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https://www.readbyqxmd.com/read/28207879/comparison-of-hla-allelic-imputation-programs
#1
Jason H Karnes, Christian M Shaffer, Lisa Bastarache, Silvana Gaudieri, Andrew M Glazer, Heidi E Steiner, Jonathan D Mosley, Simon Mallal, Joshua C Denny, Elizabeth J Phillips, Dan M Roden
Imputation of human leukocyte antigen (HLA) alleles from SNP-level data is attractive due to importance of HLA alleles in human disease, widespread availability of genome-wide association study (GWAS) data, and expertise required for HLA sequencing. However, comprehensive evaluations of HLA imputations programs are limited. We compared HLA imputation results of HIBAG, SNP2HLA, and HLA*IMP:02 to sequenced HLA alleles in 3,265 samples from BioVU, a de-identified electronic health record database coupled to a DNA biorepository...
2017: PloS One
https://www.readbyqxmd.com/read/28202999/-changes-of-productions-of-energy-metabolism-in-masseter-of-rats-induced-by-occlusal-interference
#2
X X Xu, Y Cao, K Y Fu, Q F Xie
OBJECTIVE: To investigate the effect of occlusal interference on the energy metabolism of masticatory muscle by studying the changes of adenosine triphosphate (ATP), adenosine diphosphate (ADP), inosine monophosphate (IMP), phosphocreatine, creatine, lactate and pH level in masseter muscles of rats after occlusal interference. METHODS: Fifty male Sprague-Dawley rats were randomly assigned into experimental group (n=40) and control group (n=10). In experimental group, 0...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28194953/click-chemistry-reagent-for-identification-of-sites-of-covalent-ligand-incorporation-in-integral-membrane-proteins
#3
Melissa M Budelier, Wayland W L Cheng, Lucie Bergdoll, Zi-Wei Chen, Jeff Abramson, Kathiresan Krishnan, Mingxing Qian, Douglas F Covey, James W Janetka, Alex S Evers
Identifying sites of protein-ligand interaction is important for structure-based drug discovery and understanding protein structure-function relationships. Mass spectrometry (MS) has emerged as a useful tool for identifying residues covalently modified by ligands. Current methods use database searches that are dependent on acquiring interpretable fragmentation spectra (MS2) of peptide-ligand adducts. This is problematic for identifying sites of hydrophobic ligand incorporation in integral membrane proteins (IMPs), where poor aqueous solubility and ionization of peptide-ligand adducts and collision-induced adduct loss hinder the acquisition of quality MS2 spectra...
February 9, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28183048/potential-impurities-of-anxiolytic-drug-clobazam-identification-synthesis-and-characterization-using-hplc-lc-esi-ms-n-and-nmr
#4
Neeraj Kumar, Subba Rao Devineni, Shailendra Kumar Dubey, Pramod Kumar
During the optimization of process, eight impurities (CLB Imp-A to CLB Imp-H) were detected in few of the laboratory batches of clobazam, used as anxiolytic agent, in the range of 0.02-0.12% using gradient HPLC method with UV detection. On the basis of co-spiking analysis, six impurities (CLB Imp-A to -F) enumerated by European Pharmacopoeia, however, not reported in the earlier literature, have been harmonized and found to be two impurities are completely unknown (CLB Imp-G and -H). These two new impurities structures were presumed based on LC-ESI/MS(n) study as 8-chloro-1-methyl-5-phenyl-1,5-dihydro-3H-1,5-benzodiazepine-2,4-dione (CLB Imp-G) and 5-chloro-1-methyl-3-phenyl-1H-benzo[d]imidazol-2(3H)-one (CLB Imp-H)...
January 29, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28167555/global-molecular-epidemiology-of-imp-producing-enterobacteriaceae
#5
Yasufumi Matsumura, Gisele Peirano, Mary R Motyl, Mark D Adams, Liang Chen, Barry Kreiswirth, Rebekah DeVinney, Johann D D Pitout
International data on the molecular epidemiology of Enterobacteriaceae with IMP carbapenemases are lacking. We performed short read (Illumina) whole genomic sequencing on a global collection of 38 IMP-producing clinical Enterobacteriaceae (2008-14). IMP-producing Enterobacteriaceae (7 varieties within 11 class 1 integrons) were mainly present in South Pacific and Asia. Specific blaIMP containing integrons (In809 with blaIMP-4, In722 with blaIMP-6, In687 with blaIMP-14) were circulating among different bacteria in countries such as Australia, Japan and Thailand...
February 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28167164/experiences-of-intervertebral-motion-palpation-in-osteopathic-practice-a-qualitative-interview-study-among-swedish-osteopaths
#6
Niklas S Sposato, Kristofer Bjerså
BACKGROUND: Assessment in manual therapy includes quantitative and qualitative procedures, and intervertebral motion palpation (IMP) is one of the core assessment methods in osteopathic practice. The aim of this study was to explore osteopathic practitioners' experiences of clinical decision-making and IMP as a diagnostic tool for planning and evaluation of osteopathic interventions. METHOD: The study was conducted with semi-structured interviews that included eight informants...
January 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28161293/molecular-epidemiology-of-carbapenemase-producing-enterobacteriaceae-in-a-primary-care-hospital-in-japan-2010-2013
#7
Yuki Ohno, Akihiro Nakamura, Eriko Hashimoto, Hiroko Matsutani, Noriyuki Abe, Saori Fukuda, Kohno Hisashi, Masaru Komatsu, Fumihiko Nakamura
Recently, carbapenemase-producing Enterobacteriaceae (CPE) have been spreading worldwide and have become a threat in healthcare systems. We investigated the isolation frequency and molecular epidemiological characteristics of CPE isolated from clinical samples collected at a primary care hospital over the four years of 2010-2013 in Japan. CPE were detected in 17 (0.34%) of 4875 isolates by the broth microdilution method, sodium mercaptoacetate inhibition test, and modified Hodge test using meropenem disks. The frequency of CPE isolates was 0...
February 1, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28159278/the-role-of-microorganisms-in-the-degradation-of-adenosine-triphosphate-atp-in-chill-stored-common-carp-cyprinus-carpio-fillets
#8
Dapeng Li, Longteng Zhang, Sijia Song, Zhiying Wang, Chunli Kong, Yongkang Luo
Biochemical and microbial changes after harvest strongly affect the final quality and shelf life of fish and fish products. In this study, the role of microbes in the degradation of adenosine triphosphate (ATP), and the origin of adenosine monophosphate deaminase (AMPD) and acid phosphatase (ACP) in common carp fillets during different stages of chilled storage (at 4°C) were investigated. The content of ATP, ADP, AMP, IMP, HxR, and Hx, the activity of AMPD and ACP, and the total count of viable, Aeromonas, Pseudomonas, H2S-producing bacteria, and lactic acid bacteria were examined...
June 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28150570/identification-characterization-and-quantification-of-impurities-of-safinamide-mesilate-process-related-impurities-and-degradation-products
#9
Liang Zou, Lili Sun, Hui Zhang, Wenkai Hui, Qiaogen Zou, Zheying Zhu
The characterization of process-related impurities and degradation products of safinamide mesilate (SAFM) in bulk drugand a stability-indicating HPLC method for the separation and quantification of all the impurities were investigated. Four process-related impurities (Imp-B, Imp-C, Imp-D, and Imp-E) were found in the SAFM bulk drug. Five degradation products (Imp-A, Imp-C, Imp-D, Imp-E, and Imp-F) were observed in SAFM under oxidative conditions. Imp-C, Imp-D, and Imp-E were also degradation products and process-related impurities...
February 2, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28149574/ischemic-mitral-valve-prolapse
#10
REVIEW
Francesco Nappi, Spadaccio Cristiano, Antonio Nenna, Massimo Chello
Ischemic mitral prolapse (IMP) is a pathologic entity encountered in about one-third among the patients undergoing surgery for ischemic mitral regurgitation (IMR). IMP is generally the result of a papillary muscle injury consequent to myocardial, but the recent literature is progressively unveiling a more complex pathogenesis. The mechanisms underlying its development regards the impairment of one or more components of the mitral apparatus, which comprises the annulus, the chordae tendineae, the papillary muscle and the left ventricular wall...
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28149077/outcome-prediction-after-traumatic-brain-injury-comparison-of-the-performance-of-routinely-used-severity-scores-and-multivariable-prognostic-models
#11
Marek Majdan, Alexandra Brazinova, Martin Rusnak, Johannes Leitgeb
OBJECTIVES: Prognosis of outcome after traumatic brain injury (TBI) is important in the assessment of quality of care and can help improve treatment and outcome. The aim of this study was to compare the prognostic value of relatively simple injury severity scores between each other and against a gold standard model - the IMPACT-extended (IMP-E) multivariable prognostic model. MATERIALS AND METHODS: For this study, 866 patients with moderate/severe TBI from Austria were analyzed...
January 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28144604/evaluation-of-metallo-%C3%AE-lactamase-production-and-carriage-of-bla-vim-genes-in-pseudomonas-aeruginosa-isolated-from-burn-wound-infections-in-isfahan
#12
Mahmood Saffari, Farzaneh Firoozeh, Mohammad Pourbabaee, Mohammad Zibaei
BACKGROUND: Metallo-β-lactamase-production among Gram-negative bacteria, including Pseudomonas aeruginosa, has become a challenge for treatment of infections due to these resistant bacteria. OBJECTIVES: The aim of the current study was to evaluate the metallo-β-lactamase-production and carriage of bla-VIM genes among carbapenem-resistant P. aeruginosa isolated from burn wound infections. PATIENTS AND METHODS: A cross-sectional study was conducted from September 2014 to July 2015...
December 2016: Archives of Trauma Research
https://www.readbyqxmd.com/read/28130409/reduced-metabolism-in-the-hypothalamus-of-the-anorectic-anx-anx-mouse
#13
Ulrika Bergström, Charlotte Lindfors, Marie Svedberg, Jeanette E Johansen, Jenny Häggkvist, Martin Schalling, Rolf Wibom, Abram Katz, Ida Ak Nilsson
The anorectic anx/anx mouse exhibits a mitochondrial complex I dysfunction that is related to aberrant expression of hypothalamic neuropeptides and transmitters regulating food intake. Hypothalamic activity, i.e. neuronal firing and transmitter release, is dependent on glucose utilization and energy metabolism. To better understand the role of hypothalamic activity in anorexia, we assessed carbohydrate and high energy phosphate metabolism, in vivo and in vitro, in the anx/anx hypothalamus. In the fasted state, hypothalamic glucose uptake in the anx/anx mouse was reduced by ~50% of that seen in wild type (wt) mice (P<0...
January 27, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28126702/stevia-based-sweeteners-as-a-promising-alternative-to-table-sugar-the-effect-on-listeria-monocytogenes-and-salmonella-typhimurium-growth-dynamics
#14
María M Lobete, Maria Baka, Estefanía Noriega, Etienne Jooken, Annick Monballiu, Sam de Beurme, Boudewijn Meesschaert, Jan F Van Impe
Sugar is commonly substituted with stevia-based products in food industry and in our daily-life. This substitution results in a change in food product characteristic formula and properties that may affect the growth dynamics of food pathogenic and spoilage bacteria. This work studies the effect of table sugar (TS), laboratory sucrose (LS), commercial stevia (St) and steviol glycosides (SG) on the growth dynamics of Salmonella Typhimurium and Listeria monocytogenes. Experiments were carried out in general and minimal culture media at 3 equivalent concentration levels in terms of sweetness intensity (TS and LS at 3, 9 and 15% (w/v); St at 0...
January 18, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28124686/ligand-non-innocence-and-strong-correlation-in-manganese-superoxide-dismutase-mimics
#15
Alexandra R McIsaac, David A Mazziotti
We examine the 1-electron reduction of manganese porphyrin complexes Mn(iii) porphyrin and Mn(iii) TDE-2-ImP(5+), which have attracted recent interest due to their properties as superoxide dismutase mimics. We perform a series of electronic structure calculations using the variational 2-electron reduced density matrix (2-RDM) method with a large [30,30] active space that represents a wavefunction with 10(19) variables, as well as the more traditional complete active space self-consistent field (CASSCF) method with a [14,14] active space...
January 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28118417/pain-from-dental-implant-placement-inflammatory-pulpitis-pain-and-neuropathic-pain-present-different-somatosensory-profiles
#16
André Luís Porporatti, Leonardo Rigoldi Bonjardim, Juliana Stuginski-Barbosa, Estevam Augusto Bonfante, Yuri Martins Costa, Paulo César Rodrigues Conti
AIMS: To address the two following questions: (1) What kind of somatosensory abnormalities may be characterized in patients receiving dental implants (IMP), in ongoing inflammatory dental pulpitis (IP) patients, and in neuropathic pain (atypical odontalgia [AO]) patients? and (2) What sort of sensory and neural changes may result from dental implant placement surgery and pulpectomy? METHODS: A total of 60 subjects were divided into three groups: the IMP (n = 20), IP (n = 20), and AO groups (n = 20)...
January 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28114589/murine-corneal-inflammation-and-nerve-damage-after-infection-with-hsv-1-are-promoted-by-hvem-and-ameliorated-by-immune-modifying-nanoparticle-therapy
#17
Rebecca G Edwards, Sarah J Kopp, Igal Ifergan, Jr-Wen Shui, Mitchell Kronenberg, Stephen D Miller, Richard Longnecker
Purpose: To determine cellular and temporal expression patterns of herpes virus entry mediator (HVEM, Tnfrsf14) in the murine cornea during the course of herpes simplex virus 1 (HSV-1) infection, the impact of this expression on pathogenesis, and whether alterations in HVEM or downstream HVEM-mediated effects ameliorate corneal disease. Methods: Corneal HVEM levels were assessed in C57BL/6 mice after infection with HSV-1(17). Leukocytic infiltrates and corneal sensitivity loss were measured in the presence, global absence (HVEM knockout [KO] mice; Tnfrsf14-/-), or partial absence of HVEM (HVEM conditional KO)...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28110955/determination-of-inosine-5-monophosphate-dehydrogenase-activity-in-red-blood-cells-of-thiopurine-treated-patients-using-hplc
#18
Audrey Beringer, Antony Citterio-Quentin, Rebeca Obenza Otero, Clémence Gustin, Rebecca Clarke, Jean-Paul Salvi, Roselyne Boulieu
Thiopurine drugs are commonly used in immune diseases and to a lesser extent, in transplant rejection prophylaxis: however interindividual variability in drug response and in the occurrence of adverse events is observed. Genetic variation in thiopurine S-methyltransferase (TPMT) doesn't completely explain the occurrence of all adverse events and drug response variability. The potential implication of other enzymes involved in thiopurine metabolism, such as ITPA, has been investigated over the last decade but little data is available on inosine 5'-monophosphate dehydrogenase (IMPDH) in patients treated with thiopurine drugs...
February 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28100600/suitability-of-the-carbapenem-inactivation-method-cim-to-detect-imp-metallo-%C3%AE-lactamase-producing-enterobacteriaceae
#19
Kyoichi Saito, Ryuichi Nakano, Yuki Suzuki, Akiyo Nakano, Yoshihiko Ogawa, Shinsuke Yonekawa, Shiro Endo, Fumiko Mizuno, Kei Kasahara, Keiichi Mikasa, Mitsuo Kaku, Hisakazu Yano
Carbapenem-resistant Enterobacteriaceae (CRE) have become globally distributed in the past decade, resulting in concern over control of hospital infections and antimicrobial therapies (1. 2).….
January 18, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28098548/nosocomial-infections-with-imp-19-producing-pseudomonas-aeruginosa-linked-to-contaminated-sinks-france
#20
Lucie Amoureux, Karena Riedweg, Angélique Chapuis, Julien Bador, Eliane Siebor, André Péchinot, Marie-Lorraine Chrétien, Claire de Curraize, Catherine Neuwirth
We isolated IMP-19-producing Pseudomonas aeruginosa from 7 patients with nosocomial infections linked to contaminated sinks in France. We showed that blaIMP-19 was located on various class 1 integrons among 8 species of gram-negative bacilli detected in sinks: P. aeruginosa, Achromobacter xylosoxidans, A. aegrifaciens, P. putida, Stenotrophomonas maltophilia, P. mendocina, Comamonas testosteroni, and Sphingomonas sp.
February 2017: Emerging Infectious Diseases
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