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https://www.readbyqxmd.com/read/29223073/evidence-for-pain-attenuation-by-the-motor-system-based-judgment-of-agency
#1
N Karsh, O Goldstein, B Eitam
Pain is an integral part of our lives. Although the effect of 'control' on sensed pain has been extensively studied and discussed, recent findings seem to be at odds with the substantial evidence for a robust motor-based sensory attenuation effect - an indirect marker for one's sense of agency. The goal of the current study was to re-examine whether there is evidence for such an effect in the context of pain. In three experiments, human participants were aversively stimulated and the sensitivity of self-reported pain to factors previously shown to modulate the sensory attenuation effect was tested (control over parameters of the stimulation; temporal contiguity and predictability, and stimulation intensity)...
December 6, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/29219903/nursing-staff-perceptions-of-fall-risk-the-emergence-of-learned-helplessness-as-a-theme
#2
Terri Lea Gibson, Susan L Lloyd
Nurses and unlicensed assistive personnel on 2 medical-surgical units were asked about their perceptions regarding patient falls. Their responses reflect learned helplessness and a lack of nurse empowerment that are relevant findings as nurse executives work to decrease patient falls.
January 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29219874/experiences-of-community-dwelling-older-adults-with-the-use-of-telecare-in-home-care-services-a-qualitative-systematic-review
#3
Cecilie Karlsen, Mette Spliid Ludvigsen, Carl Erik Moe, Kristin Haraldstad, Elin Thygesen
BACKGROUND: The aging population will lead to a rise in the number of people with age-related diseases, and increasing demand for home care services. Telecare is seen as a solution to this challenge by promoting aging in place. Nevertheless, there is still a poor understanding of older adults' experiences with the actual use of telecare. OBJECTIVE: The aim of this review was to identify and synthesize the best available qualitative evidence of community-dwelling older adults' experience with the use of telecare in home care services...
December 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29216210/social-relationship-changes-in-victim-families-due-to-a-social-disaster-experiences-of-student-victims-families-in-the-south-korean-sewol-ferry-disaster
#4
Sun Mi Cho, Ansuk Jeong, Jung Hee Ha, Eun Young Kim
The Sewol ferry incident on April 16, 2014 in South Korea claimed the lives of 304 individuals, including about 250 high school students on a school trip. The majority of South Korean citizens were watching live updates on the capsized Sewol ferry, anxiously watching on TV how the vessel fully sunk over time. They were desperately hoping for the rescue of the survivors inside. However, their anxiety had become shock, anger, and helplessness, and the disaster has become a daunting, collective trauma, not just to the victims and their families, but also to the citizens who were exposed only through the media...
2017: PloS One
https://www.readbyqxmd.com/read/29215794/immigrant-nurses-perceptions-on-cultural-differences-based-job-concerns-a-phenomenological-study-in-shanghai-china
#5
Hai-Ping Yu, You-Qing Peng, Yun-Ying Hung, Lin Zhou
AIMS AND OBJECTIVES: To explore the experiences of immigrant nurses working in Shanghai, China. BACKGROUND: With the development of China, population growth has been accelerating. Simultaneously, the number of immigrant nurses in Shanghai has been increasing dramatically. Meanwhile, their turnover rate is abnormally high, primarily because of job concerns stemming from cultural differences. An understanding of immigrant nurses' job concerns caused by cultural differences can be used to help them to work more efficiently and cohesively...
December 7, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29201122/quasi-experimental-effectiveness-of-cognitive-behavioral-therapy-on-reliving-migraine-headaches-in-migraine-sufferers
#6
Hosein Ebrahimi Moghadam, Ahoo Karimi, Kimia Seifi
Objective: This study aimed to investigate the effectiveness of cognitive-behavioral therapy on relieving migraine headaches in migraine sufferers. Materials & Methods: In this quasi-experimental study with pre-test and post-test method, the samples were outpatients of public hospitals in Ilam City, southwestern Iran since May-Jul 2010. They were selected based on inclusion and exclusion criteria, and divided into experimental and control groups. The data were analyzed using SPSS ver...
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29193999/nursing-and-the-emergence-of-egoless-care-a-discussion-on-social-engineering-in-mental-health
#7
Gert Schout, Gideon de Jong
The narrowing of the diverse fields of psychiatry to just the single dimension of the biomedical model has resulted in a situation where professions with a focus on curing (psychiatrists and psychologists) are favoured over those with a focus on caring and encouraging near communities to care for each other (nurses). The social engineering of mental problems leads to a state of helplessness. This paper contributes to an understanding of the barriers to utilise the social resources of people with mental health problems and argues for forms of "indirect social engineering" and "egoless care," and, ultimately, a rediscovery of nursing, using the mental health care in the Netherlands as a case study...
December 1, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/29180805/a-fast-approach-to-detect-gene-gene-synergy
#8
Pengwei Xing, Yuan Chen, Jun Gao, Lianyang Bai, Zheming Yuan
Selecting informative genes, including individually discriminant genes and synergic genes, from expression data has been useful for medical diagnosis and prognosis. Detecting synergic genes is more difficult than selecting individually discriminant genes. Several efforts have recently been made to detect gene-gene synergies, such as dendrogram-based I(X 1; X 2; Y) (mutual information), doublets (gene pairs) and MIC(X 1; X 2; Y) based on the maximal information coefficient. It is unclear whether dendrogram-based I(X 1; X 2; Y) and doublets can capture synergies efficiently...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29180675/protein-kinase-m%C3%AE-in-medial-prefrontal-cortex-mediates-depressive-like-behavior-and-antidepressant-response
#9
W Yan, J-F Liu, Y Han, W Zhang, Y-X Luo, Y-X Xue, W-L Zhu, C Yang, W-H Chen, H-L Guo, Y-N Ma, K Yuan, J-S Wang, J Shi, L Lu
Neuronal atrophy and alterations of synaptic structure and function in the medial prefrontal cortex (mPFC) have been implicated in the pathogenesis of depression, but the underlying molecular mechanisms are largely unknown. The protein kinase Mζ (PKMζ), a brain-specific atypical protein kinase C isoform, is important for maintaining long-term potentiation and storing memory. In the present study, we explored the role of PKMζ in mPFC in two rat models of depression, chronic unpredictable stress (CUS) and learned helplessness...
November 28, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29175713/lateral-habenula-in-the-pathophysiology-of-depression
#10
REVIEW
Yan Yang, Hao Wang, Ji Hu, Hailan Hu
Depression is a devastating disorder with a combination of diverse symptoms such as low self-esteem, lack of motivation, anhedonia, loss of appetite, low energy, and discomfort without a clear cause. Depression has been suggested to be the result of maladaptive changes in specific brain circuits. Recently, the lateral habenula (LHb) has emerged as a key brain region in the pathophysiology of depression. Increasing evidence from rodent, non-human primate and human studies indicates that the aberrant activity of the LHb is associated with depressive symptoms such as helplessness, anhedonia, and excessive negative focus...
November 23, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29174736/protein-kinase-a-mediates-scopolamine-induced-mtor-activation-and-an-antidepressant-response
#11
Jianyang Dong, Qinji Zhou, Zhisheng Wei, Shi Yan, Fangfang Sun, Xiang Cai
BACKGROUND: Clinical reports have shown that scopolamine produces a rapid (3-4 d) and potent anti-depressive response without severe adverse effects. Animal experiments have proven that scopolamine induces mTOR pathway activation in an AMPAR dependent manner. The present study aimed to determine the role of PKA in scopolamine-induced potentiation of AMPAR, as well as in mTOR pathway activation and rapid antidepressant effects. METHODS: We utilized electrophysiological recording, Western blotting, and behavior tests to examine the effects of scopolamine, the selective M2 cholinergic receptor antagonist methoctramine, and H89, a PKA specific inhibitor on AMPAR potentiation, mTOR pathway activation, and behavioral responses in a rat depression model of learned helplessness...
November 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29168380/quantitative-study-of-oligomerization-of-yeast-prion-sup35nm-proteins
#12
Yanjing Wang, Chi Wu
The fibrillation of misfolded neurodegenerative diseases related proteins has been extensively studied in the last few decades, but the initial oligomerization has been rarely touched even though some recent evidences indicated that small protein oligomers are more neurotoxic than long protein fibers. It is rather difficult to study the initial oligomerization (nucleation) because most of experimental methods, such as β-sheet related fluorescence assay and X-ray diffraction, are helpless in detecting small structure-less protein oligomers...
November 23, 2017: Biochemistry
https://www.readbyqxmd.com/read/29166647/the-reciprocal-relations-between-experiential-avoidance-school-stressor-and-psychological-stress-response-among-japanese-adolescents
#13
Kenichiro Ishizu, Yoshiyuki Shimoda, Tomu Ohtsuki
The present study aimed to investigate the reciprocal relations between experiential avoidance, stressor, and psychological stress response (which consist of anger, depression, anxiety, helplessness, and physical complaints). In this study, 688 Japanese junior high school students (353 boys, 334 girls, 1 unidentified; mean age 13.28 years) completed three waves of questionnaires on experiential avoidance, stressor, and psychological stress response, with one-week intervals between measurement waves. Results from cross-lagged panel analyses showed that experiential avoidance predicted subsequent stressor and psychological stress response...
2017: PloS One
https://www.readbyqxmd.com/read/29162061/medical-student-attitudes-and-educational-interventions-to-prevent-neurophobia-a-longitudinal-study
#14
Lisa Shiels, Pratish Majmundar, Aleksander Zywot, John Sobotka, Christine S M Lau, Tuula O Jalonen
BACKGROUND: With an aging American population, the burden of neurologic disease is intensifying and the decline in neurology residents and practicing neurologists is leaving these patients helpless and unable to find care. 'Neurophobia', a chronic illness that begins early in medical school, has been identified as a cause for the low number of neurology residents. METHODS: A longitudinal study surveyed medical students at the beginning of their first year (M1) and then again at the beginning of their second year (M2)...
November 21, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29155993/lack-of-antidepressant-effects-of-2r-6r-hydroxynorketamine-in-a-rat-learned-helplessness-model-comparison-with-r-ketamine
#15
Yukihiko Shirayama, Kenji Hashimoto
Background: (R)-Ketamine exhibits rapid and sustained antidepressant effects in animal models of depression. It is stereoselectively metabolized to (R)-norketamine, and subsequently to (2R,6R)-hydroxynorketamine (HNK) in the liver. The metabolism of ketamine to HNK was recently demonstrated to be essential for ketamine's antidepressant actions. However, no study has compared the antidepressant effects of these three compounds in animal models of depression. Methods: The effects of a single intraperitoneal injection of (R)-ketamine, (R)-norketamine, and (2R,6R)-HNK in a rat learned helplessness (LH) model were examined...
November 15, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29151391/repeated-treatment-with-nitric-oxide-synthase-inhibitor-attenuates-learned-helplessness-development-in-rats-and-increases-hippocampal-bdnf-expression
#16
Laura Alves Stanquini, Caroline Biojone, Francisco Silveira Guimarães, Sâmia Regiane Joca
BACKGROUND: Nitric oxide synthase (NOS) inhibitors induce antidepressant-like effects in animal models sensitive to acute drug treatment such as the forced swimming test. However, it is not yet clear if repeated treatment with these drugs is required to induce antidepressant-like effects in preclinical models. OBJECTIVE: The aim of this study was to test the effect induced by acute or repeated (7 days) treatment with 7-nitroindazole (7-NI), a preferential inhibitor of neuronal NOS, in rats submitted to the learned helplessness (LH) model...
November 20, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29132340/what-do-japanese-residents-learn-from-treating-dying-patients-the-implications-for-training-in-end-of-life-care
#17
Kazuko Arai, Takuya Saiki, Rintaro Imafuku, Chihiro Kawakami, Kazuhiko Fujisaki, Yasuyuki Suzuki
BACKGROUND: How medical residents' experiences with care for dying patients affect their emotional well-being, their learning outcomes, and the formation of their professional identities is not fully understood. We examine residents' emotional states and learning occurring during the provision of care to dying patients and specifically discuss the impact of providing end-of-life (EOL) care on professional identity formation. METHODS: Semi-structured interviews were conducted with 13 residents who had graduated in the last 3 to 5 years...
November 13, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29122005/memories-of-paternal-relations-are-associated-with-coping-and-defense-mechanisms-in-breast-cancer-patients-an-observational-study
#18
Chiara Renzi, Giada Perinel, Paola Arnaboldi, Sara Gandini, Valeria Vadilonga, Nicole Rotmensz, Angela Tagini, Florence Didier, Gabriella Pravettoni
BACKGROUND: Breast cancer diagnosis and treatment represent stressful events that demand emotional adjustment, thus recruiting coping strategies and defense mechanisms. As parental relations were shown to influence emotion regulation patterns and adaptive processes in adulthood, the present study investigated whether they are specifically associated to coping and defense mechanisms in patients with breast cancer. METHODS: One hundred and ten women hospitalized for breast cancer surgery were administered questionnaires assessing coping with cancer, defense mechanisms, and memories of parental bonding in childhood...
November 9, 2017: BMC Psychology
https://www.readbyqxmd.com/read/29121889/prevalence-and-associated-factors-of-medication-non-adherence-in-hematological-oncological-patients-in-their-home-situation
#19
Linda Bouwman, Corien M Eeltink, Otto Visser, Jeroen J W M Janssen, Jolanda M Maaskant
BACKGROUND: Medication non-adherence is associated with poor health outcomes and increased health care costs. Depending on definitions, reported non-adherence rates in cancer patients ranges between 16 and 100%, which illustrates a serious problem. In malignancy, non-adherence reduces chances of achievement of treatment response and may thereby lead to progression or even relapse. Except for Chronic Myeloid Leukemia (CML), the extent of non-adherence has not been investigated in hematological-oncological patients in an outpatient setting...
November 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29119264/keap1-nrf2-signaling-pathway-confers-resilience-versus-susceptibility-to-inescapable-electric-stress
#20
Ji-Chun Zhang, Wei Yao, Chao Dong, Mei Han, Yukihiko Shirayama, Kenji Hashimoto
The transcription factor Keap1-Nrf2 signaling plays a key role in the oxidative stress which is involved in psychiatric disorders. In the learned helplessness (LH) paradigm, protein levels of Keap1 and Nrf2 in the prefrontal cortex and dentate gyrus of hippocampus from LH (susceptible) rats were lower than control and non-LH (resilience) rats. Furthermore, protein expressions of Keap1 and Nrf2 in the parietal cortex from major depressive disorder, schizophrenia, and bipolar disorder were lower than controls...
November 8, 2017: European Archives of Psychiatry and Clinical Neuroscience
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