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https://www.readbyqxmd.com/read/28931769/evaluation-of-early-phase-biodistribution-in-123-i-ioflupane-spect
#1
Masaki Takahashi, Shoichi Toki, Yukitaka Yamashita, Akihiro Kaneko
It is reported that pharmacokinetics after intravenous injection of (123)I-ioflupane may reflect cerebral blood flow. In this study, the early-phase pharmacokinetics of (123)I-ioflupane in 10 healthy volunteers was analyzed over time using dynamic single-photon emission computed tomography (SPECT) immediately after intravenous injection. We also examined the correlation between the (123)I-IMP imaging and the (123)I-ioflupane early-phase image for 14 cases in which both dopamine transporter (DaT) imaging by (123)I-ioflupane and cerebral blood flow imaging by (123)I-IMP were performed on the same camera...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/28926150/facilitation-of-child-health-research-in-hospital-settings-the-views-of-nurses
#2
J Brown, O Barr, M Lindsay, E Ennis, S O'Neill
BACKGROUND: Child health research in clinical practice is increasing throughout the UK. Nurses and midwives facilitate access to patients, enact research study protocols and have a critical role in parental decisions to enrol children into research studies. Little is known about their perception of this process. AIMS & OBJECTIVES: To explore the views of nurses towards child health research and to identify factors influencing their willingness to facilitate it in practice...
September 19, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28923161/comparing-the-cognitive-process-of-circular-causality-in-two-patients-with-strokes-through-qualitative-analysis
#3
Seyed Alireza Derakhshanrad, Emily Piven, Bahareh Zeynalzadeh Ghoochani
Walter J. Freeman pioneered the neurodynamic model of brain activity when he described the brain dynamics for cognitive information transfer as the process of circular causality at intention, meaning, and perception (IMP) levels. This view contributed substantially to establishment of the Intention, Meaning, and Perception Model of Neuro-occupation in occupational therapy. As described by the model, IMP levels are three components of the brain dynamics system, with nonlinear connections that enable cognitive function to be processed in a circular causality fashion, known as Cognitive Process of Circular Causality (CPCC)...
October 2017: Nonlinear Dynamics, Psychology, and Life Sciences
https://www.readbyqxmd.com/read/28921671/methyl-jasmonate-ameliorates-unpredictable-chronic-mild-stress-induced-behavioral-and-biochemical-alterations-in-mouse-brain
#4
Adaeze Adebesin, Abayomi M Ajayi, Elizabeth O Olonode, Osarume Omorogbe, Solomon Umukoro
Preclinical Research The effects of methyl jasmonate (MJ; 5, 10, 20 mg/kg, i.p), a natural product widely used for the relief of stress, depression, and exhaustion on unpredictable chronic mild stress (UCMS)-induced depression-like behaviors in mice was assessed and compared to those of imipramine (IMP; 10 mg/kg, i.p). MJ and IMP were given 30 min before exposure to UCMS with the procedure repeated daily for 2 weeks; 24 h after the stress session, the tail suspension test (TST) and sucrose preference test were assessed...
September 17, 2017: Drug Development Research
https://www.readbyqxmd.com/read/28917316/humoral-and-cytokine-response-elicited-during-immunisation-with-recombinant-immune-mapped-protein-1-etimp-1-and-oocysts-of-eimeria-tenella
#5
Krishnendu Kundu, Rajat Garg, Saroj Kumar, Mrityunjay Mandal, Fiona M Tomley, Damer P Blake, Partha Sarathi Banerjee
Eimeria tenella, the causative agent of caecal coccidiosis, is a pathogenic gut dwelling protozoan which can cause severe morbidity and mortality in farmed chickens. Immune mapped protein-1 (IMP-1) has been identified as an anticoccidial vaccine candidate; in the present study allelic polymorphism was assessed across the IMP-1 coding sequence in E. tenella isolates from four countries and compared with the UK reference Houghton strain. Nucleotide diversity was low, limited to expansion/contraction of a CAG triplet repeat and five substitutions, three of which were non-synonymous...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28913731/inter-and-intra-observer-reproducibility-of-quantitative-analysis-for-fp-cit-spect-in-patients-with-dlb
#6
Atsutaka Okizaki, Michihiro Nakayama, Kaori Nakajima, Takayuki Katayama, Takahiro Uno, Fumiyoshi Morikawa, Juichiro Naoe, Koji Takahashi
BACKGROUND: Dopamine transporter single photon emission CT (DAT-SPECT) is useful in the evaluation of dementia with Lewy bodies (DLB). The specific binding ratio (SBR) is an index to measure DAT density. However, poorly reproducible cases are occasionally experienced in clinical practice. We hypothesized that distance-weighted histogram (DWH) may be useful to improve the reproducibility of SBR. The purpose of this study was to investigate inter- and intra-observer reproducibility of SBR with conventional and DWH methods, and to visually evaluate the precision in reference voxel of interest (VOI) definition using these methods...
September 14, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28912088/sip-and-spit-or-sip-and-swallow-choice-of-method-differentially-alters-taste-intensity-estimates-across-stimuli
#7
Cordelia A Running, John E Hayes
While the myth of the tongue map has been consistently and repeatedly debunked in controlled studies, evidence for regional differences in suprathreshold intensity has been noted by multiple research groups. Given differences in physiology between the anterior and posterior tongue (fungiform versus foliate and circumvallate papillae) and differences in total area stimulated (anterior only versus whole tongue, pharynx, and epiglottis), small methodological changes (sip and spit versus sip and swallow) have the potential to substantially influence data...
September 11, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28898730/immunogenicity-of-orfv-based-vectors-expressing-the-rabies-virus-glycoprotein-in-livestock-species
#8
Mathias Martins, Lok R Joshi, Fernando S Rodrigues, Deniz Anziliero, Rafael Frandoloso, Gerald F Kutish, Daniel L Rock, Rudi Weiblen, Eduardo F Flores, Diego G Diel
The parapoxvirus Orf virus (ORFV) encodes several immunomodulatory proteins (IMPs) that modulate host-innate and pro-inflammatory responses and has been proposed as a vaccine delivery vector for use in animal species. Here we describe the construction and characterization of two recombinant ORFV vectors expressing the rabies virus (RABV) glycoprotein (G). The RABV-G gene was inserted in the ORFV024 or ORFV121 gene loci, which encode for IMPs that are unique to parapoxviruses and inhibit activation of the NF-κB signaling pathway...
September 9, 2017: Virology
https://www.readbyqxmd.com/read/28893276/imipramine-blocks-acute-silicosis-in-a-mouse-model
#9
Rupa Biswas, Kevin L Trout, Forrest Jessop, Jack R Harkema, Andrij Holian
BACKGROUND: Inhalation of crystalline silica is associated with pulmonary inflammation and silicosis. Although silicosis remains a prevalent health problem throughout the world, effective treatment choices are limited. Imipramine (IMP) is a FDA approved tricyclic antidepressant drug with lysosomotropic characteristics. The aim of this study was to evaluate the potential for IMP to reduce silicosis and block phagolysosome membrane permeabilization. METHODS: C57BL/6 alveolar macrophages (AM) exposed to crystalline silica ± IMP in vitro were assessed for IL-1β release, cytotoxicity, particle uptake, lysosomal stability, and acid sphingomyelinase activity...
September 11, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28889104/machine-learning-analysis-identifies-drosophilagrunge-atrophin-as-an-important-learning-and-memory-gene-required-for-memory-retention-and-social-learning
#10
Balint Z Kacsoh, Casey S Greene, Giovanni Bosco
High throughput experiments are becoming increasingly common, and scientists must balance hypothesis driven experiments with genome wide data acquisition. We sought to predict novel genes involved in Drosophila learning and long-term memory from existing public high-throughput data. We performed an analysis using PILGRM, which analyzes public gene expression compendia using machine learning. We evaluated the top prediction alongside genes involved in learning and memory in IMP, an interface for functional relationship networks...
September 9, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28887466/hplc-based-quantification-of-bacterial-housekeeping-nucleotides-and-alarmone-messengers-ppgpp-and-pppgpp
#11
Vallo Varik, Sofia Raquel Alves Oliveira, Vasili Hauryliuk, Tanel Tenson
Here we describe an HPLC-based method to quantify bacterial housekeeping nucleotides and the signaling messengers ppGpp and pppGpp. We have replicated and tested several previously reported HPLC-based approaches and assembled a method that can process 50 samples in three days, thus making kinetically resolved experiments feasible. The method combines cell harvesting by rapid filtration, followed by acid extraction, freeze-drying with chromatographic separation. We use a combination of C18 IPRP-HPLC (GMP unresolved and co-migrating with IMP; GDP and GTP; AMP, ADP and ATP; CTP; UTP) and SAX-HPLC in isocratic mode (ppGpp and pppGpp) with UV detection...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877349/development-of-the-quality-of-reaching-in-infants-with-cerebral-palsy-a-kinematic-study
#12
Anke G Boxum, Sacha La Bastide-Van Gemert, Linze-Jaap Dijkstra, Elisa G Hamer, Tjitske Hielkema, Heleen A Reinders-Messelink, Mijna Hadders-Algra
AIM: To assess development of reaching and head stability in infants at very high risk (VHR-infants) of cerebral palsy (CP) who did and did not develop CP. METHOD: This explorative longitudinal study assessed the kinematics of reaching and head sway in sitting in 37 VHR-infants (18 CP) one to four times between 4.7 months and 22.6 months corrected age. Developmental trajectories were calculated using linear mixed effect models. Motor function was evaluated with the Infant Motor Profile (IMP) around 13 months corrected age...
September 6, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28872527/muscle-microvascular-blood-flow-oxygenation-ph-and-perfusion-pressure-decrease-in-simulated-acute-compartment-syndrome
#13
Sravya T Challa, Alan R Hargens, Amarachi Uzosike, Brandon R Macias
BACKGROUND: The current gold standard for diagnosing acute compartment syndrome (ACS) is an assessment of clinical signs, invasive measurement of intramuscular pressure (IMP), and measurement of local perfusion pressure. However, IMP measurements have several shortcomings, including pain, risk of infection, risk of technique error, plugging of the catheter tip, lack of consensus on the diagnostic pressure threshold, and lack of specificity and sensitivity. The objective of this study was to evaluate muscle hemodynamics, oxygenation, and pH as diagnostic parameters in a human model of ACS...
September 6, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28871245/comparative-genomic-analysis-of-neutrophilic-iron-ii-oxidizer-genomes-for-candidate-genes-in-extracellular-electron-transfer
#14
Shaomei He, Roman A Barco, David Emerson, Eric E Roden
Extracellular electron transfer (EET) is recognized as a key biochemical process in circumneutral pH Fe(II)-oxidizing bacteria (FeOB). In this study, we searched for candidate EET genes in 73 neutrophilic FeOB genomes, among which 43 genomes are complete or close-to-complete and the rest have estimated genome completeness ranging from 5 to 91%. These neutrophilic FeOB span members of the microaerophilic, anaerobic phototrophic, and anaerobic nitrate-reducing FeOB groups. We found that many microaerophilic and several anaerobic FeOB possess homologs of Cyc2, an outer membrane cytochrome c originally identified in Acidithiobacillus ferrooxidans...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28870092/emergence-of-arma-and-rmtb-genes-among-vim-ndm-and-imp-metallo-%C3%AE-lactamase-producing-multidrug-resistant-gram-negative-pathogens
#15
Sangeetha Gopalakrishnan, Arunagiri Kamalanathan, Sivaranjani Rajan, Vijay Manohar Bhagat, M K Showkath Ali
In the recent years, it has been noted that microorganisms with acquired resistance to almost all available potent antibiotics are increasing worldwide. Hence, the use of antibiotics in every clinical setup has to be organized to avoid irrational use of antibiotics. This study was aimed to establish the pattern of antibiotic sensitivity and relevance of antimicrobial resistance in aerobic Gram-negative bacilli. A total of 103 aerobic Gram-negative bacteria namely Escherichia coli, Klebsiella pneumoniae, Enterobacter spp...
September 5, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28866638/prediction-of-hyperperfusion-phenomenon-after-carotid-artery-stenting-and-carotid-angioplasty-using-quantitative-dsa-with-cerebral-circulation-time-imaging
#16
Keita Yamauchi, Yukiko Enomoto, Katharina Otani, Yusuke Egashira, Toru Iwama
BACKGROUND: Hyperperfusion syndrome after carotid interventions has a low incidence but it can lead to morbidity and mortality. OBJECTIVE: To evaluate the usefulness of quantitative DSA for predicting hyperperfusion phenomenon (HPP) after carotid artery stenting and angioplasty. METHODS: Thirty-three consecutive patients with carotid stenosis treated with carotid artery stenting or angioplasty between February 2014 and August 2016 were included...
September 2, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28859384/symptom-association-latency-during-ambulatory-reflux-monitoring-a-review-of-1445-symptoms
#17
M Abdul-Hussein, D Castell
To determine the optimal time window of symptom association in GERD patient, a 2-minute time window is nonapplicable for all gastroesophageal reflux (GERD) symptoms and 5 minutes remains an arbitrary choice. Symptom association analysis is a critical component in pH-impedance (imp) testing. Symptom index (SI) and symptom association probability (SAP) are the two widely accepted methods. Both were introduced in the preimpedance era and initially tested in patients with typical GERD symptoms. We reviewed ambulatory pH-imp studies of (294) patients referred for evaluation of possible GERD symptoms from January 2012 to August 2015...
October 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28858728/a-carbapenem-antibiotic-imipenem-cilastatin-induces-an-oxidative-stress-status-and-gonadotoxic-effects-in-%C3%A2-wistar-%C3%A2-rats
#18
Amal Tahri, Kamilia Ksouda, Rim Kallel, Salima Daoud, Tahia Boudawara, Khaled Mounir Zeghal, Zouheir Sahnoun
Imipenem is a carbapenem antibiotic largely used to treat infection diseases. The present study was designed to investigate the effects of imipenem/cilastatin (IMP) on oxidative stress, antioxidant levels, testicular structure and sperm parameters in rats. Adult Wistar rats (84days old; N=8/group) were treated intraperitoneally with physiological serum containing 0mg/kg, 30mg/kg, 50mg/kg and 80mg/kg of IMP for one week. The results revealed that exposure to IMP especially at high doses, significantly decreased sexual organs weights (testis, epididymis, seminal vesicle and prostate), sperm characteristics (motility, viability and count) and plasma testosterone level while increased sperm abnormality...
August 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28858124/an-injury-mortality-prediction-based-on-the-anatomic-injury-scale
#19
Muding Wang, Dan Wu, Wusi Qiu, Weimi Wang, Yunji Zeng, Yi Shen
To determine whether the injury mortality prediction (IMP) statistically outperforms the trauma mortality prediction model (TMPM) as a predictor of mortality.The TMPM is currently the best trauma score method, which is based on the anatomic injury. Its ability of mortality prediction is superior to the injury severity score (ISS) and to the new injury severity score (NISS). However, despite its statistical significance, the predictive power of TMPM needs to be further improved.Retrospective cohort study is based on the data of 1,148,359 injured patients in the National Trauma Data Bank hospitalized from 2010 to 2011...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28856222/comparison-of-clinical-methods-for-detecting-carbapenem-resistant-enterobacteriaceae
#20
Kirsten Kost, Jumi Yi, Beverly Rogers, Robert Jerris
We evaluated detection of carbapenem-resistant Enterobacteriaceae (CRE) by routine minimal inhibitory concentration (MIC) testing, polymerase chain reaction (PCR) using Xpert® Carba-R assay, hydrolysis of ertapenem and imipenem detected by matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS), and hydrolysis by colorimetry using the EPI-CRE assay. Ninety-six Enterobacteriaceae isolates possessing carbapenemase genes and 29 carbapenem-susceptible Enterobacteriaceae were available for testing...
August 2017: Pract Lab Med
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