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https://www.readbyqxmd.com/read/29332813/fast-and-easy-extraction-of-antidepressants-from-whole-blood-using-ionic-liquids-as-extraction-solvent
#1
Marieke De Boeck, Lisa Dubrulle, Wim Dehaen, Jan Tytgat, Eva Cuypers
This study aims to prove that ionic liquids (ILs) can be used as extraction solvents in a liquid-liquid microextraction, coupled to LC-MS/MS, for the quantification of a large group of antidepressants in whole blood samples. The sample preparation procedure consisted of adding 1.0mL aqueous buffer pH 3.0 and 60µL of IL (1-butyl-3-methylimidazolium hexafluorophosphate) to 1.0mL whole blood. Subsequently, a 5-min rotary mixing step was performed followed by centrifugation. The lower IL phase was collected, diluted 1:10 in methanol and 10µL was injected into the LC-MS/MS...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29277371/repeated-fluvoxamine-treatment-recovers-early-postnatal-stress-induced-hypersociability-like-behavior-in-adult-rats
#2
Haruko Kumamoto, Taku Yamaguchi, Kohtarou Konno, Takeshi Izumi, Takayuki Yoshida, Yu Ohmura, Masahiko Watanabe, Mitsuhiro Yoshioka
Childhood maltreatment is associated with impaired adult brain function, particularly in the hippocampus, and is not only a major risk factor for some psychiatric diseases but also affects early social development and social adaptation in later life. The aims of this study were to determine whether early postnatal stress affects social behavior and whether repeated fluvoxamine treatment reverses these changes. Rat pups were exposed to footshock stress during postnatal days 21-25 (at 3 weeks old: 3wFS). During the post-adolescent period (10-14 weeks postnatal), the social interaction test and Golgi-cox staining of dorsal hippocampal pyramidal neurons were performed...
December 9, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29200003/effects-of-the-antidepressants-desipramine-and-fluvoxamine-on-latency-to-immobility-and-duration-of-immobility-in-the-forced-swim-test-in-adult-male-c57bl-6j-mice
#3
Wouter Koek, Thomas L Sandoval, Lynette C Daws
The forced swim test in rodents allows rapid detection of substances with antidepressant-like activity, evidenced as a decreased duration of immobility that is produced by the majority of clinically used antidepressants. Antidepressants also increase the latency to immobility, and this additional measure reportedly can increase the sensitivity of the forced swim test in mice. Extending these findings, the present study examined the effects of desipramine and fluvoxamine in a forced swim test in C57BL/6J mice, a strain commonly used as background for genetic modifications, analyzing results with a method (i...
December 1, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29155491/variation-in-the-response-of-clozapine-biotransformation-pathways-in-human-hepatic-microsomes-to-cyp1a2-and-cyp3a4-selective-inhibitors
#4
Michael Murray, Wei V Zhang, Robert J Edwards
The atypical antipsychotic agent clozapine (CLZ) is effective in many patients who are resistant to conventional antipsychotic drugs. Cytochromes P450 (CYPs) 1A2 and 3A4 oxidise CLZ to norCLZ and CLZ N-oxide in human liver. Concurrent treatment with inducers and inhibitors of CYP1A2 modulates CLZ elimination that disrupts therapy. Drug-drug interactions involving CYP3A4 are also significant but less predictable. To further characterise the factors underlying these interactions, we used samples from a cohort of human livers to assess variation in CLZ oxidation pathways in relation to intrinsic CYP3A4 and CYP1A2 activities and the effects of the corresponding selective inhibitors ketoconazole (0...
November 20, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29148163/development-and-validation-of-a-high-performance-liquid-chromatography-method-for-determination-of-lisinopril-in-human-plasma-by-magnetic-solid-phase-extraction-and-pre-column-derivatization
#5
Noushin Rastkari, Reza Ahmadkhaniha
A sensitive, reliable and simple HPLC method was developed for the determination of lisinopril in human plasma. The method consists of extraction and clean-up steps based on magnetic solid-phase extraction and pre-column derivatization with a fluorescent reagent. The mobile phase consisted of a mixture of methanol-sodium dihydrogen phosphate (pH 3.0; 0.005 m; 75:25, v/v). The flow rate was set at 0.7 mL/min. Fluorescence detection was performed at 470nm excitation and 530nm emission wavelengths. Total chromatography run time was 5 min...
November 16, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29138569/post-marketing-observational-program-of-the-effectiveness-of-fluvoxamine-for-the-treatment-of-depression-in-patients-with-neurological-disorders-the-friends-study
#6
Nikolay N Yahno, Anastasia V Fedotova
In a prospective, non-blinded, uncontrolled, multicenter, post-marketing, observational study (FRIENDS; NCT02043197), fluvoxamine (50-300 mg/day for 90 days) was effective for the treatment of depression in 299 adult patients (age ≥18 years) with neurological disorders at baseline. The therapeutic effect of fluvoxamine was measured by means of changes in the Hospital Anxiety and Depression Scale depression and anxiety scores (HADS-D and HADS-A, respectively), global severity of illness, and clinical condition (measured using the Clinical Global Improvement [CGI] scale)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29101463/a-drug-drug-interaction-study-to-assess-the-effect-of-the-cyp1a2-inhibitor-fluvoxamine-on-the-pharmacokinetics-of-dovitinib-tki258-in-patients-with-advanced-solid-tumors
#7
Vincent A de Weger, Sanjay Goel, Roger von Moos, Jan H M Schellens, Nicholas Mach, Eugene Tan, Suraj Anand, Jeffrey W Scott, Ulrik Lassen
PURPOSE: Dovitinib is an orally available multi tyrosine kinase inhibitor which inhibits VEGFR 1-3, FGFR 1-3, and PDGFR. This study was performed to investigate the potential drug-drug interaction of dovitinib with the CYP1A2 inhibitor fluvoxamine in patients with advanced solid tumors. METHODS: Non-smoking patients of ≥ 18 years with advanced solid tumors, excluding breast cancer, were included. Patients were treated with a dose of 300 mg in 5 days on/2 days off schedule...
November 3, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29062366/comparison-of-saffron-and-fluvoxamine-in-the-treatment-of-mild-to-moderate-obsessive-compulsive-disorder-a-double-blind-randomized-clinical-trial
#8
Sophia Esalatmanesh, Mojtaba Biuseh, Ahmad Ali Noorbala, Seyed-Ali Mostafavi, Farzin Rezaei, Bita Mesgarpour, Payam Mohammadinejad, Shahin Akhondzadeh
Objective: There are different pathophysiological mechanisms for obsessive- compulsive disorder (OCD) as suggested by the serotonergic, dopaminergic, and glutamatergic hypotheses. The present study aimed at comparing the efficacy and safety of saffron (stigma of Crocus sativus) and fluvoxamine in the treatment of mild to moderate obsessive- compulsive disorder. Method: In this study, 50 males and females, aged 18 to 60 years, with mild to moderate OCD, participated. The patients were randomly assigned to receive either saffron (30 mg/day, 15 mg twice a day) or fluvoxamine (100 mg/day) for 10 weeks...
July 2017: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/29045303/riluzole-serum-concentration-in-pediatric-patients-treated-for-obsessive-compulsive-disorder
#9
Paul Grant, Cristan Farmer, Jane Song, Timothy Kish, Susan Swedo
PURPOSE/BACKGROUND: The goals of this study were to determine whether pediatric serum concentration of riluzole is similar to that observed in adults and to determine whether riluzole serum concentration is associated with adverse effects or efficacy in children and adolescents with treatment-refractory obsessive-compulsive disorder. METHODS/PROCEDURES: Data were drawn from previously published studies: 1 open-label trial and 1 randomized controlled trial with an open-label extension phase...
December 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29035919/attenuation-of-compulsive-like-behavior-by-fluvoxamine-in-a-non-induced-mouse-model-of-obsessive-compulsive-disorder
#10
Swarup Mitra, Abel Bult-Ito
The current study evaluated the role of strain and compulsive trait differences in response to fluvoxamine, a common obsessive-compulsive disorder (OCD) drug, in two different mouse strains (BIG1 and BIG2) with a spontaneous compulsive-like phenotype. For compulsive-like nest-building behavior, dose-dependent attenuation of nesting by fluvoxamine was observed for the BIG1 compulsive-like strain during the first hour after administration. No significant differences were found for the BIG2 strain during the first hour, although a dose-dependent trend similar to that in the BIG1 strain was observed...
October 13, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29033248/use-of-oral-antidepressants-in-patients-with-chronic-pruritus-a-systematic-review
#11
Tessa A Kouwenhoven, Peter C M van de Kerkhof, Marijke Kamsteeg
BACKGROUND: Chronic pruritus is a common skin symptom with marked impact on quality of life. Adequate treatment can be challenging for clinicians, demanding the exploration of new treatment options such as oral antidepressants. OBJECTIVE: To evaluate the use of oral antidepressants in chronic pruritus by a systematic overview of the available relevant literature. METHODS: The PubMed, EMBASE, Cochrane, and Web of Science databases were searched...
October 12, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28993551/usefulness-of-two-compartment-model-assisted-and-static-overall-inhibitory-activity-method-for-prediction-of-drug-drug-interaction
#12
Katsumi Iga, AKiko Kiriyama
Our study of drug-drug interaction (DDI) started with the clarification of unusually large DDI observed between ramelteon (RAM) and fluvoxamine (FLV). The main cause of this DDI was shown to be the extremely small hepatic availability of RAM (vFh). Traditional DDI prediction assuming the well-stirred hepatic extraction kinetic ignores the relative increase of vFh by DDI, while we could solve this problem by use of the tube model. Ultimately, we completed a simple and useful method for prediction of DDI. Currently, DDI prediction becomes more complex and difficult when examining issues such as dynamic changes in perpetrator level, inhibitory metabolites, etc...
October 7, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28962699/quantitative-prediction-of-fetal-plasma-concentration-of-fluvoxamine-during-dosage-tapering-to-the-mother
#13
Sayo Matsuoka, Satoko Hori, Hiroki Satoh, Takeshi Nagamatsu, Tomoyuki Fujii, Yasufumi Sawada
INTRODUCTION: Although selective serotonin reuptake inhibitors have been used during pregnancy for the treatment of depression and anxiety disorders, the fetal plasma concentration profiles of them remained unclear. Therefore, the aim of this study was to develop a pharmacokinetic model to estimate fetal plasma concentration profiles of fluvoxamine, and to clarify the differences with those of paroxetine. METHODS: Perfusion studies using human placentae obtained from full-term pregnant women were conducted to estimate transplacental pharmacokinetic parameters for fluvoxamine...
October 2017: Placenta
https://www.readbyqxmd.com/read/28953843/what-are-the-risks-associated-with-different-selective-serotonin-re-uptake-inhibitors-ssris-to-treat-depression-and-anxiety-in-pregnancy-an-evaluation-of-current-evidence
#14
Kate Womersley, Katherine Ripullone, Mark Agius
A literature review was conducted to elucidate the respective reproductive safety profiles of different SSRIs to inform the prescribing practices of doctors treating pregnant women with anxiety and depression. BACKGROUND: Women are most likely to be diagnosed with depression or anxiety between the ages of 25 and 44 years, which are also the years of childbearing potential (Burke et al., 1991). Therefore a substantial number of women face a decision about whether or not to take an antidepressant or anxiolytic during pregnancy...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28881483/meta-analysis-risk-of-hyperhidrosis-with-second-generation-antidepressants
#15
Chad Beyer, Kiley Cappetta, Jessica A Johnson, Michael H Bloch
BACKGROUND: Our goal was to quantify the risk of hyperhidrosis associated with commonly used antidepressant agents and examine the impact of medication class, pharmacodynamics, and dose on risk of hyperhidrosis. METHODS: We conducted a PubMed search to identify all double-blind, randomized, placebo-controlled trials examining the efficacy of second-generation antidepressant medications in the treatment of adults with a depressive disorder, anxiety disorders, or obsessive-compulsive disorder...
December 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28831260/an-observational-study-of-duloxetine-versus-ssri-monotherapy-in-japanese-patients-with-major-depressive-disorder-subgroup-analyses-of-treatment-effectiveness-for-pain-depressive-symptoms-and-quality-of-life
#16
Atsushi Kuga, Toshinaga Tsuji, Shinji Hayashi, Shinji Fujikoshi, Hirofumi Tokuoka, Aki Yoshikawa, Rodrigo Escobar, Kazuhide Tanaka, Takaharu Azekawa
OBJECTIVE: To examine how clinical and demographic patient baseline characteristics influence effectiveness of duloxetine versus selective serotonin reuptake inhibitor (SSRI) treatment, in real-world Japanese clinical settings of patients with major depressive disorder (MDD) and associated painful physical symptoms (PPS). METHODS: This was a multicenter, 12-week, prospective, observational study in patients with MDD (Quick Inventory of Depressive Symptomatology ≥16) and at least moderate PPS (Brief Pain Inventory-Short Form [BPI-SF] average pain ≥3)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28831259/an-observational-study-of-duloxetine-versus-ssri-monotherapy-for-the-treatment-of-painful-physical-symptoms-in-japanese-patients-with-major-depressive-disorder-primary-analysis
#17
Atsushi Kuga, Toshinaga Tsuji, Shinji Hayashi, Mako Matsubara, Shinji Fujikoshi, Hirofumi Tokuoka, Aki Yoshikawa, Rodrigo Escobar, Kazuhide Tanaka, Takaharu Azekawa
OBJECTIVE: The objective of this study was to assess the effectiveness of duloxetine monotherapy, in comparison with selective serotonin reuptake inhibitor (SSRI) monotherapy, in the treatment of painful physical symptoms (PPS) in Japanese patients with major depressive disorder (MDD) in real-world clinical settings. METHODS: This was a multicenter, 12-week prospective, observational study. This study enrolled MDD patients with at least moderate PPS, defined as a Brief Pain Inventory-Short Form (BPI-SF) average pain score (item 5) ≥3...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28815595/sigma-1-receptor-ligands-inhibit-catecholamine-secretion-from-adrenal-chromaffin-cells-due-to-block-of-nicotinic-acetylcholine-receptors
#18
Rebecca L Brindley, Mary Beth Bauer, Nolan D Hartley, Kyle J Horning, Kevin P M Currie
Adrenal chromaffin cells (ACCs) are the neuroendocrine arm of the sympathetic nervous system and key mediators of the physiological stress response. Acetylcholine (ACh) released from preganglionic splanchnic nerves activates nicotinic acetylcholine receptors (nAChRs) on chromaffin cells causing membrane depolarization, opening voltage-gated Ca(2+) channels (VGCC), and exocytosis of catecholamines and neuropeptides. The serotonin transporter is expressed in ACCs and interacts with 5-HT1A receptors to control secretion...
October 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28770276/a-comparative-study-of-qt-prolongation-with-serotonin-reuptake-inhibitors
#19
Ana Ojero-Senard, Justine Benevent, Emmanuelle Bondon-Guitton, Geneviève Durrieu, Leila Chebane, Melanie Araujo, Francois Montastruc, Jean-Louis Montastruc
BACKGROUND: QT interval prolongations were described with citalopram and escitalopram. However, the effects of the other serotonin reuptake inhibitors (SRIs) remained discussed. In order to identify a putative signal with other SRIs, the present study investigates the reports of QT interval prolongation with SRIs in two pharmacovigilance databases (PVDB). METHODS: Two kinds of investigations were performed: (1) a comparative study in VigiBase®, the WHO PVDB, where notifications of QT prolongation with six SRIs (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline) were selected...
October 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28763345/risk-of-hair-loss-with-different-antidepressants-a-comparative-retrospective-cohort-study
#20
Mahyar Etminan, Mohit Sodhi, Ric M Procyshyn, Michael Guo, Bruce C Carleton
The aim of this study was to quantify the risk of hair loss with different antidepressants. A retrospective cohort study design using a large health claims database in the USA from 2006 to 2014 was utilized. A cohort of new user and mutually exclusive users of fluoxetine, fluvoxamine, sertraline, citalopram, escitalopram, paroxetine, duloxetine, venlafaxine, desvenlafaxine, and bupropion were followed to the first diagnosis of alopecia. The cohort was comprised of 1 025 140 new users of fluoxetine, fluvoxamine, sertraline, citalopram, escitalopram, paroxetine, duloxetine, venlafaxine, desvenlafaxine, and bupropion, with sertraline the most commonly prescribed (N=190 227) and fluvoxamine (N=3010) the least prescribed...
July 31, 2017: International Clinical Psychopharmacology
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