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Power duration relationship

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https://www.readbyqxmd.com/read/28086966/predictive-value-of-non-fasting-remnant-cholesterol-for-short-term-outcome-of-diabetics-with-new-onset-stable-coronary-artery-disease
#1
Li-Feng Hong, Xiao-Ni Yan, Zhen-Hua Lu, Ying Fan, Fei Ye, Qiong Wu, Song-Hui Luo, Bo Yang, Jian-Jun Li
BACKGROUND: The relationship between non-fasting remnant cholesterol and cardiovascular outcome in the era of potent statin therapy remained to be elucidated. METHODS: A cohort study of three hundred and twenty eight diabetics diagnosed with new-onset stable coronary artery disease (CAD) by coronary angiography were enrolled. All cases were followed up for an average duration of twelve months. The association between baseline remnant cholesterol levels and major cardiovascular outcomes were evaluated using the receivers operating characteristic (ROC) curves and Cox proportional hazards regression analysis...
January 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28073900/the-longer-the-better-an-empirical-study-of-the-extent-and-mechanisms-of-attenuating-biomarker-associations-in-cardiovascular-patient-cohorts
#2
Lutz P Breitling, Ute Mons, Harry Hahmann, Wolfgang Koenig, Dietrich Rothenbacher, Hermann Brenner
BACKGROUND: Identifying novel risk markers in cardiovascular patients remains a research priority. Longer follow-up generally is considered favorable in such studies, but associations of interest may become attenuated with increasing follow-up. This issue has not been adequately addressed in the context of patient cohorts. The current study analyzed the extent and mechanisms of attenuating associations in a cardiovascular patient cohort. METHODS: The associations of numerous biomarkers with all-cause mortality were estimated by multiple Cox regression in the Langzeiterfolge der KARdiOLogischen Anschlussheilbehandlung (KAROLA) prospective cohort study of 1204 patients who had participated in an inpatient rehabilitation program after an acute coronary syndrome (ACS) or coronary bypass operation...
January 10, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28049676/power-of-peers-students-perceptions-of-pairing-in-clinical-dental-education
#3
Denise A Mills, Christine L Hammer, Aseel Murad
Prior studies have identified many benefits of peer mentoring in higher education, but the subject has not been widely examined in dental clinical education. Students at Midwestern University College of Dental Medicine-Arizona are paired with a partner for the duration of the clinical phase of education. The initial vision behind pairing was to train students in a realistic four-handed, efficient general practice model. The aim of this study was to assess the students' perceptions of the peer mentoring component of pairing third- and fourth-year dental students in the clinical phase of their education...
January 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28029445/dual-antagonism-of-pdgf-and-vegf-in-neovascular-age-related-macular-degeneration-a-phase-iib-multicenter-randomized-controlled-trial
#4
Glenn J Jaffe, Thomas A Ciulla, Antonio P Ciardella, Francois Devin, Pravin U Dugel, Chiara M Eandi, Harvey Masonson, Jordi Monés, Joel A Pearlman, Maddalena Quaranta-El Maftouhi, Federico Ricci, Keith Westby, Samir C Patel
PURPOSE: To assess the safety and efficacy of E10030 (Fovista; Ophthotech, New York, NY), a platelet-derived growth factor (PDGF) antagonist, administered in combination with the anti-vascular endothelial growth factor (VEGF) agent ranibizumab (Lucentis; Roche, Basel, Switzerland) compared with ranibizumab monotherapy in patients with neovascular age-related macular degeneration (nAMD). DESIGN: Phase IIb global, multicenter, randomized, prospective, double-masked, controlled superiority trial...
October 28, 2016: Ophthalmology
https://www.readbyqxmd.com/read/28019724/a-comparison-of-methods-to-estimate-anaerobic-capacity-accumulated-oxygen-deficit-and-w-during-constant-and-all-out-work-rate-profiles
#5
Daniel Muniz-Pumares, Charles Pedlar, Richard Godfrey, Mark Glaister
This study investigated (i) whether the accumulated oxygen deficit (AOD) and curvature constant of the power-duration relationship (W') are different during constant work-rate to exhaustion (CWR) and 3-min all-out (3MT) tests and (ii) the relationship between AOD and W' during CWR and 3MT. Twenty-one male cyclists (age: 40 ± 6 years; maximal oxygen uptake [V̇O2max]: 58 ± 7 ml · kg(-1) · min(-1)) completed preliminary tests to determine the V̇O2-power output relationship and V̇O2max. Subsequently, AOD and W' were determined as the difference between oxygen demand and oxygen uptake and work completed above critical power, respectively, in CWR and 3MT...
December 26, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27993483/lens-power-axial-length-to-corneal-radius-ratio-and-association-with-diabetic-retinopathy-in-the-adult-population-with%C3%A2-type-2-diabetes
#6
Jiangnan He, Xian Xu, Jianfeng Zhu, Bijun Zhu, Bo Zhang, Lina Lu, Xiangui He, Xuelin Bai, Xun Xu, Haidong Zou
PURPOSE: To calculate crystalline lens power and to determine the relationship between ocular biometry and diabetic retinopathy (DR) in an adult population with type 2 diabetes mellitus (T2DM). DESIGN: Cross-sectional, population-based study. PARTICIPANTS: Patients with T2DM from the Beixinjing community, Changning district, Shanghai. METHODS: Random clustering sampling was used to identify adults with T2DM in the Beixinjing community...
December 16, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27984792/collating-science-based-evidence-to-inform-public-opinion-on-the-environmental-effects-of-marine-drilling-platforms-in-the-mediterranean-sea
#7
REVIEW
M C Mangano, G Sarà
The use of rigorous methodologies to assess environmental, social and health impacts of specific interventions is crucial to disentangle the various components of environmental questions and to inform public opinion. The power of systematic maps relies on the capacity to summarise and organise the areas or relationships most studied, and to highlight key gaps in the evidence base. The recent Italian technical referendum (2016) - a public consultation inviting people to express their opinion by voting to change the rules on the length of licence duration and the decommissioning of offshore oil and gas platform drilling licences - inspired the creation of a systematic map of evidence to scope and quantify the effects of off-shore extraction platforms on Mediterranean marine ecosystems...
March 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/27982674/blood-pressure-and-hemodynamics-mayer-waves-in-different-phases-of-ovarian-and-menstrual-cycle-in-women
#8
O I Lutsenko, S O Kovalenko
The goal of the research is to investigate the special effect of ovarian-menstrual cycle phases on the level of women's blood pressure and characteristics of Mayer waves. 77 women aged 18-19 were tested under condition close to the state of basal metabolism in follicular phase (I), ovulation (II) and luteal phase (III) of ovarian-menstrual cycle. In phases II and III, the increase of mean and diastolic blood pressure level, in comparison with phase I in the prone position at rest and with psycho-emotional loading, were observed...
December 16, 2016: Physiological Research
https://www.readbyqxmd.com/read/27957244/neglected-features-of-lifestyle-their-relevance-in-non-alcoholic-fatty-liver-disease
#9
Francesca M Trovato, Giuseppe Fabio Martines, Daniela Brischetto, Guglielmo Trovato, Daniela Catalano
AIM: To investigated in non-alcoholic-fatty-liver-disease (NAFLD), with ultrasound (US)-detected fatty liver, and in a group of non-alcoholic and otherwise healthy subjects, relationship of neglected features of lifestyle with NAFLD and obesity. METHODS: Five hundred and thirty-two NAFLD and 667 non-NAFLD healthy subjects, age 21-60 years were studied. Severity of liver steatosis was assessed by US bright liver score. The adherence to mediterranean diet score (AMDS) was assessed on the basis of a 1-wk recall computerized questionnaire which included a detailed physical activity reports (Baecke questionnaire)...
November 28, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27938897/translating-clinical-findings-into-the-patient-s-perspective-post-hoc-pooled-analysis-of-bowel-movement-changes-as-a-predictor-of-improvement-in-patients-opioid-induced-constipation-symptoms-and-outcomes
#10
Karin S Coyne, Jiat-Ling Poon, Christine Thompson, Yiqun Hu, Catherine J Datto, Mark Sostek
PURPOSE: Opioid-induced constipation (OIC) is a bothersome side effect of opioid use for the management of noncancer pain, affecting patients' health-related quality of life and chronic-pain management. The objective of this study was to examine the relationship between changes in the frequency of spontaneous bowel movements (SBMs) and changes in patient-reported outcomes (PROs) among patients with OIC treated with naloxegol. METHODS: Post hoc analyses were conducted using pooled data from two Phase III 12-week, placebo-controlled trials of naloxegol for the treatment of OIC (NCT01309841 and NCT01323790)...
December 6, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27918961/the-promise-of-subtraction-ictal-spect-co-registered-to-mri-for-improved-seizure-localization-in-pediatric-epilepsies-affecting-factors-and-relationship-to-the-surgical-outcome
#11
Catherine Stamoulis, Nishant Verma, Himanshu Kaulas, Jonathan J Halford, Frank H Duffy, Phillip L Pearl, S Ted Treves
OBJECTIVE: Ictal SPECT is promising for accurate non-invasive localization of the epileptogenic brain tissue in focal epilepsies. However, high quality ictal scans require meticulous attention to the seizure onset. In a relatively large cohort of pediatric patients, this study investigated the impact of the timing of radiotracer injection, MRI findings and seizure characteristics on ictal SPECT localizations, and the relationship between concordance of ictal SPECT, scalp EEG and resected area with seizure freedom following epilepsy surgery...
November 30, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27918663/comparison-of-critical-power-and-w-derived-from-two-or-three-maximal-tests
#12
Len Parker Simpson, Mehdi Kordi
PURPOSE: Typically, accessing the asymptote (Critical Power; CP) and curvature constant (W') parameters of the hyperbolic power-duration relationship requires multiple constant-power, exhaustive exercise trials, spread over several visits. However, more recently single-visit protocols and personal power meters have been used. We investigated the practicality of using a two-trial, single-visit protocol in providing reliable CP & W' estimates. METHODS: 8 trained cyclists underwent 3- and 12-min maximal exercise trials in a single session to derive (2-trial) CP & W' estimates...
December 5, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27856712/rates-of-performance-loss-and-neuromuscular-activity-in-men-and-women-during-cycling-evidence-for-a-common-metabolic-basis-of-muscle-fatigue
#13
Christopher W Sundberg, Sandra K Hunter, Matthew W Bundle
The durations that muscular force and power outputs can be sustained until failure fall predictably on an exponential decline between an individual's 3-s burst maximum to the maximum performance they can sustain aerobically. The exponential time constants describing these rates of performance loss are similar across individuals suggesting that a common metabolically-based mechanism governs muscle fatigue; however, these conclusions come from studies mainly on men. To test whether the same physiological understanding can be applied to women, we compared the performance-duration relationships and neuromuscular activity between 7 men (23...
November 17, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27806677/power-duration-relationship-physiology-fatigue-and-the-limits-of-human-performance
#14
Mark Burnley, Andrew M Jones
The duration that exercise can be maintained decreases as the power requirements increase. In this review, we describe the power-duration (PD) relationship across the full range of attainable power outputs in humans. We show that a remarkably small range of power outputs is sustainable (power outputs below the critical power, CP). We also show that the origin of neuromuscular fatigue differs considerably depending on the exercise intensity domain in which exercise is performed. In the moderate domain (below the lactate threshold, LT), fatigue develops slowly and is predominantly of central origin (residing in the central nervous system)...
November 3, 2016: European Journal of Sport Science
https://www.readbyqxmd.com/read/27802372/preserving-self-medication-taking-practices-and-preferences-of-older-adults-with-multiple-chronic-medical-conditions
#15
Roxanne Vandermause, Joshua J Neumiller, Brian J Gates, Prabu David, Molly Altman, Daniel J Healey, Patricia Benson, Duane Sunwold, Gail Burton, Katherine R Tuttle, Cynthia F Corbett
PURPOSE: To examine the experiences of older adults with multiple chronic medical conditions when a new medication was added to their existing multiple medication regimen. DESIGN: A multimethod qualitative design was used. Thirty adults 60 years of age with (a) at least three chronic medical diagnoses, (b) at least five medications at baseline, and (c) a new medication prescription were enrolled in a prospective study of 30 days duration, participating from their homes...
November 2016: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/27787608/the-constant-work-rate-critical-power-protocol-overestimates-ramp-incremental-exercise-performance
#16
Matthew I Black, Andrew M Jones, James A Kelly, Stephen J Bailey, Anni Vanhatalo
PURPOSE: The parameters of the power-duration relationship (i.e., the critical power, CP, and the curvature constant, W') may theoretically predict maximal performance capability for exercise above the CP. The CP and W' are associated with the parameters of oxygen uptake ([Formula: see text]O2) kinetics, which can be altered by manipulation of the work-rate forcing function. We tested the hypothesis that the CP and W' derived from constant work-rate (CWR) prediction trials would overestimate ramp incremental exercise performance...
December 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27735982/temporal-organization-of-stride-duration-variability-as-a-marker-of-gait-instability-in-parkinson-s-disease
#17
Thibault Warlop, Christine Detrembleur, Benjamin Bollens, Gaëtan Stoquart, Frédéric Crevecoeur, Anne Jeanjean, Thierry M Lejeune
OBJECTIVE: Gait instability and fall risk are major concerns in Parkinson's disease. This study shows that the temporal organization of gait variability can represent a marker of gait instability that complements standard assessment of motor deficits in Parkinson's disease. METHODS: Temporal organization (long-range autocorrelation; LRA) of stride duration variability, collected from 20 persons with Parkinson's disease walking overground at a comfortable speed, was studied...
November 11, 2016: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27730072/study-of-vitamin-b12-deficiency-and-peripheral-neuropathy-in-metformin-treated-early-type-2-diabetes-mellitus
#18
Rudra Prasad Roy, Kaushik Ghosh, Manas Ghosh, Amitava Acharyya, Ambarish Bhattacharya, Mrinal Pal, Sisir Chakraborty, Nilanjan Sengupta
BACKGROUND: Long-term therapy with metformin was shown to decrease the Vitamin B12 level and manifested as peripheral neuropathy. AIM: The aim of this study is to define the prevalence of Vitamin B12 deficiency in early Type 2 diabetic patients (duration ≤5 years or drug treatment ≤3 years) and the relationship among metformin exposure and levels of cobalamin (Cbl), folic acid, and homocysteine (Hcy) with severity of peripheral neuropathy. METHODOLOGY: This is a cross-sectional study involving randomly selected ninety patients (male 56, female 34) between age groups of 35 and 70 years, comparing those who had received >6 months of metformin (Group A) (n = 35) with those without metformin (Group B) (n = 35) and patients taking metformin with other oral hypoglycemic agent (Group C) (n = 20)...
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27703445/asking-new-questions-with-old-data-the-centralized-open-access-rehabilitation-database-for-stroke
#19
Keith R Lohse, Sydney Y Schaefer, Adam C Raikes, Lara A Boyd, Catherine E Lang
BACKGROUND: This paper introduces a tool for streamlining data integration in rehabilitation science, the Centralized Open-Access Rehabilitation database for Stroke (SCOAR), which allows researchers to quickly visualize relationships among variables, efficiently share data, generate hypotheses, and enhance clinical trial design. METHODS: Bibliographic databases were searched according to inclusion criteria leaving 2,892 titles that were further screened to 514 manuscripts to be screened by full text, leaving 215 randomized controlled trials (RCTs) in the database (489 independent groups representing 12,847 patients)...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27688431/w-expenditure-and-reconstitution-during-severe-intensity-constant-power-exercise-mechanistic-insight-into-the-determinants-of-w
#20
Ryan M Broxterman, Phillip F Skiba, Jesse C Craig, Samuel L Wilcox, Carl J Ade, Thomas J Barstow
The sustainable duration of severe intensity exercise is well-predicted by critical power (CP) and the curvature constant (W'). The development of the W'BAL model allows for the pattern of W' expenditure and reconstitution to be characterized and this model has been applied to intermittent exercise protocols. The purpose of this investigation was to assess the influence of relaxation phase duration and exercise intensity on W' reconstitution during dynamic constant power severe intensity exercise. Six men (24...
October 2016: Physiological Reports
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