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Critical power performance

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https://www.readbyqxmd.com/read/27918663/comparison-of-critical-power-and-w-derived-from-two-or-three-maximal-tests
#1
Len Parker Simpson, Mehdi Kordi
PURPOSE: Typically, accessing the asymptote (Critical Power; CP) and curvature constant (W') parameters of the hyperbolic power-duration relationship requires multiple constant-power, exhaustive exercise trials, spread over several visits. However, more recently single-visit protocols and personal power meters have been used. We investigated the practicality of using a two-trial, single-visit protocol in providing reliable CP & W' estimates. METHODS: 8 trained cyclists underwent 3- and 12-min maximal exercise trials in a single session to derive (2-trial) CP & W' estimates...
December 5, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27916703/oogenesis_pred-a-sequence-based-method-for-predicting-oogenesis-proteins-by-six-different-modes-of-chou-s-pseudo-amino-acid-composition
#2
Maryam Rahimi, Mohammad Reza Bakhtiarizadeh, Abdollah Mohammadi-Sangcheshmeh
Regarding to critical roles of oogenesis in formation of ova or unfertilized eggs from the oogonia by mitotic division and subsequent differentiation, the identification of oogenesis-related proteins is of great interest. However, the experimental determination of proteins involved in oogenesis is expensive, time consuming and labor-intensive. Therefore, a new powerful discriminating model is indispensable for classifying oogenesis/non-oogenesis-related proteins with high accuracy and precision. Hereby, for the first time we developed a support vector machine based oogenesis protein prediction method which differentiates oogenesis from non-oogenesis proteins...
December 1, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27910847/efficiency-limits-for-photoelectrochemical-water-splitting
#3
Katherine T Fountaine, Hans Joachim Lewerenz, Harry A Atwater
Theoretical limiting efficiencies have a critical role in determining technological viability and expectations for device prototypes, as evidenced by the photovoltaics community's focus on detailed balance. However, due to their multicomponent nature, photoelectrochemical devices do not have an equivalent analogue to detailed balance, and reported theoretical efficiency limits vary depending on the assumptions made. Here we introduce a unified framework for photoelectrochemical device performance through which all previous limiting efficiencies can be understood and contextualized...
December 2, 2016: Nature Communications
https://www.readbyqxmd.com/read/27910544/absolute-calibration-of-neutron-detectors-on-the-c-2u-advanced-beam-driven-frc
#4
R M Magee, R Clary, S Korepanov, F Jauregui, I Allfrey, E Garate, T Valentine, A Smirnov
In the C-2U fusion energy experiment, high power neutral beam injection creates a large fast ion population that sustains a field-reversed configuration (FRC) plasma. The diagnosis of the fast ion pressure in these high-performance plasmas is therefore critical, and the measurement of the flux of neutrons from the deuterium-deuterium (D-D) fusion reaction is well suited to the task. Here we describe the absolute, in situ calibration of scintillation neutron detectors via two independent methods: firing deuterium beams into a high density gas target and calibration with a 2 × 10(7) n/s AmBe source...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27906408/spatially-uniform-resistance-switching-of-low-current-high-endurance-titanium-niobium-oxide-memristors
#5
Suhas Kumar, Noraica Davila, Ziwen Wang, Xiaopeng Huang, John Paul Strachan, David Vine, A L David Kilcoyne, Yoshio Nishi, R Stanley Williams
We analyzed micrometer-scale titanium-niobium-oxide prototype memristors, which exhibited low write-power (<3 μW) and energy (<200 fJ per bit per μm(2)), low read-power (∼nW), and high endurance (>millions of cycles). To understand their physico-chemical operating mechanisms, we performed in operando synchrotron X-ray transmission nanoscale spectromicroscopy using an ultra-sensitive time-multiplexed technique. We observed only spatially uniform material changes during cell operation, in sharp contrast to the frequently detected formation of a localized conduction channel in transition-metal-oxide memristors...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27903483/therapeutic-benefits-and-adverse-effects-of-combined-pro-angiogenic-gene-therapy-in-mouse-critical-leg-ischemia
#6
Benoît Lebas, Julien Galley, Edith Renaud-Gabardos, Françoise Pujol, Françoise Lenfant, Barbara Garmy-Susini, Xavier Chaufour, Anne-Catherine Prats
OBJECTIVE: Critical leg ischemia (CLI) represents the ultimate stage of peripheral arterial disease. Despite current surgery advances, patients with CLI have limited therapeutic options. Therapeutic angiogenesis thus appears as a powerful approach, aiming to stimulate vessel formation by angiogenic molecules administration. In this context, combined gene therapy has proved the most efficient. The present study aims to compare, in a preclinical mouse model, the therapeutic benefit of a combination of two angiogenic factors FGF2 (fibroblast growth factor 2) and Cyr61 using plasmid and viral vectors, able to generate short or long-term transgene expression in the leg, respectively...
November 26, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27898829/gapit-version-2-an-enhanced-integrated-tool-for-genomic-association-and-prediction
#7
You Tang, Xiaolei Liu, Jiabo Wang, Meng Li, Qishan Wang, Feng Tian, Zhongbin Su, Yuchun Pan, Di Liu, Alexander E Lipka, Edward S Buckler, Zhiwu Zhang
Most human diseases and agriculturally important traits are complex. Dissecting their genetic architecture requires continued development of innovative and powerful statistical methods. Corresponding advances in computing tools are critical to efficiently use these statistical innovations and to enhance and accelerate biomedical and agricultural research and applications. The genome association and prediction integrated tool (GAPIT) was first released in 2012 and became widely used for genome-wide association studies (GWAS) and genomic prediction...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27897669/domain-general-stroop-performance-and-hemispheric-asymmetries-a-resting-state-eeg-study
#8
Ettore Ambrosini, Antonino Vallesi
The ability to suppress irrelevant information while executing a task or interference resistance is a function of pFC that is critical for successful goal-directed human behavior. In the study of interference resistance and, more generally, executive functions, two key questions are still open: Does pFC contribute to cognitive control abilities through lateralized but domain-general mechanisms or through hemispheric specialization of domain-specific processes? And what are the underlying causes of interindividual differences in executive control performance? To shed light on these issues, here we employed an interindividual difference approach to investigate whether participants' hemispheric asymmetry in resting-state electrophysiological brain dynamics may reflect their variability in domain-general interference resistance...
November 29, 2016: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/27893905/critical-care-interprofessional-education-exploring-conflict-and-power-lessons-learned
#9
Mary Louanne Friend, Richard D Friend, Cassandra Ford, Patrick J Ewell
BACKGROUND: The purpose of this mixed-methods study was to evaluate the effects of an innovative critical care interprofessional education intervention on prelicensure nursing and medical students at a large public university. The class provided opportunities for students to (a) explore stereotypes about each respective profession, (b) examine the occurrence and effects of interprofessional conflict in high-acuity areas, and (c) explore conflict resolution techniques while learning how to perform critical care procedures as a team...
December 1, 2016: Journal of Nursing Education
https://www.readbyqxmd.com/read/27888165/clinical-effectiveness-of-adjunctive-antimicrobial-photodynamic-therapy-for-residual-pockets-during-supportive-periodontal-therapy-a-systematic-review-and-meta-analysis
#10
Dong Xue, Ying Zhao
PURPOSE: To evaluate the clinical efficacy of antimicrobial photodynamic therapy (aPDT) adjunctive to scaling and root planing (SRP) in the treatment of residual pockets for chronic periodontitis patients on supportive periodontal therapy (SPT). METHOD: Bibliographic databases of MEDLINE and Cochrane Library were thoroughly searched up to July 2016 for eligible randomized controlled trials (RCTs). Mean differences (MD) and the corresponding 95% confidence intervals (CI) were synthesized for probing depth (PD) reduction and clinical attachment level (CAL) gain...
November 22, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27887981/predictors-of-mortality-in-the-critically-ill-cirrhotic-patient-is-the-model-for-end-stage-liver-disease-enough
#11
Alagappan Annamalai, Megan Y Harada, Melissa Chen, Tram Tran, Ara Ko, Eric J Ley, Miriam Nuno, Andrew Klein, Nicholas Nissen, Mazen Noureddin
BACKGROUND: Critically ill cirrhotics urgently require liver transplantation but are at high risk for perioperative mortality. The Model for End-Stage Liver Disease (MELD) score, recently updated to incorporate serum sodium, estimates survival probability in patients with cirrhosis but needs further evaluation in the critically ill. The purpose of this study was to evaluate the predictive power of intensive care unit (ICU) admission MELD scores and identify clinical risk factors associated with increased mortality...
November 22, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27882893/protocol-mythbusters-a-universal-procedure-for-sample-preparation-for-mass-spectrometry
#12
Anna Drabik, Joanna Ner-Kluza, Anna Bodzon-Kulakowska, Piotr Suder
Improvements in proteomic strategies from the development of new and robust separation and identification techniques have led to broad applications of proteomics to solve numerous biological questions. For all analyses, sample quality is unquestionably a critical factor; therefore protein extraction is of outmost importance. The ideal extraction method should provide reproducible spectra of the most comprehensive repertoire of proteins, while minimizing sample loss and degradation. It is already known that to capture the whole proteome is an unenforceable task...
2016: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/27879505/the-effect-of-transpedicular-screw-design-on-its-performance-in-vertebral-bone-under-tensile-loads-a-parametric-study
#13
Ron N Alkaly, Dan L Bader
STUDY DESIGN: A biomechanical study using bovine thoracolumbar spines. OBJECTIVE: To study investigated whether thread design parameters aimed at altering the state of stress at the screw-bone interface increase the screw's holding power. SUMMARY AND BACKGROUND DATA: Internal spinal fixators utilizing transpedicular screw fixation are used to achieve early stabilization of the injured spine in a range of clinical conditions. Despite advances in the design of internal spinal fixation systems, implant loosening, and catastrophic failures at the screw-bone interface remains a serious complication in adult spine surgery...
December 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27876347/improved-conventional-and-microwave-assisted-silylation-protocols-for-simultaneous-gas-chromatographic-determination-of-tocopherols-and-sterols-method-development-and-multi-response-optimization
#14
Mahesha M Poojary, Paolo Passamonti
This paper reports on improved conventional thermal silylation (CTS) and microwave-assisted silylation (MAS) methods for simultaneous determination of tocopherols and sterols by gas chromatography. Reaction parameters in each of the methods developed were systematically optimized using a full factorial design followed by a central composite design. Initially, experimental conditions for CTS were optimized using a block heater. Further, a rapid MAS was developed and optimized. To understand microwave heating mechanisms, MAS was optimized by two distinct modes of microwave heating: temperature-controlled MAS and power-controlled MAS, using dedicated instruments where reaction temperature and microwave power level were controlled and monitored online...
December 9, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27875130/discriminative-ocular-artifact-correction-for-feature-learning-in-eeg-analysis
#15
Xinyang Li, Cuntai Guan, Haihong Zhang, Kai Keng Ang
Electrooculogram (EOG) artifact contamination is a common critical issue in general electroencephalogram (EEG) studies as well as in brain computer interface (BCI) research. It is especially challenging when dedicated EOG channels are unavailable or when there are very few EEG channels available for ICA-based ocular artifact removal. It is even more challenging to avoid loss of the signal of interest during the artifact correction process, where the signal of interest can be multiple magnitudes weaker than the artifact...
November 16, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27874033/influence-of-combined-fundamental-potentials-in-a-nonlinear-vibration-energy-harvester
#16
Pranay Podder, Dhiman Mallick, Andreas Amann, Saibal Roy
Ambient mechanical vibrations have emerged as a viable energy source for low-power wireless sensor nodes aiming the upcoming era of the 'Internet of Things'. Recently, purposefully induced dynamical nonlinearities have been exploited to widen the frequency spectrum of vibration energy harvesters. Here we investigate some critical inconsistencies between the theoretical formulation and applications of the bistable Duffing nonlinearity in vibration energy harvesting. A novel nonlinear vibration energy harvesting device with the capability to switch amidst individually tunable bistable-quadratic, monostable-quartic and bistable-quartic potentials has been designed and characterized...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27872745/critical-review-of-sham-surgery-clinical-trials-confounding-factors-analysis
#17
REVIEW
Massimo Ciccozzi, Rosa Menga, Giovanna Ricci, Massimiliano Andrea Vitali, Silvia Angeletti, Ascanio Sirignano, Vittoradolfo Tambone
OBJECTIVE: Sham surgery (placebo surgery) is an intervention that omits the step thought to be therapeutically necessary. In surgical clinical trials, sham surgery serves an analogous purpose to placebo drugs, neutralizing biases such as the placebo effect. A critical review was performed to study the statistical relevance of the clinical trials about sham surgery in the light of potential confounding factors. MATERIALS AND METHODS: For the critical review 52 articles were included...
December 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27869043/nano-localized-thermal-analysis-and-mapping-of-surface-and-sub-surface-thermal-properties-using-scanning-thermal-microscopy-sthm
#18
Maria J Pereira, Joao S Amaral, Nuno J O Silva, Vitor S Amaral
Determining and acting on thermo-physical properties at the nanoscale is essential for understanding/managing heat distribution in micro/nanostructured materials and miniaturized devices. Adequate thermal nano-characterization techniques are required to address thermal issues compromising device performance. Scanning thermal microscopy (SThM) is a probing and acting technique based on atomic force microscopy using a nano-probe designed to act as a thermometer and resistive heater, achieving high spatial resolution...
November 21, 2016: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/27867292/new-impella-cardiac-power-device-used-in-patient-with-cardiogenic-shock-due-to-nonischemic-cardiomyopathy
#19
Marek Cena, Frances Karam, Rajesh Ramineni, Wissam Khalife, Alejandro Barbagelata
The new percutaneous Impella CP (Cardiac Power; Abiomed, Inc., Danvers, MA) was designed to provide a higher level of support than Impella 2.5 (Abiomed, Inc.). We present the first documented case of a patient that was transitioned from the Impella 2.5 to Impella CP. A 48-year-old male patient with no medical history was transferred to our institution with a one day history of worsening shortness of breath. The patient was unstable and found to have monomorphic ventricular tachycardia at 220 beats/min that was cardioverted to normal sinus rhythm...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/27867020/a-randomized-dose-escalation-study-of-intravenous-baclofen-in-healthy-volunteers-clinical-tolerance-and-pharmacokinetics
#20
Natalie S Schmitz, Linda E Krach, Lisa D Coles, Usha Mishra, Suresh K Agarwal, James C Cloyd, Robert L Kriel
BACKGROUND: Abrupt discontinuation of baclofen can result in a potentially severe withdrawal syndrome. The current treatment for baclofen withdrawal is inadequate, resulting in a critical need to develop an alternative method to prevent or treat this withdrawal syndrome. OBJECTIVE: To evaluate the safety profile and pharmacokinetics of oral (PO) and investigational intravenous (IV) baclofen formulations at clinically relevant doses. DESIGN: Randomized, open-label, dose escalation, crossover study SETTING: Contract Research Organization (CRO) METHODS: Three cohorts of 12 healthy adults received single doses of PO baclofen (10mg, 15 mg or 20 mg) and 10-minute infusions of IV baclofen (7...
November 17, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
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