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Sperm apoptosis

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https://www.readbyqxmd.com/read/27905126/ameliorating-effects-of-fennel-and-cumin-extracts-on-sperm-quality-and-spermatogenic-cells-apoptosis-by-inducing-weight-loss-and-reducing-leptin-concentration-in-diet-induced-obese-rats
#1
R Nejatbakhsh, S Riyahi, A Farrokhi, S Rostamkhani, S Mahmazi, A Yazdinezhad, M Kazemi, S Shokri
This study was established a model of obesity to estimate the impact of fennel and cumin as anti-obesity extracts on body weight, body mass index (BMI), food consumption, leptin concentration, sperm quality and testis architecture to determine the reversibility of reproductive function of obese animals. Male rats were randomly assigned to either a normal or high-fat diet for 8 weeks. Then, we divided 56 adult rats into seven groups: control (CO); obesity (OB); fennel 100 and 200 mg/kg; cumin 50 and 100 mg/kg; and fennel 100 mg/kg plus cumin 50 mg/kg...
November 30, 2016: Andrologia
https://www.readbyqxmd.com/read/27894913/the-regulation-of-cellular-apoptosis-by-the-ros-triggered-perk-eif2%C3%AE-chop-pathway-plays-a-vital-role-in-bisphenol-a-induced-male-reproductive-toxicity
#2
Li Yin, Yanlin Dai, Zhihong Cui, Xiao Jiang, Wenbin Liu, Fei Han, Ao Lin, Jia Cao, Jinyi Liu
Bisphenol A (2,2-bis(4-hydroxyphenyl)propane, BPA) is ubiquitous in the environment, wildlife, and humans. Evidence from past studies suggests that BPA is associated with decreased semen quality. However, the molecular basis for the adverse effect of BPA on male reproductive toxicity remains unclear. We evaluated the effects of BPA on mouse spermatocytes GC-2 cells and adult mice, and we explored the potential mechanism of its action. The results showed that BPA inhibited cell proliferation and increased the apoptosis rate...
November 25, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27892789/4-vinylcyclohexene-diepoxide-disrupts-sperm-characteristics-endocrine-balance-and-redox-status-in-testes-and-epididymis-of-rats
#3
Isaac A Adedara, Amos O Abolaji, Emmanuel O Ladipo, Ore J Fatunmibi, Ayodeji O Abajingin, Ebenezer O Farombi
OBJECTIVES: Exposure to 4-vinylcyclohexene diepoxide (VCD) was reported to induce testicular germ cell toxicity in rodents. However, there is paucity of information on the precise biochemical and molecular mechanisms of VCD-induced male reproductive toxicity. METHODOLOGY: This study investigated the influence of VCD on testicular and epidydimal functions following oral exposure of Wistar rats to VCD at 0, 100, 250 and 500 mg/kg for 28 consecutive days. RESULTS: Administration of VCD significantly decreased the body weight gain and organo-somatic indices of the testes and epididymis...
November 28, 2016: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27882589/attenuation-of-the-cyproterone-acetate-induced-testicular-hypofunction-by-a-novel-nutraceutical-lycopene-a-genomic-approach
#4
A Tripathy, A Ghosh, A Dey, B P Pakhira, D Ghosh
This study was designed to explore the cyproterone acetate (CPA)-induced andrological hypofunction and its correction by oral administration of lycopene. In this concern, spermatogenic, biochemical, histological and genomic profiles were studied. Cyproterone acetate administration for 1 month helped to develop infertile model rats. A significant recovery was noted in sperm motility, sperm count, sperm viability, hypo-osmotic swelling tail-coiled spermatozoa; activities of testicular ∆(5) , 3β-hydroxysteroid dehydrogenase (HSD), 17β-HSD, catalase (CAT) and superoxide dismutase (SOD); and levels of conjugated diene (CD), malondialdehyde (MDA), testicular cholesterol and serum testosterone after the administration of lycopene at 1...
November 24, 2016: Andrologia
https://www.readbyqxmd.com/read/27865410/comparative-analysis-of-testis-transcriptomes-associated-with-male-infertility-in-cattleyak
#5
Xin Cai, Shumin Yu, TserangDonko Mipam, Fang Yang, Wangsheng Zhao, Wenjing Liu, SuiZhong Cao, Liuhong Shen, Fangfang Zhao, Lei Sun, Chuanfei Xu, Shixin Wu
Cattleyak exhibit equivalent adaptability to harsh environment as yak and much higher performances than yak. However, male infertility of cattleyak due to spermatogenic arrest greatly restricts their effective utilization in yak breeding. Although much work has been done to investigate the mechanisms of spermatogenic arrest, there is little information available in regard to the differences in transcriptomic profiling between cattleyak and yak testes. In this work, histologic observation indicated that spermatogonia were the main type of germ cells present in cattleyak testis, whereas all types of germ cells in differentiation were present in yak testis...
January 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/27855185/aberrant-expression-of-timp-2-and-pbef-genes-in-the-placentae-of-cloned-mice-due-to-epigenetic-reprogramming-error
#6
Hong Rye Kim, Jae Eun Lee, Reza Kheirkhahi Oqani, So Yeon Kim, Teruhiko Wakayama, Chong Li, Su Jin Sa, Je Seok Woo, Dong Il Jin
Cloned mice derived from somatic or ES cells show placental overgrowth (placentomegaly) at term. We had previously analyzed cloned and normal mouse placentae by using two-dimensional gel electrophoresis and mass spectrometry to identify differential protein expression patterns. Cloned placentae showed upregulation of tissue inhibitor of metalloproteinase-2 (TIMP-2), which is involved in extracellular matrix degradation and tissue remodeling, and downregulation of pre-B cell colony enhancing factor 1 (PBEF), which inhibits apoptosis and induces spontaneous labor...
2016: PloS One
https://www.readbyqxmd.com/read/27853306/osr1-and-spak-cooperatively-modulate-sertoli-cell-support-of-mouse-spermatogenesis
#7
Yung-Liang Liu, Sung-Sen Yang, Shyi-Jou Chen, Yu-Chun Lin, Chin-Chen Chu, Hsin-Hui Huang, Fung-Wei Chang, Mu-Hsien Yu, Shih-Hua Lin, Gwo-Jang Wu, Huey-Kang Sytwu
We investigated the role of oxidative stress-responsive kinase-1 (OSR1) and STE20 (sterile 20)/SPS1-related proline/alanine-rich kinase (SPAK), upstream regulators of the Na(+)-K(+)-2Cl(-) cotransporter (NKCC1)-essential for spermatogenesis-in mouse models of male fertility. Global OSR1(+/-) gene mutations, but not global SPAK(-/-) or Sertoli cell (SC)-specific OSR1 gene knockout (SC-OSR1(-/-)), cause subfertility with impaired sperm function and are associated with reduced abundance of phosphorylated (p)-NKCC1 but increased p-SPAK expression in testicular tissue and spermatozoa...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27832966/nonylphenol-induced-apoptosis-and-autophagy-involving-the-akt-mtor-pathway-in-prepubertal-sprague-dawley-male-rats-in-vivo-and-in-vitro
#8
Wenting Huang, Chao Quan, Peng Duan, Sha Tang, Wei Chen, Kedi Yang
This research explores the detrimental effect of nonylphenol (NP) to prepubertal Sprague-Dawley male rats in vivo and in vitro. Herein, forty-two 3-week-old rats were randomly divided into six groups, which were treated with NP (0, NAC, 25, 50, 100, 100+NACmg/kg/2d for 30 consecutive days) by intraperitoneal injection. NP induced a reduction in testosterone (15.58%, 17.23%, 13.38% in 25, 50, 100mg/kg group, respectively), triggered apoptosis related to oxidative stress, and disturbed mRNA and/or protein levels of PI3K, PTEN, PDK1, p-Akt, p-mTOR, p70S6K, caspase-3, LC3B...
November 8, 2016: Toxicology
https://www.readbyqxmd.com/read/27819720/male-idiopathic-infertility-and-the-tp53-polymorphism-in-codon-72
#9
M P de Morais, R F Curado, K S F E Silva, K K V O Moura, J T Arruda
Many environmental agents affect the development of male germ cells at different stages. Apoptosis is common during normal spermatogenesis; it plays an important role in controlling the number of germ cells and the disposal of defective stem cells to produce functional sperm. The presence of p53 in primary spermatocytes suggests that it plays a role in the prophase of meiosis. p53 is expressed in the testis in both spermatocytes and spermatogonia. This suggests that the p53 gene (TP53) is important for apoptosis regulation during spermatogenesis, and may be associated with male infertility...
November 3, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27806317/resveratrol-changes-spermatogonial-stem-cells-sscs-activity-and-ameliorates-their-loss-in-busulfan-induced-infertile-mouse
#10
Chongyang Wu, Ying Zhang, Qiaoyan Shen, Zhe Zhou, Weishuai Liu, Jinlian Hua
The decline of quantity and quality of sperm are correlated with the increasing age and some anti-cancer compounds such as busulfan. Previous studies have shown that Resveratrol (Res) inhibits tumorigenesis and metastasis of many cancers including mammary tumor, prostate and pancreatic cancers. It acts as anti-age in mouse and human, however, little is known about its protective effect on aged spermatogonial stem cells (SSCs). Here, we investigated the effects of Res in vitro on SSCs usingC18-4 cells and in vivo in busulfan-induced azoospermia mice model...
October 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27802063/in-silico-analysis-of-candidate-proteins-sharing-homology-with-streptococcus-agalactiae-proteins-and-their-role-in-male-infertility
#11
Rajeshwari Parida, Luna Samanta
: Leukocytospermia is a physiologic condition defined as human semen with a leukocyte count of >1 x 10(6) cells/ml that is often correlated with male infertility. Moreover, bacteriospermia has been associated with leukocytospermia ultimately leading to male infertility. We have found that semen samples with >1 x 10(6)/ml leukocytes and/or bacteriospermia have oxidative predominance as evidenced by augmented protein carbonyl and lipid peroxidation status of the semen which is implicated in sperm dysfunction...
November 1, 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27793655/infectious-burden-and-semen-parameters
#12
E Moretti, N Figura, M S Campagna, F Iacoponi, S Gonnelli, G Collodel
OBJECTIVES: To investigate the relationship between chronic infections detected in serum and semen quality. The pathogen burden is a concept consisting in the observation that, in patients with heart disease, damaging effects of the coronary arteries increase concomitantly with the number of agents responsible of chronic infections to which patients mounted a serological response. Previous observations that H. pylori infection may reduce the semen quality prompted us to perform the present study...
October 25, 2016: Urology
https://www.readbyqxmd.com/read/27789183/expression-of-ndufa13-in-asthenozoospermia-and-possible-pathogenesis
#13
Yang Yang, Laiyang Cheng, Ying Wang, Yilong Han, Jin Liu, Xiaohui Deng, Lan Chao
Asthenozoospermia is a common cause of male infertility, which is characterized by reduced forward motility of spermatozoa. The cause and pathogenesis of asthenozoospermia are not fully understood. The purpose of this study was to investigate the expression of nicotinamide adenine dinucleotide (NADH) dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 (NDUFA13) in the spermatozoa of men with asthenozoospermia and its possible pathogenesis. Protein content of NDUFA13 in spermatozoa was measured by Western blot analysis...
October 14, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27785022/cytotoxic-effects-of-zno-nanoparticles-on-mouse-testicular-cells
#14
Zhe Han, Qi Yan, Wei Ge, Zhi-Guo Liu, Sangiliyandi Gurunathan, Massimo De Felici, Wei Shen, Xi-Feng Zhang
BACKGROUND: Nanoscience and nanotechnology are developing rapidly, and the applications of nanoparticles (NPs) have been found in several fields. At present, NPs are widely used in traditional consumer and industrial products, however, the properties and safety of NPs are still unclear and there are concerns about their potential environmental and health effects. The aim of the present study was to investigate the potential toxicity of ZnO NPs on testicular cells using both in vitro and in vivo systems in a mouse experimental model...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27780264/ubiquitin-carboxy-terminal-hydrolasel3-correlates-with-human-sperm-count-motility-and-fertilization
#15
Meijiao Wang, Tinghe Yu, Lina Hu, Zhi Cheng, Min Li
Ubiquitin C-terminal hydrolase L3 (UCHL3) belongs to the group of deubiquitinating enzymes and plays a part in apoptosis of germ cells and the differentiation of spermatocytes into spermatids. However, the exact role of UCHL3 in human spermatogenesis and sperm function remains unknown. Here we examined the level and activity of UCHL3 in spermatozoa from men with asthenozoospermia (A), oligoasthenozoospermia (OA) or normozoospermia (N). Immunofluorescence indicated that UCHL3 was mainly localized in the acrosome and throughout the flagella, and western blotting revealed a lower level in A or OA compared with N (p < 0...
2016: PloS One
https://www.readbyqxmd.com/read/27779666/effects-of-the-igf-1-pten-akt-foxo-signaling-pathway-on-male-reproduction-in-rats-subjected-to-water-immersion-and-restraint-stress
#16
Pan Huang, Zhengrong Zhou, Fangxiong Shi, Genbao Shao, Ran Wang, Jintian Wang, Kangxin Wang, Wei Ding
The aim of the present study was to determine the effects of the insulin-like growth factor 1 (IGF-1)/phosphatase and tensin homologue deleted on chromosome 10 (PTEN)/Akt/forkhead box (FoxO) signaling pathway on male reproduction in rats subjected to water immersion and restraint stress (WRS). Sperm morphology, sperm malformation rate, and serum testosterone concentration were analyzed following WRS. In addition, the expression levels and immunolocalization of IGF‑1, PTEN, Akt and FoxO proteins, as well as the rate of cell apoptosis in rat testes, were investigated...
October 24, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27762473/oxidative-damage-of-the-male-reproductive-system-induced-by-paraquat
#17
Qing Chen, Xin Zhang, Jin-Yan Zhao, Xiao-Ning Lu, Peng-Sheng Zheng, Xiang Xue
The effects of paraquat (PQ) on the male reproductive system are unclear. In this study, male rats were divided into four groups (0, 0.5, 2, and 8 mg/kg) and treated with PQ by oral gavage for 8 weeks. At the end of the experiment, a significant decline in sperm count, motility, and viability and an increase in teratospermia were observed in the PQ-treated group (P < 0.05). Further investigation found that PQ resulted in enhanced lipid peroxidation and more apoptosis in the testis tissues, and apoptosis was likely to be associated with activation of the mitochondrial pathway...
October 20, 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/27761864/proanthocyanidin-protects-against-acute-zearalenone-induced-testicular-oxidative-damage-in-male-mice
#18
Miao Long, Shuhua Yang, Yi Zhang, Peng Li, Jianxin Han, Shuang Dong, Xinliang Chen, Jianbin He
Zearalenone (ZEN) exerts a major effect on human and animal health and has led to serious worldwide economic problems. In this study, we investigated whether proanthocyanidin (PC) can prevent ZEN-induced testicular oxidative damage in male mice and explored the underlying mechanism. Kunming mice were injected with ZEN (40 mg kg(-1)) on the 11th day after intragastric administration of PC (75 or 150 mg/kg) for 10 days; the sperm quality of mice was then analysed statistically. Additionally, testicular morphology parameters related to oxidative damage, apoptosis and the expression of endoplasmic reticulum (ER) stress-related genes (GRP78, CHOP and XBP-1) were all measured...
October 19, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27750479/changes-in-gene-expression-and-metabolism-in-the-testes-of-the-rat-following-spinal-cord-injury
#19
Ryan D Fortune, Raymond J Grill, Christine Beeton, Mark Tanner, Redwan Huq, David S Loose
Spinal cord injury (SCI) results in devastating changes to almost all aspects of a patient's life. In addition to a permanent loss of sensory and motor function, males also will frequently exhibit a profound loss of fertility through poorly understood mechanisms. We demonstrate that SCI causes measureable pathology in the testis both acutely (24 h) and chronically up to 1.5 years post-injury, leading to loss in sperm motility and viability. SCI has been shown in humans and rats to induce leukocytospermia, with the presence of inflammatory cytokines, anti-sperm antibodies, and reactive oxygen species found within the ejaculate...
December 2, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27748829/protective-effect-of-resveratrol-on-spermatozoa-function-in-male-infertility-induced-by-excess-weight-and-obesity
#20
Xiangrong Cui, Xuan Jing, Xueqing Wu, Meiqin Yan
Male infertility is a complex, multifactorial and polygenic disease that contributes to ~50% cases of infertility. Previous studies have demonstrated that excess weight and obesity factors serve an important role in the development of male infertility. An increasing number of studies have reported that resveratrol may regulate the response of cells to specific stimuli that induce cell injury, as well as decrease germ cell apoptosis in mice or rats. In the present study, the semen quality and serum sex hormone levels were evaluated in 324 men, which included 73 underweight, 82 normal weight, 95 overweight and 74 obese men...
November 2016: Molecular Medicine Reports
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