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https://www.readbyqxmd.com/read/29332311/otolaryngology-head-and-neck-region-manifestations-of-brucella
#1
Anna Lazutkin, Maya Korem, Jeffrey M Weinberger, Ron Eliashar, Nir Hirshoren
OBJECTIVES/HYPOTHESIS: Patients with Brucella infection present with nonspecific symptoms originating from different organs. In this study, we investigated the manifestations involving principally the otolaryngology/head and neck region. STUDY DESIGN: Retrospective cohort chart review. METHODS: A retrospective analysis of patients diagnosed with brucellosis in a tertiary medical center. Medical records of 55 patients treated for positive Brucella blood cultures between 2007 and 2016 were analyzed...
January 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29332249/correlation-of-flow-density-as-measured-using-optical-coherence-tomography-angiography-with-structural-and-functional-parameters-in-glaucoma-patients
#2
Maged Alnawaiseh, Larissa Lahme, Viktoria Müller, André Rosentreter, Nicole Eter
PURPOSE: To evaluate the correlation between flow density, as measured by optical coherence tomography angiography (OCTA), and structural and functional parameters in patients with open-angle glaucoma. METHODS: Thirty-four eyes of 34 patients with open-angle glaucoma and 35 eyes of 35 healthy subjects were prospectively included in this study. OCTA was performed using RTVue XR Avanti with AngioVue. The macula was imaged with a 3 × 3 mm scan and the optic nerve head (ONH) with a 4...
January 13, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29332187/human-bite-injuries-to-the-head-and-neck-current-trends-and-management-protocols-in-england-and-wales
#3
Glyndwr W Jenkins, Robert Isaac, Shakir Mustafa
INTRODUCTION: Human bite injuries can be challenging in their presentation to the examining physician. In a study by Merchant et al., 18% of patients presenting with a human bite injury had suffered wounds to the head and neck region. Current trends in their initial management at presentation to emergency departments throughout England and Wales will be discussed in this paper. MATERIALS AND METHOD: A postal survey was sent out to 100 A&E lead clinicians. This was followed up by telephone enquiries to improve the response rate...
January 14, 2018: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29332130/cerebrospinal-fluid-pressure-revisiting-factors-influencing-optic-nerve-head-biomechanics
#4
Yi Hua, Andrew P Voorhees, Ian A Sigal
Purpose: To model the sensitivity of the optic nerve head (ONH) biomechanical environment to acute variations in IOP, cerebrospinal fluid pressure (CSFP), and central retinal artery blood pressure (BP). Methods: We extended a previously published numerical model of the ONH to include 24 factors representing tissue anatomy and mechanical properties, all three pressures, and constraints on the optic nerve (CON). A total of 8340 models were studied to predict factor influences on 98 responses in a two-step process: a fractional factorial screening analysis to identify the 16 most influential factors, followed by a response surface methodology to predict factor effects in detail...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29332119/autofluorescence-of-skin-advanced-glycation-end-products-as-a-risk-factor-for-open-angle-glaucoma-the-alienor-study
#5
Cedric Schweitzer, Audrey Cougnard-Gregoire, Vincent Rigalleau, Jean-Francois Dartigues, Florence Malet, Marie-Benedicte Rougier, Marie-Noelle Delyfer, Catherine Helmer, Jean-Francois Korobelnik, Cecile Delcourt
Purpose: To analyze the association between skin autofluorescence (sAF), estimating tissue accumulation of advanced glycation end-products (AGEs), and open angle glaucoma (OAG) in an elderly population. Methods: The Antioxydants, Lipides Essentiels, Nutrition and maladies OculaiRes (ALIENOR) study is an on-going epidemiologic population-based study on age-related eye diseases. In 2009 to 2010, 624 subjects, aged 74 years or older, were recruited. All subjects underwent a complete eye examination, including optic disc color photography and spectral-domain optical coherence tomography (SD-OCT) examination...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29331949/bibliometric-analysis-of-military-trauma-publications-2000-2016
#6
Mark L Vickers, C P Coorey, G J Milinovich, L Eriksson, M Assoum, M C Reade
INTRODUCTION: Bibliometric tools can be used to identify the authors, topics and research institutions that have made the greatest impact in a field of medicine. The aim of this research was to analyse military trauma publications over the last 16 years of armed conflict in order to highlight the most important lessons that have translated into civilian practice and military doctrine as well as identify emerging areas of importance. METHODS: A systematic search of research published between January 2000 and December 2016 was conducted using the Thompson Reuters Web of Science database...
January 13, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29331751/comprehensive-genomic-profiling-of-head-and-neck-squamous-cell-carcinoma-reveals-fgfr1-amplifications-and-tumour-genomic-alterations-burden-as-prognostic-biomarkers-of-survival
#7
C Dubot, V Bernard, M P Sablin, S Vacher, W Chemlali, A Schnitzler, G Pierron, K Ait Rais, N Bessoltane, E Jeannot, J Klijanienko, O Mariani, T Jouffroy, V Calugaru, C Hoffmann, M Lesnik, N Badois, F Berger, C Le Tourneau, M Kamal, I Bieche
BACKGROUND: We aimed at identifying deleterious genomic alterations from untreated head and neck squamous cell carcinoma (HNSCC) patients, and assessing their prognostic value. PATIENTS AND METHODS: We retrieved 122 HNSCC patients who underwent primary surgery. Targeted NGS was used to analyse a panel of 100 genes selected among the most frequently altered genes in HNSCC and potential therapeutic targets. We selected only deleterious (activating or inactivating) single nucleotide variations, and copy number variations for analysis...
January 10, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29331747/dural-based-cavernous-malformation-at-the-cerebral-convexity-report-of-two-pediatric-patients
#8
Guichen Li, Xuan Zhai, Yang Zhang, Ping Liang, Xuanxuan Wu, Kun Hou
BACKGROUND: Intracranial (cavernous malformations) CMs are usually located at the cerebral parenchyma, dural-based CMs outside the middle fossa are rarely reported. To our knowledge, dural-based CMs located at the cerebral convexity are even rarer that only two pediatric cases were ever reported. In this report, we present two extremely rare cases of dural-based CMs at the cerebral convexity in pediatric patients. The clinical course, radiological and pathological features, treatment, and follow-up are described...
January 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29331540/plant-flowering-imposing-dna-specificity-on-histone-fold-subunits
#9
REVIEW
Nerina Gnesutta, Roberto Mantovani, Fabio Fornara
CONSTANS (CO) is a master regulator of flowering time, although the mechanisms underlying its role as a transcriptional regulator are not well understood. The DNA-binding domain of CO shares homology with that of NUCLEAR FACTOR YA (NF-YA), a subunit of the CCAAT-binding trimer NF-Y. Recent publications indicate that CO and its rice homolog HEADING DATE 1 (Hd1) form heterotrimers with the histone-fold subunits of NF-Y to efficiently bind promoter elements in the florigen genes. Differences in the DNA-binding specificities of NF-Y and NF-CO can be conceptualized based on our knowledge of the 3D structure of the NF-Y/CCAAT complex...
January 10, 2018: Trends in Plant Science
https://www.readbyqxmd.com/read/29331491/investigating-the-relationship-between-cardiac-interoception-and-autonomic-cardiac-control-using-a-predictive-coding-framework
#10
Andrew P Owens, Karl J Friston, David A Low, Christopher J Mathias, Hugo D Critchley
Predictive coding models, such as the 'free-energy principle' (FEP), have recently been discussed in relation to how interoceptive (afferent visceral feedback) signals update predictions about the state of the body, thereby driving autonomic mediation of homeostasis. This study appealed to 'interoceptive inference', under the FEP, to seek new insights into autonomic (dys)function and brain-body integration by examining the relationship between cardiac interoception and autonomic cardiac control in healthy controls and patients with forms of orthostatic intolerance (OI); to (i) seek empirical support for interoceptive inference and (ii) delineate if this relationship was sensitive to increased interoceptive prediction error in OI patients during head-up tilt (HUT)/symptom provocation...
January 9, 2018: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29331456/vocalization-as-an-indicator-of-estrus-climax-in-holstein-heifers-during-natural-estrus-and-superovulation
#11
Volker Röttgen, Frank Becker, Armin Tuchscherer, Christine Wrenzycki, Sandra Düpjan, Peter C Schön, Birger Puppe
The reliable detection of estrus is an important scientific and practical challenge in dairy cattle farming. Female vocalization may indicate reproductive status, and preliminary evidence suggests that this information can be used to detect estrus in dairy cattle. The aim of this study was to associate the changes in the vocalization rate of dairy heifers with behavioral estrus indicators as well as test the influence of the type of estrus (natural estrus vs. superovulation-induced estrus). We analyzed 6 predefined estrus-related behavior patterns (standing to be mounted, head-side mounting, active mounting, chin resting, being mounted while not standing, and active sniffing in the anogenital region) and vocalization rates in the peri-estrus period (day of estrus ± 1 d) of 12 German Holstein heifers using audio-visual recordings...
January 10, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29331449/quantifying-axonal-responses-in-patient-specific-models-of-subthalamic-deep-brain-stimulation
#12
Kabilar Gunalan, Bryan Howell, Cameron C McIntyre
Medical imaging has played a major role in defining the general anatomical targets for deep brain stimulation (DBS) therapies. However, specifics on the underlying brain circuitry that is directly modulated by DBS electric fields remain relatively undefined. Detailed biophysical modeling of DBS provides an approach to quantify the theoretical responses to stimulation at the cellular level, and has established a key role for axonal activation in the therapeutic mechanisms of DBS. Estimates of DBS-induced axonal activation can then be coupled with advances in defining the structural connectome of the human brain to provide insight into the modulated brain circuitry and possible correlations with clinical outcomes...
January 10, 2018: NeuroImage
https://www.readbyqxmd.com/read/29331306/primary-mucinous-eccrine-carcinoma-of-the-buccal-space-a-case-report-and-review-of-the-literature
#13
Kirkland N Lozada, Muhammed S Qazi, Azita S Khorsandi, Raymond L Chai
IMPORTANCE: Mucinous eccrine carcinoma is a rare entity that most commonly affects the head and neck. Due to its low frequency of occurrence, review of its etiology, histopathology, and treatment strategies is beneficial to all clinicians who may encounter similar appearing masses. OBSERVATION: An 84-year-old male presented with a blue mass on the left cheek. This mass started as a small bump and grew significantly over one year. His primary care physician monitored its growth and ultimately referred to an otolaryngologist...
January 5, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29331230/lower-limb-articular-scaling-and-body-mass-estimation-in-pliocene-and-pleistocene-hominins
#14
Christopher B Ruff, M Loring Burgess, Nicole Squyres, Juho-Antti Junno, Erik Trinkaus
Previous attempts to estimate body mass in pre-Holocene hominins have relied on prediction equations derived from relatively limited extant samples. Here we derive new equations to predict body mass from femoral head breadth and proximal tibial plateau breadth based on a large and diverse sample of modern humans (avoiding the problems associated with using diaphyseal dimensions and/or cadaveric reference samples). In addition, an adjustment for the relatively small femoral heads of non-Homo taxa is developed based on observed differences in hip to knee joint scaling...
January 10, 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29331217/the-cost-of-perioperative-complications-following-pancreaticoduodenectomy-a-systematic-review
#15
REVIEW
Jason Wang, Ronald Ma, Leonid Churilov, Paul Eleftheriou, Mehrdad Nikfarjam, Christopher Christophi, Laurence Weinberg
BACKGROUND/OBJECTIVES: Pancreaticoduodenectomy (PD), also known as a Whipple procedure, is commonly performed for a variety of benign and malignant tumours, including of the pancreatic head and surrounding structures. PD is associated with low mortality but high morbidity and costs. Our objective was to describe the financial burden of complications following pancreaticoduodenectomy. METHODS: We searched for articles using the MEDLINE, EMBASE, Cochrane and EconLit databases from the year 2000...
December 19, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29331210/to-roll-the-eyes-and-snap-a-bite-function-development-and-evolution-of-craniofacial-muscles
#16
REVIEW
Frank R Schubert, Arun J Singh, Oluwatomisin Afoyalan, Chrissa Kioussi, Susanne Dietrich
Craniofacial muscles, muscles that move the eyes, control facial expression and allow food uptake and speech, have long been regarded as a variation on the general body muscle scheme. However, evidence has accumulated that the function of head muscles, their developmental anatomy and the underlying regulatory cascades are distinct. This article reviews the key aspects of craniofacial muscle and muscle stem cell formation and discusses how this differs from the trunk programme of myogenesis; we show novel RNAseq data to support this notion...
January 10, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29331076/submental-artery-island-flap-with-simultaneous-level-i-neck-dissection
#17
Antoine Eskander, Daniel Strigenz, Nolan Seim, Enver Ozer
BACKGROUND: The purpose of this study was to illustrate the submental island flap elevation technique with simultaneous level I neck dissection followed by the inset and reconstruction of an oropharyngeal defect. METHODS: A 63-year-old patient with a T2N1M0 human papillomavirus-positive squamous cell carcinoma of the tonsil was treated with concurrent chemoradiotherapy (cisplatin + 66 Gy). A local recurrence 2.5 years after treatment was treated surgically and reconstructed with a submental island flap...
January 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29331056/exploring-the-advantages-of-multiband-fmri-with-simultaneous-eeg-to-investigate-coupling-between-gamma-frequency-neural-activity-and-the-bold-response-in-humans
#18
Makoto Uji, Ross Wilson, Susan T Francis, Karen J Mullinger, Stephen D Mayhew
We established an optimal combination of EEG recording during sparse multiband (MB) fMRI that preserves high-resolution, whole-brain fMRI coverage while enabling broad-band EEG recordings which are uncorrupted by MRI gradient artefacts (GAs). We first determined the safety of simultaneous EEG recording during MB fMRI. Application of MB factor = 4 produced <1°C peak heating of electrode/hardware during 20 min of GE-EPI data acquisition. However, higher SAR sequences require specific safety testing, with greater heating observed using PCASL with MB factor = 4...
January 13, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29331048/dog-bites-in-a-us-county-age-body-part-and-breed-in-pediatric-dog-bites
#19
Sriram Ramgopal, Lauren Bealafeld Brungo, Michael Bykowski, Raymond Pitetti, Robert Hickey
AIM: To compare characteristics of gender, age, body part, and breed in dog bites. METHODS: We reviewed 14,956 dog bites (4,195 pediatric) reported to the Allegehny County Health Department, USA, between 2007-2015. Using pre-defined age groups, we performed linear regression to assess for subject age and bite frequency and used binary logistic regression to evaluate for differences in gender and body part and chi-squared tests with Bonferroni correction to evaluate for differences in reported breeds with age...
January 13, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29330962/skin-conformal-polymer-electrodes-for-clinical-ecg-and-eeg-recordings
#20
Flurin Stauffer, Moritz Thielen, Christina Sauter, Séverine Chardonnens, Simon Bachmann, Klas Tybrandt, Christian Peters, Christofer Hierold, Janos Vörös
Preparation-free and skin compliant biopotential electrodes with high recording quality enable wearables for future healthcare and the Internet of Humans. Here, super-soft and self-adhesive electrodes are presented for use on dry and hairy skin without skin preparation or attachment pressure. The electrodes show a skin-contact impedance of 50 kΩ cm2 at 10 Hz that is comparable to clinical standard gel electrodes and lower than existing dry electrodes. Microstructured electrodes inspired by grasshopper feet adhere repeatedly to the skin with a force of up to 0...
January 13, 2018: Advanced Healthcare Materials
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