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https://www.readbyqxmd.com/read/28221760/hydrogel-nanocomposites-with-independently-tunable-rheology-and-mechanics
#1
Shimon Unterman, Lyndon F Charles, Sara E Strecker, Denis Kramarenko, Dmitry Pivovarchik, Elazer Reuven Edelman, Natalie Artzi
Hydrogels are an attractive class of biomaterials for minimally invasive local drug delivery given their injectability, tunability, high water content, and biocompatibility. Broad applicability though is challenged: relatively modest mechanical properties restricts use to soft tissues, while flow properties necessary for injectability limit implantation to dried, enclosed tissues to minimize material migration during gelation. To address these dual concerns we designed an injectable nanocomposite hydrogel based on dextran aldehyde and poly(amido amine) dendrimer doped with phyllosilicate nanoplatelet fillers...
February 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28210379/two-crosslinking-technologies-for-superficial-reticular-dermis-injection-a-comparative-ultrasound-and-histologic-study
#2
Patrick Micheels, Stéphanie Besse, Didier Sarazin
Background: Few hyaluronic acid fillers have been developed for superficial injection. Objective: To compare the diffusion and integration properties of cohesive polydensified matrix and Vycross® technology hyaluronic acid fillers with lidocaine following injection into the superficial reticular dermis. Methods and materials: Two subjects received two injections each of cohesive polydensified matrix and Vycross® hyaluronic acid (0.2mL/site) in the superficial reticular dermis of the buttock under ultrasound control...
January 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28203492/safety-and-effectiveness-of-juv%C3%A3-derm-ultra-plus-injectable-gel-in-correcting-severe-nasolabial-folds-in-chinese-subjects
#3
Dong Li, Yun Xie, Qin Li, Jiaming Sun, Ping Jiang, Yi Jia, Diane K Murphy, Qingfeng Li
BACKGROUND: Hyaluronic acid dermal fillers are effective in correcting severe nasolabial folds (NLFs) in non-Asian populations. We assessed safety and effectiveness of Juvéderm Ultra Plus in a Chinese population. METHODS: This double-blind study randomized Chinese subjects with severe NLFs to Juvéderm Ultra Plus (24 mg/mL) in 1 NLF and Restylane injectable gel (20 mg/mL) in the other NLF. NLFs were evaluated using the validated 5-point photonumeric Allergan NLF Severity Scale (0 is "no wrinkle" and 4 is "very deep wrinkle")...
January 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28181101/preparation-of-hydroxyapatite-collagen-injectable-bone-paste-with-an-anti-washout-property-utilizing-sodium-alginate-part-1-influences-of-excess-supplementation-of-calcium-compounds
#4
Taira Sato, Masanori Kikuchi, Mamoru Aizawa
The anti-washout property, viscosity, and cytocompatibility to an osteoblastic cell line, MG-63, of anti-washout pastes were investigated. Mixing a hydroxyapatite/collagen bone-like nanocomposite (HAp/Col), an aqueous solution of sodium alginate (Na-Alg), which is a paste hardening and lubricant agent, and supplementation of calcium carbonate or calcium citrate (Ca-Cit) as a calcium resource for the hardening reaction realized an injectable bone paste. Adding Ca-Cit at a concentration greater than eight times the Ca(2+) ion concentration to Na-Alg improved the anti-washout property...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28178006/prostaglandin-injection-after-arterial-compromise-related-to-hyaluronic-acid-filler
#5
Juan Eduardo Megías-Vericat, José María Ricart, Hugo Ribes-Artero, José Luis Poveda
No abstract text is available yet for this article.
February 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28165349/a-prospective-open-label-observational-postmarket-study-evaluating-vyc-17-5l-for-the-correction-of-moderate-to-severe-nasolabial-folds-over-12-months
#6
Gerhard Sattler, Wolfgang G Philipp-Dormston, Helga Van Den Elzen, Cornelius Van Der Walt, Myooran Nathan, Julia Kolodziejczyk, Graeme Kerson, Benjeev Dhillon
BACKGROUND: VYC-17.5L (17.5 mg/mL hyaluronic acid, 0.3% lidocaine) is a dermal filler intended for deep dermis injection for the treatment of skin depressions. OBJECTIVE: To evaluate 12-month effectiveness and safety of VYC-17.5L for the treatment of moderate/severe nasolabial folds (NLFs). METHODS: Subjects ≥18 years old with moderate/severe NLFs were recruited (N = 70). Injected volume was aimed at achieving optimum correction; top-up treatment was given at 2 weeks if needed...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28157728/safety-and-effectiveness-of-vyc-15l-a-hyaluronic-acid-filler-for-lip-and-perioral-enhancement-one-year-results-from-a-randomized-controlled-study
#7
Roy G Geronemus, David E Bank, Bhushan Hardas, Ava Shamban, Barry M Weichman, Diane K Murphy
BACKGROUND: VYC-15L (Juvéderm Volbella XC) is a nonanimal crosslinked hyaluronic acid (HA) gel with lidocaine. OBJECTIVE: To evaluate the safety and effectiveness of VYC-15L for lip and perioral enhancement versus a nonanimal stabilized HA with lidocaine (Restylane-L; NASHA). METHODS: This prospective multicenter study randomized 225 adults with minimal, mild, or moderate lip fullness on the validated 5-point Allergan Lip Fullness Scale (LFS) to treatment with VYC-15L or NASHA; optional touch-up was administered 30 days later...
February 1, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28157719/preclinical-safety-and-efficacy-evaluation-of-biocas-bioactive-calcium-sulfate-bone-cement
#8
Sony Sandhya, Parayanthala Valappil Mohanan, Arumugan Sabareeswaran, Hari Krishna Varma, Manoj Komath
A new bioactive calcium sulfate-based formulation (named 'BioCaS') has been developed for bone filler applications. This is a self-setting injectable cement where the preset form comprises bassanite obtained from the uniform submicron-sized precursor crystals of gypsum, modified with hydrogen orthophosphate ions. The results of the safety and efficacy evaluation of BioCaS cement, done as per the International Standards and guidelines, are presented in this paper. The study plan consisted of in vitro screening tests of cytotoxicity and haemolysis and in vivo biocompatibility evaluation, including an acute systemic toxicity test (in mice), an intracutaneous reactivity test (in rabbits), a pyrogen test (in rabbits) and a maximization sensitization test (in guinea pigs)...
February 3, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28145073/a-multicenter-randomized-double-blind-clinical-study-to-evaluate-the-efficacy-and-safety-of-a-new-monophasic-hyaluronic-acid-filler-with-lidocaine-0-3-in-the-correction-of-nasolabial-fold
#9
Joon Hyuk Suh, Chang Taek Oh, Song I Im, Jung Soo Lim, Beom Joon Kim, Jong Hun Lee
BACKGROUND: Many new brands of hyaluronic acid (HA) fillers are being introduced, but comparative research on the characteristics of similar products is limited. OBJECTIVE: To test the efficacy, tolerability, and safety of a HA filler with lidocaine, Dermalax implant plus™ (Across), which is used for correcting nasolabial folds (NLFs), and to compare the performance of that of Restylane Sub-Q(®) (Q-Med). METHODS: A total of 52 subjects with visible NLFs were enrolled in this randomized, multicenter, patient/evaluator-blind, active-controlled, matched-pair clinical study...
February 1, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28135883/efficacy-and-durability-of-hyaluronic-acid-fillers-for-malar-enhancement-a-prospective-randomized-spilt-face-clinical-controlled-trial
#10
Ki Heon Jeong, Min Jae Gwak, Sung Kyung Moon, Sang Jun Lee, Min Kyung Shin
Various hyaluronic acid fillers can be used for facial attenuation and rejuvenation. The efficacy and durability of hyaluronic acid fillers are of major concern to dermatologists and patients. This study aimed to evaluate three dimensional morphology, tissue distribution, and changes in volume after injection of two different hyaluronic acid fillers. Ten Korean women were enrolled in this study. Each subject was injected with monophasic hyaluronic acid filler in one malar area and biphasic filler in the other...
January 31, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28130558/delayed-onset-edematous-foreign-body-granulomas-40%C3%A2-years-after-augmentation-rhinoplasty-by-silicone-implant-combined-with-liquid-silicone-injection
#11
Hao-Chun Hu, Hsu-Wei Fang, Yu-Hsun Chiu
: Despite the widespread application of augmentation rhinoplasty in Asia, reports on the interaction between alloplastic implants and injectable filler are scarce. This paper reports on a patient with delayed-onset edematous foreign body granuloma that had been caused by augmentation rhinoplasty performed using a silicone implant in conjunction with a liquid silicone injection 40 years earlier. This is the longest reported duration between initial rhinoplasty and the exacerbation of foreign body granuloma...
January 27, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28121721/chronic-eyelid-edema-following-periocular-hyaluronic-acid-filler-treatment
#12
Jonathan T S Yu, Liam Peng, Sajid Ataullah
A 54-year-old woman received multiple injections of hyaluronic acid filler to the brow region to address volume loss over a 21-month period. She then developed significant pitting edema of both upper eyelids, which persisted for 6 years. Hyaluronidase (Hyalase) was injected into the subcutaneous brows and resulted in complete resolution of the edema within 2 days. This confirms that the hyaluronic acid injected into the brows was responsible for this patient's chronic eyelid edema. This case illustrates an unusual long-term complication of periocular hyaluronic acid filler...
January 23, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28121477/tear-trough-rejuvenation-a-safety-evaluation-of-the-treatment-by-a-semi-cross-linked-hyaluronic-acid-filler
#13
Marouen Berguiga, Olivier Galatoire
The aim of this study is to describe the experience of 33 physicians, dermatologists and surgeons, with the use of a semi-cross-linked hyaluronic acid (HA) gel as a tear trough deformity filler within one month following injection, and to assess patient satisfaction with the procedure. This study is a case series conducted between February 2012 and December 2012 with the use of semi-cross-linked HA to correct tear trough deformity. The filler was administered in the preperiosteal tissues. The study involved case note review and a patient satisfaction survey...
January 25, 2017: Orbit
https://www.readbyqxmd.com/read/28096117/commentary-on-an-anatomical-analysis-of-the-supratrochlear-artery-considerations-in-facial-filler-injections-and-preventing-vision-loss
#14
Ramin Fathi, Brian Biesman, Joel L Cohen
No abstract text is available yet for this article.
February 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28095576/facial-contouring-with-fillers-neuromodulators-and-lipolysis-to-achieve-a-natural-look-in-patients-with-facial-fullness
#15
Chytra Anand
BACKGROUND: The desire for and use of nonsurgical injectable esthetic facial treatments is on a rise in Asia. Recent advances, including more versatile facial fillers, refined injection techniques, and adoption of a global facial approach, have in turn contributed to improved patient outcomes and increased patient satisfaction. The sought after nonsurgical treatments include the use of botulinum toxin, con- touring of the face with soft tissue fillers, and thinning of the face with injection lipolysis...
December 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095575/review-of-periorbital-and-upper-face-pertinent-anatomy-aging-injection-techniques-prevention-and-management-of-complications-of-facial-fillers
#16
Julie Woodward
This paper aims to review articles related to facial fillers in the periorbital area, forehead, and temple. Anatomy, anatomical changes with aging, techniques of rejuvenation and facial harmonization with fillers are reviewed. Topics for complication prevention and management including knowledge of danger zones, timing of hyaluronidase injections, aspiration, definition a small aliquot, and thoughts about particle size are discussed. J Drugs Dermatol. 2016;15(12):1524-1531.
December 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28045813/b-cell-lymphoma-in-a-patient-with-a-history-of-foreign-body-injection
#17
Seo Hyung Lee, Hyun Chul Kim, Yu Jin Kim
Dermal filler injection has been one of the most evolving areas of interest in the field of esthetic plastic surgery. This procedure is sometimes preferred to surgery due to shorter procedure and patient recovery times, and because it is suitable for a wide range of applications. Dermal filler injection is considered to be relatively safe, but various late complications such as infection and foreign body granuloma sometimes occur. Postprocedure development of lymphoma also occurs, but is extremely rare. The authors diagnosed extranodal marginal zone B-cell lymphoma of the mucosa associated lymphoid tissue that developed after a filler injection procedure was performed on a patient's face...
December 30, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28032177/clinical-application-of-earlobe-augmentation-with-hyaluronic-acid-filler-in-the-chinese-population
#18
Wei Qian, Yan-Kun Zhang, Qian Cao, Ying Hou, Wei Lv, Ju-Feng Fan
BACKGROUND: Larger earlobes, which are a symbol of "richness" in traditional Chinese culture, are favored by Chinese patients. The objective of this paper is to investigate the application of earlobe augmentation with hyaluronic acid (HA) filler injection and its clinical effects in the Chinese population. METHODS: A total of 19 patients (38 ears) who received earlobe augmentation with HA filler injections between March 2013 and March 2015 were included. The clinical effects, duration, and complications of these cases were investigated...
December 28, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28032168/the-efficacy-and-safety-of-ha-idf-plus-with-lidocaine-versus-ha-idf-without-lidocaine-in-nasolabial-folds-injection-a-randomized-multicenter-double-blind-split-face-study
#19
Jong-Hun Lee, Seok-Hwan Kim, Eun-Soo Park
BACKGROUND: Injection-related pain of dermal fillers is a consistent and bothersome problem for patients undergoing soft tissue augmentation. Reducing the pain could improve overall patient satisfaction. OBJECTIVE: The purpose of this study was to compare the pain relief, efficacy, and safety of HA IDF plus containing lidocaine with HA IDF without lidocaine during correction of nasolabial folds (NLFs). METHODS: Sixty-two subjects were enrolled in a randomized, multicenter, double-blind, split-face study of HA IDF plus and HA IDF for NLF correction...
December 28, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28032167/facing-the-worst-risk-confronting-the-dorsal-nasal-artery-implication-for-non-surgical-procedures-of-nasal-augmentation
#20
Tanvaa Tansatit, Prawit Apinuntrum, Thavorn Phetudom
BACKGROUND: The nose is a dangerous site for filler injection. This study investigated the anatomy of the dorsal nasal artery at the upper part of the nose to clarify how ocular complications occur. METHODS: Dissections were performed in 50 noses of the embalmed cadavers. Either the soft embalming or formaldehyde embalming processes were used. RESULTS: The dorsal nasal artery is not a constant artery. The artery traveled in the subcutaneous tissue layer of the nasal dorsum on the transverse nasalis muscle and its midline nasal aponeurosis which connected the muscles on both sides...
December 28, 2016: Aesthetic Plastic Surgery
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