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https://www.readbyqxmd.com/read/28742779/a-novel-method-of-evaluating-key-factors-for-success-in-a-multifaceted-critical-care-fellowship-using-data-envelopment-analysis
#1
Vikram Tiwari, Avinash B Kumar
BACKGROUND: The current system of summative multi-rater evaluations and standardized tests to determine readiness to graduate from critical care fellowships has limitations. We sought to pilot the use of data envelopment analysis (DEA) to assess what aspects of the fellowship program contribute the most to an individual fellow's success. DEA is a nonparametric, operations research technique that uses linear programming to determine the technical efficiency of an entity based on its relative usage of resources in producing the outcome...
July 21, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28736464/the-generalized-higher-criticism-for-testing-snp-set-effects-in-genetic-association-studies
#2
Ian Barnett, Rajarshi Mukherjee, Xihong Lin
It is of substantial interest to study the effects of genes, genetic pathways, and networks on the risk of complex diseases. These genetic constructs each contain multiple SNPs, which are often correlated and function jointly, and might be large in number. However, only a sparse subset of SNPs in a genetic construct is generally associated with the disease of interest. In this article, we propose the generalized higher criticism (GHC) to test for the association between an SNP set and a disease outcome. The higher criticism is a test traditionally used in high-dimensional signal detection settings when marginal test statistics are independent and the number of parameters is very large...
2017: Journal of the American Statistical Association
https://www.readbyqxmd.com/read/28734477/polarity-sensitive-probes-for-superresolution-stimulated-emission-depletion-microscopy
#3
Erdinc Sezgin, Falk Schneider, Victoria Zilles, Iztok Urbančič, Esther Garcia, Dominic Waithe, Andrey S Klymchenko, Christian Eggeling
The lateral organization of molecules in the cellular plasma membrane plays an important role in cellular signaling. A critical parameter for membrane molecular organization is how the membrane lipids are packed. Polarity-sensitive dyes are powerful tools to characterize such lipid membrane order, employing, for example, confocal and two-photon microscopy. The investigation of potential nanodomains, however, requires the use of superresolution microscopy. Here, we test the performance of the polarity-sensitive membrane dyes Di-4-ANEPPDHQ, Di-4-AN(F)EPPTEA, and NR12S in superresolution stimulated emission depletion microscopy...
July 19, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28733178/clinical-usefulness-of-serum-antibodies-as-biomarkers-of-gastrointestinal-and-liver-diseases
#4
REVIEW
Antonio Di Sabatino, Federico Biagi, Marco Lenzi, Luca Frulloni, Marco Vincenzo Lenti, Paolo Giuffrida, Gino Roberto Corazza
The progressively growing knowledge of the pathophysiology of a number of immune-mediated gastrointestinal and liver disorders, including autoimmune atrophic gastritis, coeliac disease, autoimmune enteropathy, inflammatory bowel disease, autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cholangitis and autoimmune pancreatitis, together with the improvement of their detection methods have increased the diagnostic power of serum antibodies. In some cases - coeliac disease and autoimmune atrophic gastritis - they have radically changed gastroenterologists' diagnostic ability, while in others - autoimmune hepatitis, inflammatory bowel disease and autoimmune pancreatitis - their diagnostic performance is still inadequate...
June 23, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28732757/multimodal-exercise-training-in-multiple-sclerosis-a-randomized-controlled-trial-in-persons-with-substantial-mobility-disability
#5
Brian M Sandroff, Rachel E Bollaert, Lara A Pilutti, Melissa L Peterson, Tracy Baynard, Bo Fernhall, Edward McAuley, Robert W Motl
BACKGROUND: Mobility disability is a common, debilitating feature of multiple sclerosis (MS). Exercise training has been identified as an approach to improve MS-related mobility disability. However, exercise randomized controlled trials (RCTs) on mobility in MS have generally not selectively targeted those with the onset of irreversible mobility disability. OBJECTIVES: The current multi-site RCT compared the efficacy of 6-months of supervised, multimodal exercise training with an active control condition for improving mobility, gait, physical fitness, and cognitive outcomes in persons with substantial MS-related mobility disability...
July 18, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28729412/simple-scoring-system-to-predict-in-hospital-mortality-after-surgery-for-infective-endocarditis
#6
Giuseppe Gatti, Andrea Perrotti, Jean-François Obadia, Xavier Duval, Bernard Iung, François Alla, Catherine Chirouze, Christine Selton-Suty, Bruno Hoen, Gianfranco Sinagra, François Delahaye, Pierre Tattevin, Vincent Le Moing, Aniello Pappalardo, Sidney Chocron
BACKGROUND: Aspecific scoring systems are used to predict the risk of death postsurgery in patients with infective endocarditis (IE). The purpose of the present study was both to analyze the risk factors for in-hospital death, which complicates surgery for IE, and to create a mortality risk score based on the results of this analysis. METHODS AND RESULTS: Outcomes of 361 consecutive patients (mean age, 59.1±15.4 years) who had undergone surgery for IE in 8 European centers of cardiac surgery were recorded prospectively, and a risk factor analysis (multivariable logistic regression) for in-hospital death was performed...
July 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28725399/optimizing-performance-of-nonparametric-species-richness-estimators-under-constrained-sampling
#7
Harshana Rajakaruna, D Andrew R Drake, Farrah T Chan, Sarah A Bailey
Understanding the functional relationship between the sample size and the performance of species richness estimators is necessary to optimize limited sampling resources against estimation error. Nonparametric estimators such as Chao and Jackknife demonstrate strong performances, but consensus is lacking as to which estimator performs better under constrained sampling. We explore a method to improve the estimators under such scenario. The method we propose involves randomly splitting species-abundance data from a single sample into two equally sized samples, and using an appropriate incidence-based estimator to estimate richness...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28720183/g-loc-warning-algorithms-based-on-emg-features-of-the-gastrocnemius-muscle
#8
Sungho Kim, Taehwan Cho, Yongkyun Lee, Hyojin Koo, Booyong Choi, Dongsoo Kim
BACKGROUND: G-induced loss of consciousness (G-LOC) is mainly caused by failure to sustain an oxygenated blood supply to the pilot's brain because of the sudden acceleration in the direction of the +Gz axis, and is considered a critical safety issue. The purpose of this study was to develop G-LOC warning algorithms based on monitoring electromyograms (EMG) of the gastrocnemius muscle on the calf. METHODS: EMG data was retrieved from a total of 67 pilots and pilot trainees of the Korean Air Force during high-G training on a human centrifugal simulator...
August 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28715734/simultaneous-algae-polluted-water-treatment-and-electricity-generation-using-a-biocathode-coupled-electrocoagulation-cell-bio-ecc
#9
Yue Dong, Youpeng Qu, Chao Li, Xiaoyu Han, John J Ambuchi, Junfeng Liu, Yanling Yu, Yujie Feng
How to utilize electrocoagulation (EC) technology for algae-polluted water treatment in an energy-efficient manner remains a critical challenge for its widespread application. Herein, a novel biocathode-coupled electrocoagulation cell (bio-ECC) with sacrificial iron anode and nitrifying biocathode was developed. Under different solution conductivities (2.33±0.25mScm(-1) and 4.94±0.55mScm(-1)), the bio-ECC achieved almost complete removal of algae cells. The maximum power densities of 8.41 and 11.33Wm(-3) at corresponding current densities of 48...
June 23, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28710516/perspectives-and-challenges-of-photon-upconversion-nanoparticles-part-i-routes-to-brighter-particles-and-quantitative-spectroscopic-studies
#10
REVIEW
Ute Resch-Genger, Hans H Gorris
Lanthanide-doped photon-upconversion nanoparticles (UCNPs) have been the focus of many research activities in materials and life sciences in the last 15 years because of their potential to convert light between different spectral regions and their unique photophysical properties. To fully exploit the application potential of these fascinating nanomaterials, a number of challenges have to be overcome, such as the low brightness, particularly of small UCNPs, and the reliable quantification of the excitation-power-density-dependent upconversion luminescence...
July 14, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28709260/pneumatic-fractures-in-confined-granular-media
#11
Fredrik K Eriksen, Renaud Toussaint, Antoine L Turquet, Knut J Måløy, Eirik G Flekkøy
We perform experiments where air is injected at a constant overpressure P_{in}, ranging from 5 to 250 kPa, into a dry granular medium confined within a horizontal linear Hele-Shaw cell. The setup allows us to explore compacted configurations by preventing decompaction at the outer boundary, i.e., the cell outlet has a semipermeable filter such that beads are stopped while air can pass. We study the emerging patterns and dynamic growth of channels in the granular media due to fluid flow, by analyzing images captured with a high speed camera (1000 images/s)...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28706157/a-bayesian-pick-the-winner-design-in-a-randomized-phase-ii-clinical-trial
#12
Dung-Tsa Chen, Po-Yu Huang, Hui-Yi Lin, Alberto A Chiappori, Dmitry I Gabrilovich, Eric B Haura, Scott J Antonia, Jhanelle E Gray
PURPOSE: Many phase II clinical trials evaluate unique experimental drugs/combinations through multi-arm design to expedite the screening process (early termination of ineffective drugs) and to identify the most effective drug (pick the winner) to warrant a phase III trial. Various statistical approaches have been developed for the pick-the-winner design but have been criticized for lack of objective comparison among the drug agents. METHODS: We developed a Bayesian pick-the-winner design by integrating a Bayesian posterior probability with Simon two-stage design in a randomized two-arm clinical trial...
July 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28704307/acute-cardiopulmonary-metabolic-and-neuromuscular-responses-to-severe-intensity-intermittent-exercises
#13
Felipe D Lisbôa, João A G Raimundo, Amadeo F Salvador, Kayo L Pereira, Tiago Turnes, Fernando Diefenthaeler, Mariana F M de Oliveira, Fabrizio Caputo
The purpose of this study was to compare cardiopulmonary, neuromuscular, and metabolic responses to severe-intensity intermittent exercises with variable or constant work rate. Eleven cyclists (28 ± 5 years; 74 ± 7 kg; 175 ± 5 cm; 63 ± 4 mL·kg·min) performed the following tests until exhaustion on separate days: 1) an incremental test; 2) in random order, two constant work rate tests at 95% and 110% of the peak power for the determination of Critical Power (CP); 3) 2-4 tests for the determination of the highest power that still permits the achievement of maximal oxygen uptake (PHIGH); and 4) two random severe-intensity intermittent exercises...
July 12, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28704150/measurement-of-ph-exudate-composition-and-temperature-in-wound-healing-a-systematic-review
#14
G Power, Z Moore, T O'Connor
OBJECTIVE: To assess the potential of measurements of pH, exudate composition and temperature in wounds to predict healing outcomes and to identify the methods that are employed to measure them. METHOD: A systematic review based on the outcomes of a search strategy of quantitative primary research published in the English language was conducted. Inclusion criteria limited studies to those involving in vivo and human participants with an existing or intentionally provoked wound, defined as 'a break in the epithelial integrity of the skin', and excluded in vitro and animal studies...
July 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28702921/acl-return-to-sport-guidelines-and-criteria
#15
REVIEW
George J Davies, Eric McCarty, Matthew Provencher, Robert C Manske
PURPOSE OF REVIEW: Because of the epidemiological incidence of anterior cruciate ligament (ACL) injuries, the high reinjury rates that occur when returning back to sports, the actual number of patients that return to the same premorbid level of competition, the high incidence of osteoarthritis at 5-10-year follow-ups, and the effects on the long-term health of the knee and the quality of life for the patient, individualizing the return to sports after ACL reconstruction (ACL-R) is critical...
July 12, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28700603/the-language-of-glove-wireless-gesture-decoder-with-low-power-and-stretchable-hybrid-electronics
#16
Timothy F O'Connor, Matthew E Fach, Rachel Miller, Samuel E Root, Patrick P Mercier, Darren J Lipomi
This communication describes a glove capable of wirelessly translating the American Sign Language (ASL) alphabet into text displayable on a computer or smartphone. The key components of the device are strain sensors comprising a piezoresistive composite of carbon particles embedded in a fluoroelastomer. These sensors are integrated with a wearable electronic module consisting of digitizers, a microcontroller, and a Bluetooth radio. Finite-element analysis predicts a peak strain on the sensors of 5% when the knuckles are fully bent...
2017: PloS One
https://www.readbyqxmd.com/read/28699275/the-concepts-of-asymmetric-and-symmetric-power-can-help-resolve-the-puzzle-of-altruistic-and-cooperative-behaviour
#17
Tim Phillips
Evolutionary theory predicts competition in nature yet altruistic and cooperative behaviour appears to reduce the ability to compete in order to help others compete better. This evolutionary puzzle is usually explained by kin selection where close relatives perform altruistic and cooperative acts to help each other and by reciprocity theory (i.e. direct, indirect and generalized reciprocity) among non-kin. Here, it is proposed that the concepts of asymmetry and symmetry in power and dominance are critical if we are ever to resolve the puzzle of altruism and cooperation towards non-kin...
July 11, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28697057/computerized-virtual-reality-simulation-in-preclinical-dentistry-can-a-computerized-simulator-replace-the-conventional-phantom-heads-and-human-instruction
#18
Anastasios Plessas
In preclinical dental education, the acquisition of clinical, technical skills, and the transfer of these skills to the clinic are paramount. Phantom heads provide an efficient way to teach preclinical students dental procedures safely while increasing their dexterity skills considerably. Modern computerized phantom head training units incorporate features of virtual reality technology and the ability to offer concurrent augmented feedback. The aims of this review were to examine and evaluate the dental literature for evidence supporting their use and to discuss the role of augmented feedback versus the facilitator's instruction...
July 10, 2017: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/28696459/the-origin-of-the-debye-relaxation-in-liquid-water-and-fitting-the-high-frequency-excess-response
#19
Daniel C Elton
We critically review the literature on the Debye absorption peak of liquid water and the excess response found on the high frequency side of the Debye peak. We find a lack of agreement on the microscopic phenomena underlying both of these features. To better understand the molecular origin of Debye peak we ran large scale molecular dynamics simulations and performed several different distance-dependent decompositions of the low frequency dielectric spectra, finding that it involves processes that take place on scales of 1...
July 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28695726/water-soluble-2d-transition-metal-dichalcogenides-as-the-hole-transport-layer-for-highly-efficient-and-stable-p-i-n-perovskite-solar-cells
#20
Peng Huang, Zhaowei Wang, Yanfeng Liu, Kaicheng Zhang, Ligang Yuan, Yi Zhou, Bo Song, Yongfang Li
As a hole-transport layer (HTL) material, poly(3,4-ethylenedioxythiophene):polystyrene-sulfonate (PEDOT:PSS) was often criticized for its intrinsic acidity and hygroscopic effect that would in the long run affect the stability of perovskite solar cells (Pero-SCs). As alternatives, herein water-soluble two-dimensional (2D) transition metal dichalcogenides (TMDs), such as MoS2 and WS2 were used as HTLs in p-i-n Pero-SCs. It was found that the content of 1T phase in 2D TMDs HTLs is centrally important to the power conversion efficiencies (PCEs) of Pero-SCs, and the 1T-rich TMDs (as achieved from exfoliation and without postheating) lead to much higher PCEs...
July 19, 2017: ACS Applied Materials & Interfaces
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