilova-Disheva, M T Telleria, C Ullah, S B Unsicker, N A van der Merwe, A Vizzini, H-G Wagner, P T W Wong, A R Wood, J Z Groenewald
Novel species of fungi described in the present study include the following from Malaysia: Castanediella eucalypti from Eucalyptus pellita, Codinaea acacia from Acacia mangium, Emarcea eucalyptigena from Eucalyptus brassiana, Myrtapenidiella eucalyptorum from Eucalyptus pellita, Pilidiella eucalyptigena from Eucalyptus brassiana and Strelitziana malaysiana from Acacia mangium. Furthermore, Stachybotrys sansevieriicola is described from Sansevieria ehrenbergii (Tanzania), Phacidium grevilleae from Grevillea robusta (Uganda), Graphium jumulu from Adansonia gregorii and Ophiostoma eucalyptigena from Eucalyptus marginata (Australia), Pleurophoma ossicola from bone and Plectosphaerella populi from Populus nigra (Germany), Colletotrichum neosansevieriae from Sansevieria trifasciata, Elsinoë othonnae from Othonna quinquedentata and Zeloasperisporium cliviae (Zeloasperisporiaceae fam...
June 2015: Persoonia
Julie Boisramé-Helms, Hassène Rahmani, Laure Stiel, Christine Tournoud, Philippe Sauder
CONTEXT: Ingestions of Colchicum autumnale may lead to severe poisoning. It begins with gastrointestinal symptoms and leukocytosis, followed by multi-organ failure with shock and a possible late recovery phase. Mortality is highly dependent on the ingested dose. We report a case of accidental C. autumnale poisoning with refractory cardiogenic shock and eventual survival after extracorporeal life support (ECLS). CASE DETAILS: A 68-year-old woman was admitted to the intensive care unit (ICU) on day 3 after ingestion of C...
2015: Clinical Toxicology
Carsten Gründemann, Christoph Diegel, Barbara Sauer, Manuel Garcia-Käufer, Roman Huber
BACKGROUND: Preparations from anthroposophical medicine (AM) are clinically used to treat inflammatory disorders. We wanted to investigate effects of a selection of AM medications for parenteral use in cell-based systems in vitro. METHODS: Colchicum officinale tuber D3, Mandragora D3, Rosmarinus officinale 5% and Bryophyllum 5% were selected for the experiments. Induction of apoptosis and necrosis (human lymphocytes and dendritic cells [DCs]) and proliferation of lymphocytes as well as maturation (expression of CD14, CD83 and CD86) and cytokine secretion (IL-10, IL12p70) of DCs were analyzed...
2015: BMC Complementary and Alternative Medicine
Pham Anh Thi Nguyen, Jung Sung Kim, Joo-Hwan Kim
The complete chloroplast genome of two colchicine medicinal plants is reported for the first time. Deletion of ycf 15 gene occurred only in Colchicum but not in Gloriosa and suggests this as a potential marker for delineating the two species. Colchicum autumnale L. and Gloriosa superba L. are well-known sources of colchicine, a type of alkaloid and an ancient anti-inflammatory drug used to prevent gout. Accordingly, this alkaloid has been used as a chemical marker for identifying the expanded Colchicaceae family...
July 2015: Planta
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