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https://www.readbyqxmd.com/read/29346621/assessing-polymyalgia-rheumatica-activity-when-c-reactive-protein-is-unavailable-or-uninterpretable
#1
Valérie Devauchelle-Pensec, Lea Saraux, Jean Marie Berthelot, Michel De Bandt, Divi Cornec, Dewi Guellec, Thierry Marhadour, Sandrine Jousse-Joulin, Maelenn Gouillou, Alain Saraux
Objective: The PMR activity score (PMR-AS) includes the CRP value, which may be lacking or invalid owing to anti-IL-6 therapy. Our objective was to develop alternatives to PMR-AS that do not require CRP. Methods: We used the Club Rhumatisme et Inflammation (CRI; 89 patients with PMR) and the Tolerance and Efficacy of tocilizumab iN pOlymyalgia Rheumatica (TENOR; 20 patients with recent-onset PMR naive to glucocorticoid who received three tocilizumab infusions, at weeks 0, 4 and 8, followed by prednisone from weeks 12 to 24) cohorts...
January 15, 2018: Rheumatology
https://www.readbyqxmd.com/read/29340452/detection-of-multidrug-resistant-pseudomonas-aeruginosa-harboring-bla-ges-1-and-bla-ges-11-in-recife-brazil
#2
Valdemir Vicente da Silva Júnior, Laura Durão Ferreira, Lílian Rodrigues Alves, Adriane Borges Cabral, Paula Regina Luna de Araújo Jácome, Paulo Sérgio Ramos de Araújo, Ana Catarina de Souza Lopes, Maria Amélia Vieira Maciel
INTRODUCTION: Pseudomonas aeruginosa, an important pathogen globally, presents several resistance mechanisms. This study aimed to investigate the presence of bla GES in clinical isolates of Pseudomonas aeruginosa obtained from various clinical specimens from patients admitted to three different hospitals in Recife, Brazil. The Guiana extended spectrum beta-lactamase (GES) enzymes are responsible for conferring broad spectrum resistance to beta-lactam drugs, including the carbapenems. METHODS: A total of 100 carbapenem-resistant P...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29337164/identification-of-novel-antivirals-inhibiting-recognition-of-venezuelan-equine-encephalitis-virus-capsid-protein-by-the-importin-%C3%AE-%C3%AE-1-heterodimer-through-high-throughput-screening
#3
David R Thomas, Lindsay Lundberg, Chelsea Pinkham, Sharon Shechter, Aaron Debono, Jonathan Baell, Kylie M Wagstaff, Caroline A Hick, Kylene Kehn-Hall, David A Jans
Although the alphavirus Venezuelan equine encephalitis virus (VEEV) has been the cause of multiple outbreaks resulting in extensive human and equine mortality and morbidity, there are currently no anti-VEEV therapeutics available. VEEV pathogenicity is largely dependent on targeting of the viral capsid protein (CP) to the host cell nucleus through the nuclear transporting importin (Imp) α/β1 heterodimer. Here we perform a high-throughput screen, combined with nested counterscreens to identify small molecules able to inhibit the Impα/β1:CP interaction for the first time...
January 11, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29333467/a-simple-non-invasive-i-123-imp-autoradiography-method-developed-by-modifying-the-simple-non-invasive-i-123-imp-microsphere-method
#4
Asato Ofuji, Rieko Nagaoka, Kosuke Yamashita, Akihiro Takaki, Shigeki Ito
Objectives: We developed a simple non-invasive I-123-N-isopropyl-p-iodoamphetamine (123I-IMP) quantification method by analyzing chest RI-angiography and single photon emission computed tomography (SPECT) images based on the microsphere model (SIMS method). Theoretically, the SIMS method could be changed to the simple non-invasive ARG (SIARG) method by modifying the integrated washout ratio (WR) to one-point WR. If the regional cerebral blood flow (rCBF) values derived from the SIARG and ARG methods correlate well, the facilities employing the ARG method can easily switch to the SIARG method...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29329872/development-and-validation-of-a-hilic-uv-method-for-the-determination-of-nucleotides-in-fish-samples
#5
Maria Logotheti, Konstantina Theochari, Marios Kostakis, Ioannis N Pasias, Nikolaos S Thomaidis
The aim of this work was the development of a simple, novel and accurate method for the determination of adenosine triphosphate (ATP) and its first five catabolites: adenosine diphosphate (ADP), adenosine monophosphate (AMP), inosine monophosphate (IMP), inosine (Ino) and hypoxanthine (Hx), in fish tissue, based on hydrophilic interaction liquid chromatography (HILIC). For this purpose, a stationary phase for polar and hydrophilic compounds (ZIC-pHILIC) was used. The effect of different chromatographic parameters and the molecular mechanism based on the van't Hoff plot were examined...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329318/erythrocyte-inosine-triphosphatase-activity-a-potential-biomarker-for-adverse-events-during-combination-antiretroviral-therapy-for-hiv
#6
N Chantal Peltenburg, Jörgen Bierau, Jaap A Bakker, Jolanda A Schippers, Selwyn H Lowe, Aimée D C Paulussen, Bianca J C van den Bosch, Mathie P G Leers, Bettina E Hansen, Annelies Verbon
The purine analogues tenofovir and abacavir are precursors of potential substrates for the enzyme Inosine 5'-triphosphate pyrophosphohydrolase (ITPase). Here, we investigated the association of ITPase activity and ITPA genotype with the occurrence of adverse events (AEs) during combination antiretroviral therapy (cART) for human immunodeficiency virus (HIV) infection. In 393 adult HIV-seropositive patients, AEs were defined as events that led to stop of cART regimen. ITPase activity ≥4 mmol IMP/mmol Hb/hour was considered as normal...
2018: PloS One
https://www.readbyqxmd.com/read/29327002/charge-separation-properties-of-ta3n5-photoanodes-synthesized-via-a-simple-metal-organic-precursor-decomposition-process
#7
Sung Gyu Han, Sang Youn Chae, Si Young Lee, Byoung Koun Min, Yun Jeong Hwang
Here, we successfully synthesized a Ta3N5 thin film using a simple metal-organic-precursor decomposition process followed by its conversion to nitride and studied its photoelectrochemical (PEC) properties to understand charge separation on the surface. Newly synthesized Ta3N5 photoanodes showed a significant difference in the PEC activity in relation to the annealing temperature under ammonia flow, although similar light absorption properties or electronic states were obtained. Charge separation related PEC properties were analyzed using intensity modulated photocurrent density spectroscopy (IMPS) and photocurrent measurements in the absence/presence of scavengers...
January 12, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29322325/histochemical-evidence-of-igf2-mrna-binding-protein-2-mediated-regulation-of-osteoclast-function-and-adhesive-ability
#8
Hongrui Liu, Dongfang Li, Shanshan Liu, Zhaopeng Liu, Minqi Li
Insulin-like growth factor 2 (IGF2) messenger RNA-binding proteins (IMPs) are a family of oncofetal RNA-binding proteins that play important roles in cell migration, renewal, and metabolism. IMP2 gene expression may be important in determining IGF2 levels and might, thereby, be central to bone metabolism. In our present study, IMP2-deficient mice exhibited more immature bone structures, characterized by abundant residual cartilage cores; growth plates containing more rich cartilage matrix, which was arranged irregularly; and a significantly thicker hypertrophic chondrocyte layer in the femoral metaphysis, compared with wild-type mice...
January 10, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29322164/efficacy-of-transdermal-estradiol-and-micronized-progesterone-in-the-prevention-of-depressive-symptoms-in-the-menopause-transition-a-randomized-clinical-trial
#9
Jennifer L Gordon, David R Rubinow, Tory A Eisenlohr-Moul, Kai Xia, Peter J Schmidt, Susan S Girdler
Importance: The menopause transition and early postmenopausal period are associated with a 2- to 4-fold increased risk for clinically significant depressive symptoms. Although a few studies suggest that hormone therapy can effectively manage existing depression during this time, to our knowledge, there have been no studies testing whether hormone therapy can prevent the onset of perimenopausal and early postmenopausal depressive symptoms. Objective: To examine the efficacy of transdermal estradiol plus intermittent micronized progesterone (TE+IMP) in preventing depressive symptom onset among initially euthymic perimenopausal and early postmenopausal women...
January 10, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29319510/metallo-beta-lactamase-producing-pseudomonas-aeruginosa-in-a-healthcare-setting-in-alexandria-egypt
#10
Amani F Abaza, Soraya A El Shazly, Heba S A Selim, Gehan S A Aly
Pseudomonas aeruginosa has emerged as a major healthcare associated pathogen that creates a serious public health disaster in both developing and developed countries. In this work we aimed at studying the occurrence of metallo-beta-lactamase (MBL) producing P. aeruginosa in a healthcare setting in Alexandria, Egypt. This cross sectional study included 1583 clinical samples that were collected from patients admitted to Alexandria University Students' Hospital. P. aeruginosa isolates were identified using standard microbiological methods and were tested for their antimicrobial susceptibility patterns using single disc diffusion method according to the Clinical and Laboratory Standards Institute recommendations...
September 27, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29311089/molecular-characterization-of-imp-1-producing-enterobacter-cloacae-complex-isolates-in-tokyo
#11
Kotaro Aoki, Sohei Harada, Koji Yahara, Yoshikazu Ishii, Daisuke Motooka, Shota Nakamura, Yukihiro Akeda, Tetsuya Iida, Kazunori Tomono, Satoshi Iwata, Kyoji Moriya, Kazuhiro Tateda
Although KPC enzymes are most common among carbapenemases produced by Enterobacter cloacae complex globally, the epidemiology varies from one country to another. While previous studies have suggested that IMP enzymes are most common in Japan, detailed analysis has been scarce thus far. Here we carried out a molecular epidemiological study and plasmid analysis of IMP-1-producing E. cloacae complex isolates collected from 3 hospitals in central Tokyo using whole genome sequencing. Seventy-one isolates were classified into several STs and 49 isolates were identified as Enterobacter hormaechei ST78...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29306799/purine-salvage-in-plants
#12
REVIEW
Hiroshi Ashihara, Claudio Stasolla, Tatsuhito Fujimura, Alan Crozier
Purine bases and nucleosides are produced by turnover of nucleotides and nucleic acids as well as from some cellular metabolic pathways. Adenosine released from the S-adenosyl-L-methionine cycle is linked to many methyltransferase reactions, such as the biosynthesis of caffeine and glycine betaine. Adenine is produced by the methionine cycles, which is related to other biosynthesis pathways, such those for the production of ethylene, nicotianamine and polyamines. These purine compounds are recycled for nucleotide biosynthesis by so-called "salvage pathways"...
January 4, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29305547/evaluation-of-the-amplidiag-carbar-vre-kit-for-the-accurate-detection-of-carbapenemase-producing-bacteria
#13
Saoussen Oueslati, Delphine Girlich, Laurent Dortet, Thierry Naas
As carbapenemase-producing Gram-negative bacilli (CP-GNB) (Enterobacteriaceae, Pseudomonadaceae and Acinetobacter spp.) are becoming a major public health issue, there is an urgent need for accurate and fast diagnostic tests. Amplidiag® Carba-R+VRE assay is a multiplex nucleic acid-based in-vitro diagnostic test intended for the detection of CP-GNB and vancomycin resistant enterococci (VRE) from cultured colonies.We have evaluated its ability to detect carbapenemases genes in 100 well-characterized GNB, and in 200 consecutive enterobacterial isolates with reduced susceptibility to carbapenems and that were referred to the French National Reference Center for carbapenem-resistance...
January 5, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29296273/new-delhi-metallo-%C3%AE-lactamase-1-producing-klebsiella-pneumoniae-isolates-in-hospitalized-patients-in-kashan-iran
#14
Farzaneh Firoozeh, Zeinab Mahluji, Ehsaneh Shams, Ahmad Khorshidi, Mohammad Zibaei
Background and Objectives: New Delhi metallo-ß-lactamase (NDM) is a newly emerging metallo-ß-lactamases, which can destroy all β-lactams including carbapenems. Therefore, this study aimed at evaluating New Delhi metallo-ß-lactamase-1-production in clinical isolates of Klebsiella pneumoniae in Kashan, Iran. Materials and Methods: In a cross-sectional study, 181 K. pneumoniae isolates were collected from clinical samples of patients, who referred to Shahid Beheshi hospital in Kashan during November 2013 and October 2014...
October 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29291172/the-american-college-of-academic-international-medicine-2017-consensus-statement-on-international-medical-programs-establishing-a-system-of-objective-valuation-and-quantitative-metrics-to-facilitate-the-recognition-and-incorporation-of-academic-international
#15
Gregory L Peck, Manish Garg, Bonnie Arquilla, Vicente H Gracias, Harry L Anderson Iii, Andrew C Miller, Bhakti Hansoti, Paula Ferrada, Michael S Firstenberg, Sagar C Galwankar, Ramon E Gist, Donald Jeanmonod, Rebecca Jeanmonod, Elizabeth Krebs, Marian P McDonald, Benedict Nwomeh, James P Orlando, Lorenzo Paladino, Thomas J Papadimos, Robert L Ricca, Joseph V Sakran, Richard P Sharpe, Mamta Swaroop, Stanislaw P Stawicki
The growth of academic international medicine (AIM) as a distinct field of expertise resulted in increasing participation by individual and institutional actors from both high-income and low-and-middle-income countries. This trend resulted in the gradual evolution of international medical programs (IMPs). With the growing number of students, residents, and educators who gravitate toward nontraditional forms of academic contribution, the need arose for a system of formalized metrics and quantitative assessment of AIM- and IMP-related efforts...
October 2017: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/29291171/a-comprehensive-framework-for-international-medical-programs-a-2017-consensus-statement-from-the-american-college-of-academic-international-medicine
#16
Manish Garg, Gregory L Peck, Bonnie Arquilla, Andrew C Miller, Sari E Soghoian, Harry L Anderson Iii, Christina Bloem, Michael S Firstenberg, Sagar C Galwankar, Weidun Alan Guo, Ricardo Izurieta, Elizabeth Krebs, Bhakti Hansoti, Sudip Nanda, Chinenye O Nwachuku, Benedict Nwomeh, Lorenzo Paladino, Thomas J Papadimos, Richard P Sharpe, Mamta Swaroop, Stanislaw P Stawicki
The American College of Academic International Medicine (ACAIM) represents a group of clinicians who seek to promote clinical, educational, and scientific collaboration in the area of Academic International Medicine (AIM) to address health care disparities and improve patient care and outcomes globally. Significant health care delivery and quality gaps persist between high-income countries (HICs) and low-and-middle-income countries (LMICs). International Medical Programs (IMPs) are an important mechanism for addressing these inequalities...
October 2017: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/29287811/biomechanical-simulation-of-stresses-and-strains-exerted-on-the-spinal-cord-and-nerves-during-scoliosis-correction-maneuvers
#17
Juan Henao, Hubert Labelle, Pierre-Jean Arnoux, Carl-Éric Aubin
STUDY DESIGN: Biomechanical analysis of the spinal cord and nerves during scoliosis correction maneuvers through numerical simulations. OBJECTIVE: To assess the biomechanical effects of scoliosis correction maneuvers and stresses generated on the spinal nervous structures. BACKGROUND DATA: Important forces are applied during scoliosis correction surgery, which could potentially lead to neurologic complications due to stresses exerted on the nervous structures...
January 2018: Spine Deformity
https://www.readbyqxmd.com/read/29285477/pseudomonas-aeruginosa-producing-metallo-%C3%AE-lactamases-vim-imp-sme-and-aim-in-the-clinical-isolates-of-intensive-care-units-a-university-hospital-in-isfahan-iran
#18
Farzin Khorvash, Mohammadreza Yazdani, Shiva Shabani, Aliasghar Soudi
Background: Pseudomonas aeruginosa is a severe challenge for antimicrobial therapy, due to the chromosomal mutations or exhibition of intrinsic resistance to various antimicrobial agents such as most β-lactams. We undertook this study to evaluate the existence of SME, IMP, AIM, and VIM metallo-β-lactamases (MBL) encoding genes among P. aeruginosa strains isolated from Intensive Care Unit (ICU) patients in Al-Zahra Hospital in Isfahan, Iran. Materials and Methods: In a retrospective cross-sectional study that was conducted between March 2012 and April 2013, a total of 48 strains of P...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29279453/evaluation-of-the-filmarray-blood-culture-identification-panel-in-detecting-pathogenic-microorganisms-from-positive-blood-cultures-the-first-clinical-report-in-japan
#19
Kyoichi Saito, Shiro Endo, Makoto Katsumi, Chiyuki Ishizawa, Yuko Fujikawa, Shinya Inomata, Masahiro Toyokawa, Mitsuo Kaku
  The FilmArray (FA) is a multiplex polymerase chain reaction (PCR)-based desktop microbial detection system. The Blood Culture Identification (BCID) panel is an adaptable panel for the FA, which diagnoses sepsis or/and systemic infections by detecting 14 bacterial species, 4 bacterial genera, 1 bacterial family, 5 yeast species, and 3 antimicrobial resistance genes (mecA, KPC, and vanA/B) from positive blood cultures within 1 hour. We retrospectively evaluated the FA-BCID panel, using 54 positive blood cultures, from which 57 bacteria and 3 yeasts were identified through matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) analysis...
December 26, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29274802/susceptibility-testing-and-detection-of-%C3%AE-lactam-resistance-mechanisms-in-enterobacteriaceae-a-multicentre-national-proficiency-study
#20
María Díez-Aguilar, María-Carmen Conejo, María-Isabel Morosini, Núria Tormo Palop, Concepción Gimeno, Rafael Cantón, Álvaro Pascual
A nationwide study was developed to evaluate the ability of 60 Spanish clinical microbiology laboratories to predict the underlying β-lactam resistance mechanisms of 12 Enterobacteriaceae strains (CCS01-CCS12). Results obtained by two reference laboratories were compared with those reported by the participants that used their own routine susceptibility testing methodology. CLSI interpretive criteria were used in 53.3% of the centres, while 46.7% used EUCAST. The overall categorical agreement (CA) was 85.5%...
December 21, 2017: International Journal of Antimicrobial Agents
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