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https://www.readbyqxmd.com/read/27903552/application-of-an-untargeted-chemometric-strategy-in-the-impurity-profiling-of-pharmaceuticals-an-example-of-amisulpride
#1
Robert Skibiński, Jakub Trawiński
The untargeted chemometric methodology for the impurity profiling of amisulpride pharmaceutical formulations was successfully applied and developed. For this purpose a fast, accurate and specific analytical method was elaborated with the use of ultra high pressure liquid chromatography coupled with high resolution hybrid electrospray ionization quadrupole time of flight mass spectrometer in a fast polarity switching mode. All the obtained chromatographic profiles were aligned and a multivariate chemometric analysis including principal component analysis and partial least square (PLS) was performed...
November 29, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27898853/cookery-method-and-endpoint-temperature-can-affect-the-warner-bratzler-shear-force-cooking-loss-and-internal-cooked-color-of-beef-semimembranosus-and-infraspinatus-steaks
#2
J W S Yancey, J K Apple, M D Wharton
Steaks from USDA Select inside rounds (Exp. 1) and shoulder clods (Exp. 2) were used to test the interactive effect of cookery method and endpoint temperature on Warner-Bratzler shear force (WBSF) and internal cooked color. Pairs of 2.5-cm-thick semimembranosus (SM) or infraspinatus (INF) steaks ( = 360/muscle) were cut from each subprimal, labeled, vacuum packaged, and frozen at -30°C in the dark for approximately 60 d before being cooked to 65.5, 71.1, or 76.6°C using 1) a forced-air convection oven (FAC); 2) a forced-air impingement oven (IMP); 3) a gas-fired, open-hearth charbroiler (CHAR); 4) an electric countertop griddle (GRID); or 5) a clam-shell grill (CLAM)...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27897064/diagnosis-of-dementia-with-lewy-bodies-can-123-i-imp-and-123-i-mibg-scintigraphy-yield-new-core-features
#3
Fumi Sakamoto, Shinya Shiraishi, Noriko Tsuda, Mamoru Hashimoto, Seiji Tomiguchi, Manabu Ikeda, Yasuyuki Yamashita
OBJECTIVE: Since the clinical symptoms of different types of dementia frequently overlap, especially in the earlier stages at onset, it is difficult to distinguish dementias with Lewy bodies (DLB) from other neurodegenerative dementias based on their clinical manifestations alone. Nuclear medicine imaging has been reported as a high-value index for the objective evaluation and diagnosis of DLB. The aim of this study was to evaluate whether nuclear medicine imaging findings may yield core features to be added to the diagnosis of DLB...
November 29, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27889944/intramembrane-proteases-as-drug-targets
#4
REVIEW
Steven H L Verhelst
Proteases are considered attractive drug targets. Various drugs targeting classical, soluble proteases have been approved for treatment of human disease. Intramembrane proteases (IMPs) are a more recently discovered group of proteolytic enzymes. They are embedded in lipid bilayers and their active sites are located in the plane of a membrane. All four mechanistic families of IMPs have been linked to disease, but currently, no drugs against IMPs have entered the market. In this review, I will outline the function of IMPs with a focus on the ones involved in human disease, which includes Alzheimer's disease, cancer, and infectious diseases by microorganisms...
November 27, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27882088/study-on-the-resistance-mechanism-via-outer-membrane-protein-oprd2-and-metal-%C3%AE-lactamase-expression-in-the-cell-wall-of-pseudomonas-aeruginosa
#5
Shuangqi Cai, Yiqiang Chen, Dezhi Song, Jinliang Kong, Yanbin Wu, Huasong Lu
The aim of the present study was to evaluate the imipenem-resistant mechanism via the outer membrane protein (OMP) OprD2 and metal β-lactamase expression in the cell wall of Pseudomonas aeruginosa. The Pseudomonas aeruginosa was clinically separated and validated by VITEK-2 full-automatic bacteria analyzer. Drug resistance, sensitive antibiotics and minimum inhibitory concentration (MIC) were tested using the drug sensitivity analysis system. The phenotype positive strains of MBL genes were screened using the Kirby-Bauer diffusion method by adding metal ion-chelating agent EDTA on the imipenem susceptibility paper...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27869722/virtual-distances-methodology-as-verification-technique-for-aacmms-with-a-capacitive-sensor-based-indexed-metrology-platform
#6
Raquel Acero, Jorge Santolaria, Agustin Brau, Marcos Pueo
This paper presents a new verification procedure for articulated arm coordinate measuring machines (AACMMs) together with a capacitive sensor-based indexed metrology platform (IMP) based on the generation of virtual reference distances. The novelty of this procedure lays on the possibility of creating virtual points, virtual gauges and virtual distances through the indexed metrology platform's mathematical model taking as a reference the measurements of a ball bar gauge located in a fixed position of the instrument's working volume...
November 18, 2016: Sensors
https://www.readbyqxmd.com/read/27852030/-a-case-of-pol-iii-related-leukodystrophy-with-homozygous-mutation-in-polr3a
#7
Tomoaki Shima, Takeshi Fujimoto, Teiichiro Miyazaki, Fumiaki Nonaka
We describe a 27-year-old man with mental retardation, symptomatic epilepsy, myopia, and cerebellar ataxia without spontaneous puberty whose brain magnetic resonance imaging showed hypomyelination. He had child-like facial appearance, with thin facial hair. He had no underarm and pubic hairs, and his penis was small. Laboratory tests showed low levels of luteinizing hormone, follicle-stimulating hormone, and testosterone. Brain MRI showed diffuse hypomyelination, atrophy of the cerebellum and brainstem, and hypoplastic corpus callosum...
November 2016: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/27848257/the-decision-to-have-an-abortion-from-both-partners-perspectives-a-dyadic-analysis
#8
Joke Vandamme, Ann Buysse, Tom Loeys, Carine Vrancken, Guy T'Sjoen
OBJECTIVES: Male partners are often involved in induced abortion although they have no legal rights. It is, however, unknown how women's thoughts and feelings regarding the decision for abortion are associated with the decisional experiences of the involved male partners and vice versa. METHODS: Flemish women and their involved male partners (IMP) filled out a questionnaire on abortion motives and feelings of decisiveness in the abortion centre waiting room (N = 106 couples)...
November 16, 2016: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/27827007/genomic-and-transcriptomic-resources-for-marker-development-in-synchytrium-endobioticum-an-elusive-but-severe-potato-pathogen
#9
Friederike Busse, Annette Bartkiewicz, Diro Terefe-Ayana, Frank Niepold, Yvonne Schleusner, Kerstin Flath, Nicole Sommerfeldt-Impe, Jens Lübeck, Josef Strahwald, Eckhard Tacke, Hans-Reinhard Hofferbert, Marcus Linde, Jarosław Przetakiewicz, Thomas Debener
Synchytrium endobioticum is an obligate biotrophic fungus that causes wart diseases in potato. Like other species of the Chytridiomycetes it does not form mycelia and its zoospores are small, approximately 3µm in diameter, which complicate the detection of early stages of infection. Furthermore, potato wart disease is difficult to control as belowground organs are infected and resting spores of the fungus are extremely durable. S. endobioticum is thus classified as a quarantine organism. More than 40 S. endobioticum pathotypes have been reported, of which pathotypes 1(D1), 2(G1), 6(O1), 8(F1) and 18(T1) are the most important in Germany...
November 9, 2016: Phytopathology
https://www.readbyqxmd.com/read/27818808/persistent-bacteremia-from-pseudomonas-aeruginosa-with-in-vitro-resistance-to-the-novel-antibiotics-ceftolozane-tazobactam-and-ceftazidime-avibactam
#10
Louie Mar Gangcuangco, Patricia Clark, Cynthia Stewart, Goran Miljkovic, Zane K Saul
Ceftazidime-avibactam and ceftolozane-tazobactam are new antimicrobials with activity against multidrug-resistant Pseudomonas aeruginosa. We present the first case of persistent P. aeruginosa bacteremia with in vitro resistance to these novel antimicrobials. A 68-year-old man with newly diagnosed follicular lymphoma was admitted to the medical intensive care unit for sepsis and right lower extremity cellulitis. The patient was placed empirically on vancomycin and piperacillin-tazobactam. Blood cultures from Day 1 of hospitalization grew P...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27818246/autophagy-suppression-sensitizes-glioma-cells-to-imp-dehydrogenase-inhibition-induced-apoptotic-death
#11
Andjelka M Isakovic, Marija Dulovic, Ivanka Markovic, Tamara Kravic-Stevovic, Vladimir Bumbasirevic, Vladimir Trajkovic, Aleksandra Isakovic
We investigated the role of autophagy, a process of controlled self-digestion, in the in vitro anticancer action of the inosine monophosphate dehydrogenase (IMPDH) inhibitor ribavirin. Ribavirin-triggered oxidative stress, caspase activation, and apoptotic death in U251 human glioma cells were associated with the induction of autophagy, as confirmed by intracellular acidification, appearance of autophagic vesicles, conversion of microtubule associated protein 1 light chain 3 (LC3)-I to autophagosome-associated LC3-II, and degradation of autophagic target p62/sequestosome 1...
November 3, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27816656/the-behavioral-approach-system-and-augmenting-reducing-in-auditory-event-related-potentials-during-emotional-visual-stimulation
#12
Vilfredo De Pascalis, Francesca Fracasso, Philip J Corr
In the recent Reinforcement Sensitivity Theory Personality Questionnaire (RST-PQ, Corr and Cooper, 2016) the behavioral approach system (BAS) has been conceptualized as multidimensional in which facets of reward interest and reactivity, and goal-drive persistence, are separate from impulsivity. Aim of the present work was to highlight the predictive power of BAS and its facets in differentiating electrocortical responses by using an auditory augmenting/reducing event-related potential (ERP) paradigm during emotional visual stimulation...
November 2, 2016: Biological Psychology
https://www.readbyqxmd.com/read/27809900/significance-of-nucleic-acid-testing-in-diagnosis-and-treatment-of-post-neurosurgical-meningitis-caused-by-multidrug-resistant-acinetobacter-baumannii-a-case-report
#13
Ngo Tat Trung, Trinh Van Son, Dao Thanh Quyen, Dang Thi Viet Anh, Vu Viet Sang, Nguyen Xuan Lam, Nguyen Dang Manh, Vuong Phuc Duong, Bui Tri Cuong, Quyen Dang Tuyen, Nguyen Xuan Chinh, Phan Quoc Hoan, Hoang Van Tong, Christian G Meyer, Le Huu Song
BACKGROUND: Neurosurgery may pose the risk of patients' developing nosocomial meningitis caused by infection with hospital pathogens. Rapid detection of the causative pathogens is essential for selecting the appropriate antibiotic treatment. However, the classical culture-based detection of bacterial infection is time-consuming and often fails to establish the correct diagnosis. Molecular techniques offer improved diagnostic means to guide the proper antibiotic therapy. CASE PRESENTATION: A 32-year-old Vietnamese man underwent neurosurgery and subsequently developed meningitis...
November 3, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27800466/emerging-carbapenem-resistant-pseudomonas-aeruginosa-isolates-carrying-blaimp-among-burn-patients-in-isfahan-iran
#14
Mohsen Radan, Rezvan Moniri, Ahmad Khorshidi, Hamidreza Gilasi, Zohreh Norouzi, Fahimeh Beigi, Yasaman Dasteh Goli
BACKGROUND: Metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa is a significant pathogen in burn patients. OBJECTIVES: The aim of this study was to determine the prevalence of carbapenem-resistant P. aeruginosa isolates, including those resistant to imipenemase (IMP), in a burn unit in Isfahan, Iran. PATIENTS AND METHODS: One hundred and fifty P. aeruginosa isolates from burn patients were tested for antibiotic susceptibility by the disc diffusion method in accordance with CLSI guidelines...
September 2016: Archives of Trauma Research
https://www.readbyqxmd.com/read/27795386/evaluation-of-the-carba-np-test-in-oregon-2013
#15
Karim E Morey, Robert Vega, P Maureen Cassidy, Genevieve L Buser, Jaipreet K Rayar, Jeffrey A Myers, Scott J Weissman, Zintars G Beldavs, Christopher D Pfeiffer
Carbapenem-resistant Enterobacteriaceae (CRE) are an urgent public health threat. We evaluated the capacity of the Carba NP test to detect carbapenemase production in 206 isolates: 143 Enterobacteriaceae identified by Oregon's CRE surveillance in 2013 and 63 known carbapenemase-positive organisms. Overall, test sensitivity and specificity were 89% (59/66; 95% CI 81-97%) and 100% (140/140; 95% CI 98-100%), respectively. All KPC, NDM-1, VIM, and IMP-producers but no (0/7) OXA-48-like strains were Carba NP-positive prior to a post-hoc protocol modification...
October 17, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27795336/informing-antibiotic-treatment-decisions-evaluating-rapid-molecular-diagnostics-rmds-to-identify-susceptibility-and-resistance-to-carbapenems-against-acinetobacter-spp-primers-iii
#16
Scott R Evans, Andrea M Hujer, Hongyu Jiang, Carol B Hill, Kristine M Hujer, Jose R Mediavilla, Claudia Manca, Thuy Tien T Tran, T Nicholas Domitrovic, Paul G Higgins, Harald Seifert, Barry N Kreiswirth, Robin Patel, Michael R Jacobs, Liang Chen, Rangarajan Sampath, Thomas Hall, Christine Marzan, Vance G Fowler, Henry F Chambers, Robert A Bonomo
The widespread dissemination of carbapenem-resistant Acinetobacter spp. has created significant therapeutic challenges. At present, rapid molecular diagnostics (RMDs) that can identify this phenotype are not commercially available. Two RMD platforms, polymerase chain reaction combined with electrospray ionization mass spectrometry (PCR/ESI-MS) and molecular beacons (MB), for detecting genes conferring resistance/susceptibility to carbapenems in Acinetobacter spp. were evaluated. An archived collection of 200 clinical Acinetobacter spp...
October 26, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27790429/act-fast-as-time-is-less-high-faecal-carriage-of-carbapenem-resistant-enterobacteriaceae-in-critical-care-patients
#17
Sanjith Saseedharan, Manisa Sahu, Edwin Joseph Pathrose, Sarita Shivdas
INTRODUCTION: Carbapenem-resistant Enterobacteriaceae (CRE) are drug-resistant Gram-negative bacteria that are present in the community as well as in hospitals. Their infection and colonisation puts critically ill patients at high risk due to the drug-resistant nature of the strains and possible spreading of these organisms, even in a hospital environment. AIM: To examine the presence and types of Enterobacteriaceae species in patients admitted directly from the community...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27789726/monocyte-activation-is-associated-with-worse-cognitive-performance-in-virologically-suppressed-hiv-infected-women
#18
Brandon M Imp, Leah H Rubin, Phyllis C Tien, Michael W Plankey, Elizabeth T Golub, Audrey L French, Victor G Valcour
BACKGROUND:  Cognitive impairment persists despite suppression of plasma HIV RNA. Monocyte-related immune activation is a likely mechanism. We examined immune activation and cognition in a cohort of HIV-infected and -uninfected women from the Women's Interagency HIV Study (WIHS). METHODS:  Blood levels of activation markers, soluble CD163 (sCD163), soluble CD14 (sCD14), CRP, IL-6, and a gut microbial translocation marker (intestinal fatty acid binding protein (I-FABP)) were measured in 253 women (73% HIV-infected)...
October 26, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27786284/crystal-structures-and-inhibition-of-trypanosoma-brucei-hypoxanthine-guanine-phosphoribosyltransferase
#19
David Terán, Dana Hocková, Michal Česnek, Alena Zíková, Lieve Naesens, Dianne T Keough, Luke W Guddat
Human African Trypanosomiasis (HAT) is a life-threatening infectious disease caused by the protozoan parasite, Trypanosoma brucei (Tbr). Due to the debilitating side effects of the current therapeutics and the emergence of resistance to these drugs, new medications for this disease need to be developed. One potential new drug target is 6-oxopurine phosphoribosyltransferase (PRT), an enzyme central to the purine salvage pathway and whose activity is critical for the production of the nucleotides (GMP and IMP) required for DNA/RNA synthesis within this protozoan parasite...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27784292/bacillus-subtilis-5-nucleotidases-with-various-functions-and-substrate-specificities
#20
Ayako Terakawa, Ayane Natsume, Atsushi Okada, Shogo Nishihata, Junko Kuse, Kosei Tanaka, Shinji Takenaka, Shu Ishikawa, Ken-Ichi Yoshida
BACKGROUND: In Escherichia coli, nagD, yrfG, yjjG, yieH, yigL, surE, and yfbR encode 5'-nucleotidases that hydrolyze the phosphate group of 5'-nucleotides. In Bacillus subtilis, genes encoding 5'-nucleotidase have remained to be identified. RESULTS: We found that B. subtilis ycsE, araL, yutF, ysaA, and yqeG show suggestive similarities to nagD. Here, we expressed them in E. coli to purify the respective His6-tagged proteins. YcsE exhibited significant 5'-nucleotidase activity with a broader specificity, whereas the other four enzymes had rather weak but suggestive activities with various capacities and substrate specificities...
October 26, 2016: BMC Microbiology
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